KYMR

Kymera Therapeutics, Inc.CIK 1815442 ☆ Sign in to watch Congress trades

Open-mkt buys · 90d

—

0 trades · 0 insiders

Open-mkt sales · 90d

$4.90M

12 trades · 2 insiders

Net · 90d

$-4.90M

Insiders on file

AI insights for KYMR PRO

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AI insights for KYMR

Insider sentiment score with a plain-English explanation, conviction score on every buy, and how the stock performed 30 and 90 days after past insider buys.

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Daily buy vs sell · 90 days

■ Open-market buys (P) ■ Open-market sales (S) · daily dollar value by transaction date

Insiders

Insider	Role	Trades	Bought	Sold	Last trade
Mainolfi Nello	President and CEO	198	$0	$55.37M	2026-10-01
Adams Brian	Chief Legal Officer	10	$0	$1.49M	2026-09-04
Rooney Terence	Chief Medical Officer	2	$0	$0	2026-07-27
Goodman Noah	Chief Business Officer	19	$0	$2.22M	2026-07-01
Jacobs Bruce N.	Chief Financial Officer	98	$0	$18.73M	2026-06-30
Booth Bruce	Director	253	$0	$323.25M	2026-06-29
BIOTECHNOLOGY VALUE FUND II LP	Director	13	$30.04M	$173.67M	2026-06-26
Hrustanovic Gorjan	Director	7	$0	$0	2026-06-24
Ridloff Elena	Director	27	$0	$2.06M	2026-06-24
Esposito Pamela	Director	47	$0	$4.07M	2026-06-24
Biotechnology Value Trading Fund OS LP	Other	7	$24.26M	$0	2026-06-24
Albers Jeffrey W.	Director	29	$0	$1.80M	2026-06-24
Sandor Victor	Director	5	$0	$0	2026-06-24
Baker Bros. Advisors (GP) LLC	Director, 10% Owner	6	$57.68M	$0	2026-06-24
MARAGANORE JOHN	Director	5	$0	$0	2026-06-24
Chadwick Jeremy G	Chief Operating Officer	61	$0	$15.81M	2026-05-27
Gollob Jared	Chief Medical Officer	90	$0	$20.60M	2026-03-04
BAKER FELIX	Director, 10% Owner	2	$172.50M	$0	2025-12-11
BAKER BROS. ADVISORS LP	Director	4	$0	$0	2025-06-25
Chiniara Ellen	Chief Legal Officer	10	$0	$273.3K	2025-03-03
667, L.P.	Director	3	$105.71M	$0	2024-08-21
BIOTECHNOLOGY VALUE FUND L P	Other	7	$25.72M	$0	2024-06-18
Morgan Leigh	Director	3	$0	$0	2024-06-18
Horobin Joanna	Director	8	$0	$280.4K	2024-06-07
Atlas Venture Associates Opportunity I, LLC	10% Owner	24	$0	$26.90M	2024-03-13
BVF I GP LLC	Director	3	$24.72M	$0	2024-01-05
BVF II GP LLC	Director	6	$5.30M	$0	2023-11-03
LAMPERT MARK N	Other	11	$0	$0	2023-06-15
Caughey Elaine	Chief Business Officer	7	$0	$22.1K	2023-03-02
Atlas Venture Opportunity Fund I, L.P.	10% Owner	4	$0	$3.82M	2023-01-12
Atlas Venture Associates Opportunity I, L.P.	10% Owner	4	$0	$6.60M	2022-11-03
Atlas Venture Fund X, L.P.	10% Owner	16	$0	$8.74M	2022-11-01
Nicholson Donald William	Director	3	$0	$0	2022-06-15
BVF INC/IL	Other	11	$9.94M	$0	2022-06-15
BVF PARTNERS L P/IL	Director	7	$4.15M	$0	2022-05-27
Chesworth Richard	Chief Scientific Officer	11	$0	$4.75M	2021-08-27
Atlas Venture Associates X, LLC	10% Owner	2	$0	$27.73M	2021-08-11
Hall Steven Edward	Director	5	$0	$0	2021-06-16
Wellington Biomedical Innovation Master Investors (Cayman) I L.P.	10% Owner	2	$0	$0	2020-08-25
Alexandria Venture Investments, LLC	10% Owner	3	$0	$0	2020-08-25
Redmile Group, LLC	10% Owner	2	$0	$0	2020-08-25
Hedin Andrew	Director	1	$0	$0	2020-08-20

