ONCE

Spark Therapeutics, Inc.CIK 1609351 ☆ Sign in to watch Congress trades

Open-mkt buys · 90d

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0 trades · 0 insiders

Open-mkt sales · 90d

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0 trades · 0 insiders

Net · 90d

Insiders on file

AI insights for ONCE PRO

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AI insights for ONCE

Insider sentiment score with a plain-English explanation, conviction score on every buy, and how the stock performed 30 and 90 days after past insider buys.

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Daily buy vs sell · 90 days

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Insiders

Insider	Role	Trades	Bought	Sold	Last trade
Dalton Lisa	Head of Human Resources	16	$0	$0	2019-12-17
Mingozzi Federico	Chief Scientific Officer	16	$0	$0	2019-12-17
Faga Daniel	Chief Business Officer	57	$0	$2.23M	2019-12-17
La Barge Joseph	See remarks	90	$0	$2.88M	2019-12-17
Marrazzo Jeffrey D	Chief Executive Officer	112	$0	$20.02M	2019-12-17
High Katherine A	See Remarks	98	$16.1K	$12.81M	2019-12-17
Mehra Anand	Director	67	$5.17M	$90.90M	2019-12-17
Altschuler Steven	Director	16	$245.6K	$0	2019-12-17
Webster Stephen W	Chief Financial Officer	51	$57.5K	$4.66M	2019-12-17
Ekman Lars	Director	14	$0	$0	2019-12-17
Zoth Lota S.	Director	15	$0	$0	2019-12-17
PEREZ ROBERT J	Director	12	$0	$0	2019-12-17
SIGAL ELLIOT	Director	21	$117.6K	$2.1K	2019-12-17
MILANO VINCENT	Director	14	$0	$0	2019-12-17
Children's Hospital of Philadelphia Foundation	Director, 10% Owner	19	$2.30M	$511.09M	2019-02-27
Furey John	Chief Operating Officer	17	$1.3K	$3.20M	2018-04-20
Betz Alert Lorris	Director	4	$0	$0	2017-05-31
Vivaldi Coelho Rogerio	Chief Commercial Officer	30	$57.5K	$3.81M	2016-07-15
Steel John	CEO	2	$0	$0	2012-01-10

