Open-mkt buys · 90d
—
0 trades · 0 insiders
Open-mkt sales · 90d
—
0 trades · 0 insiders
Net · 90d
$0
Insiders on file
24
Daily buy vs sell · 90 days
No data yet.
Insiders
| Insider | Role | Trades | Bought | Sold | Last trade |
|---|---|---|---|---|---|
| Cohen Amos | Chief Financial Officer | 2 | $0 | $0 | 2026-06-09 |
| Macdonald Alistair | Chief Operating Officer | 69 | $0 | $14.94M | 2017-09-18 |
| Gaenzle Christopher L | CAO, GC & Sec | 96 | $0 | $7.85M | 2017-09-18 |
| Rush Gregory S | Executive VP and CFO | 89 | $0 | $22.90M | 2017-09-18 |
| Bell Michael Adam | Exec Chair & Pres, Comm Div | 2 | $0 | $0 | 2017-08-10 |
| Gibertini Michael | President Clinical Development | 52 | $0 | $13.01M | 2017-08-01 |
| Thomas H. Lee Parallel (Cayman) Fund VII, L.P. | 10% Owner | 2 | $0 | $0 | 2017-08-01 |
| THL Coinvestment Partners, L.P. | 10% Owner | 2 | $0 | $0 | 2017-08-01 |
| Paques Eric | Director | 2 | $0 | $0 | 2017-05-23 |
| Monaghan Matthew E. | Director | 2 | $0 | $0 | 2017-05-23 |
| Norton David Y | Director | 6 | $0 | $0 | 2017-05-23 |
| Meyers Kenneth F | Director | 2 | $0 | $0 | 2017-05-23 |
| Harty Linda S | Director | 2 | $0 | $0 | 2017-05-23 |
| Kender Richard N | Director | 6 | $0 | $0 | 2017-05-23 |
| Burgstahler David F | Director, 10% Owner | 5 | $43.2K | $0 | 2017-05-23 |
| Breckon Robert W | Director | 38 | $0 | $1.86M | 2017-05-23 |
| KLITGAARD WILLIAM E | Director | 2 | $0 | $0 | 2017-05-23 |
| Macdonald D. Jamie | Chief Executive Officer | 34 | $0 | $15.11M | 2016-09-27 |
| Harwood Charles C Jr | Director | 4 | $0 | $0 | 2016-08-24 |
| 1829356 Ontario Ltd | Director, 10% Owner | 8 | $0 | $665.04M | 2016-08-04 |
| INC Research Mezzanine Co-Invest, LLC | 10% Owner | 4 | $0 | $480.60M | 2016-08-04 |
| Ogle James T. | Director | 26 | $0 | $9.31M | 2016-05-24 |
| ACP INC Research Co-Invest, LLC | 10% Owner | 3 | $0 | $391.32M | 2016-05-06 |
| ONTARIO TEACHERS PENSION PLAN BOARD | Director, 10% Owner | 7 | $0 | $169.73M | 2015-08-17 |
Trade history
| Insider | Role | Code | Trade | Filed | Shares | Price | Value | Owned after | |
|---|---|---|---|---|---|---|---|---|---|
| Cohen Amos | Chief Financial Officer | A Award deriv | 2026-06-09 | 2026-08-24 | 590,000 | — | $0 | 590,000 | SEC↗ |
| Cohen Amos | Chief Financial Officer | A Award deriv | 2026-06-09 | 2026-08-24 | 590,000 | — | $0 | 590,000 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | S Sale | 2017-09-18 | 2017-09-19 | 2,348 | $54.60 | $128.2K | 99,453 | SEC↗ |
| Rush Gregory S | Chief Financial Officer | S Sale | 2017-09-18 | 2017-09-19 | 9,703 | $54.48 | $528.6K | 78,593 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | S Sale | 2017-09-18 | 2017-09-19 | 4,682 | $54.56 | $255.4K | 55,897 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | F Tax w/h | 2017-09-15 | 2017-09-19 | 4,245 | $54.85 | $232.8K | 60,579 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise deriv | 2017-09-01 | 2017-09-05 | 23,668 | — | $0 | 0 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise deriv | 2017-09-01 | 2017-09-05 | 4,733 | — | $0 | 0 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise deriv | 2017-09-01 | 2017-09-05 | 14,200 | — | $0 | 0 | SEC↗ |
| Rush Gregory S | Chief Financial Officer | M Exercise deriv | 2017-09-01 | 2017-09-05 | 71,005 | — | $0 | 0 | SEC↗ |
| Rush Gregory S | Chief Financial Officer | M Exercise deriv | 2017-09-01 | 2017-09-05 | 23,668 | — | $0 | 0 | SEC↗ |
| Rush Gregory S | Chief Financial Officer | M Exercise deriv | 2017-09-01 | 2017-09-05 | 4,066 | — | $0 | 8,132 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise | 2017-09-01 | 2017-09-05 | 23,668 | $16.06 | $380.1K | 88,492 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | S Sale | 2017-09-01 | 2017-09-05 | 4,733 | $58.67 | $277.7K | 64,824 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | S Sale | 2017-09-01 | 2017-09-05 | 9,467 | $58.47 | $553.5K | 69,557 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise | 2017-09-01 | 2017-09-05 | 14,200 | $10.06 | $142.9K | 79,024 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | S Sale | 2017-09-01 | 2017-09-05 | 11,834 | $58.46 | $691.8K | 64,824 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise | 2017-09-01 | 2017-09-05 | 4,733 | $10.57 | $50.0K | 69,557 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | S Sale | 2017-09-01 | 2017-09-05 | 10,198 | $59.10 | $602.7K | 78,294 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | S Sale | 2017-09-01 | 2017-09-05 | 1,636 | $59.60 | $97.5K | 76,658 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | S Sale | 2017-09-01 | 2017-09-05 | 4,733 | $58.35 | $276.2K | 64,824 | SEC↗ |
| Rush Gregory S | Chief Financial Officer | M Exercise | 2017-09-01 | 2017-09-05 | 71,005 | $10.06 | $714.3K | 149,301 | SEC↗ |
