HPTX

HYPERION THERAPEUTICS INCCIK 1386858 ☆ Sign in to watch Congress trades

Open-mkt buys · 90d

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0 trades · 0 insiders

Open-mkt sales · 90d

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0 trades · 0 insiders

Net · 90d

Insiders on file

AI insights for HPTX PRO

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AI insights for HPTX

Insider sentiment score with a plain-English explanation, conviction score on every buy, and how the stock performed 30 and 90 days after past insider buys.

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Daily buy vs sell · 90 days

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Insiders

Insider	Role	Trades	Bought	Sold	Last trade
Gould Ashley C.	SVP Govt Aff & Chief Legal Ofc	11	$0	$0	2015-05-07
Holles Natalie C.	SVP, Corp & Business Dev	13	$0	$0	2015-05-07
Nash Christine A	SVP & Chief Commercial Officer	46	$0	$1.53M	2015-05-07
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	55	$0	$896.4K	2015-05-07
Hansen Bo Jesper	Director	8	$0	$0	2015-05-07
Salehizadeh Bijan	Director	8	$0	$0	2015-05-07
Nunn Jason Raleigh	Director	10	$0	$0	2015-05-07
Farrow Jeffrey S	CFO & Secretary	25	$0	$0	2015-05-07
NEA Partners 12, Limited Partnership	10% Owner	4	$0	$0	2015-05-07
Schroeder Theodore R	Director	5	$0	$0	2015-05-07
Buatois Eric	10% Owner	1	$0	$0	2015-05-07
DRANT RYAN D	10% Owner	34	$5.00M	$30.5K	2015-05-07
Santel Donald J	CEO & President	23	$0	$0	2015-05-07
Zoth Lota S.	Director	9	$0	$0	2015-05-07
BASKETT FOREST	10% Owner	32	$5.00M	$37.0K	2015-05-07
KOLLURI KRISHNA KITTU	10% Owner	34	$5.00M	$3.3K	2015-05-07
HEALY JAMES	Director, 10% Owner	38	$5.63M	$11.57M	2015-05-07
SANDELL SCOTT D	10% Owner	32	$5.00M	$7.9K	2015-05-07
KERINS PATRICK J	10% Owner	30	$5.00M	$0	2015-05-07
BARRETT M JAMES	10% Owner	34	$5.00M	$38.4K	2015-05-07
WELCH DANIEL G	Director	8	$0	$0	2015-05-07
BARRIS PETER J	10% Owner	34	$5.00M	$30.5K	2015-05-07
New Enterprise Associates 12, Limited Partnership	10% Owner	1	$0	$0	2014-06-05
Sofinnova Management VII, L.L.C.	10% Owner	1	$0	$11.57M	2014-06-04
Dickinson Klara	SVP Reg. Affairs & Compliance	5	$0	$0	2014-03-11
POWELL MICHAEL	10% Owner	3	$0	$709.2K	2014-03-04
Bay City Capital Fund V Co-Investment Fund, L.P.	10% Owner	18	$0	$0	2013-10-18
Highland Capital Partners VII-C LP	10% Owner	16	$0	$619.0K	2013-09-20
Highland Capital Partners VII LP	10% Owner	68	$980.7K	$404.2K	2013-09-18
HIGHLAND CAPITAL PARTNERS VII-B L P	10% Owner	52	$19.3K	$1.42M	2013-09-16
Highland Management Partners VII Limited Partnership	10% Owner	12	$0	$1.56M	2013-09-11
BAY CITY CAPITAL LLC	10% Owner	6	$0	$0	2013-07-19
Bay City Capital Management V LLC	10% Owner	34	$0	$0	2013-07-10
Bay City Capital Fund V, L.P.	10% Owner	8	$0	$3.35M	2013-05-30
GRYSKA DAVID W	Director	1	$0	$0	2013-04-15
Aggarwal Gaurav	Director	1	$50.0K	$0	2012-07-31
Panorama Capital, L.P.	10% Owner	22	$5.50M	$0	2012-07-31
NEA 12 GP, LLC	10% Owner	24	$5.00M	$0	2012-07-31
PERRY MARK W	10% Owner	24	$5.00M	$0	2012-07-31
KRAMLICH C RICHARD	10% Owner	24	$5.00M	$0	2012-07-31
NEWHALL CHARLES W III	10% Owner	24	$5.00M	$0	2012-07-31

