APRE

Aprea Therapeutics, Inc.CIK 1781983 ☆ Sign in to watch Congress trades

Open-mkt buys · 90d

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0 trades · 0 insiders

Open-mkt sales · 90d

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0 trades · 0 insiders

Net · 90d

Insiders on file

AI insights for APRE PRO

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AI insights for APRE

Insider sentiment score with a plain-English explanation, conviction score on every buy, and how the stock performed 30 and 90 days after past insider buys.

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Daily buy vs sell · 90 days

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Insiders

Insider	Role	Trades	Bought	Sold	Last trade
Pamukcu Rifat	Director	14	$0	$0	2026-06-16
Duey Marc	Director	19	$157.3K	$29.6K	2026-06-16
Gruia Gabriela	Director	5	$0	$0	2026-06-16
Seizinger Bernd R.	Director	22	$149.3K	$0	2026-06-16
Grissinger Michael	Director	10	$0	$0	2026-06-16
Peters Richard	Director	15	$100.4K	$0	2026-06-16
BIZZARI JEAN-PIERRE	Director	5	$0	$0	2026-06-16
HENNEMAN JOHN B III	Director	18	$125.0K	$0	2026-06-16
Hamill John P.	SrVP/CFO/Prin. Fin&Acctg. Off	20	$44.7K	$0	2026-03-31
Gilad Oren	President/CEO	25	$80.5K	$0	2026-03-12
Mirza Nadeem Q.	Chief Medical Officer	2	$0	$0	2024-05-01
Korbel Gregory Alan	VP of Business Dev't	29	$7.5K	$544.7K	2022-07-28
Coiante Scott M	SVP, Chief Financial Officer	13	$37.5K	$0	2022-07-28
SCHADE CHRISTIAN S	President & CEO	19	$189.0K	$0	2022-07-28
Attar Eyal C.	SVP, Chief Medical Officer	13	$6.0K	$137.0K	2022-06-03
Abrahmsen Lars B.	SVP, Chief Scientific Officer	12	$0	$368.8K	2022-03-10
Namouni Fouad	Director	3	$0	$0	2021-06-30
Kelly Michael Aaron	Director	3	$0	$0	2021-06-30
Wessels Gregory S.	SVP, Chief Commercial Officer	3	$0	$0	2021-02-25
Redmile Group, LLC	10% Owner	5	$6.00M	$2.79M	2020-12-28
5AM Opportunities I (GP), LLC	Other	4	$0	$9.09M	2020-10-05
KCIF Co-Investment Fund KB	10% Owner	1	$0	$8.35M	2020-07-07
Hepple Jonathan	Director	1	$0	$0	2020-06-30
Christenson Johan	Director	6	$4.00M	$0	2020-06-30
ROCKLAGE SCOTT M	Director, 10% Owner	15	$0	$20.01M	2020-06-30
5AM Partners IV, LLC	10% Owner	4	$0	$16.01M	2020-06-11
Versant Vantage I GP, L.P.	10% Owner	5	$0	$0	2020-05-18
Versant Ophthalmic Affiliates I, L.P.	10% Owner	13	$0	$0	2020-05-18
KDev Investments AB	10% Owner	5	$0	$6.58M	2020-04-13
Versant Vantage I GP-GP, LLC	10% Owner	5	$5.00M	$0	2019-10-07
HealthCap VII, L.P.	10% Owner	5	$4.00M	$0	2019-10-07
Versant Ventures V GP-GP (Canada), Inc.	10% Owner	5	$5.00M	$0	2019-10-07
5AM Ventures IV, L.P.	10% Owner	9	$5.00M	$0	2019-10-07
Magni Guido	Director	1	$97.5K	$0	2019-10-07