Trade history

Insider	Role	Code	Trade	Filed	Shares	Price	Value	Owned after
Mainolfi Nello	Chief Executive Officer, Dir	M Exercise deriv	2026-10-01	2026-10-01	30,000	—	$0	60,000	SEC↗
Mainolfi Nello	Chief Executive Officer, Dir	S Sale	2026-10-01	2026-10-01	262	$116.12	$30.4K	666,568	SEC↗
Mainolfi Nello	Chief Executive Officer, Dir	S Sale	2026-10-01	2026-10-01	8,230	$115.40	$949.7K	666,830	SEC↗
Mainolfi Nello	Chief Executive Officer, Dir	S Sale	2026-10-01	2026-10-01	7,601	$114.43	$869.8K	675,060	SEC↗
Mainolfi Nello	Chief Executive Officer, Dir	S Sale	2026-10-01	2026-10-01	4,876	$113.24	$552.2K	682,661	SEC↗
Mainolfi Nello	Chief Executive Officer, Dir	S Sale	2026-10-01	2026-10-01	5,506	$112.42	$619.0K	687,537	SEC↗
Mainolfi Nello	Chief Executive Officer, Dir	S Sale	2026-10-01	2026-10-01	3,525	$111.44	$392.8K	693,043	SEC↗
Mainolfi Nello	Chief Executive Officer, Dir	M Exercise	2026-10-01	2026-10-01	30,000	$2.08	$62.4K	696,568	SEC↗
Adams Brian	Chief Legal Officer	S Sale	2026-09-04	2026-09-04	2,137	$117.57	$251.2K	50,254	SEC↗
Adams Brian	Chief Legal Officer	S Sale	2026-09-04	2026-09-04	3,025	$116.81	$353.4K	52,391	SEC↗
Adams Brian	Chief Legal Officer	S Sale	2026-09-04	2026-09-04	1,209	$115.55	$139.7K	55,416	SEC↗
Adams Brian	Chief Legal Officer	S Sale	2026-09-04	2026-09-04	2,137	$117.57	$251.2K	50,254	SEC↗
Adams Brian	Chief Legal Officer	S Sale	2026-09-04	2026-09-04	3,025	$116.81	$353.4K	52,391	SEC↗
Adams Brian	Chief Legal Officer	S Sale	2026-09-04	2026-09-04	1,209	$115.55	$139.7K	55,416	SEC↗
Rooney Terence	Chief Medical Officer	A Award deriv	2026-07-27	2026-07-27	76,000	—	$0	76,000	SEC↗
Rooney Terence	Chief Medical Officer	A Award	2026-07-27	2026-07-27	38,000	—	$0	38,000	SEC↗
Mainolfi Nello	Chief Executive Officer	M Exercise deriv	2026-07-07	2026-07-07	45,559	—	$0	90,000	SEC↗
Mainolfi Nello	Chief Executive Officer	M Exercise deriv	2026-07-07	2026-07-07	4,441	—	$0	14,284	SEC↗
Mainolfi Nello	Chief Executive Officer	S Sale	2026-07-07	2026-07-07	50,000	$119.00	$5.95M	666,568	SEC↗
Mainolfi Nello	Chief Executive Officer	M Exercise	2026-07-07	2026-07-07	50,000	$2.08	$104.0K	716,568	SEC↗
Mainolfi Nello	Chief Executive Officer	M Exercise deriv	2026-07-01	2026-07-02	80,000	—	$0	135,559	SEC↗
Mainolfi Nello	Chief Executive Officer	S Sale	2026-07-01	2026-07-02	3,336	$116.56	$388.8K	666,568	SEC↗
Mainolfi Nello	Chief Executive Officer	S Sale	2026-07-01	2026-07-02	24,105	$114.96	$2.77M	713,954	SEC↗
Mainolfi Nello	Chief Executive Officer	S Sale	2026-07-01	2026-07-02	44,050	$115.69	$5.10M	669,904	SEC↗
Mainolfi Nello	Chief Executive Officer	S Sale	2026-07-01	2026-07-02	6,626	$113.98	$755.2K	738,059	SEC↗
Mainolfi Nello	Chief Executive Officer	S Sale	2026-07-01	2026-07-02	1,883	$112.80	$212.4K	744,685	SEC↗
Mainolfi Nello	Chief Executive Officer	M Exercise	2026-07-01	2026-07-02	80,000	$2.08	$166.4K	746,568	SEC↗
Goodman Noah	Chief Business Officer	S Sale	2026-07-01	2026-07-02	3,389	$114.29	$387.3K	47,179	SEC↗
Jacobs Bruce N.	Chief Financial Officer	M Exercise deriv	2026-06-30	2026-07-02	61,378	—	$0	0	SEC↗
Jacobs Bruce N.	Chief Financial Officer	S Sale	2026-06-30	2026-07-02	6,153	$116.99	$719.8K	248,083	SEC↗
Jacobs Bruce N.	Chief Financial Officer	S Sale	2026-06-30	2026-07-02	3,200	$117.70	$376.6K	244,883	SEC↗
Jacobs Bruce N.	Chief Financial Officer	S Sale	2026-06-30	2026-07-02	7,971	$115.82	$923.2K	254,236	SEC↗
Jacobs Bruce N.	Chief Financial Officer	M Exercise	2026-06-30	2026-07-02	61,378	$5.33	$327.1K	321,992	SEC↗
Jacobs Bruce N.	Chief Financial Officer	S Sale	2026-06-30	2026-07-02	1,500	$110.54	$165.8K	320,492	SEC↗
Jacobs Bruce N.	Chief Financial Officer	S Sale	2026-06-30	2026-07-02	1,700	$111.57	$189.7K	318,792	SEC↗
Jacobs Bruce N.	Chief Financial Officer	S Sale	2026-06-30	2026-07-02	51,375	$114.77	$5.90M	262,207	SEC↗
Jacobs Bruce N.	Chief Financial Officer	S Sale	2026-06-30	2026-07-02	4,110	$114.19	$469.3K	313,582	SEC↗
