ONC

BeOne Medicines Ltd.CIK 1651308 ☆ Sign in to watch Congress trades

Open-mkt buys · 90d

—

0 trades · 0 insiders

Open-mkt sales · 90d

$247.13M

107 trades · 5 insiders

Net · 90d

$-247.13M

Insiders on file

AI insights for ONC PRO

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AI insights for ONC

Insider sentiment score with a plain-English explanation, conviction score on every buy, and how the stock performed 30 and 90 days after past insider buys.

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Daily buy vs sell · 90 days

■ Open-market buys (P) ■ Open-market sales (S) · daily dollar value by transaction date

Insiders

Insider	Role	Trades	Bought	Sold	Last trade
Wang Xiaodong	Director, Other	81	$0	$83.03M	2026-10-27
Lee Chan Henry	SVP, General Counsel	131	$0	$16.81M	2026-09-30
BAKER BROS. ADVISORS LP	Director	8	$0	$262.0K	2026-09-14
Ball Titus B.	Principal Accounting Officer	10	$0	$248.8K	2026-09-01
Wu Xiaobin	President and COO	59	$0	$37.62M	2026-08-25
OYLER JOHN	Chief Executive Officer, Director	193	$0	$433.94M	2026-08-12
Rosenberg Aaron	Chief Financial Officer	10	$0	$1.23M	2026-08-03
Wang Lai	President, Global Head of R&D	25	$0	$5.49M	2026-06-23
Mooney Elizabeth Fisher	Director	1	$0	$0	2026-06-11
Sawyers Charles Lazelle	Director	1	$0	$0	2026-06-11
Dugan Margaret	Director	2	$0	$65.6K	2026-06-11
Riva Alessandro	Director	2	$0	$65.6K	2026-06-11
BRANDICOURT OLIVIER	Director	1	$0	$0	2026-06-11
Sharp Shalini	Director	1	$0	$0	2026-06-11
Baker Brothers Life Sciences LP	Director	6	$0	$0	2026-06-11
HOOPER ANTHONY C	Director	1	$0	$0	2026-06-11
Yi Qingqing	Director	2	$0	$65.6K	2026-06-01
Sanders Corazon (Corsee) D.	Director	8	$0	$1.86M	2026-05-22
Baker Bros. Advisors (GP) LLC	Director	2	$0	$190.54M	2025-02-28

