ISIS

ISIS PHARMACEUTICALS INCCIK 874015 ☆ Sign in to watch Congress trades

Open-mkt buys · 90d

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0 trades · 0 insiders

Open-mkt sales · 90d

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0 trades · 0 insiders

Net · 90d

Insiders on file

AI insights for ISIS PRO

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AI insights for ISIS

Insider sentiment score with a plain-English explanation, conviction score on every buy, and how the stock performed 30 and 90 days after past insider buys.

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Daily buy vs sell · 90 days

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Insiders

Insider	Role	Trades	Bought	Sold	Last trade
BENNETT C FRANK	Senior Vice President	99	$0	$5.49M	2015-12-16
O'NEIL PATRICK R.	SVP, Legal and General Counsel	223	$0	$5.28M	2015-12-01
KLEIN JOSEPH III	Director	148	$0	$3.41M	2015-11-11
PARSHALL B LYNNE	Director, COO	207	$0	$22.21M	2015-11-09
CROOKE STANLEY T	Chairman, President, CEO	345	$0	$38.69M	2015-10-23
Monia Brett P	VP, Antisense Drug Discovery	98	$0	$5.28M	2015-07-02
MUTO FREDERICK T	Director	29	$0	$1.17M	2015-07-02
BERTHELSEN SPENCER R	Director	61	$0	$306.5K	2015-07-02
WENDER JOSEPH H	Director	48	$0	$4.87M	2015-07-02
Geary Richard S	Sr VP, Development	129	$0	$7.84M	2015-07-01
Castleman Breaux	Director	18	$0	$0	2015-07-01
LOSCALZO JOSEPH	Director	10	$0	$0	2015-07-01
HOUGEN ELIZABETH L	SVP, Finance and CFO	67	$0	$3.82M	2015-07-01
Boyce Sarah	Chief Business Officer	2	$0	$0	2015-01-15
REED JOHN C	Director	14	$0	$402.2K	2012-09-06

