Open-mkt buys · 90d
—
0 trades · 0 insiders
Open-mkt sales · 90d
—
0 trades · 0 insiders
Net · 90d
$0
Insiders on file
32
Daily buy vs sell · 90 days
No data yet.
Insiders
| Insider | Role | Trades | Bought | Sold | Last trade |
|---|---|---|---|---|---|
| Keese Kari Leigh | Chief Financial Officer | 8 | $0 | $441.9K | 2024-11-15 |
| Lopez Esteban | Director | 7 | $0 | $134.8K | 2024-11-15 |
| Woock John | EVP, Chief Mktg/Strtgy Officer | 102 | $0 | $12.55M | 2024-11-15 |
| Sama Rinda | Chief Operating Officer | 138 | $0 | $20.44M | 2024-11-15 |
| Noblett Karen | Chief Medical Officer | 44 | $0 | $7.04M | 2024-11-15 |
| snyderman nancy lynn MD | Director | 13 | $74.2K | $0 | 2024-11-15 |
| Demski David M | Director | 7 | $0 | $0 | 2024-11-15 |
| McNamara Robert | Director | 7 | $0 | $0 | 2024-11-15 |
| Kiernan Jane E | Director | 17 | $0 | $742.4K | 2024-11-15 |
| Ford Alfred J Jr | Chief Commercial Officer | 72 | $0 | $10.51M | 2024-11-15 |
| COHEN RAYMOND W | Chief Executive Officer | 92 | $106.4K | $36.86M | 2024-11-15 |
| CARREL MICHAEL H | Director | 12 | $0 | $0 | 2024-11-15 |
| Dearen Danny L. | See Remarks | 189 | $0 | $35.23M | 2023-09-29 |
| MCNAMARA ROBERT E | Director | 9 | $0 | $475.1K | 2021-01-13 |
| Tammenoms Bakker Juliet | Director, 10% Owner | 16 | $8.00M | $494.6K | 2020-09-18 |
| Amble Erik | Director | 16 | $0 | $0 | 2020-08-24 |
| BioDiscovery 4 FCPR | 10% Owner | 3 | $0 | $15.68M | 2020-01-22 |
| Wisniewski Raphael | Director, 10% Owner | 12 | $13.00M | $15.68M | 2020-01-22 |
| Williamson Michael V. | See Remarks | 6 | $0 | $394.0K | 2019-07-02 |
| Pardo Geoff | Director, 10% Owner | 9 | $13.00M | $64.6K | 2019-06-28 |
| MATHUR PRABODH | See Remarks | 3 | $0 | $0 | 2019-01-30 |
| Jiang Guangqiang | Chief Technology Officer | 5 | $0 | $0 | 2019-01-30 |
| Petrovich John George | Director | 6 | $0 | $0 | 2018-12-06 |
| Malik Shahzad | Director | 10 | $0 | $0 | 2018-12-06 |
| Gilde Healthcare IV Management B.V. | 10% Owner | 3 | $13.00M | $0 | 2018-11-02 |
| Zac & Cloud Holdings LTD | Other | 6 | $0 | $0 | 2018-11-02 |
| Andera Partners | 10% Owner | 9 | $13.00M | $0 | 2018-11-02 |
| Alfred E. Mann Foundation for Scientific Research | Other | 4 | $0 | $0 | 2018-11-02 |
| NeoMed Innovation V L.P. | Other | 8 | $0 | $0 | 2018-11-02 |
| Advent Life Sciences LLP | Other | 8 | $0 | $0 | 2018-11-02 |
| ENRIGHT PATRICK G | 10% Owner | 3 | $8.00M | $0 | 2018-11-02 |
| Cormorant Global Healthcare GP, LLC | 10% Owner | 5 | $2.00M | $0 | 2018-10-31 |
Trade history
| Insider | Role | Code | Trade | Filed | Shares | Price | Value | Owned after | |
|---|---|---|---|---|---|---|---|---|---|
| CARREL MICHAEL H | Director | D To issuer deriv | 2024-11-15 | 2024-11-15 | 10,000 | $50.15 | $501.5K | 0 | SEC↗ |
| CARREL MICHAEL H | Director | D To issuer deriv | 2024-11-15 | 2024-11-15 | 5,000 | $36.90 | $184.5K | 0 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | D To issuer deriv | 2024-11-15 | 2024-11-15 | 106,776 | $69.37 | $7.41M | 0 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | D To issuer deriv | 2024-11-15 | 2024-11-15 | 31,125 | — | $0 | 0 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | D To issuer deriv | 2024-11-15 | 2024-11-15 | 196,451 | $56.81 | $11.16M | 0 | SEC↗ |
| Demski David M | Director | D To issuer deriv | 2024-11-15 | 2024-11-15 | 10,000 | $19.30 | $193.0K | 0 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | D To issuer deriv | 2024-11-15 | 2024-11-15 | 4,655 | $45.18 | $210.3K | 0 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | D To issuer deriv | 2024-11-15 | 2024-11-15 | 11,250 | — | $0 | 0 | SEC↗ |
| Keese Kari Leigh | Chief Financial Officer | D To issuer deriv | 2024-11-15 | 2024-11-15 | 3,125 | — | $0 | 0 | SEC↗ |
| Lopez Esteban | Director | D To issuer deriv | 2024-11-15 | 2024-11-15 | 10,000 | $11.30 | $113.0K | 0 | SEC↗ |
| McNamara Robert | Director | D To issuer deriv | 2024-11-15 | 2024-11-15 | 5,000 | $56.20 | $281.0K | 0 | SEC↗ |
| McNamara Robert | Director | D To issuer deriv | 2024-11-15 | 2024-11-15 | 10,000 | $36.90 | $369.0K | 0 | SEC↗ |
| McNamara Robert | Director | D To issuer deriv | 2024-11-15 | 2024-11-15 | 3,333 | $33.85 | $112.8K | 0 | SEC↗ |
| Noblett Karen | Chief Medical Officer | D To issuer deriv | 2024-11-15 | 2024-11-15 | 11,998 | $69.37 | $832.3K | 0 | SEC↗ |
| Noblett Karen | Chief Medical Officer | D To issuer deriv | 2024-11-15 | 2024-11-15 | 2,963 | $56.81 | $168.3K | 0 | SEC↗ |
| Noblett Karen | Chief Medical Officer | D To issuer deriv | 2024-11-15 | 2024-11-15 | 7,500 | — | $0 | 0 | SEC↗ |
| Noblett Karen | Chief Medical Officer | D To issuer deriv | 2024-11-15 | 2024-11-15 | 6,348 | $45.18 | $286.8K | 0 | SEC↗ |