Trade history

Insider	Role	Code	Trade	Filed	Shares	Price	Value	Owned after
Wang Xiaodong	Director, Other	M Exercise deriv	2026-10-27	2026-10-29	403,364	—	$0	0	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-10-27	2026-10-29	6,903	$366.22	$2.53M	0	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-10-27	2026-10-29	3,965	$365.43	$1.45M	6,903	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-10-27	2026-10-29	2,841	$363.95	$1.03M	10,868	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-10-27	2026-10-29	8,148	$363.24	$2.96M	13,709	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-10-27	2026-10-29	2,331	$362.35	$844.6K	21,857	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-10-27	2026-10-29	320	$360.64	$115.4K	24,188	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-10-27	2026-10-29	1,280	$359.72	$460.4K	24,508	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-10-27	2026-10-29	1,681	$358.75	$603.1K	25,788	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-10-27	2026-10-29	1,239	$357.54	$443.0K	27,469	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-10-27	2026-10-29	1,440	$355.62	$512.1K	28,708	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-10-27	2026-10-29	880	$355.56	$312.9K	30,148	SEC↗
Wang Xiaodong	Director, Other	M Exercise	2026-10-27	2026-10-29	31,028	$36.90	$1.14M	31,028	SEC↗
Wang Xiaodong	Director, Other	M Exercise deriv	2026-10-13	2026-10-15	403,351	—	$0	403,364	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-10-13	2026-10-15	1,260	$353.24	$445.1K	0	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-10-13	2026-10-15	6,558	$352.57	$2.31M	1,260	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-10-13	2026-10-15	5,681	$351.40	$2.00M	7,818	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-10-13	2026-10-15	10,361	$350.47	$3.63M	13,499	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-10-13	2026-10-15	7,167	$349.56	$2.51M	23,860	SEC↗
Wang Xiaodong	Director, Other	M Exercise	2026-10-13	2026-10-15	31,027	$36.90	$1.14M	31,027	SEC↗
Lee Chan Henry	SVP, General Counsel	S Sale	2026-09-30	2026-10-02	1,115	$375.00	$418.1K	0	SEC↗
Wang Xiaodong	Director	M Exercise deriv	2026-09-28	2026-09-30	403,364	—	$0	806,715	SEC↗
Wang Xiaodong	Director	S Sale	2026-09-28	2026-09-30	4,239	$362.17	$1.54M	24,228	SEC↗
Wang Xiaodong	Director	S Sale	2026-09-28	2026-09-30	14,525	$366.58	$5.32M	738	SEC↗
Wang Xiaodong	Director	S Sale	2026-09-28	2026-09-30	2,047	$365.85	$748.9K	15,263	SEC↗
Wang Xiaodong	Director	S Sale	2026-09-28	2026-09-30	3,419	$364.07	$1.24M	17,310	SEC↗
Wang Xiaodong	Director	S Sale	2026-09-28	2026-09-30	3,499	$363.10	$1.27M	20,729	SEC↗
Wang Xiaodong	Director	S Sale	2026-09-28	2026-09-30	738	$367.23	$271.0K	0	SEC↗
Wang Xiaodong	Director	S Sale	2026-09-28	2026-09-30	2,241	$361.05	$809.1K	28,467	SEC↗
Wang Xiaodong	Director	S Sale	2026-09-28	2026-09-30	40	$359.16	$14.4K	30,708	SEC↗
Wang Xiaodong	Director	S Sale	2026-09-28	2026-09-30	120	$358.71	$43.0K	30,748	SEC↗
Wang Xiaodong	Director	S Sale	2026-09-28	2026-09-30	160	$356.97	$57.1K	30,868	SEC↗
Wang Xiaodong	Director	M Exercise	2026-09-28	2026-09-30	31,028	$36.90	$1.14M	31,028	SEC↗
Wang Xiaodong	Director, Other	M Exercise deriv	2026-09-28	2026-09-30	403,364	—	$0	806,715	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-09-28	2026-09-30	738	$367.23	$271.0K	0	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-09-28	2026-09-30	14,525	$366.58	$5.32M	738	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-09-28	2026-09-30	2,047	$365.85	$748.9K	15,263	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-09-28	2026-09-30	3,419	$364.07	$1.24M	17,310	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-09-28	2026-09-30	3,499	$363.10	$1.27M	20,729	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-09-28	2026-09-30	4,239	$362.17	$1.54M	24,228	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-09-28	2026-09-30	2,241	$361.05	$809.1K	28,467	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-09-28	2026-09-30	40	$359.16	$14.4K	30,708	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-09-28	2026-09-30	120	$358.71	$43.0K	30,748	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-09-28	2026-09-30	160	$356.97	$57.1K	30,868	SEC↗
