IONS

IONIS PHARMACEUTICALS INCCIK 874015 ☆ Sign in to watch Congress trades

Open-mkt buys · 90d

—

0 trades · 0 insiders

Open-mkt sales · 90d

$61.4K

2 trades · 2 insiders

Net · 90d

$-61.4K

Insiders on file

AI insights for IONS PRO

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AI insights for IONS

Insider sentiment score with a plain-English explanation, conviction score on every buy, and how the stock performed 30 and 90 days after past insider buys.

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Daily buy vs sell · 90 days

■ Open-market buys (P) ■ Open-market sales (S) · daily dollar value by transaction date

Insiders

Insider	Role	Trades	Bought	Sold	Last trade
Devers Shannon L.	EVP, Chief Human Resourses Ofc	61	$0	$9.05M	2026-10-16
Swayze Eric	SVP, Research	116	$0	$11.17M	2026-10-16
Birchler Brian	Vice President Level 14	49	$0	$4.04M	2026-08-31
O'NEIL PATRICK R.	SVP, Legal and General Counsel	290	$0	$30.98M	2026-08-31
Monia Brett P	SVP, Antisense Drug Discovery	214	$0	$60.65M	2026-08-31
BENNETT C FRANK	SVP, Antisense Research	198	$0	$31.71M	2026-08-31
Hayden Michael R	Director	49	$2.78M	$0	2026-07-31
Reikes Peter N	Director	22	$0	$0	2026-07-15
HANTSON LUDWIG	Director	2	$0	$0	2026-07-15
HERMAN JOAN E	Director	52	$0	$3.17M	2026-07-15
BERTHELSEN SPENCER R	Director	105	$0	$4.88M	2026-07-15
Kordasiewicz Holly B.	EVP, Chief Development Officer	18	$0	$4.81M	2026-07-07
Diaz Allene M.	Director	36	$0	$5.39M	2026-07-07
YANG MICHAEL J.	Director	14	$0	$0	2026-07-01
LOSCALZO JOSEPH	Director	100	$0	$8.56M	2026-07-01
KLEIN JOSEPH III	Director	180	$0	$12.96M	2026-07-01
Schneider Eugene	EVP, Chf Clinical Develop Offc	65	$0	$8.05M	2026-06-26
Baroldi Joseph	EVP, Chief Business Officer	96	$0	$7.09M	2026-06-26
Jenne Kyle	EVP, Chf GL Pdt Str Ofcr	22	$0	$3.42M	2026-04-16
PARSHALL B LYNNE	Director	162	$0	$17.99M	2026-04-15
HOUGEN ELIZABETH L	SVP, Finance & CFO	185	$0	$27.72M	2026-03-17
WENDER JOSEPH H	Director	101	$0	$10.14M	2025-12-01
Geary Richard S	SVP, Development	182	$0	$23.74M	2025-11-06
Cadoret-Manier Onaiza	EVP,Chf GL Pdt Str & Oper Ofc	39	$0	$794.6K	2024-02-02
MUTO FREDERICK T	Director	82	$0	$3.65M	2022-07-15
CROOKE STANLEY T	Executive Chairman of Board	386	$0	$50.34M	2021-01-26
Castleman Breaux	Director	40	$0	$600.0K	2020-07-06
McDevitt Damien	Chief Business Officer	8	$0	$0	2019-07-15
Boyce Sarah	Chief Business Officer	23	$0	$212.8K	2018-01-16

