Open-mkt buys · 90d
—
0 trades · 0 insiders
Open-mkt sales · 90d
—
0 trades · 0 insiders
Net · 90d
$0
Insiders on file
42
Daily buy vs sell · 90 days
No data yet.
Insiders
| Insider | Role | Trades | Bought | Sold | Last trade |
|---|---|---|---|---|---|
| Perkins Adelene Q | See Remarks | 46 | $0 | $2.62M | 2023-09-12 |
| Peluso Stephane | Chief Scientific Officer | 6 | $0 | $9.9K | 2022-08-02 |
| Agresta Samuel | Director | 6 | $0 | $0 | 2022-06-16 |
| GAYNOR RICHARD | Director | 3 | $0 | $0 | 2022-06-16 |
| SCHWARTZ BRIAN | Director | 3 | $0 | $0 | 2022-06-16 |
| EVNIN ANTHONY B | Director | 64 | $0 | $4.78M | 2022-06-16 |
| SELBY NORMAN C | Director | 37 | $0 | $0 | 2022-06-16 |
| BEIER DAVID W | Director | 7 | $0 | $0 | 2022-06-16 |
| KANGO SUJAY | Director | 8 | $0 | $95.9K | 2022-03-30 |
| Ilaria Robert Jr. | Chief Medical Officer | 2 | $0 | $0 | 2022-01-11 |
| Tasker Seth A | General Counsel | 11 | $0 | $0 | 2022-01-11 |
| BLOCH LAWRENCE E | President | 18 | $905.0K | $0 | 2022-01-11 |
| BVF INC/IL | 10% Owner | 21 | $3.00M | $12.14M | 2021-02-11 |
| BIOTECHNOLOGY VALUE FUND L P | Other | 3 | $0 | $24.21M | 2021-01-22 |
| VENUTI MICHAEL C | Director | 20 | $0 | $21.8K | 2020-06-17 |
| Kutok Jeffery | Chief Scientific Officer | 10 | $0 | $57.3K | 2020-01-10 |
| Berkowitz Jeffrey | Director | 12 | $0 | $0 | 2019-06-13 |
| Kauffman Michael | Director | 3 | $0 | $0 | 2019-06-13 |
| BIOTECHNOLOGY VALUE FUND II LP | 10% Owner | 13 | $1.44M | $0 | 2018-12-13 |
| BVF Partners OS Ltd. | Other | 12 | $4.19M | $0 | 2018-11-15 |
| BVF PARTNERS L P/IL | 10% Owner | 8 | $6.51M | $0 | 2018-06-21 |
| SMITH IAN F | Director | 17 | $0 | $0 | 2018-06-12 |
| Biotechnology Value Trading Fund OS LP | Other | 6 | $2.01M | $0 | 2017-10-04 |
| Baselga Jose | Director | 4 | $0 | $0 | 2017-01-06 |
| ADAMS JULIAN | President of R&D | 6 | $0 | $0 | 2016-10-31 |
| LANDER ERIC S | Director | 7 | $0 | $0 | 2016-06-17 |
| Lindblom Christopher M | See Remarks | 8 | $0 | $357.3K | 2016-05-02 |
| Bertrand William C JR | General Counsel | 1 | $0 | $0 | 2015-10-19 |
| Fyfe Gwen A. | Director | 5 | $0 | $0 | 2015-06-15 |
| Palombella Vito J. | Chief Scientific Officer | 31 | $0 | $949.4K | 2015-06-15 |
| Lam Winston K.C. | General Counsel | 1 | $0 | $0 | 2015-04-15 |
| Roth David | Chief Medical Officer | 1 | $0 | $0 | 2015-01-14 |
| Santabarbara Pedro | Chief Medical Officer | 5 | $0 | $0 | 2014-01-10 |
| Lynch Thomas J. Jr. | Director | 2 | $0 | $0 | 2013-06-11 |
| Babler Martin | Director | 3 | $0 | $0 | 2013-06-11 |
| Rosebay Medical Co L.P. | 10% Owner | 5 | $78.54M | $219.20M | 2013-04-16 |
| Beacon Co | 10% Owner | 5 | $78.54M | $219.20M | 2013-04-16 |
| Tucker Winselow S. Jr. | Vice President, Marketing | 2 | $0 | $0 | 2013-01-04 |
| Hamermesh Joshua | VP, Business & Corporate Dev | 2 | $0 | $0 | 2013-01-04 |
| Holtzman Steven H | Director | 6 | $0 | $3.35M | 2012-05-31 |
| Lee Patrick Pak-Tin | Director | 1 | $0 | $0 | 2012-05-16 |
| Quirk Gerald E | See Remarks | 1 | $0 | $0 | 2012-01-06 |
Trade history
| Insider | Role | Code | Trade | Filed | Shares | Price | Value | Owned after | |
|---|---|---|---|---|---|---|---|---|---|
| Perkins Adelene Q | Director | S Sale | 2023-09-12 | 2023-09-12 | 410,196 | $0.07 | $28.7K | 1,175,291 | SEC↗ |
| Perkins Adelene Q | Director | M Exercise deriv | 2023-09-09 | 2023-09-12 | 768,133 | — | $0 | 0 | SEC↗ |
| Perkins Adelene Q | Director | M Exercise | 2023-09-09 | 2023-09-12 | 768,133 | — | $0 | 1,585,487 | SEC↗ |
| Peluso Stephane | Chief Scientific Officer | M Exercise deriv | 2022-08-02 | 2022-08-04 | 50,000 | — | $0 | 0 | SEC↗ |
| Peluso Stephane | Chief Scientific Officer | M Exercise | 2022-08-02 | 2022-08-04 | 50,000 | — | $0 | 52,046 | SEC↗ |
| Peluso Stephane | Chief Scientific Officer | S Sale | 2022-08-02 | 2022-08-04 | 14,994 | $0.66 | $9.9K | 37,052 | SEC↗ |
| SCHWARTZ BRIAN | Director | A Award deriv | 2022-06-16 | 2022-06-16 | 45,000 | — | $0 | 45,000 | SEC↗ |
| SELBY NORMAN C | Director | A Award deriv | 2022-06-16 | 2022-06-16 | 45,000 | — | $0 | 45,000 | SEC↗ |
| SELBY NORMAN C | Director | A Award deriv | 2022-06-16 | 2022-06-16 | 10,000 | — | $0 | 10,000 | SEC↗ |
| Agresta Samuel | Director | A Award deriv | 2022-06-16 | 2022-06-16 | 45,000 | — | $0 | 45,000 | SEC↗ |
| GAYNOR RICHARD | Director | A Award deriv | 2022-06-16 | 2022-06-16 | 45,000 | — | $0 | 45,000 | SEC↗ |
| BEIER DAVID W | Director | A Award deriv | 2022-06-16 | 2022-06-16 | 45,000 | — | $0 | 45,000 | SEC↗ |
| EVNIN ANTHONY B | Director | A Award deriv | 2022-06-16 | 2022-06-16 | 45,000 | — | $0 | 45,000 | SEC↗ |
