MAZE

Maze Therapeutics, Inc.CIK 1842295 ☆ Sign in to watch Congress trades

Open-mkt buys · 90d

—

0 trades · 0 insiders

Open-mkt sales · 90d

$8.56M

49 trades · 4 insiders

Net · 90d

$-8.56M

Insiders on file

AI insights for MAZE PRO

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AI insights for MAZE

Insider sentiment score with a plain-English explanation, conviction score on every buy, and how the stock performed 30 and 90 days after past insider buys.

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Daily buy vs sell · 90 days

■ Open-market buys (P) ■ Open-market sales (S) · daily dollar value by transaction date

Insiders

Insider	Role	Trades	Bought	Sold	Last trade
Dandekar Atul	CSBO	70	$0	$6.04M	2026-10-29
Bernstein Harold	President, R&D & CMO	76	$0	$10.85M	2026-10-01
Coloma Jason V	Chief Executive Officer, Director	42	$0	$8.61M	2026-10-01
Courtney Phillips	GC and Corp. Secretary	15	$0	$209.5K	2026-09-03
Kornowski Sophie	Director	2	$0	$0	2026-08-13
Johnson Paula A	Director	2	$0	$0	2026-08-13
Andrews Nancy C	Director	2	$0	$0	2026-06-08
Hoppenot Herve	Director	2	$0	$0	2026-06-08
Lim Jonathan E	Director	9	$0	$0	2026-06-08
SPIEGELMAN DANIEL K	Director	2	$0	$0	2026-06-08
SCHELLER RICHARD H	Director	3	$0	$464.0K	2026-06-08
HOMCY CHARLES J	Director	20	$0	$0	2026-06-08
Bachrodt Amy	SVP, Finance	40	$0	$1.56M	2026-04-01
Kumar Neil	Director	1	$0	$0	2026-03-27
Tahir Misbah	Chief Financial Officer	3	$0	$0	2026-03-02
Sohn Catherine A.	Director	11	$0	$1.15M	2026-01-07
Third Rock Ventures GP V, LP	10% Owner	1	$0	$0	2025-11-04
Kathiresan Sekar	Director	1	$0	$0	2025-09-22
Exter Neil	Director	2	$0	$0	2025-09-22
Third Rock Ventures IV, L.P.	10% Owner	5	$0	$0	2025-02-03

