Open-mkt buys · 90d
—
0 trades · 0 insiders
Open-mkt sales · 90d
—
0 trades · 0 insiders
Net · 90d
$0
Insiders on file
26
Daily buy vs sell · 90 days
No data yet.
Insiders
| Insider | Role | Trades | Bought | Sold | Last trade |
|---|---|---|---|---|---|
| FRIEDMAN PAUL A | Director | 7 | $0 | $0 | 2017-04-03 |
| GUIFFRE CHRISTOPHERD T | Sr. VP, Chief Business Officer | 10 | $0 | $0 | 2017-01-06 |
| Eliasof Scott | SVP, Chief Scientific Officer | 3 | $0 | $0 | 2017-01-05 |
| Carvajal Alejandra | VP, General Counsel | 5 | $0 | $0 | 2017-01-05 |
| Senderowicz Adrian | SVP, Chief Medical Officer | 6 | $0 | $0 | 2017-01-05 |
| ONeill James E | Principal Accounting Officer | 6 | $0 | $0 | 2017-01-05 |
| BELOFF GREGG | Interim CFO | 3 | $0 | $0 | 2017-01-05 |
| Arbuckle Stuart A | Director | 4 | $0 | $0 | 2017-01-03 |
| Parkinson David Ross | Director | 6 | $0 | $0 | 2017-01-03 |
| MCKEE WILLIAM | Director | 5 | $0 | $0 | 2017-01-03 |
| RASTETTER WILLIAM H | Director | 22 | $132.1K | $0 | 2017-01-03 |
| WALT DAVID R | Director | 42 | $436.1K | $0 | 2017-01-03 |
| Kelley Susan L. | Director | 4 | $0 | $0 | 2016-06-22 |
| Crane Alan L | Director, 10% Owner | 23 | $10.29M | $0 | 2016-06-22 |
| Hall Steven Edward | Director, 10% Owner | 10 | $5.13M | $0 | 2015-06-26 |
| CVF, LLC | 10% Owner | 8 | $7.79M | $0 | 2015-04-07 |
| Roberts Karen Lynn | Sr VP Finance & Administrat | 3 | $0 | $0 | 2015-02-05 |
| Garmey Edward Graeme | Sr. VP, Chief Medical Officer | 2 | $0 | $0 | 2015-02-05 |
| FETZER OLIVER | President and CEO | 3 | $0 | $0 | 2014-06-24 |
| LILLY ELI & CO | 10% Owner | 9 | $5.13M | $0 | 2014-04-15 |
| Rock Springs Capital Management LP | Other | 2 | $0 | $0 | 2014-04-15 |
| Lux Venture Associates II, LLC | Other | 17 | $743.6K | $0 | 2014-04-15 |
| Deer VII & Co. L.P. | Other | 2 | $0 | $0 | 2014-04-15 |
| Polaris Venture Partners Founders' Fund V, L.P. | 10% Owner | 13 | $10.29M | $0 | 2014-04-15 |
| VENROCK ASSOCIATES V LP | 10% Owner | 17 | $6.61M | $0 | 2014-04-15 |
| Polaris Venture Management Co IV LLC | 10% Owner | 12 | $0 | $0 | 2014-04-15 |
Trade history
| Insider | Role | Code | Trade | Filed | Shares | Price | Value | Owned after | |
|---|---|---|---|---|---|---|---|---|---|
| FRIEDMAN PAUL A | Director | A Award | 2017-04-03 | 2017-04-05 | 10,273 | $0.73 | $7.5K | 18,819 | SEC↗ |
| GUIFFRE CHRISTOPHERD T | Chief Executive Officer | A Award deriv | 2017-01-06 | 2017-01-09 | 150,000 | — | $0 | 150,000 | SEC↗ |
| GUIFFRE CHRISTOPHERD T | Chief Executive Officer | A Award deriv | 2017-01-06 | 2017-01-09 | 150,000 | — | $0 | 150,000 | SEC↗ |
| BELOFF GREGG | CFO | A Award deriv | 2017-01-05 | 2017-01-09 | 50,000 | — | $0 | 50,000 | SEC↗ |
| Carvajal Alejandra | VP, General Counsel | A Award deriv | 2017-01-05 | 2017-01-09 | 100,000 | — | $0 | 100,000 | SEC↗ |
| Carvajal Alejandra | VP, General Counsel | A Award deriv | 2017-01-05 | 2017-01-09 | 50,000 | — | $0 | 50,000 | SEC↗ |
| Eliasof Scott | SVP, Chief Scientific Office | A Award deriv | 2017-01-05 | 2017-01-09 | 100,000 | — | $0 | 100,000 | SEC↗ |
| Eliasof Scott | SVP, Chief Scientific Office | A Award deriv | 2017-01-05 | 2017-01-09 | 60,000 | — | $0 | 60,000 | SEC↗ |
| ONeill James E | Principal Accounting Officer | A Award deriv | 2017-01-05 | 2017-01-09 | 50,000 | — | $0 | 50,000 | SEC↗ |
| ONeill James E | Principal Accounting Officer | A Award deriv | 2017-01-05 | 2017-01-09 | 5,000 | — | $0 | 5,000 | SEC↗ |
| ONeill James E | Principal Accounting Officer | A Award deriv | 2017-01-05 | 2017-01-09 | 5,000 | — | $0 | 5,000 | SEC↗ |
| Senderowicz Adrian | SVP, Chief Medical Officer | A Award deriv | 2017-01-05 | 2017-01-09 | 150,000 | — | $0 | 150,000 | SEC↗ |
| Senderowicz Adrian | SVP, Chief Medical Officer | A Award deriv | 2017-01-05 | 2017-01-09 | 60,000 | — | $0 | 60,000 | SEC↗ |
