Open-mkt buys · 90d
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0 trades · 0 insiders
Open-mkt sales · 90d
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0 trades · 0 insiders
Net · 90d
$0
Insiders on file
39
Daily buy vs sell · 90 days
No data yet.
Insiders
| Insider | Role | Trades | Bought | Sold | Last trade |
|---|---|---|---|---|---|
| MANNING MARTHA E | General Counsel | 10 | $10.2K | $0 | 2020-01-29 |
| Di Donato Brian | SVP, Chief Financial Officer | 3 | $0 | $0 | 2020-01-28 |
| Gibney Anthony S | EVP, Chief Business Officer | 4 | $0 | $0 | 2020-01-28 |
| Firuta Paul E | EVP, Chief Commercial Officer | 4 | $0 | $0 | 2020-01-28 |
| Zelenkofske Steven | EVP, Chief Medical Officer | 4 | $0 | $0 | 2020-01-28 |
| Verwiel Frank | Director | 9 | $0 | $0 | 2020-01-28 |
| Truitt Joseph | SVP, Chief Commercial Officer | 38 | $14.2K | $1.62M | 2020-01-28 |
| SUSQUEHANNA SECURITIES, LLC | 10% Owner | 2 | $0 | $0 | 2020-01-28 |
| Graves Kurt | Director | 15 | $0 | $0 | 2020-01-28 |
| Scheer David | Director | 21 | $0 | $66.2K | 2020-01-28 |
| VAN NOSTRAND ROBERT L | Director | 19 | $0 | $0 | 2020-01-28 |
| FISHERMAN JASON S | Director | 28 | $268.3K | $0 | 2020-01-28 |
| VITULLO NICOLE | Director, 10% Owner | 46 | $0 | $5.96M | 2020-01-28 |
| KISHBAUCH MICHAEL D | Director | 40 | $0 | $11.06M | 2020-01-28 |
| Lantz Keri | See Remarks | 1 | $0 | $0 | 2019-01-23 |
| Fenton Mary Kay | SVP and CFO | 18 | $10.3K | $816.8K | 2018-02-09 |
| Deshpande Milind | President of R&D and CSO | 31 | $10.1K | $3.82M | 2018-02-09 |
| FRASHIER GARY E | Director | 33 | $0 | $1.10M | 2018-02-09 |
| Johnson & Johnson Innovation - JJDC, Inc. | 10% Owner | 1 | $0 | $50.51M | 2017-11-20 |
| Barrish Joel C | Chief Scientific Officer | 4 | $10.1K | $0 | 2017-01-17 |
| Apelian David | EVP and Chief Medical Officer | 9 | $0 | $105.0K | 2017-01-17 |
| Liotta Dennis | Director | 8 | $344.3K | $0 | 2014-12-02 |
| Shah Gautam | SVP and Chief Compliance Ofc. | 39 | $0 | $1.44M | 2014-12-02 |
| RA Capital Healthcare Fund LP | Other | 54 | $4.75M | $55.39M | 2014-09-30 |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | 55 | $28.62M | $74.32M | 2014-09-26 |
| Kolchinsky Peter | 10% Owner | 48 | $10.66M | $34.75B | 2014-09-23 |
| QVT Associates GP LLC | 10% Owner | 36 | $16.65M | $27.47M | 2014-06-16 |
| QVT Fund V LP | 10% Owner | 7 | $5.72M | $0 | 2013-08-09 |
| Domain Partners VIII, L.P. | 10% Owner | 2 | $0 | $0 | 2013-01-18 |
| Halak Brian K | 10% Owner | 4 | $0 | $0 | 2013-01-18 |
| SCHOEMAKER KATHLEEN K | 10% Owner | 4 | $0 | $0 | 2013-01-18 |
| DOVEY BRIAN H | 10% Owner | 4 | $0 | $0 | 2013-01-18 |
| BLAIR JAMES C | 10% Owner | 4 | $0 | $0 | 2013-01-18 |
| TREU JESSE I | 10% Owner | 4 | $0 | $0 | 2013-01-18 |
| WRIGHT DAVID P | Director | 4 | $0 | $64.3K | 2012-12-18 |
| Simon Nicholas | Director | 2 | $0 | $0 | 2012-06-04 |
| GALAKATOS NICHOLAS | 10% Owner | 1 | $0 | $0 | 2012-06-04 |
| HENNER DENNIS | 10% Owner | 6 | $0 | $9.86M | 2012-05-31 |
| Olek Elizabeth A | SVP and CMO | 3 | $0 | $125.4K | 2012-01-10 |
Trade history
| Insider | Role | Code | Trade | Filed | Shares | Price | Value | Owned after | |
|---|---|---|---|---|---|---|---|---|---|
| MANNING MARTHA E | General Counsel | D To issuer deriv | 2020-01-29 | 2020-01-29 | 110,000 | — | $0 | 0 | SEC↗ |
| MANNING MARTHA E | General Counsel | D To issuer deriv | 2020-01-29 | 2020-01-29 | 135,000 | — | $0 | 0 | SEC↗ |
| Di Donato Brian | SVP, Chief Financial Officer | D To issuer deriv | 2020-01-28 | 2020-01-29 | 500,000 | — | $0 | 0 | SEC↗ |
| Di Donato Brian | SVP, Chief Financial Officer | D To issuer deriv | 2020-01-28 | 2020-01-29 | 200,000 | — | $0 | 0 | SEC↗ |
| Firuta Paul E | EVP, Chief Commercial Office | D To issuer deriv | 2020-01-28 | 2020-01-29 | 200,000 | — | $0 | 0 | SEC↗ |
| Firuta Paul E | EVP, Chief Commercial Office | D To issuer deriv | 2020-01-28 | 2020-01-29 | 400,000 | — | $0 | 0 | SEC↗ |
| FISHERMAN JASON S | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 25,000 | — | $0 | 0 | SEC↗ |
| FISHERMAN JASON S | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 30,000 | — | $0 | 0 | SEC↗ |
| FISHERMAN JASON S | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 42,000 | — | $0 | 0 | SEC↗ |
| FISHERMAN JASON S | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 20,000 | — | $0 | 0 | SEC↗ |
| FISHERMAN JASON S | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 30,000 | — | $0 | 0 | SEC↗ |
| FISHERMAN JASON S | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 30,000 | — | $0 | 0 | SEC↗ |
| FISHERMAN JASON S | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 50,000 | — | $0 | 0 | SEC↗ |