| Sama Rinda | Chief Operating Officer | D To issuer deriv | 2024-11-15 | 2024-11-15 | 13,125 | — | $0 | 0 | SEC↗ |
| Sama Rinda | Chief Operating Officer | D To issuer deriv | 2024-11-15 | 2024-11-15 | 11,019 | $56.81 | $626.0K | 0 | SEC↗ |
| Sama Rinda | Chief Operating Officer | D To issuer deriv | 2024-11-15 | 2024-11-15 | 6,294 | $69.37 | $436.6K | 0 | SEC↗ |
| Sama Rinda | Chief Operating Officer | D To issuer deriv | 2024-11-15 | 2024-11-15 | 9,962 | $45.18 | $450.1K | 0 | SEC↗ |
| snyderman nancy lynn MD | Director | D To issuer deriv | 2024-11-15 | 2024-11-15 | 10,000 | $49.96 | $499.6K | 0 | SEC↗ |
| snyderman nancy lynn MD | Director | D To issuer deriv | 2024-11-15 | 2024-11-15 | 4,167 | $36.90 | $153.8K | 0 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | D To issuer deriv | 2024-11-15 | 2024-11-15 | 13,125 | — | $0 | 0 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | D To issuer deriv | 2024-11-15 | 2024-11-15 | 15,555 | $56.81 | $883.7K | 0 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | D To issuer deriv | 2024-11-15 | 2024-11-15 | 3,581 | $45.18 | $161.8K | 0 | SEC↗ |
| CARREL MICHAEL H | Director | D To issuer | 2024-11-15 | 2024-11-15 | 17,861 | $71.00 | $1.27M | 0 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | D To issuer | 2024-11-15 | 2024-11-15 | 292,731 | $71.00 | $20.78M | 0 | SEC↗ |
| Demski David M | Director | D To issuer | 2024-11-15 | 2024-11-15 | 9,542 | $71.00 | $677.5K | 0 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | D To issuer | 2024-11-15 | 2024-11-15 | 43,450 | $71.00 | $3.08M | 0 | SEC↗ |
| Keese Kari Leigh | Chief Financial Officer | D To issuer | 2024-11-15 | 2024-11-15 | 40,362 | $71.00 | $2.87M | 0 | SEC↗ |
| Lopez Esteban | Director | D To issuer | 2024-11-15 | 2024-11-15 | 6,600 | $71.00 | $468.6K | 0 | SEC↗ |
| McNamara Robert | Director | D To issuer | 2024-11-15 | 2024-11-15 | 14,861 | $71.00 | $1.06M | 0 | SEC↗ |
| Noblett Karen | Chief Medical Officer | D To issuer | 2024-11-15 | 2024-11-15 | 34,428 | $71.00 | $2.44M | 0 | SEC↗ |
| Sama Rinda | Chief Operating Officer | D To issuer | 2024-11-15 | 2024-11-15 | 83,854 | $71.00 | $5.95M | 0 | SEC↗ |
| Sama Rinda | Chief Operating Officer | D To issuer | 2024-11-15 | 2024-11-15 | 608 | $71.00 | $43.2K | 0 | SEC↗ |
| snyderman nancy lynn MD | Director | D To issuer | 2024-11-15 | 2024-11-15 | 14,944 | $71.00 | $1.06M | 0 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | D To issuer | 2024-11-15 | 2024-11-15 | 77,403 | $71.00 | $5.50M | 0 | SEC↗ |
| Kiernan Jane E | Director | D To issuer | 2024-11-15 | 2024-11-15 | 19,861 | $71.00 | $1.41M | 0 | SEC↗ |
| snyderman nancy lynn MD | Director | G Gift | 2024-11-07 | 2024-11-12 | 5,000 | — | $0 | 14,944 | SEC↗ |
| Keese Kari Leigh | Chief Financial Officer | S Sale | 2024-10-02 | 2024-10-03 | 364 | $69.40 | $25.3K | 42,959 | SEC↗ |
| Keese Kari Leigh | Chief Financial Officer | S Sale | 2024-10-02 | 2024-10-03 | 2,597 | $69.41 | $180.3K | 40,362 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | M Exercise deriv | 2024-07-24 | 2024-07-25 | 78,125 | — | $0 | 0 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | M Exercise deriv | 2024-07-24 | 2024-07-25 | 25,771 | — | $0 | 196,451 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | M Exercise | 2024-07-24 | 2024-07-25 | 25,771 | $14.19 | $365.7K | 214,606 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | M Exercise | 2024-07-24 | 2024-07-25 | 78,125 | $25.82 | $2.02M | 292,731 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | M Exercise deriv | 2024-01-31 | 2024-02-02 | 41,500 | — | $0 | 0 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | M Exercise deriv | 2024-01-31 | 2024-02-02 | 21,900 | — | $0 | 0 | SEC↗ |
| Keese Kari Leigh | Chief Financial Officer | M Exercise deriv | 2024-01-31 | 2024-02-02 | 2,000 | — | $0 | 0 | SEC↗ |
| Keese Kari Leigh | Chief Financial Officer | M Exercise deriv | 2024-01-31 | 2024-02-02 | 4,167 | — | $0 | 0 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | M Exercise deriv | 2024-01-31 | 2024-02-02 | 10,500 | — | $0 | 0 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | M Exercise deriv | 2024-01-31 | 2024-02-02 | 15,000 | — | $0 | 0 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | M Exercise deriv | 2024-01-31 | 2024-02-02 | 17,500 | — | $0 | 0 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | M Exercise deriv | 2024-01-31 | 2024-02-02 | 10,500 | — | $0 | 0 | SEC↗ |
| Noblett Karen | Chief Medical Officer | M Exercise deriv | 2024-01-31 | 2024-02-02 | 6,500 | — | $0 | 0 | SEC↗ |
| Noblett Karen | Chief Medical Officer | M Exercise deriv | 2024-01-31 | 2024-02-02 | 15,000 | — | $0 | 0 | SEC↗ |
| Sama Rinda | Chief Operating Officer | M Exercise deriv | 2024-01-31 | 2024-02-02 | 10,500 | — | $0 | 0 | SEC↗ |