Trade history

Insider	Role	Code	Trade	Filed	Shares	Price	Value	Owned after
Dandekar Atul	CSBO	M Exercise deriv	2026-10-29	2026-10-30	857	—	$0	25,073	SEC↗
Dandekar Atul	CSBO	M Exercise deriv	2026-10-29	2026-10-30	6,643	—	$0	0	SEC↗
Dandekar Atul	CSBO	S Sale	2026-10-29	2026-10-30	7,500	$32.07	$240.5K	32,316	SEC↗
Dandekar Atul	CSBO	M Exercise	2026-10-29	2026-10-30	857	$10.42	$8.9K	39,816	SEC↗
Dandekar Atul	CSBO	M Exercise	2026-10-29	2026-10-30	6,643	$10.42	$69.2K	38,959	SEC↗
Coloma Jason V	Chief Executive Officer, Dir	S Sale	2026-10-01	2026-10-02	31,908	$27.02	$862.2K	191,447	SEC↗
Coloma Jason V	Chief Executive Officer, Dir	S Sale	2026-10-01	2026-10-02	2,593	$27.02	$70.1K	15,558	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise deriv	2026-10-01	2026-10-02	16,141	—	$0	144,521	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-10-01	2026-10-02	16,141	$26.93	$434.7K	0	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise	2026-10-01	2026-10-02	16,141	$10.42	$168.2K	16,141	SEC↗
Dandekar Atul	CSBO	M Exercise deriv	2026-09-29	2026-10-01	7,500	—	$0	6,643	SEC↗
Dandekar Atul	CSBO	S Sale	2026-09-29	2026-10-01	7,500	$27.06	$202.9K	32,316	SEC↗
Dandekar Atul	CSBO	M Exercise	2026-09-29	2026-10-01	7,500	$10.42	$78.2K	39,816	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-09-04	2026-09-08	9,705	$26.22	$254.5K	0	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-09-04	2026-09-08	9,705	$26.22	$254.5K	0	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-09-03	2026-09-04	5,130	$26.01	$133.4K	9,764	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-09-03	2026-09-04	59	$25.78	$1.5K	9,705	SEC↗
Coloma Jason V	Chief Executive Officer	S Sale	2026-09-03	2026-09-04	11,282	$26.01	$293.4K	27,491	SEC↗
Coloma Jason V	Chief Executive Officer	S Sale	2026-09-03	2026-09-04	129	$25.77	$3.3K	27,362	SEC↗
Dandekar Atul	CSBO	S Sale	2026-09-03	2026-09-04	36	$25.81	$929	32,316	SEC↗
Dandekar Atul	CSBO	S Sale	2026-09-03	2026-09-04	3,207	$26.01	$83.4K	32,352	SEC↗
Courtney Phillips	GC and Corp. Secretary	S Sale	2026-09-03	2026-09-04	22	$25.78	$567	7,007	SEC↗
Courtney Phillips	GC and Corp. Secretary	S Sale	2026-09-03	2026-09-04	1,990	$26.01	$51.8K	7,029	SEC↗
Dandekar Atul	CSBO	S Sale	2026-09-03	2026-09-04	36	$25.81	$929	32,316	SEC↗
Dandekar Atul	CSBO	S Sale	2026-09-03	2026-09-04	3,207	$26.01	$83.4K	32,352	SEC↗
Courtney Phillips	GC and Corp. Secretary	S Sale	2026-09-03	2026-09-04	22	$25.78	$567	7,007	SEC↗
Courtney Phillips	GC and Corp. Secretary	S Sale	2026-09-03	2026-09-04	1,990	$26.01	$51.8K	7,029	SEC↗
Coloma Jason V	Chief Executive Officer, Dir	S Sale	2026-09-03	2026-09-04	129	$25.77	$3.3K	27,362	SEC↗
Coloma Jason V	Chief Executive Officer, Dir	S Sale	2026-09-03	2026-09-04	11,282	$26.01	$293.5K	27,491	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-09-03	2026-09-04	59	$25.78	$1.5K	9,705	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-09-03	2026-09-04	5,130	$26.01	$133.4K	9,764	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-09-02	2026-09-04	4,481	$26.38	$118.2K	15,519	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-09-02	2026-09-04	625	$27.12	$16.9K	14,894	SEC↗
Coloma Jason V	Chief Executive Officer	S Sale	2026-09-02	2026-09-04	9,852	$26.38	$259.9K	40,148	SEC↗
Coloma Jason V	Chief Executive Officer	S Sale	2026-09-02	2026-09-04	1,375	$27.12	$37.3K	38,773	SEC↗
Dandekar Atul	CSBO	S Sale	2026-09-02	2026-09-04	391	$27.12	$10.6K	35,559	SEC↗
Dandekar Atul	CSBO	S Sale	2026-09-02	2026-09-04	2,800	$26.38	$73.9K	35,950	SEC↗
Courtney Phillips	GC and Corp. Secretary	S Sale	2026-09-02	2026-09-04	1,738	$26.38	$45.8K	9,262	SEC↗
Courtney Phillips	GC and Corp. Secretary	S Sale	2026-09-02	2026-09-04	243	$27.12	$6.6K	9,019	SEC↗
Dandekar Atul	CSBO	S Sale	2026-09-02	2026-09-04	391	$27.12	$10.6K	35,559	SEC↗
Dandekar Atul	CSBO	S Sale	2026-09-02	2026-09-04	2,800	$26.38	$73.9K	35,950	SEC↗
Courtney Phillips	GC and Corp. Secretary	S Sale	2026-09-02	2026-09-04	243	$27.12	$6.6K	9,019	SEC↗
