Open-mkt buys · 90d
—
0 trades · 0 insiders
Open-mkt sales · 90d
—
0 trades · 0 insiders
Net · 90d
$0
Insiders on file
30
Daily buy vs sell · 90 days
No data yet.
Insiders
| Insider | Role | Trades | Bought | Sold | Last trade |
|---|---|---|---|---|---|
| Smith W Bradford | Director | 6 | $0 | $0 | 2026-05-14 |
| Cavalier Jason | Principal Financial Officer | 9 | $0 | $8.7K | 2026-04-01 |
| Palasis Maria | Principal Executive Officer | 15 | $0 | $19.7K | 2026-04-01 |
| PERCEPTIVE ADVISORS LLC | Director, 10% Owner | 21 | $25.00M | $182.5K | 2025-11-13 |
| EDELMAN JOSEPH | 10% Owner | 6 | $0 | $344.3K | 2025-11-10 |
| snyderman nancy lynn MD | Director | 7 | $10.0K | $0 | 2025-05-14 |
| MERRIFIELD C ANN | Director | 9 | $70.1K | $0 | 2025-05-14 |
| TOBIN JAMES R | Director | 4 | $0 | $0 | 2025-05-14 |
| Waksal Harlan | Executive Chair | 7 | $1.07M | $0 | 2024-12-09 |
| ALTMAN MICHAEL SETH | Director | 5 | $0 | $0 | 2024-06-13 |
| Poukalov Konstantin | Director | 5 | $0 | $0 | 2024-06-13 |
| Nieman Richard | Chief Medical Officer | 3 | $0 | $0 | 2024-01-30 |
| Bishop John E | Chief Technology Officer | 2 | $0 | $0 | 2024-01-30 |
| ANDERSON EDWARD T | Director, 10% Owner | 53 | $19.00M | $386.9K | 2023-06-30 |
| Perceptive LS (A), LLC | 10% Owner | 2 | $8.99M | $0 | 2023-05-31 |
| North Bridge Venture Partners VI L P | 10% Owner | 6 | $4.50M | $0 | 2023-05-31 |
| Richard Robert E. | SVP, Technical Operations | 5 | $0 | $0 | 2023-01-31 |
| Noyes Corinne | See Remarks | 5 | $0 | $0 | 2023-01-31 |
| NORTH BRIDGE VENTURE PARTNERS V A LP | 10% Owner | 3 | $10.00M | $0 | 2022-04-12 |
| Nelson Pamela E. | Senior VP, Regulatory Affairs | 3 | $0 | $0 | 2022-02-12 |
| Elsey R Don | CFO, Treasurer & Secretary | 2 | $0 | $0 | 2021-02-08 |
| Soleus Capital Master Fund, L.P. | 10% Owner | 8 | $2.48M | $270.5K | 2020-05-05 |
| Roberts Carmichael | 10% Owner | 2 | $0 | $0 | 2020-05-05 |
| PERCEPTIVE LIFE SCIENCES MASTER FUND LTD | 10% Owner | 1 | $10.00M | $0 | 2020-05-05 |
| LANGER ROBERT | Director | 3 | $0 | $0 | 2020-05-05 |
| WHITESIDES GEORGE M | Director | 6 | $0 | $0 | 2020-05-05 |
| DAMORE RICHARD A | 10% Owner | 39 | $4.00M | $386.9K | 2020-05-05 |
| POLARIS VENTURE PARTNERS IV LP | 10% Owner | 10 | $0 | $0 | 2020-05-05 |
| MCGUIRE TERRANCE | 10% Owner | 44 | $1.00M | $154.8K | 2020-05-05 |
| Edgerly-Pflug Laura | See Remarks | 1 | $0 | $0 | 2020-04-30 |
Trade history
| Insider | Role | Code | Trade | Filed | Shares | Price | Value | Owned after | |
|---|---|---|---|---|---|---|---|---|---|
| Smith W Bradford | Director | D To issuer | 2026-05-14 | 2026-05-15 | 640 | — | $0 | 0 | SEC↗ |
| Cavalier Jason | Principal Financial Officer | D To issuer | 2026-04-01 | 2026-04-03 | 667 | — | $0 | 517,880 | SEC↗ |
| Palasis Maria | Principal Executive Officer | D To issuer | 2026-04-01 | 2026-04-03 | 2,000 | — | $0 | 1,094,733 | SEC↗ |
| Palasis Maria | President & CEO | S Sale | 2026-01-06 | 2026-01-08 | 1,702 | $3.36 | $5.7K | 1,096,733 | SEC↗ |
| Cavalier Jason | Chief Financial Officer | S Sale | 2026-01-06 | 2026-01-08 | 769 | $3.36 | $2.6K | 518,547 | SEC↗ |
| PERCEPTIVE ADVISORS LLC | 10% Owner | S Sale | 2025-11-13 | 2025-11-13 | 3,213 | $3.90 | $12.5K | 14,026 | SEC↗ |
| PERCEPTIVE ADVISORS LLC | 10% Owner | S Sale | 2025-11-13 | 2025-11-13 | 28,597 | $3.90 | $111.5K | 124,859 | SEC↗ |
| PERCEPTIVE ADVISORS LLC | 10% Owner | S Sale | 2025-11-12 | 2025-11-13 | 7,862 | $4.06 | $31.9K | 153,456 | SEC↗ |
| PERCEPTIVE ADVISORS LLC | 10% Owner | S Sale | 2025-11-12 | 2025-11-13 | 883 | $4.06 | $3.6K | 17,239 | SEC↗ |
| PERCEPTIVE ADVISORS LLC | 10% Owner | S Sale | 2025-11-11 | 2025-11-13 | 4,783 | $4.31 | $20.6K | 161,318 | SEC↗ |
| PERCEPTIVE ADVISORS LLC | 10% Owner | S Sale | 2025-11-11 | 2025-11-13 | 537 | $4.31 | $2.3K | 18,122 | SEC↗ |
| EDELMAN JOSEPH | 10% Owner | S Sale | 2025-11-10 | 2025-11-10 | 16,633 | $4.54 | $75.5K | 166,101 | SEC↗ |
| EDELMAN JOSEPH | 10% Owner | S Sale | 2025-11-10 | 2025-11-10 | 1,869 | $4.54 | $8.5K | 18,659 | SEC↗ |
| EDELMAN JOSEPH | 10% Owner | S Sale | 2025-11-07 | 2025-11-10 | 17,746 | $4.75 | $84.3K | 182,734 | SEC↗ |