| Rush Gregory S | Chief Financial Officer | S Sale | 2017-09-01 | 2017-09-05 | 19,300 | $58.60 | $1.13M | 130,001 | SEC↗ |
| Rush Gregory S | Chief Financial Officer | S Sale | 2017-09-01 | 2017-09-05 | 16,202 | $59.54 | $964.7K | 113,799 | SEC↗ |
| Rush Gregory S | Chief Financial Officer | S Sale | 2017-09-01 | 2017-09-05 | 35,503 | $59.21 | $2.10M | 78,296 | SEC↗ |
| Rush Gregory S | Chief Financial Officer | M Exercise | 2017-09-01 | 2017-09-05 | 23,668 | $16.06 | $380.1K | 101,964 | SEC↗ |
| Rush Gregory S | Chief Financial Officer | S Sale | 2017-09-01 | 2017-09-05 | 11,834 | $58.45 | $691.7K | 88,296 | SEC↗ |
| Rush Gregory S | Chief Financial Officer | M Exercise | 2017-09-01 | 2017-09-05 | 4,066 | $40.12 | $163.1K | 92,362 | SEC↗ |
| Rush Gregory S | Chief Financial Officer | S Sale | 2017-09-01 | 2017-09-05 | 4,066 | $58.39 | $237.4K | 88,296 | SEC↗ |
| Rush Gregory S | Chief Financial Officer | S Sale | 2017-09-01 | 2017-09-05 | 1,834 | $58.68 | $107.6K | 100,130 | SEC↗ |
| Rush Gregory S | Chief Financial Officer | M Exercise deriv | 2017-08-30 | 2017-09-01 | 5,917 | — | $0 | 23,668 | SEC↗ |
| Rush Gregory S | Chief Financial Officer | M Exercise deriv | 2017-08-30 | 2017-09-01 | 35,503 | — | $0 | 71,005 | SEC↗ |
| Rush Gregory S | Chief Financial Officer | M Exercise deriv | 2017-08-30 | 2017-09-05 | 35,503 | — | $0 | 71,005 | SEC↗ |
| Rush Gregory S | Chief Financial Officer | M Exercise deriv | 2017-08-30 | 2017-09-05 | 5,917 | — | $0 | 23,668 | SEC↗ |
| Rush Gregory S | Chief Financial Officer | S Sale | 2017-08-30 | 2017-09-01 | 35,503 | $58.27 | $2.07M | 7,290 | SEC↗ |
| Rush Gregory S | Chief Financial Officer | S Sale | 2017-08-30 | 2017-09-01 | 5,917 | $58.22 | $344.5K | 7,290 | SEC↗ |
| Rush Gregory S | Chief Financial Officer | M Exercise | 2017-08-30 | 2017-09-01 | 5,917 | $16.06 | $95.0K | 13,207 | SEC↗ |
| Rush Gregory S | Chief Financial Officer | M Exercise | 2017-08-30 | 2017-09-01 | 35,503 | $10.06 | $357.2K | 42,793 | SEC↗ |
| Rush Gregory S | Chief Financial Officer | S Sale | 2017-08-30 | 2017-09-05 | 35,503 | $58.27 | $2.07M | 78,296 | SEC↗ |
| Rush Gregory S | Chief Financial Officer | M Exercise | 2017-08-30 | 2017-09-05 | 5,917 | $16.06 | $95.0K | 84,213 | SEC↗ |
| Rush Gregory S | Chief Financial Officer | M Exercise | 2017-08-30 | 2017-09-05 | 35,503 | $10.06 | $357.2K | 113,799 | SEC↗ |
| Rush Gregory S | Chief Financial Officer | S Sale | 2017-08-30 | 2017-09-05 | 5,917 | $58.22 | $344.5K | 78,296 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | M Exercise deriv | 2017-08-17 | 2017-08-21 | 8,828 | — | $0 | 8,828 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | S Sale | 2017-08-17 | 2017-08-21 | 8,828 | $55.65 | $491.3K | 101,801 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | M Exercise | 2017-08-17 | 2017-08-21 | 8,828 | $10.57 | $93.3K | 110,629 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | A Award deriv | 2017-08-10 | 2017-08-14 | 36,429 | — | $0 | 36,429 | SEC↗ |
| Bell Michael Adam | Exec Chair & Pres, Comm Div | A Award deriv | 2017-08-10 | 2017-08-14 | 29,143 | — | $0 | 29,143 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | A Award deriv | 2017-08-10 | 2017-08-14 | 11,803 | — | $0 | 11,803 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | A Award deriv | 2017-08-10 | 2017-08-14 | 11,475 | — | $0 | 11,475 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | M Exercise deriv | 2017-08-01 | 2017-08-02 | 18,000 | — | $0 | 0 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | M Exercise deriv | 2017-08-01 | 2017-08-02 | 17,291 | — | $0 | 0 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise deriv | 2017-08-01 | 2017-08-02 | 13,920 | — | $0 | 0 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise deriv | 2017-08-01 | 2017-08-02 | 13,575 | — | $0 | 0 | SEC↗ |
| Gibertini Michael | Other | M Exercise deriv | 2017-08-01 | 2017-08-02 | 15,851 | — | $0 | 0 | SEC↗ |
| Gibertini Michael | Other | M Exercise deriv | 2017-08-01 | 2017-08-02 | 16,500 | — | $0 | 0 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | M Exercise deriv | 2017-08-01 | 2017-08-03 | 16,500 | — | $0 | 0 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | M Exercise deriv | 2017-08-01 | 2017-08-03 | 32,421 | — | $0 | 0 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | M Exercise | 2017-08-01 | 2017-08-02 | 12,000 | — | $0 | 78,296 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | M Exercise | 2017-08-01 | 2017-08-02 | 11,527 | — | $0 | 66,296 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise | 2017-08-01 | 2017-08-02 | 9,280 | — | $0 | 55,774 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise | 2017-08-01 | 2017-08-02 | 9,050 | — | $0 | 64,824 | SEC↗ |
| Gibertini Michael | Other | M Exercise | 2017-08-01 | 2017-08-02 | 11,000 | — | $0 | 78,360 | SEC↗ |