Trade history

Insider	Role	Code	Trade	Filed	Shares	Price	Value	Owned after
Seizinger Bernd R.	Director	A Award deriv	2026-06-16	2026-06-17	12,555	—	$0	12,555	SEC↗
Pamukcu Rifat	Director	A Award deriv	2026-06-16	2026-06-17	12,555	—	$0	12,555	SEC↗
Duey Marc	Director	A Award deriv	2026-06-16	2026-06-17	12,555	—	$0	12,555	SEC↗
BIZZARI JEAN-PIERRE	Director	A Award deriv	2026-06-16	2026-06-17	12,555	—	$0	12,555	SEC↗
HENNEMAN JOHN B III	Director	A Award deriv	2026-06-16	2026-06-17	12,555	—	$0	12,555	SEC↗
Peters Richard	Director	A Award deriv	2026-06-16	2026-06-17	12,555	—	$0	12,555	SEC↗
Gruia Gabriela	Director	A Award deriv	2026-06-16	2026-06-17	12,555	—	$0	12,555	SEC↗
Grissinger Michael	Director	A Award deriv	2026-06-16	2026-06-17	12,555	—	$0	12,555	SEC↗
Seizinger Bernd R.	Director	A Award	2026-06-16	2026-06-17	3,135	—	$0	48,910	SEC↗
Pamukcu Rifat	Director	A Award	2026-06-16	2026-06-17	3,135	—	$0	8,581	SEC↗
Duey Marc	Director	A Award	2026-06-16	2026-06-17	3,135	—	$0	259,290	SEC↗
BIZZARI JEAN-PIERRE	Director	A Award	2026-06-16	2026-06-17	3,135	—	$0	4,180	SEC↗
HENNEMAN JOHN B III	Director	A Award	2026-06-16	2026-06-17	3,135	—	$0	13,364	SEC↗
Peters Richard	Director	A Award	2026-06-16	2026-06-17	3,135	—	$0	6,254	SEC↗
Gruia Gabriela	Director	A Award	2026-06-16	2026-06-17	3,135	—	$0	4,180	SEC↗
Grissinger Michael	Director	A Award	2026-06-16	2026-06-17	3,135	—	$0	6,024	SEC↗
Peters Richard	Director	P Buy deriv	2026-03-31	2026-04-01	123,915	—	$0	123,915	SEC↗
Peters Richard	Director	P Buy deriv	2026-03-31	2026-04-01	123,915	$0.81	$100.4K	123,915	SEC↗
Hamill John P.	SrVP/CFO/Prin Fin & Acct Ofc	P Buy deriv	2026-03-31	2026-04-01	30,978	—	$0	30,978	SEC↗
Hamill John P.	SrVP/CFO/Prin Fin & Acct Ofc	P Buy deriv	2026-03-31	2026-04-01	30,978	$0.81	$25.1K	30,978	SEC↗
Hamill John P.	SrVP/CFO/Prin Fin & Acct Ofc	A Award deriv	2026-03-12	2026-03-16	40,380	—	$0	40,380	SEC↗
Gilad Oren	President/CEO	A Award deriv	2026-03-12	2026-03-16	80,700	—	$0	80,700	SEC↗
Hamill John P.	SrVP/CFO/Prin Fin & Acct Ofc	A Award	2026-03-12	2026-03-16	10,095	—	$0	43,528	SEC↗
Gilad Oren	President/CEO	A Award	2026-03-12	2026-03-16	20,175	—	$0	393,895	SEC↗
Hamill John P.	SrVP/CFO/Prin Fin & Acct Ofc	P Buy deriv	2026-01-30	2026-02-02	5,700	—	$0	5,700	SEC↗
Gilad Oren	President/CEO	P Buy deriv	2026-01-30	2026-02-02	28,100	—	$0	28,100	SEC↗
Hamill John P.	SrVP/CFO/Prin Fin & Acct Ofc	P Buy	2026-01-30	2026-02-02	5,700	$0.89	$5.1K	33,433	SEC↗
Gilad Oren	President/CEO	P Buy	2026-01-30	2026-02-02	28,100	$0.89	$25.0K	373,720	SEC↗
Gilad Oren	President/CEO	P Buy deriv	2025-12-10	2025-12-11	21,459	$1.17	$25.1K	21,459	SEC↗
Gilad Oren	President/CEO	P Buy deriv	2025-12-10	2025-12-11	21,459	—	$0	21,459	SEC↗
Hamill John P.	SrVP/CFO/Prin Fin & Acct Ofc	P Buy deriv	2025-12-10	2025-12-11	5,000	—	$0	5,000	SEC↗
Duey Marc	Director	P Buy deriv	2025-12-10	2025-12-11	21,459	—	$0	21,459	SEC↗
Hamill John P.	SrVP/CFO/Prin Fin & Acct Ofc	P Buy	2025-12-10	2025-12-11	5,000	$1.17	$5.8K	27,733	SEC↗
Duey Marc	Director	P Buy	2025-12-10	2025-12-11	21,459	$1.17	$25.1K	256,155	SEC↗
BIZZARI JEAN-PIERRE	Director	A Award deriv	2025-06-05	2025-06-09	4,185	—	$0	4,185	SEC↗
Duey Marc	Director	A Award deriv	2025-06-05	2025-06-09	4,185	—	$0	4,185	SEC↗
Grissinger Michael	Director	A Award deriv	2025-06-05	2025-06-09	4,185	—	$0	4,185	SEC↗
Gruia Gabriela	Director	A Award deriv	2025-06-05	2025-06-09	4,185	—	$0	4,185	SEC↗
HENNEMAN JOHN B III	Director	A Award deriv	2025-06-05	2025-06-09	4,185	—	$0	4,185	SEC↗
Pamukcu Rifat	Director	A Award deriv	2025-06-05	2025-06-09	4,185	—	$0	4,185	SEC↗
Peters Richard	Director	A Award deriv	2025-06-05	2025-06-09	4,185	—	$0	4,185	SEC↗
Seizinger Bernd R.	Director	A Award deriv	2025-06-05	2025-06-09	4,185	—	$0	4,185	SEC↗
BIZZARI JEAN-PIERRE	Director	A Award	2025-06-05	2025-06-09	1,045	—	$0	1,045	SEC↗
Duey Marc	Director	A Award	2025-06-05	2025-06-09	1,045	—	$0	234,696	SEC↗
Grissinger Michael	Director	A Award	2025-06-05	2025-06-09	1,045	—	$0	2,889	SEC↗