Trade history

Insider	Role	Code	Trade	Filed	Shares	Price	Value	Owned after
BENNETT C FRANK	SVP, Antisense Research	M Exercise deriv	2015-12-16	2015-12-17	3,909	—	$0	0	SEC↗
BENNETT C FRANK	SVP, Antisense Research	M Exercise	2015-12-16	2015-12-17	3,909	$14.47	$56.6K	11,225	SEC↗
BENNETT C FRANK	SVP, Antisense Research	S Sale	2015-12-16	2015-12-17	3,909	$58.85	$230.0K	7,316	SEC↗
BENNETT C FRANK	SVP, Antisense Research	M Exercise deriv	2015-12-15	2015-12-17	4,000	—	$0	3,909	SEC↗
BENNETT C FRANK	SVP, Antisense Research	M Exercise	2015-12-15	2015-12-17	4,000	$14.47	$57.9K	11,316	SEC↗
BENNETT C FRANK	SVP, Antisense Research	S Sale	2015-12-15	2015-12-17	4,000	$56.00	$224.0K	7,316	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	M Exercise deriv	2015-12-01	2015-12-02	1,000	—	$0	2,067	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	S Sale	2015-12-01	2015-12-02	1,000	$61.50	$61.5K	6,259	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	M Exercise	2015-12-01	2015-12-02	1,000	$7.25	$7.3K	7,259	SEC↗
KLEIN JOSEPH III	Director	M Exercise deriv	2015-11-11	2015-11-12	3,125	—	$0	2,812	SEC↗
KLEIN JOSEPH III	Director	M Exercise deriv	2015-11-11	2015-11-12	3,750	—	$0	0	SEC↗
KLEIN JOSEPH III	Director	S Sale	2015-11-11	2015-11-12	3,750	$64.18	$240.7K	5,543	SEC↗
KLEIN JOSEPH III	Director	M Exercise	2015-11-11	2015-11-12	3,125	$12.94	$40.4K	8,668	SEC↗
KLEIN JOSEPH III	Director	S Sale	2015-11-11	2015-11-12	3,125	$64.18	$200.6K	5,543	SEC↗
KLEIN JOSEPH III	Director	M Exercise	2015-11-11	2015-11-12	3,750	$9.30	$34.9K	9,293	SEC↗
BENNETT C FRANK	SVP, Antisense Research	M Exercise deriv	2015-11-10	2015-11-12	5,000	—	$0	7,909	SEC↗
BENNETT C FRANK	SVP, Antisense Research	M Exercise	2015-11-10	2015-11-12	5,000	$14.47	$72.3K	12,316	SEC↗
BENNETT C FRANK	SVP, Antisense Research	S Sale	2015-11-10	2015-11-12	5,000	$64.00	$320.0K	7,316	SEC↗
PARSHALL B LYNNE	COO & Secretary	G Gift deriv	2015-11-09	2015-11-09	1,000	—	$0	1,000	SEC↗
PARSHALL B LYNNE	COO & Secretary	G Gift deriv	2015-11-09	2015-11-09	1,000	—	$0	1,000	SEC↗
PARSHALL B LYNNE	COO & Secretary	G Gift deriv	2015-11-09	2015-11-09	1,000	—	$0	1,000	SEC↗
PARSHALL B LYNNE	COO & Secretary	G Gift deriv	2015-11-09	2015-11-09	4,000	—	$0	8,865	SEC↗
PARSHALL B LYNNE	COO & Secretary	G Gift deriv	2015-11-09	2015-11-09	1,000	—	$0	1,000	SEC↗
BENNETT C FRANK	SVP, Antisense Research	M Exercise deriv	2015-11-06	2015-11-09	5,000	—	$0	12,909	SEC↗
BENNETT C FRANK	SVP, Antisense Research	S Sale	2015-11-06	2015-11-09	5,000	$56.00	$280.0K	7,316	SEC↗
BENNETT C FRANK	SVP, Antisense Research	M Exercise	2015-11-06	2015-11-09	5,000	$14.47	$72.3K	12,316	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	M Exercise deriv	2015-11-03	2015-11-04	1,000	—	$0	3,067	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	S Sale	2015-11-03	2015-11-04	1,000	$51.95	$52.0K	6,259	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	M Exercise	2015-11-03	2015-11-04	1,000	$7.25	$7.3K	7,259	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise deriv	2015-10-23	2015-10-23	4,163	—	$0	0	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise deriv	2015-10-23	2015-10-23	20,837	—	$0	101,259	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise deriv	2015-10-23	2015-10-23	2,500	—	$0	2,000	SEC↗
CROOKE STANLEY T	Chairman and CEO	S Sale	2015-10-23	2015-10-23	5,000	$45.30	$226.5K	14,642	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise	2015-10-23	2015-10-23	2,000	$9.22	$18.4K	3,297	SEC↗
CROOKE STANLEY T	Chairman and CEO	S Sale	2015-10-23	2015-10-23	2,000	$44.18	$88.4K	1,297	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise	2015-10-23	2015-10-23	500	$9.22	$4.6K	1,797	SEC↗
CROOKE STANLEY T	Chairman and CEO	S Sale	2015-10-23	2015-10-23	500	$45.30	$22.6K	1,297	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise	2015-10-23	2015-10-23	5,000	$10.29	$51.4K	19,642	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise	2015-10-23	2015-10-23	4,163	$11.27	$46.9K	18,805	SEC↗
CROOKE STANLEY T	Chairman and CEO	S Sale	2015-10-23	2015-10-23	4,163	$43.90	$182.8K	14,642	SEC↗
