Open-mkt buys · 90d
—
0 trades · 0 insiders
Open-mkt sales · 90d
—
0 trades · 0 insiders
Net · 90d
$0
Insiders on file
40
Daily buy vs sell · 90 days
No data yet.
Insiders
| Insider | Role | Trades | Bought | Sold | Last trade |
|---|---|---|---|---|---|
| Lang Peter Frederick | Chief Financial Officer | 4 | $0 | $0 | 2022-11-21 |
| Calabrese Jeffrey | Vice President of Finance | 8 | $0 | $0 | 2022-11-21 |
| KANNAN RAJ | Chief Executive Officer | 6 | $0 | $0 | 2022-11-21 |
| LaRocca John | General Counsel | 27 | $0 | $0 | 2022-11-21 |
| Croarkin Richard | Director | 19 | $0 | $0 | 2022-11-21 |
| du Toit Michael | Director | 18 | $0 | $0 | 2022-11-21 |
| Kopczynski Casey C. | Chief Scientific Officer | 75 | $0 | $5.91M | 2022-11-21 |
| McDonnell Peter J | Director | 7 | $0 | $0 | 2022-11-21 |
| McHugh Julie | Director | 18 | $0 | $0 | 2022-11-21 |
| MCGRAW BENJAMIN F III | Interim Executive Chair | 24 | $0 | $0 | 2022-11-21 |
| GRYSKA DAVID W | Director | 16 | $0 | $0 | 2022-11-21 |
| MITRO THOMAS A | President and COO | 49 | $50.0K | $11.45M | 2022-02-08 |
| Hollander David | Chief R&D Officer | 7 | $0 | $0 | 2022-02-04 |
| MCGINLEY KATHLEEN | CHRO & VP, Corp Services | 1 | $0 | $0 | 2022-01-30 |
| Staten Christopher | Interim CFO | 1 | $0 | $0 | 2021-08-14 |
| Cagle Gerald D. | Director | 32 | $419.2K | $76.3K | 2021-06-17 |
| RUBINO RICHARD J | Chief Financial Officer | 46 | $200.4K | $6.09M | 2021-02-23 |
| ANIDO VICENTE JR | Chief Executive Officer | 60 | $779.0K | $12.44M | 2021-02-23 |
| GOLDBERG MURRAY A | Director | 13 | $0 | $0 | 2020-05-18 |
| Foresite Capital Management IV, LLC | 10% Owner | 10 | $3.67M | $17.07M | 2020-02-27 |
| Tananbaum James B. | 10% Owner | 13 | $14.92M | $3.14M | 2019-12-20 |
| Foresite Capital Fund IV, L.P. | 10% Owner | 9 | $1.08M | $0 | 2019-12-03 |
| Foresite Capital Management III, LLC | 10% Owner | 3 | $2.14M | $0 | 2019-09-05 |
| DUYK GEOFFREY M | Director | 19 | $0 | $1.94M | 2017-02-15 |
| Foresite Capital Fund II, L.P. | 10% Owner | 2 | $0 | $2.02M | 2016-10-06 |
| Foresite Capital Management II, LLC | 10% Owner | 1 | $4.38M | $0 | 2016-07-22 |
| Mehra Anand | Director, 10% Owner | 22 | $2.85M | $59.31M | 2015-04-15 |
| LEVY BRIAN | Chief Medical Officer | 4 | $60.0K | $0 | 2015-02-25 |
| Clarus Ventures II GP, L.P. | 10% Owner | 2 | $0 | $5.44M | 2015-01-28 |
| LIPTAK ROBERT | 10% Owner | 4 | $0 | $3.15M | 2015-01-05 |
| Clarus Ventures II, LLC | 10% Owner | 2 | $0 | $1.51M | 2014-12-23 |
| BONDERMAN DAVID | Other | 1 | $0 | $33.76M | 2014-11-25 |
| ACMP IV LLC | 10% Owner | 1 | $0 | $0 | 2014-07-16 |
| TPG Group Holdings (SBS) Advisors, Inc. | 10% Owner | 9 | $0 | $25.16M | 2014-07-10 |
| POWELL MICHAEL | 10% Owner | 4 | $0 | $24.21M | 2014-07-10 |
| WHEELER KURT | 10% Owner | 4 | $3.21M | $0 | 2014-06-11 |
| MAZZO JAMES V | Director | 1 | $0 | $0 | 2014-06-11 |
| SOFINNOVA VENTURE PARTNERS VII L P | 10% Owner | 1 | $0 | $5.18M | 2014-05-22 |
| NOHRA GUY P | 10% Owner | 14 | $1.10M | $4.80M | 2014-05-22 |
| GALAKATOS NICHOLAS | 10% Owner | 7 | $3.21M | $0 | 2013-10-25 |
Trade history
| Insider | Role | Code | Trade | Filed | Shares | Price | Value | Owned after | |
|---|---|---|---|---|---|---|---|---|---|
| KANNAN RAJ | Chief Executive Officer | D To issuer deriv | 2022-11-21 | 2022-11-21 | 197,239 | $6.45 | $1.27M | 0 | SEC↗ |
| KANNAN RAJ | Chief Executive Officer | D To issuer deriv | 2022-11-21 | 2022-11-21 | 387,169 | $7.14 | $2.76M | 0 | SEC↗ |
| Calabrese Jeffrey | Vice President of Finance | D To issuer deriv | 2022-11-21 | 2022-11-21 | 6,257 | $4.23 | $26.5K | 0 | SEC↗ |
| Calabrese Jeffrey | Vice President of Finance | D To issuer deriv | 2022-11-21 | 2022-11-21 | 20,774 | $6.89 | $143.1K | 0 | SEC↗ |
| Croarkin Richard | Director | D To issuer deriv | 2022-11-21 | 2022-11-21 | 7,800 | $1.98 | $15.4K | 0 | SEC↗ |
| Croarkin Richard | Director | D To issuer deriv | 2022-11-21 | 2022-11-21 | 16,854 | $9.14 | $154.0K | 0 | SEC↗ |
| Croarkin Richard | Director | D To issuer deriv | 2022-11-21 | 2022-11-21 | 25,000 | $4.81 | $120.2K | 0 | SEC↗ |
| du Toit Michael | Director | D To issuer deriv | 2022-11-21 | 2022-11-21 | 7,800 | $1.98 | $15.4K | 0 | SEC↗ |
| du Toit Michael | Director | D To issuer deriv | 2022-11-21 | 2022-11-21 | 16,854 | $9.14 | $154.0K | 0 | SEC↗ |
| GRYSKA DAVID W | Director | D To issuer deriv | 2022-11-21 | 2022-11-21 | 7,800 | $1.98 | $15.4K | 0 | SEC↗ |
| GRYSKA DAVID W | Director | D To issuer deriv | 2022-11-21 | 2022-11-21 | 16,854 | $9.14 | $154.0K | 0 | SEC↗ |
| LaRocca John | General Counsel | D To issuer deriv | 2022-11-21 | 2022-11-21 | 65,941 | $6.45 | $425.3K | 0 | SEC↗ |