Gruia Gabriela	Director	A Award	2025-06-05	2025-06-09	1,045	—	$0	1,045	SEC↗
HENNEMAN JOHN B III	Director	A Award	2025-06-05	2025-06-09	1,045	—	$0	10,229	SEC↗
Pamukcu Rifat	Director	A Award	2025-06-05	2025-06-09	1,045	—	$0	5,446	SEC↗
Peters Richard	Director	A Award	2025-06-05	2025-06-09	1,045	—	$0	3,119	SEC↗
Seizinger Bernd R.	Director	A Award	2025-06-05	2025-06-09	1,045	—	$0	45,775	SEC↗
Gilad Oren	President/CEO	P Buy	2025-04-03	2025-04-04	3,003	$1.87	$5.6K	343,123	SEC↗
Gilad Oren	President/CEO	P Buy	2025-04-03	2025-04-04	2,497	$1.80	$4.5K	345,620	SEC↗
Gilad Oren	President/CEO	A Award deriv	2025-03-27	2025-03-31	26,900	—	$0	26,900	SEC↗
Hamill John P.	SrVP/CFO/Prin Fin & Acct Ofc	A Award deriv	2025-03-27	2025-03-31	13,460	—	$0	13,460	SEC↗
Gilad Oren	President/CEO	A Award	2025-03-27	2025-03-31	6,725	—	$0	340,120	SEC↗
Hamill John P.	SrVP/CFO/Prin Fin & Acct Ofc	A Award	2025-03-27	2025-03-31	3,365	—	$0	22,733	SEC↗
Gilad Oren	President/CEO	P Buy	2024-10-23	2024-10-24	500	$3.92	$2.0K	333,395	SEC↗
Duey Marc	Director	S Sale	2024-10-18	2024-10-25	6,462	$4.58	$29.6K	233,651	SEC↗
Duey Marc	Director	P Buy	2024-10-16	2024-10-17	30,000	$4.39	$131.7K	240,113	SEC↗
Gilad Oren	President/CEO	P Buy	2024-10-15	2024-10-16	250	$2.90	$725	332,895	SEC↗
Gilad Oren	President/CEO	P Buy	2024-10-14	2024-10-15	1,000	$2.59	$2.6K	332,645	SEC↗
Duey Marc	Director	P Buy	2024-10-14	2024-10-16	190	$2.58	$490	210,113	SEC↗
Seizinger Bernd R.	Director	P Buy	2024-10-11	2024-10-15	10,000	$2.68	$26.8K	44,730	SEC↗
Hamill John P.	SrVP/CFO/Prin Fin & Acct Ofc	P Buy	2024-10-11	2024-10-16	50	$2.46	$123	19,368	SEC↗
Hamill John P.	SrVP/CFO/Prin Fin & Acct Ofc	P Buy	2024-10-10	2024-10-15	450	$2.61	$1.2K	19,318	SEC↗
Gilad Oren	President/CEO	P Buy	2024-10-10	2024-10-15	150	$2.54	$381	331,645	SEC↗
Duey Marc	Director	A Award deriv	2024-06-20	2024-06-21	4,185	—	$0	4,185	SEC↗
Grissinger Michael	Director	A Award deriv	2024-06-20	2024-06-21	4,185	—	$0	4,185	SEC↗
HENNEMAN JOHN B III	Director	A Award deriv	2024-06-20	2024-06-21	4,185	—	$0	4,185	SEC↗
Peters Richard	Director	A Award deriv	2024-06-20	2024-06-21	4,185	—	$0	4,185	SEC↗
Pamukcu Rifat	Director	A Award deriv	2024-06-20	2024-06-21	4,185	—	$0	4,185	SEC↗
Seizinger Bernd R.	Director	A Award deriv	2024-06-20	2024-06-21	4,185	—	$0	4,185	SEC↗
Duey Marc	Director	A Award	2024-06-20	2024-06-21	1,045	—	$0	209,923	SEC↗
Grissinger Michael	Director	A Award	2024-06-20	2024-06-21	1,045	—	$0	1,844	SEC↗
HENNEMAN JOHN B III	Director	A Award	2024-06-20	2024-06-21	1,045	—	$0	9,184	SEC↗
Peters Richard	Director	A Award	2024-06-20	2024-06-21	1,045	—	$0	2,074	SEC↗
Pamukcu Rifat	Director	A Award	2024-06-20	2024-06-21	1,045	—	$0	4,401	SEC↗
Seizinger Bernd R.	Director	A Award	2024-06-20	2024-06-21	1,045	—	$0	34,730	SEC↗
Mirza Nadeem Q.	Chief Medical Officer	A Award deriv	2024-05-01	2024-05-02	26,920	—	$0	26,920	SEC↗
Mirza Nadeem Q.	Chief Medical Officer	A Award	2024-05-01	2024-05-02	6,730	—	$0	6,730	SEC↗
Gilad Oren	President, CEO	A Award deriv	2024-03-28	2024-03-28	26,900	—	$0	26,900	SEC↗
Hamill John P.	SrVP/CFO/Prin Fin & Acct Ofc	A Award deriv	2024-03-28	2024-03-28	13,460	—	$0	13,460	SEC↗
Gilad Oren	President, CEO	A Award	2024-03-28	2024-03-28	6,725	—	$0	331,495	SEC↗
Hamill John P.	SrVP/CFO/Prin Fin & Acct Ofc	A Award	2024-03-28	2024-03-28	3,365	—	$0	18,868	SEC↗
Gilad Oren	President, CEO	P Buy deriv	2024-03-13	2024-03-14	1,000	—	$0	1,000	SEC↗
Gilad Oren	President, CEO	P Buy deriv	2024-03-13	2024-03-14	1,000	—	$0	1,000	SEC↗
HENNEMAN JOHN B III	Director	P Buy deriv	2024-03-13	2024-03-14	3,430	—	$0	3,430	SEC↗
HENNEMAN JOHN B III	Director	P Buy deriv	2024-03-13	2024-03-14	3,430	—	$0	3,430	SEC↗
Seizinger Bernd R.	Director	P Buy deriv	2024-03-13	2024-03-14	3,430	—	$0	3,430	SEC↗
Seizinger Bernd R.	Director	P Buy deriv	2024-03-13	2024-03-14	3,430	—	$0	3,430	SEC↗
Hamill John P.	SrVP/CFO/Prin Fin & Acct Ofc	P Buy deriv	2024-03-13	2024-03-14	505	—	$0	505	SEC↗
Hamill John P.	SrVP/CFO/Prin Fin & Acct Ofc	P Buy deriv	2024-03-13	2024-03-14	505	—	$0	505	SEC↗
Gilad Oren	President, CEO	P Buy	2024-03-13	2024-03-14	2,000	$7.29	$14.6K	324,770	SEC↗
HENNEMAN JOHN B III	Director	P Buy	2024-03-13	2024-03-14	6,860	$7.29	$50.0K	8,139	SEC↗
Seizinger Bernd R.	Director	P Buy	2024-03-13	2024-03-14	6,860	$7.29	$50.0K	33,685	SEC↗
Hamill John P.	SrVP/CFO/Prin Fin & Acct Ofc	P Buy	2024-03-13	2024-03-14	1,010	$7.29	$7.4K	15,503	SEC↗
BIZZARI JEAN-PIERRE	Director	A Award deriv	2023-08-23	2023-08-24	12,500	—	$0	12,500	SEC↗
Seizinger Bernd R.	Director	A Award deriv	2023-08-23	2023-08-24	2,000	—	$0	2,000	SEC↗
Duey Marc	Director	A Award deriv	2023-08-23	2023-08-24	2,000	—	$0	2,000	SEC↗
Peters Richard	Director	A Award deriv	2023-08-23	2023-08-24	2,000	—	$0	2,000	SEC↗
HENNEMAN JOHN B III	Director	A Award deriv	2023-08-23	2023-08-24	2,000	—	$0	2,000	SEC↗
Grissinger Michael	Director	A Award deriv	2023-08-23	2023-08-24	2,000	—	$0	2,000	SEC↗
Pamukcu Rifat	Director	A Award deriv	2023-08-23	2023-08-24	2,000	—	$0	2,000	SEC↗
Seizinger Bernd R.	Director	A Award	2023-08-23	2023-08-24	500	—	$0	26,825	SEC↗
Duey Marc	Director	A Award	2023-08-23	2023-08-24	500	—	$0	208,878	SEC↗
Peters Richard	Director	A Award	2023-08-23	2023-08-24	500	—	$0	1,029	SEC↗
HENNEMAN JOHN B III	Director	A Award	2023-08-23	2023-08-24	500	—	$0	1,279	SEC↗
Grissinger Michael	Director	A Award	2023-08-23	2023-08-24	500	—	$0	799	SEC↗
Pamukcu Rifat	Director	A Award	2023-08-23	2023-08-24	500	—	$0	3,356	SEC↗
Seizinger Bernd R.	Director	P Buy	2023-06-07	2023-06-08	6,029	$3.68	$22.2K	26,325	SEC↗
Seizinger Bernd R.	Director	P Buy	2023-06-06	2023-06-08	4,068	$3.63	$14.8K	20,296	SEC↗
Gruia Gabriela	Director	A Award deriv	2023-05-05	2023-05-08	12,500	—	$0	12,500	SEC↗
Gilad Oren	President, CEO	A Award deriv	2023-03-09	2023-03-13	16,000	—	$0	16,000	SEC↗
Gilad Oren	President, CEO	A Award	2023-03-09	2023-03-13	4,000	—	$0	322,770	SEC↗
Hamill John P.	SrVP/CFO/Prin Fin & Acct Ofc	A Award	2023-02-27	2023-02-27	1,000	$5.25	$5.3K	14,493	SEC↗
Hamill John P.	SrVP/CFO/Prin. Fin&Acctg. Of	A Award deriv	2023-01-30	2023-01-30	539,758	—	$0	539,758	SEC↗
Hamill John P.	SrVP/CFO/Prin. Fin&Acctg. Of	A Award	2023-01-30	2023-01-30	269,879	—	$0	269,879	SEC↗
Duey Marc	Director	C Conversion deriv	2022-08-23	2023-08-24	1,161	—	$0	0	SEC↗
Duey Marc	Director	C Conversion deriv	2022-08-23	2023-08-24	400,969	—	$0	0	SEC↗
Pamukcu Rifat	Director	C Conversion deriv	2022-08-23	2023-08-24	27,187	—	$0	0	SEC↗
Pamukcu Rifat	Director	C Conversion deriv	2022-08-23	2023-08-24	4,928	—	$0	0	SEC↗
Duey Marc	Director	C Conversion	2022-08-23	2023-08-24	4,009,690	—	$0	4,167,589	SEC↗
Duey Marc	Director	C Conversion	2022-08-23	2023-08-24	11,610	—	$0	602	SEC↗
Pamukcu Rifat	Director	C Conversion	2022-08-23	2023-08-24	271,870	—	$0	14,108	SEC↗
Pamukcu Rifat	Director	C Conversion	2022-08-23	2023-08-24	49,280	—	$0	57,142	SEC↗
Gilad Oren	President, CEO	C Conversion deriv	2022-08-23	2023-03-13	604,510	—	$0	0	SEC↗
Gilad Oren	President, CEO	C Conversion	2022-08-23	2023-03-13	6,045,100	—	$0	6,375,414	SEC↗
Coiante Scott M	SVP, Chief Financial Officer	A Award deriv	2022-07-28	2022-08-01	89,200	—	$0	89,200	SEC↗
Duey Marc	Director	A Award deriv	2022-07-28	2022-08-01	29,575	—	$0	29,575	SEC↗
Gilad Oren	President, CEO	A Award deriv	2022-07-28	2022-08-01	148,700	—	$0	148,700	SEC↗
Grissinger Michael	Director	A Award deriv	2022-07-28	2022-08-01	29,575	—	$0	29,575	SEC↗
HENNEMAN JOHN B III	Director	A Award deriv	2022-07-28	2022-08-01	29,575	—	$0	29,575	SEC↗
Korbel Gregory Alan	SVP, Chief Operating Officer	A Award deriv	2022-07-28	2022-08-01	35,700	—	$0	35,700	SEC↗
Pamukcu Rifat	Director	A Award deriv	2022-07-28	2022-08-01	29,575	—	$0	29,575	SEC↗
Peters Richard	Director	A Award deriv	2022-07-28	2022-08-01	29,575	—	$0	29,575	SEC↗
SCHADE CHRISTIAN S	Director	A Award deriv	2022-07-28	2022-08-01	47,600	—	$0	47,600	SEC↗
Seizinger Bernd R.	Director	A Award deriv	2022-07-28	2022-08-01	29,575	—	$0	29,575	SEC↗