| Sama Rinda | Chief Operating Officer | M Exercise deriv | 2024-01-31 | 2024-02-02 | 17,500 | — | $0 | 0 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | S Sale | 2024-01-31 | 2024-02-02 | 35,161 | $67.74 | $2.38M | 188,835 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | M Exercise | 2024-01-31 | 2024-02-02 | 63,400 | — | $0 | 223,996 | SEC↗ |
| Keese Kari Leigh | Chief Financial Officer | S Sale | 2024-01-31 | 2024-02-02 | 3,489 | $67.74 | $236.3K | 43,323 | SEC↗ |
| Keese Kari Leigh | Chief Financial Officer | M Exercise | 2024-01-31 | 2024-02-02 | 6,167 | — | $0 | 46,812 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | M Exercise | 2024-01-31 | 2024-02-02 | 25,500 | — | $0 | 60,065 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | S Sale | 2024-01-31 | 2024-02-02 | 16,615 | $67.74 | $1.13M | 43,450 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | M Exercise | 2024-01-31 | 2024-02-02 | 28,000 | — | $0 | 93,302 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | S Sale | 2024-01-31 | 2024-02-02 | 15,899 | $67.74 | $1.08M | 77,403 | SEC↗ |
| Noblett Karen | Chief Medical Officer | M Exercise | 2024-01-31 | 2024-02-02 | 27,500 | — | $0 | 45,716 | SEC↗ |
| Noblett Karen | Chief Medical Officer | S Sale | 2024-01-31 | 2024-02-02 | 11,288 | $67.74 | $764.6K | 34,428 | SEC↗ |
| Sama Rinda | Chief Operating Officer | M Exercise | 2024-01-31 | 2024-02-02 | 28,000 | — | $0 | 83,854 | SEC↗ |
| Noblett Karen | Chief Medical Officer | S Sale | 2024-01-08 | 2024-01-10 | 15,999 | $69.00 | $1.10M | 18,216 | SEC↗ |
| Noblett Karen | Chief Medical Officer | S Sale | 2023-12-28 | 2023-12-28 | 7,051 | $63.28 | $446.2K | 34,215 | SEC↗ |
| Noblett Karen | Chief Medical Officer | S Sale | 2023-12-26 | 2023-12-28 | 949 | $63.00 | $59.8K | 41,266 | SEC↗ |
| Dearen Danny L. | President & CFO | M Exercise deriv | 2023-09-29 | 2023-10-03 | 11,250 | — | $0 | 0 | SEC↗ |
| Dearen Danny L. | President & CFO | S Sale | 2023-09-29 | 2023-10-03 | 7,675 | $56.87 | $436.5K | 23,777 | SEC↗ |
| Dearen Danny L. | President & CFO | M Exercise | 2023-09-29 | 2023-10-03 | 11,250 | — | $0 | 31,452 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | S Sale | 2023-08-15 | 2023-08-17 | 14,769 | $62.34 | $920.7K | 34,565 | SEC↗ |
| CARREL MICHAEL H | Director | G Gift | 2023-08-08 | 2023-08-08 | 500 | — | $0 | 17,861 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | S Sale | 2023-07-28 | 2023-08-01 | 1,500 | $62.01 | $93.0K | 49,334 | SEC↗ |
| McNamara Robert | Director | A Award | 2023-06-26 | 2023-06-28 | 3,000 | — | $0 | 14,861 | SEC↗ |
| CARREL MICHAEL H | Director | A Award | 2023-06-26 | 2023-06-28 | 3,000 | — | $0 | 18,361 | SEC↗ |
| snyderman nancy lynn MD | Director | A Award | 2023-06-26 | 2023-06-28 | 3,000 | — | $0 | 19,944 | SEC↗ |
| Kiernan Jane E | Director | A Award | 2023-06-26 | 2023-06-28 | 3,000 | — | $0 | 19,861 | SEC↗ |
| Demski David M | Director | A Award | 2023-06-26 | 2023-06-28 | 3,000 | — | $0 | 9,542 | SEC↗ |
| Lopez Esteban | Director | A Award | 2023-06-26 | 2023-06-28 | 3,000 | — | $0 | 6,600 | SEC↗ |
| Dearen Danny L. | President & CFO | S Sale | 2023-05-26 | 2023-05-31 | 300 | $50.14 | $15.0K | 9,202 | SEC↗ |
| Dearen Danny L. | President & CFO | S Sale | 2023-05-26 | 2023-05-31 | 7,699 | $49.44 | $380.6K | 9,502 | SEC↗ |
| Dearen Danny L. | President & CFO | M Exercise deriv | 2023-04-21 | 2023-04-25 | 13,208 | — | $0 | 0 | SEC↗ |
| Dearen Danny L. | President & CFO | S Sale | 2023-04-21 | 2023-04-25 | 10,363 | $59.93 | $621.1K | 26,838 | SEC↗ |
| Dearen Danny L. | President & CFO | M Exercise | 2023-04-21 | 2023-04-25 | 13,208 | $14.19 | $187.4K | 37,201 | SEC↗ |
| Dearen Danny L. | President & CFO | S Sale | 2023-04-21 | 2023-04-25 | 9,637 | $60.50 | $583.0K | 17,201 | SEC↗ |
| Dearen Danny L. | President & CFO | M Exercise deriv | 2023-04-20 | 2023-04-24 | 2,001 | — | $0 | 13,208 | SEC↗ |
| Dearen Danny L. | President & CFO | S Sale | 2023-04-20 | 2023-04-24 | 2,001 | $60.01 | $120.1K | 23,993 | SEC↗ |
| Dearen Danny L. | President & CFO | M Exercise | 2023-04-20 | 2023-04-24 | 2,001 | $14.19 | $28.4K | 25,994 | SEC↗ |
| Dearen Danny L. | President & CFO | M Exercise deriv | 2023-03-31 | 2023-04-04 | 5,468 | — | $0 | 7,032 | SEC↗ |
| Dearen Danny L. | President & CFO | M Exercise deriv | 2023-03-31 | 2023-04-04 | 2,899 | — | $0 | 0 | SEC↗ |
| Dearen Danny L. | President & CFO | M Exercise deriv | 2023-03-31 | 2023-04-04 | 6,633 | — | $0 | 15,209 | SEC↗ |
| Dearen Danny L. | President & CFO | S Sale | 2023-03-31 | 2023-04-04 | 7,802 | $55.68 | $434.4K | 23,993 | SEC↗ |
| Dearen Danny L. | President & CFO | S Sale | 2023-03-31 | 2023-04-04 | 7,198 | $54.83 | $394.7K | 31,795 | SEC↗ |