| Gibertini Michael | Other | M Exercise | 2017-08-01 | 2017-08-02 | 10,567 | — | $0 | 67,360 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | M Exercise | 2017-08-01 | 2017-08-03 | 11,000 | — | $0 | 105,994 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | M Exercise | 2017-08-01 | 2017-08-03 | 21,614 | — | $0 | 94,994 | SEC↗ |
| Bell Michael Adam | Exec Chair & Pres, Comm Div | F Tax w/h | 2017-08-01 | 2017-08-03 | 16,822 | $55.85 | $939.5K | 109,316 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | F Tax w/h | 2017-08-01 | 2017-08-03 | 4,193 | $55.85 | $234.2K | 101,801 | SEC↗ |
| Thomas H. Lee Parallel (Cayman | 10% Owner | A Award | 2017-08-01 | 2017-08-03 | 2,178 | — | $0 | 2,178 | SEC↗ |
| Thomas H. Lee Parallel (Cayman | 10% Owner | A Award | 2017-08-01 | 2017-08-03 | 2,178 | — | $0 | 2,178 | SEC↗ |
| THL Coinvestment Partners, L.P | 10% Owner | A Award | 2017-08-01 | 2017-08-03 | 2,178 | — | $0 | 2,178 | SEC↗ |
| THL Coinvestment Partners, L.P | 10% Owner | A Award | 2017-08-01 | 2017-08-03 | 2,178 | — | $0 | 2,178 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | S Sale | 2017-07-03 | 2017-07-05 | 1,088 | $58.55 | $63.7K | 73,380 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | S Sale | 2017-07-03 | 2017-07-05 | 956 | $58.55 | $56.0K | 46,494 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | M Exercise deriv | 2017-06-30 | 2017-07-05 | 9,467 | — | $0 | 37,868 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise deriv | 2017-06-30 | 2017-07-05 | 5,917 | — | $0 | 23,668 | SEC↗ |
| Gibertini Michael | Chief Operating Officer | F Tax w/h | 2017-06-30 | 2017-07-03 | 576 | $58.50 | $33.7K | 56,793 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | F Tax w/h | 2017-06-30 | 2017-07-03 | 967 | $58.50 | $56.6K | 54,769 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | S Sale | 2017-06-30 | 2017-07-05 | 9,467 | $58.36 | $552.5K | 74,468 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | M Exercise | 2017-06-30 | 2017-07-05 | 9,467 | $16.06 | $152.0K | 83,935 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise | 2017-06-30 | 2017-07-05 | 5,917 | $16.06 | $95.0K | 52,411 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | S Sale | 2017-06-30 | 2017-07-05 | 5,917 | $58.29 | $344.9K | 46,494 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | F Tax w/h | 2017-06-30 | 2017-07-05 | 867 | $58.50 | $50.7K | 47,450 | SEC↗ |
| Burgstahler David F | Director, 10% Owner | A Award | 2017-05-23 | 2017-05-24 | 2,693 | — | $0 | 38,758 | SEC↗ |
| Breckon Robert W | Director | A Award | 2017-05-23 | 2017-05-24 | 2,693 | — | $0 | 6,057 | SEC↗ |
| Harty Linda S | Director | A Award | 2017-05-23 | 2017-05-24 | 2,693 | — | $0 | 3,207 | SEC↗ |
| Kender Richard N | Director | A Award | 2017-05-23 | 2017-05-24 | 2,693 | — | $0 | 7,148 | SEC↗ |
| KLITGAARD WILLIAM E | Director | A Award | 2017-05-23 | 2017-05-24 | 2,693 | — | $0 | 3,207 | SEC↗ |
| Meyers Kenneth F | Director | A Award | 2017-05-23 | 2017-05-24 | 2,693 | — | $0 | 3,916 | SEC↗ |
| Monaghan Matthew E. | Director | A Award | 2017-05-23 | 2017-05-24 | 2,693 | — | $0 | 3,916 | SEC↗ |
| Norton David Y | Director | A Award | 2017-05-23 | 2017-05-24 | 2,693 | — | $0 | 6,988 | SEC↗ |
| Paques Eric | Director | A Award | 2017-05-23 | 2017-05-24 | 2,693 | — | $0 | 3,236 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | M Exercise deriv | 2017-05-01 | 2017-05-02 | 9,467 | — | $0 | 37,868 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | M Exercise | 2017-05-01 | 2017-05-02 | 9,467 | $16.06 | $152.0K | 83,935 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | S Sale | 2017-05-01 | 2017-05-02 | 9,467 | $45.00 | $426.0K | 74,468 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise deriv | 2017-04-03 | 2017-04-04 | 4,733 | — | $0 | 4,733 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise | 2017-04-03 | 2017-04-04 | 4,733 | $10.57 | $50.0K | 53,050 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | S Sale | 2017-04-03 | 2017-04-04 | 4,733 | $45.70 | $216.3K | 48,317 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | M Exercise deriv | 2017-03-03 | 2017-03-06 | 8,828 | — | $0 | 17,656 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | M Exercise | 2017-03-03 | 2017-03-06 | 8,828 | $10.57 | $93.3K | 83,296 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | S Sale | 2017-03-03 | 2017-03-06 | 8,828 | $45.00 | $397.3K | 74,468 | SEC↗ |
| Harty Linda S | Director | A Award | 2017-03-01 | 2017-03-03 | 514 | — | $0 | 514 | SEC↗ |
| KLITGAARD WILLIAM E | Director | A Award | 2017-03-01 | 2017-03-03 | 514 | — | $0 | 514 | SEC↗ |