| SCHWARTZ BRIAN | Director | A Award | 2022-06-16 | 2022-06-16 | 30,919 | $0.68 | $21.0K | 30,919 | SEC↗ |
| EVNIN ANTHONY B | Director | A Award | 2022-06-16 | 2022-06-16 | 46,378 | $0.68 | $31.5K | 215,403 | SEC↗ |
| KANGO SUJAY | Director | A Award deriv | 2022-03-30 | 2022-03-31 | 90,000 | — | $0 | 90,000 | SEC↗ |
| Ilaria Robert Jr. | Chief Medical Officer | A Award deriv | 2022-01-11 | 2022-01-12 | 87,472 | — | $0 | 87,472 | SEC↗ |
| Peluso Stephane | Chief Scientific Officer | A Award deriv | 2022-01-11 | 2022-01-12 | 87,027 | — | $0 | 87,027 | SEC↗ |
| Tasker Seth A | Chief Business Officer | A Award deriv | 2022-01-11 | 2022-01-12 | 225,000 | — | $0 | 225,000 | SEC↗ |
| BLOCH LAWRENCE E | President | A Award deriv | 2022-01-11 | 2022-01-12 | 335,000 | — | $0 | 335,000 | SEC↗ |
| Perkins Adelene Q | Chief Executive Officer | A Award deriv | 2022-01-11 | 2022-01-12 | 576,100 | — | $0 | 576,100 | SEC↗ |
| SCHWARTZ BRIAN | Director | A Award deriv | 2021-09-07 | 2021-09-10 | 60,000 | — | $0 | 60,000 | SEC↗ |
| Ilaria Robert Jr. | Chief Medical Officer | A Award deriv | 2021-09-01 | 2021-09-03 | 300,000 | — | $0 | 300,000 | SEC↗ |
| Peluso Stephane | Chief Scientific Officer | A Award deriv | 2021-08-02 | 2021-08-03 | 250,000 | — | $0 | 250,000 | SEC↗ |
| Peluso Stephane | Chief Scientific Officer | A Award deriv | 2021-08-02 | 2021-08-03 | 50,000 | — | $0 | 50,000 | SEC↗ |
| EVNIN ANTHONY B | Director | A Award deriv | 2021-06-10 | 2021-06-11 | 30,000 | — | $0 | 30,000 | SEC↗ |
| GAYNOR RICHARD | Director | A Award deriv | 2021-06-10 | 2021-06-11 | 30,000 | — | $0 | 30,000 | SEC↗ |
| SELBY NORMAN C | Director | A Award deriv | 2021-06-10 | 2021-06-11 | 10,000 | — | $0 | 10,000 | SEC↗ |
| SELBY NORMAN C | Director | A Award deriv | 2021-06-10 | 2021-06-11 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Agresta Samuel | Director | A Award deriv | 2021-06-10 | 2021-06-11 | 30,000 | — | $0 | 30,000 | SEC↗ |
| BEIER DAVID W | Director | A Award deriv | 2021-06-10 | 2021-06-11 | 30,000 | — | $0 | 30,000 | SEC↗ |
| EVNIN ANTHONY B | Director | A Award | 2021-06-10 | 2021-06-11 | 3,061 | $3.43 | $10.5K | 169,025 | SEC↗ |
| BEIER DAVID W | Director | A Award | 2021-06-10 | 2021-06-11 | 3,061 | $3.43 | $10.5K | 8,775 | SEC↗ |
| SELBY NORMAN C | Director | M Exercise deriv | 2021-05-14 | 2021-05-18 | 5,000 | — | $0 | 35,000 | SEC↗ |
| SELBY NORMAN C | Director | M Exercise | 2021-05-14 | 2021-05-18 | 5,000 | $0.92 | $4.6K | 15,000 | SEC↗ |
| BVF INC/IL | 10% Owner | S Sale | 2021-02-11 | 2021-02-16 | 1,215,491 | $5.37 | $6.53M | 4,448,421 | SEC↗ |
| BVF INC/IL | 10% Owner | S Sale | 2021-02-11 | 2021-02-16 | 152,127 | $5.37 | $816.9K | 534,847 | SEC↗ |
| BVF INC/IL | 10% Owner | S Sale | 2021-02-11 | 2021-02-16 | 892,467 | $5.37 | $4.79M | 3,279,831 | SEC↗ |
| BIOTECHNOLOGY VALUE FUND L P | Other | S Sale | 2021-01-22 | 2021-01-26 | 2,458,838 | $4.14 | $10.18M | 4,172,298 | SEC↗ |
| BIOTECHNOLOGY VALUE FUND L P | Other | S Sale | 2021-01-22 | 2021-01-26 | 2,821,663 | $4.14 | $11.68M | 5,663,912 | SEC↗ |
| BIOTECHNOLOGY VALUE FUND L P | Other | S Sale | 2021-01-22 | 2021-01-26 | 568,019 | $4.14 | $2.35M | 686,974 | SEC↗ |
| Perkins Adelene Q | Chief Executive Officer | A Award deriv | 2020-12-22 | 2020-12-23 | 485,000 | — | $0 | 485,000 | SEC↗ |
| BLOCH LAWRENCE E | President | A Award deriv | 2020-12-22 | 2020-12-23 | 335,000 | — | $0 | 335,000 | SEC↗ |
| Tasker Seth A | Chief Business Officer | A Award deriv | 2020-12-22 | 2020-12-23 | 250,000 | — | $0 | 250,000 | SEC↗ |
| Agresta Samuel | Director | A Award deriv | 2020-10-16 | 2019-10-16 | 60,000 | — | $0 | 60,000 | SEC↗ |
| EVNIN ANTHONY B | Director | A Award deriv | 2020-06-17 | 2020-06-18 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Agresta Samuel | Director | A Award deriv | 2020-06-17 | 2020-06-18 | 30,000 | — | $0 | 30,000 | SEC↗ |
| BEIER DAVID W | Director | A Award deriv | 2020-06-17 | 2020-06-18 | 30,000 | — | $0 | 30,000 | SEC↗ |
| SELBY NORMAN C | Director | A Award deriv | 2020-06-17 | 2020-06-18 | 10,000 | — | $0 | 10,000 | SEC↗ |
| SELBY NORMAN C | Director | A Award deriv | 2020-06-17 | 2020-06-18 | 30,000 | — | $0 | 30,000 | SEC↗ |
| VENUTI MICHAEL C | Director | A Award deriv | 2020-06-17 | 2020-06-18 | 30,000 | — | $0 | 30,000 | SEC↗ |
| EVNIN ANTHONY B | Director | A Award | 2020-06-17 | 2020-06-18 | 22,826 | — | $0 | 165,964 | SEC↗ |
| GAYNOR RICHARD | Director | A Award deriv | 2020-03-16 | 2020-03-17 | 60,000 | — | $0 | 60,000 | SEC↗ |
| Perkins Adelene Q | Chief Executive Officer | A Award deriv | 2020-01-10 | 2020-01-13 | 606,250 | — | $0 | 606,250 | SEC↗ |
