Open-mkt buys · 90d
—
0 trades · 0 insiders
Open-mkt sales · 90d
$985.4K
2 trades · 1 insiders
Net · 90d
$-985.4K
Insiders on file
29
Daily buy vs sell · 90 days
■ Open-market buys (P) ■ Open-market sales (S) · daily dollar value by transaction date
Insiders
| Insider | Role | Trades | Bought | Sold | Last trade |
|---|---|---|---|---|---|
| Hata Yujiro S | President and CEO, Director | 53 | $0 | $18.54M | 2026-10-06 |
| Ruiz Briseno Andres | See Remarks | 14 | $0 | $762.2K | 2026-07-07 |
| Hampton Malcolm Garret | Director | 7 | $0 | $0 | 2026-06-16 |
| Morrison Scott W | Director | 8 | $0 | $0 | 2026-06-16 |
| MACKEY CATHERINE J | Director | 5 | $0 | $0 | 2026-06-16 |
| Stein Jeffrey | Director | 9 | $1.65M | $0 | 2026-06-16 |
| ROSEN TERRY J | Director | 8 | $0 | $0 | 2026-06-16 |
| YARNO WENDY L | Director | 8 | $0 | $0 | 2026-06-16 |
| Bleharski Joshua | Chief Financial Officer | 1 | $0 | $0 | 2026-01-30 |
| DORMAN STUART | Chief Commercial Officer | 2 | $0 | $0 | 2026-01-30 |
| WHITE MICHAEL ANTHONY | SVP, Chief Scientific Officer | 10 | $0 | $1.03M | 2026-01-30 |
| Snyder Douglas B. | SVP, General Counsel | 5 | $0 | $0 | 2026-01-30 |
| Beaupre Darrin | Chief Medical Officer | 4 | $0 | $0 | 2026-01-30 |
| Throne Jason | VP, General Counsel | 59 | $0 | $1.62M | 2024-06-27 |
| Kelley Susan L. | Director | 6 | $0 | $0 | 2024-05-31 |
| Stone Paul A. | SVP, General Counsel | 33 | $2.50M | $463.2K | 2023-08-29 |
| SHANNON TIMOTHY M | Director | 10 | $4.00M | $0 | 2023-06-07 |
| Dillon Michael P. | SVP, Chief Scientific Officer | 46 | $0 | $1.50M | 2021-10-04 |
| Lackner Mark | SVP, Head of Biology | 29 | $0 | $204.2K | 2021-02-24 |
| BVF PARTNERS L P/IL | Other | 3 | $0 | $835.4K | 2021-02-02 |
| Schwab Andrew J. | 10% Owner | 3 | $0 | $10.93M | 2020-11-11 |
| BVF I GP LLC | Other | 3 | $33.7K | $0 | 2020-06-30 |
| BVF Partners OS Ltd. | Other | 6 | $1.69M | $0 | 2020-06-22 |
| Hambleton Julie | SVP, Chief Medical Officer | 1 | $0 | $0 | 2020-02-21 |
| DIEKMAN JOHN D | Director | 11 | $2.50M | $0 | 2019-09-24 |
| Hager Jeffrey | SVP, Chief Technology Officer | 6 | $0 | $0 | 2019-07-26 |
| Alexandria Venture Investments, LLC | 10% Owner | 4 | $500.0K | $0 | 2019-05-28 |
| CANAAN X L.P. | 10% Owner | 5 | $4.00M | $0 | 2019-05-28 |
| 5AM Ventures IV, L.P. | 10% Owner | 11 | $7.50M | $0 | 2019-05-28 |
Trade history
| Insider | Role | Code | Trade | Filed | Shares | Price | Value | Owned after | |
|---|---|---|---|---|---|---|---|---|---|
| Hata Yujiro S | President and CEO, Director | M Exercise deriv | 2026-10-06 | 2026-10-08 | 26,338 | — | $0 | 23,116 | SEC↗ |
| Hata Yujiro S | President and CEO, Director | S Sale | 2026-10-06 | 2026-10-08 | 800 | $38.26 | $30.6K | 690,695 | SEC↗ |
| Hata Yujiro S | President and CEO, Director | S Sale | 2026-10-06 | 2026-10-08 | 25,538 | $37.39 | $954.8K | 691,495 | SEC↗ |
| Hata Yujiro S | President and CEO, Director | M Exercise | 2026-10-06 | 2026-10-08 | 26,338 | $4.31 | $113.5K | 717,033 | SEC↗ |
| Ruiz Briseno Andres | Chief Accounting Officer | M Exercise deriv | 2026-07-07 | 2026-07-09 | 9,550 | — | $0 | 19,200 | SEC↗ |
| Ruiz Briseno Andres | Chief Accounting Officer | M Exercise | 2026-07-07 | 2026-07-09 | 9,550 | $12.86 | $122.8K | 36,016 | SEC↗ |
| Ruiz Briseno Andres | Chief Accounting Officer | S Sale | 2026-07-07 | 2026-07-09 | 9,550 | $40.01 | $382.1K | 26,466 | SEC↗ |
| Hampton Malcolm Garret | Director | A Award deriv | 2026-06-16 | 2026-06-18 | 20,000 | — | $0 | 20,000 | SEC↗ |
| MACKEY CATHERINE J | Director | A Award deriv | 2026-06-16 | 2026-06-18 | 20,000 | — | $0 | 20,000 | SEC↗ |
| Morrison Scott W | Director | A Award deriv | 2026-06-16 | 2026-06-18 | 20,000 | — | $0 | 20,000 | SEC↗ |
| ROSEN TERRY J | Director | A Award deriv | 2026-06-16 | 2026-06-18 | 20,000 | — | $0 | 20,000 | SEC↗ |
| Stein Jeffrey | Director | A Award deriv | 2026-06-16 | 2026-06-18 | 20,000 | — | $0 | 20,000 | SEC↗ |
| YARNO WENDY L | Director | A Award deriv | 2026-06-16 | 2026-06-18 | 20,000 | — | $0 | 20,000 | SEC↗ |
| Stein Jeffrey | Director | P Buy | 2026-03-02 | 2026-03-02 | 50,000 | $32.96 | $1.65M | 54,281 | SEC↗ |
| Ruiz Briseno Andres | See Remarks | A Award deriv | 2026-01-30 | 2026-02-02 | 80,000 | — | $0 | 80,000 | SEC↗ |
| Snyder Douglas B. | SVP, General Counsel | A Award deriv | 2026-01-30 | 2026-02-02 | 130,000 | — | $0 | 130,000 | SEC↗ |
| Hata Yujiro S | President and CEO | A Award deriv | 2026-01-30 | 2026-02-02 | 600,000 | — | $0 | 600,000 | SEC↗ |
| DORMAN STUART | Chief Commercial Officer | A Award deriv | 2026-01-30 | 2026-02-02 | 155,000 | — | $0 | 155,000 | SEC↗ |
| Beaupre Darrin | Chief Medical Officer | A Award deriv | 2026-01-30 | 2026-02-02 | 175,000 | — | $0 | 175,000 | SEC↗ |