Trade history

Insider	Role	Code	Trade	Filed	Shares	Price	Value	Owned after
WELCH DANIEL G	Director	D To issuer deriv	2015-05-07	2015-05-08	4,869	$46.00	$224.0K	0	SEC↗
WELCH DANIEL G	Director	D To issuer deriv	2015-05-07	2015-05-08	9,800	$46.00	$450.8K	0	SEC↗
WELCH DANIEL G	Director	D To issuer deriv	2015-05-07	2015-05-08	20,000	$46.00	$920.0K	0	SEC↗
Farrow Jeffrey S	CFO	D To issuer deriv	2015-05-07	2015-05-08	32,500	$46.00	$1.50M	0	SEC↗
Farrow Jeffrey S	CFO	D To issuer deriv	2015-05-07	2015-05-08	23,346	$46.00	$1.07M	0	SEC↗
Farrow Jeffrey S	CFO	D To issuer deriv	2015-05-07	2015-05-08	14,371	$46.00	$661.1K	0	SEC↗
Farrow Jeffrey S	CFO	D To issuer deriv	2015-05-07	2015-05-08	39,500	$46.00	$1.82M	0	SEC↗
Farrow Jeffrey S	CFO	D To issuer deriv	2015-05-07	2015-05-08	38,000	$46.00	$1.75M	0	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	D To issuer deriv	2015-05-07	2015-05-08	39,500	$46.00	$1.82M	0	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	D To issuer deriv	2015-05-07	2015-05-08	50,000	$46.00	$2.30M	0	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	D To issuer deriv	2015-05-07	2015-05-08	32,500	$46.00	$1.50M	0	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	D To issuer deriv	2015-05-07	2015-05-08	6,881	$46.00	$316.5K	0	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	D To issuer deriv	2015-05-07	2015-05-08	91	—	$0	0	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	D To issuer deriv	2015-05-07	2015-05-08	18	—	$0	0	SEC↗
Salehizadeh Bijan	Director	D To issuer deriv	2015-05-07	2015-05-08	4,105	$46.00	$188.8K	0	SEC↗
Salehizadeh Bijan	Director	D To issuer deriv	2015-05-07	2015-05-08	11,855	$46.00	$545.3K	0	SEC↗
Salehizadeh Bijan	Director	D To issuer deriv	2015-05-07	2015-05-08	9,800	$46.00	$450.8K	0	SEC↗
Salehizadeh Bijan	Director	D To issuer deriv	2015-05-07	2015-05-08	4,869	$46.00	$224.0K	0	SEC↗
Hansen Bo Jesper	Director	D To issuer deriv	2015-05-07	2015-05-08	11,855	$46.00	$545.3K	0	SEC↗
Hansen Bo Jesper	Director	D To issuer deriv	2015-05-07	2015-05-08	4,105	$46.00	$188.8K	0	SEC↗
Hansen Bo Jesper	Director	D To issuer deriv	2015-05-07	2015-05-08	4,869	$46.00	$224.0K	0	SEC↗
Hansen Bo Jesper	Director	D To issuer deriv	2015-05-07	2015-05-08	9,800	$46.00	$450.8K	0	SEC↗
Santel Donald J	CEO & President	D To issuer deriv	2015-05-07	2015-05-08	70,000	$46.00	$3.22M	0	SEC↗
Santel Donald J	CEO & President	D To issuer deriv	2015-05-07	2015-05-08	111,000	$46.00	$5.11M	0	SEC↗
Santel Donald J	CEO & President	D To issuer deriv	2015-05-07	2015-05-08	169	—	$0	0	SEC↗
Santel Donald J	CEO & President	D To issuer deriv	2015-05-07	2015-05-08	143,000	$46.00	$6.58M	0	SEC↗
Santel Donald J	CEO & President	D To issuer deriv	2015-05-07	2015-05-08	88,547	$46.00	$4.07M	0	SEC↗
Santel Donald J	CEO & President	D To issuer deriv	2015-05-07	2015-05-08	303,133	$46.00	$13.94M	0	SEC↗
Santel Donald J	CEO & President	D To issuer deriv	2015-05-07	2015-05-08	6,648	$46.00	$305.8K	0	SEC↗
Holles Natalie C.	SVP, Business Development	D To issuer deriv	2015-05-07	2015-05-08	24,000	$46.00	$1.10M	0	SEC↗
Holles Natalie C.	SVP, Business Development	D To issuer deriv	2015-05-07	2015-05-08	63,000	$46.00	$2.90M	0	SEC↗
Holles Natalie C.	SVP, Business Development	D To issuer deriv	2015-05-07	2015-05-08	21,000	$46.00	$966.0K	0	SEC↗
Holles Natalie C.	SVP, Business Development	D To issuer deriv	2015-05-07	2015-05-08	29,000	$46.00	$1.33M	0	SEC↗
Zoth Lota S.	Director	D To issuer deriv	2015-05-07	2015-05-08	11,855	$46.00	$545.3K	0	SEC↗
Zoth Lota S.	Director	D To issuer deriv	2015-05-07	2015-05-08	4,105	$46.00	$188.8K	0	SEC↗
Zoth Lota S.	Director	D To issuer deriv	2015-05-07	2015-05-08	14,700	$46.00	$676.2K	0	SEC↗
Zoth Lota S.	Director	D To issuer deriv	2015-05-07	2015-05-08	4,869	$46.00	$224.0K	0	SEC↗
Zoth Lota S.	Director	D To issuer deriv	2015-05-07	2015-05-08	55	—	$0	0	SEC↗
Gould Ashley C.	SVP Govt Aff & Chief Legal O	D To issuer deriv	2015-05-07	2015-05-08	84,000	$46.00	$3.86M	0	SEC↗
Gould Ashley C.	SVP Govt Aff & Chief Legal O	D To issuer deriv	2015-05-07	2015-05-08	26,500	$46.00	$1.22M	0	SEC↗