Trade history

Insider	Role	Code	Trade	Filed	Shares	Price	Value	Owned after
Swayze Eric	EVP Research	S Sale	2026-10-16	2026-10-19	53	$43.54	$2.3K	390	SEC↗
Devers Shannon L.	EVP, Chief Human Resources O	S Sale	2026-10-16	2026-10-19	1,357	$43.54	$59.1K	17,811	SEC↗
Swayze Eric	EVP Research	M Exercise deriv	2026-10-15	2026-10-19	125	—	$0	486	SEC↗
Swayze Eric	EVP Research	M Exercise	2026-10-15	2026-10-19	125	—	$0	443	SEC↗
Devers Shannon L.	EVP, Chief Human Resources O	M Exercise deriv	2026-10-15	2026-10-19	2,820	—	$0	49,884	SEC↗
Devers Shannon L.	EVP, Chief Human Resources O	M Exercise	2026-10-15	2026-10-19	2,820	—	$0	19,168	SEC↗
Birchler Brian	EVP, Corp and Development Op	J Other	2026-08-31	2026-09-02	58	$51.31	$3.0K	102,883	SEC↗
Monia Brett P	Chief Executive Officer	J Other	2026-08-31	2026-09-02	98	$51.31	$5.0K	242,760	SEC↗
O'NEIL PATRICK R.	EVP CLO & General Counsel	J Other	2026-08-31	2026-09-02	63	$51.31	$3.2K	59,205	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	J Other	2026-08-31	2026-09-02	110	$51.31	$5.6K	60,128	SEC↗
O'NEIL PATRICK R.	EVP CLO & General Counsel	J Other	2026-08-31	2026-09-02	63	$51.31	$3.2K	59,205	SEC↗
Monia Brett P	Chief Executive Officer, Dir	J Other	2026-08-31	2026-09-02	98	$51.31	$5.0K	242,760	SEC↗
Birchler Brian	EVP, Corp and Development Op	J Other	2026-08-31	2026-09-02	58	$51.31	$3.0K	102,883	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	J Other	2026-08-31	2026-09-02	110	$51.31	$5.6K	60,128	SEC↗
Hayden Michael R	Director	P Buy	2026-07-31	2026-07-31	5,000	$51.60	$258.0K	24,000	SEC↗
Hayden Michael R	Director	P Buy	2026-07-31	2026-07-31	5,000	$51.60	$258.0K	24,000	SEC↗
Hayden Michael R	Director	P Buy	2026-07-30	2026-07-31	15,000	$53.38	$800.7K	19,000	SEC↗
Hayden Michael R	Director	P Buy	2026-07-30	2026-07-31	15,000	$53.38	$800.7K	19,000	SEC↗
BERTHELSEN SPENCER R	Director	M Exercise deriv	2026-07-15	2026-07-17	5,220	—	$0	2,301	SEC↗
HERMAN JOAN E	Director	M Exercise deriv	2026-07-15	2026-07-17	5,220	—	$0	2,301	SEC↗
HANTSON LUDWIG	Director	A Award deriv	2026-07-15	2026-07-17	3,399	—	$0	3,399	SEC↗
Reikes Peter N	Director	A Award deriv	2026-07-15	2026-07-17	3,399	—	$0	3,399	SEC↗
BERTHELSEN SPENCER R	Director	M Exercise	2026-07-15	2026-07-17	5,220	—	$0	161,233	SEC↗
HERMAN JOAN E	Director	M Exercise	2026-07-15	2026-07-17	5,220	—	$0	51,306	SEC↗
Diaz Allene M.	Director	M Exercise deriv	2026-07-07	2026-07-09	10,111	—	$0	0	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	J Other deriv	2026-07-07	2026-07-09	15,000	—	$0	12,109	SEC↗
Kordasiewicz Holly B.	EVP, Chief Development Offic	S Sale	2026-07-07	2026-07-09	362	$84.30	$30.5K	22,096	SEC↗
Diaz Allene M.	Director	M Exercise	2026-07-07	2026-07-09	10,111	$47.11	$476.3K	13,922	SEC↗
Diaz Allene M.	Director	S Sale	2026-07-07	2026-07-09	10,111	$85.42	$863.7K	3,811	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	J Other	2026-07-07	2026-07-09	15,000	—	$0	15,000	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	S Sale	2026-07-07	2026-07-09	5,536	$83.58	$462.7K	75,018	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	S Sale	2026-07-07	2026-07-09	15,000	$85.46	$1.28M	0	SEC↗
BERTHELSEN SPENCER R	Director	A Award deriv	2026-07-01	2026-07-06	2,301	—	$0	7,521	SEC↗
BERTHELSEN SPENCER R	Director	A Award deriv	2026-07-01	2026-07-06	5,369	—	$0	5,369	SEC↗
Diaz Allene M.	Director	A Award deriv	2026-07-01	2026-07-06	2,301	—	$0	7,521	SEC↗
Diaz Allene M.	Director	A Award deriv	2026-07-01	2026-07-06	5,369	—	$0	5,369	SEC↗
Hayden Michael R	Director	A Award deriv	2026-07-01	2026-07-06	2,301	—	$0	12,198	SEC↗
Hayden Michael R	Director	A Award deriv	2026-07-01	2026-07-06	5,369	—	$0	5,369	SEC↗
KLEIN JOSEPH III	Director	M Exercise deriv	2026-07-01	2026-07-06	11,518	—	$0	0	SEC↗
KLEIN JOSEPH III	Director	A Award deriv	2026-07-01	2026-07-06	2,301	—	$0	16,277	SEC↗
KLEIN JOSEPH III	Director	A Award deriv	2026-07-01	2026-07-06	5,369	—	$0	5,369	SEC↗
HERMAN JOAN E	Director	A Award deriv	2026-07-01	2026-07-06	5,369	—	$0	5,369	SEC↗
HERMAN JOAN E	Director	A Award deriv	2026-07-01	2026-07-06	2,301	—	$0	7,521	SEC↗
LOSCALZO JOSEPH	Director	A Award deriv	2026-07-01	2026-07-06	2,301	—	$0	7,521	SEC↗
LOSCALZO JOSEPH	Director	A Award deriv	2026-07-01	2026-07-06	5,369	—	$0	5,369	SEC↗
YANG MICHAEL J.	Director	A Award deriv	2026-07-01	2026-07-06	2,301	—	$0	9,451	SEC↗