Wang Xiaodong	Director, Other	M Exercise	2026-09-28	2026-09-30	31,028	$36.90	$1.14M	31,028	SEC↗
BAKER BROS. ADVISORS LP	Director	M Exercise deriv	2026-09-14	2026-09-16	30,768	—	$0	0	SEC↗
BAKER BROS. ADVISORS LP	Director	M Exercise deriv	2026-09-14	2026-09-16	30,768	—	$0	0	SEC↗
BAKER BROS. ADVISORS LP	Director	M Exercise	2026-09-14	2026-09-16	30,768	$36.83	$1.13M	761,410	SEC↗
BAKER BROS. ADVISORS LP	Director	M Exercise	2026-09-14	2026-09-16	30,768	$36.83	$1.13M	8,099,179	SEC↗
Wang Xiaodong	Director	M Exercise deriv	2026-09-08	2026-09-10	403,351	—	$0	1,210,079	SEC↗
Wang Xiaodong	Director	S Sale	2026-09-08	2026-09-10	6,278	$351.25	$2.21M	0	SEC↗
Wang Xiaodong	Director	S Sale	2026-09-08	2026-09-10	2,841	$346.16	$983.4K	3,238	SEC↗
Wang Xiaodong	Director	S Sale	2026-09-08	2026-09-10	1,517	$347.39	$527.0K	1,721	SEC↗
Wang Xiaodong	Director	S Sale	2026-09-08	2026-09-10	1,721	$348.01	$598.9K	0	SEC↗
Wang Xiaodong	Director	S Sale	2026-09-08	2026-09-10	6,569	$350.27	$2.30M	6,278	SEC↗
Wang Xiaodong	Director	S Sale	2026-09-08	2026-09-10	1,181	$345.38	$407.9K	6,079	SEC↗
Wang Xiaodong	Director	M Exercise	2026-09-08	2026-09-10	31,027	$36.90	$1.14M	31,027	SEC↗
Wang Xiaodong	Director	S Sale	2026-09-08	2026-09-10	7,492	$348.31	$2.61M	23,535	SEC↗
Wang Xiaodong	Director	S Sale	2026-09-08	2026-09-10	10,688	$349.28	$3.73M	12,847	SEC↗
Wang Xiaodong	Director, Other	M Exercise deriv	2026-09-08	2026-09-10	403,351	—	$0	1,210,079	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-09-08	2026-09-10	6,278	$351.25	$2.21M	0	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-09-08	2026-09-10	6,569	$350.27	$2.30M	6,278	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-09-08	2026-09-10	10,688	$349.28	$3.73M	12,847	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-09-08	2026-09-10	7,492	$348.31	$2.61M	23,535	SEC↗
Wang Xiaodong	Director, Other	M Exercise	2026-09-08	2026-09-10	31,027	$36.90	$1.14M	31,027	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-09-08	2026-09-10	1,721	$348.01	$598.9K	0	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-09-08	2026-09-10	1,517	$347.39	$527.0K	1,721	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-09-08	2026-09-10	2,841	$346.16	$983.4K	3,238	SEC↗
Wang Xiaodong	Director, Other	S Sale	2026-09-08	2026-09-10	1,181	$345.38	$407.9K	6,079	SEC↗
Ball Titus B.	Principal Accounting Officer	S Sale	2026-09-01	2026-09-03	132	$355.86	$47.0K	0	SEC↗
Ball Titus B.	Principal Accounting Officer	S Sale	2026-09-01	2026-09-03	132	$355.86	$47.0K	0	SEC↗
Wu Xiaobin	President and COO	S Sale	2026-08-25	2026-08-27	280	$380.00	$106.4K	0	SEC↗
Wu Xiaobin	President and COO	S Sale	2026-08-25	2026-08-27	280	$380.00	$106.4K	0	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-08-12	2026-08-12	20,899	$358.41	$7.49M	14,102	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-08-12	2026-08-12	15,396	$357.63	$5.51M	35,001	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-08-12	2026-08-12	2,515	$356.43	$896.4K	50,397	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-08-12	2026-08-12	1,980	$354.71	$702.3K	52,912	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-08-12	2026-08-12	14,102	$359.12	$5.06M	0	SEC↗
OYLER JOHN	Chief Executive Officer, Dir	S Sale	2026-08-12	2026-08-12	14,102	$359.12	$5.06M	0	SEC↗
OYLER JOHN	Chief Executive Officer, Dir	S Sale	2026-08-12	2026-08-12	20,899	$358.41	$7.49M	14,102	SEC↗
OYLER JOHN	Chief Executive Officer, Dir	S Sale	2026-08-12	2026-08-12	15,396	$357.63	$5.51M	35,001	SEC↗
OYLER JOHN	Chief Executive Officer, Dir	S Sale	2026-08-12	2026-08-12	2,515	$356.43	$896.4K	50,397	SEC↗