| Lang Peter Frederick | Chief Financial Officer | D To issuer deriv | 2022-11-21 | 2022-11-21 | 160,551 | $6.45 | $1.04M | 0 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | D To issuer deriv | 2022-11-21 | 2022-11-21 | 25,000 | $12.10 | $302.5K | 0 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | D To issuer deriv | 2022-11-21 | 2022-11-21 | 65,941 | $6.45 | $425.3K | 0 | SEC↗ |
| McDonnell Peter J | Director | D To issuer deriv | 2022-11-21 | 2022-11-21 | 16,854 | $9.14 | $154.0K | 0 | SEC↗ |
| MCGRAW BENJAMIN F III | Director | D To issuer deriv | 2022-11-21 | 2022-11-21 | 7,800 | $1.98 | $15.4K | 0 | SEC↗ |
| MCGRAW BENJAMIN F III | Director | D To issuer deriv | 2022-11-21 | 2022-11-21 | 102,412 | $3.66 | $374.8K | 0 | SEC↗ |
| MCGRAW BENJAMIN F III | Director | D To issuer deriv | 2022-11-21 | 2022-11-21 | 16,854 | $9.14 | $154.0K | 0 | SEC↗ |
| McHugh Julie | Director | D To issuer deriv | 2022-11-21 | 2022-11-21 | 16,854 | $9.14 | $154.0K | 0 | SEC↗ |
| McHugh Julie | Director | D To issuer deriv | 2022-11-21 | 2022-11-21 | 7,800 | $1.98 | $15.4K | 0 | SEC↗ |
| KANNAN RAJ | Chief Executive Officer | D To issuer | 2022-11-21 | 2022-11-21 | 215,783 | $15.25 | $3.29M | 0 | SEC↗ |
| Calabrese Jeffrey | Vice President of Finance | D To issuer | 2022-11-21 | 2022-11-21 | 18,585 | $15.25 | $283.4K | 0 | SEC↗ |
| Croarkin Richard | Director | D To issuer | 2022-11-21 | 2022-11-21 | 16,095 | $15.25 | $245.4K | 0 | SEC↗ |
| du Toit Michael | Director | D To issuer | 2022-11-21 | 2022-11-21 | 16,095 | $15.25 | $245.4K | 0 | SEC↗ |
| GRYSKA DAVID W | Director | D To issuer | 2022-11-21 | 2022-11-21 | 1,996 | $15.25 | $30.4K | 0 | SEC↗ |
| GRYSKA DAVID W | Director | D To issuer | 2022-11-21 | 2022-11-21 | 11,495 | $15.25 | $175.3K | 0 | SEC↗ |
| LaRocca John | General Counsel | D To issuer | 2022-11-21 | 2022-11-21 | 53,585 | $15.25 | $817.2K | 0 | SEC↗ |
| Lang Peter Frederick | Chief Financial Officer | D To issuer | 2022-11-21 | 2022-11-21 | 46,297 | $15.25 | $706.0K | 0 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | D To issuer | 2022-11-21 | 2022-11-21 | 280,244 | $15.25 | $4.27M | 0 | SEC↗ |
| McDonnell Peter J | Director | D To issuer | 2022-11-21 | 2022-11-21 | 7,995 | $15.25 | $121.9K | 0 | SEC↗ |
| MCGRAW BENJAMIN F III | Director | D To issuer | 2022-11-21 | 2022-11-21 | 41,984 | $15.25 | $640.3K | 0 | SEC↗ |
| McHugh Julie | Director | D To issuer | 2022-11-21 | 2022-11-21 | 16,095 | $15.25 | $245.4K | 0 | SEC↗ |
| Calabrese Jeffrey | Vice President of Finance | F Tax w/h | 2022-11-01 | 2022-11-03 | 179 | $15.22 | $2.7K | 18,585 | SEC↗ |
| Calabrese Jeffrey | Vice President of Finance | F Tax w/h | 2022-08-14 | 2022-08-16 | 265 | $11.57 | $3.1K | 18,764 | SEC↗ |
| LaRocca John | General Counsel | F Tax w/h | 2022-08-14 | 2022-08-16 | 771 | $11.57 | $8.9K | 53,585 | SEC↗ |
| Calabrese Jeffrey | Vice President of Finance | A Award deriv | 2022-07-01 | 2022-07-06 | 20,774 | — | $0 | 20,774 | SEC↗ |
| Calabrese Jeffrey | Vice President of Finance | A Award | 2022-07-01 | 2022-07-06 | 11,276 | — | $0 | 19,295 | SEC↗ |
| Calabrese Jeffrey | Vice President of Finance | F Tax w/h | 2022-07-01 | 2022-07-13 | 266 | $8.36 | $2.2K | 19,029 | SEC↗ |
| Croarkin Richard | Director | A Award deriv | 2022-06-09 | 2022-06-13 | 16,854 | — | $0 | 16,854 | SEC↗ |
| du Toit Michael | Director | A Award deriv | 2022-06-09 | 2022-06-13 | 16,854 | — | $0 | 16,854 | SEC↗ |
| GRYSKA DAVID W | Director | A Award deriv | 2022-06-09 | 2022-06-13 | 16,854 | — | $0 | 16,854 | SEC↗ |
| McDonnell Peter J | Director | A Award deriv | 2022-06-09 | 2022-06-13 | 16,854 | — | $0 | 16,854 | SEC↗ |
| MCGRAW BENJAMIN F III | Director | A Award deriv | 2022-06-09 | 2022-06-13 | 16,854 | — | $0 | 16,854 | SEC↗ |
| McHugh Julie | Director | A Award deriv | 2022-06-09 | 2022-06-13 | 16,854 | — | $0 | 16,854 | SEC↗ |
| Croarkin Richard | Director | A Award | 2022-06-09 | 2022-06-13 | 6,245 | — | $0 | 16,095 | SEC↗ |
| du Toit Michael | Director | A Award | 2022-06-09 | 2022-06-13 | 6,245 | — | $0 | 16,095 | SEC↗ |
| GRYSKA DAVID W | Director | A Award | 2022-06-09 | 2022-06-13 | 6,245 | — | $0 | 11,495 | SEC↗ |
| McDonnell Peter J | Director | A Award | 2022-06-09 | 2022-06-13 | 6,245 | — | $0 | 7,995 | SEC↗ |
| MCGRAW BENJAMIN F III | Director | A Award | 2022-06-09 | 2022-06-13 | 6,245 | — | $0 | 41,984 | SEC↗ |
| McHugh Julie | Director | A Award | 2022-06-09 | 2022-06-13 | 6,245 | — | $0 | 16,095 | SEC↗ |
| Lang Peter Frederick | Chief Financial Officer | A Award deriv | 2022-03-18 | 2022-03-22 | 160,551 | — | $0 | 160,551 | SEC↗ |
| KANNAN RAJ | Chief Executive Officer | A Award deriv | 2022-03-18 | 2022-03-22 | 197,239 | — | $0 | 197,239 | SEC↗ |
| LaRocca John | General Counsel | A Award deriv | 2022-03-18 | 2022-03-22 | 65,941 | — | $0 | 65,941 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | A Award deriv | 2022-03-18 | 2022-03-22 | 65,941 | — | $0 | 65,941 | SEC↗ |