| Gibney Anthony S | EVP, Chief Business Officer | D To issuer deriv | 2020-01-28 | 2020-01-29 | 200,000 | — | $0 | 0 | SEC↗ |
| Gibney Anthony S | EVP, Chief Business Officer | D To issuer deriv | 2020-01-28 | 2020-01-29 | 500,000 | — | $0 | 0 | SEC↗ |
| Graves Kurt | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 25,000 | — | $0 | 0 | SEC↗ |
| Graves Kurt | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 30,000 | — | $0 | 0 | SEC↗ |
| Graves Kurt | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 135,000 | — | $0 | 0 | SEC↗ |
| Graves Kurt | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 30,000 | — | $0 | 0 | SEC↗ |
| Graves Kurt | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 42,000 | — | $0 | 0 | SEC↗ |
| Graves Kurt | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 30,000 | — | $0 | 0 | SEC↗ |
| KISHBAUCH MICHAEL D | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 30,000 | — | $0 | 0 | SEC↗ |
| KISHBAUCH MICHAEL D | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 30,000 | — | $0 | 0 | SEC↗ |
| KISHBAUCH MICHAEL D | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 25,000 | — | $0 | 0 | SEC↗ |
| KISHBAUCH MICHAEL D | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 30,000 | — | $0 | 0 | SEC↗ |
| KISHBAUCH MICHAEL D | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 6,250 | — | $0 | 0 | SEC↗ |
| KISHBAUCH MICHAEL D | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 42,000 | — | $0 | 0 | SEC↗ |
| MANNING MARTHA E | General Counsel | D To issuer deriv | 2020-01-28 | 2020-01-29 | 150,000 | — | $0 | 0 | SEC↗ |
| MANNING MARTHA E | General Counsel | D To issuer deriv | 2020-01-28 | 2020-01-29 | 215,000 | — | $0 | 0 | SEC↗ |
| Scheer David | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 50,000 | — | $0 | 0 | SEC↗ |
| Scheer David | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 30,000 | — | $0 | 0 | SEC↗ |
| Scheer David | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 25,000 | — | $0 | 0 | SEC↗ |
| Scheer David | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 30,000 | — | $0 | 0 | SEC↗ |
| Scheer David | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 42,000 | — | $0 | 0 | SEC↗ |
| Scheer David | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 20,000 | — | $0 | 0 | SEC↗ |
| Scheer David | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 30,000 | — | $0 | 0 | SEC↗ |
| Truitt Joseph | Chief Executive Officer | D To issuer deriv | 2020-01-28 | 2020-01-29 | 632,000 | — | $0 | 0 | SEC↗ |
| Truitt Joseph | Chief Executive Officer | D To issuer deriv | 2020-01-28 | 2020-01-29 | 185,000 | — | $0 | 0 | SEC↗ |
| Truitt Joseph | Chief Executive Officer | D To issuer deriv | 2020-01-28 | 2020-01-29 | 100,000 | — | $0 | 0 | SEC↗ |
| Truitt Joseph | Chief Executive Officer | D To issuer deriv | 2020-01-28 | 2020-01-29 | 142,000 | — | $0 | 0 | SEC↗ |
| Truitt Joseph | Chief Executive Officer | D To issuer deriv | 2020-01-28 | 2020-01-29 | 200,000 | — | $0 | 0 | SEC↗ |
| Truitt Joseph | Chief Executive Officer | D To issuer deriv | 2020-01-28 | 2020-01-29 | 419,000 | — | $0 | 0 | SEC↗ |
| Truitt Joseph | Chief Executive Officer | D To issuer deriv | 2020-01-28 | 2020-01-29 | 1,097,000 | — | $0 | 0 | SEC↗ |
| Truitt Joseph | Chief Executive Officer | D To issuer deriv | 2020-01-28 | 2020-01-29 | 30,000 | — | $0 | 0 | SEC↗ |
| Truitt Joseph | Chief Executive Officer | D To issuer deriv | 2020-01-28 | 2020-01-29 | 87,766 | — | $0 | 0 | SEC↗ |
| VAN NOSTRAND ROBERT L | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 30,000 | — | $0 | 0 | SEC↗ |
| VAN NOSTRAND ROBERT L | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 30,000 | — | $0 | 0 | SEC↗ |
| VAN NOSTRAND ROBERT L | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 20,000 | — | $0 | 0 | SEC↗ |
| VAN NOSTRAND ROBERT L | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 42,000 | — | $0 | 0 | SEC↗ |
| VAN NOSTRAND ROBERT L | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 30,000 | — | $0 | 0 | SEC↗ |
| VAN NOSTRAND ROBERT L | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 25,000 | — | $0 | 0 | SEC↗ |
| VAN NOSTRAND ROBERT L | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 50,000 | — | $0 | 0 | SEC↗ |
| Verwiel Frank | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 42,000 | — | $0 | 0 | SEC↗ |
| Verwiel Frank | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 30,000 | — | $0 | 0 | SEC↗ |
| Verwiel Frank | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 30,000 | — | $0 | 0 | SEC↗ |
| Verwiel Frank | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 30,000 | — | $0 | 0 | SEC↗ |