| Paques Eric | Director | A Award | 2017-02-08 | 2017-02-10 | 543 | — | $0 | 543 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | A Award deriv | 2017-01-27 | 2017-01-30 | 32,421 | — | $0 | 32,421 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | A Award deriv | 2017-01-27 | 2017-01-30 | 17,291 | — | $0 | 17,291 | SEC↗ |
| Gibertini Michael | Chief Operating Officer | A Award deriv | 2017-01-27 | 2017-01-30 | 15,851 | — | $0 | 15,851 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | A Award deriv | 2017-01-27 | 2017-01-30 | 13,920 | — | $0 | 13,920 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | A Award | 2017-01-27 | 2017-01-30 | 21,614 | — | $0 | 74,468 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | A Award | 2017-01-27 | 2017-01-30 | 11,527 | — | $0 | 55,736 | SEC↗ |
| Gibertini Michael | Chief Operating Officer | A Award | 2017-01-27 | 2017-01-30 | 10,567 | — | $0 | 57,369 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | A Award | 2017-01-27 | 2017-01-30 | 9,280 | — | $0 | 48,317 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | S Sale | 2017-01-20 | 2017-01-23 | 1,375 | $50.50 | $69.4K | 52,854 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | S Sale | 2017-01-20 | 2017-01-23 | 1,573 | $50.50 | $79.4K | 44,209 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | S Sale | 2017-01-20 | 2017-01-23 | 1,186 | $50.09 | $59.4K | 39,037 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | M Exercise deriv | 2017-01-19 | 2017-01-23 | 1,334 | — | $0 | 3,999 | SEC↗ |
| Gibertini Michael | Chief Operating Officer | F Tax w/h | 2017-01-19 | 2017-01-20 | 837 | $50.55 | $42.3K | 46,802 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | F Tax w/h | 2017-01-19 | 2017-01-23 | 1,427 | $50.55 | $72.1K | 45,782 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | S Sale | 2017-01-19 | 2017-01-23 | 1,334 | $50.65 | $67.6K | 44,209 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | M Exercise | 2017-01-19 | 2017-01-23 | 1,334 | $42.88 | $57.2K | 45,543 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | F Tax w/h | 2017-01-19 | 2017-01-23 | 1,077 | $50.55 | $54.4K | 40,223 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | M Exercise deriv | 2017-01-05 | 2017-01-06 | 14,840 | — | $0 | 14,840 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | S Sale | 2017-01-05 | 2017-01-06 | 14,840 | $52.19 | $774.5K | 54,229 | SEC↗ |
| Macdonald Alistair | Chief Executive Officer | M Exercise | 2017-01-05 | 2017-01-06 | 14,840 | $8.45 | $125.4K | 69,069 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | M Exercise deriv | 2017-01-03 | 2017-01-04 | 35,503 | — | $0 | 106,508 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | M Exercise deriv | 2017-01-03 | 2017-01-04 | 5,917 | — | $0 | 29,585 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise deriv | 2017-01-03 | 2017-01-04 | 5,917 | — | $0 | 29,585 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise deriv | 2017-01-03 | 2017-01-04 | 4,733 | — | $0 | 14,200 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise deriv | 2017-01-03 | 2017-01-04 | 4,733 | — | $0 | 9,466 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | M Exercise | 2017-01-03 | 2017-01-04 | 35,503 | $10.06 | $357.2K | 82,712 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | M Exercise | 2017-01-03 | 2017-01-04 | 5,917 | $16.06 | $95.0K | 53,126 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | S Sale | 2017-01-03 | 2017-01-04 | 5,717 | $51.89 | $296.7K | 47,409 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | S Sale | 2017-01-03 | 2017-01-04 | 200 | $52.40 | $10.5K | 47,209 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | S Sale | 2017-01-03 | 2017-01-04 | 34,903 | $51.89 | $1.81M | 47,809 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | S Sale | 2017-01-03 | 2017-01-04 | 600 | $52.40 | $31.4K | 47,209 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise | 2017-01-03 | 2017-01-04 | 4,733 | $10.57 | $50.0K | 46,033 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | S Sale | 2017-01-03 | 2017-01-04 | 5,817 | $51.90 | $301.9K | 41,400 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | S Sale | 2017-01-03 | 2017-01-04 | 4,733 | $51.91 | $245.7K | 41,300 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise | 2017-01-03 | 2017-01-04 | 5,917 | $16.06 | $95.0K | 47,217 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | S Sale | 2017-01-03 | 2017-01-04 | 4,733 | $51.89 | $245.6K | 41,300 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise | 2017-01-03 | 2017-01-04 | 4,733 | $10.06 | $47.6K | 46,033 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | S Sale | 2017-01-03 | 2017-01-04 | 100 | $52.25 | $5.2K | 41,300 | SEC↗ |
| Meyers Kenneth F | Director | A Award | 2016-10-31 | 2016-11-01 | 1,223 | — | $0 | 1,223 | SEC↗ |