| Dearen Danny L. | President & CFO | M Exercise | 2023-03-31 | 2023-04-04 | 2,899 | $1.63 | $4.7K | 38,993 | SEC↗ |
| Dearen Danny L. | President & CFO | M Exercise | 2023-03-31 | 2023-04-04 | 6,633 | $14.19 | $94.1K | 30,626 | SEC↗ |
| Dearen Danny L. | President & CFO | M Exercise | 2023-03-31 | 2023-04-04 | 5,468 | $25.82 | $141.2K | 36,094 | SEC↗ |
| Sama Rinda | Chief Operating Officer | S Sale | 2023-02-21 | 2023-02-23 | 16,229 | $56.18 | $911.7K | 59,554 | SEC↗ |
| Sama Rinda | Chief Operating Officer | S Sale | 2023-02-21 | 2023-02-23 | 3,392 | $56.53 | $191.7K | 608 | SEC↗ |
| Sama Rinda | Chief Operating Officer | S Sale | 2023-02-21 | 2023-02-23 | 3,700 | $56.69 | $209.8K | 55,854 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | S Sale | 2023-02-01 | 2023-02-02 | 581 | $60.43 | $35.1K | 68,700 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | S Sale | 2023-02-01 | 2023-02-02 | 3,398 | $61.02 | $207.3K | 65,302 | SEC↗ |
| Noblett Karen | Chief Medical Officer | S Sale | 2023-02-01 | 2023-02-02 | 795 | $61.02 | $48.5K | 42,215 | SEC↗ |
| Noblett Karen | Chief Medical Officer | S Sale | 2023-02-01 | 2023-02-02 | 136 | $60.43 | $8.2K | 43,010 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | S Sale | 2023-02-01 | 2023-02-02 | 1,185 | $60.43 | $71.6K | 167,528 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | S Sale | 2023-02-01 | 2023-02-02 | 6,932 | $61.02 | $423.0K | 160,596 | SEC↗ |
| Dearen Danny L. | President & CFO | S Sale | 2023-02-01 | 2023-02-02 | 474 | $60.43 | $28.6K | 26,765 | SEC↗ |
| Dearen Danny L. | President & CFO | S Sale | 2023-02-01 | 2023-02-02 | 2,772 | $61.02 | $169.1K | 23,993 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | S Sale | 2023-02-01 | 2023-02-02 | 3,164 | $61.02 | $193.1K | 50,834 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | S Sale | 2023-02-01 | 2023-02-02 | 541 | $60.43 | $32.7K | 53,998 | SEC↗ |
| Sama Rinda | Chief Operating Officer | S Sale | 2023-02-01 | 2023-02-02 | 4,334 | $61.02 | $264.5K | 75,783 | SEC↗ |
| Sama Rinda | Chief Operating Officer | S Sale | 2023-02-01 | 2023-02-02 | 741 | $60.43 | $44.8K | 80,117 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | A Award deriv | 2023-01-31 | 2023-02-02 | 17,500 | — | $0 | 17,500 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | M Exercise deriv | 2023-01-31 | 2023-02-02 | 11,250 | — | $0 | 0 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | M Exercise deriv | 2023-01-31 | 2023-02-02 | 10,875 | — | $0 | 0 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | A Award deriv | 2023-01-31 | 2023-02-02 | 8,750 | — | $0 | 8,750 | SEC↗ |
| Noblett Karen | Chief Medical Officer | M Exercise deriv | 2023-01-31 | 2023-02-02 | 4,250 | — | $0 | 0 | SEC↗ |
| Noblett Karen | Chief Medical Officer | A Award deriv | 2023-01-31 | 2023-02-02 | 5,000 | — | $0 | 5,000 | SEC↗ |
| Noblett Karen | Chief Medical Officer | A Award deriv | 2023-01-31 | 2023-02-02 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Noblett Karen | Chief Medical Officer | M Exercise deriv | 2023-01-31 | 2023-02-02 | 6,000 | — | $0 | 0 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | A Award deriv | 2023-01-31 | 2023-02-02 | 41,500 | — | $0 | 41,500 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | A Award deriv | 2023-01-31 | 2023-02-02 | 20,750 | — | $0 | 20,750 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | M Exercise deriv | 2023-01-31 | 2023-02-02 | 40,000 | — | $0 | 0 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | M Exercise deriv | 2023-01-31 | 2023-02-02 | 21,968 | — | $0 | 0 | SEC↗ |
| Dearen Danny L. | President & CFO | M Exercise deriv | 2023-01-31 | 2023-02-02 | 5,250 | — | $0 | 0 | SEC↗ |
| Dearen Danny L. | President & CFO | M Exercise deriv | 2023-01-31 | 2023-02-02 | 20,000 | — | $0 | 0 | SEC↗ |
| Dearen Danny L. | President & CFO | A Award deriv | 2023-01-31 | 2023-02-02 | 5,000 | — | $0 | 5,000 | SEC↗ |
| Dearen Danny L. | President & CFO | A Award deriv | 2023-01-31 | 2023-02-02 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | A Award deriv | 2023-01-31 | 2023-02-02 | 7,500 | — | $0 | 7,500 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | M Exercise deriv | 2023-01-31 | 2023-02-02 | 5,250 | — | $0 | 0 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | A Award deriv | 2023-01-31 | 2023-02-02 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | M Exercise deriv | 2023-01-31 | 2023-02-02 | 11,250 | — | $0 | 0 | SEC↗ |
| Sama Rinda | Chief Operating Officer | A Award deriv | 2023-01-31 | 2023-02-02 | 17,500 | — | $0 | 17,500 | SEC↗ |
| Sama Rinda | Chief Operating Officer | A Award deriv | 2023-01-31 | 2023-02-02 | 8,750 | — | $0 | 8,750 | SEC↗ |
