Open-mkt buys · 90d
—
0 trades · 0 insiders
Open-mkt sales · 90d
—
0 trades · 0 insiders
Net · 90d
$0
Insiders on file
23
Daily buy vs sell · 90 days
No data yet.
Insiders
| Insider | Role | Trades | Bought | Sold | Last trade |
|---|---|---|---|---|---|
| Orwin John A | President & CEO | 17 | $76.7K | $45.7K | 2024-04-11 |
| Serafini Tito | Director | 56 | $0 | $2.61M | 2024-04-01 |
| BAKER JULIAN | Other | 4 | $12.50M | $109.9K | 2023-10-19 |
| Courtney Phillips | General Counsel & Secretary | 18 | $0 | $17.9K | 2023-09-01 |
| Gould Stephen E | Chief Scientific Officer | 4 | $0 | $3.9K | 2023-08-02 |
| CROSS HERB | Chief Financial Officer | 14 | $0 | $18.8K | 2023-08-02 |
| Ma Stacey | Director | 3 | $0 | $0 | 2023-06-13 |
| Robinson William Hewitt | Director | 33 | $0 | $1.32M | 2023-06-13 |
| Lacey David L. | Director | 4 | $0 | $0 | 2023-06-13 |
| Rolfe Lindsey | Director | 5 | $0 | $0 | 2023-06-13 |
| Brady Stephen R | Director | 3 | $0 | $0 | 2023-06-13 |
| BERGER FRANKLIN M | Director | 8 | $0 | $0 | 2023-06-13 |
| ATWOOD BRIAN G | Director | 13 | $0 | $0 | 2023-06-13 |
| BALL KRISTINE M | Director | 5 | $0 | $0 | 2023-06-13 |
| Bishop Philippe C | Chief Medical Officer | 1 | $0 | $0 | 2023-01-09 |
| Greenberg Norman Michael | Chief Scientific Officer | 70 | $0 | $2.37M | 2021-03-17 |
| Decker Lisa Lynn | Chief Business Officer | 2 | $0 | $0 | 2021-01-27 |
| BAKER BROS. ADVISORS LP | 10% Owner | 14 | $46.50M | $0 | 2020-07-20 |
| Cavet Guy | Chief Technical Officer | 9 | $0 | $449.6K | 2020-02-25 |
| Hadley Harbor Master Investors (Cayman) II L.P. | 10% Owner | 4 | $0 | $0 | 2019-06-24 |
| Bill & Melinda Gates Foundation | 10% Owner | 2 | $0 | $0 | 2019-06-24 |
| Redmile Group, LLC | 10% Owner | 2 | $0 | $0 | 2019-06-24 |
| STEINMAN LAWRENCE | Director | 2 | $0 | $0 | 2019-06-24 |
Trade history
| Insider | Role | Code | Trade | Filed | Shares | Price | Value | Owned after | |
|---|---|---|---|---|---|---|---|---|---|
| Orwin John A | PRESIDENT & CEO | P Buy | 2024-04-11 | 2024-04-17 | 1 | $0.01 | $0 | 1 | SEC↗ |
| Serafini Tito | Director | S Sale | 2024-04-01 | 2024-04-03 | 20,788 | $0.07 | $1.5K | 43,636 | SEC↗ |
| BAKER JULIAN | Other | S Sale | 2023-10-19 | 2023-10-23 | 251,902 | $0.40 | $100.8K | 2,971,128 | SEC↗ |
| BAKER JULIAN | Other | S Sale | 2023-10-19 | 2023-10-23 | 22,837 | $0.40 | $9.1K | 286,893 | SEC↗ |
| Courtney Phillips | GENERAL COUNSEL & SECRETARY | S Sale | 2023-09-01 | 2024-04-03 | 7,061 | $0.37 | $2.6K | 50,431 | SEC↗ |
| Serafini Tito | Director | S Sale | 2023-09-01 | 2024-04-03 | 8,393 | $0.37 | $3.1K | 64,424 | SEC↗ |
| Orwin John A | PRESIDENT & CEO | S Sale | 2023-09-01 | 2024-04-03 | 22,951 | $0.37 | $8.5K | 77,541 | SEC↗ |
| Courtney Phillips | General Counsel & Secretary | S Sale | 2023-08-02 | 2023-08-04 | 4,076 | $0.95 | $3.9K | 57,492 | SEC↗ |
| Gould Stephen E | Chief Scientific Officer | S Sale | 2023-08-02 | 2023-08-04 | 4,076 | $0.95 | $3.9K | 28,424 | SEC↗ |
| CROSS HERB | Chief Financial Officer | S Sale | 2023-08-02 | 2023-08-04 | 5,487 | $0.95 | $5.2K | 72,817 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2023-08-02 | 2023-08-04 | 5,487 | $0.95 | $5.2K | 72,817 | SEC↗ |
| ATWOOD BRIAN G | Director | A Award deriv | 2023-06-13 | 2023-06-15 | 12,000 | — | $0 | 12,000 | SEC↗ |
| BALL KRISTINE M | Director | A Award deriv | 2023-06-13 | 2023-06-15 | 12,000 | — | $0 | 12,000 | SEC↗ |
| BERGER FRANKLIN M | Director | A Award deriv | 2023-06-13 | 2023-06-15 | 12,000 | — | $0 | 12,000 | SEC↗ |
| Brady Stephen R | Director | A Award deriv | 2023-06-13 | 2023-06-15 | 12,000 | — | $0 | 12,000 | SEC↗ |
| Lacey David L. | Director | A Award deriv | 2023-06-13 | 2023-06-15 | 12,000 | — | $0 | 12,000 | SEC↗ |
| Ma Stacey | Director | A Award deriv | 2023-06-13 | 2023-06-15 | 12,000 | — | $0 | 12,000 | SEC↗ |
| Robinson William Hewitt | Director | A Award deriv | 2023-06-13 | 2023-06-15 | 12,000 | — | $0 | 12,000 | SEC↗ |
| Rolfe Lindsey | Director | A Award deriv | 2023-06-13 | 2023-06-15 | 12,000 | — | $0 | 12,000 | SEC↗ |
| Gould Stephen E | Chief Scientific Officer | A Award deriv | 2023-02-09 | 2023-02-13 | 130,000 | — | $0 | 130,000 | SEC↗ |
| Courtney Phillips | General Counsel & Secretary | A Award deriv | 2023-02-09 | 2023-02-13 | 130,000 | — | $0 | 130,000 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | A Award deriv | 2023-02-09 | 2023-02-13 | 175,000 | — | $0 | 175,000 | SEC↗ |