OYLER JOHN	Chief Executive Officer, Dir	S Sale	2026-08-12	2026-08-12	1,980	$354.71	$702.3K	52,912	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise deriv	2026-08-11	2026-08-13	10,556	—	$0	0	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise deriv	2026-08-11	2026-08-13	13,754	—	$0	57,369	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise deriv	2026-08-11	2026-08-13	10,348	—	$0	88,582	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-08-11	2026-08-12	4	$367.00	$1.5K	54,892	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-08-11	2026-08-12	1,200	$366.31	$439.6K	54,896	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-08-11	2026-08-12	3,176	$365.26	$1.16M	56,096	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-08-11	2026-08-12	5,211	$364.31	$1.90M	59,272	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-08-11	2026-08-12	13,403	$363.45	$4.87M	64,483	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-08-11	2026-08-12	11,568	$362.34	$4.19M	77,886	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-08-11	2026-08-12	14,569	$361.47	$5.27M	89,454	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-08-11	2026-08-12	8,081	$360.33	$2.91M	104,023	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-08-11	2026-08-12	13,695	$359.32	$4.92M	112,104	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise	2026-08-11	2026-08-13	812	$194.47	$157.9K	812	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise	2026-08-11	2026-08-13	1,058	$213.32	$225.7K	1,870	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise	2026-08-11	2026-08-13	796	$159.03	$126.6K	2,666	SEC↗
Lee Chan Henry	SVP, General Counsel	S Sale	2026-08-11	2026-08-13	2,666	$360.00	$959.8K	0	SEC↗
OYLER JOHN	Chief Executive Officer, Dir	S Sale	2026-08-11	2026-08-12	4	$367.00	$1.5K	54,892	SEC↗
OYLER JOHN	Chief Executive Officer, Dir	S Sale	2026-08-11	2026-08-12	1,200	$366.31	$439.6K	54,896	SEC↗
OYLER JOHN	Chief Executive Officer, Dir	S Sale	2026-08-11	2026-08-12	3,176	$365.26	$1.16M	56,096	SEC↗
OYLER JOHN	Chief Executive Officer, Dir	S Sale	2026-08-11	2026-08-12	5,211	$364.31	$1.90M	59,272	SEC↗
OYLER JOHN	Chief Executive Officer, Dir	S Sale	2026-08-11	2026-08-12	13,403	$363.45	$4.87M	64,483	SEC↗
OYLER JOHN	Chief Executive Officer, Dir	S Sale	2026-08-11	2026-08-12	11,568	$362.34	$4.19M	77,886	SEC↗
OYLER JOHN	Chief Executive Officer, Dir	S Sale	2026-08-11	2026-08-12	14,569	$361.47	$5.27M	89,454	SEC↗
OYLER JOHN	Chief Executive Officer, Dir	S Sale	2026-08-11	2026-08-12	8,081	$360.33	$2.91M	104,023	SEC↗
OYLER JOHN	Chief Executive Officer, Dir	S Sale	2026-08-11	2026-08-12	13,695	$359.32	$4.92M	112,104	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise deriv	2026-08-11	2026-08-13	10,348	—	$0	88,582	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise deriv	2026-08-11	2026-08-13	13,754	—	$0	57,369	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise deriv	2026-08-11	2026-08-13	10,556	—	$0	0	SEC↗
Lee Chan Henry	SVP, General Counsel	S Sale	2026-08-11	2026-08-13	2,666	$360.00	$959.8K	0	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise	2026-08-11	2026-08-13	796	$159.03	$126.6K	2,666	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise	2026-08-11	2026-08-13	1,058	$213.32	$225.7K	1,870	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise	2026-08-11	2026-08-13	812	$194.47	$157.9K	812	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-08-10	2026-08-12	2,813	$351.80	$989.6K	237,930	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-08-10	2026-08-12	3,680	$360.63	$1.33M	125,799	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-08-10	2026-08-12	21,254	$359.50	$7.64M	129,479	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-08-10	2026-08-12	45,044	$358.70	$16.16M	150,733	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-08-10	2026-08-12	15,869	$357.67	$5.68M	195,777	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-08-10	2026-08-12	12,418	$356.62	$4.43M	211,646	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-08-10	2026-08-12	3,476	$355.66	$1.24M	224,064	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-08-10	2026-08-12	6,717	$354.78	$2.38M	227,540	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-08-10	2026-08-12	3,673	$353.32	$1.30M	234,257	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-08-10	2026-08-12	67	$350.00	$23.4K	240,743	SEC↗
OYLER JOHN	Chief Executive Officer, Dir	S Sale	2026-08-10	2026-08-12	3,680	$360.63	$1.33M	125,799	SEC↗
OYLER JOHN	Chief Executive Officer, Dir	S Sale	2026-08-10	2026-08-12	21,254	$359.50	$7.64M	129,479	SEC↗