| Kutok Jeffery | Chief Scientific Officer | A Award deriv | 2020-01-10 | 2020-01-13 | 450,000 | — | $0 | 450,000 | SEC↗ |
| BLOCH LAWRENCE E | President | A Award deriv | 2020-01-10 | 2020-01-13 | 418,750 | — | $0 | 418,750 | SEC↗ |
| Tasker Seth A | Chief Business Officer | A Award deriv | 2020-01-10 | 2020-01-13 | 412,500 | — | $0 | 412,500 | SEC↗ |
| Perkins Adelene Q | Chief Executive Officer | A Award | 2020-01-10 | 2020-01-13 | 155,134 | — | $0 | 793,190 | SEC↗ |
| Kutok Jeffery | Chief Scientific Officer | A Award | 2020-01-10 | 2020-01-13 | 64,219 | — | $0 | 77,376 | SEC↗ |
| BLOCH LAWRENCE E | President | A Award | 2020-01-10 | 2020-01-13 | 83,157 | — | $0 | 745,094 | SEC↗ |
| Tasker Seth A | Chief Business Officer | A Award | 2020-01-10 | 2020-01-13 | 53,538 | — | $0 | 101,364 | SEC↗ |
| Berkowitz Jeffrey | Director | A Award deriv | 2019-06-13 | 2019-06-14 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Perkins Adelene Q | Chief Executive Officer | A Award deriv | 2019-06-13 | 2019-06-14 | 242,000 | — | $0 | 242,000 | SEC↗ |
| Kauffman Michael | Director | A Award deriv | 2019-06-13 | 2019-06-14 | 30,000 | — | $0 | 30,000 | SEC↗ |
| BLOCH LAWRENCE E | President | A Award deriv | 2019-06-13 | 2019-06-14 | 100,000 | — | $0 | 100,000 | SEC↗ |
| VENUTI MICHAEL C | Director | A Award deriv | 2019-06-13 | 2019-06-14 | 30,000 | — | $0 | 30,000 | SEC↗ |
| BEIER DAVID W | Director | A Award deriv | 2019-06-13 | 2019-06-14 | 30,000 | — | $0 | 30,000 | SEC↗ |
| SELBY NORMAN C | Director | A Award deriv | 2019-06-13 | 2019-06-14 | 30,000 | — | $0 | 0 | SEC↗ |
| SELBY NORMAN C | Director | A Award deriv | 2019-06-13 | 2019-06-14 | 10,000 | — | $0 | 0 | SEC↗ |
| EVNIN ANTHONY B | Director | A Award deriv | 2019-06-13 | 2019-06-14 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Berkowitz Jeffrey | Director | A Award | 2019-06-13 | 2019-06-14 | 26,250 | $1.60 | $42.0K | 85,238 | SEC↗ |
| EVNIN ANTHONY B | Director | A Award | 2019-06-13 | 2019-06-14 | 13,125 | $1.60 | $21.0K | 143,138 | SEC↗ |
| Perkins Adelene Q | Chief Executive Officer | A Award deriv | 2019-01-04 | 2019-01-07 | 243,000 | — | $0 | 243,000 | SEC↗ |
| Agresta Samuel | Chief Medical Officer | A Award deriv | 2019-01-04 | 2019-01-07 | 62,596 | — | $0 | 62,596 | SEC↗ |
| Kutok Jeffery | Chief Scientific Officer | A Award deriv | 2019-01-04 | 2019-01-07 | 155,000 | — | $0 | 155,000 | SEC↗ |
| BLOCH LAWRENCE E | President | A Award deriv | 2019-01-04 | 2019-01-07 | 335,000 | — | $0 | 335,000 | SEC↗ |
| Tasker Seth A | General Counsel | A Award deriv | 2019-01-04 | 2019-01-07 | 140,000 | — | $0 | 140,000 | SEC↗ |
| BIOTECHNOLOGY VALUE FUND II LP | 10% Owner | P Buy | 2018-12-13 | 2018-12-17 | 120,539 | $1.20 | $144.6K | 6,631,136 | SEC↗ |
| BIOTECHNOLOGY VALUE FUND II LP | 10% Owner | P Buy | 2018-12-13 | 2018-12-17 | 54,461 | $1.20 | $65.4K | 8,485,575 | SEC↗ |
| BVF INC/IL | 10% Owner | P Buy | 2018-11-28 | 2018-11-30 | 100,000 | $1.30 | $130.0K | 6,510,597 | SEC↗ |
| BVF INC/IL | 10% Owner | P Buy | 2018-11-21 | 2018-11-21 | 4,119 | $1.35 | $5.6K | 8,431,114 | SEC↗ |
| BVF INC/IL | 10% Owner | P Buy | 2018-11-21 | 2018-11-21 | 581 | $1.35 | $784 | 1,254,993 | SEC↗ |
| BVF INC/IL | 10% Owner | P Buy | 2018-11-19 | 2018-11-21 | 50,044 | $1.35 | $67.6K | 8,426,995 | SEC↗ |
| BVF INC/IL | 10% Owner | P Buy | 2018-11-19 | 2018-11-21 | 733,151 | $1.37 | $1.00M | 8,376,951 | SEC↗ |
| BVF INC/IL | 10% Owner | P Buy | 2018-11-19 | 2018-11-21 | 5,573 | $1.35 | $7.5K | 1,254,412 | SEC↗ |
| BVF INC/IL | 10% Owner | P Buy | 2018-11-19 | 2018-11-21 | 38,001 | $1.35 | $51.3K | 6,410,597 | SEC↗ |
| BVF INC/IL | 10% Owner | P Buy | 2018-11-19 | 2018-11-21 | 81,648 | $1.37 | $111.9K | 1,248,839 | SEC↗ |
| BVF INC/IL | 10% Owner | P Buy | 2018-11-19 | 2018-11-21 | 556,709 | $1.37 | $762.7K | 6,372,596 | SEC↗ |
| BVF Partners OS Ltd. | Other | P Buy | 2018-11-15 | 2018-11-15 | 39,074 | $1.35 | $52.7K | 5,815,887 | SEC↗ |
| BVF Partners OS Ltd. | Other | P Buy | 2018-11-15 | 2018-11-15 | 52,400 | $1.35 | $70.7K | 7,643,800 | SEC↗ |
| BVF Partners OS Ltd. | Other | P Buy | 2018-11-14 | 2018-11-15 | 92,960 | $1.34 | $124.6K | 5,776,813 | SEC↗ |
| BVF Partners OS Ltd. | Other | P Buy | 2018-11-14 | 2018-11-15 | 117,290 | $1.34 | $157.2K | 7,591,400 | SEC↗ |
| BVF Partners OS Ltd. | Other | P Buy | 2018-11-13 | 2018-11-15 | 41,454 | $1.35 | $56.0K | 7,474,110 | SEC↗ |
| BVF Partners OS Ltd. | Other | P Buy | 2018-11-13 | 2018-11-15 | 562,754 | $1.35 | $759.7K | 5,683,853 | SEC↗ |
| Perkins Adelene Q | Chief Executive Officer | S Sale | 2018-10-01 | 2018-10-02 | 5,000 | $2.82 | $14.1K | 609,561 | SEC↗ |