Coiante Scott M	SVP, Chief Financial Officer	A Award	2022-07-28	2022-08-01	60,800	—	$0	145,065	SEC↗
Duey Marc	Director	A Award	2022-07-28	2022-08-01	5,995	—	$0	157,899	SEC↗
Gilad Oren	President, CEO	A Award	2022-07-28	2022-08-01	101,300	—	$0	330,314	SEC↗
Grissinger Michael	Director	A Award	2022-07-28	2022-08-01	5,995	—	$0	5,995	SEC↗
HENNEMAN JOHN B III	Director	A Award	2022-07-28	2022-08-01	5,995	—	$0	15,605	SEC↗
Korbel Gregory Alan	SVP, Chief Operating Officer	A Award	2022-07-28	2022-08-01	24,300	—	$0	45,762	SEC↗
Pamukcu Rifat	Director	A Award	2022-07-28	2022-08-01	5,995	—	$0	7,862	SEC↗
Peters Richard	Director	A Award	2022-07-28	2022-08-01	5,995	—	$0	10,605	SEC↗
SCHADE CHRISTIAN S	Director	A Award	2022-07-28	2022-08-01	32,400	—	$0	259,246	SEC↗
Seizinger Bernd R.	Director	A Award	2022-07-28	2022-08-01	5,995	—	$0	324,575	SEC↗
Attar Eyal C.	SVP, Chief Medical Officer	F Tax w/h	2022-06-03	2022-06-07	32,667	$0.81	$26.5K	57,233	SEC↗
Korbel Gregory Alan	SVP, Chief Operating Officer	F Tax w/h	2022-06-03	2022-06-07	8,390	$0.81	$6.8K	21,462	SEC↗
Coiante Scott M	SVP, Chief Financial Officer	F Tax w/h	2022-06-03	2022-06-07	35,284	$0.81	$28.6K	84,265	SEC↗
SCHADE CHRISTIAN S	Chairman & CEO	F Tax w/h	2022-06-03	2022-06-07	65,770	$0.81	$53.3K	226,846	SEC↗
SCHADE CHRISTIAN S	Chairman & CEO	P Buy	2022-05-18	2022-05-19	37,500	$0.64	$24.0K	292,616	SEC↗
Seizinger Bernd R.	Director	P Buy	2022-05-18	2022-05-19	50,000	$0.71	$35.5K	318,580	SEC↗
Abrahmsen Lars B.	SVP, Chief Scientific Office	A Award deriv	2022-03-10	2022-03-14	100,000	—	$0	100,000	SEC↗
Attar Eyal C.	SVP, Chief Medical Officer	A Award deriv	2022-03-10	2022-03-14	185,900	—	$0	185,900	SEC↗
Coiante Scott M	SVP, Chief Financial Officer	A Award deriv	2022-03-10	2022-03-14	185,900	—	$0	185,900	SEC↗
Korbel Gregory Alan	SVP, Chief Business Officer	A Award deriv	2022-03-10	2022-03-14	72,600	—	$0	72,600	SEC↗
SCHADE CHRISTIAN S	Chairman & CEO	A Award deriv	2022-03-10	2022-03-14	427,700	—	$0	427,700	SEC↗
Abrahmsen Lars B.	SVP, Chief Scientific Office	A Award	2022-03-10	2022-03-14	24,700	—	$0	43,700	SEC↗
Attar Eyal C.	SVP, Chief Medical Officer	A Award	2022-03-10	2022-03-14	42,900	—	$0	89,900	SEC↗
Coiante Scott M	SVP, Chief Financial Officer	A Award	2022-03-10	2022-03-14	42,900	—	$0	119,549	SEC↗
Korbel Gregory Alan	SVP, Chief Business Officer	A Award	2022-03-10	2022-03-14	16,000	—	$0	31,841	SEC↗
Korbel Gregory Alan	SVP, Chief Business Officer	F Tax w/h	2022-03-10	2022-03-14	1,989	$1.82	$3.6K	29,852	SEC↗
SCHADE CHRISTIAN S	Chairman & CEO	A Award	2022-03-10	2022-03-14	100,100	—	$0	255,116	SEC↗
Attar Eyal C.	SVP, Chief Medical Officer	S Sale	2022-02-28	2022-03-01	36,000	$1.73	$62.3K	47,000	SEC↗
Coiante Scott M	SVP, Chief Financial Officer	F Tax w/h	2022-02-25	2022-03-01	14,817	$1.74	$25.8K	76,649	SEC↗
Korbel Gregory Alan	SVP, Chief Business Officer	F Tax w/h	2022-02-25	2022-03-01	1,326	$1.74	$2.3K	15,841	SEC↗
SCHADE CHRISTIAN S	Chairman & CEO	F Tax w/h	2022-02-25	2022-03-01	21,644	$1.74	$37.7K	155,016	SEC↗
Korbel Gregory Alan	SVP, Chief Business Officer	M Exercise deriv	2021-12-01	2021-12-03	27,500	—	$0	2,335	SEC↗
Korbel Gregory Alan	SVP, Chief Business Officer	S Sale	2021-12-01	2021-12-03	27,500	$3.96	$108.9K	17,167	SEC↗
Korbel Gregory Alan	SVP, Chief Business Officer	M Exercise	2021-12-01	2021-12-03	27,500	$0.92	$25.3K	44,667	SEC↗
Korbel Gregory Alan	SVP, Chief Business Officer	M Exercise deriv	2021-11-01	2021-11-03	2,255	—	$0	29,835	SEC↗
Korbel Gregory Alan	SVP, Chief Business Officer	M Exercise deriv	2021-11-01	2021-11-03	25,245	—	$0	0	SEC↗
Korbel Gregory Alan	SVP, Chief Business Officer	M Exercise	2021-11-01	2021-11-03	27,500	$0.92	$25.3K	44,667	SEC↗
Korbel Gregory Alan	SVP, Chief Business Officer	S Sale	2021-11-01	2021-11-03	27,500	$5.00	$137.5K	17,167	SEC↗
Korbel Gregory Alan	SVP, Chief Business Officer	M Exercise deriv	2021-10-01	2021-10-05	27,500	—	$0	25,245	SEC↗
Abrahmsen Lars B.	SVP, Chief Scientific Office	M Exercise deriv	2021-10-01	2021-10-05	50,000	—	$0	30,587	SEC↗