| CROSS HERB | Chief Financial Officer | A Award deriv | 2023-02-09 | 2023-02-13 | 175,000 | — | $0 | 175,000 | SEC↗ |
| Orwin John A | President & CEO | A Award deriv | 2023-02-09 | 2023-02-13 | 435,000 | — | $0 | 435,000 | SEC↗ |
| Gould Stephen E | Chief Scientific Officer | A Award | 2023-02-09 | 2023-02-13 | 32,500 | — | $0 | 32,500 | SEC↗ |
| Courtney Phillips | General Counsel & Secretary | A Award | 2023-02-09 | 2023-02-13 | 32,500 | — | $0 | 61,568 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | A Award | 2023-02-09 | 2023-02-13 | 43,750 | — | $0 | 78,304 | SEC↗ |
| CROSS HERB | Chief Financial Officer | A Award | 2023-02-09 | 2023-02-13 | 43,750 | — | $0 | 78,304 | SEC↗ |
| Bishop Philippe C | Chief Medical Officer | A Award deriv | 2023-01-09 | 2023-01-11 | 350,000 | — | $0 | 350,000 | SEC↗ |
| Courtney Phillips | General Counsel & Secretary | S Sale | 2022-09-02 | 2022-09-20 | 6,432 | $1.78 | $11.4K | 29,068 | SEC↗ |
| CROSS HERB | Chief Financial Officer | S Sale | 2022-09-02 | 2022-09-20 | 7,646 | $1.78 | $13.6K | 34,554 | SEC↗ |
| Orwin John A | President & CEO | S Sale | 2022-09-02 | 2022-09-20 | 20,908 | $1.78 | $37.2K | 100,492 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2022-09-02 | 2022-09-20 | 7,646 | $1.78 | $13.6K | 34,554 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2022-06-28 | 2022-06-30 | 15,000 | $2.02 | $30.3K | 228,875 | SEC↗ |
| Gould Stephen E | Chief Scientific Officer | A Award deriv | 2022-06-15 | 2022-06-17 | 200,000 | — | $0 | 200,000 | SEC↗ |
| CROSS HERB | Chief Financial Officer | D To issuer deriv | 2022-06-13 | 2022-06-15 | 95,000 | — | $0 | 0 | SEC↗ |
| CROSS HERB | Chief Financial Officer | A Award deriv | 2022-06-13 | 2022-06-15 | 95,000 | — | $0 | 95,000 | SEC↗ |
| CROSS HERB | Chief Financial Officer | A Award deriv | 2022-06-13 | 2022-06-15 | 224,999 | — | $0 | 224,999 | SEC↗ |
| CROSS HERB | Chief Financial Officer | D To issuer deriv | 2022-06-13 | 2022-06-15 | 224,999 | — | $0 | 0 | SEC↗ |
| CROSS HERB | Chief Financial Officer | A Award deriv | 2022-06-13 | 2022-06-15 | 97,000 | — | $0 | 97,000 | SEC↗ |
| CROSS HERB | Chief Financial Officer | D To issuer deriv | 2022-06-13 | 2022-06-15 | 97,000 | — | $0 | 0 | SEC↗ |
| Orwin John A | President & CEO | D To issuer deriv | 2022-06-13 | 2022-06-15 | 260,000 | — | $0 | 0 | SEC↗ |
| Orwin John A | President & CEO | A Award deriv | 2022-06-13 | 2022-06-15 | 241,000 | — | $0 | 241,000 | SEC↗ |
| Orwin John A | President & CEO | A Award deriv | 2022-06-13 | 2022-06-15 | 260,000 | — | $0 | 260,000 | SEC↗ |
| Orwin John A | President & CEO | D To issuer deriv | 2022-06-13 | 2022-06-15 | 241,000 | — | $0 | 0 | SEC↗ |
| Orwin John A | President & CEO | A Award deriv | 2022-06-13 | 2022-06-15 | 148,754 | — | $0 | 148,754 | SEC↗ |
| Orwin John A | President & CEO | D To issuer deriv | 2022-06-13 | 2022-06-15 | 148,754 | — | $0 | 0 | SEC↗ |
| Orwin John A | President & CEO | A Award deriv | 2022-06-13 | 2022-06-15 | 58,995 | — | $0 | 58,995 | SEC↗ |
| Orwin John A | President & CEO | D To issuer deriv | 2022-06-13 | 2022-06-15 | 58,995 | — | $0 | 0 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | A Award deriv | 2022-06-13 | 2022-06-15 | 95,000 | — | $0 | 95,000 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | D To issuer deriv | 2022-06-13 | 2022-06-15 | 50,145 | — | $0 | 0 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | A Award deriv | 2022-06-13 | 2022-06-15 | 88,000 | — | $0 | 88,000 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | D To issuer deriv | 2022-06-13 | 2022-06-15 | 141,395 | — | $0 | 0 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | A Award deriv | 2022-06-13 | 2022-06-15 | 141,395 | — | $0 | 141,395 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | D To issuer deriv | 2022-06-13 | 2022-06-15 | 88,000 | — | $0 | 0 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | A Award deriv | 2022-06-13 | 2022-06-15 | 50,145 | — | $0 | 50,145 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | D To issuer deriv | 2022-06-13 | 2022-06-15 | 95,000 | — | $0 | 0 | SEC↗ |
| Courtney Phillips | General Counsel & Secretary | A Award deriv | 2022-06-13 | 2022-06-15 | 65,000 | — | $0 | 65,000 | SEC↗ |
| Courtney Phillips | General Counsel & Secretary | D To issuer deriv | 2022-06-13 | 2022-06-15 | 91,666 | — | $0 | 0 | SEC↗ |
| Courtney Phillips | General Counsel & Secretary | A Award deriv | 2022-06-13 | 2022-06-15 | 91,666 | — | $0 | 91,666 | SEC↗ |