| Lang Peter Frederick | Chief Financial Officer | A Award | 2022-03-18 | 2022-03-22 | 46,297 | — | $0 | 46,297 | SEC↗ |
| LaRocca John | General Counsel | A Award | 2022-03-18 | 2022-03-22 | 19,015 | — | $0 | 54,356 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | A Award | 2022-03-18 | 2022-03-22 | 19,015 | — | $0 | 280,244 | SEC↗ |
| MCGRAW BENJAMIN F III | Interim Executive Chair | F Tax w/h | 2022-02-28 | 2022-03-02 | 10,324 | $8.30 | $85.7K | 35,739 | SEC↗ |
| LaRocca John | General Counsel | F Tax w/h | 2022-02-19 | 2022-02-23 | 1,973 | $6.00 | $11.8K | 35,341 | SEC↗ |
| MITRO THOMAS A | President and COO | F Tax w/h | 2022-02-08 | 2022-02-09 | 1,111 | $7.33 | $8.1K | 81,418 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | F Tax w/h | 2022-02-08 | 2022-02-09 | 700 | $7.33 | $5.1K | 261,229 | SEC↗ |
| MITRO THOMAS A | President and COO | F Tax w/h | 2022-02-07 | 2022-02-09 | 1,310 | $7.24 | $9.5K | 82,529 | SEC↗ |
| LaRocca John | General Counsel | F Tax w/h | 2022-02-07 | 2022-02-09 | 768 | $7.24 | $5.6K | 37,314 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | F Tax w/h | 2022-02-07 | 2022-02-09 | 701 | $7.24 | $5.1K | 261,929 | SEC↗ |
| MITRO THOMAS A | President and COO | F Tax w/h | 2022-02-06 | 2022-02-08 | 1,435 | $7.05 | $10.1K | 83,839 | SEC↗ |
| LaRocca John | General Counsel | F Tax w/h | 2022-02-06 | 2022-02-08 | 384 | $7.05 | $2.7K | 38,082 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | F Tax w/h | 2022-02-06 | 2022-02-08 | 876 | $7.05 | $6.2K | 262,630 | SEC↗ |
| MITRO THOMAS A | President and COO | F Tax w/h | 2022-02-04 | 2022-02-08 | 1,435 | $7.05 | $10.1K | 85,274 | SEC↗ |
| LaRocca John | General Counsel | F Tax w/h | 2022-02-04 | 2022-02-08 | 1,206 | $7.05 | $8.5K | 38,466 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | F Tax w/h | 2022-02-04 | 2022-02-08 | 963 | $7.05 | $6.8K | 263,506 | SEC↗ |
| Hollander David | Chief R&D Officer | F Tax w/h | 2022-02-04 | 2022-02-08 | 927 | $7.05 | $6.5K | 30,749 | SEC↗ |
| MCGINLEY KATHLEEN | CHRO & VP, Corp Services | F Tax w/h | 2022-01-30 | 2022-02-01 | 878 | $6.92 | $6.1K | 23,993 | SEC↗ |
| KANNAN RAJ | Chief Executive Officer | A Award deriv | 2021-12-20 | 2021-12-22 | 387,169 | — | $0 | 387,169 | SEC↗ |
| KANNAN RAJ | Chief Executive Officer | A Award | 2021-12-20 | 2021-12-22 | 215,783 | — | $0 | 215,783 | SEC↗ |
| Hollander David | Chief R&D Officer | F Tax w/h | 2021-11-11 | 2021-11-15 | 2,162 | $12.06 | $26.1K | 31,676 | SEC↗ |
| MCGRAW BENJAMIN F III | Interim Executive Chair | A Award deriv | 2021-09-20 | 2021-09-22 | 102,412 | — | $0 | 102,412 | SEC↗ |
| MCGRAW BENJAMIN F III | Interim Executive Chair | A Award | 2021-09-20 | 2021-09-22 | 34,513 | — | $0 | 46,063 | SEC↗ |
| Staten Christopher | Interim CFO | F Tax w/h | 2021-08-14 | 2021-08-17 | 877 | $14.70 | $12.9K | 21,710 | SEC↗ |
| LaRocca John | General Counsel | F Tax w/h | 2021-08-14 | 2021-08-17 | 765 | $14.70 | $11.2K | 39,672 | SEC↗ |
| Croarkin Richard | Director | A Award deriv | 2021-06-17 | 2021-06-21 | 7,800 | — | $0 | 7,800 | SEC↗ |
| McDonnell Peter J | Director | A Award deriv | 2021-06-17 | 2021-06-21 | 7,800 | — | $0 | 7,800 | SEC↗ |
| Cagle Gerald D. | Director | A Award deriv | 2021-06-17 | 2021-06-21 | 7,800 | — | $0 | 7,800 | SEC↗ |
| du Toit Michael | Director | A Award deriv | 2021-06-17 | 2021-06-21 | 7,800 | — | $0 | 7,800 | SEC↗ |
| McHugh Julie | Director | A Award deriv | 2021-06-17 | 2021-06-21 | 7,800 | — | $0 | 7,800 | SEC↗ |
| MCGRAW BENJAMIN F III | Director | A Award deriv | 2021-06-17 | 2021-06-21 | 7,800 | — | $0 | 7,800 | SEC↗ |
| GRYSKA DAVID W | Director | A Award deriv | 2021-06-17 | 2021-06-21 | 7,800 | — | $0 | 7,800 | SEC↗ |
| Croarkin Richard | Director | A Award | 2021-06-17 | 2021-06-21 | 1,750 | — | $0 | 9,850 | SEC↗ |
| McDonnell Peter J | Director | A Award | 2021-06-17 | 2021-06-21 | 1,750 | — | $0 | 1,750 | SEC↗ |
| Cagle Gerald D. | Director | A Award | 2021-06-17 | 2021-06-21 | 1,750 | — | $0 | 20,050 | SEC↗ |
| du Toit Michael | Director | A Award | 2021-06-17 | 2021-06-21 | 1,750 | — | $0 | 9,850 | SEC↗ |
| McHugh Julie | Director | A Award | 2021-06-17 | 2021-06-21 | 1,750 | — | $0 | 9,850 | SEC↗ |
| MCGRAW BENJAMIN F III | Director | A Award | 2021-06-17 | 2021-06-21 | 1,750 | — | $0 | 11,550 | SEC↗ |
| GRYSKA DAVID W | Director | A Award | 2021-06-17 | 2021-06-21 | 1,750 | — | $0 | 5,250 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | F Tax w/h | 2021-02-23 | 2021-02-25 | 1,700 | $15.66 | $26.6K | 233,396 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | F Tax w/h | 2021-02-23 | 2021-02-25 | 328 | $15.66 | $5.1K | 264,469 | SEC↗ |
| MITRO THOMAS A | President and COO | F Tax w/h | 2021-02-23 | 2021-02-25 | 763 | $15.66 | $11.9K | 86,709 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | F Tax w/h | 2021-02-23 | 2021-02-25 | 410 | $15.66 | $6.4K | 353,937 | SEC↗ |