| EDELMAN JOSEPH | 10% Owner | S Sale | 2025-11-07 | 2025-11-10 | 1,993 | $4.75 | $9.5K | 20,528 | SEC↗ |
| EDELMAN JOSEPH | 10% Owner | S Sale | 2025-11-06 | 2025-11-10 | 3,247 | $5.18 | $16.8K | 22,521 | SEC↗ |
| EDELMAN JOSEPH | 10% Owner | S Sale | 2025-11-06 | 2025-11-10 | 28,902 | $5.18 | $149.7K | 200,480 | SEC↗ |
| Palasis Maria | President & CEO | A Award deriv | 2025-10-01 | 2025-10-03 | 3,667 | — | $0 | 7,333 | SEC↗ |
| Cavalier Jason | Chief Financial Officer | S Sale | 2025-07-10 | 2025-07-14 | 684 | $8.91 | $6.1K | 519,316 | SEC↗ |
| Palasis Maria | President & CEO | S Sale | 2025-07-10 | 2025-07-14 | 1,565 | $8.91 | $13.9K | 1,098,435 | SEC↗ |
| Smith W Bradford | Director | A Award deriv | 2025-05-14 | 2025-05-16 | 32,000 | — | $0 | 32,000 | SEC↗ |
| snyderman nancy lynn MD | Director | A Award deriv | 2025-05-14 | 2025-05-16 | 32,000 | — | $0 | 32,000 | SEC↗ |
| TOBIN JAMES R | Director | A Award deriv | 2025-05-14 | 2025-05-16 | 32,000 | — | $0 | 32,000 | SEC↗ |
| MERRIFIELD C ANN | Director | A Award deriv | 2025-05-14 | 2025-05-16 | 32,000 | — | $0 | 32,000 | SEC↗ |
| Cavalier Jason | Chief Financial Officer | A Award | 2025-01-08 | 2025-01-10 | 420,000 | — | $0 | 520,000 | SEC↗ |
| Palasis Maria | President & CEO | A Award | 2025-01-08 | 2025-01-10 | 800,000 | — | $0 | 1,100,000 | SEC↗ |
| Waksal Harlan | Executive Chair | A Award deriv | 2024-12-09 | 2024-12-11 | 128,333 | — | $0 | 0 | SEC↗ |
| Palasis Maria | President & CEO | A Award deriv | 2024-12-09 | 2024-12-11 | 183,333 | — | $0 | 183,333 | SEC↗ |
| Cavalier Jason | Chief Financial Officer | A Award | 2024-10-16 | 2024-10-18 | 100,000 | — | $0 | 100,000 | SEC↗ |
| Palasis Maria | President & CEO | A Award | 2024-10-16 | 2024-10-18 | 300,000 | — | $0 | 300,000 | SEC↗ |
| MERRIFIELD C ANN | Director | A Award deriv | 2024-06-13 | 2024-06-14 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Smith W Bradford | Director | A Award deriv | 2024-06-13 | 2024-06-14 | 30,000 | — | $0 | 30,000 | SEC↗ |
| snyderman nancy lynn MD | Director | A Award deriv | 2024-06-13 | 2024-06-14 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Poukalov Konstantin | Director | A Award deriv | 2024-06-13 | 2024-06-14 | 30,000 | — | $0 | 30,000 | SEC↗ |
| TOBIN JAMES R | Director | A Award deriv | 2024-06-13 | 2024-06-14 | 30,000 | — | $0 | 30,000 | SEC↗ |
| ALTMAN MICHAEL SETH | Director | A Award deriv | 2024-06-13 | 2024-06-14 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Palasis Maria | President & CEO | A Award deriv | 2024-03-18 | 2024-03-20 | 500,000 | — | $0 | 500,000 | SEC↗ |
| Waksal Harlan | Executive Chair | A Award | 2024-03-18 | 2024-03-20 | 275,000 | — | $0 | 536,966 | SEC↗ |
| Cavalier Jason | Chief Financial Officer | A Award deriv | 2024-01-30 | 2024-02-01 | 200,000 | — | $0 | 200,000 | SEC↗ |
| Nieman Richard | Chief Medical Officer | A Award deriv | 2024-01-30 | 2024-02-01 | 200,000 | — | $0 | 200,000 | SEC↗ |
| Bishop John E | Chief Technology Officer | A Award deriv | 2024-01-30 | 2024-02-01 | 200,000 | — | $0 | 200,000 | SEC↗ |
| Waksal Harlan | Executive Chair | P Buy | 2023-11-10 | 2023-11-13 | 25,000 | $2.96 | $74.0K | 261,966 | SEC↗ |
| snyderman nancy lynn MD | Director | A Award deriv | 2023-06-30 | 2023-07-05 | 20,000 | — | $0 | 20,000 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | A Award deriv | 2023-06-30 | 2023-07-05 | 20,000 | — | $0 | 20,000 | SEC↗ |
| MERRIFIELD C ANN | Director | A Award deriv | 2023-06-30 | 2023-07-05 | 20,000 | — | $0 | 20,000 | SEC↗ |
| ALTMAN MICHAEL SETH | Director | A Award deriv | 2023-06-30 | 2023-07-05 | 20,000 | — | $0 | 20,000 | SEC↗ |
| Poukalov Konstantin | Director | A Award deriv | 2023-06-30 | 2023-07-05 | 20,000 | — | $0 | 20,000 | SEC↗ |
| Smith W Bradford | Director | A Award deriv | 2023-06-30 | 2023-07-05 | 20,000 | — | $0 | 20,000 | SEC↗ |
| TOBIN JAMES R | Director | A Award deriv | 2023-06-30 | 2023-07-05 | 20,000 | — | $0 | 20,000 | SEC↗ |
| Palasis Maria | President & CEO | A Award deriv | 2023-06-15 | 2023-07-12 | 150,000 | — | $0 | 150,000 | SEC↗ |