| Zelenkofske Steven | EVP, Chief Medical Officer | D To issuer deriv | 2020-01-28 | 2020-01-29 | 500,000 | — | $0 | 0 | SEC↗ |
| Zelenkofske Steven | EVP, Chief Medical Officer | D To issuer deriv | 2020-01-28 | 2020-01-29 | 200,000 | — | $0 | 0 | SEC↗ |
| VITULLO NICOLE | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 50,000 | — | $0 | 0 | SEC↗ |
| VITULLO NICOLE | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 20,000 | — | $0 | 0 | SEC↗ |
| VITULLO NICOLE | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 20,000 | — | $0 | 0 | SEC↗ |
| VITULLO NICOLE | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 25,000 | — | $0 | 0 | SEC↗ |
| VITULLO NICOLE | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 25,000 | — | $0 | 0 | SEC↗ |
| VITULLO NICOLE | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 30,000 | — | $0 | 0 | SEC↗ |
| VITULLO NICOLE | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 30,000 | — | $0 | 0 | SEC↗ |
| VITULLO NICOLE | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 42,000 | — | $0 | 0 | SEC↗ |
| VITULLO NICOLE | Director | D To issuer deriv | 2020-01-28 | 2020-01-29 | 30,000 | — | $0 | 0 | SEC↗ |
| FISHERMAN JASON S | Director | D To issuer | 2020-01-28 | 2020-01-29 | 90,000 | $6.30 | $567.0K | 0 | SEC↗ |
| FISHERMAN JASON S | Director | D To issuer | 2020-01-28 | 2020-01-29 | 1,500 | $6.30 | $9.4K | 0 | SEC↗ |
| Graves Kurt | Director | D To issuer | 2020-01-28 | 2020-01-29 | 22,709 | $6.30 | $143.1K | 0 | SEC↗ |
| MANNING MARTHA E | General Counsel | D To issuer | 2020-01-28 | 2020-01-29 | 2,500 | $6.30 | $15.8K | 0 | SEC↗ |
| Scheer David | Director | D To issuer | 2020-01-28 | 2020-01-29 | 63,249 | $6.30 | $398.5K | 0 | SEC↗ |
| Scheer David | Director | D To issuer | 2020-01-28 | 2020-01-29 | 29,515 | $6.30 | $185.9K | 0 | SEC↗ |
| Truitt Joseph | Chief Executive Officer | D To issuer | 2020-01-28 | 2020-01-29 | 3,500 | $6.30 | $22.1K | 0 | SEC↗ |
| VAN NOSTRAND ROBERT L | Director | D To issuer | 2020-01-28 | 2020-01-29 | 40,000 | $6.30 | $252.0K | 0 | SEC↗ |
| VITULLO NICOLE | Director | D To issuer | 2020-01-28 | 2020-01-29 | 25,159 | $6.30 | $158.5K | 0 | SEC↗ |
| VITULLO NICOLE | Director | D To issuer | 2020-01-28 | 2020-01-29 | 36,431 | $6.30 | $229.5K | 0 | SEC↗ |
| VITULLO NICOLE | Director | D To issuer | 2020-01-28 | 2020-01-29 | 3,393,382 | $6.30 | $21.38M | 0 | SEC↗ |
| SUSQUEHANNA SECURITIES, LLC | 10% Owner | J Other | 2020-01-28 | 2020-01-30 | 14,115,498 | $6.30 | $88.93M | 0 | SEC↗ |
| SUSQUEHANNA SECURITIES, LLC | 10% Owner | J Other | 2020-01-28 | 2020-01-30 | 10,917 | $6.30 | $68.8K | 0 | SEC↗ |
| VAN NOSTRAND ROBERT L | Director | M Exercise deriv | 2019-12-18 | 2019-12-19 | 20,000 | — | $0 | 0 | SEC↗ |
| VAN NOSTRAND ROBERT L | Director | M Exercise | 2019-12-18 | 2019-12-19 | 20,000 | $3.28 | $65.6K | 40,000 | SEC↗ |
| FISHERMAN JASON S | Director | M Exercise deriv | 2019-11-14 | 2019-11-14 | 20,000 | — | $0 | 0 | SEC↗ |
| FISHERMAN JASON S | Director | M Exercise | 2019-11-14 | 2019-11-14 | 20,000 | $3.28 | $65.6K | 90,000 | SEC↗ |
| Scheer David | Director | M Exercise deriv | 2019-11-13 | 2019-11-14 | 20,000 | — | $0 | 0 | SEC↗ |
| Scheer David | Director | M Exercise | 2019-11-13 | 2019-11-14 | 20,000 | $3.28 | $65.6K | 40,000 | SEC↗ |
| Scheer David | Director | S Sale | 2019-11-13 | 2019-11-14 | 10,485 | $6.31 | $66.2K | 29,515 | SEC↗ |
| Truitt Joseph | Chief Executive Officer | M Exercise deriv | 2019-10-16 | 2019-10-18 | 100,234 | — | $0 | 87,766 | SEC↗ |
| Truitt Joseph | Chief Executive Officer | M Exercise deriv | 2019-10-16 | 2019-10-18 | 33,250 | — | $0 | 0 | SEC↗ |
| Truitt Joseph | Chief Executive Officer | S Sale | 2019-10-16 | 2019-10-18 | 100,234 | $6.37 | $638.5K | 36,750 | SEC↗ |
| Truitt Joseph | Chief Executive Officer | M Exercise | 2019-10-16 | 2019-10-18 | 33,250 | $3.28 | $109.1K | 136,984 | SEC↗ |
| Truitt Joseph | Chief Executive Officer | M Exercise | 2019-10-16 | 2019-10-18 | 100,234 | $3.10 | $310.7K | 103,734 | SEC↗ |
| Truitt Joseph | Chief Executive Officer | S Sale | 2019-10-16 | 2019-10-18 | 33,250 | $6.37 | $211.8K | 3,500 | SEC↗ |
| Di Donato Brian | Chief Financial Officer | A Award deriv | 2019-02-11 | 2019-02-11 | 500,000 | — | $0 | 500,000 | SEC↗ |
| VITULLO NICOLE | Director | A Award deriv | 2019-01-23 | 2019-01-25 | 42,000 | — | $0 | 42,000 | SEC↗ |
| Firuta Paul E | Chief Operating Officer | A Award deriv | 2019-01-23 | 2019-01-25 | 200,000 | — | $0 | 200,000 | SEC↗ |
| Gibney Anthony S | Chief Business Officer | A Award deriv | 2019-01-23 | 2019-01-25 | 200,000 | — | $0 | 200,000 | SEC↗ |