| LaRocca John | General Counsel | F Tax w/h | 2021-02-19 | 2021-02-23 | 1,542 | $15.95 | $24.6K | 40,437 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | M Exercise deriv | 2021-02-15 | 2021-02-17 | 60,651 | — | $0 | 0 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | M Exercise | 2021-02-15 | 2021-02-17 | 60,651 | $0.20 | $12.1K | 265,522 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | F Tax w/h | 2021-02-15 | 2021-02-17 | 725 | $16.41 | $11.9K | 264,797 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | F Tax w/h | 2021-02-08 | 2021-02-09 | 921 | $17.72 | $16.3K | 354,347 | SEC↗ |
| MITRO THOMAS A | President and COO | F Tax w/h | 2021-02-08 | 2021-02-09 | 1,085 | $17.72 | $19.2K | 87,472 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | F Tax w/h | 2021-02-08 | 2021-02-09 | 666 | $17.72 | $11.8K | 204,871 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | F Tax w/h | 2021-02-08 | 2021-02-09 | 2,500 | $17.72 | $44.3K | 235,096 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | F Tax w/h | 2021-02-07 | 2021-02-09 | 1,075 | $17.68 | $19.0K | 355,268 | SEC↗ |
| MITRO THOMAS A | President and COO | F Tax w/h | 2021-02-07 | 2021-02-09 | 1,229 | $17.68 | $21.7K | 88,557 | SEC↗ |
| LaRocca John | General Counsel | F Tax w/h | 2021-02-07 | 2021-02-09 | 706 | $17.68 | $12.5K | 41,979 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | F Tax w/h | 2021-02-07 | 2021-02-09 | 701 | $17.68 | $12.4K | 205,537 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | F Tax w/h | 2021-02-07 | 2021-02-09 | 2,496 | $17.68 | $44.1K | 237,596 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | F Tax w/h | 2021-02-06 | 2021-02-09 | 1,185 | $17.68 | $21.0K | 356,343 | SEC↗ |
| MITRO THOMAS A | President and COO | F Tax w/h | 2021-02-06 | 2021-02-09 | 1,438 | $17.68 | $25.4K | 89,786 | SEC↗ |
| LaRocca John | General Counsel | F Tax w/h | 2021-02-06 | 2021-02-09 | 353 | $17.68 | $6.2K | 42,685 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | F Tax w/h | 2021-02-06 | 2021-02-09 | 876 | $17.68 | $15.5K | 206,238 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | F Tax w/h | 2021-02-06 | 2021-02-09 | 2,958 | $17.68 | $52.3K | 240,092 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | A Award deriv | 2021-02-04 | 2021-02-08 | 125,000 | — | $0 | 125,000 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | A Award deriv | 2021-02-04 | 2021-02-08 | 52,000 | — | $0 | 52,000 | SEC↗ |
| MITRO THOMAS A | President and COO | A Award deriv | 2021-02-04 | 2021-02-08 | 62,500 | — | $0 | 62,500 | SEC↗ |
| LaRocca John | General Counsel | A Award deriv | 2021-02-04 | 2021-02-08 | 50,000 | — | $0 | 50,000 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | A Award deriv | 2021-02-04 | 2021-02-08 | 50,000 | — | $0 | 50,000 | SEC↗ |
| Hollander David | Chief R&D Officer | A Award deriv | 2021-02-04 | 2021-02-08 | 50,000 | — | $0 | 50,000 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | A Award | 2021-02-04 | 2021-02-08 | 28,000 | — | $0 | 243,050 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | A Award | 2021-02-04 | 2021-02-08 | 12,000 | — | $0 | 357,528 | SEC↗ |
| MITRO THOMAS A | President and COO | A Award | 2021-02-04 | 2021-02-08 | 14,000 | — | $0 | 91,224 | SEC↗ |
| LaRocca John | General Counsel | A Award | 2021-02-04 | 2021-02-08 | 11,000 | — | $0 | 43,038 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | A Award | 2021-02-04 | 2021-02-08 | 11,000 | — | $0 | 207,114 | SEC↗ |
| Hollander David | Chief R&D Officer | A Award | 2021-02-04 | 2021-02-08 | 11,000 | — | $0 | 33,838 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | S Sale | 2020-11-11 | 2020-11-12 | 22,695 | $13.01 | $295.3K | 196,114 | SEC↗ |
| Hollander David | Chief R&D Officer | F Tax w/h | 2020-11-11 | 2020-11-12 | 2,162 | $13.05 | $28.2K | 22,838 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | S Sale | 2020-11-10 | 2020-11-12 | 7,305 | $13.00 | $95.0K | 218,809 | SEC↗ |
| LaRocca John | General Counsel | F Tax w/h | 2020-08-14 | 2020-08-18 | 685 | $12.71 | $8.7K | 32,038 | SEC↗ |
| McHugh Julie | Director | A Award deriv | 2020-06-11 | 2020-06-29 | 7,800 | — | $0 | 7,800 | SEC↗ |
| MCGRAW BENJAMIN F III | Director | A Award deriv | 2020-06-11 | 2020-06-29 | 7,800 | — | $0 | 7,800 | SEC↗ |
| GRYSKA DAVID W | Director | A Award deriv | 2020-06-11 | 2020-06-29 | 7,800 | — | $0 | 7,800 | SEC↗ |
| du Toit Michael | Director | A Award deriv | 2020-06-11 | 2020-06-29 | 7,800 | — | $0 | 7,800 | SEC↗ |
| Croarkin Richard | Director | A Award deriv | 2020-06-11 | 2020-06-29 | 7,800 | — | $0 | 7,800 | SEC↗ |
| Cagle Gerald D. | Director | A Award deriv | 2020-06-11 | 2020-06-29 | 7,800 | — | $0 | 7,800 | SEC↗ |