Courtney Phillips	GC and Corp. Secretary	S Sale	2026-09-02	2026-09-04	1,738	$26.38	$45.8K	9,262	SEC↗
Coloma Jason V	Chief Executive Officer, Dir	S Sale	2026-09-02	2026-09-04	1,375	$27.12	$37.3K	38,773	SEC↗
Coloma Jason V	Chief Executive Officer, Dir	S Sale	2026-09-02	2026-09-04	9,852	$26.38	$259.9K	40,148	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-09-02	2026-09-04	625	$27.12	$17.0K	14,894	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-09-02	2026-09-04	4,481	$26.38	$118.2K	15,519	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise deriv	2026-09-01	2026-09-03	20,000	—	$0	20,000	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise deriv	2026-09-01	2026-09-03	16,141	—	$0	160,662	SEC↗
Coloma Jason V	Chief Executive Officer	M Exercise deriv	2026-09-01	2026-09-03	50,000	—	$0	50,000	SEC↗
Dandekar Atul	CSBO	M Exercise deriv	2026-09-01	2026-09-03	12,500	—	$0	12,500	SEC↗
Courtney Phillips	GC and Corp. Secretary	M Exercise deriv	2026-09-01	2026-09-03	11,000	—	$0	11,000	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise	2026-09-01	2026-09-03	20,000	—	$0	20,000	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-09-01	2026-09-03	16,141	$26.36	$425.5K	0	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise	2026-09-01	2026-09-03	16,141	$10.42	$168.2K	16,141	SEC↗
Coloma Jason V	Chief Executive Officer	S Sale	2026-09-01	2026-09-03	31,908	$26.29	$838.9K	223,355	SEC↗
Coloma Jason V	Chief Executive Officer	M Exercise	2026-09-01	2026-09-03	50,000	—	$0	50,000	SEC↗
Coloma Jason V	Chief Executive Officer	S Sale	2026-09-01	2026-09-03	2,593	$26.31	$68.2K	18,151	SEC↗
Dandekar Atul	CSBO	M Exercise	2026-09-01	2026-09-03	12,500	—	$0	38,750	SEC↗
Courtney Phillips	GC and Corp. Secretary	M Exercise	2026-09-01	2026-09-03	11,000	—	$0	11,000	SEC↗
Dandekar Atul	CSBO	M Exercise deriv	2026-09-01	2026-09-03	12,500	—	$0	12,500	SEC↗
Dandekar Atul	CSBO	M Exercise	2026-09-01	2026-09-03	12,500	—	$0	38,750	SEC↗
Courtney Phillips	GC and Corp. Secretary	M Exercise deriv	2026-09-01	2026-09-03	11,000	—	$0	11,000	SEC↗
Courtney Phillips	GC and Corp. Secretary	M Exercise	2026-09-01	2026-09-03	11,000	—	$0	11,000	SEC↗
Coloma Jason V	Chief Executive Officer, Dir	M Exercise deriv	2026-09-01	2026-09-03	50,000	—	$0	50,000	SEC↗
Coloma Jason V	Chief Executive Officer, Dir	M Exercise	2026-09-01	2026-09-03	50,000	—	$0	50,000	SEC↗
Coloma Jason V	Chief Executive Officer, Dir	S Sale	2026-09-01	2026-09-03	31,908	$26.29	$838.8K	223,355	SEC↗
Coloma Jason V	Chief Executive Officer, Dir	S Sale	2026-09-01	2026-09-03	2,593	$26.31	$68.2K	18,151	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise deriv	2026-09-01	2026-09-03	20,000	—	$0	20,000	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise deriv	2026-09-01	2026-09-03	16,141	—	$0	160,662	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise	2026-09-01	2026-09-03	20,000	—	$0	20,000	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-09-01	2026-09-03	16,141	$26.36	$425.5K	0	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise	2026-09-01	2026-09-03	16,141	$10.42	$168.2K	16,141	SEC↗
Dandekar Atul	CSBO	M Exercise deriv	2026-08-28	2026-08-31	7,500	—	$0	14,143	SEC↗
Dandekar Atul	CSBO	M Exercise	2026-08-28	2026-08-31	7,500	$10.42	$78.2K	33,750	SEC↗
Dandekar Atul	CSBO	S Sale	2026-08-28	2026-08-31	7,500	$27.58	$206.8K	26,250	SEC↗
Dandekar Atul	CSBO	M Exercise deriv	2026-08-28	2026-08-31	7,500	—	$0	14,143	SEC↗
Dandekar Atul	CSBO	S Sale	2026-08-28	2026-08-31	7,500	$27.58	$206.8K	26,250	SEC↗
Dandekar Atul	CSBO	M Exercise	2026-08-28	2026-08-31	7,500	$10.42	$78.2K	33,750	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise deriv	2026-08-13	2026-08-14	16,142	—	$0	176,803	SEC↗
Johnson Paula A	Director	A Award deriv	2026-08-13	2026-08-17	36,000	—	$0	36,000	SEC↗