| WHITE MICHAEL ANTHONY | Chief Scientific Officer | A Award deriv | 2026-01-30 | 2026-02-02 | 190,000 | — | $0 | 190,000 | SEC↗ |
| Bleharski Joshua | Chief Financial Officer | A Award deriv | 2026-01-30 | 2026-02-02 | 170,000 | — | $0 | 170,000 | SEC↗ |
| Ruiz Briseno Andres | See Remarks | A Award | 2025-11-28 | 2026-02-02 | 1,253 | $16.91 | $21.2K | 26,466 | SEC↗ |
| Snyder Douglas B. | SVP, General Counsel | A Award | 2025-11-28 | 2026-02-02 | 1,041 | $16.91 | $17.6K | 2,080 | SEC↗ |
| ROSEN TERRY J | Director | A Award deriv | 2025-06-24 | 2025-06-26 | 20,000 | — | $0 | 20,000 | SEC↗ |
| MACKEY CATHERINE J | Director | A Award deriv | 2025-06-24 | 2025-06-26 | 20,000 | — | $0 | 20,000 | SEC↗ |
| Morrison Scott W | Director | A Award deriv | 2025-06-24 | 2025-06-26 | 20,000 | — | $0 | 20,000 | SEC↗ |
| Hampton Malcolm Garret | Director | A Award deriv | 2025-06-24 | 2025-06-26 | 20,000 | — | $0 | 20,000 | SEC↗ |
| Stein Jeffrey | Director | A Award deriv | 2025-06-24 | 2025-06-26 | 20,000 | — | $0 | 20,000 | SEC↗ |
| YARNO WENDY L | Director | A Award deriv | 2025-06-24 | 2025-06-26 | 20,000 | — | $0 | 20,000 | SEC↗ |
| Snyder Douglas B. | SVP, General Counsel | A Award | 2025-05-30 | 2026-02-02 | 1,039 | $16.91 | $17.6K | 1,039 | SEC↗ |
| Hata Yujiro S | President and CEO | A Award deriv | 2025-02-27 | 2025-02-28 | 600,000 | — | $0 | 600,000 | SEC↗ |
| Snyder Douglas B. | SVP, General Counsel | A Award deriv | 2025-02-27 | 2025-02-28 | 33,000 | — | $0 | 33,000 | SEC↗ |
| WHITE MICHAEL ANTHONY | Chief Scientific Officer | A Award deriv | 2025-02-27 | 2025-02-28 | 185,000 | — | $0 | 185,000 | SEC↗ |
| Ruiz Briseno Andres | See Remarks | A Award deriv | 2025-02-27 | 2025-02-28 | 75,000 | — | $0 | 75,000 | SEC↗ |
| DORMAN STUART | Chief Commercial Officer | A Award deriv | 2025-02-27 | 2025-02-28 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Beaupre Darrin | Chief Medical Officer | A Award deriv | 2025-02-27 | 2025-02-28 | 185,000 | — | $0 | 185,000 | SEC↗ |
| Hata Yujiro S | President and CEO | M Exercise deriv | 2025-02-18 | 2025-02-19 | 12,808 | — | $0 | 182,192 | SEC↗ |
| Hata Yujiro S | President and CEO | M Exercise | 2025-02-18 | 2025-02-19 | 12,808 | $19.52 | $250.0K | 690,695 | SEC↗ |
| Ruiz Briseno Andres | See Remarks | A Award | 2024-11-29 | 2026-02-02 | 682 | $23.26 | $15.9K | 25,213 | SEC↗ |
| Snyder Douglas B. | SVP, General Counsel | A Award deriv | 2024-09-26 | 2024-09-27 | 140,000 | — | $0 | 140,000 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise deriv | 2024-06-27 | 2024-06-27 | 47,060 | — | $0 | 1,360 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise deriv | 2024-06-27 | 2024-06-27 | 6,424 | — | $0 | 41,186 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise | 2024-06-27 | 2024-06-27 | 6,424 | $13.34 | $85.7K | 16,424 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise | 2024-06-27 | 2024-06-27 | 47,060 | $7.01 | $329.9K | 63,484 | SEC↗ |
| MACKEY CATHERINE J | Director | A Award deriv | 2024-05-31 | 2024-05-31 | 16,200 | — | $0 | 16,200 | SEC↗ |
| YARNO WENDY L | Director | A Award deriv | 2024-05-31 | 2024-05-31 | 16,200 | — | $0 | 16,200 | SEC↗ |
| Morrison Scott W | Director | A Award deriv | 2024-05-31 | 2024-05-31 | 16,200 | — | $0 | 16,200 | SEC↗ |
| Stein Jeffrey | Director | A Award deriv | 2024-05-31 | 2024-05-31 | 16,200 | — | $0 | 16,200 | SEC↗ |
| Hampton Malcolm Garret | Director | A Award deriv | 2024-05-31 | 2024-05-31 | 16,200 | — | $0 | 16,200 | SEC↗ |
| Kelley Susan L. | Director | A Award deriv | 2024-05-31 | 2024-05-31 | 16,200 | — | $0 | 16,200 | SEC↗ |
| ROSEN TERRY J | Director | A Award deriv | 2024-05-31 | 2024-05-31 | 16,200 | — | $0 | 16,200 | SEC↗ |
| WHITE MICHAEL ANTHONY | Chief Scientific Officer | M Exercise deriv | 2024-05-29 | 2024-05-31 | 28,500 | — | $0 | 64,000 | SEC↗ |
| WHITE MICHAEL ANTHONY | Chief Scientific Officer | S Sale | 2024-05-29 | 2024-05-31 | 851 | $36.78 | $31.3K | 0 | SEC↗ |
| WHITE MICHAEL ANTHONY | Chief Scientific Officer | M Exercise | 2024-05-29 | 2024-05-31 | 28,500 | $12.86 | $366.5K | 28,500 | SEC↗ |
| WHITE MICHAEL ANTHONY | Chief Scientific Officer | S Sale | 2024-05-29 | 2024-05-31 | 27,649 | $36.23 | $1.00M | 851 | SEC↗ |
| Hata Yujiro S | President and CEO | M Exercise deriv | 2024-05-16 | 2024-05-16 | 34,433 | — | $0 | 49,454 | SEC↗ |
| Hata Yujiro S | President and CEO | S Sale | 2024-05-16 | 2024-05-16 | 30,084 | $41.73 | $1.26M | 682,236 | SEC↗ |
| Hata Yujiro S | President and CEO | M Exercise | 2024-05-16 | 2024-05-16 | 34,433 | $4.31 | $148.4K | 712,320 | SEC↗ |