| Sama Rinda | Chief Operating Officer | M Exercise deriv | 2023-01-31 | 2023-02-02 | 20,000 | — | $0 | 0 | SEC↗ |
| Sama Rinda | Chief Operating Officer | M Exercise deriv | 2023-01-31 | 2023-02-02 | 10,875 | — | $0 | 0 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | M Exercise | 2023-01-31 | 2023-02-02 | 22,125 | — | $0 | 76,851 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | A Award | 2023-01-31 | 2023-02-02 | 8,750 | — | $0 | 54,726 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | S Sale | 2023-01-31 | 2023-02-02 | 3,389 | $61.17 | $207.3K | 73,462 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | S Sale | 2023-01-31 | 2023-02-02 | 4,181 | $61.12 | $255.5K | 69,281 | SEC↗ |
| Noblett Karen | Chief Medical Officer | A Award | 2023-01-31 | 2023-02-02 | 5,000 | — | $0 | 36,599 | SEC↗ |
| Noblett Karen | Chief Medical Officer | M Exercise | 2023-01-31 | 2023-02-02 | 10,250 | — | $0 | 46,849 | SEC↗ |
| Noblett Karen | Chief Medical Officer | S Sale | 2023-01-31 | 2023-02-02 | 2,167 | $61.17 | $132.6K | 44,682 | SEC↗ |
| Noblett Karen | Chief Medical Officer | S Sale | 2023-01-31 | 2023-02-02 | 1,536 | $61.12 | $93.9K | 43,146 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | S Sale | 2023-01-31 | 2023-02-02 | 9,032 | $61.12 | $552.0K | 168,713 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | A Award | 2023-01-31 | 2023-02-02 | 20,750 | — | $0 | 129,649 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | M Exercise | 2023-01-31 | 2023-02-02 | 61,968 | — | $0 | 191,617 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | S Sale | 2023-01-31 | 2023-02-02 | 13,872 | $61.17 | $848.6K | 177,745 | SEC↗ |
| Dearen Danny L. | President & CFO | S Sale | 2023-01-31 | 2023-02-02 | 2,720 | $61.12 | $166.2K | 27,239 | SEC↗ |
| Dearen Danny L. | President & CFO | S Sale | 2023-01-31 | 2023-02-02 | 7,791 | $61.17 | $476.6K | 29,959 | SEC↗ |
| Dearen Danny L. | President & CFO | M Exercise | 2023-01-31 | 2023-02-02 | 25,250 | — | $0 | 37,750 | SEC↗ |
| Dearen Danny L. | President & CFO | A Award | 2023-01-31 | 2023-02-02 | 5,000 | — | $0 | 12,500 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | S Sale | 2023-01-31 | 2023-02-02 | 1,999 | $61.12 | $122.2K | 54,539 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | S Sale | 2023-01-31 | 2023-02-02 | 4,235 | $61.17 | $259.1K | 56,538 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | M Exercise | 2023-01-31 | 2023-02-02 | 16,500 | — | $0 | 60,773 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | A Award | 2023-01-31 | 2023-02-02 | 7,500 | — | $0 | 44,273 | SEC↗ |
| Sama Rinda | Chief Operating Officer | S Sale | 2023-01-31 | 2023-02-02 | 5,634 | $61.12 | $344.4K | 80,858 | SEC↗ |
| Sama Rinda | Chief Operating Officer | S Sale | 2023-01-31 | 2023-02-02 | 7,791 | $61.17 | $476.6K | 86,492 | SEC↗ |
| Sama Rinda | Chief Operating Officer | M Exercise | 2023-01-31 | 2023-02-02 | 30,875 | — | $0 | 94,283 | SEC↗ |
| Sama Rinda | Chief Operating Officer | A Award | 2023-01-31 | 2023-02-02 | 8,750 | — | $0 | 63,408 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | M Exercise deriv | 2023-01-17 | 2023-01-19 | 378 | — | $0 | 0 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | M Exercise deriv | 2023-01-17 | 2023-01-19 | 2,793 | — | $0 | 0 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | M Exercise deriv | 2023-01-17 | 2023-01-19 | 15,000 | — | $0 | 15,555 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | M Exercise deriv | 2023-01-17 | 2023-01-19 | 12,044 | — | $0 | 3,581 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | M Exercise | 2023-01-17 | 2023-01-19 | 378 | $1.42 | $537 | 46,354 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | S Sale | 2023-01-17 | 2023-01-19 | 2,793 | $67.62 | $188.9K | 45,976 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | M Exercise | 2023-01-17 | 2023-01-19 | 2,793 | $1.32 | $3.7K | 48,769 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | S Sale | 2023-01-17 | 2023-01-19 | 12,044 | $67.32 | $810.8K | 45,976 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | M Exercise | 2023-01-17 | 2023-01-19 | 12,044 | $25.82 | $311.0K | 58,020 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | S Sale | 2023-01-17 | 2023-01-19 | 15,000 | $67.29 | $1.01M | 45,976 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | M Exercise | 2023-01-17 | 2023-01-19 | 15,000 | $14.19 | $212.8K | 60,976 | SEC↗ |