Kornowski Sophie	Director	A Award deriv	2026-08-13	2026-08-17	36,000	—	$0	36,000	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise	2026-08-13	2026-08-14	16,142	$10.42	$168.2K	16,142	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-08-13	2026-08-14	16,142	$27.61	$445.7K	0	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise deriv	2026-08-13	2026-08-14	16,142	—	$0	176,803	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-08-13	2026-08-14	16,142	$27.61	$445.6K	0	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise	2026-08-13	2026-08-14	16,142	$10.42	$168.2K	16,142	SEC↗
Kornowski Sophie	Director	A Award deriv	2026-08-13	2026-08-17	36,000	—	$0	36,000	SEC↗
Johnson Paula A	Director	A Award deriv	2026-08-13	2026-08-17	36,000	—	$0	36,000	SEC↗
Coloma Jason V	Chief Executive Officer	S Sale	2026-08-03	2026-08-05	1,604	$27.09	$43.5K	255,263	SEC↗
Coloma Jason V	Chief Executive Officer	S Sale	2026-08-03	2026-08-05	30,304	$26.71	$809.4K	256,867	SEC↗
Coloma Jason V	Chief Executive Officer	S Sale	2026-08-03	2026-08-05	154	$27.09	$4.2K	20,744	SEC↗
Coloma Jason V	Chief Executive Officer	S Sale	2026-08-03	2026-08-05	2,439	$26.71	$65.1K	20,898	SEC↗
Coloma Jason V	Chief Executive Officer, Dir	S Sale	2026-08-03	2026-08-05	1,604	$27.09	$43.4K	255,263	SEC↗
Coloma Jason V	Chief Executive Officer, Dir	S Sale	2026-08-03	2026-08-05	30,304	$26.71	$809.5K	256,867	SEC↗
Coloma Jason V	Chief Executive Officer, Dir	S Sale	2026-08-03	2026-08-05	154	$27.09	$4.2K	20,744	SEC↗
Coloma Jason V	Chief Executive Officer, Dir	S Sale	2026-08-03	2026-08-05	2,439	$26.71	$65.2K	20,898	SEC↗
Dandekar Atul	CSBO	M Exercise deriv	2026-07-29	2026-07-31	7,500	—	$0	21,643	SEC↗
Dandekar Atul	CSBO	S Sale	2026-07-29	2026-07-31	7,100	$27.31	$193.9K	26,650	SEC↗
Dandekar Atul	CSBO	S Sale	2026-07-29	2026-07-31	400	$27.89	$11.2K	26,250	SEC↗
Dandekar Atul	CSBO	M Exercise	2026-07-29	2026-07-31	7,500	$10.42	$78.2K	33,750	SEC↗
Dandekar Atul	CSBO	M Exercise deriv	2026-07-29	2026-07-31	7,500	—	$0	21,643	SEC↗
Dandekar Atul	CSBO	S Sale	2026-07-29	2026-07-31	400	$27.89	$11.2K	26,250	SEC↗
Dandekar Atul	CSBO	S Sale	2026-07-29	2026-07-31	7,100	$27.31	$193.9K	26,650	SEC↗
Dandekar Atul	CSBO	M Exercise	2026-07-29	2026-07-31	7,500	$10.42	$78.2K	33,750	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise deriv	2026-07-01	2026-07-02	14,609	—	$0	192,945	SEC↗
Coloma Jason V	Chief Executive Officer	S Sale	2026-07-01	2026-07-02	30,311	$29.95	$907.8K	288,768	SEC↗
Coloma Jason V	Chief Executive Officer	S Sale	2026-07-01	2026-07-02	2,593	$29.98	$77.7K	23,337	SEC↗
Coloma Jason V	Chief Executive Officer	S Sale	2026-07-01	2026-07-02	1,597	$30.44	$48.6K	287,171	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-07-01	2026-07-02	13,409	$29.87	$400.5K	1,200	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise	2026-07-01	2026-07-02	14,609	$10.42	$152.2K	14,609	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-07-01	2026-07-02	1,200	$30.34	$36.4K	0	SEC↗
Dandekar Atul	CSBO	M Exercise deriv	2026-06-29	2026-07-01	7,500	—	$0	29,143	SEC↗
Dandekar Atul	CSBO	M Exercise	2026-06-29	2026-07-01	7,500	$10.42	$78.2K	33,750	SEC↗
Dandekar Atul	CSBO	S Sale	2026-06-29	2026-07-01	7,500	$28.02	$210.2K	26,250	SEC↗
Coloma Jason V	Chief Executive Officer	S Sale	2026-06-23	2026-06-24	23,865	$26.05	$621.7K	319,079	SEC↗
Coloma Jason V	Chief Executive Officer	S Sale	2026-06-22	2026-06-24	2,040	$26.00	$53.0K	25,930	SEC↗
Coloma Jason V	Chief Executive Officer	S Sale	2026-06-22	2026-06-24	1,953	$26.00	$50.8K	342,944	SEC↗
Andrews Nancy C	Director	A Award deriv	2026-06-08	2026-06-10	18,000	—	$0	18,000	SEC↗
HOMCY CHARLES J	Director	A Award deriv	2026-06-08	2026-06-10	18,000	—	$0	18,000	SEC↗
Hoppenot Herve	Director	A Award deriv	2026-06-08	2026-06-10	18,000	—	$0	18,000	SEC↗
Lim Jonathan E	Director	A Award deriv	2026-06-08	2026-06-10	18,000	—	$0	18,000	SEC↗
SCHELLER RICHARD H	Director	A Award deriv	2026-06-08	2026-06-10	18,000	—	$0	18,000	SEC↗