| Hata Yujiro S | President and CEO | S Sale | 2024-05-16 | 2024-05-16 | 4,349 | $42.37 | $184.3K | 677,887 | SEC↗ |
| Hata Yujiro S | President and CEO | M Exercise deriv | 2024-05-15 | 2024-05-16 | 83,856 | — | $0 | 83,887 | SEC↗ |
| Hata Yujiro S | President and CEO | M Exercise | 2024-05-15 | 2024-05-16 | 83,856 | $4.31 | $361.4K | 761,743 | SEC↗ |
| Hata Yujiro S | President and CEO | S Sale | 2024-05-15 | 2024-05-16 | 503 | $44.12 | $22.2K | 677,887 | SEC↗ |
| Hata Yujiro S | President and CEO | S Sale | 2024-05-15 | 2024-05-16 | 29,761 | $43.48 | $1.29M | 678,390 | SEC↗ |
| Hata Yujiro S | President and CEO | S Sale | 2024-05-15 | 2024-05-16 | 53,592 | $42.57 | $2.28M | 708,151 | SEC↗ |
| Hata Yujiro S | President and CEO | M Exercise deriv | 2024-05-14 | 2024-05-16 | 56,711 | — | $0 | 167,743 | SEC↗ |
| Hata Yujiro S | President and CEO | S Sale | 2024-05-14 | 2024-05-16 | 2,303 | $41.84 | $96.4K | 677,887 | SEC↗ |
| Hata Yujiro S | President and CEO | S Sale | 2024-05-14 | 2024-05-16 | 54,408 | $41.60 | $2.26M | 680,190 | SEC↗ |
| Hata Yujiro S | President and CEO | M Exercise | 2024-05-14 | 2024-05-16 | 56,711 | $4.31 | $244.4K | 734,598 | SEC↗ |
| Throne Jason | Chief Legal Officer | A Award deriv | 2024-03-01 | 2024-03-04 | 125,500 | — | $0 | 125,500 | SEC↗ |
| WHITE MICHAEL ANTHONY | Chief Scientific Officer | A Award deriv | 2024-03-01 | 2024-03-04 | 140,000 | — | $0 | 140,000 | SEC↗ |
| Beaupre Darrin | Chief Medical Officer | A Award deriv | 2024-03-01 | 2024-03-04 | 160,000 | — | $0 | 160,000 | SEC↗ |
| Ruiz Briseno Andres | See Remarks | A Award deriv | 2024-03-01 | 2024-03-04 | 85,000 | — | $0 | 85,000 | SEC↗ |
| Hata Yujiro S | President and CEO | A Award deriv | 2024-03-01 | 2024-03-04 | 480,000 | — | $0 | 480,000 | SEC↗ |
| Hata Yujiro S | President and CEO | M Exercise deriv | 2024-02-09 | 2024-02-12 | 23,557 | — | $0 | 224,454 | SEC↗ |
| Hata Yujiro S | President and CEO | S Sale | 2024-02-09 | 2024-02-12 | 23,557 | $45.54 | $1.07M | 677,887 | SEC↗ |
| Hata Yujiro S | President and CEO | M Exercise | 2024-02-09 | 2024-02-12 | 23,557 | $4.31 | $101.5K | 701,444 | SEC↗ |
| Ruiz Briseno Andres | See Remarks | S Sale | 2024-02-09 | 2024-02-13 | 2,000 | $46.02 | $92.0K | 24,531 | SEC↗ |
| Hata Yujiro S | President and CEO | M Exercise deriv | 2024-02-08 | 2024-02-12 | 75,815 | — | $0 | 248,011 | SEC↗ |
| Hata Yujiro S | President and CEO | S Sale | 2024-02-08 | 2024-02-12 | 75,815 | $45.15 | $3.42M | 677,887 | SEC↗ |
| Hata Yujiro S | President and CEO | M Exercise | 2024-02-08 | 2024-02-12 | 75,815 | $4.31 | $326.8K | 753,702 | SEC↗ |
| Hata Yujiro S | President and CEO | M Exercise deriv | 2024-02-01 | 2024-02-05 | 628 | — | $0 | 323,826 | SEC↗ |
| Hata Yujiro S | President and CEO | S Sale | 2024-02-01 | 2024-02-05 | 624 | $45.00 | $28.1K | 677,891 | SEC↗ |
| Hata Yujiro S | President and CEO | S Sale | 2024-02-01 | 2024-02-05 | 4 | $45.01 | $180 | 677,887 | SEC↗ |
| Hata Yujiro S | President and CEO | M Exercise | 2024-02-01 | 2024-02-05 | 628 | $4.31 | $2.7K | 678,515 | SEC↗ |
| Ruiz Briseno Andres | See Remarks | S Sale | 2024-01-22 | 2024-01-24 | 2,000 | $42.03 | $84.1K | 26,531 | SEC↗ |
| Hata Yujiro S | President and CEO | M Exercise deriv | 2024-01-16 | 2024-01-17 | 62,739 | — | $0 | 324,454 | SEC↗ |
| Hata Yujiro S | President and CEO | S Sale | 2024-01-16 | 2024-01-17 | 62,739 | $40.17 | $2.52M | 677,887 | SEC↗ |
| Hata Yujiro S | President and CEO | M Exercise | 2024-01-16 | 2024-01-17 | 62,739 | $4.31 | $270.4K | 740,626 | SEC↗ |
| Hata Yujiro S | President and CEO | M Exercise deriv | 2024-01-12 | 2024-01-17 | 12,261 | — | $0 | 387,193 | SEC↗ |
| Hata Yujiro S | President and CEO | M Exercise | 2024-01-12 | 2024-01-17 | 12,261 | $4.31 | $52.8K | 690,148 | SEC↗ |
| Hata Yujiro S | President and CEO | S Sale | 2024-01-12 | 2024-01-17 | 12,261 | $40.04 | $490.9K | 677,887 | SEC↗ |
| Ruiz Briseno Andres | See Remarks | S Sale | 2024-01-12 | 2024-01-17 | 2,000 | $38.01 | $76.0K | 28,531 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise deriv | 2023-12-18 | 2023-12-19 | 10,000 | — | $0 | 48,420 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise | 2023-12-18 | 2023-12-19 | 10,000 | $7.01 | $70.1K | 10,000 | SEC↗ |
| Hata Yujiro S | President and CEO | M Exercise deriv | 2023-12-15 | 2023-12-19 | 75,000 | — | $0 | 399,454 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise deriv | 2023-12-15 | 2023-12-19 | 10,000 | — | $0 | 47,610 | SEC↗ |
| Hata Yujiro S | President and CEO | S Sale | 2023-12-15 | 2023-12-19 | 75,000 | $35.03 | $2.63M | 677,887 | SEC↗ |
| Hata Yujiro S | President and CEO | M Exercise | 2023-12-15 | 2023-12-19 | 75,000 | $4.31 | $323.2K | 752,887 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise | 2023-12-15 | 2023-12-19 | 10,000 | $13.34 | $133.4K | 10,000 | SEC↗ |