| Arbuckle Stuart A | Director | A Award | 2017-01-03 | 2017-01-05 | 7,467 | $0.77 | $5.7K | 13,104 | SEC↗ |
| FRIEDMAN PAUL A | Director | A Award | 2017-01-03 | 2017-01-05 | 4,870 | $0.77 | $3.7K | 8,546 | SEC↗ |
| MCKEE WILLIAM | Director | A Award | 2017-01-03 | 2017-01-05 | 1,948 | $0.77 | $1.5K | 3,418 | SEC↗ |
| Parkinson David Ross | Director | A Award | 2017-01-03 | 2017-01-05 | 16,234 | $0.77 | $12.5K | 28,488 | SEC↗ |
| RASTETTER WILLIAM H | Director | A Award | 2017-01-03 | 2017-01-05 | 24,350 | $0.77 | $18.7K | 103,039 | SEC↗ |
| WALT DAVID R | Director | A Award | 2017-01-03 | 2017-01-05 | 14,935 | $0.77 | $11.5K | 193,700 | SEC↗ |
| GUIFFRE CHRISTOPHERD T | Chief Executive Officer | A Award | 2016-12-31 | 2017-01-05 | 5,733 | $0.60 | $3.4K | 12,489 | SEC↗ |
| Eliasof Scott | SVP, Chief Scientific Office | A Award deriv | 2016-10-25 | 2016-10-27 | 10,000 | — | $0 | 10,000 | SEC↗ |
| Arbuckle Stuart A | Director | A Award | 2016-10-03 | 2016-10-20 | 5,637 | $1.02 | $5.7K | 5,637 | SEC↗ |
| FRIEDMAN PAUL A | Director | A Award | 2016-10-03 | 2016-10-20 | 3,676 | $1.02 | $3.7K | 3,676 | SEC↗ |
| MCKEE WILLIAM | Director | A Award | 2016-10-03 | 2016-10-20 | 1,470 | $1.02 | $1.5K | 1,470 | SEC↗ |
| Parkinson David Ross | Director | A Award | 2016-10-03 | 2016-10-20 | 12,254 | $1.02 | $12.5K | 12,254 | SEC↗ |
| RASTETTER WILLIAM H | Director | A Award | 2016-10-03 | 2016-10-20 | 18,382 | $1.02 | $18.7K | 78,689 | SEC↗ |
| WALT DAVID R | Director | A Award | 2016-10-03 | 2016-10-20 | 11,274 | $1.02 | $11.5K | 178,765 | SEC↗ |
| Carvajal Alejandra | VP, General Counsel | A Award deriv | 2016-08-22 | 2016-08-23 | 75,000 | — | $0 | 75,000 | SEC↗ |
| BELOFF GREGG | CFO | A Award deriv | 2016-08-22 | 2016-08-23 | 75,000 | — | $0 | 75,000 | SEC↗ |
| ONeill James E | Principal Accounting Officer | A Award deriv | 2016-08-22 | 2016-08-23 | 50,000 | — | $0 | 50,000 | SEC↗ |
| Senderowicz Adrian | SVP, Chief Medical Officer | A Award deriv | 2016-08-22 | 2016-08-23 | 100,000 | — | $0 | 100,000 | SEC↗ |
| GUIFFRE CHRISTOPHERD T | Chief Executive Officer | A Award | 2016-06-30 | 2016-07-08 | 3,999 | $1.80 | $7.2K | 6,756 | SEC↗ |
| Arbuckle Stuart A | Director | A Award deriv | 2016-06-22 | 2016-06-24 | 20,000 | — | $0 | 20,000 | SEC↗ |
| Crane Alan L | Director, 10% Owner | A Award deriv | 2016-06-22 | 2016-06-24 | 20,000 | — | $0 | 20,000 | SEC↗ |
| FRIEDMAN PAUL A | Director | A Award deriv | 2016-06-22 | 2016-06-24 | 20,000 | — | $0 | 20,000 | SEC↗ |
| Kelley Susan L. | Director | A Award deriv | 2016-06-22 | 2016-06-24 | 20,000 | — | $0 | 20,000 | SEC↗ |
| MCKEE WILLIAM | Director | A Award deriv | 2016-06-22 | 2016-06-24 | 20,000 | — | $0 | 20,000 | SEC↗ |
| Parkinson David Ross | Director | A Award deriv | 2016-06-22 | 2016-06-24 | 20,000 | — | $0 | 20,000 | SEC↗ |
| RASTETTER WILLIAM H | Director | A Award deriv | 2016-06-22 | 2016-06-24 | 20,000 | — | $0 | 20,000 | SEC↗ |
| WALT DAVID R | Director | A Award deriv | 2016-06-22 | 2016-06-24 | 20,000 | — | $0 | 20,000 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-02-22 | 2016-02-23 | 591 | $2.09 | $1.2K | 167,491 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-02-19 | 2016-02-23 | 1,700 | $2.08 | $3.5K | 166,900 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-02-18 | 2016-02-19 | 4,500 | $2.09 | $9.4K | 165,200 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-02-17 | 2016-02-19 | 4,460 | $2.12 | $9.5K | 160,700 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-02-16 | 2016-02-17 | 4,500 | $2.00 | $9.0K | 156,240 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-02-12 | 2016-02-17 | 4,311 | $2.00 | $8.6K | 151,740 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-02-11 | 2016-02-12 | 4,350 | $2.03 | $8.8K | 147,429 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-02-10 | 2016-02-12 | 4,500 | $2.08 | $9.4K | 143,079 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-02-09 | 2016-02-10 | 4,500 | $2.08 | $9.4K | 138,579 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-02-08 | 2016-02-10 | 4,500 | $2.22 | $10.0K | 134,079 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-02-05 | 2016-02-08 | 4,500 | $2.29 | $10.3K | 129,579 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-02-04 | 2016-02-08 | 4,063 | $2.31 | $9.4K | 125,079 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-02-03 | 2016-02-04 | 4,018 | $2.27 | $9.1K | 121,016 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-02-02 | 2016-02-04 | 4,395 | $2.37 | $10.4K | 116,998 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-02-01 | 2016-02-02 | 4,500 | $2.37 | $10.7K | 112,603 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-01-29 | 2016-02-02 | 1,200 | $2.41 | $2.9K | 108,103 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-01-28 | 2016-01-29 | 4,500 | $2.45 | $11.0K | 106,903 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-01-27 | 2016-01-29 | 4,500 | $2.47 | $11.1K | 102,403 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-01-26 | 2016-01-27 | 4,300 | $2.44 | $10.5K | 97,903 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-01-25 | 2016-01-27 | 4,500 | $2.35 | $10.6K | 93,603 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-01-22 | 2016-01-25 | 4,500 | $2.24 | $10.1K | 89,103 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-01-21 | 2016-01-25 | 4,500 | $2.32 | $10.4K | 84,603 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-01-20 | 2016-01-21 | 4,500 | $2.35 | $10.6K | 80,103 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-01-19 | 2016-01-21 | 4,400 | $2.52 | $11.1K | 75,603 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-01-15 | 2016-01-19 | 4,172 | $2.42 | $10.1K | 71,203 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-01-14 | 2016-01-19 | 4,400 | $2.64 | $11.6K | 67,031 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-01-13 | 2016-01-14 | 4,384 | $2.69 | $11.8K | 62,631 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-01-12 | 2016-01-14 | 4,300 | $2.89 | $12.4K | 58,247 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-01-11 | 2016-01-12 | 4,355 | $2.86 | $12.5K | 53,947 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-01-08 | 2016-01-12 | 4,500 | $2.87 | $12.9K | 49,592 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-01-07 | 2016-01-08 | 4,300 | $2.87 | $12.3K | 45,092 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-01-06 | 2016-01-08 | 4,500 | $3.03 | $13.6K | 40,792 | SEC↗ |
| ONeill James E | Principal Accounting Officer | A Award deriv | 2016-01-05 | 2016-05-27 | 4,900 | — | $0 | 4,900 | SEC↗ |
| Carvajal Alejandra | VP, General Counsel | A Award deriv | 2016-01-05 | 2016-01-07 | 45,000 | — | $0 | 45,000 | SEC↗ |
| Senderowicz Adrian | SVP, Chief Medical Officer | A Award deriv | 2016-01-05 | 2016-01-07 | 50,000 | — | $0 | 50,000 | SEC↗ |
| GUIFFRE CHRISTOPHERD T | Chief Executive Officer | A Award deriv | 2016-01-05 | 2016-01-07 | 137,000 | — | $0 | 137,000 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-01-05 | 2016-01-06 | 4,301 | $3.06 | $13.2K | 36,292 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2016-01-04 | 2016-01-06 | 4,500 | $3.01 | $13.5K | 31,991 | SEC↗ |
| ONeill James E | Principal Accounting Officer | A Award | 2015-12-31 | 2016-05-27 | 1,098 | $2.38 | $2.6K | 2,098 | SEC↗ |
| GUIFFRE CHRISTOPHERD T | Chief Executive Officer | A Award | 2015-12-31 | 2016-01-07 | 2,757 | $2.38 | $6.6K | 2,757 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2015-12-03 | 2015-12-07 | 10,000 | $3.75 | $37.5K | 27,491 | SEC↗ |