| Woock John | EVP, Chief Mktg/Strtgy Offic | S Sale | 2023-01-17 | 2023-01-19 | 378 | $67.51 | $25.5K | 45,976 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | M Exercise deriv | 2023-01-13 | 2023-01-18 | 8,509 | — | $0 | 0 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | M Exercise deriv | 2023-01-13 | 2023-01-18 | 1,899 | — | $0 | 0 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | M Exercise deriv | 2023-01-13 | 2023-01-18 | 16,297 | — | $0 | 0 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | M Exercise deriv | 2023-01-13 | 2023-01-18 | 9,310 | — | $0 | 4,655 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | S Sale | 2023-01-13 | 2023-01-18 | 15,292 | $65.90 | $1.01M | 57,496 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | M Exercise | 2023-01-13 | 2023-01-18 | 8,509 | $1.42 | $12.1K | 45,282 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | M Exercise | 2023-01-13 | 2023-01-18 | 1,899 | $1.63 | $3.1K | 47,181 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | S Sale | 2023-01-13 | 2023-01-18 | 3,615 | $67.18 | $242.9K | 36,773 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | S Sale | 2023-01-13 | 2023-01-18 | 17,108 | $66.69 | $1.14M | 40,388 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | M Exercise | 2023-01-13 | 2023-01-18 | 16,297 | $14.19 | $231.3K | 72,788 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | M Exercise | 2023-01-13 | 2023-01-18 | 9,310 | $25.82 | $240.4K | 56,491 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | S Sale | 2023-01-13 | 2023-01-18 | 22,052 | $66.27 | $1.46M | 108,899 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | S Sale | 2023-01-13 | 2023-01-18 | 18,684 | $65.54 | $1.22M | 130,951 | SEC↗ |
| Lopez Esteban | Director | S Sale | 2022-12-13 | 2022-12-15 | 2,000 | $67.42 | $134.8K | 3,600 | SEC↗ |
| Dearen Danny L. | See Remarks | S Sale | 2022-09-13 | 2022-09-15 | 656 | $75.60 | $49.6K | 7,500 | SEC↗ |
| Noblett Karen | Chief Medical Officer | M Exercise deriv | 2022-09-12 | 2022-09-20 | 13,964 | — | $0 | 6,348 | SEC↗ |
| Noblett Karen | Chief Medical Officer | M Exercise deriv | 2022-09-12 | 2022-09-20 | 18,519 | — | $0 | 2,963 | SEC↗ |
| Noblett Karen | Chief Medical Officer | S Sale | 2022-09-12 | 2022-09-20 | 32,483 | $78.16 | $2.54M | 31,599 | SEC↗ |
| Noblett Karen | Chief Medical Officer | M Exercise | 2022-09-12 | 2022-09-20 | 13,964 | $25.82 | $360.6K | 64,082 | SEC↗ |
| Noblett Karen | Chief Medical Officer | M Exercise | 2022-09-12 | 2022-09-20 | 18,519 | $14.19 | $262.8K | 50,118 | SEC↗ |
| Woock John | Chief Marketing Officer | M Exercise deriv | 2022-09-08 | 2022-09-12 | 3,800 | — | $0 | 378 | SEC↗ |
| Woock John | Chief Marketing Officer | M Exercise deriv | 2022-09-08 | 2022-09-12 | 3,700 | — | $0 | 0 | SEC↗ |
| Woock John | Chief Marketing Officer | M Exercise | 2022-09-08 | 2022-09-12 | 3,800 | $1.42 | $5.4K | 49,776 | SEC↗ |
| Woock John | Chief Marketing Officer | S Sale | 2022-09-08 | 2022-09-12 | 3,800 | $75.01 | $285.0K | 45,976 | SEC↗ |
| Woock John | Chief Marketing Officer | M Exercise | 2022-09-08 | 2022-09-12 | 3,700 | $1.63 | $6.0K | 49,676 | SEC↗ |
| Woock John | Chief Marketing Officer | S Sale | 2022-09-08 | 2022-09-12 | 3,700 | $75.00 | $277.5K | 45,976 | SEC↗ |
| Noblett Karen | Chief Medical Officer | S Sale | 2022-09-07 | 2022-09-09 | 10,454 | $71.53 | $747.8K | 31,599 | SEC↗ |
| Woock John | Chief Marketing Officer | S Sale | 2022-08-25 | 2022-08-26 | 542 | $73.34 | $39.8K | 45,976 | SEC↗ |
| Woock John | Chief Marketing Officer | S Sale | 2022-08-25 | 2022-08-26 | 6,958 | $72.92 | $507.4K | 46,518 | SEC↗ |
| CARREL MICHAEL H | Director | A Award | 2022-08-18 | 2022-08-22 | 2,100 | — | $0 | 15,361 | SEC↗ |
| McNamara Robert | Director | A Award | 2022-08-18 | 2022-08-22 | 2,100 | — | $0 | 11,861 | SEC↗ |
| snyderman nancy lynn MD | Director | A Award | 2022-08-18 | 2022-08-22 | 2,100 | — | $0 | 16,944 | SEC↗ |
| Kiernan Jane E | Director | A Award | 2022-08-18 | 2022-08-22 | 2,100 | — | $0 | 16,861 | SEC↗ |
| Demski David M | Director | A Award | 2022-08-18 | 2022-08-22 | 2,100 | — | $0 | 6,542 | SEC↗ |
| Lopez Esteban | Director | A Award | 2022-08-18 | 2022-08-22 | 2,100 | — | $0 | 5,600 | SEC↗ |
| Dearen Danny L. | See Remarks | M Exercise deriv | 2022-08-11 | 2022-08-15 | 2,044 | — | $0 | 0 | SEC↗ |
| Dearen Danny L. | See Remarks | M Exercise deriv | 2022-08-11 | 2022-08-15 | 1,616 | — | $0 | 0 | SEC↗ |
| Dearen Danny L. | See Remarks | M Exercise deriv | 2022-08-11 | 2022-08-15 | 6,250 | — | $0 | 12,500 | SEC↗ |
| Dearen Danny L. | See Remarks | M Exercise deriv | 2022-08-11 | 2022-08-15 | 20,545 | — | $0 | 0 | SEC↗ |
| Dearen Danny L. | See Remarks | M Exercise deriv | 2022-08-11 | 2022-08-15 | 7,047 | — | $0 | 2,223 | SEC↗ |
| Dearen Danny L. | See Remarks | M Exercise | 2022-08-11 | 2022-08-15 | 7,047 | $14.19 | $100.0K | 51,906 | SEC↗ |
| Dearen Danny L. | See Remarks | M Exercise | 2022-08-11 | 2022-08-15 | 20,545 | $1.63 | $33.5K | 44,859 | SEC↗ |
| Dearen Danny L. | See Remarks | M Exercise | 2022-08-11 | 2022-08-15 | 2,044 | $1.32 | $2.7K | 24,314 | SEC↗ |
