Open-mkt buys · 90d
—
0 trades · 0 insiders
Open-mkt sales · 90d
—
0 trades · 0 insiders
Net · 90d
$0
Insiders on file
24
Daily buy vs sell · 90 days
No data yet.
Insiders
| Insider | Role | Trades | Bought | Sold | Last trade |
|---|---|---|---|---|---|
| Moore David Scott | Director | 3 | $250.2K | $0 | 2026-06-11 |
| van den Broek Richard | Director | 2 | $0 | $0 | 2026-06-11 |
| Grais Linda S | Director | 14 | $24.5K | $0 | 2026-06-11 |
| Thompson Peter A. | Director, 10% Owner | 71 | $24.73M | $11.65M | 2026-06-11 |
| CLARK IAN T | Director | 15 | $0 | $0 | 2026-06-11 |
| MILLER RICHARD A MD | President and CEO | 64 | $3.54M | $0 | 2026-05-18 |
| Chan Andrew C. | Director | 1 | $0 | $0 | 2026-04-23 |
| LEA LEIV | Chief Financial Officer | 20 | $294.1K | $0 | 2025-12-04 |
| Arcara Jeffrey | Chief Business Officer | 3 | $0 | $0 | 2025-12-04 |
| Jones William Benton | VP Pharmaceutical Development | 16 | $50.4K | $0 | 2025-12-04 |
| ORBIMED ADVISORS LLC | Director, 10% Owner | 21 | $21.00M | $4.89M | 2025-06-27 |
| Morrison Scott W | Director | 13 | $0 | $0 | 2025-06-12 |
| Gould Terry P | Director, 10% Owner | 38 | $8.00M | $0 | 2024-06-13 |
| OrbiMed Capital GP V LLC | Director, 10% Owner | 9 | $3.74M | $6.76M | 2024-05-06 |
| Mitchell Edith P. | Director | 7 | $0 | $0 | 2023-12-06 |
| ADAMS STREET PARTNERS LLC | 10% Owner | 34 | $8.00M | $0 | 2022-08-11 |
| EcoR1 Capital, LLC | 10% Owner | 2 | $0 | $25.04M | 2021-10-01 |
| Mobasher Mehrdad | VP, Chief Medical Officer | 3 | $0 | $0 | 2020-12-16 |
| Novo Holdings A/S | 10% Owner | 13 | $20.92M | $14.24M | 2020-07-08 |
| Krognes Steve E. | Director, 10% Owner | 6 | $0 | $0 | 2020-06-09 |
| Hunt Daniel W. | SVP, Chief Business Officer | 3 | $0 | $0 | 2019-12-12 |
| Verner Erik J. | VP, Chemistry Research | 5 | $0 | $0 | 2019-12-12 |
| Buggy Joseph J | EVP, Discovery Research | 3 | $0 | $0 | 2019-12-12 |
| Coloma Jason V | SVP, Chief Business Officer | 1 | $0 | $0 | 2016-06-08 |
Trade history
| Insider | Role | Code | Trade | Filed | Shares | Price | Value | Owned after | |
|---|---|---|---|---|---|---|---|---|---|
| van den Broek Richard | Director | A Award deriv | 2026-06-11 | 2026-06-15 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | A Award deriv | 2026-06-11 | 2026-06-15 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Grais Linda | Director | A Award deriv | 2026-06-11 | 2026-06-15 | 15,000 | — | $0 | 15,000 | SEC↗ |
| CLARK IAN T | Director | A Award deriv | 2026-06-11 | 2026-06-15 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Moore David Scott | Director | A Award deriv | 2026-06-11 | 2026-06-15 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Moore David Scott | Director | P Buy | 2026-06-11 | 2026-06-15 | 21,700 | $11.53 | $250.2K | 21,700 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2026-05-18 | 2026-05-20 | 1,932 | $12.01 | $23.2K | 1,195,035 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2026-05-18 | 2026-05-20 | 5,000 | $12.05 | $60.3K | 1,193,103 | SEC↗ |
| Chan Andrew C. | Director | A Award deriv | 2026-04-23 | 2026-04-27 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise deriv | 2026-01-28 | 2026-01-30 | 15,000 | — | $0 | 0 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise deriv | 2026-01-28 | 2026-01-30 | 15,000 | — | $0 | 0 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise deriv | 2026-01-28 | 2026-01-30 | 15,000 | — | $0 | 0 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise deriv | 2026-01-28 | 2026-01-30 | 15,000 | — | $0 | 0 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise deriv | 2026-01-28 | 2026-01-30 | 15,000 | — | $0 | 0 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise deriv | 2026-01-28 | 2026-01-30 | 15,000 | — | $0 | 0 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise deriv | 2026-01-28 | 2026-01-30 | 30,000 | — | $0 | 0 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise deriv | 2026-01-28 | 2026-01-30 | 15,000 | — | $0 | 0 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise deriv | 2026-01-28 | 2026-01-30 | 15,000 | — | $0 | 0 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise deriv | 2026-01-28 | 2026-01-30 | 15,000 | — | $0 | 0 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise deriv | 2026-01-28 | 2026-01-30 | 15,000 | — | $0 | 0 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise deriv | 2026-01-28 | 2026-01-30 | 15,000 | — | $0 | 0 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise deriv | 2026-01-28 | 2026-01-30 | 15,000 | — | $0 | 0 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise | 2026-01-28 | 2026-01-30 | 15,000 | $2.74 | $41.1K | 120,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise | 2026-01-28 | 2026-01-30 | 15,000 | $1.64 | $24.6K | 195,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise | 2026-01-28 | 2026-01-30 | 15,000 | $2.49 | $37.4K | 180,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise | 2026-01-28 | 2026-01-30 | 15,000 | $0.97 | $14.6K | 165,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise | 2026-01-28 | 2026-01-30 | 15,000 | $0.99 | $14.8K | 150,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise | 2026-01-28 | 2026-01-30 | 15,000 | $2.60 | $39.0K | 135,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise | 2026-01-28 | 2026-01-30 | 15,000 | $2.12 | $31.8K | 210,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise | 2026-01-28 | 2026-01-30 | 15,000 | $3.27 | $49.0K | 105,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise | 2026-01-28 | 2026-01-30 | 15,000 | $2.00 | $30.0K | 90,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise | 2026-01-28 | 2026-01-30 | 15,000 | $3.61 | $54.1K | 75,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise | 2026-01-28 | 2026-01-30 | 15,000 | $12.50 | $187.5K | 60,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise | 2026-01-28 | 2026-01-30 | 15,000 | $9.70 | $145.5K | 45,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | M Exercise | 2026-01-28 | 2026-01-30 | 30,000 | $15.00 | $450.0K | 30,000 | SEC↗ |
| LEA LEIV | Chief Financial Officer | A Award deriv | 2025-12-04 | 2025-12-08 | 400,000 | — | $0 | 400,000 | SEC↗ |
| Arcara Jeffrey | Chief Business Officer | A Award deriv | 2025-12-04 | 2025-12-08 | 100,000 | — | $0 | 100,000 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | A Award deriv | 2025-12-04 | 2025-12-08 | 1,000,000 | — | $0 | 1,000,000 | SEC↗ |
| Jones William Benton | See Remarks | A Award deriv | 2025-12-04 | 2025-12-08 | 400,000 | — | $0 | 400,000 | SEC↗ |
| Moore David Scott | Director | A Award deriv | 2025-10-02 | 2025-10-06 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | X Exercise deriv | 2025-06-27 | 2025-07-01 | 1,397,684 | — | $0 | 0 | SEC↗ |
| ORBIMED ADVISORS LLC | Director, 10% Owner | X Exercise deriv | 2025-06-27 | 2025-07-01 | 1,397,684 | — | $0 | 0 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | S Sale | 2025-06-27 | 2025-07-01 | 1,176,332 | $4.16 | $4.89M | 7,165,006 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | X Exercise | 2025-06-27 | 2025-07-01 | 1,397,684 | $3.50 | $4.89M | 8,341,338 | SEC↗ |
| ORBIMED ADVISORS LLC | Director, 10% Owner | X Exercise | 2025-06-27 | 2025-07-01 | 1,397,684 | $3.50 | $4.89M | 8,341,338 | SEC↗ |
| ORBIMED ADVISORS LLC | Director, 10% Owner | S Sale | 2025-06-27 | 2025-07-01 | 1,176,332 | $4.16 | $4.89M | 7,165,006 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | A Award deriv | 2025-06-12 | 2025-06-16 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Morrison Scott W | Director | A Award deriv | 2025-06-12 | 2025-06-16 | 15,000 | — | $0 | 15,000 | SEC↗ |
| CLARK IAN T | Director | A Award deriv | 2025-06-12 | 2025-06-16 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Grais Linda | Director | A Award deriv | 2025-06-12 | 2025-06-16 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Jones William Benton | See Remarks | M Exercise deriv | 2025-06-04 | 2025-06-06 | 19,357 | — | $0 | 0 | SEC↗ |
| Jones William Benton | See Remarks | M Exercise | 2025-06-04 | 2025-06-06 | 19,357 | $3.50 | $67.7K | 173,130 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | M Exercise deriv | 2025-05-07 | 2025-05-09 | 559,073 | — | $0 | 0 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | M Exercise | 2025-05-07 | 2025-05-09 | 559,073 | $3.50 | $1.96M | 1,136,707 | SEC↗ |
| van den Broek Richard | Director | A Award deriv | 2025-04-08 | 2025-04-09 | 30,000 | — | $0 | 30,000 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | A Award deriv | 2024-12-20 | 2024-12-23 | 750,000 | — | $0 | 750,000 | SEC↗ |
| LEA LEIV | Chief Financial Officer | A Award deriv | 2024-12-20 | 2024-12-23 | 300,000 | — | $0 | 300,000 | SEC↗ |
| Jones William Benton | See Remarks | A Award deriv | 2024-12-20 | 2024-12-23 | 300,000 | — | $0 | 300,000 | SEC↗ |
| Arcara Jeffrey | Chief Business Officer | A Award deriv | 2024-12-20 | 2024-12-23 | 50,000 | — | $0 | 50,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | A Award deriv | 2024-06-13 | 2024-06-17 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Gould Terry P | Director, 10% Owner | A Award deriv | 2024-06-13 | 2024-06-17 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Morrison Scott W | Director | A Award deriv | 2024-06-13 | 2024-06-17 | 15,000 | — | $0 | 15,000 | SEC↗ |