| Lantz Keri | See Remarks | A Award deriv | 2019-01-23 | 2019-01-25 | 100,000 | — | $0 | 100,000 | SEC↗ |
| MANNING MARTHA E | General Counsel | A Award deriv | 2019-01-23 | 2019-01-25 | 150,000 | — | $0 | 150,000 | SEC↗ |
| Truitt Joseph | Chief Executive Officer | A Award deriv | 2019-01-23 | 2019-01-25 | 1,097,000 | — | $0 | 1,097,000 | SEC↗ |
| Zelenkofske Steven | Chief Medical Officer | A Award deriv | 2019-01-23 | 2019-01-25 | 200,000 | — | $0 | 200,000 | SEC↗ |
| FISHERMAN JASON S | Director | A Award deriv | 2019-01-23 | 2019-01-25 | 42,000 | — | $0 | 42,000 | SEC↗ |
| Graves Kurt | Director | A Award deriv | 2019-01-23 | 2019-01-25 | 42,000 | — | $0 | 42,000 | SEC↗ |
| KISHBAUCH MICHAEL D | Director | A Award deriv | 2019-01-23 | 2019-01-25 | 42,000 | — | $0 | 42,000 | SEC↗ |
| Scheer David | Director | A Award deriv | 2019-01-23 | 2019-01-25 | 42,000 | — | $0 | 42,000 | SEC↗ |
| VAN NOSTRAND ROBERT L | Director | A Award deriv | 2019-01-23 | 2019-01-25 | 42,000 | — | $0 | 42,000 | SEC↗ |
| Verwiel Frank | Director | A Award deriv | 2019-01-23 | 2019-01-25 | 42,000 | — | $0 | 42,000 | SEC↗ |
| VAN NOSTRAND ROBERT L | Director | M Exercise deriv | 2018-12-14 | 2018-12-18 | 20,000 | — | $0 | 0 | SEC↗ |
| Scheer David | Director | M Exercise deriv | 2018-12-14 | 2018-12-18 | 20,000 | — | $0 | 0 | SEC↗ |
| VAN NOSTRAND ROBERT L | Director | M Exercise | 2018-12-14 | 2018-12-18 | 20,000 | $1.05 | $21.0K | 20,000 | SEC↗ |
| Scheer David | Director | M Exercise | 2018-12-14 | 2018-12-18 | 20,000 | $1.05 | $21.0K | 20,000 | SEC↗ |
| Firuta Paul E | Chief Operating Officer | A Award deriv | 2018-09-11 | 2018-09-12 | 400,000 | — | $0 | 400,000 | SEC↗ |
| Zelenkofske Steven | Chief Medical Officer | A Award deriv | 2018-08-20 | 2018-08-21 | 500,000 | — | $0 | 500,000 | SEC↗ |
| Gibney Anthony S | Chief Business Officer | A Award deriv | 2018-08-15 | 2018-08-16 | 500,000 | — | $0 | 500,000 | SEC↗ |
| FISHERMAN JASON S | Director | M Exercise deriv | 2018-06-06 | 2018-06-08 | 20,000 | — | $0 | 0 | SEC↗ |
| FISHERMAN JASON S | Director | M Exercise | 2018-06-06 | 2018-06-08 | 20,000 | $1.05 | $21.0K | 70,000 | SEC↗ |
| VITULLO NICOLE | Director | J Other | 2018-05-31 | 2018-06-04 | 25,000 | — | $0 | 0 | SEC↗ |
| VITULLO NICOLE | Director | J Other | 2018-05-31 | 2018-06-04 | 5,000 | — | $0 | 36,431 | SEC↗ |
| Truitt Joseph | Chief Executive Officer | A Award deriv | 2018-05-01 | 2018-05-03 | 632,000 | — | $0 | 632,000 | SEC↗ |
| VITULLO NICOLE | Director | A Award deriv | 2018-02-09 | 2018-02-13 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Verwiel Frank | Director | A Award deriv | 2018-02-09 | 2018-02-13 | 30,000 | — | $0 | 30,000 | SEC↗ |
| VAN NOSTRAND ROBERT L | Director | A Award deriv | 2018-02-09 | 2018-02-13 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Scheer David | Director | A Award deriv | 2018-02-09 | 2018-02-13 | 30,000 | — | $0 | 30,000 | SEC↗ |
| KISHBAUCH MICHAEL D | Director | A Award deriv | 2018-02-09 | 2018-02-13 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Graves Kurt | Director | A Award deriv | 2018-02-09 | 2018-02-13 | 30,000 | — | $0 | 30,000 | SEC↗ |
| FRASHIER GARY E | Director | A Award deriv | 2018-02-09 | 2018-02-13 | 30,000 | — | $0 | 30,000 | SEC↗ |
| FISHERMAN JASON S | Director | A Award deriv | 2018-02-09 | 2018-02-13 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Truitt Joseph | Chief Commercial Officer | A Award deriv | 2018-02-09 | 2018-02-13 | 419,000 | — | $0 | 419,000 | SEC↗ |
| MANNING MARTHA E | General Counsel | A Award deriv | 2018-02-09 | 2018-02-13 | 215,000 | — | $0 | 215,000 | SEC↗ |
| Fenton Mary Kay | Chief Financial Officer | A Award deriv | 2018-02-09 | 2018-02-13 | 250,000 | — | $0 | 250,000 | SEC↗ |
| Deshpande Milind | Chief Executive Officer | A Award deriv | 2018-02-09 | 2018-02-13 | 640,000 | — | $0 | 640,000 | SEC↗ |
| Johnson & Johnson Innovation - | 10% Owner | S Sale | 2017-11-20 | 2017-11-22 | 18,367,346 | $2.75 | $50.51M | 0 | SEC↗ |
| VITULLO NICOLE | Director | M Exercise deriv | 2017-08-10 | 2017-08-14 | 20,706 | — | $0 | 0 | SEC↗ |
| VITULLO NICOLE | Director | M Exercise deriv | 2017-08-10 | 2017-08-14 | 2,790,539 | — | $0 | 0 | SEC↗ |
| VITULLO NICOLE | Director | M Exercise | 2017-08-10 | 2017-08-14 | 20,706 | $3.11 | $64.4K | 37,885 | SEC↗ |
| VITULLO NICOLE | Director | F Tax w/h | 2017-08-10 | 2017-08-14 | 1,714,954 | $5.06 | $8.68M | 3,393,382 | SEC↗ |
| VITULLO NICOLE | Director | M Exercise | 2017-08-10 | 2017-08-14 | 2,790,539 | $3.11 | $8.68M | 5,108,336 | SEC↗ |
| VITULLO NICOLE | Director | F Tax w/h | 2017-08-10 | 2017-08-14 | 12,726 | $5.06 | $64.4K | 25,159 | SEC↗ |