Jacobs Bruce N.	Chief Financial Officer	S Sale	2026-06-30	2026-07-02	1,100	$112.79	$124.1K	317,692	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-07-02	934	$111.20	$103.9K	2,384,685	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-07-02	5,549	$105.78	$587.0K	2,446,375	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-07-02	14,798	$106.63	$1.58M	2,431,577	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-07-02	19,419	$107.76	$2.09M	2,412,158	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-07-02	130	$111.20	$14.5K	462,856	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-07-02	1,078	$110.67	$119.3K	462,986	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-07-02	1,104	$109.75	$121.2K	464,064	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-07-02	1,498	$108.28	$162.2K	465,168	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-07-02	2,698	$107.76	$290.7K	466,666	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-07-02	2,133	$106.63	$227.4K	469,364	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-07-02	770	$105.78	$81.5K	471,497	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-07-02	7,723	$110.67	$854.7K	2,385,619	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-07-02	7,968	$109.75	$874.5K	2,393,342	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-07-02	10,848	$108.28	$1.17M	2,401,310	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-06-30	3,024	$107.76	$325.9K	466,077	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-06-30	2,318	$106.63	$247.2K	469,101	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-06-30	848	$105.78	$89.7K	471,419	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-06-30	19,093	$107.76	$2.06M	2,412,747	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-06-30	14,613	$106.63	$1.56M	2,431,840	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-06-30	5,471	$105.78	$578.7K	2,446,453	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-06-30	1,239	$109.75	$136.0K	463,150	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-06-30	1,688	$108.28	$182.8K	464,389	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-06-30	907	$111.20	$100.9K	2,385,747	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-06-30	7,602	$110.67	$841.3K	2,386,654	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-06-30	1,199	$110.67	$132.7K	461,951	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-06-30	157	$111.20	$17.5K	461,794	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-06-30	7,833	$109.75	$859.7K	2,394,256	SEC↗
Booth Bruce	Director	S Sale	2026-06-29	2026-06-30	10,658	$108.28	$1.15M	2,402,089	SEC↗
BIOTECHNOLOGY VALUE FUND II LP	Director	S Sale	2026-06-26	2026-06-26	627,597	$106.50	$66.84M	1,592,261	SEC↗
BIOTECHNOLOGY VALUE FUND II LP	Director	S Sale	2026-06-26	2026-06-26	113,289	$106.50	$12.07M	240,123	SEC↗
BIOTECHNOLOGY VALUE FUND II LP	Director	S Sale	2026-06-26	2026-06-26	51,858	$106.50	$5.52M	78,787	SEC↗
BIOTECHNOLOGY VALUE FUND II LP	Director	S Sale	2026-06-26	2026-06-26	837,914	$106.50	$89.24M	1,960,881	SEC↗
Booth Bruce	Director	S Sale	2026-06-26	2026-06-30	1,729	$118.66	$205.2K	472,267	SEC↗
Booth Bruce	Director	S Sale	2026-06-26	2026-06-30	3,069	$117.85	$361.7K	473,996	SEC↗
Booth Bruce	Director	S Sale	2026-06-26	2026-06-30	1,701	$117.09	$199.2K	477,065	SEC↗
Booth Bruce	Director	S Sale	2026-06-26	2026-06-30	952	$115.69	$110.1K	478,766	SEC↗
Booth Bruce	Director	S Sale	2026-06-26	2026-06-30	3,896	$114.94	$447.8K	479,718	SEC↗
Booth Bruce	Director	S Sale	2026-06-26	2026-06-30	2,083	$113.97	$237.4K	483,614	SEC↗
Booth Bruce	Director	S Sale	2026-06-26	2026-06-30	78	$112.49	$8.8K	485,697	SEC↗
Booth Bruce	Director	S Sale	2026-06-26	2026-06-30	1,442	$111.51	$160.8K	485,775	SEC↗
Booth Bruce	Director	S Sale	2026-06-26	2026-06-30	1,579	$110.49	$174.5K	487,217	SEC↗
Booth Bruce	Director	S Sale	2026-06-26	2026-06-30	4,562	$109.79	$500.9K	488,796	SEC↗
Booth Bruce	Director	S Sale	2026-06-26	2026-06-30	32,402	$108.14	$3.50M	493,358	SEC↗
Booth Bruce	Director	S Sale	2026-06-26	2026-06-30	3,958	$107.57	$425.8K	525,760	SEC↗