| Carvajal Alejandra | VP, General Counsel | A Award deriv | 2015-12-01 | 2015-12-03 | 158,000 | — | $0 | 158,000 | SEC↗ |
| Senderowicz Adrian | SVP, Chief Medical Officer | A Award deriv | 2015-12-01 | 2015-12-03 | 158,000 | — | $0 | 158,000 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2015-11-30 | 2015-12-02 | 5,374 | $3.25 | $17.5K | 17,491 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2015-11-27 | 2015-11-30 | 6,700 | $3.28 | $22.0K | 12,117 | SEC↗ |
| WALT DAVID R | Director | P Buy | 2015-11-25 | 2015-11-30 | 5,417 | $3.37 | $18.3K | 5,417 | SEC↗ |
| WALT DAVID R | Director | A Award deriv | 2015-09-23 | 2015-09-25 | 22,000 | — | $0 | 22,000 | SEC↗ |
| Senderowicz Adrian | SVP, Chief Medical Officer | A Award deriv | 2015-09-04 | 2015-12-03 | 135,000 | — | $0 | 135,000 | SEC↗ |
| Arbuckle Stuart A | Director | A Award deriv | 2015-06-26 | 2015-06-30 | 22,000 | — | $0 | 22,000 | SEC↗ |
| Crane Alan L | Director, 10% Owner | A Award deriv | 2015-06-26 | 2015-06-30 | 11,000 | — | $0 | 11,000 | SEC↗ |
| FRIEDMAN PAUL A | Director | A Award deriv | 2015-06-26 | 2015-06-30 | 8,214 | — | $0 | 8,214 | SEC↗ |
| FRIEDMAN PAUL A | Director | A Award deriv | 2015-06-26 | 2015-06-30 | 11,000 | — | $0 | 11,000 | SEC↗ |
| Hall Steven Edward | Director, 10% Owner | A Award deriv | 2015-06-26 | 2015-06-30 | 11,000 | — | $0 | 11,000 | SEC↗ |
| Kelley Susan L. | Director | A Award deriv | 2015-06-26 | 2015-06-30 | 7,000 | — | $0 | 7,000 | SEC↗ |
| Kelley Susan L. | Director | A Award deriv | 2015-06-26 | 2015-06-30 | 11,000 | — | $0 | 11,000 | SEC↗ |
| MCKEE WILLIAM | Director | A Award deriv | 2015-06-26 | 2015-06-30 | 8,214 | — | $0 | 8,214 | SEC↗ |
| MCKEE WILLIAM | Director | A Award deriv | 2015-06-26 | 2015-06-30 | 11,000 | — | $0 | 11,000 | SEC↗ |
| Parkinson David Ross | Director | A Award deriv | 2015-06-26 | 2015-06-30 | 11,000 | — | $0 | 11,000 | SEC↗ |
| Parkinson David Ross | Director | A Award deriv | 2015-06-26 | 2015-06-30 | 7,000 | — | $0 | 7,000 | SEC↗ |
| RASTETTER WILLIAM H | Director | A Award deriv | 2015-06-26 | 2015-06-30 | 8,214 | — | $0 | 8,214 | SEC↗ |
| RASTETTER WILLIAM H | Director | A Award deriv | 2015-06-26 | 2015-06-30 | 11,000 | — | $0 | 11,000 | SEC↗ |
| BELOFF GREGG | Interim CFO | A Award deriv | 2015-05-27 | 2015-05-29 | 90,000 | — | $0 | 90,000 | SEC↗ |
| CVF, LLC | 10% Owner | P Buy | 2015-04-07 | 2015-04-09 | 333,333 | $6.00 | $2.00M | 2,592,577 | SEC↗ |
| GUIFFRE CHRISTOPHERD T | Chief Executive Officer | A Award deriv | 2015-03-23 | 2015-03-25 | 407,520 | — | $0 | 407,520 | SEC↗ |
| Garmey Edward Graeme | Sr. VP, Chief Medical Office | A Award deriv | 2015-02-05 | 2015-02-09 | 43,000 | — | $0 | 166,586 | SEC↗ |
| Roberts Karen Lynn | Sr VP Finance & Administrat | A Award deriv | 2015-02-05 | 2015-02-09 | 43,000 | — | $0 | 163,774 | SEC↗ |
| GUIFFRE CHRISTOPHERD T | Chief Operating Officer | A Award deriv | 2015-02-05 | 2015-02-09 | 75,000 | — | $0 | 317,457 | SEC↗ |
| Parkinson David Ross | Director | A Award deriv | 2014-10-29 | 2014-10-31 | 15,000 | — | $0 | 15,000 | SEC↗ |
| FRIEDMAN PAUL A | Director | A Award deriv | 2014-10-29 | 2014-10-31 | 100,000 | — | $0 | 113,786 | SEC↗ |
| GUIFFRE CHRISTOPHERD T | Chief Operating Officer | A Award deriv | 2014-10-29 | 2014-10-31 | 50,300 | — | $0 | 242,457 | SEC↗ |
| Kelley Susan L. | Director | A Award deriv | 2014-10-03 | 2014-10-07 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Crane Alan L | Director, 10% Owner | A Award deriv | 2014-09-16 | 2014-09-16 | 16,000 | — | $0 | 16,000 | SEC↗ |
| Crane Alan L | Director, 10% Owner | D To issuer deriv | 2014-09-16 | 2014-09-16 | 35,765 | — | $0 | 0 | SEC↗ |
| Roberts Karen Lynn | Sr VP Finance & Administrat | A Award deriv | 2014-07-17 | 2014-07-18 | 20,100 | — | $0 | 120,774 | SEC↗ |