| FISHERMAN JASON S | Director | W Will | 2017-06-28 | 2017-06-30 | 1,500 | — | $0 | 1,500 | SEC↗ |
| FISHERMAN JASON S | Director | A Award deriv | 2017-01-19 | 2017-01-19 | 30,000 | — | $0 | 30,000 | SEC↗ |
| FRASHIER GARY E | Director | A Award deriv | 2017-01-19 | 2017-01-19 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Graves Kurt | Director | A Award deriv | 2017-01-19 | 2017-01-19 | 30,000 | — | $0 | 30,000 | SEC↗ |
| KISHBAUCH MICHAEL D | Director | A Award deriv | 2017-01-19 | 2017-01-19 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Scheer David | Director | A Award deriv | 2017-01-19 | 2017-01-19 | 30,000 | — | $0 | 30,000 | SEC↗ |
| VAN NOSTRAND ROBERT L | Director | A Award deriv | 2017-01-19 | 2017-01-19 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Verwiel Frank | Director | A Award deriv | 2017-01-19 | 2017-01-19 | 30,000 | — | $0 | 30,000 | SEC↗ |
| VITULLO NICOLE | Director | A Award deriv | 2017-01-19 | 2017-01-19 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Apelian David | Chief Medical Officer | A Award deriv | 2017-01-17 | 2017-01-19 | 185,000 | — | $0 | 185,000 | SEC↗ |
| Deshpande Milind | Chief Executive Officer | A Award deriv | 2017-01-17 | 2017-01-19 | 458,000 | — | $0 | 458,000 | SEC↗ |
| Barrish Joel C | Chief Scientific Officer | A Award deriv | 2017-01-17 | 2017-01-19 | 185,000 | — | $0 | 185,000 | SEC↗ |
| Fenton Mary Kay | Chief Financial Officer | A Award deriv | 2017-01-17 | 2017-01-19 | 165,000 | — | $0 | 165,000 | SEC↗ |
| MANNING MARTHA E | EVP, General Counsel | A Award deriv | 2017-01-17 | 2017-01-19 | 135,000 | — | $0 | 135,000 | SEC↗ |
| Truitt Joseph | Chief Commercial Officer | A Award deriv | 2017-01-17 | 2017-01-19 | 185,000 | — | $0 | 185,000 | SEC↗ |
| FISHERMAN JASON S | Director | P Buy | 2016-12-22 | 2016-12-23 | 10,000 | $3.96 | $39.6K | 50,000 | SEC↗ |
| Fenton Mary Kay | Chief Financial Officer | P Buy | 2016-12-05 | 2016-12-05 | 2,500 | $4.11 | $10.3K | 2,500 | SEC↗ |
| Barrish Joel C | Chief Scientific Officer | P Buy | 2016-12-02 | 2016-12-05 | 2,500 | $4.06 | $10.1K | 2,500 | SEC↗ |
| Deshpande Milind | Chief Executive Officer | P Buy | 2016-12-02 | 2016-12-05 | 2,500 | $4.06 | $10.1K | 2,500 | SEC↗ |
| MANNING MARTHA E | EVP, General Counsel | P Buy | 2016-12-02 | 2016-12-05 | 2,500 | $4.09 | $10.2K | 2,500 | SEC↗ |
| Truitt Joseph | Chief Commercial Officer | P Buy | 2016-12-02 | 2016-12-05 | 3,500 | $4.06 | $14.2K | 3,500 | SEC↗ |
| MANNING MARTHA E | EVP, General Counsel | A Award deriv | 2016-02-01 | 2016-02-03 | 110,000 | — | $0 | 110,000 | SEC↗ |
| VITULLO NICOLE | Director | A Award deriv | 2016-01-25 | 2016-01-26 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Verwiel Frank | Director | A Award deriv | 2016-01-25 | 2016-01-27 | 30,000 | — | $0 | 30,000 | SEC↗ |
| VAN NOSTRAND ROBERT L | Director | A Award deriv | 2016-01-25 | 2016-01-27 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Scheer David | Director | A Award deriv | 2016-01-25 | 2016-01-27 | 30,000 | — | $0 | 30,000 | SEC↗ |
| KISHBAUCH MICHAEL D | Director | A Award deriv | 2016-01-25 | 2016-01-27 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Graves Kurt | Director | A Award deriv | 2016-01-25 | 2016-01-27 | 30,000 | — | $0 | 30,000 | SEC↗ |
| FRASHIER GARY E | Director | A Award deriv | 2016-01-25 | 2016-01-27 | 30,000 | — | $0 | 30,000 | SEC↗ |
| FISHERMAN JASON S | Director | A Award deriv | 2016-01-25 | 2016-01-27 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Deshpande Milind | Chief Executive Officer | A Award deriv | 2016-01-20 | 2016-01-22 | 400,000 | — | $0 | 400,000 | SEC↗ |
| Fenton Mary Kay | Chief Financial Officer | A Award deriv | 2016-01-20 | 2016-01-22 | 118,000 | — | $0 | 118,000 | SEC↗ |
| Apelian David | Chief Medical Officer | A Award deriv | 2016-01-20 | 2016-01-22 | 118,000 | — | $0 | 118,000 | SEC↗ |
| Barrish Joel C | Chief Scientific Officer | A Award deriv | 2016-01-20 | 2016-01-22 | 20,000 | — | $0 | 20,000 | SEC↗ |
| Truitt Joseph | Chief Commercial Officer | A Award deriv | 2016-01-20 | 2016-01-22 | 142,000 | — | $0 | 142,000 | SEC↗ |
| Barrish Joel C | Chief Scientific Officer | A Award deriv | 2016-01-04 | 2016-01-05 | 250,000 | — | $0 | 250,000 | SEC↗ |
| Apelian David | Chief Medical Officer | M Exercise deriv | 2015-12-30 | 2015-12-30 | 10,000 | — | $0 | 290,000 | SEC↗ |
| Apelian David | Chief Medical Officer | M Exercise | 2015-12-30 | 2015-12-30 | 10,000 | $3.02 | $30.2K | 10,000 | SEC↗ |
| Apelian David | Chief Medical Officer | S Sale | 2015-12-30 | 2015-12-30 | 10,000 | $10.50 | $105.0K | 0 | SEC↗ |
| Fenton Mary Kay | Chief Financial Officer | M Exercise deriv | 2015-12-28 | 2015-12-30 | 43,500 | — | $0 | 0 | SEC↗ |