Korbel Gregory Alan	SVP, Chief Business Officer	M Exercise	2021-10-01	2021-10-05	27,500	$0.92	$25.3K	44,667	SEC↗
Korbel Gregory Alan	SVP, Chief Business Officer	S Sale	2021-10-01	2021-10-05	27,500	$4.89	$134.5K	17,167	SEC↗
Abrahmsen Lars B.	SVP, Chief Scientific Office	M Exercise	2021-10-01	2021-10-05	50,000	$0.92	$46.0K	69,000	SEC↗
Abrahmsen Lars B.	SVP, Chief Scientific Office	S Sale	2021-10-01	2021-10-05	50,000	$4.89	$244.5K	19,000	SEC↗
Abrahmsen Lars B.	SVP, Chief Scientific Office	M Exercise deriv	2021-09-20	2021-09-22	25,000	—	$0	80,587	SEC↗
Korbel Gregory Alan	SVP, Chief Business Officer	M Exercise deriv	2021-09-20	2021-09-22	27,500	—	$0	52,745	SEC↗
Abrahmsen Lars B.	SVP, Chief Scientific Office	M Exercise	2021-09-20	2021-09-22	25,000	$0.92	$23.0K	44,000	SEC↗
Abrahmsen Lars B.	SVP, Chief Scientific Office	S Sale	2021-09-20	2021-09-22	25,000	$4.97	$124.3K	19,000	SEC↗
Korbel Gregory Alan	SVP, Chief Business Officer	M Exercise	2021-09-20	2021-09-22	27,500	$0.92	$25.3K	44,667	SEC↗
Korbel Gregory Alan	SVP, Chief Business Officer	S Sale	2021-09-20	2021-09-22	27,500	$4.97	$136.7K	17,167	SEC↗
Korbel Gregory Alan	SVP, Chief Business Officer	S Sale	2021-09-20	2021-09-22	5,460	$4.98	$27.2K	17,167	SEC↗
Attar Eyal C.	SVP, Chief Medical Officer	S Sale	2021-09-16	2021-09-20	15,968	$4.68	$74.7K	83,000	SEC↗
Korbel Gregory Alan	Chief Business Officer	F Tax w/h	2021-09-10	2021-09-14	1,724	$4.59	$7.9K	22,627	SEC↗
Attar Eyal C.	SVP, Chief Medical Officer	F Tax w/h	2021-08-25	2021-08-27	9,032	$3.98	$35.9K	98,968	SEC↗
Coiante Scott M	SVP, Chief Financial Officer	F Tax w/h	2021-08-25	2021-08-27	7,534	$3.98	$30.0K	91,466	SEC↗
Korbel Gregory Alan	Chief Business Officer	F Tax w/h	2021-08-25	2021-08-27	1,149	$3.98	$4.6K	24,351	SEC↗
Namouni Fouad	Director	A Award deriv	2021-06-30	2021-07-01	22,750	—	$0	22,750	SEC↗
Seizinger Bernd R.	Director	A Award deriv	2021-06-30	2021-07-01	22,750	—	$0	22,750	SEC↗
Peters Richard	Director	A Award deriv	2021-06-30	2021-07-01	22,750	—	$0	22,750	SEC↗
Kelly Michael Aaron	Director	A Award deriv	2021-06-30	2021-07-01	22,750	—	$0	22,750	SEC↗
HENNEMAN JOHN B III	Director	A Award deriv	2021-06-30	2021-07-01	22,750	—	$0	22,750	SEC↗
Namouni Fouad	Director	A Award	2021-06-30	2021-07-01	4,610	—	$0	4,610	SEC↗
Seizinger Bernd R.	Director	A Award	2021-06-30	2021-07-01	4,610	—	$0	268,580	SEC↗
Peters Richard	Director	A Award	2021-06-30	2021-07-01	4,610	—	$0	4,610	SEC↗
Kelly Michael Aaron	Director	A Award	2021-06-30	2021-07-01	4,610	—	$0	4,610	SEC↗
HENNEMAN JOHN B III	Director	A Award	2021-06-30	2021-07-01	4,610	—	$0	9,610	SEC↗
Korbel Gregory Alan	Chief Business Officer	A Award	2021-03-10	2021-03-11	15,000	—	$0	25,500	SEC↗
Korbel Gregory Alan	VP of Business Dev't	A Award deriv	2021-02-25	2021-03-01	41,100	—	$0	41,100	SEC↗
Coiante Scott M	SVP, Chief Financial Officer	A Award deriv	2021-02-25	2021-03-01	143,000	—	$0	143,000	SEC↗
SCHADE CHRISTIAN S	Chairman & CEO	A Award deriv	2021-02-25	2021-03-01	329,000	—	$0	329,000	SEC↗
Abrahmsen Lars B.	SVP, Chief Scientific Office	A Award deriv	2021-02-25	2021-03-01	82,000	—	$0	82,000	SEC↗
Wessels Gregory S.	SVP, Chief Commercial Office	A Award deriv	2021-02-25	2021-03-01	66,000	—	$0	66,000	SEC↗
Attar Eyal C.	SVP, Chief Medical Officer	A Award deriv	2021-02-25	2021-03-01	143,000	—	$0	143,000	SEC↗
Korbel Gregory Alan	VP of Business Dev't	A Award	2021-02-25	2021-03-01	10,000	—	$0	10,500	SEC↗
Coiante Scott M	SVP, Chief Financial Officer	A Award	2021-02-25	2021-03-01	63,500	—	$0	99,000	SEC↗
Coiante Scott M	SVP, Chief Financial Officer	A Award	2021-02-25	2021-03-01	33,000	—	$0	35,500	SEC↗
SCHADE CHRISTIAN S	Chairman & CEO	A Award	2021-02-25	2021-03-01	88,500	—	$0	176,660	SEC↗
SCHADE CHRISTIAN S	Chairman & CEO	A Award	2021-02-25	2021-03-01	77,000	—	$0	77,160	SEC↗
Abrahmsen Lars B.	SVP, Chief Scientific Office	A Award	2021-02-25	2021-03-01	19,000	—	$0	19,000	SEC↗
Wessels Gregory S.	SVP, Chief Commercial Office	A Award	2021-02-25	2021-03-01	16,000	—	$0	16,000	SEC↗