| Roberts Karen Lynn | Sr VP Finance & Administrat | A Award deriv | 2014-06-24 | 2014-06-26 | 38,200 | — | $0 | 100,674 | SEC↗ |
| Garmey Edward Graeme | Sr. VP, Chief Medical Office | A Award deriv | 2014-06-24 | 2014-06-26 | 50,300 | — | $0 | 123,586 | SEC↗ |
| GUIFFRE CHRISTOPHERD T | Sr. VP, Chief Business Offic | A Award deriv | 2014-06-24 | 2014-06-26 | 50,300 | — | $0 | 192,158 | SEC↗ |
| FETZER OLIVER | President and CEO | A Award deriv | 2014-06-24 | 2014-06-26 | 290,000 | — | $0 | 730,569 | SEC↗ |
| FETZER OLIVER | President and CEO | M Exercise deriv | 2014-05-16 | 2014-05-19 | 30,000 | — | $0 | 102,215 | SEC↗ |
| FETZER OLIVER | President and CEO | M Exercise | 2014-05-16 | 2014-05-19 | 30,000 | $3.34 | $100.2K | 30,000 | SEC↗ |
| Deer VII & Co. L.P. | Other | J Other deriv | 2014-04-15 | 2014-04-15 | 27,672 | — | $0 | 0 | SEC↗ |
| Deer VII & Co. L.P. | Other | J Other deriv | 2014-04-15 | 2014-04-15 | 1,907 | — | $0 | 1,907 | SEC↗ |
| Rock Springs Capital Managemen | Other | C Conversion deriv | 2014-04-15 | 2014-04-15 | 0 | — | $0 | 0 | SEC↗ |
| Lux Venture Associates II, LLC | Other | C Conversion deriv | 2014-04-15 | 2014-04-15 | 706,026 | — | $0 | 0 | SEC↗ |
| Lux Venture Associates II, LLC | Other | C Conversion deriv | 2014-04-15 | 2014-04-15 | 2,488,436 | — | $0 | 0 | SEC↗ |
| Lux Venture Associates II, LLC | Other | C Conversion deriv | 2014-04-15 | 2014-04-15 | 2,675,534 | — | $0 | 0 | SEC↗ |
| Lux Venture Associates II, LLC | Other | C Conversion deriv | 2014-04-15 | 2014-04-15 | 707,000 | — | $0 | 0 | SEC↗ |
| Lux Venture Associates II, LLC | Other | J Other deriv | 2014-04-15 | 2014-04-15 | 124,220 | — | $0 | 0 | SEC↗ |
| Lux Venture Associates II, LLC | Other | C Conversion deriv | 2014-04-15 | 2014-04-15 | 1,538,461 | — | $0 | 0 | SEC↗ |
| Lux Venture Associates II, LLC | Other | J Other deriv | 2014-04-15 | 2014-04-15 | 8,561 | — | $0 | 8,561 | SEC↗ |
| Lux Venture Associates II, LLC | Other | C Conversion deriv | 2014-04-15 | 2014-04-15 | 0 | — | $0 | 0 | SEC↗ |
| Lux Venture Associates II, LLC | Other | C Conversion deriv | 2014-04-15 | 2014-04-15 | 0 | — | $0 | 0 | SEC↗ |
| Hall Steven Edward | Director, 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 4,340,831 | — | $0 | 0 | SEC↗ |
| Hall Steven Edward | Director, 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 0 | — | $0 | 0 | SEC↗ |
| Hall Steven Edward | Director, 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 0 | — | $0 | 0 | SEC↗ |
| Hall Steven Edward | Director, 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 13,513,513 | — | $0 | 0 | SEC↗ |
| LILLY ELI & CO | 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 13,513,513 | — | $0 | 0 | SEC↗ |
| LILLY ELI & CO | 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 0 | — | $0 | 0 | SEC↗ |
| LILLY ELI & CO | 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 0 | — | $0 | 0 | SEC↗ |
| LILLY ELI & CO | 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 4,340,831 | — | $0 | 0 | SEC↗ |
| Crane Alan L | Director, 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 30,432 | — | $0 | 0 | SEC↗ |
| Crane Alan L | Director, 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 8,598,139 | — | $0 | 0 | SEC↗ |
| Crane Alan L | Director, 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 9,509,913 | — | $0 | 0 | SEC↗ |
| Crane Alan L | Director, 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 2,513,500 | — | $0 | 0 | SEC↗ |
| Crane Alan L | Director, 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 1,631,107 | — | $0 | 0 | SEC↗ |
| Crane Alan L | Director, 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 3,846,154 | — | $0 | 0 | SEC↗ |