| Monaghan Matthew E. | Director | A Award | 2016-10-31 | 2016-11-01 | 1,223 | — | $0 | 1,223 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | M Exercise deriv | 2016-09-30 | 2016-10-03 | 35,503 | — | $0 | 142,011 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | S Sale | 2016-09-30 | 2016-10-03 | 35,503 | $44.70 | $1.59M | 47,209 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | M Exercise | 2016-09-30 | 2016-10-03 | 35,503 | $10.06 | $357.2K | 82,712 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | M Exercise deriv | 2016-09-27 | 2016-09-28 | 17,752 | — | $0 | 71,005 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | M Exercise deriv | 2016-09-27 | 2016-09-28 | 18,936 | — | $0 | 75,738 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | S Sale | 2016-09-27 | 2016-09-28 | 18,936 | $44.30 | $838.9K | 58,927 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | M Exercise | 2016-09-27 | 2016-09-28 | 18,936 | $16.06 | $304.1K | 77,863 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | S Sale | 2016-09-27 | 2016-09-28 | 17,752 | $44.31 | $786.6K | 58,927 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | M Exercise | 2016-09-27 | 2016-09-28 | 17,752 | $13.52 | $240.0K | 76,679 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | S Sale | 2016-09-27 | 2016-09-28 | 3,293 | $44.31 | $145.9K | 58,927 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | S Sale | 2016-09-27 | 2016-09-28 | 13,989 | $44.30 | $619.7K | 62,220 | SEC↗ |
| Breckon Robert W | Director | M Exercise deriv | 2016-09-26 | 2016-09-28 | 7,600 | — | $0 | 0 | SEC↗ |
| Breckon Robert W | Director | S Sale | 2016-09-26 | 2016-09-28 | 38 | $44.61 | $1.7K | 7,923 | SEC↗ |
| Breckon Robert W | Director | S Sale | 2016-09-26 | 2016-09-28 | 7,600 | $44.18 | $335.8K | 7,961 | SEC↗ |
| Breckon Robert W | Director | S Sale | 2016-09-26 | 2016-09-28 | 4,559 | $44.12 | $201.1K | 3,364 | SEC↗ |
| Breckon Robert W | Director | M Exercise | 2016-09-26 | 2016-09-28 | 7,600 | $8.45 | $64.2K | 15,561 | SEC↗ |
| Burgstahler David F | Director, 10% Owner | P Buy | 2016-09-19 | 2016-09-20 | 1,000 | $43.19 | $43.2K | 36,065 | SEC↗ |
| Gibertini Michael | President Clinical Developme | A Award | 2016-09-15 | 2016-09-16 | 29,110 | — | $0 | 47,639 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | A Award | 2016-09-15 | 2016-09-16 | 26,782 | — | $0 | 41,300 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | A Award | 2016-09-15 | 2016-09-16 | 29,110 | — | $0 | 47,209 | SEC↗ |
| Burgstahler David F | Director, 10% Owner | A Award | 2016-09-15 | 2016-09-16 | 1,729 | — | $0 | 35,065 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise deriv | 2016-09-14 | 2016-09-16 | 4,734 | — | $0 | 18,933 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise | 2016-09-14 | 2016-09-16 | 4,734 | $10.06 | $47.6K | 19,252 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | S Sale | 2016-09-14 | 2016-09-16 | 4,734 | $43.14 | $204.2K | 14,518 | SEC↗ |
| Harwood Charles C Jr | Director | J Other | 2016-08-24 | 2016-08-31 | 8,753 | — | $0 | 26,294 | SEC↗ |
| Burgstahler David F | Director | J Other | 2016-08-24 | 2016-09-01 | 3,648 | — | $0 | 3,648 | SEC↗ |
| Burgstahler David F | Director | J Other | 2016-08-24 | 2016-09-01 | 33,336 | — | $0 | 33,336 | SEC↗ |
| Macdonald Alistair | Chief Operating Officer | M Exercise deriv | 2016-08-17 | 2016-08-18 | 8,828 | — | $0 | 26,484 | SEC↗ |
| Macdonald Alistair | Chief Operating Officer | M Exercise | 2016-08-17 | 2016-08-18 | 8,828 | $10.57 | $93.3K | 63,057 | SEC↗ |
| Macdonald Alistair | Chief Operating Officer | S Sale | 2016-08-17 | 2016-08-18 | 8,828 | $43.80 | $386.7K | 54,229 | SEC↗ |
| INC Research Mezzanine Co-Inve | 10% Owner | S Sale | 2016-08-04 | 2016-08-05 | 2,554,409 | $42.06 | $107.44M | 4,119,676 | SEC↗ |
| 1829356 Ontario Ltd | Director, 10% Owner | S Sale | 2016-08-04 | 2016-08-05 | 2,445,591 | $42.06 | $102.86M | 3,944,174 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | M Exercise deriv | 2016-08-02 | 2016-08-03 | 31,279 | — | $0 | 59,170 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | M Exercise | 2016-08-02 | 2016-08-03 | 31,279 | $10.57 | $330.6K | 107,488 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | S Sale | 2016-08-02 | 2016-08-03 | 31,279 | $43.00 | $1.34M | 76,209 | SEC↗ |
| Macdonald Alistair | Chief Operating Officer | A Award deriv | 2016-08-01 | 2016-08-02 | 35,553 | — | $0 | 35,553 | SEC↗ |
| Breckon Robert W | Director | S Sale | 2016-08-01 | 2016-08-02 | 108 | $42.00 | $4.5K | 7,961 | SEC↗ |
| Macdonald Alistair | Chief Operating Officer | A Award | 2016-08-01 | 2016-08-02 | 35,553 | — | $0 | 54,229 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | M Exercise deriv | 2016-07-28 | 2016-07-29 | 4,066 | — | $0 | 12,198 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | S Sale | 2016-07-28 | 2016-07-29 | 4,066 | $45.23 | $183.9K | 18,099 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | M Exercise | 2016-07-28 | 2016-07-29 | 4,066 | $40.12 | $163.1K | 22,165 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | M Exercise deriv | 2016-07-20 | 2016-07-21 | 71,007 | — | $0 | 71,004 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | M Exercise deriv | 2016-07-20 | 2016-07-21 | 29,586 | — | $0 | 90,449 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | S Sale | 2016-07-20 | 2016-07-21 | 29,586 | $43.00 | $1.27M | 76,209 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | M Exercise | 2016-07-20 | 2016-07-21 | 71,007 | $10.57 | $750.5K | 147,216 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | S Sale | 2016-07-20 | 2016-07-21 | 71,007 | $43.00 | $3.05M | 76,209 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | M Exercise | 2016-07-20 | 2016-07-21 | 29,586 | $10.57 | $312.7K | 105,795 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | M Exercise deriv | 2016-07-15 | 2016-07-18 | 5,917 | — | $0 | 35,502 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | M Exercise | 2016-07-15 | 2016-07-18 | 5,917 | $16.06 | $95.0K | 24,016 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | S Sale | 2016-07-15 | 2016-07-18 | 5,917 | $41.50 | $245.6K | 18,099 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise deriv | 2016-07-11 | 2016-07-12 | 17,795 | — | $0 | 35,502 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise deriv | 2016-07-11 | 2016-07-12 | 2,906 | — | $0 | 14,199 | SEC↗ |
| Macdonald Alistair | Chief Operating Officer | M Exercise deriv | 2016-07-11 | 2016-07-12 | 9,468 | — | $0 | 56,802 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | S Sale | 2016-07-11 | 2016-07-12 | 2,906 | $40.25 | $117.0K | 15,735 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | S Sale | 2016-07-11 | 2016-07-12 | 17,795 | $40.19 | $715.2K | 15,735 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise | 2016-07-11 | 2016-07-12 | 2,906 | $10.57 | $30.7K | 18,641 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise | 2016-07-11 | 2016-07-12 | 17,795 | $16.06 | $285.8K | 33,530 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | S Sale | 2016-07-11 | 2016-07-12 | 1,217 | $40.18 | $48.9K | 14,518 | SEC↗ |
| Macdonald Alistair | Chief Operating Officer | M Exercise | 2016-07-11 | 2016-07-12 | 9,468 | $16.06 | $152.1K | 28,144 | SEC↗ |
| Macdonald Alistair | Chief Operating Officer | S Sale | 2016-07-11 | 2016-07-12 | 9,468 | $40.19 | $380.5K | 18,676 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | S Sale | 2016-07-01 | 2016-07-05 | 1,358 | $37.97 | $51.6K | 18,099 | SEC↗ |
| Breckon Robert W | Director | S Sale | 2016-07-01 | 2016-07-05 | 421 | $37.97 | $16.0K | 8,069 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | F Tax w/h | 2016-06-30 | 2016-07-01 | 3,017 | $38.13 | $115.0K | 76,209 | SEC↗ |
| Macdonald Alistair | Chief Operating Officer | F Tax w/h | 2016-06-30 | 2016-07-01 | 1,023 | $38.13 | $39.0K | 18,676 | SEC↗ |
| Gibertini Michael | President Clinical Developme | F Tax w/h | 2016-06-30 | 2016-07-01 | 883 | $38.13 | $33.7K | 18,529 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | F Tax w/h | 2016-06-30 | 2016-07-01 | 606 | $38.13 | $23.1K | 15,735 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | F Tax w/h | 2016-06-30 | 2016-07-05 | 675 | $38.13 | $25.7K | 19,457 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise deriv | 2016-06-15 | 2016-06-16 | 728 | — | $0 | 17,105 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise deriv | 2016-06-15 | 2016-06-16 | 3,928 | — | $0 | 53,297 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | S Sale | 2016-06-15 | 2016-06-16 | 3,928 | $40.16 | $157.7K | 16,341 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise | 2016-06-15 | 2016-06-16 | 728 | $10.57 | $7.7K | 17,069 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | S Sale | 2016-06-15 | 2016-06-16 | 728 | $40.22 | $29.3K | 16,341 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise | 2016-06-15 | 2016-06-16 | 3,928 | $16.06 | $63.1K | 20,269 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise deriv | 2016-06-14 | 2016-06-16 | 1,100 | — | $0 | 17,833 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise deriv | 2016-06-14 | 2016-06-16 | 1,946 | — | $0 | 57,225 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise | 2016-06-14 | 2016-06-16 | 1,100 | $10.57 | $11.6K | 17,441 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | S Sale | 2016-06-14 | 2016-06-16 | 1,100 | $40.05 | $44.1K | 16,341 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | M Exercise | 2016-06-14 | 2016-06-16 | 1,946 | $16.06 | $31.3K | 18,287 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | S Sale | 2016-06-14 | 2016-06-16 | 1,946 | $40.11 | $78.1K | 16,341 | SEC↗ |