| Palasis Maria | President & CEO | A Award deriv | 2023-06-15 | 2023-06-26 | 150,000 | — | $0 | 150,000 | SEC↗ |
| Perceptive LS (A), LLC | 10% Owner | P Buy deriv | 2023-05-31 | 2023-06-02 | 1,805,416 | — | $0 | 1,805,416 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | P Buy deriv | 2023-05-31 | 2023-06-02 | 601,806 | $0.13 | $78.2K | 601,806 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | P Buy deriv | 2023-05-31 | 2023-06-02 | 201,929 | $0.13 | $26.3K | 201,929 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | P Buy deriv | 2023-05-31 | 2023-06-02 | 98,973 | $0.13 | $12.9K | 98,973 | SEC↗ |
| North Bridge Venture Partners | 10% Owner | P Buy deriv | 2023-05-31 | 2023-06-02 | 601,806 | $0.13 | $78.2K | 601,806 | SEC↗ |
| North Bridge Venture Partners | 10% Owner | P Buy deriv | 2023-05-31 | 2023-06-02 | 201,929 | $0.13 | $26.3K | 201,929 | SEC↗ |
| North Bridge Venture Partners | 10% Owner | P Buy deriv | 2023-05-31 | 2023-06-02 | 98,973 | $0.13 | $12.9K | 98,973 | SEC↗ |
| Perceptive LS (A), LLC | 10% Owner | P Buy | 2023-05-31 | 2023-06-02 | 3,610,832 | $2.49 | $8.99M | 11,469,117 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | P Buy | 2023-05-31 | 2023-06-02 | 197,946 | $2.43 | $481.0K | 1,107,370 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | P Buy | 2023-05-31 | 2023-06-02 | 1,203,612 | $2.43 | $2.92M | 2,521,745 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | P Buy | 2023-05-31 | 2023-06-02 | 403,858 | $2.43 | $981.4K | 2,259,301 | SEC↗ |
| North Bridge Venture Partners | 10% Owner | P Buy | 2023-05-31 | 2023-06-02 | 197,946 | $2.43 | $481.0K | 1,107,370 | SEC↗ |
| North Bridge Venture Partners | 10% Owner | P Buy | 2023-05-31 | 2023-06-02 | 1,203,612 | $2.43 | $2.92M | 2,521,745 | SEC↗ |
| North Bridge Venture Partners | 10% Owner | P Buy | 2023-05-31 | 2023-06-02 | 403,858 | $2.43 | $981.4K | 2,259,301 | SEC↗ |
| Bishop John E | Chief Technology Officer | A Award deriv | 2023-02-27 | 2023-02-28 | 220,000 | — | $0 | 220,000 | SEC↗ |
| Nieman Richard | Chief Medical Officer | A Award deriv | 2023-01-31 | 2023-02-02 | 55,537 | — | $0 | 55,537 | SEC↗ |
| Palasis Maria | President & CEO | A Award deriv | 2023-01-31 | 2023-02-02 | 250,000 | — | $0 | 250,000 | SEC↗ |
| Cavalier Jason | Chief Financial Officer | A Award deriv | 2023-01-31 | 2023-02-02 | 140,000 | — | $0 | 140,000 | SEC↗ |
| Noyes Corinne | See Remarks | A Award deriv | 2023-01-31 | 2023-02-02 | 55,000 | — | $0 | 55,000 | SEC↗ |
| Waksal Harlan | Executive Chair | A Award deriv | 2023-01-31 | 2023-02-02 | 200,000 | — | $0 | 200,000 | SEC↗ |
| Richard Robert E. | SVP, Technical Operations | A Award deriv | 2023-01-31 | 2023-02-02 | 45,000 | — | $0 | 45,000 | SEC↗ |
| Noyes Corinne | See Remarks | A Award | 2023-01-31 | 2023-02-02 | 36,667 | — | $0 | 36,667 | SEC↗ |
| Richard Robert E. | SVP, Technical Operations | A Award | 2023-01-31 | 2023-02-02 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Nieman Richard | Chief Medical Officer | A Award deriv | 2022-07-11 | 2022-07-12 | 230,000 | — | $0 | 230,000 | SEC↗ |
| snyderman nancy lynn MD | Director | A Award deriv | 2022-06-16 | 2022-06-21 | 7,250 | — | $0 | 7,250 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | A Award deriv | 2022-06-16 | 2022-06-21 | 7,250 | — | $0 | 7,250 | SEC↗ |
| Waksal Harlan | Executive Chair | A Award deriv | 2022-06-16 | 2022-06-21 | 953,002 | — | $0 | 953,002 | SEC↗ |
| Poukalov Konstantin | Director | A Award deriv | 2022-06-16 | 2022-06-21 | 7,250 | — | $0 | 7,250 | SEC↗ |
| Smith W Bradford | Director | A Award deriv | 2022-06-16 | 2022-06-21 | 7,250 | — | $0 | 7,250 | SEC↗ |
| MERRIFIELD C ANN | Director | A Award deriv | 2022-06-16 | 2022-06-21 | 7,250 | — | $0 | 7,250 | SEC↗ |
| ALTMAN MICHAEL SETH | Director | A Award deriv | 2022-06-16 | 2022-06-21 | 7,250 | — | $0 | 7,250 | SEC↗ |
| MERRIFIELD C ANN | Director | P Buy | 2022-06-10 | 2022-06-13 | 4,000 | $5.05 | $20.2K | 11,328 | SEC↗ |
| MERRIFIELD C ANN | Director | P Buy | 2022-05-16 | 2022-05-17 | 328 | $5.00 | $1.6K | 7,328 | SEC↗ |
| MERRIFIELD C ANN | Director | P Buy | 2022-05-13 | 2022-05-17 | 3,500 | $4.81 | $16.8K | 7,000 | SEC↗ |