| Crane Alan L | Director, 10% Owner | J Other deriv | 2014-04-15 | 2014-04-15 | 0 | — | $0 | 0 | SEC↗ |
| Crane Alan L | Director, 10% Owner | J Other deriv | 2014-04-15 | 2014-04-15 | 0 | — | $0 | 30,432 | SEC↗ |
| Crane Alan L | Director, 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 2,500,000 | — | $0 | 0 | SEC↗ |
| Crane Alan L | Director, 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 441,528 | — | $0 | 0 | SEC↗ |
| Polaris Venture Management Co | 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 2,631,574 | — | $0 | 0 | SEC↗ |
| Polaris Venture Management Co | 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 5,154,654 | — | $0 | 0 | SEC↗ |
| Polaris Venture Management Co | 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 2,673,938 | — | $0 | 0 | SEC↗ |
| Polaris Venture Management Co | 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 3,084,615 | — | $0 | 0 | SEC↗ |
| Polaris Venture Management Co | 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 7,231,419 | — | $0 | 0 | SEC↗ |
| Polaris Venture Management Co | 10% Owner | J Other deriv | 2014-04-15 | 2014-04-15 | 77,478 | — | $0 | 0 | SEC↗ |
| Polaris Venture Management Co | 10% Owner | J Other deriv | 2014-04-15 | 2014-04-15 | 5,340 | — | $0 | 5,340 | SEC↗ |
| Polaris Venture Partners Found | 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 2,698,039 | — | $0 | 0 | SEC↗ |
| Polaris Venture Partners Found | 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 25,092 | — | $0 | 0 | SEC↗ |
| Polaris Venture Partners Found | 10% Owner | J Other deriv | 2014-04-15 | 2014-04-15 | 0 | — | $0 | 0 | SEC↗ |
| Polaris Venture Partners Found | 10% Owner | J Other deriv | 2014-04-15 | 2014-04-15 | 0 | — | $0 | 25,092 | SEC↗ |
| Polaris Venture Partners Found | 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 6,793,234 | — | $0 | 0 | SEC↗ |
| Polaris Venture Partners Found | 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 2,278,494 | — | $0 | 0 | SEC↗ |
| Polaris Venture Partners Found | 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-15 | 5,513,524 | — | $0 | 0 | SEC↗ |
| CVF, LLC | 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-16 | 12,048,192 | — | $0 | 0 | SEC↗ |
| CVF, LLC | 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-16 | 3,139,808 | — | $0 | 0 | SEC↗ |
| CVF, LLC | 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-16 | 828,747 | — | $0 | 0 | SEC↗ |
| RASTETTER WILLIAM H | Director | C Conversion deriv | 2014-04-15 | 2014-04-17 | 380 | — | $0 | 0 | SEC↗ |
| RASTETTER WILLIAM H | Director | C Conversion deriv | 2014-04-15 | 2014-04-17 | 5,522 | — | $0 | 0 | SEC↗ |
| RASTETTER WILLIAM H | Director | C Conversion deriv | 2014-04-15 | 2014-04-17 | 110,107 | — | $0 | 0 | SEC↗ |
| RASTETTER WILLIAM H | Director | C Conversion deriv | 2014-04-15 | 2014-04-17 | 118,954 | — | $0 | 0 | SEC↗ |
| RASTETTER WILLIAM H | Director | C Conversion deriv | 2014-04-15 | 2014-04-17 | 31,500 | — | $0 | 0 | SEC↗ |
| RASTETTER WILLIAM H | Director | C Conversion deriv | 2014-04-15 | 2014-04-17 | 22,801 | — | $0 | 0 | SEC↗ |
| RASTETTER WILLIAM H | Director | C Conversion deriv | 2014-04-15 | 2014-04-17 | 76,923 | — | $0 | 0 | SEC↗ |
| RASTETTER WILLIAM H | Director | J Other deriv | 2014-04-15 | 2014-04-17 | 0 | — | $0 | 380 | SEC↗ |
| RASTETTER WILLIAM H | Director | J Other deriv | 2014-04-15 | 2014-04-17 | 0 | — | $0 | 0 | SEC↗ |
| VENROCK ASSOCIATES V LP | 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-17 | 4,245,941 | — | $0 | 0 | SEC↗ |
| VENROCK ASSOCIATES V LP | 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-17 | 0 | — | $0 | 0 | SEC↗ |
| VENROCK ASSOCIATES V LP | 10% Owner | J Other deriv | 2014-04-15 | 2014-04-17 | 19,022 | — | $0 | 19,022 | SEC↗ |
| VENROCK ASSOCIATES V LP | 10% Owner | J Other deriv | 2014-04-15 | 2014-04-17 | 275,977 | — | $0 | 0 | SEC↗ |