| Throne Jason | Chief Legal Officer | S Sale | 2023-12-15 | 2023-12-19 | 10,000 | $35.04 | $350.4K | 0 | SEC↗ |
| Ruiz Briseno Andres | See Remarks | S Sale | 2023-12-14 | 2023-12-18 | 1,672 | $34.00 | $56.8K | 30,859 | SEC↗ |
| Ruiz Briseno Andres | See Remarks | S Sale | 2023-12-14 | 2023-12-18 | 328 | $34.01 | $11.2K | 30,531 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise deriv | 2023-11-03 | 2023-11-07 | 5,163 | — | $0 | 48,750 | SEC↗ |
| Throne Jason | Chief Legal Officer | S Sale | 2023-11-03 | 2023-11-07 | 5,163 | $30.09 | $155.4K | 0 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise | 2023-11-03 | 2023-11-07 | 5,163 | $12.86 | $66.4K | 5,163 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise deriv | 2023-09-12 | 2023-09-14 | 1,000 | — | $0 | 53,913 | SEC↗ |
| Throne Jason | Chief Legal Officer | S Sale | 2023-09-12 | 2023-09-14 | 500 | $30.00 | $15.0K | 500 | SEC↗ |
| Throne Jason | Chief Legal Officer | S Sale | 2023-09-12 | 2023-09-14 | 500 | $30.01 | $15.0K | 0 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise | 2023-09-12 | 2023-09-14 | 1,000 | $12.86 | $12.9K | 1,000 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise deriv | 2023-09-05 | 2023-09-06 | 1,737 | — | $0 | 54,913 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise | 2023-09-05 | 2023-09-06 | 1,737 | $12.86 | $22.3K | 1,737 | SEC↗ |
| Throne Jason | Chief Legal Officer | S Sale | 2023-09-05 | 2023-09-06 | 1,737 | $30.03 | $52.2K | 0 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise deriv | 2023-09-01 | 2023-09-06 | 2,100 | — | $0 | 56,650 | SEC↗ |
| Ruiz Briseno Andres | See Remarks | S Sale | 2023-09-01 | 2023-09-06 | 2,000 | $30.01 | $60.0K | 32,531 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise | 2023-09-01 | 2023-09-06 | 2,100 | $12.86 | $27.0K | 2,100 | SEC↗ |
| Throne Jason | Chief Legal Officer | S Sale | 2023-09-01 | 2023-09-06 | 2,100 | $30.03 | $63.1K | 0 | SEC↗ |
| Stone Paul A. | Chief Financial Officer | S Sale | 2023-08-29 | 2023-08-31 | 5,000 | $28.87 | $144.3K | 9,303 | SEC↗ |
| Stone Paul A. | Chief Financial Officer | S Sale | 2023-08-21 | 2023-08-23 | 978 | $26.40 | $25.8K | 14,303 | SEC↗ |
| Stone Paul A. | Chief Financial Officer | S Sale | 2023-08-18 | 2023-08-18 | 3,822 | $26.38 | $100.8K | 15,281 | SEC↗ |
| Stone Paul A. | Chief Financial Officer | S Sale | 2023-08-16 | 2023-08-18 | 100 | $26.40 | $2.6K | 19,103 | SEC↗ |
| Stone Paul A. | Chief Financial Officer | S Sale | 2023-08-16 | 2023-08-18 | 100 | $26.45 | $2.6K | 19,203 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise deriv | 2023-08-09 | 2023-08-11 | 5,000 | — | $0 | 57,610 | SEC↗ |
| Stone Paul A. | Chief Financial Officer | S Sale | 2023-08-09 | 2023-08-11 | 2,500 | $25.05 | $62.6K | 19,303 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise | 2023-08-09 | 2023-08-11 | 5,000 | $13.34 | $66.7K | 5,000 | SEC↗ |
| Throne Jason | Chief Legal Officer | S Sale | 2023-08-09 | 2023-08-11 | 5,000 | $25.09 | $125.5K | 0 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise deriv | 2023-07-10 | 2023-07-12 | 5,000 | — | $0 | 58,750 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise deriv | 2023-07-10 | 2023-07-12 | 4,485 | — | $0 | 58,420 | SEC↗ |
| Throne Jason | Chief Legal Officer | S Sale | 2023-07-10 | 2023-07-12 | 9,485 | $23.00 | $218.2K | 0 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise | 2023-07-10 | 2023-07-12 | 4,485 | $7.01 | $31.4K | 4,485 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise | 2023-07-10 | 2023-07-12 | 5,000 | $12.86 | $64.3K | 9,485 | SEC↗ |
| YARNO WENDY L | Director | A Award deriv | 2023-06-07 | 2023-06-09 | 16,200 | — | $0 | 16,200 | SEC↗ |
| Stein Jeffrey | Director | A Award deriv | 2023-06-07 | 2023-06-09 | 16,200 | — | $0 | 16,200 | SEC↗ |
| ROSEN TERRY J | Director | A Award deriv | 2023-06-07 | 2023-06-09 | 16,200 | — | $0 | 16,200 | SEC↗ |
| Morrison Scott W | Director | A Award deriv | 2023-06-07 | 2023-06-09 | 16,200 | — | $0 | 16,200 | SEC↗ |
| MACKEY CATHERINE J | Director | A Award deriv | 2023-06-07 | 2023-06-09 | 16,200 | — | $0 | 16,200 | SEC↗ |
| Kelley Susan L. | Director | A Award deriv | 2023-06-07 | 2023-06-09 | 16,200 | — | $0 | 16,200 | SEC↗ |
| Hampton Malcolm Garret | Director | A Award deriv | 2023-06-07 | 2023-06-09 | 16,200 | — | $0 | 16,200 | SEC↗ |
| SHANNON TIMOTHY M | Director | A Award deriv | 2023-06-07 | 2023-06-09 | 16,200 | — | $0 | 16,200 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise deriv | 2023-06-01 | 2023-06-02 | 3,553 | — | $0 | 62,905 | SEC↗ |