SPIEGELMAN DANIEL K	Director	A Award deriv	2026-06-08	2026-06-10	18,000	—	$0	18,000	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise deriv	2026-06-01	2026-06-03	14,853	—	$0	207,554	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-06-01	2026-06-03	13,253	$25.57	$338.9K	1,600	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise	2026-06-01	2026-06-03	14,853	$10.42	$154.8K	14,853	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-06-01	2026-06-03	1,600	$26.36	$42.2K	0	SEC↗
Coloma Jason V	Chief Executive Officer	S Sale	2026-06-01	2026-06-03	553	$26.24	$14.5K	27,970	SEC↗
Coloma Jason V	Chief Executive Officer	S Sale	2026-06-01	2026-06-03	6,090	$26.20	$159.6K	344,897	SEC↗
Dandekar Atul	CSBO	M Exercise deriv	2026-05-29	2026-06-02	7,500	—	$0	36,643	SEC↗
Dandekar Atul	CSBO	S Sale	2026-05-29	2026-06-02	7,500	$26.34	$197.6K	24,808	SEC↗
Dandekar Atul	CSBO	M Exercise	2026-05-29	2026-06-02	7,500	$10.42	$78.2K	32,308	SEC↗
Coloma Jason V	Chief Executive Officer	S Sale	2026-05-26	2026-05-27	25,582	$26.02	$665.6K	350,987	SEC↗
Coloma Jason V	Chief Executive Officer	S Sale	2026-05-22	2026-05-27	2,478	$26.00	$64.4K	28,523	SEC↗
Coloma Jason V	Chief Executive Officer	S Sale	2026-05-22	2026-05-27	4,504	$26.00	$117.1K	376,569	SEC↗
Coloma Jason V	Chief Executive Officer	S Sale	2026-05-15	2026-05-18	1,822	$26.00	$47.4K	381,073	SEC↗
Coloma Jason V	Chief Executive Officer	S Sale	2026-05-15	2026-05-18	116	$26.00	$3.0K	31,001	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise deriv	2026-05-14	2026-05-18	15,000	—	$0	222,407	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise	2026-05-14	2026-05-18	15,000	$10.42	$156.3K	15,000	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-05-14	2026-05-18	15,000	$26.22	$393.3K	0	SEC↗
Dandekar Atul	CSBO	M Exercise deriv	2026-05-04	2026-05-06	8,320	—	$0	20,204	SEC↗
Dandekar Atul	CSBO	M Exercise deriv	2026-05-04	2026-05-06	5,985	—	$0	27,725	SEC↗
HOMCY CHARLES J	Director	G Gift	2026-05-04	2026-05-06	7,422	—	$0	31,113	SEC↗
Dandekar Atul	CSBO	M Exercise	2026-05-04	2026-05-06	5,985	$10.42	$62.4K	24,808	SEC↗
Dandekar Atul	CSBO	M Exercise	2026-05-04	2026-05-06	8,320	$10.42	$86.7K	18,823	SEC↗
Dandekar Atul	CSBO	M Exercise deriv	2026-04-29	2026-05-01	7,500	—	$0	44,143	SEC↗
Dandekar Atul	CSBO	S Sale	2026-04-29	2026-05-01	7,500	$25.37	$190.3K	10,503	SEC↗
Dandekar Atul	CSBO	M Exercise	2026-04-29	2026-05-01	7,500	$10.42	$78.2K	18,003	SEC↗
Bachrodt Amy	SVP, Finance	M Exercise deriv	2026-04-01	2026-04-02	2,500	—	$0	33,833	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise deriv	2026-04-01	2026-04-02	15,000	—	$0	237,407	SEC↗
Bachrodt Amy	SVP, Finance	M Exercise	2026-04-01	2026-04-02	2,500	$10.42	$26.1K	15,465	SEC↗
Bachrodt Amy	SVP, Finance	S Sale	2026-04-01	2026-04-02	2,200	$29.32	$64.5K	13,265	SEC↗
Bachrodt Amy	SVP, Finance	S Sale	2026-04-01	2026-04-02	300	$30.34	$9.1K	12,965	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise	2026-04-01	2026-04-02	15,000	$10.42	$156.3K	15,000	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-04-01	2026-04-02	300	$31.07	$9.3K	0	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-04-01	2026-04-02	3,348	$30.06	$100.6K	300	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-04-01	2026-04-02	11,352	$29.24	$331.9K	3,648	SEC↗
Dandekar Atul	CSBO	M Exercise deriv	2026-03-30	2026-04-01	7,500	—	$0	51,643	SEC↗
Dandekar Atul	CSBO	M Exercise	2026-03-30	2026-04-01	7,500	$10.42	$78.2K	18,003	SEC↗
Dandekar Atul	CSBO	S Sale	2026-03-30	2026-04-01	790	$30.02	$23.7K	10,503	SEC↗
Dandekar Atul	CSBO	S Sale	2026-03-30	2026-04-01	6,710	$29.26	$196.3K	11,293	SEC↗
Kumar Neil	Director	A Award deriv	2026-03-27	2026-03-31	33,417	—	$0	33,417	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise deriv	2026-03-20	2026-03-20	15,000	—	$0	252,407	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-03-20	2026-03-20	5,044	$50.02	$252.3K	0	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise	2026-03-20	2026-03-20	15,000	$10.42	$156.3K	15,000	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-03-20	2026-03-20	3,795	$49.32	$187.2K	5,044	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-03-20	2026-03-20	6,161	$48.20	$297.0K	8,839	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise deriv	2026-03-10	2026-03-12	30,000	—	$0	267,407	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-03-10	2026-03-12	29,652	$50.45	$1.50M	348	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-03-10	2026-03-12	348	$51.02	$17.8K	0	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise	2026-03-10	2026-03-12	30,000	$10.42	$312.6K	30,000	SEC↗