Trade history

Insider	Role	Code	Trade	Filed	Shares	Price	Value	Owned after
La Barge Joseph	CHIEF LEGAL OFFICER	D To issuer deriv	2019-12-17	2019-12-17	11,250	—	$0	0	SEC↗
La Barge Joseph	CHIEF LEGAL OFFICER	D To issuer deriv	2019-12-17	2019-12-17	12,500	—	$0	0	SEC↗
La Barge Joseph	CHIEF LEGAL OFFICER	D To issuer deriv	2019-12-17	2019-12-17	21,000	—	$0	0	SEC↗
La Barge Joseph	CHIEF LEGAL OFFICER	D To issuer deriv	2019-12-17	2019-12-17	19,500	—	$0	0	SEC↗
La Barge Joseph	CHIEF LEGAL OFFICER	D To issuer deriv	2019-12-17	2019-12-17	35,000	—	$0	0	SEC↗
Altschuler Steven	Director	D To issuer deriv	2019-12-17	2019-12-17	4,000	—	$0	0	SEC↗
Altschuler Steven	Director	D To issuer deriv	2019-12-17	2019-12-17	6,000	—	$0	0	SEC↗
Altschuler Steven	Director	D To issuer deriv	2019-12-17	2019-12-17	37,203	—	$0	0	SEC↗
Altschuler Steven	Director	D To issuer deriv	2019-12-17	2019-12-17	4,000	—	$0	0	SEC↗
Ekman Lars	Director	D To issuer deriv	2019-12-17	2019-12-17	4,000	—	$0	0	SEC↗
Ekman Lars	Director	D To issuer deriv	2019-12-17	2019-12-17	37,203	—	$0	0	SEC↗
Ekman Lars	Director	D To issuer deriv	2019-12-17	2019-12-17	6,000	—	$0	0	SEC↗
Ekman Lars	Director	D To issuer deriv	2019-12-17	2019-12-17	4,000	—	$0	0	SEC↗
Faga Daniel	Chief Business Officer	D To issuer deriv	2019-12-17	2019-12-17	14,000	—	$0	0	SEC↗
Faga Daniel	Chief Business Officer	D To issuer deriv	2019-12-17	2019-12-17	35,000	—	$0	0	SEC↗
Faga Daniel	Chief Business Officer	D To issuer deriv	2019-12-17	2019-12-17	26,250	—	$0	0	SEC↗
Faga Daniel	Chief Business Officer	D To issuer deriv	2019-12-17	2019-12-17	21,500	—	$0	0	SEC↗
Faga Daniel	Chief Business Officer	D To issuer deriv	2019-12-17	2019-12-17	50,000	—	$0	0	SEC↗
High Katherine A	See Remarks	D To issuer deriv	2019-12-17	2019-12-17	35,000	—	$0	0	SEC↗
High Katherine A	See Remarks	D To issuer deriv	2019-12-17	2019-12-17	23,625	—	$0	0	SEC↗
High Katherine A	See Remarks	D To issuer deriv	2019-12-17	2019-12-17	15,750	—	$0	0	SEC↗
High Katherine A	See Remarks	D To issuer deriv	2019-12-17	2019-12-17	13,750	—	$0	0	SEC↗
High Katherine A	See Remarks	D To issuer deriv	2019-12-17	2019-12-17	21,250	—	$0	0	SEC↗
Marrazzo Jeffrey D	CHIEF EXECUTIVE OFFICER	D To issuer deriv	2019-12-17	2019-12-17	52,500	—	$0	0	SEC↗
Marrazzo Jeffrey D	CHIEF EXECUTIVE OFFICER	D To issuer deriv	2019-12-17	2019-12-17	49,250	—	$0	0	SEC↗
Marrazzo Jeffrey D	CHIEF EXECUTIVE OFFICER	D To issuer deriv	2019-12-17	2019-12-17	70,000	—	$0	0	SEC↗
Marrazzo Jeffrey D	CHIEF EXECUTIVE OFFICER	D To issuer deriv	2019-12-17	2019-12-17	135,000	—	$0	0	SEC↗
Marrazzo Jeffrey D	CHIEF EXECUTIVE OFFICER	D To issuer deriv	2019-12-17	2019-12-17	125,000	—	$0	0	SEC↗
Marrazzo Jeffrey D	CHIEF EXECUTIVE OFFICER	D To issuer deriv	2019-12-17	2019-12-17	126,131	—	$0	0	SEC↗
Marrazzo Jeffrey D	CHIEF EXECUTIVE OFFICER	D To issuer deriv	2019-12-17	2019-12-17	98,000	—	$0	0	SEC↗
Mingozzi Federico	CHIEF SCIENTIFIC OFFICER	D To issuer deriv	2019-12-17	2019-12-17	18,000	—	$0	0	SEC↗
Mingozzi Federico	CHIEF SCIENTIFIC OFFICER	D To issuer deriv	2019-12-17	2019-12-17	35,000	—	$0	0	SEC↗
Mingozzi Federico	CHIEF SCIENTIFIC OFFICER	D To issuer deriv	2019-12-17	2019-12-17	50,000	—	$0	0	SEC↗
Mingozzi Federico	CHIEF SCIENTIFIC OFFICER	D To issuer deriv	2019-12-17	2019-12-17	32,750	—	$0	0	SEC↗
Mehra Anand	Director	D To issuer deriv	2019-12-17	2019-12-17	4,000	—	$0	0	SEC↗
Mehra Anand	Director	D To issuer deriv	2019-12-17	2019-12-17	6,000	—	$0	0	SEC↗
Mehra Anand	Director	D To issuer deriv	2019-12-17	2019-12-17	4,000	—	$0	0	SEC↗
MILANO VINCENT	Director	D To issuer deriv	2019-12-17	2019-12-17	4,000	—	$0	0	SEC↗
MILANO VINCENT	Director	D To issuer deriv	2019-12-17	2019-12-17	4,000	—	$0	0	SEC↗
MILANO VINCENT	Director	D To issuer deriv	2019-12-17	2019-12-17	6,000	—	$0	0	SEC↗
MILANO VINCENT	Director	D To issuer deriv	2019-12-17	2019-12-17	37,203	—	$0	0	SEC↗
PEREZ ROBERT J	Director	D To issuer deriv	2019-12-17	2019-12-17	2,000	—	$0	0	SEC↗
PEREZ ROBERT J	Director	D To issuer deriv	2019-12-17	2019-12-17	8,000	—	$0	0	SEC↗
PEREZ ROBERT J	Director	D To issuer deriv	2019-12-17	2019-12-17	4,000	—	$0	0	SEC↗