OYLER JOHN	Chief Executive Officer, Dir	S Sale	2026-08-10	2026-08-12	45,044	$358.70	$16.16M	150,733	SEC↗
OYLER JOHN	Chief Executive Officer, Dir	S Sale	2026-08-10	2026-08-12	15,869	$357.67	$5.68M	195,777	SEC↗
OYLER JOHN	Chief Executive Officer, Dir	S Sale	2026-08-10	2026-08-12	12,418	$356.62	$4.43M	211,646	SEC↗
OYLER JOHN	Chief Executive Officer, Dir	S Sale	2026-08-10	2026-08-12	3,476	$355.66	$1.24M	224,064	SEC↗
OYLER JOHN	Chief Executive Officer, Dir	S Sale	2026-08-10	2026-08-12	6,717	$354.78	$2.38M	227,540	SEC↗
OYLER JOHN	Chief Executive Officer, Dir	S Sale	2026-08-10	2026-08-12	3,673	$353.32	$1.30M	234,257	SEC↗
OYLER JOHN	Chief Executive Officer, Dir	S Sale	2026-08-10	2026-08-12	2,813	$351.80	$989.6K	237,930	SEC↗
OYLER JOHN	Chief Executive Officer, Dir	S Sale	2026-08-10	2026-08-12	67	$350.00	$23.4K	240,743	SEC↗
Rosenberg Aaron	Chief Financial Officer	S Sale	2026-08-03	2026-08-05	1,157	$312.72	$361.8K	0	SEC↗
Rosenberg Aaron	Chief Financial Officer	S Sale	2026-08-03	2026-08-05	1,157	$312.71	$361.8K	0	SEC↗
Lee Chan Henry	SVP, General Counsel	S Sale	2026-07-30	2026-08-03	1,044	$323.69	$337.9K	0	SEC↗
Lee Chan Henry	SVP, General Counsel	S Sale	2026-07-30	2026-08-03	1,044	$323.69	$337.9K	0	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise deriv	2026-07-22	2026-07-24	8,645	—	$0	71,123	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise deriv	2026-07-22	2026-07-24	6,370	—	$0	98,930	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise deriv	2026-07-22	2026-07-24	6,682	—	$0	10,556	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise	2026-07-22	2026-07-24	514	$194.47	$100.0K	514	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise	2026-07-22	2026-07-24	665	$213.32	$141.9K	1,179	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise	2026-07-22	2026-07-24	490	$159.03	$77.9K	1,669	SEC↗
Lee Chan Henry	SVP, General Counsel	S Sale	2026-07-22	2026-07-24	1,669	$325.00	$542.4K	0	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-21	2026-07-22	2,340	$320.06	$748.9K	0	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-21	2026-07-22	15,807	$319.29	$5.05M	2,340	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-21	2026-07-22	7,842	$318.41	$2.50M	18,147	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-21	2026-07-22	20,029	$316.91	$6.35M	25,989	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-21	2026-07-22	15,379	$316.26	$4.86M	46,018	SEC↗
OYLER JOHN	Chief Executive Officer	M Exercise deriv	2026-07-20	2026-07-22	441,870	—	$0	0	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-20	2026-07-22	6,273	$310.75	$1.95M	2,907	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-20	2026-07-22	2,907	$311.80	$906.4K	0	SEC↗
OYLER JOHN	Chief Executive Officer	M Exercise	2026-07-20	2026-07-22	33,990	$119.96	$4.08M	33,990	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-20	2026-07-22	5,146	$310.08	$1.60M	9,180	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-20	2026-07-22	280	$318.30	$89.1K	0	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-20	2026-07-22	523	$316.14	$165.3K	280	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-20	2026-07-22	1,512	$315.26	$476.7K	803	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-20	2026-07-22	1,850	$313.91	$580.7K	2,315	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-20	2026-07-22	14,326	$312.96	$4.48M	4,165	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-20	2026-07-22	15,499	$312.29	$4.84M	18,491	SEC↗
OYLER JOHN	Chief Executive Officer	M Exercise deriv	2026-07-17	2026-07-17	840,164	—	$0	441,870	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-17	2026-07-17	5,543	$311.42	$1.73M	51,535	SEC↗
OYLER JOHN	Chief Executive Officer	M Exercise	2026-07-17	2026-07-17	64,628	$119.96	$7.75M	64,628	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-17	2026-07-17	51	$315.06	$16.1K	0	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-17	2026-07-17	740	$314.32	$232.6K	51	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-17	2026-07-17	14,915	$313.19	$4.67M	791	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-17	2026-07-17	35,829	$312.17	$11.18M	15,706	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-17	2026-07-17	4,833	$310.37	$1.50M	57,078	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-17	2026-07-17	680	$309.05	$210.2K	61,911	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-17	2026-07-17	597	$306.96	$183.3K	62,591	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-17	2026-07-17	1,440	$305.20	$439.5K	63,188	SEC↗