YANG MICHAEL J.	Director	A Award deriv	2026-07-01	2026-07-06	5,369	—	$0	5,369	SEC↗
KLEIN JOSEPH III	Director	S Sale	2026-07-01	2026-07-06	11,419	$79.04	$902.6K	11,014	SEC↗
KLEIN JOSEPH III	Director	S Sale	2026-07-01	2026-07-06	99	$79.45	$7.9K	22,433	SEC↗
KLEIN JOSEPH III	Director	M Exercise	2026-07-01	2026-07-06	11,518	$39.94	$460.0K	22,532	SEC↗
Monia Brett P	Chief Executive Officer	M Exercise deriv	2026-06-26	2026-06-26	50,000	—	$0	99,872	SEC↗
Schneider Eugene	EVP, Chf Clinical Develop Of	M Exercise deriv	2026-06-26	2026-06-30	26,000	—	$0	26,000	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	M Exercise deriv	2026-06-26	2026-06-30	1,769	—	$0	0	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	M Exercise deriv	2026-06-26	2026-06-30	3,866	—	$0	0	SEC↗
Monia Brett P	Chief Executive Officer	S Sale	2026-06-26	2026-06-26	50,000	$80.59	$4.03M	245,571	SEC↗
Monia Brett P	Chief Executive Officer	M Exercise	2026-06-26	2026-06-26	50,000	$56.78	$2.84M	295,571	SEC↗
Schneider Eugene	EVP, Chf Clinical Develop Of	S Sale	2026-06-26	2026-06-30	26,000	$81.05	$2.11M	77,114	SEC↗
Schneider Eugene	EVP, Chf Clinical Develop Of	M Exercise	2026-06-26	2026-06-30	26,000	$60.89	$1.58M	103,114	SEC↗
O'NEIL PATRICK R.	EVP CLO & General Counsel	S Sale	2026-06-26	2026-06-30	3,069	$80.00	$245.5K	61,470	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	S Sale	2026-06-26	2026-06-30	5,635	$80.16	$451.7K	4,669	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	M Exercise	2026-06-26	2026-06-30	1,769	$32.60	$57.7K	10,304	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	M Exercise	2026-06-26	2026-06-30	3,866	$56.78	$219.5K	8,535	SEC↗
Monia Brett P	Chief Executive Officer	M Exercise deriv	2026-06-25	2026-06-26	21,072	—	$0	0	SEC↗
Swayze Eric	EVP Research	S Sale	2026-06-25	2026-06-26	10,602	$79.18	$839.5K	21,759	SEC↗
Monia Brett P	Chief Executive Officer	S Sale	2026-06-25	2026-06-26	21,072	$78.49	$1.65M	245,571	SEC↗
Monia Brett P	Chief Executive Officer	M Exercise	2026-06-25	2026-06-26	21,072	$32.60	$686.9K	266,643	SEC↗
Monia Brett P	Chief Executive Officer	M Exercise deriv	2026-06-24	2026-06-26	14,565	—	$0	21,072	SEC↗
Monia Brett P	Chief Executive Officer	M Exercise	2026-06-24	2026-06-26	14,565	$32.60	$474.8K	260,136	SEC↗
Monia Brett P	Chief Executive Officer	S Sale	2026-06-24	2026-06-26	14,565	$78.41	$1.14M	245,571	SEC↗
BERTHELSEN SPENCER R	Director	M Exercise deriv	2026-06-15	2026-06-16	8,000	—	$0	0	SEC↗
BERTHELSEN SPENCER R	Director	S Sale	2026-06-15	2026-06-16	8,000	$73.49	$587.9K	156,013	SEC↗
BERTHELSEN SPENCER R	Director	M Exercise	2026-06-15	2026-06-16	8,000	$24.42	$195.4K	164,013	SEC↗
Kordasiewicz Holly B.	EVP, Chief Development Offic	M Exercise deriv	2026-06-12	2026-06-16	12,000	—	$0	0	SEC↗
Kordasiewicz Holly B.	EVP, Chief Development Offic	M Exercise deriv	2026-06-12	2026-06-16	21,000	—	$0	0	SEC↗
Kordasiewicz Holly B.	EVP, Chief Development Offic	M Exercise deriv	2026-06-12	2026-06-16	19,895	—	$0	0	SEC↗
Kordasiewicz Holly B.	EVP, Chief Development Offic	M Exercise deriv	2026-06-12	2026-06-16	7,951	—	$0	21,000	SEC↗
Kordasiewicz Holly B.	EVP, Chief Development Offic	M Exercise	2026-06-12	2026-06-16	12,000	$32.60	$391.2K	63,409	SEC↗
Kordasiewicz Holly B.	EVP, Chief Development Offic	M Exercise	2026-06-12	2026-06-16	21,000	$60.89	$1.28M	51,409	SEC↗
Kordasiewicz Holly B.	EVP, Chief Development Offic	M Exercise	2026-06-12	2026-06-16	7,951	$60.89	$484.1K	30,409	SEC↗
Kordasiewicz Holly B.	EVP, Chief Development Offic	S Sale	2026-06-12	2026-06-16	41,004	$73.09	$3.00M	42,300	SEC↗
Kordasiewicz Holly B.	EVP, Chief Development Offic	S Sale	2026-06-12	2026-06-16	19,842	$74.05	$1.47M	22,458	SEC↗
Kordasiewicz Holly B.	EVP, Chief Development Offic	M Exercise	2026-06-12	2026-06-16	19,895	$56.78	$1.13M	83,304	SEC↗
HANTSON LUDWIG	Director	A Award deriv	2026-06-04	2026-06-08	10,753	—	$0	10,753	SEC↗
Reikes Peter N	Director	A Award deriv	2026-06-04	2026-06-08	10,753	—	$0	10,753	SEC↗
BERTHELSEN SPENCER R	Director	M Exercise deriv	2026-06-01	2026-06-03	8,000	—	$0	8,000	SEC↗
BERTHELSEN SPENCER R	Director	S Sale	2026-06-01	2026-06-03	8,000	$75.67	$605.4K	156,013	SEC↗
BERTHELSEN SPENCER R	Director	M Exercise	2026-06-01	2026-06-03	8,000	$24.42	$195.4K	164,013	SEC↗