| Courtney Phillips | General Counsel & Secretary | D To issuer deriv | 2022-06-13 | 2022-06-15 | 45,000 | — | $0 | 0 | SEC↗ |
| Courtney Phillips | General Counsel & Secretary | A Award deriv | 2022-06-13 | 2022-06-15 | 45,000 | — | $0 | 45,000 | SEC↗ |
| Courtney Phillips | General Counsel & Secretary | D To issuer deriv | 2022-06-13 | 2022-06-15 | 80,000 | — | $0 | 0 | SEC↗ |
| Courtney Phillips | General Counsel & Secretary | A Award deriv | 2022-06-13 | 2022-06-15 | 80,000 | — | $0 | 80,000 | SEC↗ |
| Courtney Phillips | General Counsel & Secretary | D To issuer deriv | 2022-06-13 | 2022-06-15 | 65,000 | — | $0 | 0 | SEC↗ |
| Robinson William Hewitt | Director | A Award deriv | 2022-06-08 | 2022-06-10 | 12,000 | — | $0 | 12,000 | SEC↗ |
| BERGER FRANKLIN M | Director | A Award deriv | 2022-06-08 | 2022-06-10 | 12,000 | — | $0 | 12,000 | SEC↗ |
| Rolfe Lindsey | Director | A Award deriv | 2022-06-08 | 2022-06-10 | 12,000 | — | $0 | 12,000 | SEC↗ |
| Ma Stacey | Director | A Award deriv | 2022-06-08 | 2022-06-10 | 12,000 | — | $0 | 12,000 | SEC↗ |
| Lacey David L. | Director | A Award deriv | 2022-06-08 | 2022-06-10 | 12,000 | — | $0 | 12,000 | SEC↗ |
| Brady Stephen R | Director | A Award deriv | 2022-06-08 | 2022-06-10 | 12,000 | — | $0 | 12,000 | SEC↗ |
| BALL KRISTINE M | Director | A Award deriv | 2022-06-08 | 2022-06-10 | 12,000 | — | $0 | 12,000 | SEC↗ |
| ATWOOD BRIAN G | Director | A Award deriv | 2022-06-08 | 2022-06-13 | 12,000 | — | $0 | 12,000 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2022-03-04 | 2022-03-08 | 30,000 | $5.00 | $150.0K | 243,875 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | A Award deriv | 2021-12-23 | 2021-12-28 | 95,000 | — | $0 | 95,000 | SEC↗ |
| Orwin John A | President & CEO | A Award deriv | 2021-12-23 | 2021-12-28 | 260,000 | — | $0 | 260,000 | SEC↗ |
| CROSS HERB | Chief Financial Officer | A Award deriv | 2021-12-23 | 2021-12-28 | 95,000 | — | $0 | 95,000 | SEC↗ |
| Courtney Phillips | General Counsel & Secretary | A Award deriv | 2021-12-23 | 2021-12-28 | 80,000 | — | $0 | 80,000 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2021-09-27 | 2021-09-28 | 30,000 | $6.58 | $197.4K | 273,875 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | G Gift | 2021-09-20 | 2021-09-28 | 50,000 | — | $0 | 50,000 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | G Gift | 2021-09-20 | 2021-09-28 | 50,000 | — | $0 | 303,875 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | A Award | 2021-09-09 | 2021-09-13 | 42,200 | — | $0 | 42,200 | SEC↗ |
| Courtney Phillips | General Counsel & Secretary | A Award | 2021-09-09 | 2021-09-13 | 35,500 | — | $0 | 35,500 | SEC↗ |
| CROSS HERB | Chief Financial Officer | A Award | 2021-09-09 | 2021-09-13 | 42,200 | — | $0 | 42,200 | SEC↗ |
| Orwin John A | President & CEO | A Award | 2021-09-09 | 2021-09-13 | 115,400 | — | $0 | 121,400 | SEC↗ |
| Ma Stacey | Director | A Award deriv | 2021-07-14 | 2021-07-16 | 24,000 | — | $0 | 24,000 | SEC↗ |
| Brady Stephen R | Director | A Award deriv | 2021-07-14 | 2021-07-16 | 24,000 | — | $0 | 24,000 | SEC↗ |
| Rolfe Lindsey | Director | A Award deriv | 2021-06-09 | 2021-06-11 | 12,000 | — | $0 | 12,000 | SEC↗ |
| Robinson William Hewitt | Director | A Award deriv | 2021-06-09 | 2021-06-11 | 12,000 | — | $0 | 12,000 | SEC↗ |
| Lacey David L. | Director | A Award deriv | 2021-06-09 | 2021-06-11 | 12,000 | — | $0 | 12,000 | SEC↗ |
| BERGER FRANKLIN M | Director | A Award deriv | 2021-06-09 | 2021-06-11 | 12,000 | — | $0 | 12,000 | SEC↗ |
| BALL KRISTINE M | Director | A Award deriv | 2021-06-09 | 2021-06-11 | 12,000 | — | $0 | 12,000 | SEC↗ |
| ATWOOD BRIAN G | Director | A Award deriv | 2021-06-09 | 2021-06-11 | 12,000 | — | $0 | 12,000 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise deriv | 2021-03-17 | 2021-03-19 | 2,084 | — | $0 | 32,915 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise deriv | 2021-03-17 | 2021-03-19 | 2,916 | — | $0 | 9,013 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2021-03-17 | 2021-03-19 | 2,084 | $16.73 | $34.9K | 0 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise | 2021-03-17 | 2021-03-19 | 2,916 | $4.56 | $13.3K | 2,916 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise | 2021-03-17 | 2021-03-19 | 2,084 | $5.16 | $10.8K | 2,084 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2021-03-17 | 2021-03-19 | 2,916 | $16.73 | $48.8K | 0 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2021-03-15 | 2021-03-16 | 5,000 | $16.89 | $84.5K | 368,948 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2021-03-11 | 2021-03-15 | 1,500 | $18.84 | $28.3K | 353,875 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2021-03-11 | 2021-03-15 | 8,500 | $18.22 | $154.9K | 355,375 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise deriv | 2021-02-17 | 2021-02-19 | 5,000 | — | $0 | 34,999 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise | 2021-02-17 | 2021-02-19 | 5,000 | $5.16 | $25.8K | 5,000 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2021-02-17 | 2021-02-19 | 5,000 | $18.95 | $94.8K | 0 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2021-02-16 | 2021-02-18 | 5,000 | $19.07 | $95.3K | 373,948 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2021-02-11 | 2021-02-16 | 10,000 | $18.93 | $189.3K | 363,875 | SEC↗ |
| CROSS HERB | Chief Financial Officer | A Award deriv | 2021-01-27 | 2021-01-29 | 95,000 | — | $0 | 95,000 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | A Award deriv | 2021-01-27 | 2021-01-29 | 95,000 | — | $0 | 95,000 | SEC↗ |
| Decker Lisa Lynn | Chief Business Officer | A Award deriv | 2021-01-27 | 2021-01-29 | 80,000 | — | $0 | 80,000 | SEC↗ |
| Orwin John A | President & CEO | A Award deriv | 2021-01-27 | 2021-01-29 | 260,000 | — | $0 | 260,000 | SEC↗ |
| Courtney Phillips | General Counsel & Secretary | A Award deriv | 2021-01-27 | 2021-01-29 | 80,000 | — | $0 | 80,000 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | A Award deriv | 2021-01-27 | 2021-01-29 | 95,000 | — | $0 | 95,000 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise deriv | 2021-01-19 | 2021-01-21 | 5,000 | — | $0 | 39,999 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2021-01-19 | 2021-01-21 | 5,000 | $15.21 | $76.0K | 0 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise | 2021-01-19 | 2021-01-21 | 5,000 | $5.16 | $25.8K | 5,000 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2021-01-14 | 2021-01-15 | 2,259 | $15.06 | $34.0K | 378,948 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2021-01-13 | 2021-01-15 | 2,741 | $15.05 | $41.3K | 381,207 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2021-01-11 | 2021-01-13 | 10,000 | $15.02 | $150.2K | 373,875 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise deriv | 2020-12-17 | 2021-01-21 | 5,000 | — | $0 | 44,999 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise | 2020-12-17 | 2021-01-21 | 5,000 | $5.16 | $25.8K | 5,000 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise deriv | 2020-12-17 | 2020-12-21 | 5,000 | — | $0 | 6,929 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise | 2020-12-17 | 2020-12-21 | 5,000 | $4.56 | $22.8K | 5,000 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2020-12-17 | 2020-12-21 | 5,000 | $16.61 | $83.0K | 0 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2020-12-14 | 2020-12-15 | 5,000 | $16.67 | $83.4K | 383,948 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2020-12-11 | 2020-12-15 | 10,000 | $15.87 | $158.7K | 383,875 | SEC↗ |
| ATWOOD BRIAN G | Director | G Gift deriv | 2020-12-09 | 2020-12-10 | 12,500 | — | $0 | 12,500 | SEC↗ |
| ATWOOD BRIAN G | Director | G Gift deriv | 2020-12-09 | 2020-12-10 | 12,000 | — | $0 | 0 | SEC↗ |
| ATWOOD BRIAN G | Director | G Gift deriv | 2020-12-09 | 2020-12-10 | 12,000 | — | $0 | 12,000 | SEC↗ |
| ATWOOD BRIAN G | Director | G Gift deriv | 2020-12-09 | 2020-12-10 | 12,500 | — | $0 | 0 | SEC↗ |
| ATWOOD BRIAN G | Director | G Gift deriv | 2020-12-09 | 2020-12-10 | 34,166 | — | $0 | 0 | SEC↗ |
| ATWOOD BRIAN G | Director | G Gift deriv | 2020-12-09 | 2020-12-10 | 34,166 | — | $0 | 34,166 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise deriv | 2020-11-27 | 2020-12-01 | 3,175 | — | $0 | 11,929 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2020-11-27 | 2020-12-01 | 3,175 | $15.34 | $48.7K | 0 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise | 2020-11-27 | 2020-12-01 | 3,175 | $4.56 | $14.5K | 3,175 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise deriv | 2020-11-17 | 2020-11-18 | 1,825 | — | $0 | 15,104 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise | 2020-11-17 | 2020-11-18 | 1,825 | $4.56 | $8.3K | 1,825 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2020-11-17 | 2020-11-18 | 1,825 | $15.04 | $27.4K | 0 