Booth Bruce	Director	S Sale	2026-06-26	2026-06-30	12,390	$118.66	$1.47M	2,451,924	SEC↗
Booth Bruce	Director	S Sale	2026-06-26	2026-06-30	22,046	$117.85	$2.60M	2,464,314	SEC↗
Booth Bruce	Director	S Sale	2026-06-26	2026-06-30	12,181	$117.09	$1.43M	2,486,360	SEC↗
Booth Bruce	Director	S Sale	2026-06-26	2026-06-30	6,821	$115.69	$789.1K	2,498,541	SEC↗
Booth Bruce	Director	S Sale	2026-06-26	2026-06-30	27,951	$114.94	$3.21M	2,505,362	SEC↗
Booth Bruce	Director	S Sale	2026-06-26	2026-06-30	14,913	$113.97	$1.70M	2,533,313	SEC↗
Booth Bruce	Director	S Sale	2026-06-26	2026-06-30	555	$112.49	$62.4K	2,548,226	SEC↗
Booth Bruce	Director	S Sale	2026-06-26	2026-06-30	10,366	$111.51	$1.16M	2,548,781	SEC↗
Booth Bruce	Director	S Sale	2026-06-26	2026-06-30	11,277	$110.49	$1.25M	2,559,147	SEC↗
Booth Bruce	Director	S Sale	2026-06-26	2026-06-30	32,624	$109.79	$3.58M	2,570,424	SEC↗
Booth Bruce	Director	S Sale	2026-06-26	2026-06-30	231,007	$108.14	$24.98M	2,603,048	SEC↗
Booth Bruce	Director	S Sale	2026-06-26	2026-06-30	28,296	$107.57	$3.04M	2,834,055	SEC↗
Goodman Noah	Chief Business Officer	M Exercise deriv	2026-06-25	2026-06-25	5,000	—	$0	90,000	SEC↗
Goodman Noah	Chief Business Officer	M Exercise	2026-06-25	2026-06-25	5,000	$21.05	$105.3K	55,195	SEC↗
Goodman Noah	Chief Business Officer	S Sale	2026-06-25	2026-06-25	2,500	$109.00	$272.5K	52,695	SEC↗
Goodman Noah	Chief Business Officer	S Sale	2026-06-25	2026-06-25	2,500	$119.00	$297.5K	50,195	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	159	$108.02	$17.2K	3,333,190	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	9,994	$107.30	$1.07M	3,333,349	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	2,646	$118.60	$313.8K	564,668	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	3,359	$117.50	$394.7K	567,314	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	11,375	$116.53	$1.33M	570,673	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	8,389	$115.57	$969.5K	582,048	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	1,289	$114.65	$147.8K	590,437	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	1,437	$113.70	$163.4K	591,726	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	100	$111.89	$11.2K	593,163	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	14,351	$108.83	$1.56M	3,318,839	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	1,915	$110.30	$211.2K	3,316,924	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	614	$110.79	$68.0K	3,316,310	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	719	$111.89	$80.4K	3,315,591	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	10,215	$113.70	$1.16M	3,305,376	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	9,229	$114.65	$1.06M	3,296,147	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	58,205	$115.57	$6.73M	3,237,942	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	81,500	$116.53	$9.50M	3,156,442	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	24,268	$117.50	$2.85M	3,132,174	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	19,089	$118.60	$2.26M	3,113,085	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	1,399	$107.30	$150.1K	595,648	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	23	$108.02	$2.5K	595,625	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	2,011	$108.83	$218.9K	593,614	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	86	$110.79	$9.5K	593,263	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	265	$110.30	$29.2K	593,349	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	3,507	$127.37	$446.7K	530,069	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	223	$126.71	$28.3K	533,576	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	522	$125.82	$65.7K	533,799	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	1,639	$124.61	$204.2K	534,321	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	1,517	$123.62	$187.5K	535,960	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	