SIGAL ELLIOT	Director	D To issuer deriv	2019-12-17	2019-12-17	25,786	—	$0	0	SEC↗
SIGAL ELLIOT	Director	D To issuer deriv	2019-12-17	2019-12-17	17,203	—	$0	0	SEC↗
SIGAL ELLIOT	Director	D To issuer deriv	2019-12-17	2019-12-17	6,000	—	$0	0	SEC↗
SIGAL ELLIOT	Director	D To issuer deriv	2019-12-17	2019-12-17	4,000	—	$0	0	SEC↗
SIGAL ELLIOT	Director	D To issuer deriv	2019-12-17	2019-12-17	4,000	—	$0	0	SEC↗
Webster Stephen W	CHIEF FINANCIAL OFFICER	D To issuer deriv	2019-12-17	2019-12-17	25,000	—	$0	0	SEC↗
Webster Stephen W	CHIEF FINANCIAL OFFICER	D To issuer deriv	2019-12-17	2019-12-17	28,000	—	$0	0	SEC↗
Webster Stephen W	CHIEF FINANCIAL OFFICER	D To issuer deriv	2019-12-17	2019-12-17	35,000	—	$0	0	SEC↗
Webster Stephen W	CHIEF FINANCIAL OFFICER	D To issuer deriv	2019-12-17	2019-12-17	60,000	—	$0	0	SEC↗
Webster Stephen W	CHIEF FINANCIAL OFFICER	D To issuer deriv	2019-12-17	2019-12-17	106,015	—	$0	0	SEC↗
Webster Stephen W	CHIEF FINANCIAL OFFICER	D To issuer deriv	2019-12-17	2019-12-17	19,500	—	$0	0	SEC↗
Webster Stephen W	CHIEF FINANCIAL OFFICER	D To issuer deriv	2019-12-17	2019-12-17	55,000	—	$0	0	SEC↗
Dalton Lisa	CHIEF HUMAN RESOURCE OFFICER	D To issuer deriv	2019-12-17	2019-12-17	28,000	—	$0	0	SEC↗
Dalton Lisa	CHIEF HUMAN RESOURCE OFFICER	D To issuer deriv	2019-12-17	2019-12-17	35,000	—	$0	0	SEC↗
Dalton Lisa	CHIEF HUMAN RESOURCE OFFICER	D To issuer deriv	2019-12-17	2019-12-17	19,500	—	$0	0	SEC↗
Dalton Lisa	CHIEF HUMAN RESOURCE OFFICER	D To issuer deriv	2019-12-17	2019-12-17	30,000	—	$0	0	SEC↗
Dalton Lisa	CHIEF HUMAN RESOURCE OFFICER	D To issuer deriv	2019-12-17	2019-12-17	28,389	—	$0	0	SEC↗
Dalton Lisa	CHIEF HUMAN RESOURCE OFFICER	D To issuer deriv	2019-12-17	2019-12-17	19,951	—	$0	0	SEC↗
Dalton Lisa	CHIEF HUMAN RESOURCE OFFICER	D To issuer deriv	2019-12-17	2019-12-17	20,325	—	$0	0	SEC↗
Zoth Lota S.	CHIEF SCIENTIFIC OFFICER	D To issuer deriv	2019-12-17	2019-12-17	6,000	—	$0	0	SEC↗
Zoth Lota S.	CHIEF SCIENTIFIC OFFICER	D To issuer deriv	2019-12-17	2019-12-17	12,000	—	$0	0	SEC↗
Zoth Lota S.	CHIEF SCIENTIFIC OFFICER	D To issuer deriv	2019-12-17	2019-12-17	4,000	—	$0	0	SEC↗
Zoth Lota S.	CHIEF SCIENTIFIC OFFICER	D To issuer deriv	2019-12-17	2019-12-17	4,000	—	$0	0	SEC↗
La Barge Joseph	CHIEF LEGAL OFFICER	U Tender	2019-12-17	2019-12-17	200	$114.50	$22.9K	0	SEC↗
La Barge Joseph	CHIEF LEGAL OFFICER	U Tender	2019-12-17	2019-12-17	50,193	$114.50	$5.75M	0	SEC↗
Altschuler Steven	Director	U Tender	2019-12-17	2019-12-17	28,000	$114.50	$3.21M	0	SEC↗
Ekman Lars	Director	U Tender	2019-12-17	2019-12-17	3,000	$114.50	$343.5K	0	SEC↗
Faga Daniel	Chief Business Officer	U Tender	2019-12-17	2019-12-17	38,828	$114.50	$4.45M	0	SEC↗
High Katherine A	See Remarks	U Tender	2019-12-17	2019-12-17	278,834	$114.50	$31.93M	0	SEC↗
Marrazzo Jeffrey D	CHIEF EXECUTIVE OFFICER	U Tender	2019-12-17	2019-12-17	355,215	$114.50	$40.67M	0	SEC↗
Mingozzi Federico	CHIEF SCIENTIFIC OFFICER	U Tender	2019-12-17	2019-12-17	12,615	$114.50	$1.44M	0	SEC↗
Mehra Anand	Director	U Tender	2019-12-17	2019-12-17	481,270	$114.50	$55.11M	0	SEC↗
Mehra Anand	Director	U Tender	2019-12-17	2019-12-17	40,203	$114.50	$4.60M	0	SEC↗
MILANO VINCENT	Director	U Tender	2019-12-17	2019-12-17	3,000	$114.50	$343.5K	0	SEC↗
PEREZ ROBERT J	Director	U Tender	2019-12-17	2019-12-17	2,500	$114.50	$286.3K	0	SEC↗
SIGAL ELLIOT	Director	U Tender	2019-12-17	2019-12-17	14,214	$114.50	$1.63M	0	SEC↗
Webster Stephen W	CHIEF FINANCIAL OFFICER	U Tender	2019-12-17	2019-12-17	6,102	$114.50	$698.7K	0	SEC↗
Dalton Lisa	CHIEF HUMAN RESOURCE OFFICER	U Tender	2019-12-17	2019-12-17	4,134	$114.50	$473.3K	0	SEC↗
Zoth Lota S.	CHIEF SCIENTIFIC OFFICER	U Tender	2019-12-17	2019-12-17	3,000	$114.50	$343.5K	0	SEC↗
Mingozzi Federico	Chief Scientific Officer	M Exercise deriv	2019-06-26	2019-06-27	8,375	—	$0	16,750	SEC↗
Mingozzi Federico	Chief Scientific Officer	F Tax w/h	2019-06-26	2019-06-27	2,775	$102.31	$283.9K	12,615	SEC↗
Mingozzi Federico	Chief Scientific Officer	M Exercise	2019-06-26	2019-06-27	8,375	—	$0	15,390	SEC↗
Altschuler Steven	Director	M Exercise deriv	2019-05-30	2019-06-03	1,500	—	$0	0	SEC↗