Gould Ashley C.	SVP Govt Aff & Chief Legal O	D To issuer deriv	2015-05-07	2015-05-08	34,000	$46.00	$1.56M	0	SEC↗
Schroeder Theodore R	Director	D To issuer deriv	2015-05-07	2015-05-08	6,800	$46.00	$312.8K	0	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	D To issuer deriv	2015-05-07	2015-05-08	25,227	$46.00	$1.16M	0	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	D To issuer deriv	2015-05-07	2015-05-08	32,000	$46.00	$1.47M	0	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	D To issuer deriv	2015-05-07	2015-05-08	46,000	$46.00	$2.12M	0	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	D To issuer deriv	2015-05-07	2015-05-08	24,000	$46.00	$1.10M	0	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	D To issuer deriv	2015-05-07	2015-05-08	27	—	$0	0	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	D To issuer deriv	2015-05-07	2015-05-08	191	—	$0	0	SEC↗
HEALY JAMES	Director, 10% Owner	D To issuer deriv	2015-05-07	2015-05-08	4,105	$46.00	$188.8K	0	SEC↗
HEALY JAMES	Director, 10% Owner	D To issuer deriv	2015-05-07	2015-05-08	9,800	$46.00	$450.8K	0	SEC↗
HEALY JAMES	Director, 10% Owner	D To issuer deriv	2015-05-07	2015-05-08	4,869	$46.00	$224.0K	0	SEC↗
Nunn Jason Raleigh	Director	D To issuer deriv	2015-05-07	2015-05-11	11,855	$46.00	$545.3K	0	SEC↗
Nunn Jason Raleigh	Director	D To issuer deriv	2015-05-07	2015-05-11	4,869	$46.00	$224.0K	0	SEC↗
Nunn Jason Raleigh	Director	D To issuer deriv	2015-05-07	2015-05-11	9,800	$46.00	$450.8K	0	SEC↗
Nunn Jason Raleigh	Director	D To issuer deriv	2015-05-07	2015-05-11	4,105	$46.00	$188.8K	0	SEC↗
WELCH DANIEL G	Director	D To issuer	2015-05-07	2015-05-08	2,617	$46.00	$120.4K	0	SEC↗
Farrow Jeffrey S	CFO	U Tender	2015-05-07	2015-05-08	878	$46.00	$40.4K	0	SEC↗
Farrow Jeffrey S	CFO	D To issuer	2015-05-07	2015-05-08	120,777	$46.00	$5.56M	0	SEC↗
Farrow Jeffrey S	CFO	D To issuer	2015-05-07	2015-05-08	22,687	$46.00	$1.04M	0	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	D To issuer	2015-05-07	2015-05-08	25,500	$46.00	$1.17M	0	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	U Tender	2015-05-07	2015-05-08	11,503	$46.00	$529.1K	0	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	D To issuer	2015-05-07	2015-05-08	59,087	$46.00	$2.72M	0	SEC↗
Salehizadeh Bijan	Director	D To issuer	2015-05-07	2015-05-08	2,617	$46.00	$120.4K	0	SEC↗
Hansen Bo Jesper	Director	D To issuer	2015-05-07	2015-05-08	2,617	$46.00	$120.4K	0	SEC↗
Santel Donald J	CEO & President	U Tender	2015-05-07	2015-05-08	10,164	$46.00	$467.5K	0	SEC↗
Santel Donald J	CEO & President	D To issuer	2015-05-07	2015-05-08	292,057	$46.00	$13.43M	0	SEC↗
Santel Donald J	CEO & President	U Tender	2015-05-07	2015-05-08	2,306	$46.00	$106.1K	0	SEC↗
Santel Donald J	CEO & President	D To issuer	2015-05-07	2015-05-08	53,875	$46.00	$2.48M	0	SEC↗
Holles Natalie C.	SVP, Business Development	U Tender	2015-05-07	2015-05-08	702	$46.00	$32.3K	0	SEC↗
Holles Natalie C.	SVP, Business Development	D To issuer	2015-05-07	2015-05-08	17,750	$46.00	$816.5K	0	SEC↗
Zoth Lota S.	Director	D To issuer	2015-05-07	2015-05-08	2,617	$46.00	$120.4K	0	SEC↗
Gould Ashley C.	SVP Govt Aff & Chief Legal O	U Tender	2015-05-07	2015-05-08	801	$46.00	$36.8K	0	SEC↗
Gould Ashley C.	SVP Govt Aff & Chief Legal O	D To issuer	2015-05-07	2015-05-08	21,775	$46.00	$1.00M	0	SEC↗
Schroeder Theodore R	Director	D To issuer	2015-05-07	2015-05-08	3,083	$46.00	$141.8K	0	SEC↗
Schroeder Theodore R	Director	U Tender	2015-05-07	2015-05-08	617	$46.00	$28.4K	0	SEC↗
Buatois Eric	10% Owner	U Tender	2015-05-07	2015-05-08	1,939,474	$46.00	$89.22M	0	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	D To issuer	2015-05-07	2015-05-08	18,050	$46.00	$830.3K	0	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	U Tender	2015-05-07	2015-05-08	97,471	$46.00	$4.48M	0	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	D To issuer	2015-05-07	2015-05-08	6,975	$46.00	$320.9K	0	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	U Tender	2015-05-07	2015-05-08	24,448	$46.00	$1.12M	0	SEC↗
HEALY JAMES	Director, 10% Owner	U Tender	2015-05-07	2015-05-08	5,006	$46.00	$230.3K	0	SEC↗