| Gibertini Michael | President Clinical Developme | M Exercise deriv | 2016-06-06 | 2016-06-07 | 17,752 | — | $0 | 41,419 | SEC↗ |
| Gibertini Michael | President Clinical Developme | M Exercise deriv | 2016-06-06 | 2016-06-07 | 14,628 | — | $0 | 9,750 | SEC↗ |
| Gibertini Michael | President Clinical Developme | M Exercise deriv | 2016-06-06 | 2016-06-07 | 153,716 | — | $0 | 51,928 | SEC↗ |
| Gibertini Michael | President Clinical Developme | M Exercise | 2016-06-06 | 2016-06-07 | 14,628 | $10.57 | $154.6K | 61,910 | SEC↗ |
| Gibertini Michael | President Clinical Developme | S Sale | 2016-06-06 | 2016-06-07 | 9,034 | $43.83 | $396.0K | 47,282 | SEC↗ |
| Gibertini Michael | President Clinical Developme | S Sale | 2016-06-06 | 2016-06-07 | 144,682 | $43.05 | $6.23M | 56,316 | SEC↗ |
| Gibertini Michael | President Clinical Developme | M Exercise | 2016-06-06 | 2016-06-07 | 153,716 | $8.45 | $1.30M | 200,998 | SEC↗ |
| Gibertini Michael | President Clinical Developme | S Sale | 2016-06-06 | 2016-06-07 | 16,652 | $43.05 | $716.9K | 48,382 | SEC↗ |
| Gibertini Michael | President Clinical Developme | S Sale | 2016-06-06 | 2016-06-07 | 26,394 | $43.05 | $1.14M | 20,888 | SEC↗ |
| Gibertini Michael | President Clinical Developme | S Sale | 2016-06-06 | 2016-06-07 | 1,100 | $43.76 | $48.1K | 47,282 | SEC↗ |
| Gibertini Michael | President Clinical Developme | S Sale | 2016-06-06 | 2016-06-07 | 13,751 | $43.19 | $593.9K | 48,159 | SEC↗ |
| Gibertini Michael | President Clinical Developme | S Sale | 2016-06-06 | 2016-06-07 | 877 | $43.82 | $38.4K | 47,282 | SEC↗ |
| Gibertini Michael | President Clinical Developme | M Exercise | 2016-06-06 | 2016-06-07 | 17,752 | $16.06 | $285.1K | 65,034 | SEC↗ |
| Gibertini Michael | President Clinical Developme | S Sale | 2016-06-06 | 2016-06-07 | 1,476 | $43.84 | $64.7K | 19,412 | SEC↗ |
| Breckon Robert W | Director | S Sale | 2016-06-02 | 2016-06-03 | 2,173 | $43.46 | $94.4K | 8,490 | SEC↗ |
| Breckon Robert W | Director | M Exercise deriv | 2016-06-01 | 2016-06-03 | 9,047 | — | $0 | 0 | SEC↗ |
| Breckon Robert W | Director | M Exercise deriv | 2016-06-01 | 2016-06-03 | 471 | — | $0 | 7,600 | SEC↗ |
| Breckon Robert W | Director | M Exercise | 2016-06-01 | 2016-06-03 | 9,047 | $8.45 | $76.4K | 19,710 | SEC↗ |
| Breckon Robert W | Director | S Sale | 2016-06-01 | 2016-06-03 | 9,047 | $43.55 | $394.0K | 10,663 | SEC↗ |
| Breckon Robert W | Director | M Exercise | 2016-06-01 | 2016-06-03 | 471 | $8.45 | $4.0K | 11,134 | SEC↗ |
| Breckon Robert W | Director | S Sale | 2016-06-01 | 2016-06-03 | 471 | $43.55 | $20.5K | 10,663 | SEC↗ |
| Breckon Robert W | Director | A Award | 2016-05-24 | 2016-05-25 | 2,231 | — | $0 | 10,663 | SEC↗ |
| Harwood Charles C Jr | Director | A Award | 2016-05-24 | 2016-05-25 | 2,231 | — | $0 | 17,541 | SEC↗ |
| Kender Richard N | Director | A Award | 2016-05-24 | 2016-05-25 | 2,231 | — | $0 | 4,455 | SEC↗ |
| Norton David Y | Director | A Award | 2016-05-24 | 2016-05-25 | 2,231 | — | $0 | 4,295 | SEC↗ |
| Ogle James T. | Director | A Award | 2016-05-24 | 2016-05-25 | 2,231 | — | $0 | 180,617 | SEC↗ |
| ACP INC Research Co-Invest, LL | 10% Owner | S Sale | 2016-05-06 | 2016-05-09 | 4,087,054 | $45.12 | $184.41M | 6,674,085 | SEC↗ |
| 1829356 Ontario Ltd | Director, 10% Owner | S Sale | 2016-05-06 | 2016-05-09 | 3,912,946 | $45.12 | $176.55M | 6,389,765 | SEC↗ |
| Ogle James T. | Director | M Exercise deriv | 2016-04-18 | 2016-04-19 | 114,806 | — | $0 | 0 | SEC↗ |
| Ogle James T. | Director | S Sale | 2016-04-18 | 2016-04-19 | 114,806 | $50.00 | $5.74M | 178,386 | SEC↗ |
| Ogle James T. | Director | M Exercise | 2016-04-18 | 2016-04-19 | 114,806 | $8.45 | $970.1K | 293,192 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | M Exercise deriv | 2016-04-12 | 2016-04-14 | 59,172 | — | $0 | 120,035 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | M Exercise deriv | 2016-04-12 | 2016-04-14 | 35,503 | — | $0 | 142,011 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | S Sale | 2016-04-12 | 2016-04-14 | 59,172 | $48.00 | $2.84M | 79,226 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | M Exercise | 2016-04-12 | 2016-04-14 | 59,172 | $10.57 | $625.4K | 138,398 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | M Exercise | 2016-04-12 | 2016-04-14 | 35,503 | $10.57 | $375.3K | 114,729 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | S Sale | 2016-04-12 | 2016-04-14 | 35,503 | $48.00 | $1.70M | 79,226 | SEC↗ |
| Gibertini Michael | President Clinical Developme | M Exercise deriv | 2016-04-01 | 2016-04-04 | 9,000 | — | $0 | 205,644 | SEC↗ |
| Gibertini Michael | President Clinical Developme | M Exercise | 2016-04-01 | 2016-04-04 | 9,000 | $8.45 | $76.0K | 56,282 | SEC↗ |