Ekman Lars	Director	M Exercise deriv	2019-05-30	2019-06-03	1,500	—	$0	0	SEC↗
MILANO VINCENT	Director	M Exercise deriv	2019-05-30	2019-06-03	1,500	—	$0	1,500	SEC↗
PEREZ ROBERT J	Director	M Exercise deriv	2019-05-30	2019-06-03	1,500	—	$0	0	SEC↗
SIGAL ELLIOT	Director	M Exercise deriv	2019-05-30	2019-06-03	1,500	—	$0	0	SEC↗
Zoth Lota S.	Director	M Exercise deriv	2019-05-30	2019-06-03	1,500	—	$0	0	SEC↗
Mehra Anand	Director	M Exercise deriv	2019-05-30	2019-06-03	1,500	—	$0	0	SEC↗
Altschuler Steven	Director	M Exercise	2019-05-30	2019-06-03	1,500	—	$0	28,000	SEC↗
Ekman Lars	Director	M Exercise	2019-05-30	2019-06-03	1,500	—	$0	3,000	SEC↗
MILANO VINCENT	Director	M Exercise	2019-05-30	2019-06-03	1,500	—	$0	3,000	SEC↗
PEREZ ROBERT J	Director	M Exercise	2019-05-30	2019-06-03	1,500	—	$0	2,500	SEC↗
SIGAL ELLIOT	Director	M Exercise	2019-05-30	2019-06-03	1,500	—	$0	14,214	SEC↗
Zoth Lota S.	Director	M Exercise	2019-05-30	2019-06-03	1,500	—	$0	3,000	SEC↗
Mehra Anand	Director	M Exercise	2019-05-30	2019-06-03	1,500	—	$0	40,203	SEC↗
Faga Daniel	Chief Business Officer	M Exercise deriv	2019-03-25	2019-03-27	80,000	—	$0	50,000	SEC↗
Faga Daniel	Chief Business Officer	M Exercise deriv	2019-03-25	2019-03-27	14,000	—	$0	14,000	SEC↗
Faga Daniel	Chief Business Officer	M Exercise deriv	2019-03-25	2019-03-27	8,750	—	$0	26,250	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise deriv	2019-03-25	2019-03-27	7,000	—	$0	21,000	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise deriv	2019-03-25	2019-03-27	12,500	—	$0	12,500	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise deriv	2019-03-25	2019-03-27	33,748	—	$0	11,250	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise deriv	2019-03-25	2019-03-27	41,755	—	$0	0	SEC↗
Faga Daniel	Chief Business Officer	F Tax w/h	2019-03-25	2019-03-27	10,325	$113.43	$1.17M	36,306	SEC↗
Faga Daniel	Chief Business Officer	M Exercise	2019-03-25	2019-03-27	14,000	$56.17	$786.4K	46,631	SEC↗
Faga Daniel	Chief Business Officer	F Tax w/h	2019-03-25	2019-03-27	6,228	$113.43	$706.4K	38,828	SEC↗
Faga Daniel	Chief Business Officer	M Exercise	2019-03-25	2019-03-27	80,000	$37.62	$3.01M	84,032	SEC↗
Faga Daniel	Chief Business Officer	M Exercise	2019-03-25	2019-03-27	8,750	$50.55	$442.3K	45,056	SEC↗
Faga Daniel	Chief Business Officer	F Tax w/h	2019-03-25	2019-03-27	51,401	$113.42	$5.83M	32,631	SEC↗
La Barge Joseph	Chief Legal Officer	F Tax w/h	2019-03-25	2019-03-27	21,260	$113.38	$2.41M	44,336	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise	2019-03-25	2019-03-27	7,000	$50.55	$353.9K	54,963	SEC↗
La Barge Joseph	Chief Legal Officer	F Tax w/h	2019-03-25	2019-03-27	8,873	$113.36	$1.01M	47,963	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise	2019-03-25	2019-03-27	12,500	$56.17	$702.1K	56,836	SEC↗
La Barge Joseph	Chief Legal Officer	F Tax w/h	2019-03-25	2019-03-27	4,770	$113.36	$540.7K	50,193	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise	2019-03-25	2019-03-27	33,748	$40.44	$1.36M	65,596	SEC↗
La Barge Joseph	Chief Legal Officer	F Tax w/h	2019-03-25	2019-03-27	31,389	$113.42	$3.56M	31,848	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise	2019-03-25	2019-03-27	41,755	$68.45	$2.86M	63,237	SEC↗
High Katherine A	See Remarks	M Exercise deriv	2019-03-21	2019-03-25	64,160	—	$0	0	SEC↗
High Katherine A	See Remarks	M Exercise deriv	2019-03-21	2019-03-25	15,750	—	$0	15,750	SEC↗
High Katherine A	See Remarks	M Exercise deriv	2019-03-21	2019-03-25	41,247	—	$0	13,750	SEC↗
High Katherine A	See Remarks	M Exercise deriv	2019-03-21	2019-03-25	7,875	—	$0	23,625	SEC↗
High Katherine A	See Remarks	M Exercise deriv	2019-03-21	2019-03-25	3	—	$0	54,997	SEC↗
High Katherine A	See Remarks	M Exercise deriv	2019-03-21	2019-03-25	5,840	—	$0	64,160	SEC↗
High Katherine A	See Remarks	M Exercise deriv	2019-03-21	2019-03-25	73,249	—	$0	0	SEC↗
High Katherine A	See Remarks	F Tax w/h	2019-03-21	2019-03-25	31,653	$113.25	$3.58M	256,064	SEC↗
High Katherine A	See Remarks	M Exercise	2019-03-21	2019-03-25	73,249	$3.45	$252.7K	287,717	SEC↗