HEALY JAMES	Director, 10% Owner	D To issuer	2015-05-07	2015-05-08	2,617	$46.00	$120.4K	0	SEC↗
HEALY JAMES	Director, 10% Owner	U Tender	2015-05-07	2015-05-08	1,939,474	$46.00	$89.22M	0	SEC↗
NEA Partners 12, Limited Partn	10% Owner	U Tender	2015-05-07	2015-05-11	2,384,221	$46.00	$109.67M	0	SEC↗
Nunn Jason Raleigh	Director	U Tender	2015-05-07	2015-05-11	70	$46.00	$3.2K	0	SEC↗
Nunn Jason Raleigh	Director	D To issuer	2015-05-07	2015-05-11	2,617	$46.00	$120.4K	0	SEC↗
KOLLURI KRISHNA KITTU	10% Owner	U Tender	2015-05-07	2015-05-11	2,384,221	$46.00	$109.67M	0	SEC↗
SANDELL SCOTT D	10% Owner	U Tender	2015-05-07	2015-05-11	2,384,221	$46.00	$109.67M	0	SEC↗
KERINS PATRICK J	10% Owner	U Tender	2015-05-07	2015-05-11	2,384,221	$46.00	$109.67M	0	SEC↗
KERINS PATRICK J	10% Owner	U Tender	2015-05-07	2015-05-11	120	$46.00	$5.5K	0	SEC↗
BARRETT M JAMES	10% Owner	U Tender	2015-05-07	2015-05-11	2,384,221	$46.00	$109.67M	0	SEC↗
BASKETT FOREST	10% Owner	U Tender	2015-05-07	2015-05-11	2,384,221	$46.00	$109.67M	0	SEC↗
BARRIS PETER J	10% Owner	U Tender	2015-05-07	2015-05-11	68	$46.00	$3.1K	0	SEC↗
BARRIS PETER J	10% Owner	U Tender	2015-05-07	2015-05-11	222	$46.00	$10.2K	0	SEC↗
BARRIS PETER J	10% Owner	U Tender	2015-05-07	2015-05-11	2,384,221	$46.00	$109.67M	0	SEC↗
DRANT RYAN D	10% Owner	U Tender	2015-05-07	2015-05-11	30	$46.00	$1.4K	0	SEC↗
DRANT RYAN D	10% Owner	U Tender	2015-05-07	2015-05-11	2,384,221	$46.00	$109.67M	0	SEC↗
DRANT RYAN D	10% Owner	U Tender	2015-05-07	2015-05-11	266	$46.00	$12.2K	0	SEC↗
HEALY JAMES	Director, 10% Owner	G Gift	2015-05-04	2015-05-08	1,087	—	$0	5,333	SEC↗
HEALY JAMES	Director, 10% Owner	G Gift	2015-05-04	2015-05-08	4,348	—	$0	7,507	SEC↗
HEALY JAMES	Director, 10% Owner	G Gift	2015-05-04	2015-05-08	1,087	—	$0	6,420	SEC↗
HEALY JAMES	Director, 10% Owner	G Gift	2015-05-04	2015-05-08	327	—	$0	5,006	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	M Exercise deriv	2015-05-01	2015-05-05	16,157	—	$0	0	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	M Exercise deriv	2015-05-01	2015-05-05	12,709	—	$0	0	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	M Exercise deriv	2015-05-01	2015-05-05	30,221	—	$0	6,881	SEC↗
Farrow Jeffrey S	CFO	M Exercise deriv	2015-05-01	2015-05-05	53,184	—	$0	0	SEC↗
Farrow Jeffrey S	CFO	M Exercise deriv	2015-05-01	2015-05-05	24,630	—	$0	0	SEC↗
Farrow Jeffrey S	CFO	M Exercise deriv	2015-05-01	2015-05-05	17,704	—	$0	23,346	SEC↗
Farrow Jeffrey S	CFO	M Exercise deriv	2015-05-01	2015-05-05	629	—	$0	14,371	SEC↗
Farrow Jeffrey S	CFO	M Exercise deriv	2015-05-01	2015-05-05	24,630	—	$0	0	SEC↗
Santel Donald J	CEO & President	M Exercise deriv	2015-05-01	2015-05-05	33,242	—	$0	6,648	SEC↗
Santel Donald J	CEO & President	M Exercise deriv	2015-05-01	2015-05-05	224,211	—	$0	303,133	SEC↗
Santel Donald J	CEO & President	M Exercise deriv	2015-05-01	2015-05-05	34,604	—	$0	88,547	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise deriv	2015-05-01	2015-05-05	4,789	—	$0	25,227	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise deriv	2015-05-01	2015-05-05	2,186	—	$0	0	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	M Exercise	2015-05-01	2015-05-05	12,709	$4.08	$51.9K	65,869	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	M Exercise	2015-05-01	2015-05-05	16,157	$1.28	$20.7K	53,160	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	M Exercise	2015-05-01	2015-05-05	30,221	$7.31	$220.9K	96,090	SEC↗
Farrow Jeffrey S	CFO	M Exercise	2015-05-01	2015-05-05	17,704	$7.31	$129.4K	143,773	SEC↗
Farrow Jeffrey S	CFO	M Exercise	2015-05-01	2015-05-05	53,184	$4.08	$217.0K	126,069	SEC↗
Farrow Jeffrey S	CFO	M Exercise	2015-05-01	2015-05-05	24,630	$1.28	$31.5K	48,255	SEC↗
Farrow Jeffrey S	CFO	M Exercise	2015-05-01	2015-05-05	24,630	$1.28	$31.5K	72,885	SEC↗
Farrow Jeffrey S	CFO	M Exercise	2015-05-01	2015-05-05	629	$10.95	$6.9K	144,402	SEC↗
Santel Donald J	CEO & President	M Exercise	2015-05-01	2015-05-05	224,211	$1.28	$287.0K	280,689	SEC↗
Santel Donald J	CEO & President	M Exercise	2015-05-01	2015-05-05	33,242	$4.08	$135.6K	313,931	SEC↗