698	$122.67	$85.6K	537,477	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	5,689	$121.38	$690.5K	538,175	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	15,660	$120.66	$1.89M	543,864	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	5,144	$119.71	$615.8K	559,524	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	337	$129.61	$43.7K	2,862,351	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	2,197	$128.69	$282.7K	2,862,688	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	25,075	$127.37	$3.19M	2,864,885	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	1,609	$126.71	$203.9K	2,889,960	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	3,716	$125.82	$467.5K	2,891,569	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	11,711	$124.61	$1.46M	2,895,285	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	10,860	$123.62	$1.34M	2,906,996	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	4,977	$122.67	$610.5K	2,917,856	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	40,774	$121.38	$4.95M	2,922,833	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	112,299	$120.66	$13.55M	2,963,607	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	37,179	$119.71	$4.45M	3,075,906	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	46	$129.61	$6.0K	529,718	SEC↗
Booth Bruce	Director	S Sale	2026-06-25	2026-06-25	305	$128.69	$39.3K	529,764	SEC↗
Baker Bros. Advisors (GP) LLC	Director, 10% Owner	A Award deriv	2026-06-24	2026-06-25	6,068	—	$0	6,068	SEC↗
Baker Bros. Advisors (GP) LLC	Director, 10% Owner	A Award deriv	2026-06-24	2026-06-25	6,068	—	$0	6,068	SEC↗
Esposito Pamela	Director	A Award deriv	2026-06-24	2026-06-25	6,068	—	$0	6,068	SEC↗
Sandor Victor	Director	A Award deriv	2026-06-24	2026-06-25	6,068	—	$0	6,068	SEC↗
Albers Jeffrey W.	Director	A Award deriv	2026-06-24	2026-06-25	6,068	—	$0	6,068	SEC↗
MARAGANORE JOHN	Director	A Award deriv	2026-06-24	2026-06-25	6,068	—	$0	6,068	SEC↗
Ridloff Elena	Director	A Award deriv	2026-06-24	2026-06-25	6,068	—	$0	6,068	SEC↗
Hrustanovic Gorjan	Director	A Award deriv	2026-06-24	2026-06-25	6,068	—	$0	6,068	SEC↗
Booth Bruce	Director	A Award deriv	2026-06-24	2026-06-25	6,068	—	$0	6,068	SEC↗
Biotechnology Value Trading Fu	Director	A Award deriv	2026-06-24	2026-06-25	6,068	—	$0	6,068	SEC↗
Booth Bruce	Director	S Sale	2026-06-24	2026-06-25	2,029	$101.14	$205.2K	597,047	SEC↗
Booth Bruce	Director	S Sale	2026-06-24	2026-06-25	14,490	$101.14	$1.47M	3,343,343	SEC↗
Booth Bruce	Director	S Sale	2026-06-24	2026-06-25	14,513	$100.42	$1.46M	599,076	SEC↗
Booth Bruce	Director	S Sale	2026-06-24	2026-06-25	103,688	$100.42	$10.41M	3,357,833	SEC↗
Booth Bruce	Director	S Sale	2026-06-23	2026-06-25	173	$99.98	$17.3K	613,589	SEC↗
Booth Bruce	Director	S Sale	2026-06-23	2026-06-25	1,235	$99.98	$123.5K	3,461,521	SEC↗
Goodman Noah	Chief Business Officer	M Exercise deriv	2026-06-22	2026-06-22	2,500	—	$0	95,000	SEC↗
Goodman Noah	Chief Business Officer	S Sale	2026-06-22	2026-06-22	2,500	$99.00	$247.5K	50,195	SEC↗
Goodman Noah	Chief Business Officer	M Exercise	2026-06-22	2026-06-22	2,500	$21.05	$52.6K	52,695	SEC↗
Booth Bruce	Director	S Sale	2026-06-22	2026-06-22	1,253	$102.48	$128.4K	617,663	SEC↗
Booth Bruce	Director	S Sale	2026-06-22	2026-06-22	918	$101.61	$93.3K	618,916	SEC↗
Booth Bruce	Director	S Sale	2026-06-22	2026-06-22	7,879	$100.17	$789.2K	619,834	SEC↗
Booth Bruce	Director	S Sale	2026-06-22	2026-06-22	7,319	$99.57	$728.8K	627,713	SEC↗
Booth Bruce	Director	S Sale	2026-06-22	2026-06-22	3,603	$98.58	$355.2K	635,032	SEC↗
Booth Bruce	Director	S Sale	2026-06-22	2026-06-22	2,247	$97.68	$219.5K	638,635	SEC↗
Booth Bruce	Director	S Sale	2026-06-22	2026-06-22	2,919	$96.24	$280.9K	640,882	SEC↗
Booth Bruce	Director	S Sale	2026-06-22	2026-06-22	1,648	$95.12	$156.8K	643,801	SEC↗
Booth Bruce	Director	S Sale	2026-06-22	2026-06-22	286	$94.48	$27.0K	645,449	SEC↗
Booth Bruce	Director	S Sale	2026-06-22	2026-06-22	2,179	$92.14	$200.8K	645,735	SEC↗