| CLARK IAN T | Director | A Award deriv | 2024-06-13 | 2024-06-17 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Grais Linda | Director | A Award deriv | 2024-06-13 | 2024-06-17 | 15,000 | — | $0 | 15,000 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | G Gift | 2024-05-10 | 2024-05-14 | 302,016 | — | $0 | 1,188,103 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy deriv | 2024-05-06 | 2024-05-07 | 559,073 | — | $0 | 559,073 | SEC↗ |
| Jones William Benton | See Remarks | P Buy deriv | 2024-05-06 | 2024-05-07 | 19,357 | — | $0 | 19,357 | SEC↗ |
| OrbiMed Capital GP V LLC | Director, 10% Owner | P Buy deriv | 2024-05-06 | 2024-05-08 | 1,444,085 | $1.73 | $2.50M | 1,444,085 | SEC↗ |
| OrbiMed Capital GP V LLC | Director, 10% Owner | P Buy deriv | 2024-05-06 | 2024-05-08 | 1,397,684 | — | $0 | 1,397,684 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | P Buy deriv | 2024-05-06 | 2024-05-08 | 1,444,085 | $1.73 | $2.50M | 1,444,085 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | P Buy deriv | 2024-05-06 | 2024-05-08 | 1,397,684 | — | $0 | 1,397,684 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2024-05-06 | 2024-05-07 | 577,634 | $1.73 | $999.3K | 577,634 | SEC↗ |
| Jones William Benton | See Remarks | P Buy | 2024-05-06 | 2024-05-07 | 20,000 | $1.73 | $34.6K | 153,773 | SEC↗ |
| Arcara Jeffrey | Chief Business Officer | A Award deriv | 2024-02-28 | 2024-03-01 | 400,000 | — | $0 | 400,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | A Award deriv | 2023-12-06 | 2023-12-08 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Gould Terry P | Director, 10% Owner | A Award deriv | 2023-12-06 | 2023-12-08 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Morrison Scott W | Director | A Award deriv | 2023-12-06 | 2023-12-08 | 15,000 | — | $0 | 15,000 | SEC↗ |
| CLARK IAN T | Director | A Award deriv | 2023-12-06 | 2023-12-08 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Grais Linda | Director | A Award deriv | 2023-12-06 | 2023-12-08 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Mitchell Edith P. | Director | A Award deriv | 2023-12-06 | 2023-12-08 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Jones William Benton | See Remarks | A Award deriv | 2023-12-06 | 2023-12-08 | 200,000 | — | $0 | 200,000 | SEC↗ |
| LEA LEIV | Chief Financial Officer | A Award deriv | 2023-12-06 | 2023-12-08 | 200,000 | — | $0 | 200,000 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | A Award deriv | 2023-12-06 | 2023-12-08 | 500,000 | — | $0 | 500,000 | SEC↗ |
| Mitchell Edith P. | Director | A Award deriv | 2023-06-15 | 2023-06-20 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Grais Linda | Director | A Award deriv | 2023-06-15 | 2023-06-20 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Morrison Scott W | Director | A Award deriv | 2023-06-15 | 2023-06-20 | 15,000 | — | $0 | 15,000 | SEC↗ |
| CLARK IAN T | Director | A Award deriv | 2023-06-15 | 2023-06-20 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Gould Terry P | Director, 10% Owner | A Award deriv | 2023-06-15 | 2023-06-20 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | A Award deriv | 2023-06-15 | 2023-06-20 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Grais Linda | Director | P Buy | 2023-05-15 | 2023-05-16 | 10,000 | $2.45 | $24.5K | 10,000 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | A Award deriv | 2023-03-31 | 2023-04-03 | 800,000 | — | $0 | 800,000 | SEC↗ |
| Jones William Benton | See Remarks | P Buy | 2022-12-20 | 2022-12-20 | 20,000 | $0.79 | $15.8K | 133,773 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2022-12-14 | 2022-12-15 | 10,000 | $0.78 | $7.8K | 1,490,119 | SEC↗ |
| LEA LEIV | Chief Financial Officer | P Buy | 2022-12-14 | 2022-12-15 | 4,000 | $0.84 | $3.4K | 133,238 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2022-12-13 | 2022-12-15 | 50,000 | $0.74 | $37.0K | 1,480,119 | SEC↗ |
| LEA LEIV | Chief Financial Officer | P Buy | 2022-12-13 | 2022-12-15 | 30,000 | $0.74 | $22.2K | 129,238 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2022-09-28 | 2022-09-28 | 25,000 | $0.76 | $19.0K | 1,394,405 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2022-09-20 | 2022-09-20 | 12,300 | $0.81 | $10.0K | 1,361,705 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2022-09-20 | 2022-09-20 | 5,000 | $0.82 | $4.1K | 1,369,405 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2022-09-20 | 2022-09-20 | 2,700 | $0.82 | $2.2K | 1,364,405 | SEC↗ |
| ADAMS STREET PARTNERS LLC | 10% Owner | A Award deriv | 2022-08-11 | 2022-08-15 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | A Award deriv | 2022-08-11 | 2022-08-15 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Gould Terry P | Director, 10% Owner | A Award deriv | 2022-08-11 | 2022-08-15 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Morrison Scott W | Director | A Award deriv | 2022-08-11 | 2022-08-15 | 15,000 | — | $0 | 15,000 | SEC↗ |