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2020-11-16 | 2020-11-17 | 8,847 | $15.12 | $133.8K | 393,875 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2020-11-16 | 2020-11-17 | 5,000 | $15.00 | $75.0K | 388,948 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | G Gift | 2020-11-12 | 2020-11-13 | 3,655 | — | $0 | 3,655 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | G Gift | 2020-11-12 | 2020-11-13 | 3,655 | — | $0 | 0 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2020-11-11 | 2020-11-13 | 1,153 | $15.10 | $17.4K | 399,067 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise | 2020-11-10 | 2020-11-12 | 4,500 | $4.56 | $20.5K | 4,500 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2020-11-10 | 2020-11-12 | 4,500 | $15.10 | $68.0K | 0 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise deriv | 2020-10-19 | 2020-10-21 | 500 | — | $0 | 21,429 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise deriv | 2020-10-19 | 2020-11-12 | 4,500 | — | $0 | 16,929 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise | 2020-10-19 | 2020-10-21 | 500 | $4.56 | $2.3K | 500 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2020-10-19 | 2020-10-21 | 500 | $15.12 | $7.6K | 0 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2020-10-13 | 2020-10-16 | 5,000 | $15.71 | $78.5K | 393,948 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2020-10-12 | 2020-10-13 | 10,000 | $15.00 | $150.0K | 400,220 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2020-10-06 | 2020-10-08 | 1,218 | $15.05 | $18.3K | 410,220 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2020-09-18 | 2020-09-22 | 8,782 | $15.11 | $132.7K | 411,438 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2020-09-18 | 2020-09-22 | 5,000 | $15.04 | $75.2K | 398,948 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2020-08-14 | 2020-08-17 | 10,000 | $15.00 | $150.0K | 420,220 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2020-08-14 | 2020-08-17 | 5,000 | $15.00 | $75.0K | 403,948 | SEC↗ |
| BAKER JULIAN | 10% Owner | P Buy deriv | 2020-07-20 | 2020-07-20 | 728,370 | $16.00 | $11.65M | 6,173,327 | SEC↗ |
| BAKER JULIAN | 10% Owner | P Buy deriv | 2020-07-20 | 2020-07-20 | 52,880 | $16.00 | $846.1K | 542,114 | SEC↗ |
| BAKER BROS. ADVISORS LP | 10% Owner | P Buy deriv | 2020-07-20 | 2020-07-20 | 728,370 | $16.00 | $11.65M | 6,173,327 | SEC↗ |
| BAKER BROS. ADVISORS LP | 10% Owner | P Buy deriv | 2020-07-20 | 2020-07-20 | 52,880 | $16.00 | $846.1K | 542,114 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2020-07-13 | 2020-07-15 | 7,129 | $20.52 | $146.3K | 430,220 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2020-07-13 | 2020-07-15 | 2,871 | $19.41 | $55.7K | 437,349 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2020-07-13 | 2020-07-15 | 3,594 | $20.54 | $73.8K | 408,948 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2020-07-13 | 2020-07-15 | 1,406 | $19.43 | $27.3K | 412,542 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise deriv | 2020-07-01 | 2020-07-06 | 10,272 | — | $0 | 21,929 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2020-07-01 | 2020-07-06 | 7,346 | $21.69 | $159.3K | 2,926 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2020-07-01 | 2020-07-06 | 2,926 | $22.17 | $64.9K | 0 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise | 2020-07-01 | 2020-07-06 | 10,272 | $4.56 | $46.8K | 10,272 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2020-06-25 | 2020-06-29 | 600 | $25.02 | $15.0K | 413,948 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2020-06-25 | 2020-06-29 | 600 | $25.01 | $15.0K | 440,220 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2020-06-22 | 2020-06-23 | 496 | $20.05 | $9.9K | 440,820 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2020-06-22 | 2020-06-23 | 68 | $20.05 | $1.4K | 414,548 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2020-06-19 | 2020-06-23 | 4,604 | $20.03 | $92.2K | 441,316 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2020-06-19 | 2020-06-23 | 10,245 | $20.03 | $205.2K | 414,616 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2020-06-15 | 2020-06-17 | 2,194 | $19.13 | $42.0K | 424,861 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2020-06-15 | 2020-06-17 | 1,801 | $18.43 | $33.2K | 427,055 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2020-06-15 | 2020-06-17 | 1,005 | $17.48 | $17.6K | 428,856 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2020-06-11 | 2020-06-12 | 1,414 | $17.17 | $24.3K | 445,920 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2020-06-11 | 2020-06-12 | 8,586 | $16.35 | $140.4K | 447,334 | SEC↗ |