| Waksal Harlan | Executive Chair | P Buy | 2022-04-12 | 2022-04-13 | 236,966 | $4.22 | $1000.0K | 236,966 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | P Buy | 2022-04-12 | 2022-04-14 | 527,806 | $4.22 | $2.23M | 909,424 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | P Buy | 2022-04-12 | 2022-04-14 | 765,010 | $4.22 | $3.23M | 1,318,133 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | P Buy | 2022-04-12 | 2022-04-14 | 118,483 | $4.22 | $500.0K | 118,483 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | P Buy | 2022-04-12 | 2022-04-14 | 1,076,851 | $4.22 | $4.54M | 1,855,443 | SEC↗ |
| NORTH BRIDGE VENTURE PARTNERS | 10% Owner | P Buy | 2022-04-12 | 2022-04-14 | 527,806 | $4.22 | $2.23M | 909,424 | SEC↗ |
| NORTH BRIDGE VENTURE PARTNERS | 10% Owner | P Buy | 2022-04-12 | 2022-04-14 | 765,010 | $4.22 | $3.23M | 1,318,133 | SEC↗ |
| NORTH BRIDGE VENTURE PARTNERS | 10% Owner | P Buy | 2022-04-12 | 2022-04-14 | 1,076,851 | $4.22 | $4.54M | 1,855,443 | SEC↗ |
| PERCEPTIVE ADVISORS LLC | Director, 10% Owner | P Buy | 2022-04-12 | 2022-04-14 | 5,924,170 | $4.22 | $25.00M | 7,858,285 | SEC↗ |
| TOBIN JAMES R | Director | A Award deriv | 2022-03-04 | 2022-03-08 | 14,500 | — | $0 | 14,500 | SEC↗ |
| Waksal Harlan | Executive Chair | A Award deriv | 2022-02-16 | 2022-02-18 | 520,000 | — | $0 | 520,000 | SEC↗ |
| Palasis Maria | President & CEO | A Award deriv | 2022-02-16 | 2022-02-18 | 175,000 | — | $0 | 175,000 | SEC↗ |
| Richard Robert E. | SVP, Technical Operations | A Award deriv | 2022-02-12 | 2022-02-15 | 35,000 | — | $0 | 35,000 | SEC↗ |
| Cavalier Jason | Chief Financial Officer | A Award deriv | 2022-02-12 | 2022-02-15 | 15,605 | — | $0 | 15,605 | SEC↗ |
| Nelson Pamela E. | SVP, Regulatory Affairs | A Award deriv | 2022-02-12 | 2022-02-15 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Palasis Maria | President & CEO | A Award deriv | 2022-02-12 | 2022-02-15 | 127,400 | — | $0 | 127,400 | SEC↗ |
| Noyes Corinne | See Remarks | A Award deriv | 2022-02-12 | 2022-02-15 | 32,000 | — | $0 | 32,000 | SEC↗ |
| Cavalier Jason | Chief Financial Officer | A Award deriv | 2021-09-13 | 2021-09-15 | 104,000 | — | $0 | 104,000 | SEC↗ |
| MERRIFIELD C ANN | Director | P Buy | 2021-06-17 | 2021-06-22 | 3,500 | $8.97 | $31.4K | 3,500 | SEC↗ |
| ANDERSON EDWARD T | Director | A Award deriv | 2021-05-26 | 2021-05-28 | 7,250 | — | $0 | 7,250 | SEC↗ |
| Smith W Bradford | Director | A Award deriv | 2021-05-26 | 2021-05-28 | 7,250 | — | $0 | 7,250 | SEC↗ |
| MERRIFIELD C ANN | Director | A Award deriv | 2021-05-26 | 2021-05-28 | 7,250 | — | $0 | 7,250 | SEC↗ |
| snyderman nancy lynn MD | Director | A Award deriv | 2021-05-26 | 2021-05-28 | 7,250 | — | $0 | 7,250 | SEC↗ |
| Poukalov Konstantin | Director | A Award deriv | 2021-05-26 | 2021-05-28 | 7,250 | — | $0 | 7,250 | SEC↗ |
| ALTMAN MICHAEL SETH | Director | A Award deriv | 2021-05-26 | 2021-05-28 | 7,250 | — | $0 | 7,250 | SEC↗ |
| Richard Robert E. | SVP of R&D | A Award deriv | 2021-02-08 | 2021-02-10 | 18,000 | — | $0 | 18,000 | SEC↗ |
| Noyes Corinne | See Remarks | A Award deriv | 2021-02-08 | 2021-02-10 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Nelson Pamela E. | Senior VP, Regulatory Affair | A Award deriv | 2021-02-08 | 2021-02-10 | 13,000 | — | $0 | 13,000 | SEC↗ |
| Palasis Maria | President & CEO | A Award deriv | 2021-02-08 | 2021-02-10 | 120,000 | — | $0 | 120,000 | SEC↗ |
| Elsey R Don | CFO, Treasurer & Secretary | A Award deriv | 2021-02-08 | 2021-02-10 | 45,000 | — | $0 | 45,000 | SEC↗ |
| snyderman nancy lynn MD | Director | P Buy | 2020-12-16 | 2020-12-17 | 1,025 | $9.72 | $10.0K | 1,025 | SEC↗ |
| snyderman nancy lynn MD | Director | A Award deriv | 2020-10-27 | 2020-10-29 | 14,500 | — | $0 | 14,500 | SEC↗ |
| Nelson Pamela E. | Senior VP, Regulatory Affair | A Award deriv | 2020-08-03 | 2020-08-05 | 35,000 | — | $0 | 35,000 | SEC↗ |