CROOKE STANLEY T	Chairman and CEO	S Sale	2015-10-23	2015-10-23	15,837	$44.18	$699.7K	14,642	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise	2015-10-23	2015-10-23	15,837	$10.29	$163.0K	30,479	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise deriv	2015-10-21	2015-10-23	15,000	—	$0	4,163	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise deriv	2015-10-21	2015-10-23	1,000	—	$0	0	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise deriv	2015-10-21	2015-10-23	500	—	$0	4,500	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise	2015-10-21	2015-10-23	15,000	$11.27	$169.1K	29,642	SEC↗
CROOKE STANLEY T	Chairman and CEO	S Sale	2015-10-21	2015-10-23	15,000	$43.00	$645.0K	14,642	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise	2015-10-21	2015-10-23	1,000	$11.27	$11.3K	2,297	SEC↗
CROOKE STANLEY T	Chairman and CEO	S Sale	2015-10-21	2015-10-23	1,000	$43.00	$43.0K	1,297	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise	2015-10-21	2015-10-23	500	$9.22	$4.6K	1,797	SEC↗
CROOKE STANLEY T	Chairman and CEO	S Sale	2015-10-21	2015-10-23	500	$43.00	$21.5K	1,297	SEC↗
PARSHALL B LYNNE	COO & Secretary	M Exercise deriv	2015-10-02	2015-10-05	5,436	—	$0	29,354	SEC↗
PARSHALL B LYNNE	COO & Secretary	M Exercise	2015-10-02	2015-10-05	3,436	$14.69	$50.5K	11,579	SEC↗
PARSHALL B LYNNE	COO & Secretary	M Exercise	2015-10-02	2015-10-05	2,000	$14.69	$29.4K	10,143	SEC↗
PARSHALL B LYNNE	COO & Secretary	S Sale	2015-10-02	2015-10-05	2,000	$40.10	$80.2K	8,143	SEC↗
PARSHALL B LYNNE	COO & Secretary	S Sale	2015-10-02	2015-10-05	3,436	$42.39	$145.7K	8,143	SEC↗
PARSHALL B LYNNE	COO & Secretary	M Exercise deriv	2015-10-01	2015-10-05	2,838	—	$0	34,790	SEC↗
PARSHALL B LYNNE	COO & Secretary	M Exercise deriv	2015-10-01	2015-10-05	4,162	—	$0	12,865	SEC↗
PARSHALL B LYNNE	COO & Secretary	M Exercise	2015-10-01	2015-10-05	2,838	$14.69	$41.7K	10,981	SEC↗
PARSHALL B LYNNE	COO & Secretary	S Sale	2015-10-01	2015-10-05	2,838	$40.13	$113.9K	8,143	SEC↗
PARSHALL B LYNNE	COO & Secretary	M Exercise	2015-10-01	2015-10-05	4,162	$7.25	$30.2K	12,305	SEC↗
PARSHALL B LYNNE	COO & Secretary	S Sale	2015-10-01	2015-10-05	4,162	$40.13	$167.0K	8,143	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise deriv	2015-07-06	2015-07-08	5,000	—	$0	19,163	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise deriv	2015-07-06	2015-07-08	1,175	—	$0	5,000	SEC↗
PARSHALL B LYNNE	COO & Secretary	M Exercise deriv	2015-07-06	2015-07-08	4,843	—	$0	17,027	SEC↗
PARSHALL B LYNNE	COO & Secretary	M Exercise deriv	2015-07-06	2015-07-08	1,375	—	$0	0	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise	2015-07-06	2015-07-08	5,000	$11.27	$56.4K	19,642	SEC↗
CROOKE STANLEY T	Chairman and CEO	S Sale	2015-07-06	2015-07-08	1,175	$57.01	$67.0K	1,297	SEC↗
CROOKE STANLEY T	Chairman and CEO	S Sale	2015-07-06	2015-07-08	5,000	$57.01	$285.1K	14,642	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise	2015-07-06	2015-07-08	1,175	$9.22	$10.8K	2,472	SEC↗
PARSHALL B LYNNE	COO & Secretary	M Exercise	2015-07-06	2015-07-08	1,375	$10.29	$14.1K	9,518	SEC↗
PARSHALL B LYNNE	COO & Secretary	S Sale	2015-07-06	2015-07-08	1,375	$57.01	$78.4K	8,143	SEC↗
PARSHALL B LYNNE	COO & Secretary	M Exercise	2015-07-06	2015-07-08	4,843	$7.25	$35.1K	12,986	SEC↗
PARSHALL B LYNNE	COO & Secretary	S Sale	2015-07-06	2015-07-08	4,843	$57.01	$276.1K	8,143	SEC↗
BERTHELSEN SPENCER R	Director	M Exercise deriv	2015-07-02	2015-07-02	312	—	$0	312	SEC↗
KLEIN JOSEPH III	Director	M Exercise deriv	2015-07-02	2015-07-02	312	—	$0	312	SEC↗
MUTO FREDERICK T	Director	M Exercise deriv	2015-07-02	2015-07-02	312	—	$0	312	SEC↗
WENDER JOSEPH H	Director	M Exercise deriv	2015-07-02	2015-07-02	312	—	$0	312	SEC↗
BERTHELSEN SPENCER R	Director	M Exercise	2015-07-02	2015-07-02	312	—	$0	61,843	SEC↗
KLEIN JOSEPH III	Director	M Exercise	2015-07-02	2015-07-02	312	—	$0	5,543	SEC↗
MUTO FREDERICK T	Director	M Exercise	2015-07-02	2015-07-02	312	—	$0	2,543	SEC↗
WENDER JOSEPH H	Director	M Exercise	2015-07-02	2015-07-02	312	—	$0	31,665	SEC↗
Monia Brett P	SVP, Antisense Drug Discover	S Sale	2015-07-02	2015-07-02	198	$56.30	$11.1K	4,355	SEC↗
BERTHELSEN SPENCER R	Director	A Award deriv	2015-07-01	2015-07-02	16,000	—	$0	16,000	SEC↗
BERTHELSEN SPENCER R	Director	A Award deriv	2015-07-01	2015-07-02	2,667	—	$0	2,667	SEC↗