Booth Bruce	Director	S Sale	2026-06-22	2026-06-22	8,990	$102.48	$921.3K	3,490,653	SEC↗
Booth Bruce	Director	S Sale	2026-06-22	2026-06-22	6,597	$101.61	$670.3K	3,499,643	SEC↗
Booth Bruce	Director	S Sale	2026-06-22	2026-06-22	56,348	$100.17	$5.64M	3,506,240	SEC↗
Booth Bruce	Director	S Sale	2026-06-22	2026-06-22	52,442	$99.57	$5.22M	3,562,588	SEC↗
Booth Bruce	Director	S Sale	2026-06-22	2026-06-22	25,976	$98.58	$2.56M	3,615,030	SEC↗
Booth Bruce	Director	S Sale	2026-06-22	2026-06-22	16,084	$97.68	$1.57M	3,641,006	SEC↗
Booth Bruce	Director	S Sale	2026-06-22	2026-06-22	20,903	$96.24	$2.01M	3,657,090	SEC↗
Booth Bruce	Director	S Sale	2026-06-22	2026-06-22	11,783	$95.12	$1.12M	3,677,993	SEC↗
Booth Bruce	Director	S Sale	2026-06-22	2026-06-22	2,035	$94.48	$192.3K	3,689,776	SEC↗
Booth Bruce	Director	S Sale	2026-06-22	2026-06-22	14,921	$92.14	$1.37M	3,691,811	SEC↗
Booth Bruce	Director	S Sale	2026-06-22	2026-06-22	9,584	$104.38	$1.00M	3,462,756	SEC↗
Booth Bruce	Director	S Sale	2026-06-22	2026-06-22	18,313	$103.42	$1.89M	3,472,340	SEC↗
Booth Bruce	Director	S Sale	2026-06-22	2026-06-22	2,560	$103.42	$264.8K	615,103	SEC↗
Booth Bruce	Director	S Sale	2026-06-22	2026-06-22	1,341	$104.38	$140.0K	613,762	SEC↗
Booth Bruce	Director	S Sale	2026-06-18	2026-06-22	62,897	$90.48	$5.69M	3,744,763	SEC↗
Booth Bruce	Director	S Sale	2026-06-18	2026-06-22	8,809	$90.48	$797.0K	653,233	SEC↗
Booth Bruce	Director	S Sale	2026-06-18	2026-06-22	793	$92.16	$73.1K	647,914	SEC↗
Booth Bruce	Director	S Sale	2026-06-18	2026-06-22	4,526	$91.85	$415.7K	648,707	SEC↗
Booth Bruce	Director	S Sale	2026-06-18	2026-06-22	32,359	$91.85	$2.97M	3,712,404	SEC↗
Booth Bruce	Director	S Sale	2026-06-18	2026-06-22	5,672	$92.16	$522.7K	3,706,732	SEC↗
Booth Bruce	Director	M Exercise deriv	2026-06-17	2026-06-22	11,741	—	$0	28,127	SEC↗
Booth Bruce	Director	M Exercise	2026-06-17	2026-06-22	11,741	$20.00	$234.8K	11,741	SEC↗
Booth Bruce	Director	S Sale	2026-06-17	2026-06-22	11,741	$89.98	$1.06M	0	SEC↗
Booth Bruce	Director	S Sale	2026-06-17	2026-06-22	92,169	$90.38	$8.33M	3,807,660	SEC↗
Booth Bruce	Director	S Sale	2026-06-17	2026-06-22	12,902	$90.38	$1.17M	662,042	SEC↗
Jacobs Bruce N.	Chief Financial Officer	M Exercise deriv	2026-06-02	2026-06-03	12,653	—	$0	0	SEC↗
Jacobs Bruce N.	Chief Financial Officer	M Exercise	2026-06-02	2026-06-03	12,653	$2.08	$26.3K	260,241	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-05-27	2026-05-27	3,679	$81.50	$299.8K	44,618	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-05-27	2026-05-27	600	$82.08	$49.2K	44,018	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-05-26	2026-05-27	4,500	$80.02	$360.1K	48,848	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-05-26	2026-05-27	551	$80.71	$44.5K	48,297	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-05-26	2026-05-27	3,800	$79.39	$301.7K	53,348	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-05-26	2026-05-27	324	$79.17	$25.7K	57,148	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-05-26	2026-05-27	3,730	$78.36	$292.3K	57,472	SEC↗
Esposito Pamela	Director	M Exercise deriv	2026-05-19	2026-05-19	1,000	—	$0	9,000	SEC↗
Esposito Pamela	Director	M Exercise	2026-05-19	2026-05-19	1,000	$31.20	$31.2K	1,000	SEC↗
Jacobs Bruce N.	Chief Financial Officer	M Exercise deriv	2026-05-18	2026-05-19	15,000	—	$0	12,653	SEC↗
Jacobs Bruce N.	Chief Financial Officer	M Exercise	2026-05-18	2026-05-19	15,000	$2.08	$31.2K	247,588	SEC↗
Ridloff Elena	Director	M Exercise deriv	2026-05-11	2026-05-11	3,000	—	$0	13,000	SEC↗
Ridloff Elena	Director	S Sale	2026-05-11	2026-05-11	3,000	$87.00	$261.0K	0	SEC↗
Ridloff Elena	Director	M Exercise	2026-05-11	2026-05-11	3,000	$31.20	$93.6K	3,000	SEC↗
Mainolfi Nello	Chief Executive Officer	M Exercise deriv	2026-04-29	2026-04-29	30,000	—	$0	215,559	SEC↗
Mainolfi Nello	Chief Executive Officer	S Sale	2026-04-29	2026-04-29	12,059	$81.70	$985.2K	667,131	SEC↗
Mainolfi Nello	Chief Executive Officer	S Sale	2026-04-29	2026-04-29	17,005	$80.74	$1.37M	679,190	SEC↗