| Richard Robert E. | SVP of R&D | A Award deriv | 2020-06-24 | 2020-06-26 | 35,000 | — | $0 | 35,000 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 58,980 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 86,101 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 167,809 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 8,610,081 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 22,580 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 32,961 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 64,237 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 3,296,014 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 42,941 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 62,687 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 122,177 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 6,268,687 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | X Exercise deriv | 2020-05-05 | 2020-05-06 | 118 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | X Exercise deriv | 2020-05-05 | 2020-05-06 | 173 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | X Exercise deriv | 2020-05-05 | 2020-05-06 | 337 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | X Exercise deriv | 2020-05-05 | 2020-05-06 | 17,304 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 13,625 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 19,890 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 38,765 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 1,988,991 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 43,966 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 64,183 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 125,094 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 6,418,387 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 52,700 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 76,934 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 149,944 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 7,693,406 | — | $0 | 0 | SEC↗ |
| LANGER ROBERT | Director | C Conversion deriv | 2020-05-05 | 2020-05-06 | 23,057 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 567,420 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | X Exercise deriv | 2020-05-05 | 2020-05-06 | 10,322 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | X Exercise deriv | 2020-05-05 | 2020-05-06 | 21,060 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 1,545,953 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 1,186,496 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 2,420,729 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 1,995,489 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 1,531,507 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 3,124,633 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 2,391,895 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 1,835,743 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 3,745,346 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 2,929,790 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 2,248,569 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 4,587,608 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 2,088,772 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 1,603,102 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 3,270,702 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 1,948,948 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 1,495,786 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 3,051,758 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 1,647,727 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 541,973 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 1,105,754 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 1,725,090 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | X Exercise deriv | 2020-05-05 | 2020-05-06 | 13,449 | — | $0 | 0 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 1,157,670 | — | $0 | 0 | SEC↗ |
| Roberts Carmichael | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 14,318 | — | $0 | 0 | SEC↗ |
| POLARIS VENTURE PARTNERS IV LP | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 3,234,812 | — | $0 | 0 | SEC↗ |
| POLARIS VENTURE PARTNERS IV LP | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 3,386,690 | — | $0 | 0 | SEC↗ |