| Dearen Danny L. | See Remarks | M Exercise | 2022-08-11 | 2022-08-15 | 1,616 | $1.32 | $2.1K | 22,270 | SEC↗ |
| Dearen Danny L. | See Remarks | S Sale | 2022-08-11 | 2022-08-15 | 6,960 | $72.19 | $502.4K | 8,156 | SEC↗ |
| Dearen Danny L. | See Remarks | S Sale | 2022-08-11 | 2022-08-15 | 16,280 | $71.26 | $1.16M | 15,116 | SEC↗ |
| Dearen Danny L. | See Remarks | S Sale | 2022-08-11 | 2022-08-15 | 26,760 | $70.33 | $1.88M | 31,396 | SEC↗ |
| Dearen Danny L. | See Remarks | M Exercise | 2022-08-11 | 2022-08-15 | 6,250 | $25.82 | $161.4K | 58,156 | SEC↗ |
| Sama Rinda | Chief Operating Officer | M Exercise deriv | 2022-08-10 | 2022-08-12 | 25,549 | — | $0 | 11,019 | SEC↗ |
| Sama Rinda | Chief Operating Officer | M Exercise deriv | 2022-08-10 | 2022-08-12 | 8,301 | — | $0 | 9,962 | SEC↗ |
| Woock John | Chief Marketing Officer | M Exercise deriv | 2022-08-10 | 2022-08-12 | 7,500 | — | $0 | 3,700 | SEC↗ |
| Sama Rinda | Chief Operating Officer | M Exercise | 2022-08-10 | 2022-08-12 | 16,177 | $14.19 | $229.6K | 70,835 | SEC↗ |
| Sama Rinda | Chief Operating Officer | M Exercise | 2022-08-10 | 2022-08-12 | 8,301 | $25.82 | $214.3K | 79,136 | SEC↗ |
| Sama Rinda | Chief Operating Officer | S Sale | 2022-08-10 | 2022-08-12 | 24,478 | $69.35 | $1.70M | 64,030 | SEC↗ |
| Sama Rinda | Chief Operating Officer | S Sale | 2022-08-10 | 2022-08-12 | 9,372 | $70.12 | $657.2K | 54,658 | SEC↗ |
| Sama Rinda | Chief Operating Officer | M Exercise | 2022-08-10 | 2022-08-12 | 9,372 | $14.19 | $133.0K | 88,508 | SEC↗ |
| Woock John | Chief Marketing Officer | S Sale | 2022-08-10 | 2022-08-12 | 9,151 | $69.46 | $635.6K | 59,325 | SEC↗ |
| Woock John | Chief Marketing Officer | M Exercise | 2022-08-10 | 2022-08-12 | 7,500 | $1.63 | $12.2K | 68,476 | SEC↗ |
| Woock John | Chief Marketing Officer | S Sale | 2022-08-10 | 2022-08-12 | 5,849 | $70.10 | $410.0K | 53,476 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | S Sale | 2022-08-08 | 2022-08-10 | 12,092 | $70.40 | $851.3K | 163,443 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | S Sale | 2022-08-08 | 2022-08-10 | 12,032 | $71.65 | $862.1K | 151,411 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | S Sale | 2022-08-08 | 2022-08-10 | 1,776 | $72.09 | $128.0K | 149,635 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | S Sale | 2022-08-08 | 2022-08-10 | 18,100 | $69.50 | $1.26M | 175,535 | SEC↗ |
| Sama Rinda | Chief Operating Officer | S Sale | 2022-08-05 | 2022-08-09 | 12,694 | $70.86 | $899.5K | 55,058 | SEC↗ |
| Sama Rinda | Chief Operating Officer | S Sale | 2022-08-05 | 2022-08-09 | 400 | $71.40 | $28.6K | 54,658 | SEC↗ |
| Kiernan Jane E | Director | S Sale | 2022-07-05 | 2022-07-07 | 5,250 | $60.00 | $315.0K | 14,761 | SEC↗ |
| Kiernan Jane E | Director | S Sale | 2022-04-01 | 2022-07-07 | 1,750 | $62.71 | $109.7K | 20,011 | SEC↗ |
| Kiernan Jane E | Director | S Sale | 2022-03-29 | 2022-03-31 | 3,500 | $60.00 | $210.0K | 9,344 | SEC↗ |
| Kiernan Jane E | Director | S Sale | 2022-03-29 | 2022-03-31 | 1,750 | $61.49 | $107.6K | 7,594 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | S Sale | 2022-03-29 | 2022-03-31 | 50,000 | $60.00 | $3.00M | 193,635 | SEC↗ |
| Noblett Karen | Chief Medical Officer | S Sale | 2022-03-18 | 2022-03-22 | 13,531 | $57.23 | $774.4K | 42,053 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | S Sale | 2022-03-14 | 2022-03-16 | 1,981 | $52.66 | $104.3K | 271,767 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | S Sale | 2022-03-14 | 2022-03-16 | 11,232 | $53.95 | $606.0K | 260,535 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | S Sale | 2022-03-14 | 2022-03-16 | 16,900 | $54.80 | $926.1K | 243,635 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | S Sale | 2022-03-14 | 2022-03-16 | 2,100 | $51.40 | $107.9K | 273,748 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | S Sale | 2022-03-14 | 2022-03-16 | 17,787 | $50.42 | $896.8K | 275,848 | SEC↗ |
| Dearen Danny L. | See Remarks | M Exercise deriv | 2022-03-01 | 2022-03-03 | 12,329 | — | $0 | 2,343 | SEC↗ |
| Dearen Danny L. | See Remarks | S Sale | 2022-03-01 | 2022-03-03 | 7,846 | $57.40 | $450.4K | 31,218 | SEC↗ |
| Dearen Danny L. | See Remarks | S Sale | 2022-03-01 | 2022-03-03 | 1,500 | $56.32 | $84.5K | 39,064 | SEC↗ |
| Dearen Danny L. | See Remarks | S Sale | 2022-03-01 | 2022-03-03 | 10,564 | $58.11 | $613.9K | 20,654 | SEC↗ |
| Dearen Danny L. | See Remarks | M Exercise | 2022-03-01 | 2022-03-03 | 12,329 | $25.82 | $318.3K | 40,564 | SEC↗ |
| Dearen Danny L. | See Remarks | M Exercise deriv | 2022-02-25 | 2022-03-01 | 6,421 | — | $0 | 14,672 | SEC↗ |
| Dearen Danny L. | See Remarks | M Exercise deriv | 2022-02-25 | 2022-03-01 | 3,579 | — | $0 | 6,666 | SEC↗ |