BERTHELSEN SPENCER R	Director	M Exercise deriv	2015-07-01	2015-07-02	667	—	$0	2,000	SEC↗
BERTHELSEN SPENCER R	Director	M Exercise deriv	2015-07-01	2015-07-02	469	—	$0	937	SEC↗
Castleman Breaux	Director	A Award deriv	2015-07-01	2015-07-02	16,000	—	$0	16,000	SEC↗
Castleman Breaux	Director	A Award deriv	2015-07-01	2015-07-02	2,667	—	$0	2,667	SEC↗
Castleman Breaux	Director	M Exercise deriv	2015-07-01	2015-07-02	667	—	$0	2,000	SEC↗
Castleman Breaux	Director	M Exercise deriv	2015-07-01	2015-07-02	469	—	$0	937	SEC↗
Castleman Breaux	Director	M Exercise deriv	2015-07-01	2015-07-02	938	—	$0	1,874	SEC↗
KLEIN JOSEPH III	Director	A Award deriv	2015-07-01	2015-07-02	2,667	—	$0	2,667	SEC↗
KLEIN JOSEPH III	Director	M Exercise deriv	2015-07-01	2015-07-02	469	—	$0	937	SEC↗
KLEIN JOSEPH III	Director	M Exercise deriv	2015-07-01	2015-07-02	667	—	$0	2,000	SEC↗
KLEIN JOSEPH III	Director	A Award deriv	2015-07-01	2015-07-02	16,000	—	$0	16,000	SEC↗
LOSCALZO JOSEPH	Director	A Award deriv	2015-07-01	2015-07-02	16,000	—	$0	16,000	SEC↗
LOSCALZO JOSEPH	Director	A Award deriv	2015-07-01	2015-07-02	2,667	—	$0	2,667	SEC↗
LOSCALZO JOSEPH	Director	M Exercise deriv	2015-07-01	2015-07-02	667	—	$0	2,000	SEC↗
MUTO FREDERICK T	Director	A Award deriv	2015-07-01	2015-07-02	16,000	—	$0	16,000	SEC↗
MUTO FREDERICK T	Director	A Award deriv	2015-07-01	2015-07-02	2,667	—	$0	2,667	SEC↗
MUTO FREDERICK T	Director	M Exercise deriv	2015-07-01	2015-07-02	667	—	$0	2,000	SEC↗
MUTO FREDERICK T	Director	M Exercise deriv	2015-07-01	2015-07-02	469	—	$0	937	SEC↗
WENDER JOSEPH H	Director	A Award deriv	2015-07-01	2015-07-02	16,000	—	$0	16,000	SEC↗
WENDER JOSEPH H	Director	M Exercise deriv	2015-07-01	2015-07-02	667	—	$0	2,000	SEC↗
WENDER JOSEPH H	Director	M Exercise deriv	2015-07-01	2015-07-02	469	—	$0	937	SEC↗
WENDER JOSEPH H	Director	A Award deriv	2015-07-01	2015-07-02	2,667	—	$0	2,667	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise deriv	2015-07-01	2015-07-02	5,000	—	$0	24,163	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise deriv	2015-07-01	2015-07-02	1,175	—	$0	6,175	SEC↗
PARSHALL B LYNNE	COO & Secretary	M Exercise deriv	2015-07-01	2015-07-02	6,218	—	$0	1,375	SEC↗
BERTHELSEN SPENCER R	Director	M Exercise	2015-07-01	2015-07-02	469	—	$0	60,864	SEC↗
BERTHELSEN SPENCER R	Director	M Exercise	2015-07-01	2015-07-02	667	—	$0	61,531	SEC↗
Castleman Breaux	Director	M Exercise	2015-07-01	2015-07-02	667	—	$0	3,481	SEC↗
Castleman Breaux	Director	M Exercise	2015-07-01	2015-07-02	469	—	$0	2,814	SEC↗
Castleman Breaux	Director	M Exercise	2015-07-01	2015-07-02	938	—	$0	2,345	SEC↗
KLEIN JOSEPH III	Director	M Exercise	2015-07-01	2015-07-02	469	—	$0	4,564	SEC↗
KLEIN JOSEPH III	Director	M Exercise	2015-07-01	2015-07-02	667	—	$0	5,231	SEC↗
LOSCALZO JOSEPH	Director	M Exercise	2015-07-01	2015-07-02	667	—	$0	1,605	SEC↗
MUTO FREDERICK T	Director	M Exercise	2015-07-01	2015-07-02	667	—	$0	2,231	SEC↗
MUTO FREDERICK T	Director	M Exercise	2015-07-01	2015-07-02	469	—	$0	1,564	SEC↗
WENDER JOSEPH H	Director	M Exercise	2015-07-01	2015-07-02	667	—	$0	31,353	SEC↗
WENDER JOSEPH H	Director	M Exercise	2015-07-01	2015-07-02	469	—	$0	30,686	SEC↗
BENNETT C FRANK	SVP, Antisense Research	J Other	2015-07-01	2015-07-02	87	$48.59	$4.2K	7,316	SEC↗
CROOKE STANLEY T	Chairman and CEO	S Sale	2015-07-01	2015-07-02	1,175	$57.56	$67.6K	1,297	SEC↗
CROOKE STANLEY T	Chairman and CEO	S Sale	2015-07-01	2015-07-02	5,000	$57.56	$287.8K	14,642	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise	2015-07-01	2015-07-02	5,000	$11.27	$56.4K	19,642	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise	2015-07-01	2015-07-02	1,175	$9.22	$10.8K	2,472	SEC↗
Geary Richard S	SVP, Development	J Other	2015-07-01	2015-07-02	265	$48.59	$12.9K	4,820	SEC↗
HOUGEN ELIZABETH L	SVP, Finance & CFO	J Other	2015-07-01	2015-07-02	40	$48.59	$1.9K	3,427	SEC↗
Monia Brett P	SVP, Antisense Drug Discover	J Other	2015-07-01	2015-07-02	127	$48.59	$6.2K	4,553	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	J Other	2015-07-01	2015-07-02	85	$48.59	$4.1K	6,259	SEC↗
PARSHALL B LYNNE	COO & Secretary	S Sale	2015-07-01	2015-07-02	6,218	$57.56	$357.9K	8,143	SEC↗