| Fenton Mary Kay | Chief Financial Officer | S Sale | 2015-12-28 | 2015-12-30 | 43,500 | $10.08 | $438.5K | 0 | SEC↗ |
| Fenton Mary Kay | Chief Financial Officer | M Exercise | 2015-12-28 | 2015-12-30 | 43,500 | $1.05 | $45.7K | 43,500 | SEC↗ |
| Verwiel Frank | Director | A Award deriv | 2015-12-14 | 2015-12-16 | 30,000 | — | $0 | 30,000 | SEC↗ |
| VITULLO NICOLE | Director | S Sale | 2015-11-11 | 2015-11-12 | 49,630 | $10.31 | $511.7K | 2,317,797 | SEC↗ |
| VITULLO NICOLE | Director | S Sale | 2015-11-11 | 2015-11-12 | 370 | $10.31 | $3.8K | 17,179 | SEC↗ |
| VITULLO NICOLE | Director | S Sale | 2015-11-10 | 2015-11-12 | 1,325 | $10.43 | $13.8K | 17,549 | SEC↗ |
| VITULLO NICOLE | Director | S Sale | 2015-11-10 | 2015-11-12 | 177,749 | $10.43 | $1.85M | 2,367,427 | SEC↗ |
| VITULLO NICOLE | Director | S Sale | 2015-11-09 | 2015-11-12 | 2,375 | $10.01 | $23.8K | 18,874 | SEC↗ |
| VITULLO NICOLE | Director | S Sale | 2015-11-09 | 2015-11-12 | 318,551 | $10.01 | $3.19M | 2,545,176 | SEC↗ |
| VITULLO NICOLE | Director | S Sale | 2015-09-25 | 2015-09-29 | 69 | $8.22 | $567 | 21,249 | SEC↗ |
| VITULLO NICOLE | Director | S Sale | 2015-09-25 | 2015-09-29 | 9,241 | $8.22 | $76.0K | 2,863,727 | SEC↗ |
| VITULLO NICOLE | Director | J Other | 2015-08-18 | 2015-08-18 | 483,521 | — | $0 | 0 | SEC↗ |
| VITULLO NICOLE | Director | J Other | 2015-08-18 | 2015-08-18 | 31,431 | — | $0 | 31,431 | SEC↗ |
| VITULLO NICOLE | Director | S Sale | 2015-08-14 | 2015-08-18 | 37,843 | $7.51 | $284.2K | 21,318 | SEC↗ |
| VITULLO NICOLE | Director | J Other | 2015-05-21 | 2015-05-22 | 1,700,000 | — | $0 | 2,872,968 | SEC↗ |
| VITULLO NICOLE | Director | J Other | 2015-05-21 | 2015-05-22 | 222,630 | — | $0 | 483,521 | SEC↗ |
| Fenton Mary Kay | EVP and CFO | M Exercise deriv | 2015-01-23 | 2015-01-23 | 13,125 | — | $0 | 0 | SEC↗ |
| Fenton Mary Kay | EVP and CFO | S Sale | 2015-01-23 | 2015-01-23 | 13,125 | $16.00 | $210.0K | 0 | SEC↗ |
| Fenton Mary Kay | EVP and CFO | M Exercise | 2015-01-23 | 2015-01-23 | 13,125 | $4.00 | $52.5K | 13,125 | SEC↗ |
| Deshpande Milind | President and CEO | M Exercise deriv | 2015-01-21 | 2015-01-23 | 100,000 | — | $0 | 300,000 | SEC↗ |
| Deshpande Milind | President and CEO | S Sale | 2015-01-21 | 2015-01-23 | 100,000 | $15.00 | $1.50M | 0 | SEC↗ |
| Deshpande Milind | President and CEO | M Exercise | 2015-01-21 | 2015-01-23 | 100,000 | $3.02 | $302.0K | 100,000 | SEC↗ |
| VITULLO NICOLE | Director | A Award deriv | 2014-12-02 | 2014-12-04 | 25,000 | — | $0 | 25,000 | SEC↗ |
| Deshpande Milind | President and CEO | A Award deriv | 2014-12-02 | 2014-12-04 | 345,000 | — | $0 | 345,000 | SEC↗ |
| Fenton Mary Kay | EVP and CFO | A Award deriv | 2014-12-02 | 2014-12-04 | 110,000 | — | $0 | 110,000 | SEC↗ |
| Apelian David | EVP and Chief Medical Office | A Award deriv | 2014-12-02 | 2014-12-04 | 175,000 | — | $0 | 175,000 | SEC↗ |
| Shah Gautam | EVP and Chief Compliance Ofc | A Award deriv | 2014-12-02 | 2014-12-04 | 95,000 | — | $0 | 95,000 | SEC↗ |
| Truitt Joseph | EVP, Chief Commercial Office | A Award deriv | 2014-12-02 | 2014-12-04 | 110,000 | — | $0 | 110,000 | SEC↗ |
| FISHERMAN JASON S | Director | A Award deriv | 2014-12-02 | 2014-12-04 | 25,000 | — | $0 | 25,000 | SEC↗ |
| FRASHIER GARY E | Director | A Award deriv | 2014-12-02 | 2014-12-04 | 25,000 | — | $0 | 25,000 | SEC↗ |
| Graves Kurt | Director | A Award deriv | 2014-12-02 | 2014-12-04 | 25,000 | — | $0 | 25,000 | SEC↗ |
| KISHBAUCH MICHAEL D | Director | A Award deriv | 2014-12-02 | 2014-12-04 | 25,000 | — | $0 | 25,000 | SEC↗ |
| Liotta Dennis | Director | A Award deriv | 2014-12-02 | 2014-12-04 | 25,000 | — | $0 | 25,000 | SEC↗ |
| Scheer David | Director | A Award deriv | 2014-12-02 | 2014-12-04 | 25,000 | — | $0 | 25,000 | SEC↗ |
| VAN NOSTRAND ROBERT L | Director | A Award deriv | 2014-12-02 | 2014-12-04 | 25,000 | — | $0 | 25,000 | SEC↗ |
| Apelian David | EVP and CMO | A Award deriv | 2014-12-02 | 2014-12-05 | 175,000 | — | $0 | 175,000 | SEC↗ |
| FISHERMAN JASON S | Director | A Award deriv | 2014-12-02 | 2014-12-05 | 25,000 | — | $0 | 25,000 | SEC↗ |
| RA Capital Healthcare Fund LP | Other | S Sale | 2014-09-30 | 2014-10-01 | 411,000 | $10.11 | $4.16M | 7,400,000 | SEC↗ |
| RA Capital Healthcare Fund LP | Other | S Sale | 2014-09-30 | 2014-10-01 | 700,000 | $10.02 | $7.01M | 6,700,000 | SEC↗ |