Attar Eyal C.	SVP, Chief Medical Officer	A Award	2021-02-25	2021-03-01	75,000	—	$0	108,000	SEC↗
Attar Eyal C.	SVP, Chief Medical Officer	A Award	2021-02-25	2021-03-01	33,000	—	$0	33,000	SEC↗
Redmile Group, LLC	10% Owner	S Sale	2020-12-28	2021-02-16	5,863	$5.80	$34.0K	1,768,718	SEC↗
Redmile Group, LLC	10% Owner	S Sale	2020-12-28	2021-02-16	494,137	$5.58	$2.76M	1,774,581	SEC↗
5AM Opportunities I (GP), LLC	Other	S Sale	2020-10-05	2020-10-07	175,000	$25.30	$4.43M	138,497	SEC↗
Kelly Michael Aaron	Director	A Award deriv	2020-09-28	2020-09-29	12,000	—	$0	12,000	SEC↗
Wessels Gregory S.	SVP, Chief Commercial Office	A Award deriv	2020-09-16	2020-09-18	14,700	—	$0	14,700	SEC↗
KCIF Co-Investment Fund KB	10% Owner	S Sale	2020-07-07	2020-07-07	241,703	$34.55	$8.35M	1,992,586	SEC↗
ROCKLAGE SCOTT M	Director	A Award deriv	2020-06-30	2020-07-01	5,600	—	$0	5,600	SEC↗
Christenson Johan	Director	A Award deriv	2020-06-30	2020-07-01	5,600	—	$0	5,600	SEC↗
Hepple Jonathan	Director	A Award deriv	2020-06-30	2020-07-01	5,600	—	$0	5,600	SEC↗
Seizinger Bernd R.	Director	A Award deriv	2020-06-30	2020-07-01	5,600	—	$0	5,600	SEC↗
HENNEMAN JOHN B III	Director	A Award deriv	2020-06-30	2020-07-01	5,600	—	$0	5,600	SEC↗
Peters Richard	Director	A Award deriv	2020-06-26	2020-06-29	7,000	—	$0	7,000	SEC↗
Namouni Fouad	Director	A Award deriv	2020-06-26	2020-06-29	7,000	—	$0	7,000	SEC↗
5AM Opportunities I (GP), LLC	10% Owner	S Sale	2020-06-16	2020-06-18	19,836	$33.30	$660.5K	313,497	SEC↗
5AM Opportunities I (GP), LLC	10% Owner	S Sale	2020-06-16	2020-06-18	4,807	$33.30	$160.1K	75,965	SEC↗
5AM Opportunities I (GP), LLC	10% Owner	S Sale	2020-06-16	2020-06-18	115,357	$33.30	$3.84M	1,823,192	SEC↗
ROCKLAGE SCOTT M	Director, 10% Owner	S Sale	2020-06-16	2020-06-18	4,807	$33.30	$160.1K	75,965	SEC↗
ROCKLAGE SCOTT M	Director, 10% Owner	S Sale	2020-06-16	2020-06-18	115,357	$33.30	$3.84M	1,823,192	SEC↗
5AM Partners IV, LLC	10% Owner	S Sale	2020-06-11	2020-06-15	9,800	$28.75	$281.8K	80,772	SEC↗
5AM Partners IV, LLC	10% Owner	S Sale	2020-06-11	2020-06-15	235,200	$28.75	$6.76M	1,938,549	SEC↗
ROCKLAGE SCOTT M	Director, 10% Owner	S Sale	2020-06-11	2020-06-15	9,800	$28.75	$281.8K	80,772	SEC↗
ROCKLAGE SCOTT M	Director, 10% Owner	S Sale	2020-06-11	2020-06-15	235,200	$28.75	$6.76M	1,938,549	SEC↗
5AM Partners IV, LLC	10% Owner	S Sale	2020-05-19	2020-05-21	10,200	$35.15	$358.5K	90,572	SEC↗
5AM Partners IV, LLC	10% Owner	S Sale	2020-05-19	2020-05-21	244,800	$35.15	$8.60M	2,173,748	SEC↗
ROCKLAGE SCOTT M	Director	S Sale	2020-05-19	2020-05-21	244,800	$35.15	$8.60M	2,173,748	SEC↗
ROCKLAGE SCOTT M	Director	S Sale	2020-05-19	2020-05-21	10,200	$35.15	$358.5K	90,572	SEC↗
Versant Vantage I GP, L.P.	10% Owner	J Other	2020-05-18	2020-05-20	1,750	—	$0	0	SEC↗
Versant Vantage I GP, L.P.	10% Owner	J Other	2020-05-18	2020-05-20	1,734	—	$0	0	SEC↗
Versant Vantage I GP, L.P.	10% Owner	J Other	2020-05-18	2020-05-20	116,664	—	$0	216,669	SEC↗
Versant Vantage I GP, L.P.	10% Owner	J Other	2020-05-18	2020-05-20	1,734	—	$0	1,734	SEC↗
Versant Vantage I GP, L.P.	10% Owner	J Other	2020-05-18	2020-05-20	1,750	—	$0	1,750	SEC↗
Versant Ophthalmic Affiliates	10% Owner	J Other	2020-05-18	2020-05-20	16,428	—	$0	0	SEC↗
Versant Ophthalmic Affiliates	10% Owner	J Other	2020-05-18	2020-05-20	16,428	—	$0	16,428	SEC↗
Versant Ophthalmic Affiliates	10% Owner	J Other	2020-05-18	2020-05-20	58,889	—	$0	109,374	SEC↗
Versant Ophthalmic Affiliates	10% Owner	J Other	2020-05-18	2020-05-20	25,794	—	$0	47,823	SEC↗
Versant Ophthalmic Affiliates	10% Owner	J Other	2020-05-18	2020-05-20	23,275	—	$0	43,231	SEC↗
Versant Ophthalmic Affiliates	10% Owner	J Other	2020-05-18	2020-05-20	773,805	—	$0	1,437,132	SEC↗
Versant Ophthalmic Affiliates	10% Owner	J Other	2020-05-18	2020-05-20	1,178	—	$0	0	SEC↗
Versant Ophthalmic Affiliates	10% Owner	J Other	2020-05-18	2020-05-20	1,178	—	$0	1,178	SEC↗
KDev Investments AB	10% Owner	S Sale	2020-04-13	2020-04-15	210,548	$31.25	$6.58M	2,234,289	SEC↗