| POLARIS VENTURE PARTNERS IV LP | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 63,490 | — | $0 | 0 | SEC↗ |
| POLARIS VENTURE PARTNERS IV LP | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 15,513 | — | $0 | 0 | SEC↗ |
| POLARIS VENTURE PARTNERS IV LP | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 827,483 | — | $0 | 0 | SEC↗ |
| POLARIS VENTURE PARTNERS IV LP | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 65,267 | — | $0 | 0 | SEC↗ |
| POLARIS VENTURE PARTNERS IV LP | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 3,481,517 | — | $0 | 0 | SEC↗ |
| POLARIS VENTURE PARTNERS IV LP | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 60,642 | — | $0 | 0 | SEC↗ |
| WHITESIDES GEORGE M | Director | C Conversion deriv | 2020-05-05 | 2020-05-06 | 55,991 | — | $0 | 0 | SEC↗ |
| WHITESIDES GEORGE M | Director | C Conversion deriv | 2020-05-05 | 2020-05-06 | 67,672 | — | $0 | 0 | SEC↗ |
| WHITESIDES GEORGE M | Director | C Conversion deriv | 2020-05-05 | 2020-05-06 | 97,216 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 1,531,507 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 3,124,633 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | X Exercise deriv | 2020-05-05 | 2020-05-06 | 13,449 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 1,995,489 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | X Exercise deriv | 2020-05-05 | 2020-05-06 | 10,322 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 2,391,895 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 1,835,743 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 3,745,346 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 2,929,790 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 2,248,569 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 4,587,608 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 2,088,772 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 1,603,102 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 3,270,702 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 1,948,948 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 1,495,786 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 3,051,758 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 1,647,727 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 541,973 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 1,105,754 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 1,725,090 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 567,420 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 1,157,670 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | X Exercise deriv | 2020-05-05 | 2020-05-06 | 21,060 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 1,545,953 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 1,186,496 | — | $0 | 0 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 2,420,729 | — | $0 | 0 | SEC↗ |
| PERCEPTIVE ADVISORS LLC | Director, 10% Owner | X Exercise deriv | 2020-05-05 | 2020-05-06 | 339,604 | — | $0 | 0 | SEC↗ |
| PERCEPTIVE ADVISORS LLC | Director, 10% Owner | X Exercise deriv | 2020-05-05 | 2020-05-06 | 141,221 | — | $0 | 0 | SEC↗ |
| PERCEPTIVE ADVISORS LLC | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 16,232,511 | — | $0 | 0 | SEC↗ |
| PERCEPTIVE ADVISORS LLC | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 39,035,325 | — | $0 | 0 | SEC↗ |
| PERCEPTIVE ADVISORS LLC | Director, 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-06 | 26,666,666 | — | $0 | 0 | SEC↗ |
| Soleus Capital Master Fund, L. | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-15 | 3,607,224 | — | $0 | 0 | SEC↗ |
| Soleus Capital Master Fund, L. | 10% Owner | X Exercise deriv | 2020-05-05 | 2020-05-15 | 31,382 | — | $0 | 0 | SEC↗ |