| Throne Jason | Chief Legal Officer | S Sale | 2023-06-01 | 2023-06-02 | 3,553 | $23.02 | $81.8K | 0 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise | 2023-06-01 | 2023-06-02 | 3,553 | $7.01 | $24.9K | 3,553 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise deriv | 2023-05-31 | 2023-06-02 | 432 | — | $0 | 66,458 | SEC↗ |
| Throne Jason | Chief Legal Officer | S Sale | 2023-05-31 | 2023-06-02 | 432 | $23.00 | $9.9K | 0 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise | 2023-05-31 | 2023-06-02 | 432 | $7.01 | $3.0K | 432 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise deriv | 2023-05-22 | 2023-05-24 | 500 | — | $0 | 66,890 | SEC↗ |
| Throne Jason | Chief Legal Officer | M Exercise | 2023-05-22 | 2023-05-24 | 500 | $7.01 | $3.5K | 500 | SEC↗ |
| Throne Jason | Chief Legal Officer | S Sale | 2023-05-22 | 2023-05-24 | 500 | $23.00 | $11.5K | 0 | SEC↗ |
| Stone Paul A. | Chief Financial Officer | M Exercise deriv | 2023-04-13 | 2023-04-14 | 8,000 | — | $0 | 129,832 | SEC↗ |
| Stone Paul A. | Chief Financial Officer | M Exercise | 2023-04-13 | 2023-04-14 | 8,000 | $4.62 | $37.0K | 21,803 | SEC↗ |
| Hata Yujiro S | President and CEO | M Exercise deriv | 2023-04-12 | 2023-04-13 | 11,601 | — | $0 | 474,454 | SEC↗ |
| Hata Yujiro S | President and CEO | M Exercise | 2023-04-12 | 2023-04-13 | 11,601 | $4.31 | $50.0K | 677,887 | SEC↗ |
| Hata Yujiro S | President and CEO | A Award deriv | 2023-02-24 | 2023-02-28 | 400,000 | — | $0 | 400,000 | SEC↗ |
| Throne Jason | Chief Legal Officer | A Award deriv | 2023-02-24 | 2023-02-28 | 100,000 | — | $0 | 100,000 | SEC↗ |
| Stone Paul A. | Chief Financial Officer | A Award deriv | 2023-02-24 | 2023-02-28 | 140,000 | — | $0 | 140,000 | SEC↗ |
| Beaupre Darrin | Chief Medical Officer | A Award deriv | 2023-02-24 | 2023-02-28 | 90,000 | — | $0 | 90,000 | SEC↗ |
| WHITE MICHAEL ANTHONY | Chief Scientific Officer | A Award deriv | 2023-02-24 | 2023-02-28 | 165,000 | — | $0 | 165,000 | SEC↗ |
| Hampton Malcolm Garret | Director | A Award deriv | 2022-06-09 | 2022-06-10 | 11,000 | — | $0 | 11,000 | SEC↗ |
| Stein Jeffrey | Director | A Award deriv | 2022-06-09 | 2022-06-10 | 11,000 | — | $0 | 11,000 | SEC↗ |
| Morrison Scott W | Director | A Award deriv | 2022-06-09 | 2022-06-10 | 11,000 | — | $0 | 11,000 | SEC↗ |
| Kelley Susan L. | Director | A Award deriv | 2022-06-09 | 2022-06-10 | 11,000 | — | $0 | 11,000 | SEC↗ |
| Kelley Susan L. | Director | A Award deriv | 2022-06-09 | 2022-06-10 | 11,000 | — | $0 | 11,000 | SEC↗ |
| ROSEN TERRY J | Director | A Award deriv | 2022-06-09 | 2022-06-10 | 11,000 | — | $0 | 11,000 | SEC↗ |
| SHANNON TIMOTHY M | Director | A Award deriv | 2022-06-09 | 2022-06-10 | 11,000 | — | $0 | 11,000 | SEC↗ |
| YARNO WENDY L | Director | A Award deriv | 2022-06-09 | 2022-06-10 | 11,000 | — | $0 | 11,000 | SEC↗ |
| MACKEY CATHERINE J | Director | A Award deriv | 2022-04-05 | 2022-04-06 | 22,000 | — | $0 | 22,000 | SEC↗ |
| Throne Jason | SVP, General Counsel | A Award deriv | 2022-03-01 | 2022-03-02 | 63,750 | — | $0 | 63,750 | SEC↗ |
| Hata Yujiro S | President and CEO | A Award deriv | 2022-03-01 | 2022-03-02 | 260,000 | — | $0 | 260,000 | SEC↗ |
| WHITE MICHAEL ANTHONY | SVP, Chief Scientific Office | A Award deriv | 2022-03-01 | 2022-03-02 | 92,500 | — | $0 | 92,500 | SEC↗ |
| Stone Paul A. | SVP, Chief Financial Officer | A Award deriv | 2022-03-01 | 2022-03-02 | 92,500 | — | $0 | 92,500 | SEC↗ |
| WHITE MICHAEL ANTHONY | SVP, Chief Scientific Office | A Award deriv | 2021-10-25 | 2021-10-27 | 200,000 | — | $0 | 200,000 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise deriv | 2021-10-04 | 2021-10-07 | 1,500 | — | $0 | 23,437 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise | 2021-10-04 | 2021-10-07 | 1,500 | $11.08 | $16.6K | 80,289 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | S Sale | 2021-10-04 | 2021-10-07 | 1,000 | $26.62 | $26.6K | 78,789 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | S Sale | 2021-10-04 | 2021-10-07 | 500 | $25.85 | $12.9K | 79,789 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise deriv | 2021-09-08 | 2021-09-09 | 4,313 | — | $0 | 24,937 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise deriv | 2021-09-08 | 2021-09-09 | 7,071 | — | $0 | 59,048 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise | 2021-09-08 | 2021-09-09 | 7,071 | $4.31 | $30.5K | 85,860 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | S Sale | 2021-09-08 | 2021-09-09 | 11,184 | $27.41 | $306.6K | 78,989 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise | 2021-09-08 | 2021-09-09 | 4,313 | $11.08 | $47.8K | 90,173 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | S Sale | 2021-09-08 | 2021-09-09 | 200 | $27.67 | $5.5K | 78,789 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise deriv | 2021-09-07 | 2021-09-09 | 116 | — | $0 | 66,119 | SEC↗ |