| VENROCK ASSOCIATES V LP | 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-17 | 5,500,704 | — | $0 | 0 | SEC↗ |
| VENROCK ASSOCIATES V LP | 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-17 | 5,944,145 | — | $0 | 0 | SEC↗ |
| VENROCK ASSOCIATES V LP | 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-17 | 1,868,955 | — | $0 | 0 | SEC↗ |
| VENROCK ASSOCIATES V LP | 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-17 | 5,154,653 | — | $0 | 0 | SEC↗ |
| VENROCK ASSOCIATES V LP | 10% Owner | C Conversion deriv | 2014-04-15 | 2014-04-17 | 0 | — | $0 | 0 | SEC↗ |
| Rock Springs Capital Managemen | Other | C Conversion | 2014-04-15 | 2014-04-15 | 464,365 | — | $0 | 464,365 | SEC↗ |
| Lux Venture Associates II, LLC | Other | C Conversion | 2014-04-15 | 2014-04-15 | 184,422 | — | $0 | 538,037 | SEC↗ |
| Lux Venture Associates II, LLC | Other | C Conversion | 2014-04-15 | 2014-04-15 | 171,525 | — | $0 | 709,562 | SEC↗ |
| Lux Venture Associates II, LLC | Other | C Conversion | 2014-04-15 | 2014-04-15 | 37,378 | — | $0 | 746,940 | SEC↗ |
| Lux Venture Associates II, LLC | Other | C Conversion | 2014-04-15 | 2014-04-15 | 98,835 | — | $0 | 845,775 | SEC↗ |
| Lux Venture Associates II, LLC | Other | P Buy | 2014-04-15 | 2014-04-15 | 106,224 | $7.00 | $743.6K | 951,999 | SEC↗ |
| Lux Venture Associates II, LLC | Other | C Conversion | 2014-04-15 | 2014-04-15 | 79,780 | — | $0 | 221,902 | SEC↗ |
| Lux Venture Associates II, LLC | Other | C Conversion | 2014-04-15 | 2014-04-15 | 142,122 | — | $0 | 142,122 | SEC↗ |
| Lux Venture Associates II, LLC | Other | C Conversion | 2014-04-15 | 2014-04-15 | 131,713 | — | $0 | 353,615 | SEC↗ |
| Hall Steven Edward | Director, 10% Owner | P Buy | 2014-04-15 | 2014-04-15 | 733,445 | $7.00 | $5.13M | 2,356,227 | SEC↗ |
| Hall Steven Edward | Director, 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 199,875 | — | $0 | 1,622,782 | SEC↗ |
| Hall Steven Edward | Director, 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 931,485 | — | $0 | 931,485 | SEC↗ |
| Hall Steven Edward | Director, 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 192,209 | — | $0 | 1,422,907 | SEC↗ |
| Hall Steven Edward | Director, 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 299,213 | — | $0 | 1,230,698 | SEC↗ |
| LILLY ELI & CO | 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 192,209 | — | $0 | 1,422,907 | SEC↗ |
| LILLY ELI & CO | 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 299,213 | — | $0 | 1,230,698 | SEC↗ |
| LILLY ELI & CO | 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 199,875 | — | $0 | 1,622,782 | SEC↗ |
| LILLY ELI & CO | 10% Owner | P Buy | 2014-04-15 | 2014-04-15 | 733,445 | $7.00 | $5.13M | 2,356,227 | SEC↗ |
| LILLY ELI & CO | 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 931,485 | — | $0 | 931,485 | SEC↗ |
| Crane Alan L | Director, 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 468,263 | — | $0 | 1,266,484 | SEC↗ |
| Crane Alan L | Director, 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 184,314 | — | $0 | 798,221 | SEC↗ |
| Crane Alan L | Director, 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 355,307 | — | $0 | 613,907 | SEC↗ |
| Crane Alan L | Director, 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 181,399 | — | $0 | 258,600 | SEC↗ |
| Crane Alan L | Director, 10% Owner | P Buy | 2014-04-15 | 2014-04-15 | 1,470,582 | $7.00 | $10.29M | 4,771,739 | SEC↗ |
| Crane Alan L | Director, 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 401,061 | — | $0 | 3,301,157 | SEC↗ |
| Crane Alan L | Director, 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 385,435 | — | $0 | 2,900,096 | SEC↗ |
| Crane Alan L | Director, 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 592,665 | — | $0 | 2,514,661 | SEC↗ |