Monia Brett P	Chief Executive Officer	M Exercise deriv	2026-05-14	2026-05-15	3,220	—	$0	35,637	SEC↗
Monia Brett P	Chief Executive Officer	M Exercise	2026-05-14	2026-05-15	3,220	$32.60	$105.0K	245,882	SEC↗
Monia Brett P	Chief Executive Officer	S Sale	2026-05-14	2026-05-15	3,220	$78.68	$253.3K	242,662	SEC↗
Monia Brett P	Chief Executive Officer	M Exercise deriv	2026-05-13	2026-05-15	1,316	—	$0	38,857	SEC↗
Monia Brett P	Chief Executive Officer	S Sale	2026-05-13	2026-05-15	1,316	$78.01	$102.7K	242,662	SEC↗
Monia Brett P	Chief Executive Officer	M Exercise	2026-05-13	2026-05-15	1,316	$32.60	$42.9K	243,978	SEC↗
LOSCALZO JOSEPH	Director	M Exercise deriv	2026-05-04	2026-05-06	10,321	—	$0	0	SEC↗
LOSCALZO JOSEPH	Director	M Exercise deriv	2026-05-04	2026-05-06	10,968	—	$0	0	SEC↗
LOSCALZO JOSEPH	Director	M Exercise deriv	2026-05-04	2026-05-06	12,000	—	$0	0	SEC↗
LOSCALZO JOSEPH	Director	M Exercise deriv	2026-05-04	2026-05-06	16,000	—	$0	0	SEC↗
LOSCALZO JOSEPH	Director	M Exercise deriv	2026-05-04	2026-05-06	16,000	—	$0	0	SEC↗
LOSCALZO JOSEPH	Director	M Exercise deriv	2026-05-04	2026-05-06	12,000	—	$0	0	SEC↗
LOSCALZO JOSEPH	Director	S Sale	2026-05-04	2026-05-06	59,508	$74.90	$4.46M	54,111	SEC↗
LOSCALZO JOSEPH	Director	M Exercise	2026-05-04	2026-05-06	16,000	$64.80	$1.04M	113,619	SEC↗
LOSCALZO JOSEPH	Director	S Sale	2026-05-04	2026-05-06	17,781	$75.58	$1.34M	36,330	SEC↗
LOSCALZO JOSEPH	Director	M Exercise	2026-05-04	2026-05-06	12,000	$60.20	$722.4K	97,619	SEC↗
LOSCALZO JOSEPH	Director	M Exercise	2026-05-04	2026-05-06	16,000	$42.88	$686.1K	85,619	SEC↗
LOSCALZO JOSEPH	Director	M Exercise	2026-05-04	2026-05-06	10,321	$41.08	$424.0K	69,619	SEC↗
LOSCALZO JOSEPH	Director	M Exercise	2026-05-04	2026-05-06	12,000	$40.05	$480.6K	59,298	SEC↗
LOSCALZO JOSEPH	Director	M Exercise	2026-05-04	2026-05-06	10,968	$38.06	$417.4K	47,298	SEC↗
KLEIN JOSEPH III	Director	M Exercise deriv	2026-05-01	2026-05-05	10,111	—	$0	0	SEC↗
KLEIN JOSEPH III	Director	S Sale	2026-05-01	2026-05-05	1,431	$74.45	$106.5K	11,014	SEC↗
KLEIN JOSEPH III	Director	M Exercise	2026-05-01	2026-05-05	10,111	$47.11	$476.3K	21,125	SEC↗
KLEIN JOSEPH III	Director	S Sale	2026-05-01	2026-05-05	8,680	$73.35	$636.7K	12,445	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	S Sale	2026-04-28	2026-04-30	1,626	$71.79	$116.7K	44,909	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	S Sale	2026-04-16	2026-04-17	5,619	$74.56	$419.0K	46,535	SEC↗
Birchler Brian	EVP, Corp and Development Op	S Sale	2026-04-16	2026-04-17	973	$75.04	$73.0K	67,500	SEC↗
Jenne Kyle	EVP, Chf GL Pdt Str Ofcr	S Sale	2026-04-16	2026-04-17	4,902	$75.17	$368.5K	23,713	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	M Exercise deriv	2026-04-15	2026-04-17	10,837	—	$0	48,312	SEC↗
Birchler Brian	EVP, Corp and Development Op	M Exercise deriv	2026-04-15	2026-04-17	1,875	—	$0	48,926	SEC↗
Jenne Kyle	EVP, Chf GL Pdt Str Ofcr	M Exercise deriv	2026-04-15	2026-04-17	12,226	—	$0	74,402	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	M Exercise	2026-04-15	2026-04-17	10,837	—	$0	52,154	SEC↗
Birchler Brian	EVP, Corp and Development Op	M Exercise	2026-04-15	2026-04-17	1,875	—	$0	68,473	SEC↗
Jenne Kyle	EVP, Chf GL Pdt Str Ofcr	M Exercise	2026-04-15	2026-04-17	12,226	—	$0	28,615	SEC↗
PARSHALL B LYNNE	Director	S Sale	2026-04-15	2026-04-17	4,466	$76.19	$340.3K	51,878	SEC↗
PARSHALL B LYNNE	Director	S Sale	2026-04-15	2026-04-17	534	$76.97	$41.1K	51,344	SEC↗
Devers Shannon L.	EVP, Chief Human Resources O	S Sale	2026-04-02	2026-04-02	6,193	$74.05	$458.6K	16,348	SEC↗
KLEIN JOSEPH III	Director	M Exercise deriv	2026-04-01	2026-04-02	12,000	—	$0	0	SEC↗
KLEIN JOSEPH III	Director	M Exercise deriv	2026-04-01	2026-04-02	10,321	—	$0	0	SEC↗
KLEIN JOSEPH III	Director	S Sale	2026-04-01	2026-04-02	20,105	$75.50	$1.52M	13,230	SEC↗
KLEIN JOSEPH III	Director	S Sale	2026-04-01	2026-04-02	2,216	$75.95	$168.3K	11,014	SEC↗
KLEIN JOSEPH III	Director	M Exercise	2026-04-01	2026-04-02	12,000	$38.06	$456.7K	23,014	SEC↗
KLEIN JOSEPH III	Director	M Exercise	2026-04-01	2026-04-02	10,321	$41.08	$424.0K	33,335	SEC↗
Schneider Eugene	EVP, Chf Clinical Develop Of	S Sale	2026-03-19	2026-03-23	5,812	$70.97	$412.5K	63,890	SEC↗
HOUGEN ELIZABETH L	EVP, Finance & CFO	S Sale	2026-03-17	2026-03-18	10,172	$73.21	$744.7K	82,660	SEC↗