| McHugh Julie | Director | A Award | 2020-06-11 | 2020-06-29 | 1,750 | — | $0 | 8,100 | SEC↗ |
| MCGRAW BENJAMIN F III | Director | A Award | 2020-06-11 | 2020-06-29 | 1,750 | — | $0 | 9,800 | SEC↗ |
| GRYSKA DAVID W | Director | A Award | 2020-06-11 | 2020-06-29 | 1,750 | — | $0 | 3,500 | SEC↗ |
| du Toit Michael | Director | A Award | 2020-06-11 | 2020-06-29 | 1,750 | — | $0 | 8,100 | SEC↗ |
| Croarkin Richard | Director | A Award | 2020-06-11 | 2020-06-29 | 1,750 | — | $0 | 8,100 | SEC↗ |
| Cagle Gerald D. | Director | A Award | 2020-06-11 | 2020-06-29 | 1,750 | — | $0 | 18,300 | SEC↗ |
| McDonnell Peter J | Director | A Award deriv | 2020-06-09 | 2020-06-11 | 25,000 | — | $0 | 25,000 | SEC↗ |
| GOLDBERG MURRAY A | Director | M Exercise deriv | 2020-05-18 | 2020-05-20 | 28,000 | — | $0 | 0 | SEC↗ |
| GOLDBERG MURRAY A | Director | M Exercise | 2020-05-18 | 2020-05-20 | 28,000 | $3.15 | $88.2K | 36,050 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | F Tax w/h | 2020-05-16 | 2020-05-18 | 4,746 | $14.85 | $70.5K | 215,050 | SEC↗ |
| MITRO THOMAS A | President and COO | F Tax w/h | 2020-05-16 | 2020-05-18 | 2,345 | $14.85 | $34.8K | 77,224 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | F Tax w/h | 2020-05-16 | 2020-05-18 | 2,323 | $14.85 | $34.5K | 345,528 | SEC↗ |
| Cagle Gerald D. | Director | S Sale | 2020-05-08 | 2020-05-12 | 5,000 | $15.27 | $76.3K | 16,550 | SEC↗ |
| Foresite Capital Management IV | 10% Owner | S Sale | 2020-02-27 | 2020-03-02 | 271,767 | $17.07 | $4.64M | 1,229,633 | SEC↗ |
| Foresite Capital Management IV | 10% Owner | S Sale | 2020-02-27 | 2020-03-02 | 302,776 | $17.07 | $5.17M | 1,369,938 | SEC↗ |
| Foresite Capital Management IV | 10% Owner | S Sale | 2020-02-27 | 2020-03-02 | 425,457 | $17.07 | $7.26M | 1,925,020 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | F Tax w/h | 2020-02-24 | 2020-02-25 | 1,527 | $20.30 | $31.0K | 219,796 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | F Tax w/h | 2020-02-24 | 2020-02-25 | 669 | $20.30 | $13.6K | 226,114 | SEC↗ |
| MITRO THOMAS A | President and COO | F Tax w/h | 2020-02-24 | 2020-02-25 | 1,027 | $20.30 | $20.8K | 79,569 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | F Tax w/h | 2020-02-24 | 2020-02-25 | 857 | $20.30 | $17.4K | 347,851 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | F Tax w/h | 2020-02-23 | 2020-02-25 | 1,052 | $21.59 | $22.7K | 221,323 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | F Tax w/h | 2020-02-23 | 2020-02-25 | 328 | $21.59 | $7.1K | 226,783 | SEC↗ |
| MITRO THOMAS A | President and COO | F Tax w/h | 2020-02-23 | 2020-02-25 | 763 | $21.59 | $16.5K | 80,596 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | F Tax w/h | 2020-02-23 | 2020-02-25 | 410 | $21.59 | $8.9K | 348,708 | SEC↗ |
| LaRocca John | General Counsel | F Tax w/h | 2020-02-19 | 2020-02-21 | 1,542 | $19.47 | $30.0K | 32,723 | SEC↗ |
| MITRO THOMAS A | President and COO | F Tax w/h | 2020-02-08 | 2020-02-11 | 1,183 | $20.49 | $24.2K | 81,359 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | F Tax w/h | 2020-02-08 | 2020-02-11 | 700 | $20.49 | $14.3K | 227,111 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | F Tax w/h | 2020-02-08 | 2020-02-11 | 1,546 | $20.49 | $31.7K | 222,375 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | F Tax w/h | 2020-02-08 | 2020-02-11 | 1,023 | $20.49 | $21.0K | 349,118 | SEC↗ |
| MITRO THOMAS A | President and COO | F Tax w/h | 2020-02-07 | 2020-02-11 | 1,307 | $20.49 | $26.8K | 82,542 | SEC↗ |
| LaRocca John | General Counsel | F Tax w/h | 2020-02-07 | 2020-02-11 | 693 | $20.49 | $14.2K | 34,265 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | F Tax w/h | 2020-02-07 | 2020-02-11 | 700 | $20.49 | $14.3K | 227,811 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | F Tax w/h | 2020-02-07 | 2020-02-11 | 1,710 | $20.49 | $35.0K | 223,921 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | F Tax w/h | 2020-02-07 | 2020-02-11 | 1,055 | $20.49 | $21.6K | 350,141 | SEC↗ |
| MITRO THOMAS A | President and COO | A Award deriv | 2020-02-06 | 2020-02-10 | 62,500 | — | $0 | 62,500 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | A Award deriv | 2020-02-06 | 2020-02-10 | 125,000 | — | $0 | 125,000 | SEC↗ |
| LaRocca John | General Counsel | A Award deriv | 2020-02-06 | 2020-02-10 | 15,500 | — | $0 | 15,500 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | A Award deriv | 2020-02-06 | 2020-02-10 | 52,000 | — | $0 | 52,000 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | A Award deriv | 2020-02-06 | 2020-02-10 | 45,000 | — | $0 | 45,000 | SEC↗ |
| MITRO THOMAS A | President and COO | A Award | 2020-02-06 | 2020-02-10 | 14,000 | — | $0 | 83,849 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | A Award | 2020-02-06 | 2020-02-10 | 28,000 | — | $0 | 225,631 | SEC↗ |