| Lacey David L. | Director | A Award deriv | 2020-06-10 | 2020-06-15 | 12,000 | — | $0 | 12,000 | SEC↗ |
| ATWOOD BRIAN G | Director | A Award deriv | 2020-06-10 | 2020-06-15 | 12,000 | — | $0 | 12,000 | SEC↗ |
| BERGER FRANKLIN M | Director | A Award deriv | 2020-06-10 | 2020-06-15 | 12,000 | — | $0 | 12,000 | SEC↗ |
| Robinson William Hewitt | Director | A Award deriv | 2020-06-10 | 2020-06-15 | 12,000 | — | $0 | 12,000 | SEC↗ |
| Rolfe Lindsey | Director | A Award deriv | 2020-06-10 | 2020-06-15 | 12,000 | — | $0 | 12,000 | SEC↗ |
| BALL KRISTINE M | Director | A Award deriv | 2020-06-10 | 2020-06-15 | 12,000 | — | $0 | 12,000 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise deriv | 2020-06-01 | 2020-06-03 | 15,000 | — | $0 | 32,201 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise | 2020-06-01 | 2020-06-03 | 15,000 | $4.56 | $68.4K | 15,000 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2020-06-01 | 2020-06-03 | 15,000 | $18.38 | $275.7K | 0 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2020-05-28 | 2020-05-29 | 700 | $20.01 | $14.0K | 455,920 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2020-05-28 | 2020-05-29 | 600 | $20.01 | $12.0K | 429,861 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2020-05-27 | 2020-05-29 | 100 | $20.00 | $2.0K | 456,620 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2020-05-26 | 2020-05-27 | 200 | $20.00 | $4.0K | 456,720 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2020-05-26 | 2020-05-27 | 387 | $20.00 | $7.7K | 430,461 | SEC↗ |
| BALL KRISTINE M | Director | A Award deriv | 2020-05-20 | 2020-05-21 | 24,000 | — | $0 | 24,000 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2020-05-18 | 2020-05-19 | 1,700 | $20.00 | $34.0K | 456,920 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2020-05-18 | 2020-05-19 | 1,600 | $20.00 | $32.0K | 430,848 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2020-05-15 | 2020-05-19 | 2,200 | $20.00 | $44.0K | 458,620 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2020-05-15 | 2020-05-19 | 2,100 | $20.00 | $42.0K | 432,448 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2020-05-13 | 2020-05-15 | 4,800 | $16.80 | $80.6K | 434,748 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2020-05-13 | 2020-05-15 | 200 | $17.32 | $3.5K | 434,548 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2020-05-11 | 2020-05-13 | 6,288 | $18.22 | $114.6K | 460,820 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2020-05-11 | 2020-05-13 | 3,712 | $17.64 | $65.5K | 467,108 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise deriv | 2020-05-07 | 2020-05-08 | 5,000 | — | $0 | 47,201 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2020-05-07 | 2020-05-08 | 5,000 | $18.00 | $90.0K | 0 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise | 2020-05-07 | 2020-05-08 | 5,000 | $4.56 | $22.8K | 5,000 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise deriv | 2020-05-01 | 2020-05-04 | 10,000 | — | $0 | 52,201 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise | 2020-05-01 | 2020-05-04 | 10,000 | $4.56 | $45.6K | 10,000 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2020-05-01 | 2020-05-04 | 10,000 | $15.03 | $150.3K | 0 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2020-04-16 | 2020-04-20 | 500 | $17.72 | $8.9K | 439,548 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2020-04-16 | 2020-04-20 | 1,300 | $16.94 | $22.0K | 440,048 | SEC↗ |
| Robinson William Hewitt | Director | S Sale | 2020-04-16 | 2020-04-20 | 3,200 | $15.75 | $50.4K | 441,348 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2020-04-16 | 2020-04-20 | 800 | $17.74 | $14.2K | 470,820 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2020-04-16 | 2020-04-20 | 2,919 | $17.01 | $49.7K | 471,620 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | S Sale | 2020-04-16 | 2020-04-20 | 6,281 | $15.75 | $98.9K | 474,539 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise deriv | 2020-04-14 | 2020-04-16 | 5,000 | — | $0 | 62,201 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise | 2020-04-14 | 2020-04-16 | 5,000 | $4.56 | $22.8K | 5,000 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2020-04-14 | 2020-04-16 | 5,000 | $18.00 | $90.0K | 0 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise deriv | 2020-04-08 | 2020-04-10 | 8,000 | — | $0 | 67,201 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2020-04-08 | 2020-04-10 | 8,000 | $15.01 | $120.1K | 0 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise | 2020-04-08 | 2020-04-10 | 8,000 | $4.56 | $36.5K | 8,000 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise deriv | 2020-04-01 | 2020-04-02 | 2,000 | — | $0 | 75,201 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2020-04-01 | 2020-04-02 | 2,000 | $15.21 | $30.4K | 0 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise | 2020-04-01 | 2020-04-02 | 2,000 | $4.56 | $9.1K | 2,000 | SEC↗ |
| Orwin John A | President & CEO | P Buy | 2020-03-17 | 2020-03-19 | 6,000 | $12.79 | $76.7K | 6,000 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise deriv | 2020-03-02 | 2020-03-04 | 15,000 | — | $0 | 77,201 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2020-03-02 | 2020-03-04 | 900 | $26.02 | $23.4K | 0 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2020-03-02 | 2020-03-04 | 3,341 | $24.03 | $80.3K | 5,947 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2020-03-02 | 2020-03-04 | 5,047 | $24.97 | $126.0K | 900 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise | 2020-03-02 | 2020-03-04 | 15,000 | $4.56 | $68.4K | 15,000 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2020-03-02 | 2020-03-04 | 5,712 | $22.98 | $131.3K | 9,288 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | A Award deriv | 2020-02-26 | 2020-02-28 | 88,000 | — | $0 | 88,000 | SEC↗ |
| Decker Lisa Lynn | Chief Business Officer | A Award deriv | 2020-02-26 | 2020-02-28 | 48,000 | — | $0 | 48,000 | SEC↗ |
| Courtney Phillips | General Counsel & Secretary | A Award deriv | 2020-02-26 | 2020-02-28 | 65,000 | — | $0 | 65,000 | SEC↗ |
| CROSS HERB | Chief Financial Officer | A Award deriv | 2020-02-26 | 2020-02-28 | 97,000 | — | $0 | 97,000 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | A Award deriv | 2020-02-26 | 2020-02-28 | 88,000 | — | $0 | 88,000 | SEC↗ |
| Orwin John A | President & CEO | A Award deriv | 2020-02-26 | 2020-02-28 | 241,000 | — | $0 | 241,000 | SEC↗ |
| Cavet Guy | Chief Technical Officer | M Exercise deriv | 2020-02-25 | 2020-02-26 | 2,100 | — | $0 | 14,566 | SEC↗ |
| Cavet Guy | Chief Technical Officer | S Sale | 2020-02-25 | 2020-02-26 | 6,197 | $20.53 | $127.2K | 88,661 | SEC↗ |
| Cavet Guy | Chief Technical Officer | S Sale | 2020-02-25 | 2020-02-26 | 903 | $21.39 | $19.3K | 87,758 | SEC↗ |
| Cavet Guy | Chief Technical Officer | M Exercise | 2020-02-25 | 2020-02-26 | 2,100 | $4.56 | $9.6K | 94,858 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise deriv | 2020-02-03 | 2020-02-04 | 15,000 | — | $0 | 92,201 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise | 2020-02-03 | 2020-02-04 | 15,000 | $4.56 | $68.4K | 15,000 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2020-02-03 | 2020-02-04 | 9,380 | $19.43 | $182.3K | 5,620 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2020-02-03 | 2020-02-04 | 5,620 | $20.02 | $112.5K | 0 | SEC↗ |
| Cavet Guy | Chief Technical Officer | S Sale | 2020-01-27 | 2020-01-29 | 10,000 | $20.00 | $200.0K | 92,758 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise deriv | 2020-01-24 | 2020-01-27 | 5,000 | — | $0 | 107,201 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2020-01-24 | 2020-01-27 | 5,000 | $18.47 | $92.3K | 0 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise | 2020-01-24 | 2020-01-27 | 5,000 | $4.56 | $22.8K | 5,000 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise deriv | 2020-01-17 | 2020-01-22 | 10,000 | — | $0 | 112,201 | SEC↗ |
| Cavet Guy | Chief Technical Officer | M Exercise deriv | 2020-01-17 | 2020-01-22 | 1,919 | — | $0 | 48,080 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2020-01-17 | 2020-01-22 | 908 | $15.57 | $14.1K | 0 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | S Sale | 2020-01-17 | 2020-01-22 | 9,092 | $14.83 | $134.8K | 9,092 | SEC↗ |
| Greenberg Norman Michael | Chief Scientific Officer | M Exercise | 2020-01-17 | 2020-01-22 | 10,000 | $4.56 | $45.6K | 10,000 | SEC↗ |
| Cavet Guy | Chief Technical Officer | S Sale | 2020-01-17 | 2020-01-22 | 6,395 | $14.84 | $94.9K | 103,282 | SEC↗ |
| Cavet Guy | Chief Technical Officer | S Sale | 2020-01-17 | 2020-01-22 | 524 | $15.59 | $8.2K | 102,758 | SEC↗ |