| Crane Alan L | Director, 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 655,512 | — | $0 | 1,921,996 | SEC↗ |
| Polaris Venture Management Co | 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 212,621 | — | $0 | 1,432,101 | SEC↗ |
| Polaris Venture Management Co | 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 498,460 | — | $0 | 1,219,480 | SEC↗ |
| Polaris Venture Management Co | 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 181,399 | — | $0 | 181,399 | SEC↗ |
| Polaris Venture Management Co | 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 355,307 | — | $0 | 536,706 | SEC↗ |
| Polaris Venture Management Co | 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 184,314 | — | $0 | 721,020 | SEC↗ |
| Polaris Venture Partners Found | 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 401,061 | — | $0 | 1,791,855 | SEC↗ |
| Polaris Venture Partners Found | 10% Owner | P Buy | 2014-04-15 | 2014-04-15 | 1,470,582 | $7.00 | $10.29M | 3,262,437 | SEC↗ |
| Polaris Venture Partners Found | 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 468,263 | — | $0 | 468,263 | SEC↗ |
| Polaris Venture Partners Found | 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 157,052 | — | $0 | 625,315 | SEC↗ |
| Polaris Venture Partners Found | 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 385,435 | — | $0 | 1,390,794 | SEC↗ |
| Polaris Venture Partners Found | 10% Owner | C Conversion | 2014-04-15 | 2014-04-15 | 380,044 | — | $0 | 1,005,359 | SEC↗ |
| CVF, LLC | 10% Owner | C Conversion | 2014-04-15 | 2014-04-16 | 448,544 | — | $0 | 1,279,024 | SEC↗ |
| CVF, LLC | 10% Owner | C Conversion | 2014-04-15 | 2014-04-16 | 830,480 | — | $0 | 830,480 | SEC↗ |
| CVF, LLC | 10% Owner | C Conversion | 2014-04-15 | 2014-04-16 | 152,764 | — | $0 | 1,431,788 | SEC↗ |
| CVF, LLC | 10% Owner | P Buy | 2014-04-15 | 2014-04-16 | 827,456 | $7.00 | $5.79M | 2,259,244 | SEC↗ |
| RASTETTER WILLIAM H | Director | C Conversion | 2014-04-15 | 2014-04-17 | 5,146 | — | $0 | 41,438 | SEC↗ |
| RASTETTER WILLIAM H | Director | P Buy | 2014-04-15 | 2014-04-17 | 18,869 | $7.00 | $132.1K | 60,307 | SEC↗ |
| RASTETTER WILLIAM H | Director | C Conversion | 2014-04-15 | 2014-04-17 | 8,199 | — | $0 | 23,749 | SEC↗ |
| RASTETTER WILLIAM H | Director | C Conversion | 2014-04-15 | 2014-04-17 | 2,576 | — | $0 | 9,682 | SEC↗ |
| RASTETTER WILLIAM H | Director | C Conversion | 2014-04-15 | 2014-04-17 | 7,106 | — | $0 | 7,106 | SEC↗ |
| RASTETTER WILLIAM H | Director | C Conversion | 2014-04-15 | 2014-04-17 | 5,868 | — | $0 | 15,550 | SEC↗ |
| RASTETTER WILLIAM H | Director | C Conversion | 2014-04-15 | 2014-04-17 | 7,589 | — | $0 | 31,338 | SEC↗ |
| RASTETTER WILLIAM H | Director | C Conversion | 2014-04-15 | 2014-04-17 | 4,954 | — | $0 | 36,292 | SEC↗ |
| VENROCK ASSOCIATES V LP | 10% Owner | C Conversion | 2014-04-15 | 2014-04-17 | 128,827 | — | $0 | 484,134 | SEC↗ |
| VENROCK ASSOCIATES V LP | 10% Owner | C Conversion | 2014-04-15 | 2014-04-17 | 355,307 | — | $0 | 355,307 | SEC↗ |
| VENROCK ASSOCIATES V LP | 10% Owner | C Conversion | 2014-04-15 | 2014-04-17 | 257,529 | — | $0 | 2,070,727 | SEC↗ |
| VENROCK ASSOCIATES V LP | 10% Owner | C Conversion | 2014-04-15 | 2014-04-17 | 247,501 | — | $0 | 1,813,198 | SEC↗ |
| VENROCK ASSOCIATES V LP | 10% Owner | C Conversion | 2014-04-15 | 2014-04-17 | 379,160 | — | $0 | 1,565,697 | SEC↗ |
| VENROCK ASSOCIATES V LP | 10% Owner | C Conversion | 2014-04-15 | 2014-04-17 | 409,728 | — | $0 | 1,186,537 | SEC↗ |
| VENROCK ASSOCIATES V LP | 10% Owner | C Conversion | 2014-04-15 | 2014-04-17 | 292,675 | — | $0 | 776,809 | SEC↗ |
| VENROCK ASSOCIATES V LP | 10% Owner | P Buy | 2014-04-15 | 2014-04-17 | 944,290 | $7.00 | $6.61M | 3,015,017 | SEC↗ |