Versant Ophthalmic Affiliates	10% Owner	J Other	2020-04-09	2020-05-20	168,263	—	$0	168,263	SEC↗
Versant Ophthalmic Affiliates	10% Owner	J Other	2020-04-09	2020-05-20	73,617	—	$0	73,617	SEC↗
Versant Ophthalmic Affiliates	10% Owner	J Other	2020-04-09	2020-05-20	66,506	—	$0	66,506	SEC↗
Versant Ophthalmic Affiliates	10% Owner	J Other	2020-04-09	2020-05-20	2,210,937	—	$0	2,210,937	SEC↗
Versant Ophthalmic Affiliates	10% Owner	J Other	2020-04-09	2020-05-20	2,519,323	—	$0	0	SEC↗
Coiante Scott M	SVP, Chief Financial Officer	A Award deriv	2020-03-24	2020-03-26	55,000	—	$0	55,000	SEC↗
Abrahmsen Lars B.	SVP, Chief Scientific Office	A Award deriv	2020-03-24	2020-03-26	31,600	—	$0	31,600	SEC↗
Attar Eyal C.	SVP, Chief Medical Officer	A Award deriv	2020-03-24	2020-03-26	55,000	—	$0	55,000	SEC↗
Korbel Gregory Alan	VP of Business Dev't	A Award deriv	2020-03-24	2020-03-26	12,800	—	$0	12,800	SEC↗
SCHADE CHRISTIAN S	President & CEO	A Award deriv	2020-03-24	2020-03-26	127,000	—	$0	127,000	SEC↗
SCHADE CHRISTIAN S	President & CEO	A Award deriv	2019-10-07	2019-10-07	306,085	—	$0	306,085	SEC↗
Coiante Scott M	SVP, Chief Financial Officer	A Award deriv	2019-10-07	2019-10-07	150,824	—	$0	150,824	SEC↗
Attar Eyal C.	SVP, Chief Medical Officer	A Award deriv	2019-10-07	2019-10-07	77,630	—	$0	77,630	SEC↗
Abrahmsen Lars B.	SVP, Chief Scientific Office	A Award deriv	2019-10-07	2019-10-07	77,630	—	$0	77,630	SEC↗
Korbel Gregory Alan	VP of Business Dev't	A Award deriv	2019-10-07	2019-10-07	64,322	—	$0	64,322	SEC↗
HENNEMAN JOHN B III	Director	A Award deriv	2019-10-07	2019-10-07	18,407	—	$0	18,407	SEC↗
ROCKLAGE SCOTT M	Director	C Conversion deriv	2019-10-07	2019-10-07	492,475	—	$0	0	SEC↗
ROCKLAGE SCOTT M	Director	C Conversion deriv	2019-10-07	2019-10-07	79,746	—	$0	0	SEC↗
ROCKLAGE SCOTT M	Director	C Conversion deriv	2019-10-07	2019-10-07	1,913,910	—	$0	0	SEC↗
ROCKLAGE SCOTT M	Director	C Conversion deriv	2019-10-07	2019-10-07	20,519	—	$0	0	SEC↗
KDev Investments AB	10% Owner	C Conversion deriv	2019-10-07	2019-10-07	579,647	—	$0	0	SEC↗
KDev Investments AB	10% Owner	C Conversion deriv	2019-10-07	2019-10-07	590,445	—	$0	0	SEC↗
KDev Investments AB	10% Owner	C Conversion deriv	2019-10-07	2019-10-07	430,467	—	$0	0	SEC↗
Seizinger Bernd R.	Director	M Exercise deriv	2019-10-07	2019-10-07	263,970	—	$0	0	SEC↗
Christenson Johan	Director	C Conversion deriv	2019-10-07	2019-10-07	1,661,382	—	$0	0	SEC↗
Christenson Johan	Director	C Conversion deriv	2019-10-07	2019-10-07	427,496	—	$0	0	SEC↗
Versant Ventures V GP-GP (Cana	10% Owner	C Conversion deriv	2019-10-07	2019-10-07	512,995	—	$0	0	SEC↗
Versant Ventures V GP-GP (Cana	10% Owner	C Conversion deriv	2019-10-07	2019-10-07	1,993,658	—	$0	0	SEC↗
Versant Vantage I GP-GP, LLC	10% Owner	C Conversion deriv	2019-10-07	2019-10-07	1,993,658	—	$0	0	SEC↗
Versant Vantage I GP-GP, LLC	10% Owner	C Conversion deriv	2019-10-07	2019-10-07	512,995	—	$0	0	SEC↗
HealthCap VII, L.P.	10% Owner	C Conversion deriv	2019-10-07	2019-10-07	1,661,382	—	$0	0	SEC↗
HealthCap VII, L.P.	10% Owner	C Conversion deriv	2019-10-07	2019-10-07	427,496	—	$0	0	SEC↗
Redmile Group, LLC	10% Owner	C Conversion deriv	2019-10-07	2019-10-08	1,164,674	—	$0	0	SEC↗
5AM Ventures IV, L.P.	10% Owner	C Conversion deriv	2019-10-07	2019-10-09	20,519	—	$0	0	SEC↗
5AM Ventures IV, L.P.	10% Owner	C Conversion deriv	2019-10-07	2019-10-09	492,475	—	$0	0	SEC↗
5AM Ventures IV, L.P.	10% Owner	C Conversion deriv	2019-10-07	2019-10-09	79,746	—	$0	0	SEC↗
5AM Ventures IV, L.P.	10% Owner	C Conversion deriv	2019-10-07	2019-10-09	1,913,910	—	$0	0	SEC↗
SCHADE CHRISTIAN S	President & CEO	P Buy	2019-10-07	2019-10-07	1,000	$15.00	$15.0K	1,000	SEC↗
SCHADE CHRISTIAN S	President & CEO	P Buy	2019-10-07	2019-10-07	1,000	$15.00	$15.0K	1,000	SEC↗
SCHADE CHRISTIAN S	President & CEO	P Buy	2019-10-07	2019-10-07	1,000	$15.00	$15.0K	1,000	SEC↗
SCHADE CHRISTIAN S	President & CEO	P Buy	2019-10-07	2019-10-07	1,000	$15.00	$15.0K	1,000	SEC↗