OYLER JOHN	Chief Executive Officer	M Exercise deriv	2026-07-16	2026-07-17	911,248	—	$0	1,282,034	SEC↗
OYLER JOHN	Chief Executive Officer	M Exercise deriv	2026-07-16	2026-07-17	1,254,513	—	$0	0	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-16	2026-07-17	6,402	$318.55	$2.04M	50,791	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-16	2026-07-17	19,752	$316.00	$6.24M	132,215	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-16	2026-07-17	9,516	$314.73	$2.99M	151,967	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-16	2026-07-17	4,881	$314.08	$1.53M	161,483	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-16	2026-07-17	233	$311.98	$72.7K	166,364	SEC↗
OYLER JOHN	Chief Executive Officer	M Exercise	2026-07-16	2026-07-17	70,096	$119.96	$8.41M	166,597	SEC↗
OYLER JOHN	Chief Executive Officer	M Exercise	2026-07-16	2026-07-17	96,501	$160.40	$15.48M	96,501	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-16	2026-07-17	520	$323.59	$168.3K	0	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-16	2026-07-17	1,560	$322.71	$503.4K	520	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-16	2026-07-17	13,109	$321.61	$4.22M	2,080	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-16	2026-07-17	20,505	$321.00	$6.58M	15,189	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-16	2026-07-17	15,097	$319.99	$4.83M	35,694	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-16	2026-07-17	32,224	$316.82	$10.21M	99,991	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-16	2026-07-17	42,798	$317.79	$13.60M	57,193	SEC↗
OYLER JOHN	Chief Executive Officer	M Exercise deriv	2026-07-15	2026-07-17	462,865	—	$0	1	SEC↗
OYLER JOHN	Chief Executive Officer	M Exercise deriv	2026-07-15	2026-07-17	996,801	—	$0	9	SEC↗
OYLER JOHN	Chief Executive Officer	M Exercise deriv	2026-07-15	2026-07-17	55,575	—	$0	1,254,513	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-15	2026-07-17	7,640	$313.58	$2.40M	0	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-15	2026-07-17	48,657	$312.86	$15.22M	7,640	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-15	2026-07-17	12,857	$311.71	$4.01M	56,297	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-15	2026-07-17	41,336	$310.92	$12.85M	69,154	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-15	2026-07-17	6,067	$310.02	$1.88M	110,490	SEC↗
OYLER JOHN	Chief Executive Officer	M Exercise	2026-07-15	2026-07-17	4,275	$160.40	$685.7K	116,557	SEC↗
OYLER JOHN	Chief Executive Officer	M Exercise	2026-07-15	2026-07-17	76,677	$169.58	$13.00M	112,282	SEC↗
OYLER JOHN	Chief Executive Officer	M Exercise	2026-07-15	2026-07-17	35,605	$100.04	$3.56M	35,605	SEC↗
OYLER JOHN	Chief Executive Officer	M Exercise deriv	2026-07-14	2026-07-14	472,134	—	$0	462,866	SEC↗
OYLER JOHN	Chief Executive Officer	M Exercise deriv	2026-07-14	2026-07-14	1,264,666	—	$0	0	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-14	2026-07-14	39,090	$305.02	$11.92M	94,510	SEC↗
OYLER JOHN	Chief Executive Officer	M Exercise	2026-07-14	2026-07-14	36,318	$100.04	$3.63M	133,600	SEC↗
OYLER JOHN	Chief Executive Officer	M Exercise	2026-07-14	2026-07-14	97,282	$36.90	$3.59M	97,282	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-14	2026-07-14	45,895	$306.21	$14.05M	48,615	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-14	2026-07-14	40,781	$306.93	$12.52M	7,834	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-14	2026-07-14	7,834	$307.57	$2.41M	0	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-14	2026-07-14	8,122	$303.93	$2.47M	0	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-14	2026-07-14	4,139	$303.07	$1.25M	8,122	SEC↗