PARSHALL B LYNNE	COO & Secretary	J Other	2015-07-01	2015-07-02	71	$48.59	$3.4K	8,143	SEC↗
PARSHALL B LYNNE	COO & Secretary	M Exercise	2015-07-01	2015-07-02	6,218	$10.29	$64.0K	14,361	SEC↗
Monia Brett P	SVP, Antisense Drug Discover	M Exercise deriv	2015-06-08	2015-06-10	7,600	—	$0	0	SEC↗
Monia Brett P	SVP, Antisense Drug Discover	M Exercise	2015-06-08	2015-06-10	7,600	$10.29	$78.2K	12,026	SEC↗
Monia Brett P	SVP, Antisense Drug Discover	S Sale	2015-06-08	2015-06-10	7,600	$66.22	$503.3K	4,426	SEC↗
MUTO FREDERICK T	Director	M Exercise deriv	2015-06-01	2015-06-03	10,000	—	$0	0	SEC↗
MUTO FREDERICK T	Director	S Sale	2015-06-01	2015-06-03	10,000	$66.91	$669.1K	1,095	SEC↗
MUTO FREDERICK T	Director	M Exercise	2015-06-01	2015-06-03	10,000	$3.95	$39.5K	11,095	SEC↗
BERTHELSEN SPENCER R	Director	M Exercise deriv	2015-04-17	2015-04-17	10,000	—	$0	0	SEC↗
BERTHELSEN SPENCER R	Director	M Exercise	2015-04-17	2015-04-17	10,000	$3.95	$39.5K	60,395	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise deriv	2015-04-07	2015-04-08	20,343	—	$0	29,163	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise deriv	2015-04-07	2015-04-08	2,034	—	$0	7,350	SEC↗
PARSHALL B LYNNE	COO & Secretary	M Exercise deriv	2015-04-07	2015-04-08	5,565	—	$0	37,628	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise	2015-04-07	2015-04-08	20,343	$11.27	$229.3K	34,985	SEC↗
CROOKE STANLEY T	Chairman and CEO	S Sale	2015-04-07	2015-04-08	20,343	$63.07	$1.28M	14,642	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise	2015-04-07	2015-04-08	2,034	$9.22	$18.8K	3,331	SEC↗
CROOKE STANLEY T	Chairman and CEO	S Sale	2015-04-07	2015-04-08	2,034	$63.07	$128.3K	1,297	SEC↗
PARSHALL B LYNNE	COO & Secretary	S Sale	2015-04-07	2015-04-08	5,565	$63.07	$351.0K	8,072	SEC↗
PARSHALL B LYNNE	COO & Secretary	M Exercise	2015-04-07	2015-04-08	5,565	$14.69	$81.7K	13,637	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise deriv	2015-04-01	2015-04-06	1,966	—	$0	9,384	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise deriv	2015-04-01	2015-04-06	19,657	—	$0	49,506	SEC↗
PARSHALL B LYNNE	COO & Secretary	M Exercise deriv	2015-04-01	2015-04-06	5,377	—	$0	43,193	SEC↗
CROOKE STANLEY T	Chairman and CEO	S Sale	2015-04-01	2015-04-06	1,966	$61.93	$121.8K	1,297	SEC↗
CROOKE STANLEY T	Chairman and CEO	S Sale	2015-04-01	2015-04-06	19,657	$61.93	$1.22M	14,642	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise	2015-04-01	2015-04-06	19,657	$11.27	$221.5K	34,299	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise	2015-04-01	2015-04-06	1,966	$9.22	$18.1K	3,263	SEC↗
PARSHALL B LYNNE	COO & Secretary	M Exercise	2015-04-01	2015-04-06	5,377	$14.69	$79.0K	13,449	SEC↗
PARSHALL B LYNNE	COO & Secretary	S Sale	2015-04-01	2015-04-06	5,377	$61.93	$333.0K	8,072	SEC↗
BENNETT C FRANK	SVP, Antisense Research	M Exercise deriv	2015-03-24	2015-03-25	9,000	—	$0	17,909	SEC↗
BENNETT C FRANK	SVP, Antisense Research	M Exercise	2015-03-24	2015-03-25	9,000	$14.47	$130.2K	16,229	SEC↗
BENNETT C FRANK	SVP, Antisense Research	S Sale	2015-03-24	2015-03-25	9,000	$71.01	$639.1K	7,229	SEC↗
BENNETT C FRANK	SVP, Antisense Research	M Exercise deriv	2015-03-23	2015-03-25	6,000	—	$0	26,909	SEC↗
BENNETT C FRANK	SVP, Antisense Research	M Exercise	2015-03-23	2015-03-25	1,000	$14.47	$14.5K	8,229	SEC↗
BENNETT C FRANK	SVP, Antisense Research	S Sale	2015-03-23	2015-03-25	1,000	$71.00	$71.0K	7,229	SEC↗
BENNETT C FRANK	SVP, Antisense Research	S Sale	2015-03-23	2015-03-25	5,000	$69.80	$349.0K	7,229	SEC↗
BENNETT C FRANK	SVP, Antisense Research	M Exercise	2015-03-23	2015-03-25	5,000	$14.47	$72.3K	12,229	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	M Exercise deriv	2015-03-19	2015-03-20	4,000	—	$0	3,500	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	M Exercise deriv	2015-03-19	2015-03-20	1,617	—	$0	0	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	M Exercise deriv	2015-03-19	2015-03-20	5,683	—	$0	4,067	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	M Exercise deriv	2015-03-19	2015-03-20	13,125	—	$0	31,875	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	M Exercise deriv	2015-03-19	2015-03-20	6,100	—	$0	7,253	SEC↗
Geary Richard S	SVP, Development	M Exercise deriv	2015-03-19	2015-03-20	8,000	—	$0	17,240	SEC↗
HOUGEN ELIZABETH L	SVP, Finance & CFO	M Exercise deriv	2015-03-19	2015-03-20	10,000	—	$0	10,000	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	M Exercise	2015-03-19	2015-03-20	5,683	$7.25	$41.2K	11,857	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	S Sale	2015-03-19	2015-03-20	1,617	$74.77	$120.9K	6,174	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	M Exercise	2015-03-19	2015-03-20	1,617	$10.29	$16.6K	7,791	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	S Sale	2015-03-19	2015-03-20	10,525	$75.00	$789.4K	6,174	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	M Exercise	2015-03-19	2015-03-20	10,525	$39.87	$419.6K	16,699	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	S Sale	2015-03-19	2015-03-20	5,683	$74.77	$424.9K	6,174	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	M Exercise	2015-03-19	2015-03-20	6,100	$10.82	$66.0K	12,274	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	S Sale	2015-03-19	2015-03-20	6,100	$74.77	$456.1K	6,174	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	M Exercise	2015-03-19	2015-03-20	4,000	$10.82	$43.3K	10,174	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	S Sale	2015-03-19	2015-03-20	4,000	$74.77	$299.1K	6,174	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	S Sale	2015-03-19	2015-03-20	2,600	$74.77	$194.4K	6,174	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	M Exercise	2015-03-19	2015-03-20	2,600	$39.87	$103.7K	8,774	SEC↗
Geary Richard S	SVP, Development	S Sale	2015-03-19	2015-03-20	8,000	$75.00	$600.0K	4,555	SEC↗
Geary Richard S	SVP, Development	M Exercise	2015-03-19	2015-03-20	8,000	$14.69	$117.5K	12,555	SEC↗
HOUGEN ELIZABETH L	SVP, Finance & CFO	S Sale	2015-03-19	2015-03-20	10,000	$73.33	$733.3K	3,387	SEC↗
HOUGEN ELIZABETH L	SVP, Finance & CFO	M Exercise	2015-03-19	2015-03-20	10,000	$11.27	$112.7K	13,387	SEC↗
WENDER JOSEPH H	Director	M Exercise deriv	2015-03-18	2015-03-20	12,500	—	$0	0	SEC↗
WENDER JOSEPH H	Director	M Exercise	2015-03-18	2015-03-20	6,100	$5.93	$36.2K	36,317	SEC↗
WENDER JOSEPH H	Director	S Sale	2015-03-18	2015-03-20	6,100	$70.95	$432.8K	30,217	SEC↗
WENDER JOSEPH H	Director	M Exercise	2015-03-18	2015-03-20	6,400	$5.93	$38.0K	36,617	SEC↗
WENDER JOSEPH H	Director	S Sale	2015-03-18	2015-03-20	6,400	$71.84	$459.8K	30,217	SEC↗
KLEIN JOSEPH III	Director	M Exercise deriv	2015-03-05	2015-03-09	3,750	—	$0	3,750	SEC↗
KLEIN JOSEPH III	Director	M Exercise deriv	2015-03-05	2015-03-09	2,500	—	$0	5,937	SEC↗
KLEIN JOSEPH III	Director	M Exercise deriv	2015-03-05	2015-03-09	3,750	—	$0	0	SEC↗
WENDER JOSEPH H	Director	M Exercise deriv	2015-03-05	2015-03-09	12,500	—	$0	0	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	M Exercise deriv	2015-03-05	2015-03-09	1,667	—	$0	0	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	M Exercise deriv	2015-03-05	2015-03-09	4,133	—	$0	1,617	SEC↗
HOUGEN ELIZABETH L	SVP, Finance & CFO	M Exercise deriv	2015-03-05	2015-03-09	15,437	—	$0	4,063	SEC↗
HOUGEN ELIZABETH L	SVP, Finance & CFO	M Exercise deriv	2015-03-05	2015-03-09	12,657	—	$0	0	SEC↗
Geary Richard S	SVP, Development	M Exercise deriv	2015-03-05	2015-03-09	80	—	$0	0	SEC↗
Geary Richard S	SVP, Development	M Exercise deriv	2015-03-05	2015-03-09	8,000	—	$0	426	SEC↗
Geary Richard S	SVP, Development	M Exercise deriv	2015-03-05	2015-03-09	7,000	—	$0	7,035	SEC↗
KLEIN JOSEPH III	Director	M Exercise	2015-03-05	2015-03-09	3,750	$9.30	$34.9K	8,595	SEC↗
KLEIN JOSEPH III	Director	M Exercise	2015-03-05	2015-03-09	2,500	$12.94	$32.4K	11,095	SEC↗
KLEIN JOSEPH III	Director	S Sale	2015-03-05	2015-03-09	7,000	$70.95	$496.6K	4,095	SEC↗
KLEIN JOSEPH III	Director	M Exercise	2015-03-05	2015-03-09	3,750	$9.22	$34.6K	4,845	SEC↗
WENDER JOSEPH H	Director	M Exercise	2015-03-05	2015-03-09	12,500	$9.77	$122.1K	42,717	SEC↗
WENDER JOSEPH H	Director	S Sale	2015-03-05	2015-03-09	12,500	$71.61	$895.1K	30,217	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	S Sale	2015-03-05	2015-03-09	4,133	$71.67	$296.2K	6,174	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	M Exercise	2015-03-05	2015-03-09	4,133	$10.29	$42.5K	10,307	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	S Sale	2015-03-05	2015-03-09	1,667	$71.67	$119.5K	6,174	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	M Exercise	2015-03-05	2015-03-09	1,667	$8.00	$13.3K	7,841	SEC↗