| RA Capital Healthcare Fund LP | Other | S Sale | 2014-09-29 | 2014-10-01 | 221,014 | $10.96 | $2.42M | 7,811,000 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-09-26 | 2014-09-26 | 250,000 | $11.10 | $2.77M | 8,032,014 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-09-26 | 2014-09-26 | 120,000 | $10.96 | $1.32M | 8,282,014 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-09-26 | 2014-09-26 | 300,000 | $11.12 | $3.34M | 8,402,014 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-09-25 | 2014-09-26 | 250,000 | $11.06 | $2.77M | 8,702,014 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-09-25 | 2014-09-26 | 131,800 | $11.06 | $1.46M | 8,952,014 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-09-25 | 2014-09-26 | 116,186 | $11.01 | $1.28M | 9,083,814 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-09-24 | 2014-09-26 | 500,000 | $11.28 | $5.64M | 9,200,000 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-09-24 | 2014-09-26 | 210,109 | $11.29 | $2.37M | 9,700,000 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-09-24 | 2014-09-26 | 319,100 | $11.25 | $3.59M | 9,910,109 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-09-24 | 2014-09-26 | 175,720 | $11.24 | $1.98M | 10,229,209 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-23 | 2014-09-23 | 655,239 | $11.11 | $7.28M | 10,722,429 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-23 | 2014-09-23 | 11,783 | $11.10 | $130.8K | 11,377,668 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-23 | 2014-09-23 | 317,500 | $11.02 | $3.50M | 10,404,929 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-22 | 2014-09-23 | 60,549 | $11.09 | $671.5K | 11,389,451 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-22 | 2014-09-23 | 50,000 | $11.09 | $554.5K | 11,450,000 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-22 | 2014-09-23 | 335,140 | $11.08 | $3.71M | 11,500,000 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-19 | 2014-09-23 | 814,860 | $11.50 | $9.37M | 11,835,140 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-19 | 2014-09-23 | 5,900 | $11.84 | $69.9K | 12,650,000 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-19 | 2014-09-23 | 16,387 | $11.67 | $191.2K | 12,655,900 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-19 | 2014-09-23 | 327,713 | $11.65 | $3.82M | 12,672,287 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-11 | 2014-09-12 | 184,643 | $12.41 | $2.29M | 13,997,269 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-11 | 2014-09-12 | 531,352 | $12.31 | $6.54M | 13,382,357 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-11 | 2014-09-12 | 115,000 | $12.33 | $1.42M | 13,267,357 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-11 | 2014-09-12 | 17,357 | $12.32 | $213.8K | 13,250,000 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-11 | 2014-09-12 | 83,560 | $12.62 | $1.05M | 13,913,709 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-11 | 2014-09-12 | 250,000 | $12.35 | $3.09M | 13,000,000 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-11 | 2014-09-12 | 83,560 | $12.62 | $1.05M | 13,913,709 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-11 | 2014-09-12 | 184,643 | $12.41 | $2.29M | 13,997,269 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-11 | 2014-09-12 | 531,352 | $12.31 | $6.54M | 13,382,357 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-11 | 2014-09-12 | 115,000 | $12.33 | $1.42M | 13,267,357 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-11 | 2014-09-12 | 17,357 | $12.32 | $213.8K | 13,250,000 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-11 | 2014-09-12 | 250,000 | $12.35 | $3.09M | 13,000,000 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-10 | 2014-09-12 | 8,600 | $12.73 | $109.5K | 14,695,762 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-10 | 2014-09-12 | 49,057 | $12.69 | $622.5K | 14,646,705 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-10 | 2014-09-12 | 273,017 | $127013.00 | $34.68B | 14,373,688 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-10 | 2014-09-12 | 69,833 | $12.63 | $882.0K | 14,303,855 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-10 | 2014-09-12 | 121,943 | $12.61 | $1.54M | 14,181,912 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-10 | 2014-09-12 | 121,943 | $12.61 | $1.54M | 14,181,912 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-10 | 2014-09-12 | 69,833 | $12.63 | $882.0K | 14,303,855 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-10 | 2014-09-12 | 273,017 | $12.70 | $3.47M | 14,373,688 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-10 | 2014-09-12 | 49,057 | $12.69 | $622.5K | 14,646,705 | SEC↗ |
| Kolchinsky Peter | 10% Owner | S Sale | 2014-09-10 | 2014-09-12 | 8,600 | $12.73 | $109.5K | 14,695,762 | SEC↗ |
| VITULLO NICOLE | Director | J Other | 2014-09-09 | 2014-09-11 | 100,995 | — | $0 | 260,891 | SEC↗ |