| LaRocca John | General Counsel | A Award | 2020-02-06 | 2020-02-10 | 3,500 | — | $0 | 34,958 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | A Award | 2020-02-06 | 2020-02-10 | 11,750 | — | $0 | 351,196 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | A Award | 2020-02-06 | 2020-02-10 | 10,000 | — | $0 | 228,511 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | W Will | 2020-01-28 | 2020-02-10 | 2,250 | — | $0 | 10,500 | SEC↗ |
| Tananbaum James B. | 10% Owner | X Exercise deriv | 2019-12-20 | 2019-12-23 | 289 | — | $0 | 0 | SEC↗ |
| Tananbaum James B. | 10% Owner | X Exercise | 2019-12-20 | 2019-12-23 | 28,900 | $30.00 | $867.0K | 1,501,400 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | M Exercise deriv | 2019-12-03 | 2019-12-05 | 117,000 | — | $0 | 0 | SEC↗ |
| Foresite Capital Fund IV, L.P. | 10% Owner | X Exercise deriv | 2019-12-03 | 2019-12-05 | 266 | — | $0 | 289 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | M Exercise | 2019-12-03 | 2019-12-05 | 117,000 | $0.41 | $48.0K | 218,511 | SEC↗ |
| Foresite Capital Fund IV, L.P. | 10% Owner | X Exercise | 2019-12-03 | 2019-12-05 | 26,600 | $30.00 | $798.0K | 1,472,500 | SEC↗ |
| Foresite Capital Fund IV, L.P. | 10% Owner | X Exercise deriv | 2019-11-26 | 2019-12-05 | 44 | — | $0 | 555 | SEC↗ |
| Foresite Capital Fund IV, L.P. | 10% Owner | X Exercise | 2019-11-26 | 2019-12-05 | 4,400 | $30.00 | $132.0K | 1,445,900 | SEC↗ |
| Foresite Capital Management IV | 10% Owner | X Exercise deriv | 2019-11-15 | 2019-11-18 | 199 | — | $0 | 599 | SEC↗ |
| Foresite Capital Management IV | 10% Owner | X Exercise | 2019-11-15 | 2019-11-18 | 19,900 | $30.00 | $597.0K | 1,441,500 | SEC↗ |
| Foresite Capital Management IV | 10% Owner | X Exercise deriv | 2019-11-14 | 2019-11-18 | 57 | — | $0 | 798 | SEC↗ |
| Foresite Capital Management IV | 10% Owner | X Exercise | 2019-11-14 | 2019-11-18 | 5,700 | $30.00 | $171.0K | 1,421,600 | SEC↗ |
| Hollander David | Chief R&D Officer | A Award deriv | 2019-11-11 | 2019-11-13 | 110,000 | — | $0 | 110,000 | SEC↗ |
| Hollander David | Chief R&D Officer | A Award | 2019-11-11 | 2019-11-13 | 25,000 | — | $0 | 25,000 | SEC↗ |
| Foresite Capital Fund IV, L.P. | 10% Owner | X Exercise deriv | 2019-11-07 | 2019-11-12 | 150 | — | $0 | 855 | SEC↗ |
| Foresite Capital Fund IV, L.P. | 10% Owner | X Exercise | 2019-11-07 | 2019-11-12 | 15,000 | $30.00 | $450.0K | 1,415,900 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | P Buy | 2019-09-09 | 2019-09-09 | 24,250 | $18.93 | $459.1K | 195,631 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | P Buy | 2019-09-09 | 2019-09-09 | 2,000 | $19.95 | $39.9K | 197,631 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | P Buy | 2019-09-09 | 2019-09-09 | 5,040 | $19.93 | $100.4K | 339,446 | SEC↗ |
| Foresite Capital Management II | 10% Owner | P Buy | 2019-09-05 | 2019-09-06 | 15,700 | $18.42 | $289.2K | 2,350,477 | SEC↗ |
| Foresite Capital Management II | 10% Owner | P Buy | 2019-09-04 | 2019-09-06 | 9,300 | $18.48 | $171.9K | 2,334,777 | SEC↗ |
| Foresite Capital Management II | 10% Owner | P Buy | 2019-09-04 | 2019-09-06 | 90,900 | $18.48 | $1.68M | 1,400,900 | SEC↗ |
| Tananbaum James B. | 10% Owner | P Buy | 2019-09-03 | 2019-09-04 | 15,100 | $21.45 | $323.9K | 2,325,477 | SEC↗ |
| Tananbaum James B. | 10% Owner | P Buy | 2019-09-03 | 2019-09-04 | 34,900 | $20.54 | $716.8K | 2,310,377 | SEC↗ |
| Tananbaum James B. | 10% Owner | P Buy | 2019-08-30 | 2019-09-04 | 25,000 | $21.36 | $534.0K | 2,275,477 | SEC↗ |
| Foresite Capital Fund IV, L.P. | 10% Owner | P Buy | 2019-08-23 | 2019-08-23 | 38,300 | $23.42 | $897.0K | 2,250,477 | SEC↗ |
| Foresite Capital Fund IV, L.P. | 10% Owner | P Buy | 2019-08-22 | 2019-08-23 | 6,700 | $23.68 | $158.7K | 2,212,177 | SEC↗ |
| Foresite Capital Fund IV, L.P. | 10% Owner | P Buy | 2019-08-21 | 2019-08-23 | 1,153 | $23.25 | $26.8K | 2,205,477 | SEC↗ |
| Foresite Capital Management IV | 10% Owner | P Buy | 2019-08-20 | 2019-08-20 | 50,000 | $23.21 | $1.16M | 2,204,324 | SEC↗ |
| Foresite Capital Management IV | 10% Owner | P Buy | 2019-08-19 | 2019-08-20 | 3,847 | $23.34 | $89.8K | 2,154,324 | SEC↗ |
| Foresite Capital Management IV | 10% Owner | P Buy | 2019-08-16 | 2019-08-20 | 100,000 | $24.23 | $2.42M | 2,150,477 | SEC↗ |
| LaRocca John | General Counsel | A Award deriv | 2019-08-14 | 2019-08-16 | 36,000 | — | $0 | 36,000 | SEC↗ |
| Tananbaum James B. | 10% Owner | P Buy | 2019-08-14 | 2019-08-14 | 100,000 | $23.73 | $2.37M | 2,050,477 | SEC↗ |
| LaRocca John | General Counsel | A Award | 2019-08-14 | 2019-08-16 | 8,000 | — | $0 | 31,458 | SEC↗ |
| Tananbaum James B. | 10% Owner | P Buy | 2019-08-13 | 2019-08-14 | 71,097 | $24.92 | $1.77M | 1,131,097 | SEC↗ |
| Tananbaum James B. | 10% Owner | P Buy | 2019-08-13 | 2019-08-14 | 178,903 | $25.52 | $4.57M | 1,310,000 | SEC↗ |