HOUGEN ELIZABETH L	SVP, Finance & CFO	S Sale	2015-03-05	2015-03-09	8,000	$71.67	$573.4K	3,387	SEC↗
HOUGEN ELIZABETH L	SVP, Finance & CFO	M Exercise	2015-03-05	2015-03-09	8,000	$7.25	$58.0K	11,387	SEC↗
HOUGEN ELIZABETH L	SVP, Finance & CFO	S Sale	2015-03-05	2015-03-09	12,657	$71.67	$907.1K	3,387	SEC↗
HOUGEN ELIZABETH L	SVP, Finance & CFO	M Exercise	2015-03-05	2015-03-09	12,657	$14.47	$183.1K	16,044	SEC↗
HOUGEN ELIZABETH L	SVP, Finance & CFO	M Exercise	2015-03-05	2015-03-09	7,437	$7.25	$53.9K	10,824	SEC↗
HOUGEN ELIZABETH L	SVP, Finance & CFO	S Sale	2015-03-05	2015-03-09	7,437	$71.32	$530.4K	3,387	SEC↗
Geary Richard S	SVP, Development	S Sale	2015-03-05	2015-03-09	3,015	$71.67	$216.1K	4,555	SEC↗
Geary Richard S	SVP, Development	S Sale	2015-03-05	2015-03-09	8,000	$71.67	$573.4K	4,555	SEC↗
Geary Richard S	SVP, Development	M Exercise	2015-03-05	2015-03-09	7,000	$7.25	$50.8K	11,555	SEC↗
Geary Richard S	SVP, Development	S Sale	2015-03-05	2015-03-09	7,000	$70.32	$492.2K	4,555	SEC↗
Geary Richard S	SVP, Development	M Exercise	2015-03-05	2015-03-09	8,000	$10.29	$82.3K	12,555	SEC↗
Geary Richard S	SVP, Development	S Sale	2015-03-05	2015-03-09	80	$71.67	$5.7K	4,555	SEC↗
Geary Richard S	SVP, Development	M Exercise	2015-03-05	2015-03-09	80	$11.27	$902	4,635	SEC↗
WENDER JOSEPH H	Director	S Sale	2015-03-02	2015-03-04	7,000	$65.97	$461.8K	30,217	SEC↗
WENDER JOSEPH H	Director	M Exercise deriv	2015-02-12	2015-02-17	10,000	—	$0	0	SEC↗
WENDER JOSEPH H	Director	S Sale	2015-02-12	2015-02-17	10,000	$62.15	$621.5K	37,217	SEC↗
WENDER JOSEPH H	Director	M Exercise	2015-02-12	2015-02-17	10,000	$3.95	$39.5K	47,217	SEC↗
KLEIN JOSEPH III	Director	G Gift	2015-02-11	2015-02-13	2,000	—	$0	1,095	SEC↗
LOSCALZO JOSEPH	Director	M Exercise deriv	2015-02-03	2015-02-05	938	—	$0	2,812	SEC↗
LOSCALZO JOSEPH	Director	M Exercise	2015-02-03	2015-02-05	938	—	$0	938	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise deriv	2015-01-27	2015-01-29	10,000	—	$0	69,163	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise deriv	2015-01-27	2015-01-29	1,000	—	$0	11,350	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise	2015-01-27	2015-01-29	1,000	$9.22	$9.2K	2,297	SEC↗
CROOKE STANLEY T	Chairman and CEO	S Sale	2015-01-27	2015-01-29	1,000	$72.93	$72.9K	1,297	SEC↗
CROOKE STANLEY T	Chairman and CEO	S Sale	2015-01-27	2015-01-29	10,000	$72.93	$729.3K	14,642	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise	2015-01-27	2015-01-29	10,000	$11.27	$112.7K	24,642	SEC↗
Geary Richard S	SVP, Development	S Sale	2015-01-16	2015-01-20	533	$67.96	$36.2K	6,409	SEC↗
Geary Richard S	SVP, Development	S Sale	2015-01-16	2015-01-20	714	$67.96	$48.5K	7,570	SEC↗
Geary Richard S	SVP, Development	S Sale	2015-01-16	2015-01-20	296	$67.96	$20.1K	5,544	SEC↗
BENNETT C FRANK	SVP, Antisense Research	S Sale	2015-01-16	2015-01-20	539	$67.96	$36.6K	6,068	SEC↗
BENNETT C FRANK	SVP, Antisense Research	S Sale	2015-01-16	2015-01-20	714	$67.96	$48.5K	7,229	SEC↗
BENNETT C FRANK	SVP, Antisense Research	S Sale	2015-01-16	2015-01-20	265	$67.96	$18.0K	5,192	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	S Sale	2015-01-16	2015-01-20	120	$67.96	$8.2K	4,609	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	S Sale	2015-01-16	2015-01-20	207	$67.96	$14.1K	4,416	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	S Sale	2015-01-16	2015-01-20	714	$67.96	$48.5K	6,174	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	S Sale	2015-01-16	2015-01-20	250	$67.96	$17.0K	5,013	SEC↗
HOUGEN ELIZABETH L	SVP, Finance & CFO	S Sale	2015-01-16	2015-01-20	120	$67.96	$8.2K	1,822	SEC↗
HOUGEN ELIZABETH L	SVP, Finance & CFO	S Sale	2015-01-16	2015-01-20	714	$67.96	$48.5K	3,387	SEC↗
HOUGEN ELIZABETH L	SVP, Finance & CFO	S Sale	2015-01-16	2015-01-20	250	$67.96	$17.0K	2,226	SEC↗
HOUGEN ELIZABETH L	SVP, Finance & CFO	S Sale	2015-01-16	2015-01-20	207	$67.96	$14.1K	1,629	SEC↗
Monia Brett P	SVP, Antisense Drug Discover	S Sale	2015-01-16	2015-01-20	714	$67.96	$48.5K	4,426	SEC↗