| Kutok Jeffery | Chief Scientific Officer | S Sale | 2018-08-16 | 2018-08-17 | 6,133 | $2.00 | $12.3K | 0 | SEC↗ |
| Kutok Jeffery | Chief Scientific Officer | S Sale | 2018-08-15 | 2018-08-17 | 8,180 | $2.01 | $16.4K | 6,133 | SEC↗ |
| Agresta Samuel | Chief Medical Officer | A Award deriv | 2018-08-06 | 2018-08-07 | 300,000 | — | $0 | 300,000 | SEC↗ |
| Kutok Jeffery | Chief Scientific Officer | S Sale | 2018-06-22 | 2018-06-25 | 14,313 | $2.00 | $28.6K | 14,313 | SEC↗ |
| BVF PARTNERS L P/IL | 10% Owner | P Buy | 2018-06-21 | 2018-06-21 | 230,555 | $1.65 | $380.4K | 7,432,656 | SEC↗ |
| BVF PARTNERS L P/IL | 10% Owner | P Buy | 2018-06-21 | 2018-06-21 | 158,151 | $1.65 | $260.9K | 5,121,099 | SEC↗ |
| BVF PARTNERS L P/IL | 10% Owner | P Buy | 2018-06-21 | 2018-06-21 | 36,825 | $1.65 | $60.8K | 1,167,191 | SEC↗ |
| BVF PARTNERS L P/IL | 10% Owner | P Buy | 2018-06-19 | 2018-06-21 | 1,916,760 | $1.65 | $3.16M | 7,202,101 | SEC↗ |
| BVF PARTNERS L P/IL | 10% Owner | P Buy | 2018-06-19 | 2018-06-21 | 1,419,907 | $1.65 | $2.34M | 4,962,948 | SEC↗ |
| BVF PARTNERS L P/IL | 10% Owner | P Buy | 2018-06-19 | 2018-06-21 | 179,893 | $1.65 | $296.8K | 1,130,366 | SEC↗ |
| VENUTI MICHAEL C | Director | A Award deriv | 2018-06-12 | 2018-06-14 | 20,000 | — | $0 | 20,000 | SEC↗ |
| VENUTI MICHAEL C | Director | A Award deriv | 2018-06-12 | 2018-06-14 | 4,000 | — | $0 | 4,000 | SEC↗ |
| Kauffman Michael | Director | A Award deriv | 2018-06-12 | 2018-06-14 | 20,000 | — | $0 | 20,000 | SEC↗ |
| EVNIN ANTHONY B | Director | A Award deriv | 2018-06-12 | 2018-06-14 | 20,000 | — | $0 | 20,000 | SEC↗ |
| EVNIN ANTHONY B | Director | A Award deriv | 2018-06-12 | 2018-06-14 | 2,000 | — | $0 | 2,000 | SEC↗ |
| SMITH IAN F | Director | A Award deriv | 2018-06-12 | 2018-06-14 | 20,000 | — | $0 | 20,000 | SEC↗ |
| SMITH IAN F | Director | A Award deriv | 2018-06-12 | 2018-06-14 | 4,000 | — | $0 | 4,000 | SEC↗ |
| Berkowitz Jeffrey | Director | A Award deriv | 2018-06-12 | 2018-06-14 | 20,000 | — | $0 | 20,000 | SEC↗ |
| SELBY NORMAN C | Director | A Award deriv | 2018-06-12 | 2018-06-14 | 20,000 | — | $0 | 20,000 | SEC↗ |
| SELBY NORMAN C | Director | A Award deriv | 2018-06-12 | 2018-06-14 | 2,000 | — | $0 | 2,000 | SEC↗ |
| SELBY NORMAN C | Director | A Award deriv | 2018-06-12 | 2018-06-14 | 10,000 | — | $0 | 10,000 | SEC↗ |
| BEIER DAVID W | Director | A Award | 2018-06-12 | 2018-06-14 | 5,714 | $1.75 | $10.0K | 5,714 | SEC↗ |
| EVNIN ANTHONY B | Director | A Award | 2018-06-12 | 2018-06-14 | 11,428 | $1.75 | $20.0K | 130,013 | SEC↗ |
| SMITH IAN F | Director | A Award | 2018-06-12 | 2018-06-14 | 22,857 | $1.75 | $40.0K | 45,845 | SEC↗ |
| Berkowitz Jeffrey | Director | A Award | 2018-06-12 | 2018-06-14 | 22,857 | $1.75 | $40.0K | 58,988 | SEC↗ |
| BVF Partners OS Ltd. | Other | P Buy | 2018-04-10 | 2018-04-11 | 546,865 | $2.00 | $1.09M | 5,285,341 | SEC↗ |
| BVF Partners OS Ltd. | Other | P Buy | 2018-04-10 | 2018-04-11 | 97,453 | $2.00 | $194.9K | 950,473 | SEC↗ |
| BVF Partners OS Ltd. | Other | P Buy | 2018-04-10 | 2018-04-11 | 365,682 | $2.00 | $731.4K | 3,543,041 | SEC↗ |
| BVF Partners OS Ltd. | Other | P Buy | 2018-04-09 | 2018-04-11 | 62,437 | $1.90 | $118.6K | 853,020 | SEC↗ |
| BVF Partners OS Ltd. | Other | P Buy | 2018-04-09 | 2018-04-11 | 208,872 | $1.90 | $396.9K | 3,177,359 | SEC↗ |
| BVF Partners OS Ltd. | Other | P Buy | 2018-04-09 | 2018-04-11 | 228,691 | $1.90 | $434.5K | 4,738,476 | SEC↗ |
| BEIER DAVID W | Director | A Award deriv | 2018-04-01 | 2018-04-02 | 40,000 | — | $0 | 40,000 | SEC↗ |
| Perkins Adelene Q | Chief Executive Officer | S Sale | 2018-03-05 | 2018-03-07 | 5,000 | $2.78 | $13.9K | 607,252 | SEC↗ |
| Perkins Adelene Q | Chief Executive Officer | A Award deriv | 2018-01-08 | 2018-01-09 | 500,000 | — | $0 | 500,000 | SEC↗ |
| BLOCH LAWRENCE E | President | A Award deriv | 2018-01-02 | 2018-01-04 | 100,000 | — | $0 | 100,000 | SEC↗ |
| Kutok Jeffery | Chief Scientific Officer | A Award deriv | 2018-01-02 | 2018-01-04 | 70,000 | — | $0 | 70,000 | SEC↗ |
| Perkins Adelene Q | Chief Executive Officer | A Award deriv | 2018-01-02 | 2018-01-04 | 180,000 | — | $0 | 180,000 | SEC↗ |
| Tasker Seth A | General Counsel | A Award deriv | 2018-01-02 | 2018-01-04 | 65,000 | — | $0 | 65,000 | SEC↗ |
| BLOCH LAWRENCE E | President | A Award | 2018-01-02 | 2018-01-04 | 37,881 | — | $0 | 626,133 | SEC↗ |
| Kutok Jeffery | Chief Scientific Officer | A Award | 2018-01-02 | 2018-01-04 | 28,626 | — | $0 | 28,626 | SEC↗ |
| Perkins Adelene Q | Chief Executive Officer | A Award | 2018-01-02 | 2018-01-04 | 69,924 | — | $0 | 612,252 | SEC↗ |
| Tasker Seth A | General Counsel | A Award | 2018-01-02 | 2018-01-04 | 22,351 | — | $0 | 41,284 | SEC↗ |
| BLOCH LAWRENCE E | President | P Buy | 2017-12-06 | 2017-12-07 | 500,000 | $1.81 | $905.0K | 580,944 | SEC↗ |
| Biotechnology Value Trading Fu | Other | P Buy | 2017-10-04 | 2017-10-05 | 63,042 | $1.28 | $80.7K | 790,583 | SEC↗ |
| Biotechnology Value Trading Fu | Other | P Buy | 2017-10-04 | 2017-10-05 | 235,326 | $1.28 | $301.2K | 2,968,487 | SEC↗ |
| Biotechnology Value Trading Fu | Other | P Buy | 2017-10-04 | 2017-10-05 | 355,081 | $1.28 | $454.5K | 4,509,785 | SEC↗ |
| Biotechnology Value Trading Fu | Other | P Buy | 2017-10-03 | 2017-10-05 | 28,918 | $1.24 | $35.9K | 727,541 | SEC↗ |
| Biotechnology Value Trading Fu | Other | P Buy | 2017-10-03 | 2017-10-05 | 394,078 | $1.24 | $488.7K | 2,733,161 | SEC↗ |
| Biotechnology Value Trading Fu | Other | P Buy | 2017-10-03 | 2017-10-05 | 523,601 | $1.24 | $649.3K | 4,154,704 | SEC↗ |
| Tasker Seth A | General Counsel | A Award | 2017-07-21 | 2017-07-24 | 8,916 | — | $0 | 17,833 | SEC↗ |
| BLOCH LAWRENCE E | President | A Award | 2017-07-21 | 2017-07-24 | 39,039 | — | $0 | 80,944 | SEC↗ |
| Perkins Adelene Q | Chief Executive Officer | A Award | 2017-07-21 | 2017-07-24 | 85,800 | — | $0 | 535,020 | SEC↗ |
| Tasker Seth A | General Counsel | A Award deriv | 2017-05-25 | 2017-05-26 | 150,000 | — | $0 | 150,000 | SEC↗ |
| VENUTI MICHAEL C | Director | A Award deriv | 2017-05-25 | 2017-05-26 | 4,000 | — | $0 | 4,000 | SEC↗ |
| VENUTI MICHAEL C | Director | A Award deriv | 2017-05-25 | 2017-05-26 | 20,000 | — | $0 | 20,000 | SEC↗ |
| Kutok Jeffery | Chief Scientific Officer | A Award deriv | 2017-05-25 | 2017-05-26 | 125,000 | — | $0 | 125,000 | SEC↗ |
| SMITH IAN F | Director | A Award deriv | 2017-05-25 | 2017-05-26 | 20,000 | — | $0 | 20,000 | SEC↗ |
| SMITH IAN F | Director | A Award deriv | 2017-05-25 | 2017-05-26 | 4,000 | — | $0 | 4,000 | SEC↗ |
| EVNIN ANTHONY B | Director | A Award deriv | 2017-05-25 | 2017-05-26 | 2,000 | — | $0 | 2,000 | SEC↗ |
| EVNIN ANTHONY B | Director | A Award deriv | 2017-05-25 | 2017-05-26 | 20,000 | — | $0 | 20,000 | SEC↗ |
| Berkowitz Jeffrey | Director | A Award deriv | 2017-05-25 | 2017-05-26 | 20,000 | — | $0 | 20,000 | SEC↗ |
| BLOCH LAWRENCE E | President | A Award deriv | 2017-05-25 | 2017-05-26 | 250,000 | — | $0 | 250,000 | SEC↗ |
| SELBY NORMAN C | Director | A Award deriv | 2017-05-25 | 2017-05-26 | 20,000 | — | $0 | 20,000 | SEC↗ |
| SELBY NORMAN C | Director | A Award deriv | 2017-05-25 | 2017-05-26 | 10,000 | — | $0 | 10,000 | SEC↗ |
| SELBY NORMAN C | Director | A Award deriv | 2017-05-25 | 2017-05-26 | 2,000 | — | $0 | 2,000 | SEC↗ |
| SMITH IAN F | Director | A Award | 2017-05-25 | 2017-05-26 | 22,988 | $1.74 | $40.0K | 22,988 | SEC↗ |
| EVNIN ANTHONY B | Director | A Award | 2017-05-25 | 2017-05-26 | 11,494 | $1.74 | $20.0K | 118,585 | SEC↗ |
| Berkowitz Jeffrey | Director | A Award | 2017-05-25 | 2017-05-26 | 5,747 | $1.74 | $10.0K | 36,131 | SEC↗ |
| Kauffman Michael | Director | A Award deriv | 2017-04-05 | 2017-04-06 | 40,000 | — | $0 | 40,000 | SEC↗ |
| VENUTI MICHAEL C | Director | S Sale | 2017-03-17 | 2017-03-20 | 6,250 | $3.48 | $21.8K | 50,000 | SEC↗ |
| Kutok Jeffery | Chief Scientific Officer | A Award deriv | 2017-02-10 | 2017-02-14 | 250,000 | — | $0 | 250,000 | SEC↗ |
| Berkowitz Jeffrey | Director | A Award deriv | 2017-01-06 | 2017-01-09 | 40,000 | — | $0 | 40,000 | SEC↗ |
| Tasker Seth A | General Counsel | A Award deriv | 2017-01-06 | 2017-01-09 | 250,000 | — | $0 | 250,000 | SEC↗ |
| BLOCH LAWRENCE E | President | A Award deriv | 2017-01-06 | 2017-01-09 | 500,000 | — | $0 | 500,000 | SEC↗ |
| Baselga Jose | Director | A Award deriv | 2017-01-06 | 2017-01-09 | 40,000 | — | $0 | 40,000 | SEC↗ |
| Perkins Adelene Q | Chief Executive Officer | A Award deriv | 2017-01-06 | 2017-01-09 | 1,000,000 | — | $0 | 1,000,000 | SEC↗ |
| SELBY NORMAN C | Director | A Award deriv | 2017-01-06 | 2017-01-09 | 40,000 | — | $0 | 40,000 | SEC↗ |
| SMITH IAN F | Director | A Award deriv | 2017-01-06 | 2017-01-09 | 40,000 | — | $0 | 40,000 | SEC↗ |
| EVNIN ANTHONY B | Director | A Award deriv | 2017-01-06 | 2017-01-09 | 40,000 | — | $0 | 40,000 | SEC↗ |
| VENUTI MICHAEL C | Director | A Award deriv | 2017-01-06 | 2017-01-09 | 40,000 | — | $0 | 40,000 | SEC↗ |
| BVF PARTNERS L P/IL | 10% Owner | P Buy | 2017-01-03 | 2017-01-05 | 1,145 | $1.34 | $1.5K | 3,631,103 | SEC↗ |
| BVF PARTNERS L P/IL | 10% Owner | P Buy | 2017-01-03 | 2017-01-05 | 3,234 | $1.34 | $4.3K | 2,339,083 | SEC↗ |
| BIOTECHNOLOGY VALUE FUND II LP | 10% Owner | P Buy | 2016-12-30 | 2016-12-30 | 2,348 | $1.34 | $3.1K | 3,629,958 | SEC↗ |
| BIOTECHNOLOGY VALUE FUND II LP | 10% Owner | P Buy | 2016-12-30 | 2016-12-30 | 1,205 | $1.34 | $1.6K | 2,335,849 | SEC↗ |
| BIOTECHNOLOGY VALUE FUND II LP | 10% Owner | P Buy | 2016-12-28 | 2016-12-30 | 260,046 | $1.34 | $348.5K | 2,334,644 | SEC↗ |
| BIOTECHNOLOGY VALUE FUND II LP | 10% Owner | P Buy | 2016-12-28 | 2016-12-30 | 77,076 | $1.34 | $103.3K | 698,623 | SEC↗ |
| BIOTECHNOLOGY VALUE FUND II LP | 10% Owner | P Buy | 2016-12-28 | 2016-12-30 | 401,726 | $1.34 | $538.3K | 3,627,610 | SEC↗ |
| BVF INC/IL | 10% Owner | P Buy | 2016-12-20 | 2016-12-20 | 11,646 | $1.35 | $15.7K | 3,225,884 | SEC↗ |
| BVF INC/IL | 10% Owner | P Buy | 2016-12-20 | 2016-12-20 | 2,244 | $1.35 | $3.0K | 621,547 | SEC↗ |
| BVF INC/IL | 10% Owner | P Buy | 2016-12-20 | 2016-12-20 | 8,111 | $1.35 | $10.9K | 2,074,598 | SEC↗ |
| BVF INC/IL | 10% Owner | P Buy | 2016-12-19 | 2016-12-20 | 21,021 | $1.36 | $28.6K | 619,303 | SEC↗ |
| BVF INC/IL | 10% Owner | P Buy | 2016-12-19 | 2016-12-20 | 69,041 | $1.36 | $93.9K | 2,066,487 | SEC↗ |
| BVF INC/IL | 10% Owner | P Buy | 2016-12-19 | 2016-12-20 | 108,202 | $1.36 | $147.2K | 3,214,238 | SEC↗ |
| BVF INC/IL | 10% Owner | P Buy | 2016-12-16 | 2016-12-20 | 236,393 | $1.28 | $302.6K | 3,106,036 | SEC↗ |
| BVF INC/IL | 10% Owner | P Buy | 2016-12-16 | 2016-12-20 | 47,812 | $1.28 | $61.2K | 598,282 | SEC↗ |
| BVF INC/IL | 10% Owner | P Buy | 2016-12-16 | 2016-12-20 | 150,451 | $1.28 | $192.6K | 1,997,446 | SEC↗ |
| KANGO SUJAY | Chief Commercial Officer | S Sale | 2016-12-13 | 2016-12-14 | 7,676 | $1.25 | $9.6K | 599 | SEC↗ |
| KANGO SUJAY | Chief Commercial Officer | S Sale | 2016-12-13 | 2016-12-14 | 298 | $1.30 | $387 | 50,292 | SEC↗ |
| KANGO SUJAY | Chief Commercial Officer | S Sale | 2016-12-13 | 2016-12-14 | 42,017 | $1.27 | $53.4K | 8,275 | SEC↗ |
| KANGO SUJAY | Chief Commercial Officer | S Sale | 2016-12-12 | 2016-12-14 | 25,009 | $1.30 | $32.5K | 50,590 | SEC↗ |
| BIOTECHNOLOGY VALUE FUND II LP | 10% Owner | P Buy | 2016-12-02 | 2016-12-02 | 18,586 | $1.19 | $22.1K | 1,846,995 | SEC↗ |
| BIOTECHNOLOGY VALUE FUND II LP | 10% Owner | P Buy | 2016-12-02 | 2016-12-02 | 2,916 | $1.19 | $3.5K | 550,470 | SEC↗ |
| BIOTECHNOLOGY VALUE FUND II LP | 10% Owner | P Buy | 2016-12-02 | 2016-12-02 | 30,998 | $1.19 | $36.9K | 2,869,643 | SEC↗ |
| BIOTECHNOLOGY VALUE FUND II LP | 10% Owner | P Buy | 2016-12-01 | 2016-12-02 | 81,276 | $1.18 | $95.9K | 2,838,645 | SEC↗ |
| BIOTECHNOLOGY VALUE FUND II LP | 10% Owner | P Buy | 2016-12-01 | 2016-12-02 | 15,161 | $1.18 | $17.9K | 547,554 | SEC↗ |
| BIOTECHNOLOGY VALUE FUND II LP | 10% Owner | P Buy | 2016-12-01 | 2016-12-02 | 52,457 | $1.18 | $61.9K | 1,828,409 | SEC↗ |
| Perkins Adelene Q | Chief Executive Officer | A Award | 2016-10-31 | 2017-04-14 | 85,800 | — | $0 | 449,220 | SEC↗ |
| Perkins Adelene Q | President & CEO | A Award | 2016-10-31 | 2016-11-02 | 85,800 | — | $0 | 447,411 | SEC↗ |
| ADAMS JULIAN | President of R&D | A Award | 2016-10-31 | 2016-11-02 | 59,150 | — | $0 | 59,150 | SEC↗ |
| KANGO SUJAY | Chief Commercial Officer | A Award | 2016-10-31 | 2016-11-02 | 75,000 | — | $0 | 75,599 | SEC↗ |
| BLOCH LAWRENCE E | EVP, CFO & CBO | A Award | 2016-10-31 | 2016-11-02 | 39,039 | — | $0 | 41,905 | SEC↗ |
| Tasker Seth A | General Counsel | A Award | 2016-10-31 | 2016-11-02 | 8,917 | — | $0 | 8,917 | SEC↗ |
| Berkowitz Jeffrey | Director | A Award deriv | 2016-06-17 | 2016-06-21 | 20,000 | — | $0 | 20,000 | SEC↗ |
| LANDER ERIC S | Director | A Award deriv | 2016-06-17 | 2016-06-21 | 20,000 | — | $0 | 20,000 | SEC↗ |
| VENUTI MICHAEL C | Director | A Award deriv | 2016-06-17 | 2016-06-21 | 4,000 | — | $0 | 4,000 | SEC↗ |
| VENUTI MICHAEL C | Director | A Award deriv | 2016-06-17 | 2016-06-21 | 20,000 | — | $0 | 20,000 | SEC↗ |
| EVNIN ANTHONY B | Director | A Award deriv | 2016-06-17 | 2016-06-21 | 2,000 | — | $0 | 2,000 | SEC↗ |
| EVNIN ANTHONY B | Director | A Award deriv | 2016-06-17 | 2016-06-21 | 20,000 | — | $0 | 20,000 | SEC↗ |
| SMITH IAN F | Director | A Award deriv | 2016-06-17 | 2016-06-21 | 4,000 | — | $0 | 4,000 | SEC↗ |
| SMITH IAN F | Director | A Award deriv | 2016-06-17 | 2016-06-21 | 20,000 | — | $0 | 20,000 | SEC↗ |
| SELBY NORMAN C | Director | A Award deriv | 2016-06-17 | 2016-06-21 | 10,000 | — | $0 | 10,000 | SEC↗ |
| SELBY NORMAN C | Director | A Award deriv | 2016-06-17 | 2016-06-21 | 20,000 | — | $0 | 20,000 | SEC↗ |
| SELBY NORMAN C | Director | A Award deriv | 2016-06-17 | 2016-06-21 | 2,000 | — | $0 | 2,000 | SEC↗ |
| Baselga Jose | Director | A Award deriv | 2016-06-17 | 2016-06-21 | 20,000 | — | $0 | 20,000 | SEC↗ |