HOUGEN ELIZABETH L	EVP, Finance & CFO	M Exercise deriv	2026-03-16	2026-03-18	61,041	—	$0	0	SEC↗
HOUGEN ELIZABETH L	EVP, Finance & CFO	M Exercise deriv	2026-03-16	2026-03-18	20,541	—	$0	5,405	SEC↗
HOUGEN ELIZABETH L	EVP, Finance & CFO	M Exercise deriv	2026-03-16	2026-03-18	33,118	—	$0	0	SEC↗
HOUGEN ELIZABETH L	EVP, Finance & CFO	M Exercise deriv	2026-03-16	2026-03-18	60,299	—	$0	0	SEC↗
HOUGEN ELIZABETH L	EVP, Finance & CFO	M Exercise	2026-03-16	2026-03-18	20,541	$37.58	$771.9K	307,880	SEC↗
HOUGEN ELIZABETH L	EVP, Finance & CFO	S Sale	2026-03-16	2026-03-18	9,440	$72.77	$686.9K	92,832	SEC↗
HOUGEN ELIZABETH L	EVP, Finance & CFO	M Exercise	2026-03-16	2026-03-18	60,299	$60.89	$3.67M	193,180	SEC↗
HOUGEN ELIZABETH L	EVP, Finance & CFO	M Exercise	2026-03-16	2026-03-18	61,041	$56.78	$3.47M	254,221	SEC↗
HOUGEN ELIZABETH L	EVP, Finance & CFO	S Sale	2026-03-16	2026-03-18	205,608	$72.38	$14.88M	102,272	SEC↗
HOUGEN ELIZABETH L	EVP, Finance & CFO	M Exercise	2026-03-16	2026-03-18	33,118	$32.60	$1.08M	287,339	SEC↗
Jenne Kyle	EVP, Chf GL Pdt Str Ofcr	M Exercise deriv	2026-03-10	2026-03-11	4,675	—	$0	14,025	SEC↗
Jenne Kyle	EVP, Chf GL Pdt Str Ofcr	M Exercise deriv	2026-03-10	2026-03-11	32,602	—	$0	32,601	SEC↗
Monia Brett P	Chief Executive Officer	M Exercise deriv	2026-03-10	2026-03-11	34,103	—	$0	0	SEC↗
Jenne Kyle	EVP, Chf GL Pdt Str Ofcr	M Exercise	2026-03-10	2026-03-11	4,675	$34.69	$162.2K	16,389	SEC↗
Jenne Kyle	EVP, Chf GL Pdt Str Ofcr	S Sale	2026-03-10	2026-03-11	21,191	$75.50	$1.60M	27,800	SEC↗
Jenne Kyle	EVP, Chf GL Pdt Str Ofcr	S Sale	2026-03-10	2026-03-11	16,086	$76.30	$1.23M	11,714	SEC↗
Jenne Kyle	EVP, Chf GL Pdt Str Ofcr	M Exercise	2026-03-10	2026-03-11	32,602	$46.10	$1.50M	48,991	SEC↗
Monia Brett P	Chief Executive Officer	M Exercise	2026-03-10	2026-03-11	34,103	$60.89	$2.08M	276,765	SEC↗
Monia Brett P	Chief Executive Officer	S Sale	2026-03-10	2026-03-11	17,591	$76.34	$1.34M	242,662	SEC↗
Monia Brett P	Chief Executive Officer	S Sale	2026-03-10	2026-03-11	16,512	$75.47	$1.25M	260,253	SEC↗
Monia Brett P	Chief Executive Officer	M Exercise deriv	2026-03-09	2026-03-11	40,822	—	$0	107,632	SEC↗
Monia Brett P	Chief Executive Officer	M Exercise deriv	2026-03-09	2026-03-11	73,529	—	$0	34,103	SEC↗
Monia Brett P	Chief Executive Officer	M Exercise	2026-03-09	2026-03-11	40,822	$60.89	$2.49M	295,803	SEC↗
Monia Brett P	Chief Executive Officer	M Exercise	2026-03-09	2026-03-11	73,529	$60.89	$4.48M	369,332	SEC↗
Monia Brett P	Chief Executive Officer	S Sale	2026-03-09	2026-03-11	7,382	$74.11	$547.1K	361,950	SEC↗
Monia Brett P	Chief Executive Officer	S Sale	2026-03-09	2026-03-11	117,604	$75.26	$8.85M	244,346	SEC↗
Monia Brett P	Chief Executive Officer	S Sale	2026-03-09	2026-03-11	1,684	$75.58	$127.3K	242,662	SEC↗
O'NEIL PATRICK R.	EVP CLO & General Counsel	S Sale	2026-03-09	2026-03-11	10,148	$75.25	$763.6K	62,211	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	M Exercise deriv	2026-03-04	2026-03-05	238	—	$0	3,866	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	M Exercise deriv	2026-03-04	2026-03-05	201	—	$0	1,769	SEC↗
LOSCALZO JOSEPH	Director	M Exercise deriv	2026-03-04	2026-03-05	200	—	$0	10,968	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	S Sale	2026-03-04	2026-03-05	201	$80.00	$16.1K	4,347	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	M Exercise	2026-03-04	2026-03-05	201	$32.60	$6.6K	4,548	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	S Sale	2026-03-04	2026-03-05	238	$80.00	$19.0K	4,347	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	M Exercise	2026-03-04	2026-03-05	238	$56.78	$13.5K	4,585	SEC↗
LOSCALZO JOSEPH	Director	S Sale	2026-03-04	2026-03-05	200	$80.00	$16.0K	36,330	SEC↗
LOSCALZO JOSEPH	Director	M Exercise	2026-03-04	2026-03-05	200	$38.06	$7.6K	36,530	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	M Exercise deriv	2026-03-03	2026-03-05	820	—	$0	4,104	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	M Exercise deriv	2026-03-03	2026-03-05	879	—	$0	1,970	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	M Exercise deriv	2026-03-03	2026-03-05	48,626	—	$0	0	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	M Exercise deriv	2026-03-03	2026-03-05	16,463	—	$0	2,406	SEC↗
Devers Shannon L.	EVP, Chief Human Resources O	M Exercise deriv	2026-03-03	2026-03-05	385	—	$0	8,877	SEC↗