High Katherine A	See Remarks	F Tax w/h	2019-03-21	2019-03-25	5,367	$113.26	$607.9K	278,834	SEC↗
High Katherine A	See Remarks	M Exercise	2019-03-21	2019-03-25	7,875	$50.55	$398.1K	284,201	SEC↗
High Katherine A	See Remarks	M Exercise	2019-03-21	2019-03-25	15,750	$56.17	$884.7K	287,510	SEC↗
High Katherine A	See Remarks	F Tax w/h	2019-03-21	2019-03-25	25,993	$113.26	$2.94M	271,760	SEC↗
High Katherine A	See Remarks	M Exercise	2019-03-21	2019-03-25	21,247	$40.44	$859.2K	297,753	SEC↗
High Katherine A	See Remarks	F Tax w/h	2019-03-21	2019-03-25	49,561	$113.26	$5.61M	276,506	SEC↗
High Katherine A	See Remarks	M Exercise	2019-03-21	2019-03-25	64,160	$68.45	$4.39M	326,067	SEC↗
High Katherine A	See Remarks	M Exercise	2019-03-21	2019-03-25	5,840	$68.45	$399.7K	261,904	SEC↗
High Katherine A	See Remarks	M Exercise	2019-03-21	2019-03-25	3	$40.44	$121	261,907	SEC↗
High Katherine A	See Remarks	F Tax w/h	2019-03-21	2019-03-25	11,184	$113.26	$1.27M	276,326	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise deriv	2019-03-19	2019-03-21	3,245	—	$0	0	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise deriv	2019-03-19	2019-03-21	8,683	—	$0	0	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise deriv	2019-03-19	2019-03-21	2	—	$0	2,473	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise deriv	2019-03-19	2019-03-21	629	—	$0	0	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise	2019-03-19	2019-03-21	629	$3.45	$2.2K	9,552	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise	2019-03-19	2019-03-21	2	$40.44	$81	21,482	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise	2019-03-19	2019-03-21	3,245	$68.45	$222.1K	21,480	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise	2019-03-19	2019-03-21	8,683	$3.45	$30.0K	18,235	SEC↗
Marrazzo Jeffrey D	Chief Executive Officer	M Exercise deriv	2019-03-15	2019-03-19	49,940	—	$0	126,131	SEC↗
Marrazzo Jeffrey D	Chief Executive Officer	M Exercise	2019-03-15	2019-03-19	49,940	$3.45	$172.3K	355,215	SEC↗
Children's Hospital of Philade	10% Owner	S Sale	2019-02-27	2019-03-01	2,000,000	$113.00	$226.00M	1,954,957	SEC↗
Faga Daniel	Chief Business Officer	M Exercise deriv	2019-01-18	2019-01-23	2,000	—	$0	4,000	SEC↗
Faga Daniel	Chief Business Officer	M Exercise deriv	2019-01-18	2019-01-23	2,500	—	$0	7,500	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise deriv	2019-01-18	2019-01-23	1,750	—	$0	3,500	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise deriv	2019-01-18	2019-01-23	2,000	—	$0	6,000	SEC↗
High Katherine A	See Remarks	M Exercise deriv	2019-01-18	2019-01-23	2,250	—	$0	4,500	SEC↗
High Katherine A	See Remarks	M Exercise deriv	2019-01-18	2019-01-23	2,250	—	$0	6,750	SEC↗
Dalton Lisa	Chief Human Resource Officer	M Exercise deriv	2019-01-18	2019-01-23	2,162	—	$0	4,325	SEC↗
Dalton Lisa	Chief Human Resource Officer	M Exercise deriv	2019-01-18	2019-01-23	2,000	—	$0	6,000	SEC↗
Marrazzo Jeffrey D	Chief Executive Officer	M Exercise deriv	2019-01-18	2019-01-23	5,000	—	$0	10,000	SEC↗
Marrazzo Jeffrey D	Chief Executive Officer	M Exercise deriv	2019-01-18	2019-01-23	3,750	—	$0	11,250	SEC↗
Webster Stephen W	Chief Financial Officer	M Exercise deriv	2019-01-18	2019-01-23	2,000	—	$0	6,000	SEC↗
Webster Stephen W	Chief Financial Officer	M Exercise deriv	2019-01-18	2019-01-23	1,750	—	$0	3,500	SEC↗
Mingozzi Federico	Chief Scientific Officer	M Exercise deriv	2019-01-18	2019-01-23	2,000	—	$0	6,000	SEC↗
Faga Daniel	Chief Business Officer	F Tax w/h	2019-01-18	2019-01-23	823	$45.08	$37.1K	4,032	SEC↗
Faga Daniel	Chief Business Officer	F Tax w/h	2019-01-18	2019-01-23	766	$45.08	$34.5K	2,355	SEC↗
Faga Daniel	Chief Business Officer	M Exercise	2019-01-18	2019-01-23	2,500	—	$0	4,855	SEC↗
Faga Daniel	Chief Business Officer	M Exercise	2019-01-18	2019-01-23	2,000	—	$0	3,121	SEC↗
La Barge Joseph	Chief Legal Officer	F Tax w/h	2019-01-18	2019-01-23	634	$45.08	$28.6K	7,556	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise	2019-01-18	2019-01-23	2,000	—	$0	9,556	SEC↗
La Barge Joseph	Chief Legal Officer	F Tax w/h	2019-01-18	2019-01-23	633	$45.08	$28.5K	8,923	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise	2019-01-18	2019-01-23	1,750	—	$0	8,190	SEC↗
High Katherine A	See Remarks	F Tax w/h	2019-01-18	2019-01-23	683	$45.08	$30.8K	214,468	SEC↗
High Katherine A	See Remarks	M Exercise	2019-01-18	2019-01-23	2,250	—	$0	215,151	SEC↗
High Katherine A	See Remarks	F Tax w/h	2019-01-18	2019-01-23	808	$45.08	$36.4K	212,901	SEC↗
High Katherine A	See Remarks	M Exercise	2019-01-18	2019-01-23	2,250	—	$0	213,709	SEC↗
Dalton Lisa	Chief Human Resource Officer	F Tax w/h	2019-01-18	2019-01-23	792	$45.08	$35.7K	2,755	SEC↗
Dalton Lisa	Chief Human Resource Officer	M Exercise	2019-01-18	2019-01-23	2,162	—	$0	3,547	SEC↗
Dalton Lisa	Chief Human Resource Officer	F Tax w/h	2019-01-18	2019-01-23	621	$45.08	$28.0K	4,134	SEC↗
Dalton Lisa	Chief Human Resource Officer	M Exercise	2019-01-18	2019-01-23	2,000	—	$0	4,755	SEC↗
Marrazzo Jeffrey D	Chief Executive Officer	F Tax w/h	2019-01-18	2019-01-23	1,174	$45.08	$52.9K	305,275	SEC↗
Marrazzo Jeffrey D	Chief Executive Officer	F Tax w/h	2019-01-18	2019-01-23	1,655	$45.08	$74.6K	302,699	SEC↗
Marrazzo Jeffrey D	Chief Executive Officer	M Exercise	2019-01-18	2019-01-23	5,000	—	$0	304,354	SEC↗
Marrazzo Jeffrey D	Chief Executive Officer	M Exercise	2019-01-18	2019-01-23	3,750	—	$0	306,449	SEC↗
Webster Stephen W	Chief Financial Officer	F Tax w/h	2019-01-18	2019-01-23	634	$45.08	$28.6K	4,731	SEC↗
Webster Stephen W	Chief Financial Officer	M Exercise	2019-01-18	2019-01-23	1,750	—	$0	5,365	SEC↗
Webster Stephen W	Chief Financial Officer	M Exercise	2019-01-18	2019-01-23	2,000	—	$0	6,731	SEC↗
Webster Stephen W	Chief Financial Officer	F Tax w/h	2019-01-18	2019-01-23	629	$45.08	$28.4K	6,102	SEC↗
Mingozzi Federico	Chief Scientific Officer	F Tax w/h	2019-01-18	2019-01-23	733	$45.08	$33.0K	7,015	SEC↗
Mingozzi Federico	Chief Scientific Officer	M Exercise	2019-01-18	2019-01-23	2,000	—	$0	7,748	SEC↗
Faga Daniel	Chief Business Officer	A Award deriv	2019-01-15	2019-01-17	35,000	—	$0	35,000	SEC↗
Faga Daniel	Chief Business Officer	A Award deriv	2019-01-15	2019-01-17	10,000	—	$0	10,000	SEC↗
High Katherine A	See Remarks	A Award deriv	2019-01-15	2019-01-17	10,000	—	$0	10,000	SEC↗
High Katherine A	See Remarks	A Award deriv	2019-01-15	2019-01-17	35,000	—	$0	35,000	SEC↗
Dalton Lisa	Head of Human Resources	A Award deriv	2019-01-15	2019-01-17	10,000	—	$0	10,000	SEC↗
Dalton Lisa	Head of Human Resources	A Award deriv	2019-01-15	2019-01-17	35,000	—	$0	35,000	SEC↗
Marrazzo Jeffrey D	Chief Executive Officer	A Award deriv	2019-01-15	2019-01-17	28,000	—	$0	28,000	SEC↗
Marrazzo Jeffrey D	Chief Executive Officer	A Award deriv	2019-01-15	2019-01-17	98,000	—	$0	98,000	SEC↗
Webster Stephen W	Chief Financial Officer	A Award deriv	2019-01-15	2019-01-17	10,000	—	$0	10,000	SEC↗
Webster Stephen W	Chief Financial Officer	A Award deriv	2019-01-15	2019-01-17	35,000	—	$0	35,000	SEC↗
La Barge Joseph	Chief Legal Officer	A Award deriv	2019-01-15	2019-01-17	35,000	—	$0	35,000	SEC↗
La Barge Joseph	Chief Legal Officer	A Award deriv	2019-01-15	2019-01-17	10,000	—	$0	10,000	SEC↗
Mingozzi Federico	Chief Scientific Officer	A Award deriv	2019-01-15	2019-01-17	10,000	—	$0	10,000	SEC↗
Mingozzi Federico	Chief Scientific Officer	A Award deriv	2019-01-15	2019-01-17	35,000	—	$0	35,000	SEC↗
Mehra Anand	Director	M Exercise deriv	2019-01-04	2019-01-08	37,203	—	$0	0	SEC↗
Mehra Anand	Director	M Exercise	2019-01-04	2019-01-08	37,203	$3.45	$128.4K	38,703	SEC↗
PEREZ ROBERT J	Director	M Exercise deriv	2019-01-03	2019-01-04	1,000	—	$0	2,000	SEC↗
PEREZ ROBERT J	Director	M Exercise	2019-01-03	2019-01-04	1,000	—	$0	1,000	SEC↗
Marrazzo Jeffrey D	Chief Executive Officer	M Exercise deriv	2018-12-28	2019-01-02	6,000	—	$0	176,071	SEC↗
Marrazzo Jeffrey D	Chief Executive Officer	M Exercise	2018-12-28	2019-01-02	6,000	$3.45	$20.7K	299,354	SEC↗
Mingozzi Federico	Chief Scientific Officer	M Exercise deriv	2018-06-26	2019-01-23	8,375	—	$0	25,125	SEC↗
Mingozzi Federico	Chief Scientific Officer	F Tax w/h	2018-06-26	2019-01-23	2,627	$87.98	$231.1K	5,748	SEC↗
