Open-mkt buys · 90d
—
0 trades · 0 insiders
Open-mkt sales · 90d
—
0 trades · 0 insiders
Net · 90d
$0
Insiders on file
28
Daily buy vs sell · 90 days
No data yet.
Insiders
| Insider | Role | Trades | Bought | Sold | Last trade |
|---|---|---|---|---|---|
| Weber David Allen | President & CEO | 44 | $0 | $919.5K | 2022-12-30 |
| Cayer Paul E | President and CFBO | 35 | $0 | $348.0K | 2022-12-28 |
| CAPPS VICKIE L | Director | 13 | $121.8K | $4.2K | 2022-11-28 |
| McGill Iain | Director | 7 | $0 | $0 | 2022-06-21 |
| Kennedy Ciara | Director | 4 | $0 | $0 | 2022-06-21 |
| Schroeder Theodore R | Director | 8 | $0 | $0 | 2022-06-21 |
| Lichter Jay | Director, 10% Owner | 68 | $1.75M | $7.42M | 2022-06-21 |
| Broadfoot Jill Marie | Director | 2 | $0 | $0 | 2022-06-21 |
| BREITMEYER JAMES B | Director | 5 | $0 | $0 | 2022-06-21 |
| Foster Alan Charles | Chief Scientific Officer | 4 | $0 | $10.5K | 2022-03-28 |
| Savel Robert Michael II | Chief Technical Officer | 37 | $0 | $856.8K | 2022-03-28 |
| Preston Heather | Director | 5 | $0 | $0 | 2019-06-11 |
| Bishop Katherine Mary | Chief Scientific Officer | 5 | $0 | $0 | 2019-01-15 |
| LOUMEAU ERIC J | GC & Chief Compliance Officer | 16 | $0 | $65.5K | 2018-02-01 |
| MORROW GEORGE J | Director | 3 | $0 | $0 | 2017-06-20 |
| Hakanson Dean | Chief Medical Officer | 3 | $0 | $0 | 2017-03-06 |
| LeBel Carl | Chief Scientific Officer | 32 | $0 | $1.69M | 2016-11-21 |
| Khuong Chau Quang | Director, 10% Owner | 16 | $2.75M | $11.64M | 2016-06-21 |
| Yost Anthony J | Chief Commercial Officer | 2 | $0 | $0 | 2016-03-01 |
| ORBIMED ADVISORS LLC | Director | 4 | $0 | $1.94M | 2015-11-30 |
| OrbiMed Capital GP IV LLC | Director | 10 | $2.75M | $9.70M | 2015-11-24 |
| DOVEY BRIAN H | Director | 2 | $0 | $0 | 2015-05-28 |
| Novo A/S | 10% Owner | 10 | $2.99M | $0 | 2014-08-19 |
| BONDERMAN DAVID | 10% Owner | 7 | $0 | $0 | 2014-08-18 |
| Avalon Ventures X, L.P. | 10% Owner | 34 | $1.75M | $800.0K | 2014-08-18 |
| MCKEARN JOHN P | Director | 24 | $0 | $219.8K | 2014-08-18 |
| SCHOEMAKER KATHLEEN K | 10% Owner | 7 | $0 | $0 | 2014-08-18 |
| BLAIR JAMES C | 10% Owner | 7 | $0 | $0 | 2014-08-18 |
Trade history
| Insider | Role | Code | Trade | Filed | Shares | Price | Value | Owned after | |
|---|---|---|---|---|---|---|---|---|---|
| Weber David Allen | Director | F Tax w/h | 2022-12-30 | 2022-12-30 | 91,636 | $0.09 | $8.2K | 285,863 | SEC↗ |
| Cayer Paul E | President and CFBO | F Tax w/h | 2022-12-28 | 2022-12-30 | 40,054 | $0.09 | $3.6K | 183,733 | SEC↗ |
| CAPPS VICKIE L | Director | S Sale | 2022-11-28 | 2022-11-29 | 42,242 | $0.10 | $4.2K | 3,400 | SEC↗ |
| BREITMEYER JAMES B | Director | A Award deriv | 2022-06-21 | 2022-06-23 | 27,500 | — | $0 | 27,500 | SEC↗ |
| Broadfoot Jill Marie | Director | A Award deriv | 2022-06-21 | 2022-06-23 | 27,500 | — | $0 | 27,500 | SEC↗ |
| CAPPS VICKIE L | Director | A Award deriv | 2022-06-21 | 2022-06-23 | 27,500 | — | $0 | 27,500 | SEC↗ |
| Kennedy Ciara | Director | A Award deriv | 2022-06-21 | 2022-06-23 | 27,500 | — | $0 | 27,500 | SEC↗ |
| Lichter Jay | Director | A Award deriv | 2022-06-21 | 2022-06-23 | 27,500 | — | $0 | 27,500 | SEC↗ |
| McGill Iain | Director | A Award deriv | 2022-06-21 | 2022-06-23 | 27,500 | — | $0 | 27,500 | SEC↗ |
| Schroeder Theodore R | Director | A Award deriv | 2022-06-21 | 2022-06-23 | 27,500 | — | $0 | 27,500 | SEC↗ |
| Cayer Paul E | Ch. Financial & Business Off | S Sale | 2022-03-28 | 2022-03-29 | 5,624 | $2.41 | $13.6K | 223,787 | SEC↗ |
| Foster Alan Charles | Chief Scientific Officer | S Sale | 2022-03-28 | 2022-03-29 | 2,559 | $2.41 | $6.2K | 177,017 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | S Sale | 2022-03-28 | 2022-03-29 | 3,325 | $2.41 | $8.0K | 145,735 | SEC↗ |
| Weber David Allen | President & CEO | S Sale | 2022-03-28 | 2022-03-29 | 11,243 | $2.41 | $27.1K | 377,499 | SEC↗ |
| Cayer Paul E | Ch. Financial & Business Off | S Sale | 2022-03-25 | 2022-03-29 | 4,015 | $2.39 | $9.6K | 229,411 | SEC↗ |
| Foster Alan Charles | Chief Scientific Officer | S Sale | 2022-03-25 | 2022-03-29 | 1,827 | $2.39 | $4.4K | 179,576 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | S Sale | 2022-03-25 | 2022-03-29 | 2,374 | $2.39 | $5.7K | 149,060 | SEC↗ |
| Weber David Allen | President & CEO | S Sale | 2022-03-25 | 2022-03-29 | 8,026 | $2.39 | $19.2K | 388,742 | SEC↗ |
| Weber David Allen | President & CEO | A Award deriv | 2022-01-14 | 2022-01-19 | 500,000 | — | $0 | 500,000 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | A Award deriv | 2022-01-14 | 2022-01-19 | 130,000 | — | $0 | 130,000 | SEC↗ |
| Foster Alan Charles | Chief Scientific Officer | A Award deriv | 2022-01-14 | 2022-01-19 | 130,000 | — | $0 | 130,000 | SEC↗ |
| Cayer Paul E | Ch. Financial & Business Off | A Award deriv | 2022-01-14 | 2022-01-19 | 250,000 | — | $0 | 250,000 | SEC↗ |
| Weber David Allen | President & CEO | A Award | 2022-01-14 | 2022-01-19 | 150,000 | — | $0 | 396,768 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | A Award | 2022-01-14 | 2022-01-19 | 70,000 | — | $0 | 151,434 | SEC↗ |
| Foster Alan Charles | Chief Scientific Officer | A Award | 2022-01-14 | 2022-01-19 | 70,000 | — | $0 | 181,403 | SEC↗ |
| Cayer Paul E | Ch. Financial & Business Off | A Award | 2022-01-14 | 2022-01-19 | 100,000 | — | $0 | 233,426 | SEC↗ |
| Broadfoot Jill Marie | Director | A Award deriv | 2021-08-18 | 2021-08-20 | 35,000 | — | $0 | 35,000 | SEC↗ |
| BREITMEYER JAMES B | Director | A Award deriv | 2021-06-22 | 2021-06-24 | 17,500 | — | $0 | 17,500 | SEC↗ |
| CAPPS VICKIE L | Director | A Award deriv | 2021-06-22 | 2021-06-24 | 17,500 | — | $0 | 17,500 | SEC↗ |
| Kennedy Ciara | Director | A Award deriv | 2021-06-22 | 2021-06-24 | 17,500 | — | $0 | 17,500 | SEC↗ |
| Lichter Jay | Director | A Award deriv | 2021-06-22 | 2021-06-24 | 17,500 | — | $0 | 17,500 | SEC↗ |
| McGill Iain | Director | A Award deriv | 2021-06-22 | 2021-06-24 | 17,500 | — | $0 | 17,500 | SEC↗ |
| Schroeder Theodore R | Director | A Award deriv | 2021-06-22 | 2021-06-24 | 17,500 | — | $0 | 17,500 | SEC↗ |
| Weber David Allen | President & CEO | A Award | 2021-04-16 | 2021-04-20 | 220,000 | — | $0 | 246,768 | SEC↗ |
| Cayer Paul E | Ch. Financial & Business Off | A Award | 2021-04-16 | 2021-04-20 | 110,000 | — | $0 | 133,426 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | A Award | 2021-04-16 | 2021-04-20 | 65,000 | — | $0 | 81,434 | SEC↗ |
| Lichter Jay | Director | S Sale | 2021-03-03 | 2021-03-03 | 113,935 | $2.70 | $307.6K | 0 | SEC↗ |
| Lichter Jay | Director | S Sale | 2021-03-03 | 2021-03-03 | 207,245 | $2.70 | $559.6K | 0 | SEC↗ |
| Lichter Jay | Director | S Sale | 2021-03-02 | 2021-03-02 | 138,199 | $2.90 | $400.8K | 113,935 | SEC↗ |
| Lichter Jay | Director | S Sale | 2021-03-02 | 2021-03-02 | 251,375 | $2.90 | $729.0K | 207,245 | SEC↗ |
| Lichter Jay | Director | S Sale | 2021-03-01 | 2021-03-02 | 61,619 | $2.86 | $176.2K | 252,134 | SEC↗ |
| Lichter Jay | Director | S Sale | 2021-03-01 | 2021-03-02 | 112,081 | $2.86 | $320.6K | 458,620 | SEC↗ |
| Lichter Jay | Director | S Sale | 2021-02-26 | 2021-03-02 | 117,262 | $2.83 | $331.9K | 313,753 | SEC↗ |
| Lichter Jay | Director | S Sale | 2021-02-26 | 2021-03-02 | 213,292 | $2.83 | $603.6K | 570,701 | SEC↗ |
| Lichter Jay | Director | S Sale | 2021-02-25 | 2021-02-25 | 200,739 | $2.95 | $592.2K | 783,993 | SEC↗ |
| Lichter Jay | Director | S Sale | 2021-02-25 | 2021-02-25 | 110,361 | $2.95 | $325.6K | 431,015 | SEC↗ |
| Lichter Jay | Director | S Sale | 2021-02-24 | 2021-02-25 | 178,484 | $2.98 | $531.9K | 541,376 | SEC↗ |
| Lichter Jay | Director | S Sale | 2021-02-24 | 2021-02-25 | 324,651 | $2.98 | $967.5K | 984,732 | SEC↗ |
| Lichter Jay | Director | S Sale | 2021-02-23 | 2021-02-25 | 95,113 | $2.89 | $274.9K | 719,860 | SEC↗ |
| Lichter Jay | Director | S Sale | 2021-02-23 | 2021-02-25 | 173,005 | $2.89 | $500.0K | 1,309,383 | SEC↗ |
| Weber David Allen | President & CEO | A Award deriv | 2021-01-15 | 2021-01-20 | 500,000 | — | $0 | 500,000 | SEC↗ |
| Cayer Paul E | Ch. Financial & Business Off | A Award deriv | 2021-01-15 | 2021-01-20 | 250,000 | — | $0 | 250,000 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | A Award deriv | 2021-01-15 | 2021-01-20 | 150,000 | — | $0 | 150,000 | SEC↗ |
| CAPPS VICKIE L | Director | A Award deriv | 2020-06-23 | 2020-06-25 | 17,500 | — | $0 | 17,500 | SEC↗ |
| Kennedy Ciara | Director | A Award deriv | 2020-06-23 | 2020-06-25 | 17,500 | — | $0 | 17,500 | SEC↗ |
| Lichter Jay | Director | A Award deriv | 2020-06-23 | 2020-06-25 | 17,500 | — | $0 | 17,500 | SEC↗ |
| McGill Iain | Director | A Award deriv | 2020-06-23 | 2020-06-25 | 17,500 | — | $0 | 17,500 | SEC↗ |
| BREITMEYER JAMES B | Director | A Award deriv | 2020-06-23 | 2020-06-25 | 17,500 | — | $0 | 17,500 | SEC↗ |
| Schroeder Theodore R | Director | A Award deriv | 2020-06-23 | 2020-06-25 | 17,500 | — | $0 | 17,500 | SEC↗ |
| Kennedy Ciara | Director | A Award deriv | 2020-03-01 | 2020-03-02 | 35,000 | — | $0 | 35,000 | SEC↗ |
| Cayer Paul E | Ch. Financial & Business Off | A Award deriv | 2020-01-15 | 2020-01-17 | 490,000 | — | $0 | 490,000 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | A Award deriv | 2020-01-15 | 2020-01-17 | 250,000 | — | $0 | 250,000 | SEC↗ |
| Weber David Allen | President & CEO | A Award deriv | 2020-01-15 | 2020-01-17 | 700,000 | — | $0 | 700,000 | SEC↗ |
| CAPPS VICKIE L | Director | A Award deriv | 2019-06-11 | 2019-06-13 | 17,500 | — | $0 | 17,500 | SEC↗ |
| BREITMEYER JAMES B | Director | A Award deriv | 2019-06-11 | 2019-06-13 | 17,500 | — | $0 | 17,500 | SEC↗ |
| Preston Heather | Director | A Award deriv | 2019-06-11 | 2019-06-13 | 17,500 | — | $0 | 17,500 | SEC↗ |
| Lichter Jay | Director | A Award deriv | 2019-06-11 | 2019-06-13 | 17,500 | — | $0 | 17,500 | SEC↗ |
| McGill Iain | Director | A Award deriv | 2019-06-11 | 2019-06-13 | 17,500 | — | $0 | 17,500 | SEC↗ |
| Schroeder Theodore R | Director | A Award deriv | 2019-06-11 | 2019-06-13 | 17,500 | — | $0 | 17,500 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | A Award deriv | 2019-01-15 | 2019-01-17 | 200,000 | — | $0 | 200,000 | SEC↗ |
| Bishop Katherine Mary | