Open-mkt buys · 90d
—
0 trades · 0 insiders
Open-mkt sales · 90d
$870.6K
10 trades · 3 insiders
Net · 90d
$-870.6K
Insiders on file
29
Daily buy vs sell · 90 days
■ Open-market buys (P) ■ Open-market sales (S) · daily dollar value by transaction date
Insiders
| Insider | Role | Trades | Bought | Sold | Last trade |
|---|---|---|---|---|---|
| Chin Peter Scott | Chief Medical Officer | 2 | $0 | $73.7K | 2026-09-04 |
| Thornberry Nancy | Director | 17 | $0 | $523.9K | 2026-09-02 |
| Schuth Alexander O. | COO and Secretary | 192 | $0 | $18.68M | 2026-09-01 |
| Watts Ryan J. | President and CEO, Director | 182 | $0 | $41.18M | 2026-08-12 |
| Van Hauwermeiren Timothy | Director | 4 | $0 | $0 | 2026-06-03 |
| Cook Jennifer E. | Director | 19 | $0 | $31.7K | 2026-06-03 |
| Krognes Steve E. | Director | 70 | $0 | $15.19M | 2026-06-03 |
| Schenkein David P | Director | 36 | $0 | $7.84M | 2026-06-03 |
| Klein Peter S | Director | 18 | $0 | $0 | 2026-06-03 |
| Baker Brothers Life Sciences LP | Director | 4 | $0 | $0 | 2026-06-03 |
| FLATLEY JAY T | Director | 21 | $0 | $0 | 2026-06-03 |
| BAKER JULIAN | Director | 2 | $39.98M | $0 | 2025-12-11 |
| Ho Carole | Chief Medical Officer | 210 | $0 | $13.21M | 2025-08-13 |
| Tessier-Lavigne Marc | Director | 72 | $0 | $36.87M | 2025-06-03 |
| BAKER BROS. ADVISORS LP | Director | 4 | $0 | $0 | 2025-06-03 |
| SATO VICKI L | Director | 65 | $0 | $1.78M | 2025-01-02 |
| Harris Erik | Director | 6 | $0 | $0 | 2024-05-31 |
| Cole Douglas G. | Director | 13 | $0 | $0 | 2023-06-01 |
| NELSEN ROBERT | Director, 10% Owner | 17 | $0 | $0 | 2021-06-02 |
| BRATTON DOUGLAS K | 10% Owner | 7 | $0 | $150.40M | 2021-02-12 |
| Bratton Capital Inc. | 10% Owner | 4 | $0 | $5.18M | 2020-12-21 |
| Crestline Management, LP | 10% Owner | 1 | $0 | $45.68M | 2020-08-12 |
| Bratton Capital Management, L.P. | 10% Owner | 6 | $0 | $5.99M | 2020-06-30 |
| Crestline Investors, Inc. | 10% Owner | 15 | $4.95M | $128.38M | 2020-06-05 |
| Neuro Line Partners LP | 10% Owner | 1 | $0 | $0 | 2019-03-25 |
| FIL Ltd | Other | 42 | $0 | $0 | 2017-12-12 |
| FMR LLC | Other | 18 | $0 | $0 | 2017-12-12 |
| Flagship Ventures Fund V General Partner LLC | 10% Owner | 4 | $0 | $0 | 2017-12-12 |
| ARCH Venture Fund VIII, L.P. | 10% Owner | 4 | $0 | $0 | 2017-12-12 |
Trade history
| Insider | Role | Code | Trade | Filed | Shares | Price | Value | Owned after | |
|---|---|---|---|---|---|---|---|---|---|
| Chin Peter Scott | Chief Medical Officer | S Sale | 2026-09-04 | 2026-09-09 | 1,654 | $22.29 | $36.9K | 204,538 | SEC↗ |
| Chin Peter Scott | Chief Medical Officer | S Sale | 2026-09-04 | 2026-09-09 | 1,654 | $22.29 | $36.9K | 204,538 | SEC↗ |
| Thornberry Nancy | Director | S Sale | 2026-09-02 | 2026-09-04 | 615 | $23.74 | $14.6K | 19,686 | SEC↗ |
| Thornberry Nancy | Director | S Sale | 2026-09-02 | 2026-09-04 | 10,824 | $22.85 | $247.3K | 20,301 | SEC↗ |
| Thornberry Nancy | Director | S Sale | 2026-09-02 | 2026-09-04 | 615 | $23.74 | $14.6K | 19,686 | SEC↗ |
| Thornberry Nancy | Director | S Sale | 2026-09-02 | 2026-09-04 | 10,824 | $22.85 | $247.3K | 20,301 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2026-09-01 | 2026-09-03 | 2,768 | $23.44 | $64.9K | 278,995 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2026-09-01 | 2026-09-03 | 2,768 | $23.44 | $64.9K | 278,995 | SEC↗ |
| Watts Ryan J. | President and CEO | G Gift | 2026-08-12 | 2026-08-14 | 32,220 | — | $0 | 2,120,384 | SEC↗ |
| Watts Ryan J. | President and CEO, Director | G Gift | 2026-08-12 | 2026-08-14 | 32,220 | — | $0 | 2,120,384 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2026-08-11 | 2026-08-13 | 2,857 | $25.07 | $71.6K | 281,763 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2026-08-11 | 2026-08-13 | 2,857 | $25.07 | $71.6K | 281,763 | SEC↗ |
| Baker Brothers Life Sciences L | Director | A Award deriv | 2026-06-03 | 2026-06-05 | 19,226 | — | $0 | 19,226 | SEC↗ |
| Baker Brothers Life Sciences L | Director | A Award deriv | 2026-06-03 | 2026-06-05 | 19,226 | — | $0 | 19,226 | SEC↗ |
| Cook Jennifer E. | Director | A Award deriv | 2026-06-03 | 2026-06-05 | 19,226 | — | $0 | 19,226 | SEC↗ |
| Van Hauwermeiren Timothy | Director | A Award deriv | 2026-06-03 | 2026-06-05 | 19,226 | — | $0 | 19,226 | SEC↗ |
| Thornberry Nancy | Director | A Award deriv | 2026-06-03 | 2026-06-05 | 19,226 | — | $0 | 19,226 | SEC↗ |
| Schenkein David P | Director | A Award deriv | 2026-06-03 | 2026-06-05 | 19,226 | — | $0 | 19,226 | SEC↗ |
| Krognes Steve E. | Director | A Award deriv | 2026-06-03 | 2026-06-05 | 19,226 | — | $0 | 19,226 | SEC↗ |
| Klein Peter S | Director | A Award deriv | 2026-06-03 | 2026-06-05 | 19,226 | — | $0 | 19,226 | SEC↗ |
| FLATLEY JAY T | Director | A Award deriv | 2026-06-03 | 2026-06-05 | 19,226 | — | $0 | 19,226 | SEC↗ |
| Baker Brothers Life Sciences L | Director | A Award | 2026-06-03 | 2026-06-05 | 6,408 | — | $0 | 3,422,366 | SEC↗ |
| Baker Brothers Life Sciences L | Director | A Award | 2026-06-03 | 2026-06-05 | 6,408 | — | $0 | 343,275 | SEC↗ |
| Cook Jennifer E. | Director | A Award | 2026-06-03 | 2026-06-05 | 6,408 | — | $0 | 32,483 | SEC↗ |
| Van Hauwermeiren Timothy | Director | A Award | 2026-06-03 | 2026-06-05 | 6,408 | — | $0 | 17,040 | SEC↗ |
| Thornberry Nancy | Director | A Award | 2026-06-03 | 2026-06-05 | 6,408 | — | $0 | 31,125 | SEC↗ |
| Schenkein David P | Director | A Award | 2026-06-03 | 2026-06-05 | 6,408 | — | $0 | 21,665 | SEC↗ |
| Krognes Steve E. | Director | A Award | 2026-06-03 | 2026-06-05 | 6,408 | — | $0 | 38,202 | SEC↗ |
| Klein Peter S | Director | A Award | 2026-06-03 | 2026-06-05 | 6,408 | — | $0 | 33,941 | SEC↗ |
| FLATLEY JAY T | Director | A Award | 2026-06-03 | 2026-06-05 | 6,408 | — | $0 | 22,628 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2026-01-06 | 2026-01-08 | 17,218 | $16.50 | $284.1K | 282,828 | SEC↗ |
| Watts Ryan J. | President and CEO | S Sale | 2026-01-06 | 2026-01-08 | 35,198 | $16.50 | $580.8K | 296,833 | SEC↗ |
| Watts Ryan J. | President and CEO | A Award deriv | 2026-01-03 | 2026-01-05 | 236,880 | — | $0 | 236,880 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | A Award deriv | 2026-01-03 | 2026-01-05 | 173,100 | — | $0 | 173,100 | SEC↗ |
| Watts Ryan J. | President and CEO | A Award | 2026-01-03 | 2026-01-05 | 78,960 | — | $0 | 332,031 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | A Award | 2026-01-03 | 2026-01-05 | 57,700 | — | $0 | 300,046 | SEC↗ |
| BAKER JULIAN | Director | P Buy deriv | 2025-12-11 | 2025-12-15 | 190,523 | $17.49 | $3.33M | 2,335,469 | SEC↗ |
| BAKER JULIAN | Director | P Buy deriv | 2025-12-11 | 2025-12-15 | 2,095,191 | $17.49 | $36.64M | 25,996,310 | SEC↗ |
| Van Hauwermeiren Timothy | Director | A Award deriv | 2025-11-04 | 2025-11-06 | 31,897 | — | $0 | 31,897 | SEC↗ |
| Van Hauwermeiren Timothy | Director | A Award | 2025-11-04 | 2025-11-06 | 10,632 | — | $0 | 10,632 | SEC↗ |
| Watts Ryan J. | President and CEO | G Gift | 2025-09-03 | 2025-09-05 | 50,000 | — | $0 | 2,152,604 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2025-08-13 | 2025-08-14 | 806 | $14.64 | $11.8K | 216,585 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2025-08-12 | 2025-08-14 | 2,937 | $13.58 | $39.9K | 217,391 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2025-08-12 | 2025-08-14 | 2,937 | $13.58 | $39.9K | 242,346 | SEC↗ |
| Ho Carole | Chief Medical Officer | M Exercise deriv | 2025-08-05 | 2025-08-07 | 44,655 | — | $0 | 62,500 | SEC↗ |
| Ho Carole | Chief Medical Officer | M Exercise | 2025-08-05 | 2025-08-07 | 44,655 | $0.68 | $30.4K | 220,328 | SEC↗ |
| Watts Ryan J. | President and CEO | M Exercise deriv | 2025-07-09 | 2025-07-11 | 40,000 | — | $0 | 20,369 | SEC↗ |
| Watts Ryan J. | President and CEO | M Exercise deriv | 2025-07-09 | 2025-07-11 | 455,282 | — | $0 | 622,809 | SEC↗ |
| Watts Ryan J. | President and CEO | M Exercise | 2025-07-09 | 2025-07-11 | 455,282 | $0.68 | $309.6K | 708,353 | SEC↗ |
| Watts Ryan J. | President and CEO | S Sale | 2025-07-09 | 2025-07-11 | 495,282 | $15.00 | $7.43M | 253,071 | SEC↗ |
| Watts Ryan J. | President and CEO | M Exercise | 2025-07-09 | 2025-07-11 | 40,000 | $5.28 | $211.2K | 748,353 | SEC↗ |
| Tessier-Lavigne Marc | Director | A Award deriv | 2025-06-03 | 2025-06-05 | 18,111 | — | $0 | 18,111 | SEC↗ |
| Thornberry Nancy | Director | A Award deriv | 2025-06-03 | 2025-06-05 | 18,111 | — | $0 | 18,111 | SEC↗ |
| Schenkein David P | Director | A Award deriv | 2025-06-03 | 2025-06-05 | 18,111 | — | $0 | 18,111 | SEC↗ |
| Krognes Steve E. | Director | A Award deriv | 2025-06-03 | 2025-06-05 | 18,111 | — | $0 | 18,111 | SEC↗ |
| Klein Peter S | Director | A Award deriv | 2025-06-03 | 2025-06-05 | 18,111 | — | $0 | 18,111 | SEC↗ |
| FLATLEY JAY T | Director | A Award deriv | 2025-06-03 | 2025-06-05 | 18,111 | — | $0 | 18,111 | SEC↗ |
| Cook Jennifer E. | Director | A Award deriv | 2025-06-03 | 2025-06-05 | 18,111 | — | $0 | 18,111 | SEC↗ |
| BAKER BROS. ADVISORS LP | Director | A Award deriv | 2025-06-03 | 2025-06-05 | 31,695 | — | $0 | 31,695 | SEC↗ |
| BAKER BROS. ADVISORS LP | Director | A Award deriv | 2025-06-03 | 2025-06-05 | 31,695 | — | $0 | 31,695 | SEC↗ |
| Tessier-Lavigne Marc | Director | A Award | 2025-06-03 | 2025-06-05 | 6,037 | — | $0 | 1,886,576 | SEC↗ |
| Thornberry Nancy | Director | A Award | 2025-06-03 | 2025-06-05 | 6,037 | — | $0 | 24,717 | SEC↗ |
| Schenkein David P | Director | A Award | 2025-06-03 | 2025-06-05 | 6,037 | — | $0 | 15,257 | SEC↗ |
| Krognes Steve E. | Director | A Award | 2025-06-03 | 2025-06-05 | 6,037 | — | $0 | 31,794 | SEC↗ |
| Klein Peter S | Director | A Award | 2025-06-03 | 2025-06-05 | 6,037 | — | $0 | 27,533 | SEC↗ |
| FLATLEY JAY T | Director | A Award | 2025-06-03 | 2025-06-05 | 6,037 | — | $0 | 16,220 | SEC↗ |
| Cook Jennifer E. | Director | A Award | 2025-06-03 | 2025-06-05 | 6,037 | — | $0 | 26,075 | SEC↗ |
| BAKER BROS. ADVISORS LP | Director | A Award | 2025-06-03 | 2025-06-05 | 10,565 | — | $0 | 3,415,958 | SEC↗ |
| BAKER BROS. ADVISORS LP | Director | A Award | 2025-06-03 | 2025-06-05 | 10,565 | — | $0 | 336,867 | SEC↗ |
| Krognes Steve E. | Director | S Sale | 2025-01-07 | 2025-01-08 | 3,339 | $20.81 | $69.5K | 25,757 | SEC↗ |
| Watts Ryan J. | President and CEO | S Sale | 2025-01-07 | 2025-01-08 | 7,650 | $20.81 | $159.2K | 253,071 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2025-01-07 | 2025-01-08 | 2,907 | $20.81 | $60.5K | 244,308 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2025-01-07 | 2025-01-08 | 2,907 | $20.81 | $60.5K | 175,673 | SEC↗ |
| Watts Ryan J. | President and CEO | S Sale | 2025-01-06 | 2025-01-08 | 29,266 | $20.22 | $591.8K | 260,721 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2025-01-06 | 2025-01-08 | 12,255 | $20.22 | $247.8K | 247,215 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2025-01-06 | 2025-01-08 | 12,255 | $20.22 | $247.8K | 178,580 | SEC↗ |
| Ho Carole | Chief Medical Officer | A Award deriv | 2025-01-03 | 2025-01-07 | 162,540 | — | $0 | 162,540 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | A Award deriv | 2025-01-03 | 2025-01-07 | 162,540 | — | $0 | 162,540 | SEC↗ |
| Watts Ryan J. | President and CEO | A Award deriv | 2025-01-03 | 2025-01-07 | 162,540 | — | $0 | 162,540 | SEC↗ |
| Ho Carole | Chief Medical Officer | A Award | 2025-01-03 | 2025-01-07 | 54,180 | — | $0 | 190,835 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | A Award | 2025-01-03 | 2025-01-07 | 54,180 | — | $0 | 259,470 | SEC↗ |
| Watts Ryan J. | President and CEO | A Award | 2025-01-03 | 2025-01-07 | 54,180 | — | $0 | 289,987 | SEC↗ |
| SATO VICKI L | Director | S Sale | 2025-01-02 | 2025-01-03 | 3,080 | $20.91 | $64.4K | 107,976 | SEC↗ |
| Krognes Steve E. | Director | S Sale | 2024-12-31 | 2025-01-03 | 30,000 | $20.25 | $607.5K | 29,096 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | M Exercise deriv | 2024-12-27 | 2024-12-31 | 6,708 | — | $0 | 46,671 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | M Exercise | 2024-12-27 | 2024-12-31 | 6,708 | $5.28 | $35.4K | 205,290 | SEC↗ |
| Ho Carole | Chief Medical Officer | M Exercise deriv | 2024-11-25 | 2024-11-27 | 17,845 | — | $0 | 107,155 | SEC↗ |
| Ho Carole | Chief Medical Officer | M Exercise | 2024-11-25 | 2024-11-27 | 17,845 | $0.68 | $12.1K | 136,655 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | M Exercise deriv | 2024-11-22 | 2024-11-26 | 20,516 | — | $0 | 124,562 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | M Exercise | 2024-11-22 | 2024-11-26 | 20,516 | $0.68 | $14.0K | 198,582 | SEC↗ |
| Schenkein David P | Director | M Exercise deriv | 2024-11-11 | 2024-11-13 | 47,165 | — | $0 | 0 | SEC↗ |
| Schenkein David P | Director | S Sale | 2024-11-11 | 2024-11-13 | 32,312 | $32.87 | $1.06M | 9,220 | SEC↗ |
| Schenkein David P | Director | S Sale | 2024-11-11 | 2024-11-13 | 27,129 | $32.09 | $870.6K | 41,532 | SEC↗ |
| Schenkein David P | Director | M Exercise | 2024-11-11 | 2024-11-13 | 47,165 | $18.00 | $849.0K | 68,661 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | M Exercise deriv | 2024-11-07 | 2024-11-12 | 15,558 | — | $0 | 53,379 | SEC↗ |
| SATO VICKI L | Director | S Sale | 2024-11-07 | 2024-11-12 | 1,020 | $30.00 | $30.6K | 111,056 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | M Exercise | 2024-11-07 | 2024-11-12 | 15,558 | $5.28 | $82.1K | 193,624 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2024-11-07 | 2024-11-12 | 300 | $31.29 | $9.4K | 178,066 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2024-11-07 | 2024-11-12 | 2,925 | $30.72 | $89.9K | 178,366 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2024-11-07 | 2024-11-12 | 12,333 | $29.68 | $366.0K | 181,291 | SEC↗ |
| SATO VICKI L | Director | S Sale | 2024-11-01 | 2024-11-05 | 3,080 | $27.07 | $83.4K | 112,076 | SEC↗ |
| Watts Ryan J. | President and CEO | M Exercise deriv | 2024-10-18 | 2024-10-22 | 40,000 | — | $0 | 1,078,091 | SEC↗ |
| Watts Ryan J. | President and CEO | S Sale | 2024-10-18 | 2024-10-22 | 40,000 | $27.69 | $1.11M | 235,807 | SEC↗ |
| Watts Ryan J. | President and CEO | M Exercise | 2024-10-18 | 2024-10-22 | 40,000 | $0.68 | $27.2K | 275,807 | SEC↗ |
| Krognes Steve E. | Director | S Sale | 2024-09-30 | 2024-10-02 | 30,000 | $29.03 | $870.9K | 29,096 | SEC↗ |
| SATO VICKI L | Director | S Sale | 2024-09-13 | 2024-09-16 | 1,020 | $30.00 | $30.6K | 115,156 | SEC↗ |
| SATO VICKI L | Director | S Sale | 2024-09-03 | 2024-09-04 | 100 | $25.37 | $2.5K | 116,176 | SEC↗ |
| SATO VICKI L | Director | S Sale | 2024-09-03 | 2024-09-04 | 2,980 | $24.99 | $74.5K | 116,276 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2024-08-21 | 2024-08-22 | 5,907 | $24.96 | $147.4K | 118,810 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2024-08-21 | 2024-08-22 | 14,098 | $24.41 | $344.1K | 124,717 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2024-08-21 | 2024-08-22 | 2,547 | $24.78 | $63.1K | 178,066 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2024-08-20 | 2024-08-22 | 2,453 | $23.79 | $58.4K | 138,815 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2024-08-20 | 2024-08-22 | 2,453 | $23.79 | $58.4K | 183,966 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2024-08-20 | 2024-08-22 | 3,353 | $23.54 | $78.9K | 180,613 | SEC↗ |
| Krognes Steve E. | Director | S Sale | 2024-08-20 | 2024-08-22 | 1,727 | $23.79 | $41.1K | 32,677 | SEC↗ |
| Watts Ryan J. | President and CEO | S Sale | 2024-08-20 | 2024-08-22 | 2,260 | $23.79 | $53.8K | 235,807 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2024-08-13 | 2024-08-15 | 2,337 | $22.89 | $53.5K | 141,268 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2024-08-13 | 2024-08-15 | 2,272 | $22.89 | $52.0K | 186,419 | SEC↗ |
| SATO VICKI L | Director | S Sale | 2024-07-01 | 2024-07-03 | 2,980 | $22.12 | $65.9K | 119,356 | SEC↗ |
| SATO VICKI L | Director | S Sale | 2024-07-01 | 2024-07-03 | 100 | $22.86 | $2.3K | 119,256 | SEC↗ |
| Krognes Steve E. | Director | S Sale | 2024-07-01 | 2024-07-03 | 29,900 | $22.12 | $661.4K | 34,504 | SEC↗ |
| Krognes Steve E. | Director | S Sale | 2024-07-01 | 2024-07-03 | 100 | $22.80 | $2.3K | 34,404 | SEC↗ |
| Krognes Steve E. | Director | S Sale | 2024-06-13 | 2024-07-03 | 688 | $21.79 | $15.0K | 52,620 | SEC↗ |
| Cook Jennifer E. | Director | S Sale | 2024-06-06 | 2024-06-10 | 1,458 | $21.73 | $31.7K | 20,038 | SEC↗ |
| Klein Peter S | Director | A Award deriv | 2024-05-31 | 2024-06-04 | 17,901 | — | $0 | 17,901 | SEC↗ |
| Harris Erik | Director | A Award deriv | 2024-05-31 | 2024-06-04 | 17,901 | — | $0 | 17,901 | SEC↗ |
| FLATLEY JAY T | Director | A Award deriv | 2024-05-31 | 2024-06-04 | 17,901 | — | $0 | 17,901 | SEC↗ |
| Schenkein David P | Director | A Award deriv | 2024-05-31 | 2024-06-04 | 17,901 | — | $0 | 17,901 | SEC↗ |
| Cook Jennifer E. | Director | A Award deriv | 2024-05-31 | 2024-06-04 | 17,901 | — | $0 | 17,901 | SEC↗ |
| SATO VICKI L | Director | A Award deriv | 2024-05-31 | 2024-06-04 | 17,901 | — | $0 | 17,901 | SEC↗ |
| Tessier-Lavigne Marc | Director | A Award deriv | 2024-05-31 | 2024-06-04 | 17,901 | — | $0 | 17,901 | SEC↗ |
| Thornberry Nancy | Director | A Award deriv | 2024-05-31 | 2024-06-04 | 17,901 | — | $0 | 17,901 | SEC↗ |
| Krognes Steve E. | Director | A Award deriv | 2024-05-31 | 2024-06-04 | 17,901 | — | $0 | 17,901 | SEC↗ |
| Klein Peter S | Director | A Award | 2024-05-31 | 2024-06-04 | 5,967 | — | $0 | 21,496 | SEC↗ |
| Harris Erik | Director | A Award | 2024-05-31 | 2024-06-04 | 5,967 | — | $0 | 17,052 | SEC↗ |
| FLATLEY JAY T | Director | A Award | 2024-05-31 | 2024-06-04 | 5,967 | — | $0 | 10,183 | SEC↗ |
| Schenkein David P | Director | A Award | 2024-05-31 | 2024-06-04 | 5,967 | — | $0 | 21,496 | SEC↗ |
| Cook Jennifer E. | Director | A Award | 2024-05-31 | 2024-06-04 | 5,967 | — | $0 | 21,496 | SEC↗ |
| SATO VICKI L | Director | A Award | 2024-05-31 | 2024-06-04 | 5,967 | — | $0 | 122,336 | SEC↗ |
| Tessier-Lavigne Marc | Director | A Award | 2024-05-31 | 2024-06-04 | 5,967 | — | $0 | 1,880,539 | SEC↗ |
| Thornberry Nancy | Director | A Award | 2024-05-31 | 2024-06-04 | 5,967 | — | $0 | 18,680 | SEC↗ |
| Krognes Steve E. | Director | A Award | 2024-05-31 | 2024-06-04 | 5,967 | — | $0 | 53,308 | SEC↗ |
| SATO VICKI L | Director | S Sale | 2024-05-15 | 2024-05-17 | 1,674 | $20.39 | $34.1K | 116,369 | SEC↗ |
| SATO VICKI L | Director | S Sale | 2024-04-15 | 2024-04-17 | 1,666 | $18.29 | $30.5K | 118,043 | SEC↗ |
| Krognes Steve E. | Director | S Sale | 2024-04-01 | 2024-04-02 | 92,500 | $20.50 | $1.90M | 47,341 | SEC↗ |
| Watts Ryan J. | President and CEO | G Gift | 2024-03-29 | 2024-03-29 | 40,000 | — | $0 | 2,202,604 | SEC↗ |
| SATO VICKI L | Director | S Sale | 2024-03-15 | 2024-03-19 | 1,666 | $20.10 | $33.5K | 119,709 | SEC↗ |
| SATO VICKI L | Director | S Sale | 2024-02-15 | 2024-02-20 | 1,666 | $18.37 | $30.6K | 121,375 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2024-02-14 | 2024-02-15 | 20,128 | $17.66 | $355.5K | 187,341 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2024-02-14 | 2024-02-15 | 1,405 | $17.79 | $25.0K | 143,605 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2024-02-13 | 2024-02-15 | 2,716 | $17.29 | $47.0K | 207,469 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2024-02-13 | 2024-02-15 | 2,784 | $17.29 | $48.1K | 145,010 | SEC↗ |
| Watts Ryan J. | President and CEO | S Sale | 2024-02-13 | 2024-02-15 | 9,589 | $17.29 | $165.8K | 238,067 | SEC↗ |
| Krognes Steve E. | Director | S Sale | 2024-02-13 | 2024-02-15 | 2,750 | $17.29 | $47.5K | 139,841 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | M Exercise deriv | 2024-02-08 | 2024-02-12 | 50,000 | — | $0 | 145,078 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | M Exercise | 2024-02-08 | 2024-02-12 | 50,000 | $0.68 | $34.0K | 210,185 | SEC↗ |
| SATO VICKI L | Director | S Sale | 2024-01-16 | 2024-01-18 | 1,666 | $18.42 | $30.7K | 123,041 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2024-01-10 | 2024-01-12 | 4,668 | $19.02 | $88.8K | 147,794 | SEC↗ |
| Watts Ryan J. | President and CEO | S Sale | 2024-01-09 | 2024-01-11 | 7,818 | $19.78 | $154.6K | 2,268,363 | SEC↗ |
| Watts Ryan J. | President and CEO | S Sale | 2024-01-05 | 2024-01-09 | 17,483 | $19.43 | $339.7K | 2,276,181 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2024-01-05 | 2024-01-09 | 9,972 | $19.43 | $193.8K | 539,307 | SEC↗ |
| Krognes Steve E. | Director | S Sale | 2024-01-05 | 2024-01-09 | 3,208 | $19.43 | $62.3K | 142,591 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2024-01-05 | 2024-01-09 | 9,972 | $19.43 | $193.8K | 198,777 | SEC↗ |
| Watts Ryan J. | President and CEO | A Award deriv | 2024-01-03 | 2024-01-05 | 268,560 | — | $0 | 268,560 | SEC↗ |
| Ho Carole | Chief Medical Officer | A Award deriv | 2024-01-03 | 2024-01-05 | 161,160 | — | $0 | 161,160 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | A Award deriv | 2024-01-03 | 2024-01-05 | 161,160 | — | $0 | 161,160 | SEC↗ |
| Watts Ryan J. | President and CEO | A Award | 2024-01-03 | 2024-01-05 | 89,520 | — | $0 | 272,957 | SEC↗ |
| Ho Carole | Chief Medical Officer | A Award | 2024-01-03 | 2024-01-05 | 53,720 | — | $0 | 162,434 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | A Award | 2024-01-03 | 2024-01-05 | 53,720 | — | $0 | 170,157 | SEC↗ |
| SATO VICKI L | Director | S Sale | 2023-12-15 | 2023-12-18 | 1,666 | $23.39 | $39.0K | 124,707 | SEC↗ |
| SATO VICKI L | Director | S Sale | 2023-11-15 | 2023-11-16 | 1,666 | $19.13 | $31.9K | 126,373 | SEC↗ |
| SATO VICKI L | Director | S Sale | 2023-10-16 | 2023-10-18 | 1,666 | $20.66 | $34.4K | 128,039 | SEC↗ |
| SATO VICKI L | Director | S Sale | 2023-09-15 | 2023-09-19 | 40 | $24.35 | $974 | 129,705 | SEC↗ |
| SATO VICKI L | Director | S Sale | 2023-09-15 | 2023-09-19 | 1,626 | $23.60 | $38.4K | 129,745 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2023-08-23 | 2023-08-25 | 2,522 | $23.22 | $58.6K | 182,809 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2023-08-23 | 2023-08-25 | 2,522 | $23.17 | $58.4K | 518,989 | SEC↗ |
| Krognes Steve E. | Director | S Sale | 2023-08-21 | 2023-08-23 | 1,419 | $22.60 | $32.1K | 145,799 | SEC↗ |
| Watts Ryan J. | President and CEO | S Sale | 2023-08-21 | 2023-08-23 | 2,309 | $22.59 | $52.2K | 2,242,604 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2023-08-21 | 2023-08-23 | 2,478 | $22.59 | $56.0K | 521,511 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2023-08-21 | 2023-08-23 | 2,478 | $22.60 | $56.0K | 185,331 | SEC↗ |
| SATO VICKI L | Director | S Sale | 2023-08-15 | 2023-08-17 | 1,666 | $24.30 | $40.5K | 131,371 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2023-08-14 | 2023-08-16 | 2,772 | $23.67 | $65.6K | 518,989 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2023-08-14 | 2023-08-16 | 2,768 | $23.79 | $65.9K | 182,809 | SEC↗ |
| Watts Ryan J. | President and CEO | M Exercise deriv | 2023-08-10 | 2023-08-14 | 2,526 | — | $0 | 1,118,091 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2023-08-10 | 2023-08-14 | 2,853 | $24.18 | $69.0K | 521,761 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2023-08-10 | 2023-08-14 | 2,857 | $24.15 | $69.0K | 185,577 | SEC↗ |
| Watts Ryan J. | President and CEO | S Sale | 2023-08-10 | 2023-08-14 | 2,526 | $25.03 | $63.2K | 2,239,913 | SEC↗ |
| Watts Ryan J. | President and CEO | M Exercise | 2023-08-10 | 2023-08-14 | 2,526 | $0.68 | $1.7K | 2,242,439 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2023-07-18 | 2023-07-19 | 9,702 | $30.01 | $291.2K | 518,989 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | M Exercise deriv | 2023-07-17 | 2023-07-19 | 10,000 | — | $0 | 68,937 | SEC↗ |
| SATO VICKI L | Director | S Sale | 2023-07-17 | 2023-07-19 | 1,666 | $29.60 | $49.3K | 133,037 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | M Exercise | 2023-07-17 | 2023-07-19 | 10,000 | $5.28 | $52.8K | 538,691 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2023-07-17 | 2023-07-19 | 10,000 | $29.60 | $296.0K | 528,691 | SEC↗ |
| SATO VICKI L | Director | S Sale | 2023-06-28 | 2023-06-30 | 1,114 | $29.98 | $33.4K | 134,703 | SEC↗ |
| SATO VICKI L | Director | S Sale | 2023-06-28 | 2023-06-30 | 552 | $29.55 | $16.3K | 135,817 | SEC↗ |
| Watts Ryan J. | President and CEO | M Exercise deriv | 2023-06-16 | 2023-06-20 | 50,000 | — | $0 | 1,120,617 | SEC↗ |
| Watts Ryan J. | President and CEO | S Sale | 2023-06-16 | 2023-06-20 | 50,000 | $31.40 | $1.57M | 2,239,913 | SEC↗ |
| Watts Ryan J. | President and CEO | M Exercise | 2023-06-16 | 2023-06-20 | 50,000 | $0.68 | $34.0K | 2,289,913 | SEC↗ |
| SATO VICKI L | Director | A Award deriv | 2023-06-01 | 2023-06-05 | 12,649 | — | $0 | 12,649 | SEC↗ |
| Cole Douglas G. | Director | A Award deriv | 2023-06-01 | 2023-06-05 | 12,649 | — | $0 | 12,649 | SEC↗ |
| Harris Erik | Director | A Award deriv | 2023-06-01 | 2023-06-05 | 12,649 | — | $0 | 12,649 | SEC↗ |
| FLATLEY JAY T | Director | A Award deriv | 2023-06-01 | 2023-06-05 | 12,649 | — | $0 | 12,649 | SEC↗ |
| Schenkein David P | Director | A Award deriv | 2023-06-01 | 2023-06-05 | 12,649 | — | $0 | 12,649 | SEC↗ |
| Cook Jennifer E. | Director | A Award deriv | 2023-06-01 | 2023-06-05 | 12,649 | — | $0 | 12,649 | SEC↗ |
| Klein Peter S | Director | A Award deriv | 2023-06-01 | 2023-06-05 | 12,649 | — | $0 | 12,649 | SEC↗ |
| Tessier-Lavigne Marc | Director | A Award deriv | 2023-06-01 | 2023-06-05 | 12,649 | — | $0 | 12,649 | SEC↗ |
| Krognes Steve E. | Director | A Award deriv | 2023-06-01 | 2023-06-05 | 12,649 | — | $0 | 12,649 | SEC↗ |
| Thornberry Nancy | Director | A Award deriv | 2023-06-01 | 2023-06-05 | 12,649 | — | $0 | 12,649 | SEC↗ |
| SATO VICKI L | Director | A Award | 2023-06-01 | 2023-06-05 | 4,216 | — | $0 | 136,369 | SEC↗ |
| Cole Douglas G. | Director | A Award | 2023-06-01 | 2023-06-05 | 4,216 | — | $0 | 26,564 | SEC↗ |
| Harris Erik | Director | A Award | 2023-06-01 | 2023-06-05 | 4,216 | — | $0 | 11,085 | SEC↗ |
| FLATLEY JAY T | Director | A Award | 2023-06-01 | 2023-06-05 | 4,216 | — | $0 | 340,529 | SEC↗ |
| Schenkein David P | Director | A Award | 2023-06-01 | 2023-06-05 | 4,216 | — | $0 | 15,529 | SEC↗ |
| Cook Jennifer E. | Director | A Award | 2023-06-01 | 2023-06-05 | 4,216 | — | $0 | 15,529 | SEC↗ |
| Klein Peter S | Director | A Award | 2023-06-01 | 2023-06-05 | 4,216 | — | $0 | 15,529 | SEC↗ |
| Tessier-Lavigne Marc | Director | A Award | 2023-06-01 | 2023-06-05 | 4,216 | — | $0 | 1,874,572 | SEC↗ |
| Krognes Steve E. | Director | A Award | 2023-06-01 | 2023-06-05 | 4,216 | — | $0 | 147,218 | SEC↗ |
| Thornberry Nancy | Director | A Award | 2023-06-01 | 2023-06-05 | 4,216 | — | $0 | 12,713 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | M Exercise deriv | 2023-05-15 | 2023-05-17 | 10,000 | — | $0 | 78,937 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2023-05-15 | 2023-05-17 | 800 | $29.23 | $23.4K | 528,691 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2023-05-15 | 2023-05-17 | 9,200 | $28.55 | $262.7K | 529,491 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | M Exercise | 2023-05-15 | 2023-05-17 | 10,000 | $5.28 | $52.8K | 538,691 | SEC↗ |
| Watts Ryan J. | President and CEO | M Exercise deriv | 2023-04-21 | 2023-04-24 | 24,800 | — | $0 | 1,170,617 | SEC↗ |
| Watts Ryan J. | President and CEO | S Sale | 2023-04-21 | 2023-04-24 | 24,800 | $25.15 | $623.7K | 2,239,913 | SEC↗ |
| Watts Ryan J. | President and CEO | M Exercise | 2023-04-21 | 2023-04-24 | 24,800 | $0.68 | $16.9K | 2,264,713 | SEC↗ |
| Watts Ryan J. | President and CEO | M Exercise deriv | 2023-04-20 | 2023-04-24 | 200 | — | $0 | 1,195,417 | SEC↗ |
| Watts Ryan J. | President and CEO | M Exercise | 2023-04-20 | 2023-04-24 | 200 | $0.68 | $136 | 2,240,113 | SEC↗ |
| Watts Ryan J. | President and CEO | S Sale | 2023-04-20 | 2023-04-24 | 200 | $25.00 | $5.0K | 2,239,913 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | M Exercise deriv | 2023-04-13 | 2023-04-14 | 4,898 | — | $0 | 88,937 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2023-04-13 | 2023-04-14 | 4,898 | $25.04 | $122.6K | 528,691 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | M Exercise | 2023-04-13 | 2023-04-14 | 4,898 | $5.28 | $25.9K | 533,589 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | M Exercise deriv | 2023-04-12 | 2023-04-14 | 5,102 | — | $0 | 93,835 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | M Exercise | 2023-04-12 | 2023-04-14 | 5,102 | $5.28 | $26.9K | 533,793 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2023-04-12 | 2023-04-14 | 5,102 | $25.04 | $127.8K | 528,691 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2023-02-15 | 2023-02-17 | 1,476 | $29.40 | $43.4K | 182,809 | SEC↗ |
| Watts Ryan J. | President and CEO | M Exercise deriv | 2023-02-13 | 2023-02-15 | 25,000 | — | $0 | 1,195,617 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | M Exercise deriv | 2023-02-13 | 2023-02-15 | 25,000 | — | $0 | 195,078 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2023-02-13 | 2023-02-14 | 2,548 | $30.10 | $76.7K | 184,285 | SEC↗ |
| Watts Ryan J. | President and CEO | S Sale | 2023-02-13 | 2023-02-15 | 8,815 | $30.09 | $265.2K | 2,239,913 | SEC↗ |
| Watts Ryan J. | President and CEO | S Sale | 2023-02-13 | 2023-02-15 | 25,000 | $30.08 | $752.0K | 2,239,913 | SEC↗ |
| Watts Ryan J. | President and CEO | M Exercise | 2023-02-13 | 2023-02-15 | 25,000 | $0.68 | $17.0K | 2,264,913 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | M Exercise | 2023-02-13 | 2023-02-15 | 25,000 | $0.68 | $17.0K | 524,902 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2023-02-13 | 2023-02-15 | 3,497 | $30.09 | $105.2K | 528,691 | SEC↗ |
| Krognes Steve E. | Director | S Sale | 2023-02-13 | 2023-02-15 | 2,119 | $30.10 | $63.8K | 143,002 | SEC↗ |
| Watts Ryan J. | President and CEO | M Exercise deriv | 2023-02-10 | 2023-02-13 | 25,000 | — | $0 | 1,220,617 | SEC↗ |
| Watts Ryan J. | President and CEO | S Sale | 2023-02-10 | 2023-02-13 | 25,000 | $29.10 | $727.5K | 2,229,031 | SEC↗ |
| Watts Ryan J. | President and CEO | M Exercise | 2023-02-10 | 2023-02-13 | 25,000 | $0.68 | $17.0K | 2,254,031 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2023-02-10 | 2023-02-14 | 818 | $29.80 | $24.4K | 179,365 | SEC↗ |
| Watts Ryan J. | President and CEO | S Sale | 2023-02-09 | 2023-02-13 | 3,433 | $30.59 | $105.0K | 2,229,031 | SEC↗ |
| Krognes Steve E. | Director | S Sale | 2023-02-08 | 2023-02-10 | 1,377 | $30.88 | $42.5K | 145,121 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2023-02-08 | 2023-02-10 | 1,521 | $30.89 | $47.0K | 499,902 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2023-02-08 | 2023-02-10 | 1,521 | $30.88 | $47.0K | 180,183 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | M Exercise deriv | 2023-01-17 | 2023-01-19 | 10,000 | — | $0 | 98,937 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2023-01-17 | 2023-01-19 | 9,886 | $29.53 | $291.9K | 497,287 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2023-01-17 | 2023-01-19 | 114 | $29.87 | $3.4K | 497,173 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | M Exercise | 2023-01-17 | 2023-01-19 | 10,000 | $5.28 | $52.8K | 507,173 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2023-01-09 | 2023-01-10 | 1,459 | $28.48 | $41.6K | 177,454 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2023-01-06 | 2023-01-09 | 1,451 | $28.67 | $41.6K | 178,913 | SEC↗ |
| Watts Ryan J. | President and CEO | S Sale | 2023-01-05 | 2023-01-09 | 4,800 | $28.44 | $136.5K | 2,223,664 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2023-01-05 | 2023-01-09 | 2,636 | $28.44 | $75.0K | 497,173 | SEC↗ |
| Krognes Steve E. | Director | S Sale | 2023-01-05 | 2023-01-09 | 2,970 | $28.44 | $84.5K | 146,498 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2023-01-05 | 2023-01-09 | 2,636 | $28.44 | $75.0K | 180,364 | SEC↗ |
| Watts Ryan J. | President and CEO | S Sale | 2023-01-04 | 2023-01-05 | 5,029 | $28.73 | $144.5K | 2,213,464 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2023-01-04 | 2023-01-05 | 2,912 | $28.70 | $83.6K | 149,828 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2023-01-04 | 2023-01-05 | 2,913 | $28.69 | $83.6K | 175,500 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2023-01-04 | 2023-01-09 | 2,912 | $28.70 | $83.6K | 492,309 | SEC↗ |
| Watts Ryan J. | President and CEO | A Award deriv | 2023-01-03 | 2023-01-05 | 246,720 | — | $0 | 246,720 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | A Award deriv | 2023-01-03 | 2023-01-05 | 123,360 | — | $0 | 123,360 | SEC↗ |
| Ho Carole | Chief Medical Officer | A Award deriv | 2023-01-03 | 2023-01-05 | 123,360 | — | $0 | 123,360 | SEC↗ |
| Watts Ryan J. | President and CEO | A Award | 2023-01-03 | 2023-01-05 | 82,240 | — | $0 | 231,934 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | A Award | 2023-01-03 | 2023-01-05 | 41,120 | — | $0 | 157,578 | SEC↗ |
| Ho Carole | Chief Medical Officer | A Award | 2023-01-03 | 2023-01-05 | 41,120 | — | $0 | 138,967 | SEC↗ |
| Tessier-Lavigne Marc | Director | S Sale | 2022-11-23 | 2022-11-28 | 20,000 | $30.48 | $609.6K | 1,870,356 | SEC↗ |
| Tessier-Lavigne Marc | Director | S Sale | 2022-11-02 | 2022-11-03 | 11,252 | $30.33 | $341.3K | 1,890,356 | SEC↗ |
| Tessier-Lavigne Marc | Director | S Sale | 2022-11-01 | 2022-11-03 | 8,748 | $30.20 | $264.2K | 1,901,608 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | M Exercise deriv | 2022-10-07 | 2022-10-12 | 20,000 | — | $0 | 220,078 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | M Exercise | 2022-10-07 | 2022-10-12 | 20,000 | $0.68 | $13.6K | 487,471 | SEC↗ |
| Tessier-Lavigne Marc | Director | S Sale | 2022-09-28 | 2022-09-30 | 15,577 | $30.74 | $478.8K | 1,914,779 | SEC↗ |
| Tessier-Lavigne Marc | Director | S Sale | 2022-09-28 | 2022-09-30 | 4,423 | $31.08 | $137.5K | 1,910,356 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2022-08-23 | 2022-08-25 | 2,424 | $31.98 | $77.5K | 170,663 | SEC↗ |
| Tessier-Lavigne Marc | Director | S Sale | 2022-08-23 | 2022-08-25 | 100 | $32.43 | $3.2K | 1,930,356 | SEC↗ |
| Tessier-Lavigne Marc | Director | S Sale | 2022-08-23 | 2022-08-25 | 19,900 | $31.61 | $629.0K | 1,930,456 | SEC↗ |
| Ho Carole | Chief Medical Officer | S Sale | 2022-08-19 | 2022-08-23 | 2,576 | $33.22 | $85.6K | 173,087 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | S Sale | 2022-08-19 | 2022-08-23 | 2,576 | $33.22 | $85.6K | 467,471 | SEC↗ |
| Krognes Steve E. | Director | S Sale | 2022-08-19 | 2022-08-23 | 2,253 | $33.22 | $74.8K | 149,468 | SEC↗ |
| Watts Ryan J. | President and CEO | S Sale | 2022-08-19 | 2022-08-23 | 2,404 | $33.22 | $79.9K | 2,202,993 | SEC↗ |
| Schuth Alexander O. | COFO and Secretary | A Award | 2022-08-09 | 2022-08-11 | 22,500 | — | $0 | 121,458 | SEC↗ |
| Ho Carole | Chief Medical Officer | A Award | 2022-08-09 | 2022-08-11 | 22,500 | — | $0 | 110,597 | SEC↗ |
| Tessier-Lavigne Marc | Director | S Sale | 2022-07-25 | 2022-07-27 | 200 | $36.15 | $7.2K | 1,950,356 | SEC↗ |
| Tessier-Lavigne Marc | Director | S Sale | 2022-07-25 | 2022-07-27 | 19,800 | $35.60 | $704.9K | 1,950,556 | SEC↗ |
| Krognes Steve E. | Director | M Exercise deriv | 2022-07-19 | 2022-07-21 | 62,500 | — | $0 | 0 | SEC↗ |
| Krognes Steve E. | Director | M Exercise | 2022-07-19 | 2022-07-21 | 62,500 | $0.68 | $42.5K | 151,721 | SEC↗ |
| Tessier-Lavigne Marc | Director | D To issuer | 2022-06-24 | 2022-06-27 | 39,984 | $30.53 | $1.22M | 1,977,122 | SEC↗ |
| Tessier-Lavigne Marc | Director | D To issuer | 2022-06-24 | 2022-06-27 | 6,766 | $31.08 | $210.3K | 1,970,356 | SEC↗ |
| Tessier-Lavigne Marc | Director | D To issuer | 2022-06-23 | 2022-06-27 | 13,250 | $31.10 | $412.1K | 2,017,106 | SEC↗ |
| Thornberry Nancy | Director | A Award deriv | 2022-06-02 | 2022-06-06 | 17,959 | — | $0 | 17,959 | SEC↗ |
| FLATLEY JAY T | Director | A Award deriv | 2022-06-02 | 2022-06-06 | 17,959 | — | $0 | 17,959 | SEC↗ |
| Cook Jennifer E. | Director | A Award deriv | 2022-06-02 | 2022-06-06 | 17,959 | — | $0 | 17,959 | SEC↗ |
| SATO VICKI L | Director | A Award deriv | 2022-06-02 | 2022-06-06 | 17,959 | — | $0 | 17,959 | SEC↗ |
| Cole Douglas G. | Director | A Award deriv | 2022-06-02 | 2022-06-06 | 17,959 | — | $0 | 17,959 | SEC↗ |