Devers Shannon L.	EVP, Chief Human Resources O	M Exercise deriv	2026-03-03	2026-03-05	3,760	—	$0	11,280	SEC↗
Devers Shannon L.	EVP, Chief Human Resources O	M Exercise deriv	2026-03-03	2026-03-05	3,510	—	$0	5,744	SEC↗
Devers Shannon L.	EVP, Chief Human Resources O	M Exercise deriv	2026-03-03	2026-03-05	5,500	—	$0	16,500	SEC↗
Devers Shannon L.	EVP, Chief Human Resources O	M Exercise deriv	2026-03-03	2026-03-05	6,951	—	$0	928	SEC↗
Diaz Allene M.	Director	M Exercise deriv	2026-03-03	2026-03-05	12,000	—	$0	0	SEC↗
Diaz Allene M.	Director	M Exercise deriv	2026-03-03	2026-03-05	18,000	—	$0	0	SEC↗
Diaz Allene M.	Director	M Exercise deriv	2026-03-03	2026-03-05	10,321	—	$0	0	SEC↗
KLEIN JOSEPH III	Director	M Exercise deriv	2026-03-03	2026-03-05	12,000	—	$0	0	SEC↗
KLEIN JOSEPH III	Director	M Exercise deriv	2026-03-03	2026-03-05	4,000	—	$0	0	SEC↗
LOSCALZO JOSEPH	Director	M Exercise deriv	2026-03-03	2026-03-05	832	—	$0	11,168	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	S Sale	2026-03-03	2026-03-05	4,096	$79.36	$325.1K	41,317	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	M Exercise	2026-03-03	2026-03-05	820	$56.78	$46.6K	5,592	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	M Exercise	2026-03-03	2026-03-05	879	$32.60	$28.7K	6,471	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	S Sale	2026-03-03	2026-03-05	36	$81.01	$2.9K	4,347	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	S Sale	2026-03-03	2026-03-05	2,088	$80.41	$167.9K	4,383	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	S Sale	2026-03-03	2026-03-05	802	$80.76	$64.8K	80,554	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	S Sale	2026-03-03	2026-03-05	12,687	$79.88	$1.01M	81,356	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	S Sale	2026-03-03	2026-03-05	71,600	$79.10	$5.66M	94,043	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	M Exercise	2026-03-03	2026-03-05	48,626	$60.89	$2.96M	165,643	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	M Exercise	2026-03-03	2026-03-05	16,463	$32.60	$536.7K	117,017	SEC↗
Devers Shannon L.	EVP, Chief Human Resources O	S Sale	2026-03-03	2026-03-05	755	$80.84	$61.0K	22,541	SEC↗
Devers Shannon L.	EVP, Chief Human Resources O	S Sale	2026-03-03	2026-03-05	5,030	$80.00	$402.4K	23,296	SEC↗
Devers Shannon L.	EVP, Chief Human Resources O	S Sale	2026-03-03	2026-03-05	14,321	$79.12	$1.13M	28,326	SEC↗
Devers Shannon L.	EVP, Chief Human Resources O	M Exercise	2026-03-03	2026-03-05	385	$52.87	$20.4K	42,647	SEC↗
Devers Shannon L.	EVP, Chief Human Resources O	M Exercise	2026-03-03	2026-03-05	6,951	$32.60	$226.6K	42,262	SEC↗
Devers Shannon L.	EVP, Chief Human Resources O	M Exercise	2026-03-03	2026-03-05	5,500	$34.69	$190.8K	35,311	SEC↗
Devers Shannon L.	EVP, Chief Human Resources O	M Exercise	2026-03-03	2026-03-05	3,510	$37.58	$131.9K	26,051	SEC↗
Devers Shannon L.	EVP, Chief Human Resources O	M Exercise	2026-03-03	2026-03-05	3,760	$40.85	$153.6K	29,811	SEC↗
Diaz Allene M.	Director	M Exercise	2026-03-03	2026-03-05	10,321	$41.08	$424.0K	28,689	SEC↗
Diaz Allene M.	Director	M Exercise	2026-03-03	2026-03-05	12,000	$38.06	$456.7K	40,689	SEC↗
Diaz Allene M.	Director	M Exercise	2026-03-03	2026-03-05	18,000	$40.05	$720.9K	58,689	SEC↗
Diaz Allene M.	Director	S Sale	2026-03-03	2026-03-05	39,265	$79.11	$3.11M	19,424	SEC↗
Diaz Allene M.	Director	S Sale	2026-03-03	2026-03-05	1,005	$80.80	$81.2K	3,811	SEC↗
Diaz Allene M.	Director	S Sale	2026-03-03	2026-03-05	14,608	$79.88	$1.17M	4,816	SEC↗
KLEIN JOSEPH III	Director	S Sale	2026-03-03	2026-03-05	1,012	$80.82	$81.8K	11,014	SEC↗
KLEIN JOSEPH III	Director	M Exercise	2026-03-03	2026-03-05	12,000	$40.05	$480.6K	28,346	SEC↗
KLEIN JOSEPH III	Director	S Sale	2026-03-03	2026-03-05	6,794	$80.00	$543.5K	12,026	SEC↗
KLEIN JOSEPH III	Director	S Sale	2026-03-03	2026-03-05	13,526	$79.17	$1.07M	18,820	SEC↗
KLEIN JOSEPH III	Director	M Exercise	2026-03-03	2026-03-05	4,000	$42.88	$171.5K	32,346	SEC↗
LOSCALZO JOSEPH	Director	S Sale	2026-03-03	2026-03-05	832	$80.33	$66.8K	36,330	SEC↗
LOSCALZO JOSEPH	Director	M Exercise	2026-03-03	2026-03-05	832	$38.06	$31.7K	37,162	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	J Other	2026-02-27	2026-03-03	261	$48.87	$12.8K	100,554	SEC↗
Birchler Brian	EVP, Corp and Development Op	J Other	2026-02-27	2026-03-03	351	$48.87	$17.2K	66,598	SEC↗
Monia Brett P	Chief Executive Officer	J Other	2026-02-27	2026-03-03	484	$48.87	$23.7K	254,981	SEC↗
O'NEIL PATRICK R.	EVP CLO & General Counsel	J Other	2026-02-27	2026-03-03	376	$48.87	$18.4K	72,359	SEC↗
Swayze Eric	EVP Research	J Other	2026-02-27	2026-03-03	256	$48.87	$12.5K	32,361	SEC↗
Swayze Eric	EVP Research	S Sale	2026-02-13	2026-02-13	9,435	$81.56	$769.5K	38,312	SEC↗
Swayze Eric	EVP Research	S Sale	2026-02-13	2026-02-13	6,207	$82.07	$509.4K	32,105	SEC↗
PARSHALL B LYNNE	Director	S Sale	2026-02-11	2026-02-13	5,000	$82.72	$413.6K	56,344	SEC↗
Monia Brett P	Chief Executive Officer	S Sale	2026-02-06	2026-02-10	29,430	$85.79	$2.52M	254,497	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	M Exercise deriv	2026-02-02	2026-02-04	16,463	—	$0	2,406	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	M Exercise deriv	2026-02-02	2026-02-04	48,626	—	$0	0	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	M Exercise	2026-02-02	2026-02-04	48,626	$60.89	$2.96M	128,919	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	S Sale	2026-02-02	2026-02-04	20,000	$82.60	$1.65M	80,293	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	S Sale	2026-02-02	2026-02-04	48,626	$83.03	$4.04M	80,293	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	M Exercise	2026-02-02	2026-02-04	16,463	$32.60	$536.7K	96,756	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	S Sale	2026-02-02	2026-02-04	16,463	$83.03	$1.37M	80,293	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	J Other	2026-02-02	2026-02-13	0	—	$0	100,293	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	S Sale	2026-01-30	2026-02-02	5,296	$82.96	$439.4K	45,413	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	S Sale	2026-01-30	2026-02-02	5,885	$82.95	$488.2K	100,293	SEC↗
Birchler Brian	EVP, Corp and Development Op	S Sale	2026-01-30	2026-02-02	6,179	$83.03	$513.0K	66,247	SEC↗
HOUGEN ELIZABETH L	EVP, Finance & CFO	S Sale	2026-01-30	2026-02-02	6,988	$83.24	$581.7K	132,881	SEC↗
Monia Brett P	Chief Executive Officer	S Sale	2026-01-30	2026-02-02	62,970	$82.72	$5.21M	283,927	SEC↗
O'NEIL PATRICK R.	EVP CLO & General Counsel	S Sale	2026-01-30	2026-02-02	6,179	$83.53	$516.1K	71,983	SEC↗
Schneider Eugene	EVP, Chf Clinical Develop Of	S Sale	2026-01-30	2026-02-02	6,179	$83.45	$515.6K	69,702	SEC↗
Swayze Eric	EVP Research	S Sale	2026-01-30	2026-02-02	6,179	$82.93	$512.4K	47,747	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	A Award	2026-01-29	2026-02-02	10,278	—	$0	50,709	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	A Award	2026-01-29	2026-02-02	11,421	—	$0	106,178	SEC↗
Birchler Brian	EVP, Corp and Development Op	A Award	2026-01-29	2026-02-02	11,991	—	$0	72,426	SEC↗
HOUGEN ELIZABETH L	EVP, Finance & CFO	A Award	2026-01-29	2026-02-02	13,562	—	$0	139,869	SEC↗
Monia Brett P	Chief Executive Officer	A Award	2026-01-29	2026-02-02	122,214	—	$0	346,897	SEC↗
O'NEIL PATRICK R.	EVP CLO & General Counsel	A Award	2026-01-29	2026-02-02	11,991	—	$0	78,162	SEC↗
Schneider Eugene	EVP, Chf Clinical Develop Of	A Award	2026-01-29	2026-02-02	11,991	—	$0	75,881	SEC↗
Swayze Eric	EVP Research	A Award	2026-01-29	2026-02-02	11,991	—	$0	53,926	SEC↗
Devers Shannon L.	EVP, Chief Human Resources O	S Sale	2026-01-22	2026-01-23	3,977	$81.34	$323.5K	22,541	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	S Sale	2026-01-16	2026-01-20	1,149	$75.78	$87.1K	4,772	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	S Sale	2026-01-16	2026-01-20	6,907	$75.75	$523.2K	40,431	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	S Sale	2026-01-16	2026-01-20	8,977	$75.15	$674.6K	94,757	SEC↗
Birchler Brian	EVP, Corp and Development Op	S Sale	2026-01-16	2026-01-20	8,480	$75.11	$636.9K	60,435	SEC↗
Devers Shannon L.	EVP, Chief Human Resources O	S Sale	2026-01-16	2026-01-20	8,353	$75.95	$634.4K	26,518	SEC↗
HOUGEN ELIZABETH L	EVP, Finance & CFO	S Sale	2026-01-16	2026-01-20	12,922	$75.22	$972.0K	126,307	SEC↗
Jenne Kyle	EVP, Chf GL Pdt Str Ofcr	S Sale	2026-01-16	2026-01-20	1,823	$75.96	$138.5K	16,389	SEC↗
Kordasiewicz Holly B.	EVP, Chief Development Offic	S Sale	2026-01-16	2026-01-20	4,141	$75.66	$313.3K	14,718	SEC↗
Monia Brett P	Chief Executive Officer	S Sale	2026-01-16	2026-01-20	44,034	$74.82	$3.29M	224,683	SEC↗