OYLER JOHN	Chief Executive Officer	M Exercise deriv	2026-07-13	2026-07-14	630,760	—	$0	1,264,666	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-13	2026-07-14	320	$307.41	$98.4K	0	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-13	2026-07-14	7,240	$306.82	$2.22M	320	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-13	2026-07-14	846	$305.57	$258.5K	7,560	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-13	2026-07-14	8,438	$304.68	$2.57M	8,406	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-13	2026-07-14	26,294	$303.83	$7.99M	16,844	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-13	2026-07-14	4,584	$302.79	$1.39M	43,138	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-13	2026-07-14	798	$301.94	$240.9K	47,722	SEC↗
OYLER JOHN	Chief Executive Officer	M Exercise	2026-07-13	2026-07-14	48,520	$36.90	$1.79M	48,520	SEC↗
OYLER JOHN	Chief Executive Officer	M Exercise deriv	2026-07-10	2026-07-14	152,074	—	$0	1,895,426	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-10	2026-07-14	1,493	$296.07	$442.0K	10,205	SEC↗
OYLER JOHN	Chief Executive Officer	M Exercise	2026-07-10	2026-07-14	11,698	$36.90	$431.7K	11,698	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-10	2026-07-14	370	$300.12	$111.0K	304	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-10	2026-07-14	1,314	$297.23	$390.6K	8,891	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-10	2026-07-14	18	$303.03	$5.5K	0	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-10	2026-07-14	136	$302.19	$41.1K	18	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-10	2026-07-14	150	$301.18	$45.2K	154	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-10	2026-07-14	3,074	$298.35	$917.1K	5,817	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-07-10	2026-07-14	5,143	$298.94	$1.54M	674	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise deriv	2026-07-08	2026-07-10	2,548	—	$0	105,300	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise deriv	2026-07-08	2026-07-10	2,626	—	$0	17,238	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise deriv	2026-07-08	2026-07-10	3,458	—	$0	79,768	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise	2026-07-08	2026-07-10	202	$194.47	$39.3K	202	SEC↗
Lee Chan Henry	SVP, General Counsel	S Sale	2026-07-08	2026-07-10	664	$302.46	$200.8K	0	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise	2026-07-08	2026-07-10	196	$159.03	$31.2K	664	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise	2026-07-08	2026-07-10	266	$213.32	$56.7K	468	SEC↗
Wang Lai	President, Global Head of R&	S Sale	2026-06-23	2026-06-25	1,068	$276.74	$295.6K	0	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-06-23	2026-06-25	1,800	$273.30	$491.9K	1,610	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-06-23	2026-06-25	320	$275.10	$88.0K	0	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-06-23	2026-06-25	1,290	$274.12	$353.6K	320	SEC↗
Wu Xiaobin	President and COO	S Sale	2026-06-23	2026-06-25	1,292	$276.26	$356.9K	0	SEC↗
Wang Lai	President, Global Head of R&	S Sale	2026-06-16	2026-06-18	1,169	$265.39	$310.2K	0	SEC↗
Lee Chan Henry	SVP, General Counsel	S Sale	2026-06-16	2026-06-18	590	$265.98	$156.9K	0	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-06-16	2026-06-18	333	$266.69	$88.8K	0	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-06-16	2026-06-18	1,650	$264.87	$437.0K	2,043	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-06-16	2026-06-18	1,710	$265.99	$454.8K	333	SEC↗
Wu Xiaobin	President and COO	S Sale	2026-06-16	2026-06-18	1,357	$266.76	$362.0K	0	SEC↗
Wang Xiaodong	Director	A Award deriv	2026-06-11	2026-06-15	193,492	—	$0	193,492	SEC↗
OYLER JOHN	Chief Executive Officer	A Award deriv	2026-06-11	2026-06-15	344,669	—	$0	344,669	SEC↗
Lee Chan Henry	SVP, General Counsel	A Award deriv	2026-06-11	2026-06-15	87,308	—	$0	87,308	SEC↗
Wu Xiaobin	President and COO	A Award deriv	2026-06-11	2026-06-15	229,775	—	$0	229,775	SEC↗
Rosenberg Aaron	Chief Financial Officer	A Award deriv	2026-06-11	2026-06-15	137,865	—	$0	137,865	SEC↗
Wang Lai	President, Global Head of R&	A Award deriv	2026-06-11	2026-06-15	229,775	—	$0	229,775	SEC↗
Baker Brothers Life Sciences L	Director	A Award	2026-06-11	2026-06-15	18,980	—	$0	161,546	SEC↗
Baker Brothers Life Sciences L	Director	A Award	2026-06-11	2026-06-15	18,980	—	$0	161,550	SEC↗