| Stone Paul A. | SVP, Chief Financial Officer | S Sale | 2021-09-07 | 2021-09-09 | 2,500 | $27.42 | $68.5K | 12,944 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | S Sale | 2021-09-07 | 2021-09-09 | 116 | $27.46 | $3.2K | 78,789 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise | 2021-09-07 | 2021-09-09 | 116 | $4.31 | $500 | 78,905 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | S Sale | 2021-09-02 | 2021-09-07 | 10,000 | $25.09 | $250.9K | 78,789 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise deriv | 2021-08-09 | 2021-08-11 | 1,500 | — | $0 | 66,235 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | S Sale | 2021-08-09 | 2021-08-11 | 11,100 | $22.96 | $254.9K | 89,189 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | S Sale | 2021-08-09 | 2021-08-11 | 400 | $23.52 | $9.4K | 88,789 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise | 2021-08-09 | 2021-08-11 | 1,500 | $4.31 | $6.5K | 100,289 | SEC↗ |
| Throne Jason | SVP, General Counsel | M Exercise deriv | 2021-07-27 | 2021-07-29 | 10,000 | — | $0 | 62,610 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise deriv | 2021-07-27 | 2021-07-29 | 5,000 | — | $0 | 39,500 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise deriv | 2021-07-27 | 2021-07-29 | 5,000 | — | $0 | 67,735 | SEC↗ |
| Throne Jason | SVP, General Counsel | S Sale | 2021-07-27 | 2021-07-29 | 10,000 | $25.17 | $251.7K | 0 | SEC↗ |
| Throne Jason | SVP, General Counsel | M Exercise | 2021-07-27 | 2021-07-29 | 10,000 | $13.34 | $133.4K | 10,000 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | S Sale | 2021-07-27 | 2021-07-29 | 10,000 | $25.15 | $251.5K | 98,789 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise | 2021-07-27 | 2021-07-29 | 5,000 | $4.31 | $21.5K | 108,789 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise | 2021-07-27 | 2021-07-29 | 5,000 | $6.92 | $34.6K | 103,789 | SEC↗ |
| Throne Jason | SVP, General Counsel | M Exercise deriv | 2021-07-06 | 2021-07-08 | 7,610 | — | $0 | 67,390 | SEC↗ |
| Throne Jason | SVP, General Counsel | M Exercise deriv | 2021-07-06 | 2021-07-08 | 2,390 | — | $0 | 72,610 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise deriv | 2021-07-06 | 2021-07-08 | 1,500 | — | $0 | 44,500 | SEC↗ |
| Throne Jason | SVP, General Counsel | S Sale | 2021-07-06 | 2021-07-08 | 6,468 | $22.16 | $143.3K | 3,532 | SEC↗ |
| Throne Jason | SVP, General Counsel | S Sale | 2021-07-06 | 2021-07-08 | 2,031 | $22.16 | $45.0K | 359 | SEC↗ |
| Throne Jason | SVP, General Counsel | S Sale | 2021-07-06 | 2021-07-08 | 1,142 | $22.68 | $25.9K | 2,390 | SEC↗ |
| Throne Jason | SVP, General Counsel | S Sale | 2021-07-06 | 2021-07-08 | 359 | $22.68 | $8.1K | 0 | SEC↗ |
| Throne Jason | SVP, General Counsel | M Exercise | 2021-07-06 | 2021-07-08 | 2,390 | $13.34 | $31.9K | 10,000 | SEC↗ |
| Throne Jason | SVP, General Counsel | M Exercise | 2021-07-06 | 2021-07-08 | 7,610 | $7.01 | $53.3K | 7,610 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | S Sale | 2021-07-06 | 2021-07-08 | 1,400 | $22.20 | $31.1K | 98,889 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise | 2021-07-06 | 2021-07-08 | 1,500 | $6.92 | $10.4K | 100,289 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | S Sale | 2021-07-06 | 2021-07-08 | 100 | $22.76 | $2.3K | 98,789 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise deriv | 2021-06-17 | 2021-06-17 | 3,893 | — | $0 | 46,000 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise | 2021-06-17 | 2021-06-17 | 3,893 | $6.92 | $26.9K | 102,682 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | S Sale | 2021-06-17 | 2021-06-17 | 3,893 | $22.49 | $87.6K | 98,789 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise deriv | 2021-06-16 | 2021-06-17 | 1,107 | — | $0 | 49,893 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | S Sale | 2021-06-16 | 2021-06-17 | 1,107 | $22.47 | $24.9K | 98,789 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise | 2021-06-16 | 2021-06-17 | 1,107 | $6.92 | $7.7K | 99,896 | SEC↗ |
| Hampton Malcolm Garret | Director | A Award deriv | 2021-06-10 | 2021-06-16 | 11,000 | — | $0 | 11,000 | SEC↗ |
| Morrison Scott W | Director | A Award deriv | 2021-06-10 | 2021-06-16 | 11,000 | — | $0 | 11,000 | SEC↗ |
| ROSEN TERRY J | Director | A Award deriv | 2021-06-10 | 2021-06-16 | 11,000 | — | $0 | 11,000 | SEC↗ |
| Stein Jeffrey | Director | A Award deriv | 2021-06-10 | 2021-06-16 | 11,000 | — | $0 | 11,000 | SEC↗ |
| YARNO WENDY L | Director | A Award deriv | 2021-06-10 | 2021-06-16 | 11,000 | — | $0 | 11,000 | SEC↗ |