Santel Donald J	CEO & President	M Exercise	2015-05-01	2015-05-05	34,604	$7.31	$253.0K	348,535	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise	2015-05-01	2015-05-05	4,789	$7.31	$35.0K	104,458	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise	2015-05-01	2015-05-05	2,186	$4.08	$8.9K	99,669	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	M Exercise deriv	2015-03-17	2015-03-17	10,000	—	$0	12,709	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	S Sale	2015-03-17	2015-03-17	10,000	$37.56	$375.6K	19,003	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	M Exercise	2015-03-17	2015-03-17	10,000	$4.08	$40.8K	29,003	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	M Exercise deriv	2015-03-12	2015-03-13	10,000	—	$0	22,709	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	S Sale	2015-03-10	2015-03-10	1,450	$30.10	$43.6K	19,003	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	M Exercise	2015-03-10	2015-03-13	10,000	$4.08	$40.8K	29,003	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	S Sale	2015-03-10	2015-03-13	10,000	$35.08	$350.8K	19,003	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	S Sale	2015-03-09	2015-03-10	2,800	$30.00	$84.0K	20,453	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	S Sale	2015-03-09	2015-03-10	5,650	$29.32	$165.7K	23,253	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	S Sale	2015-02-27	2015-03-03	24,996	$29.79	$744.6K	29,252	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	S Sale	2015-02-27	2015-03-03	4,804	$30.43	$146.2K	24,448	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	A Award deriv	2015-02-09	2015-02-10	32,500	—	$0	32,500	SEC↗
Holles Natalie C.	SVP, Business Development	A Award deriv	2015-02-09	2015-02-10	24,000	—	$0	24,000	SEC↗
Farrow Jeffrey S	CFO	A Award deriv	2015-02-09	2015-02-10	32,500	—	$0	32,500	SEC↗
Santel Donald J	CEO & President	A Award deriv	2015-02-09	2015-02-10	70,000	—	$0	70,000	SEC↗
Gould Ashley C.	SVP Govt Aff & Chief Legal O	A Award deriv	2015-02-09	2015-02-10	26,500	—	$0	26,500	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	A Award deriv	2015-02-09	2015-02-10	24,000	—	$0	24,000	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	A Award	2015-02-09	2015-02-10	18,000	—	$0	46,903	SEC↗
Holles Natalie C.	SVP, Business Development	A Award	2015-02-09	2015-02-10	14,000	—	$0	18,452	SEC↗
Farrow Jeffrey S	CFO	A Award	2015-02-09	2015-02-10	18,000	—	$0	23,625	SEC↗
Santel Donald J	CEO & President	A Award	2015-02-09	2015-02-10	40,000	—	$0	56,478	SEC↗
Gould Ashley C.	SVP Govt Aff & Chief Legal O	A Award	2015-02-09	2015-02-10	17,500	—	$0	22,576	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	A Award	2015-02-09	2015-02-10	14,000	—	$0	97,471	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	S Sale	2015-01-20	2015-01-22	2,500	$25.27	$63.2K	28,903	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	S Sale	2015-01-20	2015-01-22	2,500	$24.36	$60.9K	31,403	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	F Tax w/h	2015-01-02	2015-01-05	592	$24.28	$14.4K	81,285	SEC↗
Santel Donald J	CEO & President	F Tax w/h	2015-01-02	2015-01-05	2,022	$24.28	$49.1K	16,478	SEC↗
Gould Ashley C.	SVP Govt Aff & Chief Legal O	F Tax w/h	2015-01-02	2015-01-05	624	$24.28	$15.2K	5,076	SEC↗
Holles Natalie C.	SVP, Business Development	F Tax w/h	2015-01-02	2015-01-05	548	$24.28	$13.3K	4,452	SEC↗
Farrow Jeffrey S	CFO	F Tax w/h	2015-01-02	2015-01-05	685	$24.28	$16.6K	5,625	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	F Tax w/h	2015-01-02	2015-01-05	1,095	$24.28	$26.6K	33,903	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise deriv	2014-12-23	2014-12-24	1,093	—	$0	0	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise deriv	2014-12-23	2014-12-29	1,093	—	$0	2,186	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise	2014-12-23	2014-12-24	1,093	$4.08	$4.5K	98,559	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise deriv	2014-10-20	2014-10-21	2,186	—	$0	3,279	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise deriv	2014-10-20	2014-10-21	2,835	—	$0	30,016	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise	2014-10-20	2014-10-21	2,186	$4.08	$8.9K	99,652	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise	2014-10-20	2014-10-21	2,835	$7.31	$20.7K	97,466	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	M Exercise deriv	2014-10-15	2014-10-17	10,000	—	$0	16,157	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	M Exercise	2014-10-15	2014-10-17	10,000	$1.28	$12.8K	34,998	SEC↗