Monia Brett P	SVP, Antisense Drug Discover	S Sale	2015-01-16	2015-01-20	539	$67.96	$36.6K	3,265	SEC↗
Monia Brett P	SVP, Antisense Drug Discover	S Sale	2015-01-16	2015-01-20	80	$67.96	$5.4K	2,389	SEC↗
Monia Brett P	SVP, Antisense Drug Discover	S Sale	2015-01-16	2015-01-20	201	$67.96	$13.7K	2,261	SEC↗
PARSHALL B LYNNE	COO & Secretary	S Sale	2015-01-16	2015-01-20	1,372	$67.96	$93.2K	6,452	SEC↗
PARSHALL B LYNNE	COO & Secretary	S Sale	2015-01-16	2015-01-20	1,818	$67.96	$123.6K	8,072	SEC↗
PARSHALL B LYNNE	COO & Secretary	S Sale	2015-01-16	2015-01-20	903	$67.96	$61.4K	5,229	SEC↗
CROOKE STANLEY T	Chairman and CEO	S Sale	2015-01-16	2015-01-20	1,574	$67.96	$107.0K	8,344	SEC↗
CROOKE STANLEY T	Chairman and CEO	S Sale	2015-01-16	2015-01-20	2,933	$67.96	$199.3K	10,959	SEC↗
CROOKE STANLEY T	Chairman and CEO	S Sale	2015-01-16	2015-01-20	4,130	$67.96	$280.7K	14,642	SEC↗
CROOKE STANLEY T	Chairman and CEO	S Sale	2015-01-16	2015-01-20	121	$67.96	$8.2K	822	SEC↗
CROOKE STANLEY T	Chairman and CEO	S Sale	2015-01-16	2015-01-20	160	$67.96	$10.9K	1,079	SEC↗
CROOKE STANLEY T	Chairman and CEO	S Sale	2015-01-16	2015-01-20	136	$67.96	$9.2K	1,297	SEC↗
Geary Richard S	SVP, Development	A Award deriv	2015-01-15	2015-01-20	5,518	—	$0	5,518	SEC↗
Geary Richard S	SVP, Development	M Exercise deriv	2015-01-15	2015-01-20	776	—	$0	775	SEC↗
Geary Richard S	SVP, Development	M Exercise deriv	2015-01-15	2015-01-20	1,875	—	$0	5,625	SEC↗
Geary Richard S	SVP, Development	M Exercise deriv	2015-01-15	2015-01-20	1,398	—	$0	2,794	SEC↗
BENNETT C FRANK	SVP, Antisense Research	M Exercise deriv	2015-01-15	2015-01-20	694	—	$0	694	SEC↗
BENNETT C FRANK	SVP, Antisense Research	M Exercise deriv	2015-01-15	2015-01-20	1,415	—	$0	2,830	SEC↗
BENNETT C FRANK	SVP, Antisense Research	M Exercise deriv	2015-01-15	2015-01-20	1,875	—	$0	5,625	SEC↗
BENNETT C FRANK	SVP, Antisense Research	A Award deriv	2015-01-15	2015-01-20	5,242	—	$0	5,242	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	M Exercise deriv	2015-01-15	2015-01-20	1,875	—	$0	5,625	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	A Award deriv	2015-01-15	2015-01-20	5,242	—	$0	5,242	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	M Exercise deriv	2015-01-15	2015-01-20	654	—	$0	1,307	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	M Exercise deriv	2015-01-15	2015-01-20	313	—	$0	624	SEC↗
O'NEIL PATRICK R.	SVP, Legal & General Counsel	M Exercise deriv	2015-01-15	2015-01-20	541	—	$0	541	SEC↗
HOUGEN ELIZABETH L	SVP, Finance & CFO	M Exercise deriv	2015-01-15	2015-01-20	654	—	$0	1,307	SEC↗
HOUGEN ELIZABETH L	SVP, Finance & CFO	M Exercise deriv	2015-01-15	2015-01-20	313	—	$0	624	SEC↗
HOUGEN ELIZABETH L	SVP, Finance & CFO	A Award deriv	2015-01-15	2015-01-20	5,518	—	$0	5,518	SEC↗
HOUGEN ELIZABETH L	SVP, Finance & CFO	M Exercise deriv	2015-01-15	2015-01-20	541	—	$0	541	SEC↗
HOUGEN ELIZABETH L	SVP, Finance & CFO	M Exercise deriv	2015-01-15	2015-01-20	1,875	—	$0	5,625	SEC↗
Monia Brett P	SVP, Antisense Drug Discover	A Award deriv	2015-01-15	2015-01-20	6,070	—	$0	6,070	SEC↗
Monia Brett P	SVP, Antisense Drug Discover	M Exercise deriv	2015-01-15	2015-01-20	527	—	$0	527	SEC↗
Monia Brett P	SVP, Antisense Drug Discover	M Exercise deriv	2015-01-15	2015-01-20	1,875	—	$0	5,625	SEC↗
Monia Brett P	SVP, Antisense Drug Discover	M Exercise deriv	2015-01-15	2015-01-20	1,415	—	$0	2,830	SEC↗
Monia Brett P	SVP, Antisense Drug Discover	M Exercise deriv	2015-01-15	2015-01-20	208	—	$0	208	SEC↗
PARSHALL B LYNNE	COO & Secretary	M Exercise deriv	2015-01-15	2015-01-20	3,438	—	$0	10,312	SEC↗
PARSHALL B LYNNE	COO & Secretary	A Award deriv	2015-01-15	2015-01-20	22,076	—	$0	22,076	SEC↗
PARSHALL B LYNNE	COO & Secretary	M Exercise deriv	2015-01-15	2015-01-20	1,715	—	$0	1,715	SEC↗
PARSHALL B LYNNE	COO & Secretary	M Exercise deriv	2015-01-15	2015-01-20	2,595	—	$0	5,190	SEC↗
Boyce Sarah	Chief Business Officer	A Award deriv	2015-01-15	2015-01-20	8,750	—	$0	8,750	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise deriv	2015-01-15	2015-01-20	2,977	—	$0	2,977	SEC↗
CROOKE STANLEY T	Chairman and CEO	M Exercise deriv	2015-01-15	2015-01-20	417	—	$0	832	SEC↗