| Berkowitz Jeffrey | Director | A Award | 2016-06-17 | 2016-06-21 | 26,315 | $1.52 | $40.0K | 30,384 | SEC↗ |
| LANDER ERIC S | Director | A Award | 2016-06-17 | 2016-06-21 | 6,578 | $1.52 | $10.0K | 80,319 | SEC↗ |
| EVNIN ANTHONY B | Director | A Award | 2016-06-17 | 2016-06-21 | 13,157 | $1.52 | $20.0K | 107,091 | SEC↗ |
| Lindblom Christopher M | Principal Accounting Officer | A Award deriv | 2016-05-02 | 2016-05-04 | 40,000 | — | $0 | 40,000 | SEC↗ |
| Perkins Adelene Q | President & CEO | A Award deriv | 2016-01-06 | 2016-01-08 | 185,000 | — | $0 | 185,000 | SEC↗ |
| ADAMS JULIAN | President of R&D | A Award deriv | 2016-01-06 | 2016-01-08 | 80,000 | — | $0 | 80,000 | SEC↗ |
| KANGO SUJAY | Chief Commercial Officer | A Award deriv | 2016-01-06 | 2016-01-08 | 60,000 | — | $0 | 60,000 | SEC↗ |
| BLOCH LAWRENCE E | EVP, CFO & CBO | A Award deriv | 2016-01-06 | 2016-01-08 | 70,000 | — | $0 | 70,000 | SEC↗ |
| Bertrand William C JR | General Counsel | A Award deriv | 2015-10-19 | 2015-10-21 | 200,000 | — | $0 | 200,000 | SEC↗ |
| Berkowitz Jeffrey | Director | A Award | 2015-09-01 | 2015-09-03 | 4,069 | $8.60 | $35.0K | 4,069 | SEC↗ |
| EVNIN ANTHONY B | Director | A Award | 2015-09-01 | 2015-09-03 | 2,034 | $8.60 | $17.5K | 93,934 | SEC↗ |
| LANDER ERIC S | Director | A Award | 2015-09-01 | 2015-09-03 | 2,034 | $8.60 | $17.5K | 73,741 | SEC↗ |
| Perkins Adelene Q | President & CEO | S Sale | 2015-06-25 | 2015-06-26 | 5,000 | $10.93 | $54.6K | 359,432 | SEC↗ |
| VENUTI MICHAEL C | Director | A Award deriv | 2015-06-15 | 2015-06-16 | 15,000 | — | $0 | 15,000 | SEC↗ |
| VENUTI MICHAEL C | Director | A Award deriv | 2015-06-15 | 2015-06-16 | 4,000 | — | $0 | 4,000 | SEC↗ |
| EVNIN ANTHONY B | Director | A Award deriv | 2015-06-15 | 2015-06-16 | 15,000 | — | $0 | 15,000 | SEC↗ |
| EVNIN ANTHONY B | Director | A Award deriv | 2015-06-15 | 2015-06-16 | 2,000 | — | $0 | 2,000 | SEC↗ |
| Berkowitz Jeffrey | Director | A Award deriv | 2015-06-15 | 2015-06-16 | 15,000 | — | $0 | 15,000 | SEC↗ |
| LANDER ERIC S | Director | A Award deriv | 2015-06-15 | 2015-06-16 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Fyfe Gwen A. | Director | A Award deriv | 2015-06-15 | 2015-06-16 | 15,000 | — | $0 | 15,000 | SEC↗ |
| SMITH IAN F | Director | A Award deriv | 2015-06-15 | 2015-06-16 | 4,000 | — | $0 | 4,000 | SEC↗ |
| SMITH IAN F | Director | A Award deriv | 2015-06-15 | 2015-06-16 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Baselga Jose | Director | A Award deriv | 2015-06-15 | 2015-06-16 | 15,000 | — | $0 | 15,000 | SEC↗ |
| SELBY NORMAN C | Director | A Award deriv | 2015-06-15 | 2015-06-16 | 15,000 | — | $0 | 15,000 | SEC↗ |
| SELBY NORMAN C | Director | A Award deriv | 2015-06-15 | 2015-06-16 | 2,000 | — | $0 | 2,000 | SEC↗ |
| SELBY NORMAN C | Director | A Award deriv | 2015-06-15 | 2015-06-16 | 10,000 | — | $0 | 10,000 | SEC↗ |
| Palombella Vito J. | Chief Scientific Officer | S Sale | 2015-06-15 | 2015-06-16 | 4,737 | $10.97 | $52.0K | 868 | SEC↗ |
| Perkins Adelene Q | President & CEO | S Sale | 2015-05-27 | 2015-05-28 | 10,000 | $12.81 | $128.1K | 364,432 | SEC↗ |
| Perkins Adelene Q | President & CEO | S Sale | 2015-05-14 | 2015-05-15 | 10,000 | $12.18 | $121.8K | 374,432 | SEC↗ |
| Palombella Vito J. | Chief Scientific Officer | M Exercise deriv | 2015-04-30 | 2015-05-01 | 4,737 | — | $0 | 0 | SEC↗ |
| Palombella Vito J. | Chief Scientific Officer | M Exercise | 2015-04-30 | 2015-05-01 | 4,737 | $2.04 | $9.7K | 5,605 | SEC↗ |
| Lam Winston K.C. | General Counsel | A Award deriv | 2015-04-15 | 2015-04-15 | 200,000 | — | $0 | 200,000 | SEC↗ |
| KANGO SUJAY | Chief Commercial Officer | A Award deriv | 2015-03-31 | 2015-04-01 | 200,000 | — | $0 | 200,000 | SEC↗ |
| Perkins Adelene Q | President & CEO | S Sale | 2015-03-16 | 2015-03-17 | 20,000 | $16.00 | $320.0K | 384,432 | SEC↗ |
| Perkins Adelene Q | President & CEO | S Sale | 2015-03-05 | 2015-03-09 | 25,000 | $16.50 | $412.5K | 404,432 | SEC↗ |
| Perkins Adelene Q | President & CEO | S Sale | 2015-01-29 | 2015-02-02 | 20,000 | $14.83 | $296.6K | 427,535 | SEC↗ |
| Perkins Adelene Q | President & CEO | S Sale | 2015-01-29 | 2015-03-09 | 20,000 | $14.83 | $296.6K | 429,432 | SEC↗ |
| Roth David | Chief Medical Officer | A Award deriv | 2015-01-14 | 2015-01-16 | 85,000 | — | $0 | 85,000 | SEC↗ |
| ADAMS JULIAN | President of R&D | A Award deriv | 2015-01-14 | 2015-01-16 | 125,000 | — | $0 | 125,000 | SEC↗ |
| Palombella Vito J. | Chief Scientific Officer | A Award deriv | 2015-01-14 | 2015-01-16 | 85,000 | — | $0 | 85,000 | SEC↗ |