Mingozzi Federico	Chief Scientific Officer	M Exercise	2018-06-26	2019-01-23	8,375	—	$0	8,375	SEC↗
Zoth Lota S.	Director	M Exercise deriv	2018-05-31	2018-05-31	1,500	—	$0	0	SEC↗
SIGAL ELLIOT	Director	M Exercise deriv	2018-05-31	2018-05-31	1,500	—	$0	0	SEC↗
Ekman Lars	Director	M Exercise deriv	2018-05-31	2018-05-31	1,500	—	$0	0	SEC↗
Altschuler Steven	Director	M Exercise deriv	2018-05-31	2018-05-31	1,500	—	$0	0	SEC↗
MILANO VINCENT	Director	M Exercise deriv	2018-05-31	2018-05-31	1,500	—	$0	0	SEC↗
Mehra Anand	Director	M Exercise deriv	2018-05-31	2018-06-01	1,500	—	$0	0	SEC↗
Zoth Lota S.	Director	M Exercise	2018-05-31	2018-05-31	1,500	—	$0	1,500	SEC↗
SIGAL ELLIOT	Director	M Exercise	2018-05-31	2018-05-31	1,500	—	$0	12,714	SEC↗
Ekman Lars	Director	M Exercise	2018-05-31	2018-05-31	1,500	—	$0	1,500	SEC↗
Altschuler Steven	Director	M Exercise	2018-05-31	2018-05-31	1,500	—	$0	26,500	SEC↗
MILANO VINCENT	Director	M Exercise	2018-05-31	2018-05-31	1,500	—	$0	1,500	SEC↗
Mehra Anand	Director	M Exercise	2018-05-31	2018-06-01	1,500	—	$0	1,500	SEC↗
Zoth Lota S.	Director	A Award deriv	2018-05-30	2018-05-31	4,000	—	$0	4,000	SEC↗
Zoth Lota S.	Director	A Award deriv	2018-05-30	2018-05-31	1,500	—	$0	1,500	SEC↗
SIGAL ELLIOT	Director	A Award deriv	2018-05-30	2018-05-31	4,000	—	$0	4,000	SEC↗
SIGAL ELLIOT	Director	A Award deriv	2018-05-30	2018-05-31	1,500	—	$0	1,500	SEC↗
Ekman Lars	Director	A Award deriv	2018-05-30	2018-05-31	1,500	—	$0	1,500	SEC↗
Ekman Lars	Director	A Award deriv	2018-05-30	2018-05-31	4,000	—	$0	4,000	SEC↗
Altschuler Steven	Director	A Award deriv	2018-05-30	2018-05-31	4,000	—	$0	4,000	SEC↗
Altschuler Steven	Director	A Award deriv	2018-05-30	2018-05-31	1,500	—	$0	1,500	SEC↗
MILANO VINCENT	Director	A Award deriv	2018-05-30	2018-05-31	4,000	—	$0	4,000	SEC↗
MILANO VINCENT	Director	A Award deriv	2018-05-30	2018-05-31	1,500	—	$0	1,500	SEC↗
PEREZ ROBERT J	Director	A Award deriv	2018-05-30	2018-06-01	4,000	—	$0	4,000	SEC↗
PEREZ ROBERT J	Director	A Award deriv	2018-05-30	2018-06-01	1,500	—	$0	1,500	SEC↗
Mehra Anand	Director	A Award deriv	2018-05-30	2018-06-01	4,000	—	$0	4,000	SEC↗
Mehra Anand	Director	A Award deriv	2018-05-30	2018-06-01	1,500	—	$0	1,500	SEC↗
Furey John	Chief Operating Officer	M Exercise deriv	2018-04-20	2018-04-24	6,723	—	$0	120,000	SEC↗
Furey John	Chief Operating Officer	S Sale	2018-04-20	2018-04-24	6,723	$82.50	$554.6K	0	SEC↗
Furey John	Chief Operating Officer	M Exercise	2018-04-20	2018-04-24	6,723	$49.74	$334.4K	6,723	SEC↗
Furey John	Chief Operating Officer	M Exercise deriv	2018-04-18	2018-04-19	11,000	—	$0	126,723	SEC↗
Furey John	Chief Operating Officer	S Sale	2018-04-18	2018-04-19	11,000	$82.53	$907.8K	0	SEC↗
Furey John	Chief Operating Officer	M Exercise	2018-04-18	2018-04-19	11,000	$49.74	$547.1K	11,000	SEC↗
Furey John	Chief Operating Officer	M Exercise deriv	2018-04-17	2018-04-19	2,277	—	$0	137,723	SEC↗
Furey John	Chief Operating Officer	S Sale	2018-04-17	2018-04-19	2,277	$82.50	$187.9K	0	SEC↗
Furey John	Chief Operating Officer	M Exercise	2018-04-17	2018-04-19	2,277	$49.74	$113.3K	2,277	SEC↗
Furey John	Chief Operating Officer	M Exercise deriv	2018-04-12	2018-04-16	20,000	—	$0	140,000	SEC↗
Furey John	Chief Operating Officer	S Sale	2018-04-12	2018-04-16	20,000	$77.51	$1.55M	0	SEC↗
Furey John	Chief Operating Officer	M Exercise	2018-04-12	2018-04-16	20,000	$49.74	$994.8K	20,000	SEC↗
La Barge Joseph	Chief Legal Officer	A Award deriv	2018-01-18	2018-01-22	28,000	—	$0	28,000	SEC↗
La Barge Joseph	Chief Legal Officer	A Award deriv	2018-01-18	2018-01-22	8,000	—	$0	8,000	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise deriv	2018-01-18	2018-01-22	1,750	—	$0	5,250	SEC↗
Faga Daniel	Chief Business Officer	A Award deriv	2018-01-18	2018-01-22	10,000	—	$0	10,000	SEC↗
Faga Daniel	Chief Business Officer	M Exercise deriv	2018-01-18	2018-01-22	2,000	—	$0	6,000	SEC↗
Faga Daniel	Chief Business Officer	A Award deriv	2018-01-18	2018-01-22	35,000	—	$0	35,000	SEC↗
High Katherine A	See Remarks	M Exercise deriv	2018-01-18	2018-01-22	2,250	—	$0	6,750	SEC↗
High Katherine A	See Remarks	A Award deriv	2018-01-18	2018-01-22	9,000	—	$0	9,000	SEC↗