| Soleus Capital Master Fund, L. | 10% Owner | C Conversion deriv | 2020-05-05 | 2020-05-15 | 11,666,666 | — | $0 | 0 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion | 2020-05-05 | 2020-05-06 | 19,370 | — | $0 | 19,370 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion | 2020-05-05 | 2020-05-06 | 993,981 | — | $0 | 993,981 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | P Buy | 2020-05-05 | 2020-05-06 | 413 | $16.00 | $6.6K | 7,274 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | P Buy | 2020-05-05 | 2020-05-06 | 603 | $16.00 | $9.6K | 10,618 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | P Buy | 2020-05-05 | 2020-05-06 | 1,176 | $16.00 | $18.8K | 20,701 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | P Buy | 2020-05-05 | 2020-05-06 | 60,308 | $16.00 | $964.9K | 1,062,259 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | S Sale | 2020-05-05 | 2020-05-06 | 64 | $16.00 | $1.0K | 6,861 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | X Exercise | 2020-05-05 | 2020-05-06 | 118 | $8.63 | $1.0K | 6,925 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | S Sale | 2020-05-05 | 2020-05-06 | 94 | $16.00 | $1.5K | 10,015 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | X Exercise | 2020-05-05 | 2020-05-06 | 173 | $8.63 | $1.5K | 10,109 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | S Sale | 2020-05-05 | 2020-05-06 | 182 | $16.00 | $2.9K | 19,525 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | X Exercise | 2020-05-05 | 2020-05-06 | 337 | $8.63 | $2.9K | 19,707 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | S Sale | 2020-05-05 | 2020-05-06 | 9,334 | $16.00 | $149.3K | 1,001,951 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | X Exercise | 2020-05-05 | 2020-05-06 | 17,304 | $8.63 | $149.3K | 1,011,285 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion | 2020-05-05 | 2020-05-06 | 6,807 | — | $0 | 6,807 | SEC↗ |
| MCGUIRE TERRANCE | 10% Owner | C Conversion | 2020-05-05 | 2020-05-06 | 9,936 | — | $0 | 9,936 | SEC↗ |
| LANGER ROBERT | Director | C Conversion | 2020-05-05 | 2020-05-06 | 668 | — | $0 | 15,167 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | X Exercise | 2020-05-05 | 2020-05-06 | 10,322 | $8.63 | $89.1K | 329,625 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | S Sale | 2020-05-05 | 2020-05-06 | 11,360 | $16.00 | $181.8K | 661,153 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | X Exercise | 2020-05-05 | 2020-05-06 | 21,060 | $8.63 | $181.7K | 672,513 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion | 2020-05-05 | 2020-05-06 | 471,929 | — | $0 | 471,929 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion | 2020-05-05 | 2020-05-06 | 319,303 | — | $0 | 319,303 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | C Conversion | 2020-05-05 | 2020-05-06 | 651,453 | — | $0 | 651,453 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | P Buy | 2020-05-05 | 2020-05-06 | 75,000 | $16.00 | $1.20M | 553,123 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | S Sale | 2020-05-05 | 2020-05-06 | 5,568 | $16.00 | $89.1K | 324,057 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | P Buy | 2020-05-05 | 2020-05-06 | 57,561 | $16.00 | $921.0K | 381,618 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | P Buy | 2020-05-05 | 2020-05-06 | 117,439 | $16.00 | $1.88M | 778,592 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | S Sale | 2020-05-05 | 2020-05-06 | 7,255 | $16.00 | $116.1K | 478,123 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | X Exercise | 2020-05-05 | 2020-05-06 | 13,449 | $8.63 | $116.1K | 485,378 | SEC↗ |
| Roberts Carmichael | 10% Owner | C Conversion | 2020-05-05 | 2020-05-06 | 415 | — | $0 | 58,414 | SEC↗ |
| POLARIS VENTURE PARTNERS IV LP | 10% Owner | C Conversion | 2020-05-05 | 2020-05-06 | 316,980 | — | $0 | 316,980 | SEC↗ |
| POLARIS VENTURE PARTNERS IV LP | 10% Owner | C Conversion | 2020-05-05 | 2020-05-06 | 5,940 | — | $0 | 5,940 | SEC↗ |