Mainolfi Nello	Chief Executive Officer	S Sale	2026-04-29	2026-04-29	936	$82.45	$77.2K	666,195	SEC↗
Mainolfi Nello	Chief Executive Officer	M Exercise	2026-04-29	2026-04-29	30,000	$2.08	$62.4K	696,195	SEC↗
Chadwick Jeremy G	Chief Operating Officer	M Exercise deriv	2026-04-22	2026-04-24	100	—	$0	45,434	SEC↗
Chadwick Jeremy G	Chief Operating Officer	M Exercise deriv	2026-04-22	2026-04-24	200	—	$0	58,263	SEC↗
Booth Bruce	Director	M Exercise deriv	2026-04-22	2026-04-24	5,641	—	$0	0	SEC↗
Booth Bruce	Director	M Exercise deriv	2026-04-22	2026-04-24	259	—	$0	39,868	SEC↗
Chadwick Jeremy G	Chief Operating Officer	M Exercise	2026-04-22	2026-04-24	200	$43.50	$8.7K	61,502	SEC↗
Chadwick Jeremy G	Chief Operating Officer	M Exercise	2026-04-22	2026-04-24	100	$30.17	$3.0K	61,302	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-04-22	2026-04-24	300	$90.00	$27.0K	61,202	SEC↗
Booth Bruce	Director	M Exercise	2026-04-22	2026-04-24	259	$20.00	$5.2K	5,900	SEC↗
Booth Bruce	Director	S Sale	2026-04-22	2026-04-24	12	$90.08	$1.1K	674,944	SEC↗
Booth Bruce	Director	S Sale	2026-04-22	2026-04-24	5,900	$89.96	$530.8K	0	SEC↗
Booth Bruce	Director	S Sale	2026-04-22	2026-04-24	88	$90.08	$7.9K	3,899,829	SEC↗
Booth Bruce	Director	M Exercise	2026-04-22	2026-04-24	5,641	$14.18	$80.0K	5,641	SEC↗
Booth Bruce	Director	M Exercise deriv	2026-04-15	2026-04-16	2,200	—	$0	5,641	SEC↗
Chadwick Jeremy G	Chief Operating Officer	M Exercise deriv	2026-04-15	2026-04-16	1,300	—	$0	58,463	SEC↗
Booth Bruce	Director	S Sale	2026-04-15	2026-04-16	385	$90.10	$34.7K	674,956	SEC↗
Booth Bruce	Director	S Sale	2026-04-15	2026-04-16	2,750	$90.10	$247.8K	3,899,917	SEC↗
Booth Bruce	Director	S Sale	2026-04-15	2026-04-16	2,200	$89.95	$197.9K	0	SEC↗
Booth Bruce	Director	M Exercise	2026-04-15	2026-04-16	2,200	$14.18	$31.2K	2,200	SEC↗
Chadwick Jeremy G	Chief Operating Officer	M Exercise	2026-04-15	2026-04-16	1,300	$43.50	$56.5K	62,502	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-04-15	2026-04-16	1,300	$90.00	$117.0K	61,202	SEC↗
Booth Bruce	Director	M Exercise deriv	2026-04-14	2026-04-16	4,159	—	$0	7,841	SEC↗
Chadwick Jeremy G	Chief Operating Officer	M Exercise deriv	2026-04-14	2026-04-16	4,466	—	$0	45,534	SEC↗
Chadwick Jeremy G	Chief Operating Officer	M Exercise deriv	2026-04-14	2026-04-16	785	—	$0	59,763	SEC↗
Booth Bruce	Director	S Sale	2026-04-14	2026-04-16	4,159	$89.97	$374.2K	0	SEC↗
Booth Bruce	Director	M Exercise	2026-04-14	2026-04-16	4,159	$14.18	$59.0K	4,159	SEC↗
Chadwick Jeremy G	Chief Operating Officer	M Exercise	2026-04-14	2026-04-16	785	$43.50	$34.1K	66,453	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-04-14	2026-04-16	5,251	$90.00	$472.6K	61,202	SEC↗
Chadwick Jeremy G	Chief Operating Officer	M Exercise	2026-04-14	2026-04-16	4,466	$30.17	$134.7K	65,668	SEC↗
Goodman Noah	Chief Business Officer	S Sale	2026-04-14	2026-04-16	1,347	$90.00	$121.2K	50,195	SEC↗
Goodman Noah	Chief Business Officer	S Sale	2026-04-10	2026-04-10	2,000	$87.35	$174.7K	51,542	SEC↗
Goodman Noah	Chief Business Officer	M Exercise deriv	2026-04-09	2026-04-10	2,500	—	$0	97,500	SEC↗
Goodman Noah	Chief Business Officer	S Sale	2026-04-09	2026-04-10	2,500	$89.00	$222.5K	53,542	SEC↗
Goodman Noah	Chief Business Officer	S Sale	2026-04-09	2026-04-10	2,670	$87.11	$232.6K	56,042	SEC↗
Goodman Noah	Chief Business Officer	M Exercise	2026-04-09	2026-04-10	2,500	$21.05	$52.6K	61,806	SEC↗
Goodman Noah	Chief Business Officer	S Sale	2026-04-09	2026-04-10	3,094	$86.62	$268.0K	58,712	SEC↗
Chadwick Jeremy G	Chief Operating Officer	M Exercise deriv	2026-04-01	2026-04-01	14,640	—	$0	68,633	SEC↗
Ridloff Elena	Director	M Exercise deriv	2026-04-01	2026-04-01	4,600	—	$0	0	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-04-01	2026-04-01	1,100	$86.05	$94.7K	61,202	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-04-01	2026-04-01	13,540	$85.41	$1.16M	62,302	SEC↗
Chadwick Jeremy G	Chief Operating Officer	M Exercise	2026-04-01	2026-04-01	14,640	$29.64	$433.9K	75,842	SEC↗