Coloma Jason V	Chief Executive Officer	A Award deriv	2026-03-02	2026-03-03	75,000	—	$0	75,000	SEC↗
Coloma Jason V	Chief Executive Officer	A Award deriv	2026-03-02	2026-03-03	150,000	—	$0	150,000	SEC↗
Bachrodt Amy	SVP, Finance	A Award deriv	2026-03-02	2026-03-03	16,000	—	$0	16,000	SEC↗
Bachrodt Amy	SVP, Finance	A Award deriv	2026-03-02	2026-03-03	32,000	—	$0	32,000	SEC↗
Bachrodt Amy	SVP, Finance	M Exercise deriv	2026-03-02	2026-03-03	5,000	—	$0	36,333	SEC↗
Bernstein Harold	President, R&D & CMO	A Award deriv	2026-03-02	2026-03-03	24,000	—	$0	24,000	SEC↗
Bernstein Harold	President, R&D & CMO	A Award deriv	2026-03-02	2026-03-03	48,000	—	$0	48,000	SEC↗
Dandekar Atul	CSBO	A Award deriv	2026-03-02	2026-03-03	19,000	—	$0	19,000	SEC↗
Dandekar Atul	CSBO	A Award deriv	2026-03-02	2026-03-03	38,000	—	$0	38,000	SEC↗
Courtney Phillips	GC and Corp. Secretary	A Award deriv	2026-03-02	2026-03-03	32,000	—	$0	32,000	SEC↗
Courtney Phillips	GC and Corp. Secretary	A Award deriv	2026-03-02	2026-03-03	16,000	—	$0	16,000	SEC↗
Tahir Misbah	Chief Financial Officer	A Award deriv	2026-03-02	2026-03-03	20,000	—	$0	20,000	SEC↗
Tahir Misbah	Chief Financial Officer	A Award deriv	2026-03-02	2026-03-03	40,000	—	$0	40,000	SEC↗
Bachrodt Amy	SVP, Finance	S Sale	2026-03-02	2026-03-03	3,700	$45.47	$168.2K	12,965	SEC↗
Bachrodt Amy	SVP, Finance	S Sale	2026-03-02	2026-03-03	1,300	$44.44	$57.8K	16,665	SEC↗
Bachrodt Amy	SVP, Finance	M Exercise	2026-03-02	2026-03-03	5,000	$10.42	$52.1K	17,965	SEC↗
Dandekar Atul	CSBO	M Exercise deriv	2026-02-27	2026-03-03	7,500	—	$0	59,143	SEC↗
Dandekar Atul	CSBO	S Sale	2026-02-27	2026-03-03	3,739	$45.13	$168.7K	14,264	SEC↗
Dandekar Atul	CSBO	M Exercise	2026-02-27	2026-03-03	7,500	$10.42	$78.2K	18,003	SEC↗
Dandekar Atul	CSBO	S Sale	2026-02-27	2026-03-03	3,761	$45.72	$172.0K	10,503	SEC↗
Bachrodt Amy	SVP, Finance	M Exercise deriv	2026-02-02	2026-02-04	156	—	$0	41,333	SEC↗
Bachrodt Amy	SVP, Finance	M Exercise deriv	2026-02-02	2026-02-04	4,844	—	$0	3,025	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise deriv	2026-02-02	2026-02-04	15,000	—	$0	297,407	SEC↗
Bachrodt Amy	SVP, Finance	S Sale	2026-02-02	2026-02-04	200	$44.15	$8.8K	17,765	SEC↗
Bachrodt Amy	SVP, Finance	M Exercise	2026-02-02	2026-02-04	4,844	$10.42	$50.5K	17,809	SEC↗
Bachrodt Amy	SVP, Finance	M Exercise	2026-02-02	2026-02-04	156	$10.42	$1.6K	17,965	SEC↗
Bachrodt Amy	SVP, Finance	S Sale	2026-02-02	2026-02-04	4,064	$46.03	$187.1K	13,701	SEC↗
Bachrodt Amy	SVP, Finance	S Sale	2026-02-02	2026-02-04	736	$46.63	$34.3K	12,965	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-02-02	2026-02-04	5,936	$46.37	$275.3K	100	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-02-02	2026-02-04	100	$47.23	$4.7K	0	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-02-02	2026-02-04	8,364	$45.89	$383.8K	6,036	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-02-02	2026-02-04	600	$44.21	$26.5K	14,400	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise	2026-02-02	2026-02-04	15,000	$10.42	$156.3K	15,000	SEC↗
Dandekar Atul	CSBO	M Exercise deriv	2026-01-29	2026-02-02	7,500	—	$0	66,643	SEC↗
Dandekar Atul	CSBO	M Exercise	2026-01-29	2026-02-02	7,500	$10.42	$78.2K	18,003	SEC↗
Dandekar Atul	CSBO	S Sale	2026-01-29	2026-02-02	3,500	$44.04	$154.1K	13,303	SEC↗
Dandekar Atul	CSBO	S Sale	2026-01-29	2026-02-02	2,800	$45.01	$126.0K	10,503	SEC↗
Dandekar Atul	CSBO	S Sale	2026-01-29	2026-02-02	1,200	$43.18	$51.8K	16,803	SEC↗
Bachrodt Amy	SVP, Finance	M Exercise deriv	2026-01-22	2026-01-26	2,497	—	$0	486	SEC↗
Bachrodt Amy	SVP, Finance	M Exercise deriv	2026-01-22	2026-01-26	2,503	—	$0	7,869	SEC↗