| BLOCH LAWRENCE E | EVP, CFO & CBO | A Award deriv | 2015-01-14 | 2015-01-16 | 125,000 | — | $0 | 125,000 | SEC↗ |
| Perkins Adelene Q | President & CEO | A Award deriv | 2015-01-14 | 2015-01-16 | 250,000 | — | $0 | 250,000 | SEC↗ |
| Palombella Vito J. | Chief Scientific Officer | M Exercise deriv | 2014-12-15 | 2014-12-16 | 4,737 | — | $0 | 0 | SEC↗ |
| Palombella Vito J. | Chief Scientific Officer | S Sale | 2014-12-15 | 2014-12-16 | 4,737 | $16.32 | $77.3K | 0 | SEC↗ |
| Palombella Vito J. | Chief Scientific Officer | M Exercise | 2014-12-15 | 2014-12-16 | 4,737 | $2.04 | $9.7K | 4,737 | SEC↗ |
| Palombella Vito J. | Chief Scientific Officer | M Exercise deriv | 2014-11-26 | 2014-11-28 | 4,736 | — | $0 | 0 | SEC↗ |
| Palombella Vito J. | Chief Scientific Officer | M Exercise | 2014-11-26 | 2014-11-28 | 4,736 | $2.04 | $9.7K | 4,736 | SEC↗ |
| Palombella Vito J. | Chief Scientific Officer | S Sale | 2014-11-26 | 2014-11-28 | 4,736 | $15.00 | $71.0K | 0 | SEC↗ |
| EVNIN ANTHONY B | Director | M Exercise deriv | 2014-10-03 | 2014-10-06 | 7,500 | — | $0 | 7,500 | SEC↗ |
| EVNIN ANTHONY B | Director | M Exercise deriv | 2014-10-03 | 2014-10-06 | 10,000 | — | $0 | 0 | SEC↗ |
| EVNIN ANTHONY B | Director | M Exercise deriv | 2014-10-03 | 2014-10-06 | 6,000 | — | $0 | 0 | SEC↗ |
| EVNIN ANTHONY B | Director | M Exercise deriv | 2014-10-03 | 2014-10-06 | 1,000 | — | $0 | 1,000 | SEC↗ |
| EVNIN ANTHONY B | Director | M Exercise | 2014-10-03 | 2014-10-06 | 10,000 | $12.94 | $129.4K | 83,400 | SEC↗ |
| EVNIN ANTHONY B | Director | M Exercise | 2014-10-03 | 2014-10-06 | 7,500 | $11.85 | $88.9K | 90,900 | SEC↗ |
| EVNIN ANTHONY B | Director | M Exercise | 2014-10-03 | 2014-10-06 | 1,000 | $11.85 | $11.8K | 91,900 | SEC↗ |
| EVNIN ANTHONY B | Director | M Exercise | 2014-10-03 | 2014-10-06 | 6,000 | $12.94 | $77.6K | 73,400 | SEC↗ |
| EVNIN ANTHONY B | Director | S Sale | 2014-09-30 | 2014-10-02 | 112,451 | $13.56 | $1.52M | 0 | SEC↗ |
| Palombella Vito J. | Chief Scientific Officer | M Exercise deriv | 2014-09-03 | 2014-09-05 | 7,105 | — | $0 | 0 | SEC↗ |
| Palombella Vito J. | Chief Scientific Officer | M Exercise deriv | 2014-09-03 | 2014-09-05 | 2,367 | — | $0 | 0 | SEC↗ |
| Palombella Vito J. | Chief Scientific Officer | S Sale | 2014-09-03 | 2014-09-05 | 9,472 | $15.39 | $145.8K | 0 | SEC↗ |
| Palombella Vito J. | Chief Scientific Officer | M Exercise | 2014-09-03 | 2014-09-05 | 7,105 | $2.04 | $14.5K | 7,105 | SEC↗ |
| Palombella Vito J. | Chief Scientific Officer | M Exercise | 2014-09-03 | 2014-09-05 | 2,367 | $2.04 | $4.8K | 9,472 | SEC↗ |
| Palombella Vito J. | Chief Scientific Officer | S Sale | 2014-07-01 | 2014-07-02 | 879 | $12.87 | $11.3K | 0 | SEC↗ |
| Palombella Vito J. | Chief Scientific Officer | A Award | 2014-06-30 | 2014-07-02 | 879 | $10.83 | $9.5K | 879 | SEC↗ |
| SMITH IAN F | Director | A Award deriv | 2014-06-17 | 2014-06-19 | 15,000 | — | $0 | 15,000 | SEC↗ |
| SMITH IAN F | Director | A Award deriv | 2014-06-17 | 2014-06-19 | 4,000 | — | $0 | 4,000 | SEC↗ |
| SELBY NORMAN C | Director | A Award deriv | 2014-06-17 | 2014-06-19 | 15,000 | — | $0 | 15,000 | SEC↗ |
| SELBY NORMAN C | Director | A Award deriv | 2014-06-17 | 2014-06-19 | 10,000 | — | $0 | 10,000 | SEC↗ |
| SELBY NORMAN C | Director | A Award deriv | 2014-06-17 | 2014-06-19 | 2,000 | — | $0 | 2,000 | SEC↗ |
| LANDER ERIC S | Director | A Award deriv | 2014-06-17 | 2014-06-19 | 15,000 | — | $0 | 15,000 | SEC↗ |
| VENUTI MICHAEL C | Director | A Award deriv | 2014-06-17 | 2014-06-19 | 15,000 | — | $0 | 15,000 | SEC↗ |
| VENUTI MICHAEL C | Director | A Award deriv | 2014-06-17 | 2014-06-19 | 4,000 | — | $0 | 4,000 | SEC↗ |
| Fyfe Gwen A. | Director | A Award deriv | 2014-06-17 | 2014-06-19 | 15,000 | — | $0 | 15,000 | SEC↗ |
| EVNIN ANTHONY B | Director | A Award deriv | 2014-06-17 | 2014-06-19 | 15,000 | — | $0 | 15,000 | SEC↗ |
| EVNIN ANTHONY B | Director | A Award deriv | 2014-06-17 | 2014-06-19 | 2,000 | — | $0 | 2,000 | SEC↗ |
| Baselga Jose | Director | A Award deriv | 2014-03-06 | 2014-03-10 | 30,000 | — | $0 | 30,000 | SEC↗ |
| SELBY NORMAN C | Director | M Exercise deriv | 2014-03-06 | 2014-03-10 | 2,500 | — | $0 | 2,500 | SEC↗ |
| Berkowitz Jeffrey | Director | A Award deriv | 2014-03-06 | 2014-03-10 | 30,000 | — | $0 | 30,000 | SEC↗ |
| SELBY NORMAN C | Director | M Exercise | 2014-03-06 | 2014-03-10 | 2,500 | $8.87 | $22.2K | 10,000 | SEC↗ |
| Palombella Vito J. | Chief Scientific Officer | M Exercise deriv | 2014-02-25 | 2014-02-27 | 4,736 | — | $0 | 0 | SEC↗ |
| Palombella Vito J. | Chief Scientific Officer | M Exercise | 2014-02-25 | 2014-02-27 | 4,736 | $2.04 | $9.7K | 4,736 | SEC↗ |