| Gibertini Michael | President Clinical Developme | S Sale | 2016-04-01 | 2016-04-04 | 9,000 | $40.78 | $367.0K | 47,282 | SEC↗ |
| Gibertini Michael | President Clinical Developme | M Exercise deriv | 2016-03-01 | 2016-03-02 | 9,000 | — | $0 | 214,644 | SEC↗ |
| Gibertini Michael | President Clinical Developme | M Exercise | 2016-03-01 | 2016-03-02 | 9,000 | $8.45 | $76.0K | 56,282 | SEC↗ |
| Gibertini Michael | President Clinical Developme | S Sale | 2016-03-01 | 2016-03-02 | 9,000 | $39.85 | $358.6K | 47,282 | SEC↗ |
| Breckon Robert W | Director | M Exercise deriv | 2016-02-04 | 2016-02-05 | 2,787 | — | $0 | 9,047 | SEC↗ |
| Breckon Robert W | Director | S Sale | 2016-02-04 | 2016-02-05 | 421 | $40.00 | $16.8K | 8,432 | SEC↗ |
| Breckon Robert W | Director | S Sale | 2016-02-04 | 2016-02-05 | 2,366 | $40.70 | $96.3K | 8,853 | SEC↗ |
| Breckon Robert W | Director | M Exercise | 2016-02-04 | 2016-02-05 | 2,787 | $8.45 | $23.6K | 11,219 | SEC↗ |
| Breckon Robert W | Director | S Sale | 2016-02-04 | 2016-02-05 | 1,095 | $38.58 | $42.2K | 8,432 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | M Exercise deriv | 2016-02-01 | 2016-02-02 | 17,752 | — | $0 | 41,419 | SEC↗ |
| Gibertini Michael | President Clinical Developme | M Exercise deriv | 2016-02-01 | 2016-02-02 | 9,000 | — | $0 | 223,644 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | S Sale | 2016-02-01 | 2016-02-02 | 1,752 | $41.56 | $72.8K | 20,132 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | S Sale | 2016-02-01 | 2016-02-02 | 16,000 | $40.13 | $642.1K | 21,884 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | M Exercise | 2016-02-01 | 2016-02-02 | 17,752 | $16.06 | $285.1K | 37,884 | SEC↗ |
| Gibertini Michael | President Clinical Developme | S Sale | 2016-02-01 | 2016-02-02 | 1,000 | $41.56 | $41.6K | 47,282 | SEC↗ |
| Gibertini Michael | President Clinical Developme | S Sale | 2016-02-01 | 2016-02-02 | 8,000 | $40.45 | $323.6K | 48,282 | SEC↗ |
| Gibertini Michael | President Clinical Developme | M Exercise | 2016-02-01 | 2016-02-02 | 9,000 | $8.45 | $76.0K | 56,282 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | A Award deriv | 2016-01-19 | 2016-01-21 | 18,000 | — | $0 | 18,000 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | A Award deriv | 2016-01-19 | 2016-01-21 | 5,333 | — | $0 | 5,333 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | A Award deriv | 2016-01-19 | 2016-01-21 | 13,575 | — | $0 | 13,575 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | A Award deriv | 2016-01-19 | 2016-01-21 | 4,022 | — | $0 | 4,022 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | A Award deriv | 2016-01-19 | 2016-01-21 | 17,778 | — | $0 | 17,778 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | A Award deriv | 2016-01-19 | 2016-01-21 | 60,000 | — | $0 | 60,000 | SEC↗ |
| Macdonald Alistair | Chief Operating Officer | A Award deriv | 2016-01-19 | 2016-01-21 | 16,500 | — | $0 | 16,500 | SEC↗ |
| Macdonald Alistair | Chief Operating Officer | A Award deriv | 2016-01-19 | 2016-01-21 | 4,889 | — | $0 | 4,889 | SEC↗ |
| Gibertini Michael | President Clinical Developme | A Award deriv | 2016-01-19 | 2016-01-21 | 4,889 | — | $0 | 4,889 | SEC↗ |
| Gibertini Michael | President Clinical Developme | A Award deriv | 2016-01-19 | 2016-01-21 | 16,500 | — | $0 | 16,500 | SEC↗ |
| Rush Gregory S | Executive VP and CFO | A Award | 2016-01-19 | 2016-01-21 | 12,000 | — | $0 | 20,132 | SEC↗ |
| Gaenzle Christopher L | CAO, GC & Sec | A Award | 2016-01-19 | 2016-01-21 | 9,050 | — | $0 | 16,341 | SEC↗ |
| Macdonald D. Jamie | Chief Executive Officer | A Award | 2016-01-19 | 2016-01-21 | 40,000 | — | $0 | 79,226 | SEC↗ |
| Macdonald Alistair | Chief Operating Officer | A Award | 2016-01-19 | 2016-01-21 | 11,000 | — | $0 | 19,699 | SEC↗ |
| Gibertini Michael | President Clinical Developme | A Award | 2016-01-19 | 2016-01-21 | 11,000 | — | $0 | 47,282 | SEC↗ |
| Gibertini Michael | President Clinical Developme | M Exercise deriv | 2016-01-04 | 2016-01-06 | 9,000 | — | $0 | 232,644 | SEC↗ |
| Gibertini Michael | President Clinical Developme | S Sale | 2016-01-04 | 2016-01-06 | 3,100 | $47.52 | $147.3K | 36,282 | SEC↗ |
| Gibertini Michael | President Clinical Developme | S Sale | 2016-01-04 | 2016-01-06 | 5,900 | $46.47 | $274.2K | 39,382 | SEC↗ |
| Gibertini Michael | President Clinical Developme | M Exercise | 2016-01-04 | 2016-01-06 | 9,000 | $8.45 | $76.0K | 45,282 | SEC↗ |
| Macdonald Alistair | Chief Operating Officer | M Exercise deriv | 2015-12-31 | 2016-01-04 | 52,972 | — | $0 | 35,312 | SEC↗ |
| Macdonald Alistair | Chief Operating Officer | M Exercise deriv | 2015-12-31 | 2016-01-04 | 31,241 | — | $0 | 29,680 | SEC↗ |
| Macdonald Alistair | Chief Operating Officer | M Exercise deriv | 2015-12-31 | 2016-01-04 | 28,404 | — | $0 | 66,270 | SEC↗ |