| CLARK IAN T | Director | A Award deriv | 2022-08-11 | 2022-08-15 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Grais Linda | Director | A Award deriv | 2022-08-11 | 2022-08-15 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Mitchell Edith P. | Director | A Award deriv | 2022-08-11 | 2022-08-15 | 15,000 | — | $0 | 15,000 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | A Award deriv | 2022-08-11 | 2022-08-15 | 320,000 | — | $0 | 320,000 | SEC↗ |
| LEA LEIV | Chief Financial Officer | A Award deriv | 2022-08-11 | 2022-08-15 | 160,000 | — | $0 | 160,000 | SEC↗ |
| Jones William Benton | See Remarks | A Award deriv | 2022-08-11 | 2022-08-15 | 160,000 | — | $0 | 160,000 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2022-06-27 | 2022-06-28 | 5,000 | $1.00 | $5.0K | 1,349,405 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2022-06-24 | 2022-06-28 | 5,000 | $1.03 | $5.2K | 1,344,405 | SEC↗ |
| Mitchell Edith P. | Director | A Award deriv | 2022-06-15 | 2022-06-17 | 15,000 | — | $0 | 15,000 | SEC↗ |
| CLARK IAN T | Director | A Award deriv | 2022-06-15 | 2022-06-17 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | A Award deriv | 2022-06-15 | 2022-06-17 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Gould Terry P | Director, 10% Owner | A Award deriv | 2022-06-15 | 2022-06-17 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Grais Linda | Director | A Award deriv | 2022-06-15 | 2022-06-17 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Morrison Scott W | Director | A Award deriv | 2022-06-15 | 2022-06-17 | 15,000 | — | $0 | 15,000 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2022-06-06 | 2022-06-06 | 890 | $1.01 | $899 | 1,339,405 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2022-06-02 | 2022-06-06 | 170 | $0.97 | $165 | 1,338,515 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2022-06-02 | 2022-06-06 | 4,830 | $0.98 | $4.7K | 1,338,345 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2022-03-31 | 2022-04-01 | 15,000 | $1.64 | $24.6K | 1,333,515 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2022-03-17 | 2022-03-17 | 5,000 | $1.59 | $8.0K | 1,318,515 | SEC↗ |
| LEA LEIV | Chief Financial Officer | P Buy | 2022-03-17 | 2022-03-17 | 13,878 | $1.65 | $22.9K | 99,238 | SEC↗ |
| LEA LEIV | Chief Financial Officer | P Buy | 2022-03-16 | 2022-03-17 | 35,160 | $1.54 | $54.1K | 85,360 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2022-03-15 | 2022-03-17 | 25,000 | $1.47 | $36.8K | 1,313,515 | SEC↗ |
| EcoR1 Capital, LLC | 10% Owner | S Sale | 2021-10-01 | 2021-10-01 | 2,000,000 | $4.96 | $9.92M | 81,077 | SEC↗ |
| EcoR1 Capital, LLC | 10% Owner | S Sale | 2021-09-30 | 2021-10-01 | 3,000,000 | $5.04 | $15.12M | 2,081,077 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | S Sale | 2021-09-20 | 2021-09-22 | 1,109,644 | $6.09 | $6.76M | 6,943,654 | SEC↗ |
| OrbiMed Capital GP V LLC | Director, 10% Owner | S Sale | 2021-09-20 | 2021-09-22 | 1,109,644 | $6.09 | $6.76M | 6,943,654 | SEC↗ |
| ADAMS STREET PARTNERS LLC | 10% Owner | A Award deriv | 2021-09-09 | 2021-09-13 | 15,000 | — | $0 | 15,000 | SEC↗ |
| CLARK IAN T | Director | A Award deriv | 2021-09-09 | 2021-09-13 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Morrison Scott W | Director | A Award deriv | 2021-09-09 | 2021-09-13 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | A Award deriv | 2021-09-09 | 2021-09-13 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Gould Terry P | Director, 10% Owner | A Award deriv | 2021-09-09 | 2021-09-13 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Mitchell Edith P. | Director | A Award deriv | 2021-09-09 | 2021-09-13 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Grais Linda | Director | A Award deriv | 2021-09-09 | 2021-09-13 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Jones William Benton | See Remarks | A Award deriv | 2021-09-09 | 2021-09-13 | 160,000 | — | $0 | 160,000 | SEC↗ |
| LEA LEIV | Chief Financial Officer | A Award deriv | 2021-09-09 | 2021-09-13 | 160,000 | — | $0 | 160,000 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | A Award deriv | 2021-09-09 | 2021-09-13 | 320,000 | — | $0 | 320,000 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2021-08-20 | 2021-08-23 | 10,000 | $1.93 | $19.3K | 1,288,515 | SEC↗ |
| ADAMS STREET PARTNERS LLC | 10% Owner | A Award deriv | 2021-06-15 | 2021-06-16 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | A Award deriv | 2021-06-15 | 2021-06-16 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Gould Terry P | Director, 10% Owner | A Award deriv | 2021-06-15 | 2021-06-16 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Morrison Scott W | Director | A Award deriv | 2021-06-15 | 2021-06-16 | 15,000 | — | $0 | 15,000 | SEC↗ |
| CLARK IAN T | Director | A Award deriv | 2021-06-15 | 2021-06-16 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Grais Linda | Director | A Award deriv | 2021-06-15 | 2021-06-16 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Mitchell Edith P. | Director | A Award deriv | 2021-06-15 | 2021-06-16 | 15,000 | — | $0 | 15,000 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2021-05-04 | 2021-05-05 | 35,714 | $2.80 | $100.0K | 35,714 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2021-02-17 | 2021-02-17 | 100,000 | $3.50 | $350.0K | 1,278,515 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | P Buy | 2021-02-17 | 2021-02-19 | 1,285,714 | $3.50 | $4.50M | 8,053,298 | SEC↗ |
| ORBIMED ADVISORS LLC | Director, 10% Owner | P Buy | 2021-02-17 | 2021-02-19 | 1,285,714 | $3.50 | $4.50M | 8,053,298 | SEC↗ |
| Mobasher Mehrdad | SVP, Chief Medical Officer | A Award deriv | 2020-12-16 | 2020-12-17 | 85,000 | — | $0 | 85,000 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | A Award deriv | 2020-12-16 | 2020-12-17 | 320,000 | — | $0 | 320,000 | SEC↗ |
| LEA LEIV | Chief Financial Officer | A Award deriv | 2020-12-16 | 2020-12-17 | 160,000 | — | $0 | 160,000 | SEC↗ |
| Jones William Benton | See Remarks | A Award deriv | 2020-12-16 | 2020-12-17 | 160,000 | — | $0 | 160,000 | SEC↗ |
| Mitchell Edith P. | Director | A Award deriv | 2020-09-10 | 2020-09-15 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Novo Holdings A/S | 10% Owner | S Sale | 2020-07-08 | 2020-07-09 | 741,440 | $5.37 | $3.98M | 1,389,498 | SEC↗ |
| Novo Holdings A/S | 10% Owner | S Sale | 2020-07-07 | 2020-07-09 | 796,622 | $5.25 | $4.18M | 2,130,938 | SEC↗ |
| CLARK IAN T | Director | A Award deriv | 2020-06-09 | 2020-06-12 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Grais Linda S | Director | A Award deriv | 2020-06-09 | 2020-06-12 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Gould Terry P | Director, 10% Owner | A Award deriv | 2020-06-09 | 2020-06-12 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Krognes Steve E. | Director | A Award deriv | 2020-06-09 | 2020-06-12 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Morrison Scott W | Director | A Award deriv | 2020-06-09 | 2020-06-12 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | A Award deriv | 2020-06-09 | 2020-06-12 | 15,000 | — | $0 | 15,000 | SEC↗ |
| ADAMS STREET PARTNERS LLC | 10% Owner | A Award deriv | 2020-06-09 | 2020-06-15 | 15,000 | — | $0 | 15,000 | SEC↗ |
| ADAMS STREET PARTNERS LLC | 10% Owner | A Award deriv | 2020-03-19 | 2020-03-23 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Gould Terry P | Director, 10% Owner | A Award deriv | 2020-03-19 | 2020-03-23 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | A Award deriv | 2020-03-19 | 2020-03-23 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Morrison Scott W | Director | A Award deriv | 2020-03-19 | 2020-03-23 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Krognes Steve E. | Director | A Award deriv | 2020-03-19 | 2020-03-23 | 15,000 | — | $0 | 15,000 | SEC↗ |
| CLARK IAN T | Director | A Award deriv | 2020-03-19 | 2020-03-23 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Grais Linda S | Director | A Award deriv | 2020-03-19 | 2020-03-23 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Buggy Joseph J | EVP, Discovery Research | A Award deriv | 2019-12-12 | 2019-12-16 | 40,000 | — | $0 | 40,000 | SEC↗ |
| Hunt Daniel W. | SVP, Chief Business Officer | A Award deriv | 2019-12-12 | 2019-12-16 | 75,000 | — | $0 | 75,000 | SEC↗ |
| Jones William Benton | See Remarks | A Award deriv | 2019-12-12 | 2019-12-16 | 160,000 | — | $0 | 160,000 | SEC↗ |
| LEA LEIV | Chief Financial Officer | A Award deriv | 2019-12-12 | 2019-12-16 | 160,000 | — | $0 | 160,000 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | A Award deriv | 2019-12-12 | 2019-12-16 | 320,000 | — | $0 | 320,000 | SEC↗ |
| Mobasher Mehrdad | VP, Chief Medical Officer | A Award deriv | 2019-12-12 | 2019-12-16 | 50,000 | — | $0 | 50,000 | SEC↗ |
| Verner Erik J. | VP, Chemistry Research | A Award deriv | 2019-12-12 | 2019-12-16 | 50,000 | — | $0 | 50,000 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2019-11-13 | 2019-11-14 | 14,736 | $3.00 | $44.2K | 1,178,515 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2019-11-12 | 2019-11-14 | 272 | $2.90 | $789 | 1,163,779 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2019-08-07 | 2019-08-08 | 2,500 | $3.54 | $8.8K | 1,163,507 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2019-08-06 | 2019-08-08 | 5,000 | $3.58 | $17.9K | 1,161,007 | SEC↗ |
| OrbiMed Capital GP V LLC | Director, 10% Owner | P Buy | 2019-08-06 | 2019-08-08 | 142,656 | $3.51 | $500.7K | 6,767,584 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | P Buy | 2019-08-06 | 2019-08-08 | 142,656 | $3.51 | $500.7K | 6,767,584 | SEC↗ |
| Novo Holdings A/S | 10% Owner | S Sale | 2019-07-25 | 2019-07-25 | 1,400,000 | $4.00 | $5.60M | 2,927,560 | SEC↗ |
| Novo Holdings A/S | 10% Owner | S Sale | 2019-07-24 | 2019-07-25 | 53,240 | $5.01 | $266.7K | 4,327,560 | SEC↗ |
| Novo Holdings A/S | 10% Owner | S Sale | 2019-07-23 | 2019-07-25 | 39,716 | $5.32 | $211.3K | 4,380,800 | SEC↗ |
| ORBIMED ADVISORS LLC | Director, 10% Owner | P Buy | 2019-07-01 | 2019-07-01 | 59,243 | $3.91 | $231.6K | 6,624,928 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | P Buy | 2019-07-01 | 2019-07-01 | 59,243 | $3.91 | $231.6K | 6,624,928 | SEC↗ |
| ORBIMED ADVISORS LLC | Director, 10% Owner | P Buy | 2019-06-28 | 2019-07-01 | 565,178 | $3.72 | $2.10M | 6,565,685 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | P Buy | 2019-06-28 | 2019-07-01 | 565,178 | $3.72 | $2.10M | 6,565,685 | SEC↗ |
| ORBIMED ADVISORS LLC | Director, 10% Owner | P Buy | 2019-06-27 | 2019-07-01 | 32,923 | $3.34 | $110.0K | 6,000,507 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | P Buy | 2019-06-27 | 2019-07-01 | 32,923 | $3.34 | $110.0K | 6,000,507 | SEC↗ |
| CLARK IAN T | Director | A Award deriv | 2019-06-20 | 2019-06-24 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | A Award deriv | 2019-06-20 | 2019-06-24 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Grais Linda S | Director | A Award deriv | 2019-06-20 | 2019-06-24 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Gould Terry P | Director, 10% Owner | A Award deriv | 2019-06-20 | 2019-06-24 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Morrison Scott W | Director | A Award deriv | 2019-06-20 | 2019-06-24 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Krognes Steve E. | Director | A Award deriv | 2019-06-20 | 2019-06-24 | 15,000 | — | $0 | 15,000 | SEC↗ |
| ADAMS STREET PARTNERS LLC | 10% Owner | A Award deriv | 2019-06-20 | 2019-06-24 | 15,000 | — | $0 | 15,000 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2019-06-14 | 2019-06-17 | 11,657 | $3.40 | $39.6K | 1,156,007 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2019-06-13 | 2019-06-17 | 343 | $3.52 | $1.2K | 1,144,350 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2019-06-11 | 2019-06-11 | 6,000 | $3.67 | $22.0K | 1,144,007 | SEC↗ |
| LEA LEIV | Chief Financial Officer | P Buy | 2019-06-07 | 2019-06-10 | 10,000 | $3.38 | $33.8K | 50,200 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2019-06-07 | 2019-06-11 | 9,212 | $3.37 | $31.0K | 1,138,007 | SEC↗ |
| LEA LEIV | Chief Financial Officer | P Buy | 2019-06-06 | 2019-06-10 | 15,500 | $3.56 | $55.2K | 40,200 | SEC↗ |
| Mobasher Mehrdad | Chief Medical Officer | A Award deriv | 2019-01-28 | 2019-01-30 | 210,000 | — | $0 | 210,000 | SEC↗ |
| Grais Linda S | Director | A Award deriv | 2019-01-28 | 2019-01-30 | 30,000 | — | $0 | 30,000 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2018-12-27 | 2018-12-31 | 20,000 | $3.29 | $65.8K | 1,128,795 | SEC↗ |
| LEA LEIV | Chief Financial Officer | P Buy | 2018-12-21 | 2018-12-27 | 24,700 | $4.15 | $102.5K | 24,700 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2018-12-20 | 2018-12-26 | 5,000 | $4.40 | $22.0K | 1,103,795 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2018-12-20 | 2018-12-26 | 5,000 | $4.39 | $21.9K | 1,108,795 | SEC↗ |
| Verner Erik J. | V.P., Chemistry Research | A Award deriv | 2018-12-12 | 2018-12-14 | 50,000 | — | $0 | 50,000 | SEC↗ |
| Hunt Daniel W. | SVP, Chief Business Officer | A Award deriv | 2018-12-12 | 2018-12-14 | 50,000 | — | $0 | 50,000 | SEC↗ |
| LEA LEIV | Chief Financial Officer | A Award deriv | 2018-12-12 | 2018-12-14 | 100,000 | — | $0 | 100,000 | SEC↗ |
| Buggy Joseph J | EVP Discovery Research | A Award deriv | 2018-12-12 | 2018-12-14 | 100,000 | — | $0 | 100,000 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | A Award deriv | 2018-12-12 | 2018-12-14 | 250,000 | — | $0 | 250,000 | SEC↗ |
| Jones William Benton | See Remarks | A Award deriv | 2018-12-12 | 2018-12-14 | 100,000 | — | $0 | 100,000 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | G Gift | 2018-12-11 | 2018-12-14 | 10,000 | — | $0 | 1,098,795 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | G Gift | 2018-12-11 | 2018-12-14 | 10,000 | — | $0 | 1,108,795 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2018-12-06 | 2018-12-10 | 5,000 | $5.99 | $29.9K | 1,118,795 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2018-12-04 | 2018-12-06 | 1,502 | $5.95 | $8.9K | 1,113,795 | SEC↗ |
| Krognes Steve E. | Director | A Award deriv | 2018-06-21 | 2018-06-25 | 15,000 | — | $0 | 15,000 | SEC↗ |
| CLARK IAN T | Director | A Award deriv | 2018-06-21 | 2018-06-25 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Gould Terry P | Director, 10% Owner | A Award deriv | 2018-06-21 | 2018-06-25 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Morrison Scott W | Director | A Award deriv | 2018-06-21 | 2018-06-25 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | A Award deriv | 2018-06-21 | 2018-06-25 | 15,000 | — | $0 | 15,000 | SEC↗ |
| ADAMS STREET PARTNERS LLC | 10% Owner | A Award deriv | 2018-06-21 | 2018-06-25 | 15,000 | — | $0 | 15,000 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2018-03-12 | 2018-03-12 | 100,000 | $8.50 | $850.0K | 1,112,293 | SEC↗ |
| ADAMS STREET PARTNERS LLC | 10% Owner | P Buy | 2018-03-12 | 2018-03-13 | 67,769 | $8.50 | $576.0K | 67,769 | SEC↗ |
| ADAMS STREET PARTNERS LLC | 10% Owner | P Buy | 2018-03-12 | 2018-03-13 | 87,668 | $8.50 | $745.2K | 87,668 | SEC↗ |
| ADAMS STREET PARTNERS LLC | 10% Owner | P Buy | 2018-03-12 | 2018-03-13 | 126,806 | $8.50 | $1.08M | 126,806 | SEC↗ |
| ADAMS STREET PARTNERS LLC | 10% Owner | P Buy | 2018-03-12 | 2018-03-13 | 236,128 | $8.50 | $2.01M | 236,128 | SEC↗ |
| ADAMS STREET PARTNERS LLC | 10% Owner | P Buy | 2018-03-12 | 2018-03-13 | 69,864 | $8.50 | $593.8K | 69,864 | SEC↗ |
| Gould Terry P | Director, 10% Owner | P Buy | 2018-03-12 | 2018-03-13 | 69,864 | $8.50 | $593.8K | 69,864 | SEC↗ |
| Gould Terry P | Director, 10% Owner | P Buy | 2018-03-12 | 2018-03-13 | 236,128 | $8.50 | $2.01M | 236,128 | SEC↗ |
| Gould Terry P | Director, 10% Owner | P Buy | 2018-03-12 | 2018-03-13 | 67,769 | $8.50 | $576.0K | 67,769 | SEC↗ |
| Gould Terry P | Director, 10% Owner | P Buy | 2018-03-12 | 2018-03-13 | 87,668 | $8.50 | $745.2K | 87,668 | SEC↗ |
| Gould Terry P | Director, 10% Owner | P Buy | 2018-03-12 | 2018-03-13 | 126,806 | $8.50 | $1.08M | 126,806 | SEC↗ |
| Novo Holdings A/S | 10% Owner | P Buy | 2018-03-12 | 2018-03-13 | 1,176,470 | $8.50 | $10.00M | 4,420,516 | SEC↗ |
| ORBIMED ADVISORS LLC | Director, 10% Owner | P Buy | 2018-03-12 | 2018-03-14 | 588,235 | $8.50 | $5.00M | 5,967,584 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | P Buy | 2018-03-12 | 2018-03-14 | 588,235 | $8.50 | $5.00M | 5,967,584 | SEC↗ |
| Buggy Joseph J | EVP Discovery Research | A Award deriv | 2018-01-19 | 2018-01-23 | 100,000 | — | $0 | 100,000 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | A Award deriv | 2017-12-13 | 2017-12-15 | 125,000 | — | $0 | 125,000 | SEC↗ |
| LEA LEIV | Chief Financial Officer | A Award deriv | 2017-12-13 | 2017-12-15 | 40,000 | — | $0 | 40,000 | SEC↗ |
| Hunt Daniel W. | SVP, Chief Business Officer | A Award deriv | 2017-12-13 | 2017-12-15 | 200,000 | — | $0 | 200,000 | SEC↗ |
| Jones William Benton | See Remarks | A Award deriv | 2017-12-13 | 2017-12-15 | 40,000 | — | $0 | 40,000 | SEC↗ |
| Verner Erik J. | V.P., Chemistry Research | A Award deriv | 2017-12-13 | 2017-12-15 | 25,000 | — | $0 | 25,000 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2017-11-20 | 2017-11-22 | 10,000 | $10.79 | $107.9K | 1,012,293 | SEC↗ |
| Novo Holdings A/S | 10% Owner | P Buy | 2017-06-23 | 2017-06-27 | 20,000 | $10.95 | $219.0K | 3,244,046 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2017-06-13 | 2017-06-13 | 2,500 | $9.75 | $24.4K | 999,793 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2017-06-13 | 2017-06-13 | 2,500 | $10.14 | $25.4K | 1,002,293 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2017-06-12 | 2017-06-13 | 11,216 | $9.82 | $110.1K | 997,293 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2017-06-09 | 2017-06-13 | 3,784 | $9.89 | $37.4K | 986,077 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2017-06-09 | 2017-06-13 | 5,000 | $9.95 | $49.8K | 982,293 | SEC↗ |
| ADAMS STREET PARTNERS LLC | 10% Owner | A Award deriv | 2017-06-08 | 2017-06-09 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Morrison Scott W | Director | A Award deriv | 2017-06-08 | 2017-06-09 | 15,000 | — | $0 | 15,000 | SEC↗ |
| CLARK IAN T | Director | A Award deriv | 2017-06-08 | 2017-06-09 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Krognes Steve E. | Director | A Award deriv | 2017-06-08 | 2017-06-09 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | A Award deriv | 2017-06-08 | 2017-06-09 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Gould Terry P | Director, 10% Owner | A Award deriv | 2017-06-08 | 2017-06-09 | 15,000 | — | $0 | 15,000 | SEC↗ |
| CLARK IAN T | Director | A Award deriv | 2017-01-03 | 2017-01-04 | 30,000 | — | $0 | 30,000 | SEC↗ |
| LEA LEIV | Chief Financial Officer | A Award deriv | 2016-12-07 | 2016-12-08 | 25,000 | — | $0 | 25,000 | SEC↗ |
| Jones William Benton | VP Pharmaceutical Developmen | A Award deriv | 2016-12-07 | 2016-12-08 | 25,000 | — | $0 | 25,000 | SEC↗ |
| Verner Erik J. | V.P., Chemistry Research | A Award deriv | 2016-12-07 | 2016-12-08 | 25,000 | — | $0 | 25,000 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | A Award deriv | 2016-12-07 | 2016-12-08 | 160,000 | — | $0 | 160,000 | SEC↗ |
| ORBIMED ADVISORS LLC | Director, 10% Owner | P Buy | 2016-06-24 | 2016-06-27 | 900 | $12.99 | $11.7K | 5,379,349 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | P Buy | 2016-06-24 | 2016-06-27 | 900 | $12.99 | $11.7K | 5,379,349 | SEC↗ |
| ORBIMED ADVISORS LLC | Director, 10% Owner | P Buy | 2016-06-23 | 2016-06-27 | 100 | $12.92 | $1.3K | 5,378,449 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | P Buy | 2016-06-23 | 2016-06-27 | 100 | $12.92 | $1.3K | 5,378,449 | SEC↗ |
| OrbiMed Capital GP V LLC | Director, 10% Owner | P Buy | 2016-06-21 | 2016-06-21 | 26,083 | $12.87 | $335.7K | 5,378,349 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | P Buy | 2016-06-21 | 2016-06-21 | 26,083 | $12.87 | $335.7K | 5,378,349 | SEC↗ |
| OrbiMed Capital GP V LLC | Director, 10% Owner | P Buy | 2016-06-17 | 2016-06-21 | 12,300 | $12.48 | $153.5K | 5,352,266 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | P Buy | 2016-06-17 | 2016-06-21 | 12,300 | $12.48 | $153.5K | 5,352,266 | SEC↗ |
| OrbiMed Capital GP V LLC | Director, 10% Owner | P Buy | 2016-06-16 | 2016-06-16 | 5,000 | $12.04 | $60.2K | 5,339,966 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | P Buy | 2016-06-16 | 2016-06-16 | 5,000 | $12.04 | $60.2K | 5,339,966 | SEC↗ |
| OrbiMed Capital GP V LLC | Director, 10% Owner | P Buy | 2016-06-15 | 2016-06-16 | 5,000 | $11.94 | $59.7K | 5,334,966 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | P Buy | 2016-06-15 | 2016-06-16 | 5,000 | $11.94 | $59.7K | 5,334,966 | SEC↗ |
| OrbiMed Capital GP V LLC | Director, 10% Owner | P Buy | 2016-06-14 | 2016-06-16 | 10,000 | $12.71 | $127.1K | 5,329,966 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | P Buy | 2016-06-14 | 2016-06-16 | 10,000 | $12.71 | $127.1K | 5,329,966 | SEC↗ |
| ORBIMED ADVISORS LLC | Director, 10% Owner | P Buy | 2016-06-10 | 2016-06-13 | 20,000 | $12.98 | $259.6K | 5,319,966 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | P Buy | 2016-06-10 | 2016-06-13 | 20,000 | $12.98 | $259.6K | 5,319,966 | SEC↗ |
| ORBIMED ADVISORS LLC | Director, 10% Owner | P Buy | 2016-06-09 | 2016-06-13 | 30,000 | $12.95 | $388.5K | 5,299,966 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | P Buy | 2016-06-09 | 2016-06-13 | 30,000 | $12.95 | $388.5K | 5,299,966 | SEC↗ |
| Coloma Jason V | SVP, Chief Business Officer | A Award deriv | 2016-06-08 | 2016-06-10 | 200,000 | — | $0 | 200,000 | SEC↗ |
| ORBIMED ADVISORS LLC | Director, 10% Owner | P Buy | 2016-05-20 | 2016-05-24 | 4,716 | $13.09 | $61.7K | 5,269,966 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | P Buy | 2016-05-20 | 2016-05-24 | 4,716 | $13.09 | $61.7K | 5,269,966 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | P Buy | 2016-05-19 | 2016-05-20 | 2,539 | $12.11 | $30.7K | 5,265,189 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | P Buy | 2016-05-19 | 2016-05-20 | 61 | $12.75 | $778 | 5,265,250 | SEC↗ |
| ORBIMED ADVISORS LLC | Director | P Buy | 2016-05-19 | 2016-05-20 | 61 | $12.75 | $778 | 5,265,250 | SEC↗ |
| ORBIMED ADVISORS LLC | Director | P Buy | 2016-05-19 | 2016-05-20 | 2,539 | $12.11 | $30.7K | 5,265,189 | SEC↗ |
| Thompson Peter A. | Director, 10% Owner | P Buy | 2016-05-18 | 2016-05-20 | 4,200 | $11.55 | $48.5K | 5,262,650 | SEC↗ |
| ORBIMED ADVISORS LLC | Director | P Buy | 2016-05-18 | 2016-05-20 | 4,200 | $11.55 | $48.5K | 5,262,650 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2016-05-13 | 2016-05-16 | 300 | $9.94 | $3.0K | 1,077,293 | SEC↗ |
| Novo A/S | 10% Owner | P Buy | 2016-05-12 | 2016-05-16 | 70,000 | $10.00 | $700.0K | 3,224,046 | SEC↗ |
| MILLER RICHARD A MD | President and CEO | P Buy | 2016-05-12 | 2016-05-16 | 30,000 | $10.00 | $300.0K | 1,076,993 | SEC↗ |
| Gould Terry P | Director, 10% Owner | C Conversion deriv | 2016-03-29 | 2016-03-29 | 567,121 | — | $0 | 0 | SEC↗ |
| Gould Terry P | Director, 10% Owner | C Conversion deriv | 2016-03-29 | 2016-03-29 | 92,278 | — | $0 | 0 | SEC↗ |