Schroeder Theodore R	Director	A Award deriv	2014-08-13	2014-08-14	6,800	—	$0	6,800	SEC↗
Schroeder Theodore R	Director	A Award	2014-08-13	2014-08-14	3,700	—	$0	3,700	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	S Sale	2014-07-02	2014-07-03	200	$28.00	$5.6K	37,566	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise deriv	2014-06-18	2014-06-20	1,640	—	$0	5,465	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise deriv	2014-06-18	2014-06-20	3,592	—	$0	32,851	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise deriv	2014-06-18	2014-06-20	1,640	—	$0	5,465	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise deriv	2014-06-18	2014-06-20	3,592	—	$0	32,851	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise	2014-06-18	2014-06-20	3,592	$7.31	$26.3K	92,991	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise	2014-06-18	2014-06-20	1,640	$4.08	$6.7K	94,631	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise	2014-06-18	2014-06-20	1,640	$4.08	$6.7K	94,631	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise	2014-06-18	2014-06-20	3,592	$7.31	$26.3K	92,991	SEC↗
KOLLURI KRISHNA KITTU	10% Owner	S Sale	2014-06-06	2014-06-06	100	$27.19	$2.7K	0	SEC↗
KOLLURI KRISHNA KITTU	10% Owner	S Sale	2014-06-06	2014-06-06	10	$27.19	$272	0	SEC↗
KOLLURI KRISHNA KITTU	10% Owner	S Sale	2014-06-06	2014-06-06	10	$27.19	$272	0	SEC↗
SANDELL SCOTT D	10% Owner	S Sale	2014-06-06	2014-06-09	1,134	—	$0	0	SEC↗
SANDELL SCOTT D	10% Owner	S Sale	2014-06-06	2014-06-09	296	$26.74	$7.9K	0	SEC↗
DRANT RYAN D	10% Owner	S Sale	2014-06-06	2014-06-09	1,134	$26.90	$30.5K	0	SEC↗
BARRETT M JAMES	10% Owner	S Sale	2014-06-06	2014-06-09	1,134	$26.90	$30.5K	0	SEC↗
BARRETT M JAMES	10% Owner	S Sale	2014-06-06	2014-06-09	148	$26.77	$4.0K	0	SEC↗
BARRETT M JAMES	10% Owner	S Sale	2014-06-06	2014-06-09	148	$26.80	$4.0K	0	SEC↗
BASKETT FOREST	10% Owner	S Sale	2014-06-06	2014-06-09	1,134	$26.90	$30.5K	0	SEC↗
BASKETT FOREST	10% Owner	S Sale	2014-06-06	2014-06-09	243	$26.87	$6.5K	0	SEC↗
BARRIS PETER J	10% Owner	S Sale	2014-06-06	2014-06-09	1,134	$26.90	$30.5K	0	SEC↗
New Enterprise Associates 12,	10% Owner	J Other	2014-06-05	2014-06-06	500,000	—	$0	2,384,221	SEC↗
NEA Partners 12, Limited Partn	10% Owner	J Other	2014-06-05	2014-06-06	5,000	—	$0	0	SEC↗
NEA Partners 12, Limited Partn	10% Owner	J Other	2014-06-05	2014-06-06	500,000	—	$0	2,384,221	SEC↗
NEA Partners 12, Limited Partn	10% Owner	J Other	2014-06-05	2014-06-06	5,000	—	$0	5,000	SEC↗
Nunn Jason Raleigh	Director	J Other	2014-06-05	2014-06-06	70	—	$0	70	SEC↗
SANDELL SCOTT D	10% Owner	J Other	2014-06-05	2014-06-06	1,134	—	$0	1,134	SEC↗
SANDELL SCOTT D	10% Owner	J Other	2014-06-05	2014-06-06	296	—	$0	296	SEC↗
SANDELL SCOTT D	10% Owner	J Other	2014-06-05	2014-06-06	5,000	—	$0	0	SEC↗
SANDELL SCOTT D	10% Owner	J Other	2014-06-05	2014-06-06	5,000	—	$0	5,000	SEC↗
SANDELL SCOTT D	10% Owner	J Other	2014-06-05	2014-06-06	500,000	—	$0	2,384,221	SEC↗
KOLLURI KRISHNA KITTU	10% Owner	J Other	2014-06-05	2014-06-06	5,000	—	$0	5,000	SEC↗
KOLLURI KRISHNA KITTU	10% Owner	J Other	2014-06-05	2014-06-06	500,000	—	$0	2,384,221	SEC↗
KOLLURI KRISHNA KITTU	10% Owner	J Other	2014-06-05	2014-06-06	5,000	—	$0	0	SEC↗
KOLLURI KRISHNA KITTU	10% Owner	J Other	2014-06-05	2014-06-06	100	—	$0	100	SEC↗
KOLLURI KRISHNA KITTU	10% Owner	J Other	2014-06-05	2014-06-06	10	—	$0	10	SEC↗
KOLLURI KRISHNA KITTU	10% Owner	J Other	2014-06-05	2014-06-06	10	—	$0	10	SEC↗
KERINS PATRICK J	10% Owner	J Other	2014-06-05	2014-06-06	500,000	—	$0	2,384,221	SEC↗
KERINS PATRICK J	10% Owner	J Other	2014-06-05	2014-06-06	5,000	—	$0	5,000	SEC↗
KERINS PATRICK J	10% Owner	J Other	2014-06-05	2014-06-06	5,000	—	$0	0	SEC↗
KERINS PATRICK J	10% Owner	J Other	2014-06-05	2014-06-06	120	—	$0	120	SEC↗
DRANT RYAN D	10% Owner	J Other	2014-06-05	2014-06-06	5,000	—	$0	5,000	SEC↗