| VITULLO NICOLE | Director | J Other | 2014-09-09 | 2014-09-11 | 1,200,000 | — | $0 | 4,572,968 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-09-02 | 2014-09-02 | 158,655 | $12.04 | $1.91M | 14,704,362 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-09-02 | 2014-09-02 | 1,100 | $11.93 | $13.1K | 14,966,069 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-09-02 | 2014-09-02 | 103,052 | $12.01 | $1.24M | 14,863,017 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-08-29 | 2014-09-02 | 64,000 | $11.41 | $730.2K | 14,967,169 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-08-29 | 2014-09-02 | 217,000 | $11.40 | $2.47M | 15,031,169 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-08-29 | 2014-09-02 | 46,600 | $11.45 | $533.6K | 15,248,169 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-08-29 | 2014-09-02 | 30,500 | $11.44 | $348.9K | 15,294,769 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-08-29 | 2014-09-02 | 2,635 | $11.42 | $30.1K | 15,359,229 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-08-29 | 2014-09-02 | 4,150 | $11.53 | $47.8K | 15,361,864 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-08-29 | 2014-09-02 | 33,960 | $11.41 | $387.5K | 15,325,269 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-08-28 | 2014-09-02 | 173,641 | $11.51 | $2.00M | 15,366,014 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-08-27 | 2014-08-27 | 150,100 | $11.48 | $1.72M | 15,539,655 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-08-27 | 2014-08-27 | 116,989 | $11.75 | $1.37M | 15,689,755 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-08-26 | 2014-08-27 | 312,867 | $11.77 | $3.68M | 15,806,744 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-08-26 | 2014-08-27 | 250,000 | $11.80 | $2.95M | 16,269,611 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-08-26 | 2014-08-27 | 52,361 | $11.16 | $584.3K | 16,519,611 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-08-26 | 2014-08-27 | 1,347,639 | $11.13 | $15.00M | 16,571,972 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-08-26 | 2014-08-27 | 150,000 | $11.78 | $1.77M | 16,119,611 | SEC↗ |
| Truitt Joseph | EVP, Chief Commercial Office | M Exercise deriv | 2014-08-25 | 2014-08-26 | 25,000 | — | $0 | 0 | SEC↗ |
| Truitt Joseph | EVP, Chief Commercial Office | M Exercise | 2014-08-25 | 2014-08-26 | 25,000 | $0.82 | $20.5K | 25,000 | SEC↗ |
| Truitt Joseph | EVP, Chief Commercial Office | S Sale | 2014-08-25 | 2014-08-26 | 25,000 | $10.82 | $270.5K | 0 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-08-25 | 2014-08-27 | 105,196 | $11.01 | $1.16M | 17,919,611 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | 10% Owner | S Sale | 2014-08-25 | 2014-08-27 | 226,200 | $10.94 | $2.47M | 18,024,807 | SEC↗ |
| Deshpande Milind | President and CEO | M Exercise deriv | 2014-08-18 | 2014-08-19 | 15,950 | — | $0 | 0 | SEC↗ |
| Deshpande Milind | President and CEO | M Exercise deriv | 2014-08-18 | 2014-08-19 | 60,000 | — | $0 | 0 | SEC↗ |
| Deshpande Milind | President and CEO | M Exercise deriv | 2014-08-18 | 2014-08-19 | 124,424 | — | $0 | 75,576 | SEC↗ |
| Deshpande Milind | President and CEO | M Exercise deriv | 2014-08-18 | 2014-08-19 | 16,250 | — | $0 | 0 | SEC↗ |
| RA Capital Healthcare Fund LP | 10% Owner | S Sale | 2014-08-18 | 2014-08-19 | 235,000 | $9.51 | $2.23M | 18,251,007 | SEC↗ |
| RA Capital Healthcare Fund LP | 10% Owner | S Sale | 2014-08-18 | 2014-08-19 | 50,000 | $9.75 | $487.5K | 18,486,007 | SEC↗ |
| RA Capital Healthcare Fund LP | 10% Owner | S Sale | 2014-08-18 | 2014-08-19 | 415,000 | $9.68 | $4.02M | 18,536,007 | SEC↗ |
| RA Capital Healthcare Fund LP | 10% Owner | S Sale | 2014-08-18 | 2014-08-19 | 400,000 | $9.70 | $3.88M | 18,951,007 | SEC↗ |
| RA Capital Healthcare Fund LP | 10% Owner | S Sale | 2014-08-18 | 2014-08-19 | 635,000 | $9.73 | $6.18M | 19,351,007 | SEC↗ |
| RA Capital Healthcare Fund LP | 10% Owner | S Sale | 2014-08-18 | 2014-08-19 | 258,978 | $9.57 | $2.48M | 19,986,007 | SEC↗ |
| Deshpande Milind | President and CEO | M Exercise | 2014-08-18 | 2014-08-19 | 124,424 | $3.10 | $385.7K | 124,424 | SEC↗ |
| Deshpande Milind | President and CEO | S Sale | 2014-08-18 | 2014-08-19 | 60,000 | $10.00 | $600.0K | 0 | SEC↗ |
| Deshpande Milind | President and CEO | M Exercise | 2014-08-18 | 2014-08-19 | 60,000 | $3.28 | $196.8K | 60,000 | SEC↗ |
| Deshpande Milind | President and CEO | S Sale | 2014-08-18 | 2014-08-19 | 15,950 | $10.00 | $159.5K | 0 | SEC↗ |
| Deshpande Milind | President and CEO | S Sale | 2014-08-18 | 2014-08-19 | 124,424 | $10.00 | $1.24M | 0 | SEC↗ |