Bachrodt Amy	SVP, Finance	M Exercise	2026-01-22	2026-01-26	2,497	$10.42	$26.0K	15,462	SEC↗
Bachrodt Amy	SVP, Finance	S Sale	2026-01-22	2026-01-26	5,000	$45.52	$227.6K	12,965	SEC↗
Bachrodt Amy	SVP, Finance	M Exercise	2026-01-22	2026-01-26	2,503	$10.42	$26.1K	17,965	SEC↗
Sohn Catherine A.	Director	M Exercise deriv	2026-01-07	2026-01-08	20,744	—	$0	0	SEC↗
Sohn Catherine A.	Director	M Exercise deriv	2026-01-07	2026-01-08	2,895	—	$0	316	SEC↗
Sohn Catherine A.	Director	M Exercise deriv	2026-01-07	2026-01-08	3,281	—	$0	5,805	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise deriv	2026-01-07	2026-01-09	25,156	—	$0	312,407	SEC↗
Sohn Catherine A.	Director	M Exercise	2026-01-07	2026-01-08	20,744	$10.42	$216.2K	20,744	SEC↗
Sohn Catherine A.	Director	M Exercise	2026-01-07	2026-01-08	2,895	$10.42	$30.2K	23,639	SEC↗
Sohn Catherine A.	Director	M Exercise	2026-01-07	2026-01-08	3,281	$10.42	$34.2K	26,920	SEC↗
Sohn Catherine A.	Director	S Sale	2026-01-07	2026-01-08	26,920	$39.11	$1.05M	0	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-01-07	2026-01-09	25,156	$40.20	$1.01M	0	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise	2026-01-07	2026-01-09	25,156	$10.42	$262.1K	25,156	SEC↗
Sohn Catherine A.	Director	M Exercise deriv	2026-01-06	2026-01-08	2,493	—	$0	3,211	SEC↗
Sohn Catherine A.	Director	M Exercise	2026-01-06	2026-01-08	2,493	$10.42	$26.0K	2,493	SEC↗
Sohn Catherine A.	Director	S Sale	2026-01-06	2026-01-08	2,493	$38.62	$96.3K	0	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise deriv	2026-01-05	2026-01-06	412	—	$0	337,563	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-01-05	2026-01-06	412	$40.00	$16.5K	0	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise	2026-01-05	2026-01-06	412	$10.42	$4.3K	412	SEC↗
Bachrodt Amy	SVP, Finance	M Exercise deriv	2026-01-02	2026-01-06	4,796	—	$0	2,983	SEC↗
Bachrodt Amy	SVP, Finance	M Exercise deriv	2026-01-02	2026-01-06	204	—	$0	2,377	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise deriv	2026-01-02	2026-01-06	4,432	—	$0	337,975	SEC↗
Bachrodt Amy	SVP, Finance	M Exercise	2026-01-02	2026-01-06	204	$10.42	$2.1K	13,169	SEC↗
Bachrodt Amy	SVP, Finance	S Sale	2026-01-02	2026-01-06	2,595	$39.57	$102.7K	12,965	SEC↗
Bachrodt Amy	SVP, Finance	S Sale	2026-01-02	2026-01-06	2,405	$38.70	$93.1K	15,560	SEC↗
Bachrodt Amy	SVP, Finance	M Exercise	2026-01-02	2026-01-06	4,796	$10.42	$50.0K	17,965	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2026-01-02	2026-01-06	4,432	$40.43	$179.2K	0	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise	2026-01-02	2026-01-06	4,432	$10.42	$46.2K	4,432	SEC↗
Bachrodt Amy	SVP, Finance	M Exercise deriv	2025-12-30	2025-12-31	2,605	—	$0	2,581	SEC↗
Bachrodt Amy	SVP, Finance	M Exercise deriv	2025-12-30	2025-12-31	2,395	—	$0	1	SEC↗
Dandekar Atul	CSBO	M Exercise deriv	2025-12-30	2025-12-31	100	—	$0	74,143	SEC↗
Bachrodt Amy	SVP, Finance	M Exercise	2025-12-30	2025-12-31	2,605	$10.42	$27.1K	17,965	SEC↗
Bachrodt Amy	SVP, Finance	S Sale	2025-12-30	2025-12-31	5,000	$40.08	$200.4K	12,965	SEC↗
Bachrodt Amy	SVP, Finance	M Exercise	2025-12-30	2025-12-31	2,395	$10.42	$25.0K	15,360	SEC↗
Dandekar Atul	CSBO	S Sale	2025-12-30	2025-12-31	100	$40.36	$4.0K	10,503	SEC↗
Dandekar Atul	CSBO	M Exercise	2025-12-30	2025-12-31	100	$10.42	$1.0K	10,603	SEC↗
Bachrodt Amy	SVP, Finance	M Exercise deriv	2025-12-29	2025-12-31	124	—	$0	2,396	SEC↗
Bachrodt Amy	SVP, Finance	M Exercise deriv	2025-12-29	2025-12-31	9,876	—	$0	23,834	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise deriv	2025-12-29	2025-12-31	45,000	—	$0	342,407	SEC↗
Dandekar Atul	CSBO	M Exercise deriv	2025-12-29	2025-12-31	72,400	—	$0	74,243	SEC↗
Bachrodt Amy	SVP, Finance	M Exercise	2025-12-29	2025-12-31	124	$10.42	$1.3K	13,089	SEC↗
Bachrodt Amy	SVP, Finance	M Exercise	2025-12-29	2025-12-31	9,876	$10.42	$102.9K	22,965	SEC↗
Bachrodt Amy	SVP, Finance	S Sale	2025-12-29	2025-12-31	9,400	$40.54	$381.1K	13,565	SEC↗