| Cavet Guy | Chief Technical Officer | M Exercise | 2020-01-17 | 2020-01-22 | 1,919 | $5.16 | $9.9K | 109,677 | SEC↗ |
| Rolfe Lindsey | Director | A Award deriv | 2019-08-22 | 2019-08-22 | 24,000 | — | $0 | 24,000 | SEC↗ |
| Courtney Phillips | General Counsel & Secretary | A Award deriv | 2019-07-11 | 2019-07-17 | 45,000 | — | $0 | 45,000 | SEC↗ |
| ATWOOD BRIAN G | Director | C Conversion deriv | 2019-06-24 | 2019-06-24 | 4,504 | — | $0 | 0 | SEC↗ |
| ATWOOD BRIAN G | Director | C Conversion deriv | 2019-06-24 | 2019-06-24 | 4,287 | — | $0 | 0 | SEC↗ |
| BERGER FRANKLIN M | Director | C Conversion deriv | 2019-06-24 | 2019-06-24 | 36,036 | — | $0 | 0 | SEC↗ |
| BERGER FRANKLIN M | Director | C Conversion deriv | 2019-06-24 | 2019-06-24 | 13,164 | — | $0 | 0 | SEC↗ |
| BERGER FRANKLIN M | Director | C Conversion deriv | 2019-06-24 | 2019-06-24 | 26,115 | — | $0 | 0 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | C Conversion deriv | 2019-06-24 | 2019-06-24 | 5,703 | — | $0 | 0 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | C Conversion deriv | 2019-06-24 | 2019-06-24 | 6,431 | — | $0 | 0 | SEC↗ |
| STEINMAN LAWRENCE | Director | C Conversion deriv | 2019-06-24 | 2019-06-24 | 8,405 | — | $0 | 0 | SEC↗ |
| Robinson William Hewitt | Director | C Conversion deriv | 2019-06-24 | 2019-06-24 | 5,703 | — | $0 | 0 | SEC↗ |
| Robinson William Hewitt | Director | C Conversion deriv | 2019-06-24 | 2019-06-24 | 4,287 | — | $0 | 0 | SEC↗ |
| Bill & Melinda Gates Foundatio | 10% Owner | C Conversion deriv | 2019-06-24 | 2019-06-24 | 1,396,644 | — | $0 | 0 | SEC↗ |
| Redmile Group, LLC | 10% Owner | C Conversion deriv | 2019-06-24 | 2019-06-24 | 715,306 | — | $0 | 0 | SEC↗ |
| Hadley Harbor Master Investors | 10% Owner | C Conversion deriv | 2019-06-24 | 2019-06-24 | 894,472 | — | $0 | 0 | SEC↗ |
| Hadley Harbor Master Investors | 10% Owner | C Conversion deriv | 2019-06-24 | 2019-06-24 | 1,039,783 | — | $0 | 0 | SEC↗ |
| BAKER BROS. ADVISORS LP | 10% Owner | C Conversion deriv | 2019-06-24 | 2019-06-26 | 394,084 | — | $0 | 0 | SEC↗ |
| BAKER BROS. ADVISORS LP | 10% Owner | P Buy deriv | 2019-06-24 | 2019-06-26 | 95,150 | $17.00 | $1.62M | 489,234 | SEC↗ |
| BAKER BROS. ADVISORS LP | 10% Owner | C Conversion deriv | 2019-06-24 | 2019-06-26 | 3,540,107 | — | $0 | 3,540,107 | SEC↗ |
| BAKER BROS. ADVISORS LP | 10% Owner | C Conversion deriv | 2019-06-24 | 2019-06-26 | 3,540,107 | — | $0 | 0 | SEC↗ |
| BAKER BROS. ADVISORS LP | 10% Owner | C Conversion deriv | 2019-06-24 | 2019-06-26 | 394,084 | — | $0 | 394,084 | SEC↗ |
| BAKER BROS. ADVISORS LP | 10% Owner | P Buy deriv | 2019-06-24 | 2019-06-26 | 1,904,850 | $17.00 | $32.38M | 5,444,957 | SEC↗ |
| BAKER BROS. ADVISORS LP | 10% Owner | C Conversion deriv | 2019-06-24 | 2019-06-26 | 219,852 | — | $0 | 0 | SEC↗ |
| BAKER BROS. ADVISORS LP | 10% Owner | C Conversion deriv | 2019-06-24 | 2019-06-26 | 2,302,669 | — | $0 | 0 | SEC↗ |
| BAKER BROS. ADVISORS LP | 10% Owner | C Conversion deriv | 2019-06-24 | 2019-06-26 | 89,878 | — | $0 | 0 | SEC↗ |
| BAKER BROS. ADVISORS LP | 10% Owner | C Conversion deriv | 2019-06-24 | 2019-06-26 | 920,361 | — | $0 | 0 | SEC↗ |
| ATWOOD BRIAN G | Director | C Conversion | 2019-06-24 | 2019-06-24 | 8,791 | — | $0 | 49,654 | SEC↗ |
| BERGER FRANKLIN M | Director | C Conversion | 2019-06-24 | 2019-06-24 | 75,315 | — | $0 | 97,808 | SEC↗ |
| Serafini Tito | Chief Strategy Officer | C Conversion | 2019-06-24 | 2019-06-24 | 12,134 | — | $0 | 480,820 | SEC↗ |
| STEINMAN LAWRENCE | Director | C Conversion | 2019-06-24 | 2019-06-24 | 8,405 | — | $0 | 258,405 | SEC↗ |
| Robinson William Hewitt | Director | C Conversion | 2019-06-24 | 2019-06-24 | 9,990 | — | $0 | 9,990 | SEC↗ |
| Bill & Melinda Gates Foundatio | 10% Owner | C Conversion | 2019-06-24 | 2019-06-24 | 1,396,644 | — | $0 | 1,396,644 | SEC↗ |
| Redmile Group, LLC | 10% Owner | C Conversion | 2019-06-24 | 2019-06-24 | 715,306 | — | $0 | 715,306 | SEC↗ |
| Hadley Harbor Master Investors | 10% Owner | C Conversion | 2019-06-24 | 2019-06-24 | 894,472 | — | $0 | 1,934,255 | SEC↗ |
| Hadley Harbor Master Investors | 10% Owner | C Conversion | 2019-06-24 | 2019-06-24 | 1,039,783 | — | $0 | 1,039,783 | SEC↗ |
| BAKER BROS. ADVISORS LP | 10% Owner | C Conversion | 2019-06-24 | 2019-06-26 | 3,223,030 | — | $0 | 3,223,030 | SEC↗ |
| BAKER BROS. ADVISORS LP | 10% Owner | C Conversion | 2019-06-24 | 2019-06-26 | 309,730 | — | $0 | 309,730 | SEC↗ |