| Tananbaum James B. | 10% Owner | P Buy | 2019-08-12 | 2019-08-14 | 189,555 | $24.43 | $4.63M | 1,060,000 | SEC↗ |
| Cagle Gerald D. | Director | A Award deriv | 2019-05-23 | 2019-05-23 | 7,800 | — | $0 | 7,800 | SEC↗ |
| Croarkin Richard | Director | A Award deriv | 2019-05-23 | 2019-05-23 | 7,800 | — | $0 | 7,800 | SEC↗ |
| du Toit Michael | Director | A Award deriv | 2019-05-23 | 2019-05-23 | 7,800 | — | $0 | 7,800 | SEC↗ |
| GRYSKA DAVID W | Director | A Award deriv | 2019-05-23 | 2019-05-23 | 7,800 | — | $0 | 7,800 | SEC↗ |
| MCGRAW BENJAMIN F III | Director | A Award deriv | 2019-05-23 | 2019-05-23 | 7,800 | — | $0 | 7,800 | SEC↗ |
| McHugh Julie | Director | A Award deriv | 2019-05-23 | 2019-05-23 | 7,800 | — | $0 | 7,800 | SEC↗ |
| GOLDBERG MURRAY A | Director | A Award deriv | 2019-05-23 | 2019-05-24 | 7,800 | — | $0 | 7,800 | SEC↗ |
| Cagle Gerald D. | Director | A Award | 2019-05-23 | 2019-05-23 | 1,750 | — | $0 | 21,550 | SEC↗ |
| Croarkin Richard | Director | A Award | 2019-05-23 | 2019-05-23 | 1,750 | — | $0 | 6,350 | SEC↗ |
| du Toit Michael | Director | A Award | 2019-05-23 | 2019-05-23 | 1,750 | — | $0 | 6,350 | SEC↗ |
| GRYSKA DAVID W | Director | A Award | 2019-05-23 | 2019-05-23 | 1,750 | — | $0 | 1,750 | SEC↗ |
| MCGRAW BENJAMIN F III | Director | A Award | 2019-05-23 | 2019-05-23 | 1,750 | — | $0 | 8,050 | SEC↗ |
| McHugh Julie | Director | A Award | 2019-05-23 | 2019-05-23 | 1,750 | — | $0 | 6,350 | SEC↗ |
| GOLDBERG MURRAY A | Director | A Award | 2019-05-23 | 2019-05-24 | 1,750 | — | $0 | 8,050 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | A Award | 2019-05-16 | 2019-05-17 | 32,171 | — | $0 | 175,526 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | F Tax w/h | 2019-05-16 | 2019-05-17 | 4,145 | $40.54 | $168.0K | 171,381 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | F Tax w/h | 2019-05-16 | 2019-05-17 | 2,322 | $40.54 | $94.1K | 334,406 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | A Award | 2019-05-16 | 2019-05-17 | 13,559 | — | $0 | 336,728 | SEC↗ |
| MITRO THOMAS A | President and COO | A Award | 2019-05-16 | 2019-05-17 | 13,559 | — | $0 | 72,194 | SEC↗ |
| MITRO THOMAS A | President and COO | F Tax w/h | 2019-05-16 | 2019-05-17 | 2,345 | $40.54 | $95.1K | 69,849 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | F Tax w/h | 2019-04-12 | 2019-04-15 | 2,612 | $41.89 | $109.4K | 143,355 | SEC↗ |
| MITRO THOMAS A | President and COO | F Tax w/h | 2019-04-12 | 2019-04-15 | 1,564 | $41.89 | $65.5K | 58,635 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | F Tax w/h | 2019-04-12 | 2019-04-15 | 1,549 | $41.89 | $64.9K | 323,169 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | F Tax w/h | 2019-02-25 | 2019-02-26 | 1,562 | $40.18 | $62.8K | 145,967 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | F Tax w/h | 2019-02-25 | 2019-02-26 | 534 | $40.18 | $21.5K | 101,511 | SEC↗ |
| MITRO THOMAS A | President and COO | F Tax w/h | 2019-02-25 | 2019-02-26 | 1,027 | $40.18 | $41.3K | 60,199 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | F Tax w/h | 2019-02-25 | 2019-02-26 | 777 | $40.18 | $31.2K | 324,718 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | F Tax w/h | 2019-02-24 | 2019-02-26 | 1,527 | $40.04 | $61.1K | 147,529 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | F Tax w/h | 2019-02-24 | 2019-02-26 | 669 | $40.04 | $26.8K | 102,045 | SEC↗ |
| MITRO THOMAS A | President and COO | F Tax w/h | 2019-02-24 | 2019-02-26 | 1,027 | $40.04 | $41.1K | 61,226 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | F Tax w/h | 2019-02-24 | 2019-02-26 | 857 | $40.04 | $34.3K | 325,495 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | F Tax w/h | 2019-02-23 | 2019-02-26 | 1,053 | $40.04 | $42.2K | 149,056 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | F Tax w/h | 2019-02-23 | 2019-02-26 | 328 | $40.04 | $13.1K | 102,714 | SEC↗ |
| MITRO THOMAS A | President and COO | F Tax w/h | 2019-02-23 | 2019-02-26 | 763 | $40.04 | $30.6K | 62,253 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | F Tax w/h | 2019-02-23 | 2019-02-26 | 410 | $40.04 | $16.4K | 326,352 | SEC↗ |
| LaRocca John | General Counsel | F Tax w/h | 2019-02-19 | 2019-02-20 | 1,542 | $40.80 | $62.9K | 23,458 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | F Tax w/h | 2019-02-08 | 2019-02-11 | 1,036 | $40.39 | $41.8K | 326,762 | SEC↗ |
| MITRO THOMAS A | President and COO | F Tax w/h | 2019-02-08 | 2019-02-11 | 1,241 | $40.39 | $50.1K | 63,016 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | F Tax w/h | 2019-02-08 | 2019-02-11 | 1,624 | $40.39 | $65.6K | 150,109 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | F Tax w/h | 2019-02-08 | 2019-02-11 | 701 | $40.39 | $28.3K | 103,042 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | A Award deriv | 2019-02-07 | 2019-02-11 | 48,000 | — | $0 | 48,000 | SEC↗ |