| Dearen Danny L. | See Remarks | M Exercise | 2022-02-25 | 2022-03-01 | 3,579 | $14.19 | $50.8K | 38,235 | SEC↗ |
| Dearen Danny L. | See Remarks | S Sale | 2022-02-25 | 2022-03-01 | 10,000 | $57.00 | $570.0K | 28,235 | SEC↗ |
| Dearen Danny L. | See Remarks | M Exercise | 2022-02-25 | 2022-03-01 | 6,421 | $25.82 | $165.8K | 34,656 | SEC↗ |
| Dearen Danny L. | President & CFO | S Sale | 2022-02-03 | 2023-10-03 | 17,737 | $48.21 | $855.1K | 40,182 | SEC↗ |
| Dearen Danny L. | President & CFO | S Sale | 2022-02-03 | 2023-10-03 | 947 | $49.03 | $46.4K | 39,235 | SEC↗ |
| Dearen Danny L. | President & CFO | M Exercise | 2022-02-03 | 2023-10-03 | 36,919 | — | $0 | 57,919 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | M Exercise deriv | 2022-02-03 | 2022-02-03 | 54,346 | — | $0 | 0 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | M Exercise deriv | 2022-02-03 | 2022-02-03 | 42,500 | — | $0 | 0 | SEC↗ |
| Dearen Danny L. | See Remarks | M Exercise deriv | 2022-02-03 | 2022-02-03 | 26,086 | — | $0 | 0 | SEC↗ |
| Dearen Danny L. | See Remarks | M Exercise deriv | 2022-02-03 | 2022-02-03 | 10,833 | — | $0 | 0 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | M Exercise deriv | 2022-02-03 | 2022-02-03 | 10,000 | — | $0 | 0 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | M Exercise deriv | 2022-02-03 | 2022-02-03 | 14,130 | — | $0 | 0 | SEC↗ |
| Woock John | Chief Marketing Officer | M Exercise deriv | 2022-02-03 | 2022-02-03 | 10,000 | — | $0 | 0 | SEC↗ |
| Woock John | Chief Marketing Officer | M Exercise deriv | 2022-02-03 | 2022-02-03 | 10,870 | — | $0 | 0 | SEC↗ |
| Sama Rinda | Chief Operating Officer | M Exercise deriv | 2022-02-03 | 2022-02-03 | 10,833 | — | $0 | 0 | SEC↗ |
| Sama Rinda | Chief Operating Officer | M Exercise deriv | 2022-02-03 | 2022-02-03 | 18,478 | — | $0 | 0 | SEC↗ |
| Noblett Karen | Chief Medical Officer | M Exercise deriv | 2022-02-03 | 2022-02-03 | 14,130 | — | $0 | 0 | SEC↗ |
| Noblett Karen | Chief Medical Officer | M Exercise deriv | 2022-02-03 | 2022-02-03 | 5,333 | — | $0 | 0 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | M Exercise | 2022-02-03 | 2022-02-03 | 96,846 | — | $0 | 374,750 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | S Sale | 2022-02-03 | 2022-02-03 | 33,336 | $48.21 | $1.61M | 341,414 | SEC↗ |
| COHEN RAYMOND W | Chief Executive Officer | S Sale | 2022-02-03 | 2022-02-03 | 1,779 | $49.03 | $87.2K | 339,635 | SEC↗ |
| Dearen Danny L. | See Remarks | S Sale | 2022-02-03 | 2022-02-03 | 947 | $49.03 | $46.4K | 28,235 | SEC↗ |
| Dearen Danny L. | See Remarks | M Exercise | 2022-02-03 | 2022-02-03 | 36,919 | — | $0 | 46,919 | SEC↗ |
| Dearen Danny L. | See Remarks | S Sale | 2022-02-03 | 2022-02-03 | 17,737 | $48.21 | $855.1K | 29,182 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | M Exercise | 2022-02-03 | 2022-02-03 | 24,130 | — | $0 | 46,040 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | S Sale | 2022-02-03 | 2022-02-03 | 8,797 | $48.21 | $424.1K | 37,243 | SEC↗ |
| Ford Alfred J Jr | Chief Commercial Officer | S Sale | 2022-02-03 | 2022-02-03 | 470 | $49.03 | $23.0K | 36,773 | SEC↗ |
| Woock John | Chief Marketing Officer | M Exercise | 2022-02-03 | 2022-02-03 | 20,870 | — | $0 | 67,227 | SEC↗ |
| Woock John | Chief Marketing Officer | S Sale | 2022-02-03 | 2022-02-03 | 5,934 | $48.21 | $286.1K | 61,293 | SEC↗ |
| Woock John | Chief Marketing Officer | S Sale | 2022-02-03 | 2022-02-03 | 317 | $49.03 | $15.5K | 60,976 | SEC↗ |
| Sama Rinda | Chief Operating Officer | S Sale | 2022-02-03 | 2022-02-03 | 602 | $49.03 | $29.5K | 67,752 | SEC↗ |
| Sama Rinda | Chief Operating Officer | M Exercise | 2022-02-03 | 2022-02-03 | 29,311 | — | $0 | 79,634 | SEC↗ |
| Sama Rinda | Chief Operating Officer | S Sale | 2022-02-03 | 2022-02-03 | 11,280 | $48.21 | $543.8K | 68,354 | SEC↗ |
| Noblett Karen | Chief Medical Officer | S Sale | 2022-02-03 | 2022-02-03 | 339 | $49.03 | $16.6K | 55,584 | SEC↗ |
| Noblett Karen | Chief Medical Officer | M Exercise | 2022-02-03 | 2022-02-03 | 19,463 | — | $0 | 62,266 | SEC↗ |
| Noblett Karen | Chief Medical Officer | S Sale | 2022-02-03 | 2022-02-03 | 6,343 | $48.21 | $305.8K | 55,923 | SEC↗ |
| Dearen Danny L. | See Remarks | M Exercise deriv | 2022-02-01 | 2022-02-03 | 20,000 | — | $0 | 32,468 | SEC↗ |
| Dearen Danny L. | See Remarks | S Sale | 2022-02-01 | 2022-02-03 | 3,730 | $48.26 | $180.0K | 24,253 | SEC↗ |
| Dearen Danny L. | See Remarks | M Exercise | 2022-02-01 | 2022-02-03 | 20,000 | $14.19 | $283.8K | 30,000 | SEC↗ |
| Dearen Danny L. | See Remarks | S Sale | 2022-02-01 | 2022-02-03 | 13,853 | $49.07 | $679.8K | 10,400 | SEC↗ |
| Dearen Danny L. | See Remarks | S Sale | 2022-02-01 | 2022-02-03 | 400 | $49.70 | $19.9K | 10,000 | SEC↗ |