High Katherine A	See Remarks	A Award deriv	2018-01-18	2018-01-22	31,500	—	$0	31,500	SEC↗
Furey John	Chief Operating Officer	A Award deriv	2018-01-18	2018-01-22	17,500	—	$0	17,500	SEC↗
Furey John	Chief Operating Officer	A Award deriv	2018-01-18	2018-01-22	35,000	—	$0	35,000	SEC↗
Marrazzo Jeffrey D	Chief Executive Officer	A Award deriv	2018-01-18	2018-01-22	15,000	—	$0	15,000	SEC↗
Marrazzo Jeffrey D	Chief Executive Officer	M Exercise deriv	2018-01-18	2018-01-22	5,000	—	$0	15,000	SEC↗
Marrazzo Jeffrey D	Chief Executive Officer	A Award deriv	2018-01-18	2018-01-22	52,500	—	$0	52,500	SEC↗
Webster Stephen W	Chief Financial Officer	A Award deriv	2018-01-18	2018-01-22	28,000	—	$0	28,000	SEC↗
Webster Stephen W	Chief Financial Officer	M Exercise deriv	2018-01-18	2018-01-22	1,750	—	$0	5,250	SEC↗
Webster Stephen W	Chief Financial Officer	A Award deriv	2018-01-18	2018-01-22	8,000	—	$0	8,000	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise	2018-01-18	2018-01-22	1,750	—	$0	7,075	SEC↗
La Barge Joseph	Chief Legal Officer	F Tax w/h	2018-01-18	2018-01-22	635	$50.55	$32.1K	6,440	SEC↗
Faga Daniel	Chief Business Officer	F Tax w/h	2018-01-18	2018-01-22	879	$50.55	$44.4K	1,121	SEC↗
Faga Daniel	Chief Business Officer	M Exercise	2018-01-18	2018-01-22	2,000	—	$0	2,000	SEC↗
High Katherine A	See Remarks	F Tax w/h	2018-01-18	2018-01-22	791	$50.55	$40.0K	211,459	SEC↗
High Katherine A	See Remarks	M Exercise	2018-01-18	2018-01-22	2,250	—	$0	212,250	SEC↗
Marrazzo Jeffrey D	Chief Executive Officer	M Exercise	2018-01-18	2018-01-22	5,000	—	$0	295,000	SEC↗
Marrazzo Jeffrey D	Chief Executive Officer	F Tax w/h	2018-01-18	2018-01-22	1,646	$50.55	$83.2K	293,354	SEC↗
Webster Stephen W	Chief Financial Officer	M Exercise	2018-01-18	2018-01-22	1,750	—	$0	4,250	SEC↗
Webster Stephen W	Chief Financial Officer	F Tax w/h	2018-01-18	2018-01-22	635	$50.55	$32.1K	3,615	SEC↗
PEREZ ROBERT J	Director	A Award deriv	2018-01-03	2018-01-04	3,000	—	$0	3,000	SEC↗
PEREZ ROBERT J	Director	A Award deriv	2018-01-03	2018-01-04	8,000	—	$0	8,000	SEC↗
Marrazzo Jeffrey D	Chief Executive Officer	M Exercise deriv	2017-12-19	2017-12-20	60,000	—	$0	182,071	SEC↗
Marrazzo Jeffrey D	Chief Executive Officer	M Exercise	2017-12-19	2017-12-20	60,000	$3.45	$207.0K	290,000	SEC↗
Furey John	Chief Operating Officer	S Sale	2017-12-11	2018-01-22	18	$46.33	$834	0	SEC↗
Furey John	Chief Operating Officer	P Buy	2017-12-08	2018-01-22	18	$73.48	$1.3K	18	SEC↗
SIGAL ELLIOT	Director	S Sale	2017-11-28	2018-04-16	29	$72.43	$2.1K	11,214	SEC↗
High Katherine A	See Remarks	M Exercise deriv	2017-11-28	2017-11-29	5,000	—	$0	73,249	SEC↗
High Katherine A	See Remarks	S Sale	2017-11-28	2017-11-29	1,500	$72.27	$108.4K	210,000	SEC↗
High Katherine A	See Remarks	M Exercise	2017-11-28	2017-11-29	5,000	$3.45	$17.3K	215,000	SEC↗
High Katherine A	See Remarks	S Sale	2017-11-28	2017-11-29	3,500	$70.91	$248.2K	211,500	SEC↗
Webster Stephen W	Chief Financial Officer	M Exercise deriv	2017-11-16	2017-11-20	10,000	—	$0	106,015	SEC↗
Webster Stephen W	Chief Financial Officer	S Sale	2017-11-16	2017-11-20	10,000	$70.14	$701.4K	2,500	SEC↗
Webster Stephen W	Chief Financial Officer	M Exercise	2017-11-16	2017-11-20	10,000	$3.45	$34.5K	12,500	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise deriv	2017-11-13	2017-11-13	2,191	—	$0	629	SEC↗
Marrazzo Jeffrey D	Chief Executive Officer	M Exercise deriv	2017-11-13	2017-11-13	20,000	—	$0	242,071	SEC↗
La Barge Joseph	Chief Legal Officer	S Sale	2017-11-13	2017-11-13	2,191	$71.65	$157.0K	5,325	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise	2017-11-13	2017-11-13	2,191	$3.45	$7.6K	10,825	SEC↗
Marrazzo Jeffrey D	Chief Executive Officer	S Sale	2017-11-13	2017-11-13	20,000	$71.54	$1.43M	230,000	SEC↗
Marrazzo Jeffrey D	Chief Executive Officer	M Exercise	2017-11-13	2017-11-13	20,000	$3.45	$69.0K	250,000	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise deriv	2017-11-09	2017-11-13	2,821	—	$0	2,820	SEC↗
La Barge Joseph	Chief Legal Officer	M Exercise deriv	2017-11-09	2017-11-13	488	—	$0	8,683	SEC↗