| SHANNON TIMOTHY M | Director | A Award deriv | 2021-06-10 | 2021-06-16 | 11,000 | — | $0 | 11,000 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise deriv | 2021-06-07 | 2021-06-09 | 1,500 | — | $0 | 51,000 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise | 2021-06-07 | 2021-06-09 | 1,500 | $6.92 | $10.4K | 100,289 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | S Sale | 2021-06-07 | 2021-06-09 | 1,500 | $20.22 | $30.3K | 98,789 | SEC↗ |
| Stone Paul A. | SVP, Chief Financial Officer | A Award | 2021-05-28 | 2022-04-14 | 859 | $11.36 | $9.8K | 13,803 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise deriv | 2021-05-11 | 2021-05-13 | 5,000 | — | $0 | 52,500 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise | 2021-05-11 | 2021-05-13 | 5,000 | $6.92 | $34.6K | 103,789 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | S Sale | 2021-05-11 | 2021-05-13 | 5,000 | $20.22 | $101.1K | 98,789 | SEC↗ |
| Stone Paul A. | SVP, Chief Financial Officer | A Award deriv | 2021-02-24 | 2021-02-26 | 80,000 | — | $0 | 80,000 | SEC↗ |
| Hata Yujiro S | President and CEO | A Award deriv | 2021-02-24 | 2021-02-26 | 195,000 | — | $0 | 195,000 | SEC↗ |
| Throne Jason | SVP, General Counsel | A Award deriv | 2021-02-24 | 2021-02-26 | 52,500 | — | $0 | 52,500 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | A Award deriv | 2021-02-24 | 2021-02-26 | 45,000 | — | $0 | 45,000 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | A Award deriv | 2021-02-24 | 2021-02-26 | 80,000 | — | $0 | 80,000 | SEC↗ |
| Kelley Susan L. | Director | A Award deriv | 2021-02-12 | 2021-02-17 | 22,000 | — | $0 | 22,000 | SEC↗ |
| Kelley Susan L. | Director | A Award deriv | 2021-02-12 | 2021-02-17 | 22,000 | — | $0 | 22,000 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | M Exercise deriv | 2021-02-10 | 2021-02-10 | 596 | — | $0 | 33,014 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | S Sale | 2021-02-10 | 2021-02-10 | 596 | $21.00 | $12.5K | 0 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | M Exercise | 2021-02-10 | 2021-02-10 | 596 | $6.98 | $4.2K | 596 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | M Exercise deriv | 2021-02-09 | 2021-02-10 | 1,104 | — | $0 | 33,610 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise deriv | 2021-02-09 | 2021-02-10 | 5,000 | — | $0 | 57,500 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | M Exercise | 2021-02-09 | 2021-02-10 | 1,104 | $6.98 | $7.7K | 1,104 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | S Sale | 2021-02-09 | 2021-02-10 | 1,104 | $21.05 | $23.2K | 0 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | S Sale | 2021-02-09 | 2021-02-10 | 5,000 | $20.74 | $103.7K | 98,789 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise | 2021-02-09 | 2021-02-10 | 5,000 | $6.92 | $34.6K | 103,789 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | M Exercise deriv | 2021-02-08 | 2021-02-10 | 300 | — | $0 | 34,714 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | M Exercise | 2021-02-08 | 2021-02-10 | 300 | $6.98 | $2.1K | 300 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | S Sale | 2021-02-08 | 2021-02-10 | 100 | $21.02 | $2.1K | 200 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | S Sale | 2021-02-08 | 2021-02-10 | 200 | $21.00 | $4.2K | 0 | SEC↗ |
| BVF PARTNERS L P/IL | Other | S Sale | 2021-02-02 | 2021-02-04 | 16,850 | $18.00 | $303.3K | 1,188,131 | SEC↗ |
| BVF PARTNERS L P/IL | Other | S Sale | 2021-02-02 | 2021-02-04 | 25,234 | $18.00 | $454.2K | 1,642,186 | SEC↗ |
| BVF PARTNERS L P/IL | Other | S Sale | 2021-02-02 | 2021-02-04 | 4,325 | $18.00 | $77.8K | 233,150 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | M Exercise deriv | 2021-01-26 | 2021-01-28 | 377 | — | $0 | 61,760 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | M Exercise deriv | 2021-01-26 | 2021-01-28 | 1,123 | — | $0 | 35,014 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | M Exercise | 2021-01-26 | 2021-01-28 | 1,123 | $6.98 | $7.8K | 2,501 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | S Sale | 2021-01-26 | 2021-01-28 | 1,701 | $18.30 | $31.1K | 800 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | S Sale | 2021-01-26 | 2021-01-28 | 800 | $18.79 | $15.0K | 0 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | M Exercise | 2021-01-26 | 2021-01-28 | 377 | $4.62 | $1.7K | 1,378 | SEC↗ |
| Hata Yujiro S | President and CEO | M Exercise deriv | 2020-12-22 | 2020-12-23 | 8,000 | — | $0 | 486,055 | SEC↗ |
| Hata Yujiro S | President and CEO | M Exercise | 2020-12-22 | 2020-12-23 | 8,000 | $4.31 | $34.5K | 666,286 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise deriv | 2020-12-18 | 2020-12-22 | 7,750 | — | $0 | 72,735 | SEC↗ |