Riva Alessandro	Director	A Award	2026-06-11	2026-06-15	18,980	—	$0	73,164	SEC↗
Sharp Shalini	Director	A Award	2026-06-11	2026-06-15	18,980	—	$0	38,116	SEC↗
Sawyers Charles Lazelle	Director	A Award	2026-06-11	2026-06-15	18,980	—	$0	18,984	SEC↗
Dugan Margaret	Director	A Award	2026-06-11	2026-06-15	18,980	—	$0	73,164	SEC↗
Mooney Elizabeth Fisher	Director	A Award	2026-06-11	2026-06-15	18,980	—	$0	18,980	SEC↗
HOOPER ANTHONY C	Director	A Award	2026-06-11	2026-06-15	18,980	—	$0	83,720	SEC↗
BRANDICOURT OLIVIER	Director	A Award	2026-06-11	2026-06-15	18,980	—	$0	46,306	SEC↗
Wang Xiaodong	Director	A Award	2026-06-11	2026-06-15	99,892	—	$0	4,682,493	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-06-11	2026-06-15	149	$258.81	$38.6K	0	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-06-11	2026-06-15	200	$258.28	$51.7K	149	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-06-11	2026-06-15	859	$257.59	$221.3K	349	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-06-11	2026-06-15	741	$256.23	$189.9K	1,208	SEC↗
OYLER JOHN	Chief Executive Officer	A Award	2026-06-11	2026-06-15	177,931	—	$0	5,697,649	SEC↗
Lee Chan Henry	SVP, General Counsel	A Award	2026-06-11	2026-06-15	45,071	—	$0	346,554	SEC↗
Lee Chan Henry	SVP, General Counsel	S Sale	2026-06-11	2026-06-15	428	$257.64	$110.3K	0	SEC↗
Wu Xiaobin	President and COO	S Sale	2026-06-11	2026-06-15	626	$261.20	$163.5K	0	SEC↗
Wu Xiaobin	President and COO	A Award	2026-06-11	2026-06-15	118,625	—	$0	1,308,161	SEC↗
Rosenberg Aaron	Chief Financial Officer	S Sale	2026-06-11	2026-06-15	631	$257.74	$162.6K	0	SEC↗
Rosenberg Aaron	Chief Financial Officer	A Award	2026-06-11	2026-06-15	71,175	—	$0	397,891	SEC↗
Wang Lai	President, Global Head of R&	S Sale	2026-06-11	2026-06-15	756	$261.00	$197.3K	0	SEC↗
Wang Lai	President, Global Head of R&	A Award	2026-06-11	2026-06-15	118,625	—	$0	1,710,085	SEC↗
Ball Titus B.	Principal Accounting Officer	A Award	2026-06-11	2026-06-15	31,213	—	$0	99,645	SEC↗
Ball Titus B.	Principal Accounting Officer	S Sale	2026-06-11	2026-06-15	49	$256.39	$12.6K	120	SEC↗
Ball Titus B.	Principal Accounting Officer	S Sale	2026-06-11	2026-06-15	120	$257.53	$30.9K	0	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-06-08	2026-06-10	1,120	$271.14	$303.7K	0	SEC↗
OYLER JOHN	Chief Executive Officer	S Sale	2026-06-08	2026-06-10	3,820	$270.38	$1.03M	1,120	SEC↗
Wu Xiaobin	President and COO	S Sale	2026-06-08	2026-06-10	40	$270.55	$10.8K	0	SEC↗
Wu Xiaobin	President and COO	S Sale	2026-06-08	2026-06-10	1,444	$269.33	$388.9K	40	SEC↗
Wang Lai	President, Global Head of R&	S Sale	2026-06-08	2026-06-10	1,327	$269.34	$357.4K	40	SEC↗
Wang Lai	President, Global Head of R&	S Sale	2026-06-08	2026-06-10	40	$270.73	$10.8K	0	SEC↗
Lee Chan Henry	SVP, General Counsel	S Sale	2026-06-08	2026-06-10	160	$271.26	$43.4K	0	SEC↗
Lee Chan Henry	SVP, General Counsel	S Sale	2026-06-08	2026-06-10	711	$270.24	$192.1K	160	SEC↗
Ball Titus B.	Principal Accounting Officer	S Sale	2026-06-08	2026-06-10	100	$271.06	$27.1K	36	SEC↗
Ball Titus B.	Principal Accounting Officer	S Sale	2026-06-08	2026-06-10	36	$272.08	$9.8K	0	SEC↗
Yi Qingqing	Director	S Sale	2026-06-01	2026-06-03	235	$279.13	$65.6K	0	SEC↗
BAKER BROS. ADVISORS LP	Director	S Sale	2026-05-22	2026-05-27	2,756	$23.79	$65.6K	142,566	SEC↗
BAKER BROS. ADVISORS LP	Director	S Sale	2026-05-22	2026-05-27	2,756	$23.79	$65.6K	142,570	SEC↗
BAKER BROS. ADVISORS LP	Director	S Sale	2026-05-22	2026-05-27	2,743	$23.85	$65.4K	145,322	SEC↗
BAKER BROS. ADVISORS LP	Director	S Sale	2026-05-22	2026-05-27	2,743	$23.85	$65.4K	145,326	SEC↗
Sanders Corazon (Corsee) D.	Director	S Sale	2026-05-22	2026-05-27	212	$309.59	$65.6K	0	SEC↗
Dugan Margaret	Director	S Sale	2026-05-22	2026-05-27	212	$309.60	$65.6K	0	SEC↗
Riva Alessandro	Director	S Sale	2026-05-22	2026-05-27	212	$309.51	$65.6K	0	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise deriv	2026-05-13	2026-05-15	1,274	—	$0	107,848	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise deriv	2026-05-13	2026-05-15	1,729	—	$0	83,226	SEC↗
Lee Chan Henry	SVP, General Counsel	M Exercise deriv	2026-05-13	2026-05-15	1,313	—	$0	19,864	SEC↗