Ridloff Elena	Director	M Exercise	2026-04-01	2026-04-01	4,600	$14.18	$65.2K	4,600	SEC↗
Ridloff Elena	Director	S Sale	2026-04-01	2026-04-01	1,200	$86.05	$103.3K	0	SEC↗
Ridloff Elena	Director	S Sale	2026-04-01	2026-04-01	3,400	$85.19	$289.6K	1,200	SEC↗
Chadwick Jeremy G	Chief Operating Officer	M Exercise deriv	2026-03-31	2026-04-01	7,600	—	$0	83,273	SEC↗
Ridloff Elena	Director	M Exercise deriv	2026-03-31	2026-04-01	7,400	—	$0	4,600	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-03-31	2026-04-01	7,600	$85.38	$648.9K	61,202	SEC↗
Chadwick Jeremy G	Chief Operating Officer	M Exercise	2026-03-31	2026-04-01	7,600	$29.64	$225.3K	68,802	SEC↗
Ridloff Elena	Director	M Exercise	2026-03-31	2026-04-01	7,400	$14.18	$104.9K	7,400	SEC↗
Ridloff Elena	Director	S Sale	2026-03-31	2026-04-01	7,400	$85.37	$631.7K	0	SEC↗
Chadwick Jeremy G	Chief Operating Officer	M Exercise deriv	2026-03-25	2026-03-25	24,727	—	$0	90,873	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-03-25	2026-03-25	24,727	$80.26	$1.98M	61,202	SEC↗
Chadwick Jeremy G	Chief Operating Officer	M Exercise	2026-03-25	2026-03-25	24,727	$29.64	$732.9K	85,929	SEC↗
Chadwick Jeremy G	Chief Operating Officer	M Exercise deriv	2026-03-23	2026-03-25	84,400	—	$0	115,600	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-03-23	2026-03-25	1,200	$80.05	$96.1K	61,202	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-03-23	2026-03-25	22,756	$76.73	$1.75M	129,696	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-03-23	2026-03-25	52,975	$77.21	$4.09M	76,721	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-03-23	2026-03-25	8,214	$78.40	$644.0K	68,507	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-03-23	2026-03-25	6,105	$79.87	$487.6K	62,402	SEC↗
Chadwick Jeremy G	Chief Operating Officer	M Exercise	2026-03-23	2026-03-25	84,400	$29.64	$2.50M	152,452	SEC↗
Esposito Pamela	Director	M Exercise deriv	2026-03-20	2026-03-20	2,500	—	$0	0	SEC↗
Esposito Pamela	Director	M Exercise	2026-03-20	2026-03-20	2,500	$49.10	$122.8K	2,500	SEC↗
Esposito Pamela	Director	S Sale	2026-03-20	2026-03-20	700	$77.71	$54.4K	1,800	SEC↗
Esposito Pamela	Director	S Sale	2026-03-20	2026-03-20	600	$79.24	$47.5K	1,200	SEC↗
Esposito Pamela	Director	S Sale	2026-03-20	2026-03-20	1,200	$79.94	$95.9K	0	SEC↗
Chadwick Jeremy G	Chief Operating Officer	M Exercise deriv	2026-03-11	2026-03-11	20,000	—	$0	60,548	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-03-11	2026-03-11	11,111	$83.72	$930.2K	68,052	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-03-11	2026-03-11	12,882	$83.10	$1.07M	79,163	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-03-11	2026-03-11	1,765	$82.13	$145.0K	92,045	SEC↗
Chadwick Jeremy G	Chief Operating Officer	M Exercise	2026-03-11	2026-03-11	20,000	$43.50	$870.0K	93,810	SEC↗
Jacobs Bruce N.	Chief Financial Officer	S Sale	2026-03-04	2026-03-04	2,519	$85.04	$214.2K	234,472	SEC↗
Jacobs Bruce N.	Chief Financial Officer	S Sale	2026-03-04	2026-03-04	447	$86.62	$38.7K	232,588	SEC↗
Jacobs Bruce N.	Chief Financial Officer	S Sale	2026-03-04	2026-03-04	492	$84.00	$41.3K	236,991	SEC↗
Jacobs Bruce N.	Chief Financial Officer	S Sale	2026-03-04	2026-03-04	1,437	$85.78	$123.3K	233,035	SEC↗
Gollob Jared	Chief Medical Officer	S Sale	2026-03-04	2026-03-04	447	$86.62	$38.7K	117,134	SEC↗
Gollob Jared	Chief Medical Officer	S Sale	2026-03-04	2026-03-04	2,519	$85.04	$214.2K	119,018	SEC↗
Gollob Jared	Chief Medical Officer	S Sale	2026-03-04	2026-03-04	492	$84.00	$41.3K	121,537	SEC↗
Gollob Jared	Chief Medical Officer	S Sale	2026-03-04	2026-03-04	1,437	$85.78	$123.3K	117,581	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-03-04	2026-03-04	394	$84.00	$33.1K	77,335	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-03-04	2026-03-04	1,150	$85.78	$98.6K	74,168	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-03-04	2026-03-04	358	$86.62	$31.0K	73,810	SEC↗
Chadwick Jeremy G	Chief Operating Officer	S Sale	2026-03-04	2026-03-04	2,017	$85.04	$171.5K	75,318	SEC↗