Bachrodt Amy	SVP, Finance	S Sale	2025-12-29	2025-12-31	600	$41.16	$24.7K	12,965	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2025-12-29	2025-12-31	27,800	$40.34	$1.12M	17,200	SEC↗
Bernstein Harold	President, R&D & CMO	M Exercise	2025-12-29	2025-12-31	45,000	$10.42	$468.9K	45,000	SEC↗
Bernstein Harold	President, R&D & CMO	S Sale	2025-12-29	2025-12-31	17,200	$40.93	$704.0K	0	SEC↗
Dandekar Atul	CSBO	M Exercise	2025-12-29	2025-12-31	72,400	$10.42	$754.4K	82,903	SEC↗
Dandekar Atul	CSBO	S Sale	2025-12-29	2025-12-31	66,365	$40.51	$2.69M	16,538	SEC↗
Dandekar Atul	CSBO	S Sale	2025-12-29	2025-12-31	6,035	$41.13	$248.2K	10,503	SEC↗
HOMCY CHARLES J	Director	J Other	2025-11-19	2025-11-21	1,489	—	$0	31,113	SEC↗
Third Rock Ventures GP V, LP	10% Owner	J Other	2025-11-04	2025-11-05	1,600,000	—	$0	4,473,958	SEC↗
HOMCY CHARLES J	Director	G Gift	2025-10-23	2025-10-27	28,423	—	$0	29,624	SEC↗
Hoppenot Herve	Director	A Award deriv	2025-10-06	2025-10-07	36,000	—	$0	36,000	SEC↗
Andrews Nancy C	Director	A Award deriv	2025-09-22	2025-09-24	18,000	—	$0	18,000	SEC↗
Exter Neil	Director	A Award deriv	2025-09-22	2025-09-24	18,000	—	$0	18,000	SEC↗
HOMCY CHARLES J	Director	A Award deriv	2025-09-22	2025-09-24	18,000	—	$0	18,000	SEC↗
Kathiresan Sekar	Director	A Award deriv	2025-09-22	2025-09-24	18,000	—	$0	18,000	SEC↗
Lim Jonathan E	Director	A Award deriv	2025-09-22	2025-09-24	18,000	—	$0	18,000	SEC↗
SCHELLER RICHARD H	Director	A Award deriv	2025-09-22	2025-09-24	18,000	—	$0	18,000	SEC↗
Sohn Catherine A.	Director	A Award deriv	2025-09-22	2025-09-24	18,000	—	$0	18,000	SEC↗
SPIEGELMAN DANIEL K	Director	A Award deriv	2025-09-22	2025-09-24	18,000	—	$0	18,000	SEC↗
Bachrodt Amy	SVP, Finance	A Award deriv	2025-09-22	2025-09-24	22,000	—	$0	22,000	SEC↗
Bernstein Harold	President, R&D & CMO	A Award deriv	2025-09-22	2025-09-24	40,000	—	$0	40,000	SEC↗
Coloma Jason V	Chief Executive Officer	A Award deriv	2025-09-22	2025-09-24	100,000	—	$0	100,000	SEC↗
Dandekar Atul	CSBO	A Award deriv	2025-09-22	2025-09-24	25,000	—	$0	25,000	SEC↗
Courtney Phillips	GC and Corp. Secretary	A Award deriv	2025-09-22	2025-09-24	22,000	—	$0	22,000	SEC↗
SCHELLER RICHARD H	Director	S Sale	2025-09-15	2025-09-16	20,744	$22.37	$464.0K	0	SEC↗
Tahir Misbah	Chief Financial Officer	A Award deriv	2025-09-02	2025-09-02	325,000	—	$0	325,000	SEC↗
Exter Neil	Director	A Award deriv	2025-08-17	2025-08-19	16,000	—	$0	16,000	SEC↗
HOMCY CHARLES J	Director	C Conversion deriv	2025-02-03	2025-02-04	71,564	—	$0	0	SEC↗
HOMCY CHARLES J	Director	C Conversion deriv	2025-02-03	2025-02-04	169,405	—	$0	0	SEC↗
HOMCY CHARLES J	Director	C Conversion deriv	2025-02-03	2025-02-04	72,727	—	$0	0	SEC↗
Lim Jonathan E	Director	C Conversion deriv	2025-02-03	2025-02-04	2,231,381	—	$0	0	SEC↗
Lim Jonathan E	Director	C Conversion deriv	2025-02-03	2025-02-04	363,703	—	$0	0	SEC↗
Third Rock Ventures IV, L.P.	10% Owner	C Conversion deriv	2025-02-03	2025-02-04	9,725,709	—	$0	0	SEC↗
Third Rock Ventures IV, L.P.	10% Owner	C Conversion deriv	2025-02-03	2025-02-04	9,166,666	—	$0	0	SEC↗
Third Rock Ventures IV, L.P.	10% Owner	C Conversion deriv	2025-02-03	2025-02-04	45,833,334	—	$0	0	SEC↗
HOMCY CHARLES J	Director	C Conversion	2025-02-03	2025-02-04	8,807	—	$0	37,330	SEC↗
HOMCY CHARLES J	Director	C Conversion	2025-02-03	2025-02-04	20,717	—	$0	58,047	SEC↗
HOMCY CHARLES J	Director	C Conversion	2025-02-03	2025-02-04	7,422	—	$0	7,422	SEC↗
Lim Jonathan E	Director	C Conversion	2025-02-03	2025-02-04	270,232	—	$0	307,956	SEC↗
Lim Jonathan E	Director	C Conversion	2025-02-03	2025-02-04	37,724	—	$0	37,724	SEC↗
Third Rock Ventures IV, L.P.	10% Owner	C Conversion	2025-02-03	2025-02-04	5,762,788	—	$0	6,073,958	SEC↗
Third Rock Ventures IV, L.P.	10% Owner	C Conversion	2025-02-03	2025-02-04	950,800	—	$0	950,800	SEC↗
HOMCY CHARLES J	Director	A Award deriv	2024-12-09	2025-02-04	0	—	$0	0	SEC↗
HOMCY CHARLES J	Director	D To issuer deriv	2024-12-09	2025-02-04	45,638	—	$0	45,638	SEC↗
HOMCY CHARLES J	Director	A Award deriv	2024-12-09	2025-02-04	46,675	—	$0	0	SEC↗