| MITRO THOMAS A | President and COO | A Award deriv | 2019-02-07 | 2019-02-11 | 57,500 | — | $0 | 57,500 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | A Award deriv | 2019-02-07 | 2019-02-11 | 114,358 | — | $0 | 114,358 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | A Award deriv | 2019-02-07 | 2019-02-11 | 36,000 | — | $0 | 36,000 | SEC↗ |
| LaRocca John | General Counsel | A Award deriv | 2019-02-07 | 2019-02-11 | 31,000 | — | $0 | 31,000 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | A Award | 2019-02-07 | 2019-02-11 | 10,667 | — | $0 | 327,798 | SEC↗ |
| MITRO THOMAS A | President and COO | A Award | 2019-02-07 | 2019-02-11 | 12,778 | — | $0 | 64,257 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | A Award | 2019-02-07 | 2019-02-11 | 25,413 | — | $0 | 151,733 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | A Award | 2019-02-07 | 2019-02-11 | 8,000 | — | $0 | 103,743 | SEC↗ |
| LaRocca John | General Counsel | A Award | 2019-02-07 | 2019-02-11 | 7,000 | — | $0 | 25,000 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | S Sale | 2019-02-01 | 2019-02-01 | 9,500 | $46.03 | $437.3K | 97,243 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | S Sale | 2019-02-01 | 2019-02-01 | 1,500 | $47.02 | $70.5K | 95,743 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | S Sale | 2019-01-02 | 2019-01-02 | 11,000 | $35.21 | $387.3K | 106,743 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | S Sale | 2018-12-03 | 2018-12-04 | 299 | $40.55 | $12.1K | 117,743 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | S Sale | 2018-12-03 | 2018-12-04 | 10,701 | $39.79 | $425.8K | 118,042 | SEC↗ |
| Cagle Gerald D. | Director | P Buy | 2018-11-16 | 2018-11-19 | 2,000 | $41.75 | $83.5K | 19,800 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | S Sale | 2018-11-01 | 2018-11-02 | 3,208 | $52.99 | $170.0K | 136,535 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | S Sale | 2018-11-01 | 2018-11-02 | 7,792 | $54.22 | $422.5K | 128,743 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | S Sale | 2018-10-01 | 2018-10-01 | 9,330 | $60.43 | $563.8K | 138,187 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | S Sale | 2018-10-01 | 2018-10-01 | 1,670 | $61.34 | $102.4K | 136,517 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | S Sale | 2018-09-27 | 2018-09-28 | 108 | $61.01 | $6.6K | 317,131 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | S Sale | 2018-09-27 | 2018-09-28 | 16,497 | $60.36 | $995.8K | 317,239 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | S Sale | 2018-09-26 | 2018-09-28 | 49,500 | $60.18 | $2.98M | 334,236 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | S Sale | 2018-09-26 | 2018-09-28 | 500 | $61.01 | $30.5K | 333,736 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | S Sale | 2018-09-14 | 2018-09-18 | 2 | $60.00 | $120 | 383,736 | SEC↗ |
| RUBINO RICHARD J | Chief Financial Officer | S Sale | 2018-09-13 | 2018-09-14 | 34,512 | $60.17 | $2.08M | 383,738 | SEC↗ |
| GRYSKA DAVID W | Director | A Award deriv | 2018-09-12 | 2018-09-12 | 25,000 | — | $0 | 25,000 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | S Sale | 2018-09-04 | 2018-09-06 | 10,000 | $60.00 | $600.0K | 148,517 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | S Sale | 2018-09-04 | 2018-09-06 | 1,000 | $61.00 | $61.0K | 147,517 | SEC↗ |
| MITRO THOMAS A | President and COO | M Exercise deriv | 2018-08-27 | 2018-08-29 | 182,668 | — | $0 | 126,984 | SEC↗ |
| MITRO THOMAS A | President and COO | M Exercise deriv | 2018-08-27 | 2018-08-29 | 7,332 | — | $0 | 63,498 | SEC↗ |
| MITRO THOMAS A | President and COO | S Sale | 2018-08-27 | 2018-08-29 | 451 | $61.01 | $27.5K | 51,479 | SEC↗ |
| MITRO THOMAS A | President and COO | S Sale | 2018-08-27 | 2018-08-29 | 189,549 | $60.27 | $11.42M | 51,930 | SEC↗ |
| MITRO THOMAS A | President and COO | M Exercise | 2018-08-27 | 2018-08-29 | 7,332 | $3.15 | $23.1K | 241,479 | SEC↗ |
| MITRO THOMAS A | President and COO | M Exercise | 2018-08-27 | 2018-08-29 | 182,668 | $3.15 | $575.4K | 234,147 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | S Sale | 2018-08-01 | 2018-08-02 | 4,790 | $68.69 | $329.0K | 158,517 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | S Sale | 2018-08-01 | 2018-08-02 | 6,210 | $68.00 | $422.3K | 163,307 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | S Sale | 2018-07-02 | 2018-07-05 | 2,600 | $67.09 | $174.4K | 169,517 | SEC↗ |
| Kopczynski Casey C. | Chief Scientific Officer | S Sale | 2018-07-02 | 2018-07-05 | 8,400 | $66.15 | $555.7K | 172,117 | SEC↗ |
| ANIDO VICENTE JR | Chief Executive Officer | M Exercise deriv | 2018-06-11 | 2018-06-13 | 50,000 | — | $0 | 846,329 | SEC↗ |