DRANT RYAN D	10% Owner	J Other	2014-06-05	2014-06-06	500,000	—	$0	2,384,221	SEC↗
DRANT RYAN D	10% Owner	J Other	2014-06-05	2014-06-06	5,000	—	$0	0	SEC↗
DRANT RYAN D	10% Owner	J Other	2014-06-05	2014-06-06	266	—	$0	266	SEC↗
DRANT RYAN D	10% Owner	J Other	2014-06-05	2014-06-06	1,134	—	$0	1,134	SEC↗
DRANT RYAN D	10% Owner	J Other	2014-06-05	2014-06-06	30	—	$0	30	SEC↗
BASKETT FOREST	10% Owner	J Other	2014-06-05	2014-06-06	243	—	$0	243	SEC↗
BASKETT FOREST	10% Owner	J Other	2014-06-05	2014-06-06	1,134	—	$0	1,134	SEC↗
BASKETT FOREST	10% Owner	J Other	2014-06-05	2014-06-06	500,000	—	$0	2,384,221	SEC↗
BASKETT FOREST	10% Owner	J Other	2014-06-05	2014-06-06	5,000	—	$0	5,000	SEC↗
BASKETT FOREST	10% Owner	J Other	2014-06-05	2014-06-06	5,000	—	$0	0	SEC↗
BARRETT M JAMES	10% Owner	J Other	2014-06-05	2014-06-06	1,134	—	$0	1,134	SEC↗
BARRETT M JAMES	10% Owner	J Other	2014-06-05	2014-06-06	500,000	—	$0	2,384,221	SEC↗
BARRETT M JAMES	10% Owner	J Other	2014-06-05	2014-06-06	5,000	—	$0	5,000	SEC↗
BARRETT M JAMES	10% Owner	J Other	2014-06-05	2014-06-06	5,000	—	$0	0	SEC↗
BARRETT M JAMES	10% Owner	J Other	2014-06-05	2014-06-06	148	—	$0	148	SEC↗
BARRETT M JAMES	10% Owner	J Other	2014-06-05	2014-06-06	148	—	$0	148	SEC↗
BARRIS PETER J	10% Owner	J Other	2014-06-05	2014-06-06	1,134	—	$0	1,134	SEC↗
BARRIS PETER J	10% Owner	J Other	2014-06-05	2014-06-06	500,000	—	$0	2,384,221	SEC↗
BARRIS PETER J	10% Owner	J Other	2014-06-05	2014-06-06	5,000	—	$0	5,000	SEC↗
BARRIS PETER J	10% Owner	J Other	2014-06-05	2014-06-06	5,000	—	$0	0	SEC↗
BARRIS PETER J	10% Owner	J Other	2014-06-05	2014-06-06	222	—	$0	222	SEC↗
BARRIS PETER J	10% Owner	J Other	2014-06-05	2014-06-06	68	—	$0	68	SEC↗
Sofinnova Management VII, L.L.	10% Owner	S Sale	2014-06-04	2014-06-06	417,747	$27.70	$11.57M	1,939,474	SEC↗
HEALY JAMES	Director	S Sale	2014-06-04	2014-06-06	417,747	$27.70	$11.57M	1,939,474	SEC↗
HEALY JAMES	Director, 10% Owner	A Award deriv	2014-05-27	2014-05-29	4,869	—	$0	4,869	SEC↗
Hansen Bo Jesper	Director	A Award deriv	2014-05-27	2014-05-29	4,869	—	$0	4,869	SEC↗
Salehizadeh Bijan	Director	A Award deriv	2014-05-27	2014-05-29	4,869	—	$0	4,869	SEC↗
WELCH DANIEL G	Director	A Award deriv	2014-05-27	2014-05-29	4,869	—	$0	4,869	SEC↗
Nunn Jason Raleigh	Director	A Award deriv	2014-05-27	2014-05-29	4,869	—	$0	4,869	SEC↗
Zoth Lota S.	Director	A Award deriv	2014-05-27	2014-05-29	4,869	—	$0	4,869	SEC↗
HEALY JAMES	Director, 10% Owner	A Award	2014-05-27	2014-05-29	2,617	—	$0	14,472	SEC↗
Hansen Bo Jesper	Director	A Award	2014-05-27	2014-05-29	2,617	—	$0	2,617	SEC↗
Salehizadeh Bijan	Director	A Award	2014-05-27	2014-05-29	2,617	—	$0	2,617	SEC↗
WELCH DANIEL G	Director	A Award	2014-05-27	2014-05-29	2,617	—	$0	2,617	SEC↗
Nunn Jason Raleigh	Director	A Award	2014-05-27	2014-05-29	2,617	—	$0	2,617	SEC↗
Zoth Lota S.	Director	A Award	2014-05-27	2014-05-29	2,617	—	$0	2,617	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise deriv	2014-04-01	2014-04-02	3,592	—	$0	36,443	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise deriv	2014-04-01	2014-04-02	1,640	—	$0	7,105	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise	2014-04-01	2014-04-02	3,592	$7.31	$26.3K	87,759	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise	2014-04-01	2014-04-02	1,640	$4.08	$6.7K	89,399	SEC↗
Gould Ashley C.	SVP Govt Aff & Chief Legal O	A Award	2014-03-14	2014-03-13	5,700	—	$0	5,700	SEC↗
Dickinson Klara	SVP Reg. Affairs & Complianc	A Award deriv	2014-03-11	2014-03-13	12,000	—	$0	12,000	SEC↗
Farrow Jeffrey S	CFO & Secretary	A Award deriv	2014-03-11	2014-03-13	38,000	—	$0	38,000	SEC↗
Gould Ashley C.	SVP Govt Aff & Chief Legal O	A Award deriv	2014-03-11	2014-03-13	34,000	—	$0	34,000	SEC↗
Holles Natalie C.	SVP, Business Development	A Award deriv	2014-03-11	2014-03-13	29,000	—	$0	29,000	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	A Award deriv	2014-03-11	2014-03-13	50,000	—	$0	50,000	SEC↗
Santel Donald J	CEO & President	A Award deriv	2014-03-11	2014-03-13	111,000	—	$0	111,000	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	A Award deriv	2014-03-11	2014-03-13	32,000	—	$0	32,000	SEC↗