| WHITESIDES GEORGE M | Director | C Conversion | 2020-05-05 | 2020-05-06 | 6,404 | — | $0 | 55,064 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion | 2020-05-05 | 2020-05-06 | 651,453 | — | $0 | 651,453 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | S Sale | 2020-05-05 | 2020-05-06 | 5,568 | $16.00 | $89.1K | 324,057 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | X Exercise | 2020-05-05 | 2020-05-06 | 13,449 | $8.63 | $116.1K | 485,378 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | S Sale | 2020-05-05 | 2020-05-06 | 7,255 | $16.00 | $116.1K | 478,123 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | P Buy | 2020-05-05 | 2020-05-06 | 117,439 | $16.00 | $1.88M | 778,592 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | P Buy | 2020-05-05 | 2020-05-06 | 57,561 | $16.00 | $921.0K | 381,618 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion | 2020-05-05 | 2020-05-06 | 319,303 | — | $0 | 319,303 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | C Conversion | 2020-05-05 | 2020-05-06 | 471,929 | — | $0 | 471,929 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | X Exercise | 2020-05-05 | 2020-05-06 | 21,060 | $8.63 | $181.7K | 672,513 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | X Exercise | 2020-05-05 | 2020-05-06 | 10,322 | $8.63 | $89.1K | 329,625 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | S Sale | 2020-05-05 | 2020-05-06 | 11,360 | $16.00 | $181.8K | 661,153 | SEC↗ |
| DAMORE RICHARD A | 10% Owner | P Buy | 2020-05-05 | 2020-05-06 | 75,000 | $16.00 | $1.20M | 553,123 | SEC↗ |
| PERCEPTIVE ADVISORS LLC | Director, 10% Owner | F Tax w/h | 2020-05-05 | 2020-05-06 | 76,172 | $16.00 | $1.22M | 1,309,115 | SEC↗ |
| PERCEPTIVE ADVISORS LLC | Director, 10% Owner | X Exercise | 2020-05-05 | 2020-05-06 | 141,221 | $8.63 | $1.22M | 1,385,287 | SEC↗ |
| PERCEPTIVE ADVISORS LLC | Director, 10% Owner | C Conversion | 2020-05-05 | 2020-05-06 | 470,739 | — | $0 | 1,244,066 | SEC↗ |
| PERCEPTIVE ADVISORS LLC | Director, 10% Owner | C Conversion | 2020-05-05 | 2020-05-06 | 1,132,016 | — | $0 | 1,132,016 | SEC↗ |
| PERCEPTIVE ADVISORS LLC | Director, 10% Owner | F Tax w/h | 2020-05-05 | 2020-05-06 | 183,174 | $16.00 | $2.93M | 1,288,446 | SEC↗ |
| PERCEPTIVE ADVISORS LLC | Director, 10% Owner | X Exercise | 2020-05-05 | 2020-05-06 | 339,604 | $8.63 | $2.93M | 1,471,620 | SEC↗ |
| PERCEPTIVE ADVISORS LLC | Director, 10% Owner | C Conversion | 2020-05-05 | 2020-05-06 | 773,327 | — | $0 | 773,327 | SEC↗ |
| Soleus Capital Master Fund, L. | 10% Owner | X Exercise | 2020-05-05 | 2020-05-15 | 31,382 | $8.63 | $270.8K | 474,330 | SEC↗ |
| Soleus Capital Master Fund, L. | 10% Owner | C Conversion | 2020-05-05 | 2020-05-15 | 104,608 | — | $0 | 442,948 | SEC↗ |
| Soleus Capital Master Fund, L. | 10% Owner | C Conversion | 2020-05-05 | 2020-05-15 | 338,330 | — | $0 | 338,330 | SEC↗ |
| Soleus Capital Master Fund, L. | 10% Owner | P Buy | 2020-05-05 | 2020-05-15 | 155,000 | $16.00 | $2.48M | 155,000 | SEC↗ |
| Soleus Capital Master Fund, L. | 10% Owner | S Sale | 2020-05-05 | 2020-05-15 | 16,909 | $16.00 | $270.5K | 457,421 | SEC↗ |
| PERCEPTIVE LIFE SCIENCES MASTE | 10% Owner | P Buy | 2020-05-05 | 2020-05-29 | 625,000 | $16.00 | $10.00M | 1,934,115 | SEC↗ |
| WHITESIDES GEORGE M | Director | A Award | 2020-05-01 | 2020-05-01 | 19,661 | $16.00 | $314.6K | 48,660 | SEC↗ |
| Noyes Corinne | See Remarks | A Award deriv | 2020-04-30 | 2020-05-01 | 9,782 | — | $0 | 9,782 | SEC↗ |
| Edgerly-Pflug Laura | See Remarks | A Award deriv | 2020-04-30 | 2020-05-01 | 20,046 | — | $0 | 20,046 | SEC↗ |
| ANDERSON EDWARD T | Director, 10% Owner | A Award deriv | 2020-04-30 | 2020-05-01 | 14,500 | — | $0 | 14,500 | SEC↗ |
| Elsey R Don | CFO, Treasurer & Secretary | A Award deriv | 2020-04-30 | 2020-05-01 | 20,635 | — | $0 | 20,635 | SEC↗ |
| WHITESIDES GEORGE M | Director | A Award deriv | 2020-04-30 | 2020-05-01 | 14,500 | — | $0 | 14,500 | SEC↗ |
| LANGER ROBERT | Director | A Award deriv | 2020-04-30 | 2020-05-01 | 14,500 | — | $0 | 14,500 | SEC↗ |
| Palasis Maria | President & CEO | A Award deriv | 2020-04-30 | 2020-05-01 | 326,303 | — | $0 | 326,303 | SEC↗ |
| Poukalov Konstantin | Director | A Award deriv | 2020-04-30 | 2020-05-01 | 14,500 | — | $0 | 14,500 | SEC↗ |
| ALTMAN MICHAEL SETH | Director | A Award deriv | 2020-04-30 | 2020-05-01 | 14,500 | — | $0 | 14,500 | SEC↗ |
| PERCEPTIVE ADVISORS LLC | Director, 10% Owner | A Award deriv | 2020-04-30 | 2020-05-01 | 14,500 | — | $0 | 14,500 | SEC↗ |
| PERCEPTIVE ADVISORS LLC | Director, 10% Owner | A Award deriv | 2020-04-30 | 2020-05-01 | 14,500 | — | $0 | 14,500 | SEC↗ |