| Dillon Michael P. | SVP, Chief Scientific Office | M Exercise | 2020-12-18 | 2020-12-22 | 7,750 | $4.31 | $33.4K | 98,789 | SEC↗ |
| Stone Paul A. | SVP, Chief Financial Officer | J Other | 2020-12-11 | 2020-12-15 | 444 | — | $0 | 15,444 | SEC↗ |
| Throne Jason | SVP, General Counsel | S Sale | 2020-12-04 | 2020-12-08 | 400 | $14.66 | $5.9K | 1,579 | SEC↗ |
| Throne Jason | SVP, General Counsel | S Sale | 2020-12-04 | 2020-12-08 | 1,579 | $15.55 | $24.6K | 0 | SEC↗ |
| Schwab Andrew J. | 10% Owner | S Sale | 2020-11-11 | 2020-11-13 | 657,117 | $13.66 | $8.98M | 2,187,428 | SEC↗ |
| Schwab Andrew J. | 10% Owner | S Sale | 2020-11-11 | 2020-11-13 | 115,504 | $13.66 | $1.58M | 384,496 | SEC↗ |
| Schwab Andrew J. | 10% Owner | S Sale | 2020-11-11 | 2020-11-13 | 27,379 | $13.66 | $374.0K | 91,142 | SEC↗ |
| Throne Jason | SVP, General Counsel | A Award deriv | 2020-07-01 | 2020-07-02 | 75,000 | — | $0 | 75,000 | SEC↗ |
| BVF I GP LLC | Other | P Buy | 2020-06-30 | 2020-07-02 | 81 | $13.32 | $1.1K | 237,475 | SEC↗ |
| BVF I GP LLC | Other | P Buy | 2020-06-30 | 2020-07-02 | 929 | $13.32 | $12.4K | 1,204,981 | SEC↗ |
| BVF I GP LLC | Other | P Buy | 2020-06-30 | 2020-07-02 | 1,521 | $13.32 | $20.3K | 1,667,420 | SEC↗ |
| Hampton Malcolm Garret | Director | A Award deriv | 2020-06-26 | 2020-06-30 | 22,000 | — | $0 | 22,000 | SEC↗ |
| BVF Partners OS Ltd. | Other | P Buy | 2020-06-22 | 2020-06-22 | 10,524 | $13.93 | $146.6K | 1,665,899 | SEC↗ |
| BVF Partners OS Ltd. | Other | P Buy | 2020-06-22 | 2020-06-22 | 1,354 | $13.93 | $18.9K | 237,394 | SEC↗ |
| BVF Partners OS Ltd. | Other | P Buy | 2020-06-22 | 2020-06-22 | 7,854 | $13.93 | $109.4K | 1,204,052 | SEC↗ |
| BVF Partners OS Ltd. | Other | P Buy | 2020-06-19 | 2020-06-22 | 52,443 | $14.39 | $754.7K | 1,655,375 | SEC↗ |
| BVF Partners OS Ltd. | Other | P Buy | 2020-06-19 | 2020-06-22 | 39,052 | $14.39 | $562.0K | 1,196,198 | SEC↗ |
| BVF Partners OS Ltd. | Other | P Buy | 2020-06-19 | 2020-06-22 | 6,769 | $14.39 | $97.4K | 236,040 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | M Exercise deriv | 2020-06-17 | 2020-06-18 | 373 | — | $0 | 62,137 | SEC↗ |
| Stone Paul A. | Chief Financial Officer | M Exercise deriv | 2020-06-17 | 2020-06-19 | 3,100 | — | $0 | 137,832 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | S Sale | 2020-06-17 | 2020-06-18 | 373 | $19.91 | $7.4K | 0 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | M Exercise | 2020-06-17 | 2020-06-18 | 373 | $4.62 | $1.7K | 373 | SEC↗ |
| Stone Paul A. | Chief Financial Officer | S Sale | 2020-06-17 | 2020-06-19 | 600 | $19.95 | $12.0K | 15,000 | SEC↗ |
| Stone Paul A. | Chief Financial Officer | S Sale | 2020-06-17 | 2020-06-19 | 2,500 | $17.50 | $43.8K | 15,600 | SEC↗ |
| Stone Paul A. | Chief Financial Officer | M Exercise | 2020-06-17 | 2020-06-19 | 3,100 | $4.62 | $14.3K | 18,100 | SEC↗ |
| YARNO WENDY L | Director | A Award deriv | 2020-06-16 | 2020-06-18 | 11,000 | — | $0 | 11,000 | SEC↗ |
| Stein Jeffrey | Director | A Award deriv | 2020-06-16 | 2020-06-18 | 11,000 | — | $0 | 11,000 | SEC↗ |
| SHANNON TIMOTHY M | Director | A Award deriv | 2020-06-16 | 2020-06-18 | 11,000 | — | $0 | 11,000 | SEC↗ |
| ROSEN TERRY J | Director | A Award deriv | 2020-06-16 | 2020-06-18 | 11,000 | — | $0 | 11,000 | SEC↗ |
| Morrison Scott W | Director | A Award deriv | 2020-06-16 | 2020-06-18 | 11,000 | — | $0 | 11,000 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | M Exercise deriv | 2020-06-16 | 2020-06-18 | 3,887 | — | $0 | 62,510 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | M Exercise deriv | 2020-06-16 | 2020-06-18 | 2,863 | — | $0 | 36,137 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | M Exercise | 2020-06-16 | 2020-06-18 | 3,887 | $4.62 | $18.0K | 3,887 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | S Sale | 2020-06-16 | 2020-06-18 | 6,750 | $14.93 | $100.8K | 0 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | M Exercise | 2020-06-16 | 2020-06-18 | 2,863 | $6.98 | $20.0K | 6,750 | SEC↗ |
| Throne Jason | VP, General Counsel | S Sale | 2020-06-04 | 2020-06-08 | 2,205 | $8.66 | $19.1K | 0 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | S Sale | 2020-06-02 | 2020-06-04 | 333 | $9.73 | $3.2K | 104 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | S Sale | 2020-06-02 | 2020-06-04 | 408 | $8.55 | $3.5K | 437 | SEC↗ |
| Lackner Mark | SVP, Head of Biology | S Sale | 2020-06-02 | 2020-06-04 | 104 | $10.11 | $1.1K | 0 | SEC↗ |
| Hata Yujiro S | President and CEO | M Exercise deriv | 2020-04-15 | 2020-04-16 | 47,564 | — | $0 | 494,055 | SEC↗ |