O'NEIL PATRICK R.	EVP CLO & General Counsel	S Sale	2026-01-16	2026-01-20	9,191	$75.84	$697.0K	66,171	SEC↗
Schneider Eugene	EVP, Chf Clinical Develop Of	S Sale	2026-01-16	2026-01-20	9,302	$75.59	$703.1K	63,890	SEC↗
Swayze Eric	EVP Research	S Sale	2026-01-16	2026-01-20	49	$75.97	$3.7K	318	SEC↗
Swayze Eric	EVP Research	S Sale	2026-01-16	2026-01-20	9,884	$75.34	$744.7K	41,935	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	M Exercise deriv	2026-01-15	2026-01-20	17,037	—	$0	49,474	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	A Award deriv	2026-01-15	2026-01-20	9,675	—	$0	59,149	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	M Exercise deriv	2026-01-15	2026-01-20	2,850	—	$0	5,474	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	A Award deriv	2026-01-15	2026-01-20	3,900	—	$0	9,374	SEC↗
Baroldi Joseph	EVP, Chief Business Officer	A Award deriv	2026-01-15	2026-01-20	25,800	—	$0	77,090	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	M Exercise deriv	2026-01-15	2026-01-20	21,055	—	$0	17,434	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	A Award deriv	2026-01-15	2026-01-20	9,675	—	$0	27,109	SEC↗
BENNETT C FRANK	EVP, Chief Scientific Office	A Award deriv	2026-01-15	2026-01-20	25,800	—	$0	89,282	SEC↗
Birchler Brian	EVP, Corp and Development Op	M Exercise deriv	2026-01-15	2026-01-20	20,089	—	$0	41,126	SEC↗
Birchler Brian	EVP, Corp and Development Op	A Award deriv	2026-01-15	2026-01-20	9,675	—	$0	50,801	SEC↗
Birchler Brian	EVP, Corp and Development Op	A Award deriv	2026-01-15	2026-01-20	25,800	—	$0	79,138	SEC↗
Devers Shannon L.	EVP, Chief Human Resources O	A Award deriv	2026-01-15	2026-01-20	25,800	—	$0	47,800	SEC↗
Devers Shannon L.	EVP, Chief Human Resources O	M Exercise deriv	2026-01-15	2026-01-20	17,377	—	$0	43,029	SEC↗
Devers Shannon L.	EVP, Chief Human Resources O	A Award deriv	2026-01-15	2026-01-20	9,675	—	$0	52,704	SEC↗
HOUGEN ELIZABETH L	EVP, Finance & CFO	M Exercise deriv	2026-01-15	2026-01-20	28,729	—	$0	55,940	SEC↗
HOUGEN ELIZABETH L	EVP, Finance & CFO	A Award deriv	2026-01-15	2026-01-20	12,885	—	$0	68,825	SEC↗
HOUGEN ELIZABETH L	EVP, Finance & CFO	A Award deriv	2026-01-15	2026-01-20	34,360	—	$0	120,995	SEC↗
Jenne Kyle	EVP, Chf GL Pdt Str Ofcr	A Award deriv	2026-01-15	2026-01-20	25,800	—	$0	44,500	SEC↗
Jenne Kyle	EVP, Chf GL Pdt Str Ofcr	M Exercise deriv	2026-01-15	2026-01-20	7,013	—	$0	29,664	SEC↗
Jenne Kyle	EVP, Chf GL Pdt Str Ofcr	A Award deriv	2026-01-15	2026-01-20	9,675	—	$0	37,725	SEC↗
Kordasiewicz Holly B.	EVP, Chief Development Offic	M Exercise deriv	2026-01-15	2026-01-20	11,119	—	$0	20,830	SEC↗
Kordasiewicz Holly B.	EVP, Chief Development Offic	A Award deriv	2026-01-15	2026-01-20	11,250	—	$0	45,730	SEC↗
Kordasiewicz Holly B.	EVP, Chief Development Offic	A Award deriv	2026-01-15	2026-01-20	13,650	—	$0	34,480	SEC↗
Monia Brett P	Chief Executive Officer	M Exercise deriv	2026-01-15	2026-01-20	89,145	—	$0	163,014	SEC↗
Monia Brett P	Chief Executive Officer	A Award deriv	2026-01-15	2026-01-20	113,880	—	$0	744,081	SEC↗
Monia Brett P	Chief Executive Officer	A Award deriv	2026-01-15	2026-01-20	42,705	—	$0	205,719	SEC↗
O'NEIL PATRICK R.	EVP CLO & General Counsel	A Award deriv	2026-01-15	2026-01-20	25,800	—	$0	90,601	SEC↗
O'NEIL PATRICK R.	EVP CLO & General Counsel	A Award deriv	2026-01-15	2026-01-20	9,675	—	$0	48,926	SEC↗
O'NEIL PATRICK R.	EVP CLO & General Counsel	M Exercise deriv	2026-01-15	2026-01-20	21,473	—	$0	39,251	SEC↗
Schneider Eugene	EVP, Chf Clinical Develop Of	A Award deriv	2026-01-15	2026-01-20	25,800	—	$0	91,237	SEC↗
Schneider Eugene	EVP, Chf Clinical Develop Of	M Exercise deriv	2026-01-15	2026-01-20	21,685	—	$0	39,251	SEC↗
Schneider Eugene	EVP, Chf Clinical Develop Of	A Award deriv	2026-01-15	2026-01-20	9,675	—	$0	48,926	SEC↗
Swayze Eric	EVP Research	A Award deriv	2026-01-15	2026-01-20	225	—	$0	611	SEC↗
Swayze Eric	EVP Research	M Exercise deriv	2026-01-15	2026-01-20	111	—	$0	386	SEC↗
Swayze Eric	EVP Research	A Award deriv	2026-01-15	2026-01-20	9,675	—	$0	48,926	SEC↗
Swayze Eric	EVP Research	A Award deriv	2026-01-15	2026-01-20	25,800	—	$0	90,282	SEC↗
Swayze Eric	EVP Research	M Exercise deriv	2026-01-15	2026-01-20	21,366	—	$0	39,251	SEC↗
YANG MICHAEL J.	Director	M Exercise deriv	2026-01-15	2026-01-20	1,930	—	$0	7,150	SEC↗