Dickinson Klara	SVP Reg. Affairs & Complianc	A Award	2014-03-11	2014-03-13	2,000	—	$0	2,283	SEC↗
Farrow Jeffrey S	CFO & Secretary	A Award	2014-03-11	2014-03-13	6,250	—	$0	6,250	SEC↗
Holles Natalie C.	SVP, Business Development	A Award	2014-03-11	2014-03-13	5,000	—	$0	5,000	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	A Award	2014-03-11	2014-03-13	10,000	—	$0	24,998	SEC↗
Santel Donald J	CEO & President	A Award	2014-03-11	2014-03-13	18,500	—	$0	18,500	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	A Award	2014-03-11	2014-03-13	5,400	—	$0	84,167	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	M Exercise deriv	2014-03-06	2014-03-10	15,000	—	$0	26,157	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	S Sale	2014-03-06	2014-03-10	5,000	$29.03	$145.2K	15,098	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	S Sale	2014-03-06	2014-03-10	100	$30.05	$3.0K	14,998	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	M Exercise	2014-03-06	2014-03-10	15,000	$1.28	$19.2K	20,098	SEC↗
POWELL MICHAEL	10% Owner	S Sale	2014-03-04	2014-03-05	23,625	$30.02	$709.2K	0	SEC↗
POWELL MICHAEL	10% Owner	J Other	2014-03-03	2014-03-05	23,625	—	$0	23,625	SEC↗
POWELL MICHAEL	10% Owner	J Other	2014-03-03	2014-03-05	590,000	—	$0	2,357,221	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	M Exercise deriv	2014-01-14	2014-01-14	6,100	—	$0	41,157	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	M Exercise	2014-01-14	2014-01-14	6,100	$1.28	$7.8K	6,198	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	S Sale	2014-01-14	2014-01-14	1,100	$24.01	$26.4K	5,098	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	M Exercise deriv	2014-01-10	2014-01-14	8,900	—	$0	47,257	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	M Exercise	2014-01-10	2014-01-14	8,900	$1.28	$11.4K	8,998	SEC↗
Nash Christine A	SVP & Chief Commercial Offic	S Sale	2014-01-10	2014-01-14	8,900	$24.10	$214.5K	98	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise deriv	2014-01-06	2014-01-06	4,033	—	$0	40,035	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise deriv	2014-01-06	2014-01-06	3,825	—	$0	8,745	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise	2014-01-06	2014-01-06	3,825	$4.08	$15.6K	74,734	SEC↗
Scharschmidt Bruce Frederick	SVP & Chief Medical Officer	M Exercise	2014-01-06	2014-01-06	4,033	$7.31	$29.5K	78,767	SEC↗
Bay City Capital Fund V Co-Inv	10% Owner	X Exercise	2013-10-18	2013-10-21	3,740	$26.00	$97.2K	35,820	SEC↗
Bay City Capital Fund V Co-Inv	10% Owner	X Exercise	2013-10-18	2013-10-21	196,260	$26.00	$5.10M	1,879,836	SEC↗
Highland Capital Partners VII-	10% Owner	S Sale	2013-09-20	2013-09-23	83	$25.81	$2.1K	38,616	SEC↗
Highland Capital Partners VII-	10% Owner	S Sale	2013-09-20	2013-09-23	2,643	$25.81	$68.2K	1,232,721	SEC↗
Highland Capital Partners VII-	10% Owner	S Sale	2013-09-20	2013-09-23	641	$25.81	$16.5K	298,707	SEC↗
Highland Capital Partners VII-	10% Owner	S Sale	2013-09-20	2013-09-23	933	$25.81	$24.1K	435,013	SEC↗
Highland Capital Partners VII-	10% Owner	S Sale	2013-09-19	2013-09-23	894	$25.93	$23.2K	1,235,364	SEC↗
Highland Capital Partners VII-	10% Owner	S Sale	2013-09-19	2013-09-23	315	$25.93	$8.2K	435,946	SEC↗
Highland Capital Partners VII-	10% Owner	S Sale	2013-09-19	2013-09-23	28	$25.93	$726	38,699	SEC↗
Highland Capital Partners VII-	10% Owner	S Sale	2013-09-19	2013-09-23	217	$25.93	$5.6K	299,348	SEC↗
Highland Capital Partners VII	10% Owner	S Sale	2013-09-18	2013-09-19	111	$26.03	$2.9K	38,727	SEC↗
Highland Capital Partners VII	10% Owner	S Sale	2013-09-18	2013-09-19	3,547	$26.03	$92.3K	1,236,258	SEC↗
Highland Capital Partners VII	10% Owner	S Sale	2013-09-18	2013-09-19	860	$26.03	$22.4K	299,565	SEC↗
Highland Capital Partners VII	10% Owner	S Sale	2013-09-18	2013-09-19	1,252	$26.03	$32.6K	436,261	SEC↗
Highland Capital Partners VII	10% Owner	S Sale	2013-09-17	2013-09-19	188	$25.99	$4.9K	38,838	SEC↗
Highland Capital Partners VII	10% Owner	S Sale	2013-09-17	2013-09-19	2,121	$25.99	$55.1K	437,513	SEC↗
Highland Capital Partners VII	10% Owner	S Sale	2013-09-17	2013-09-19	6,009	$25.99	$156.2K	1,239,805	SEC↗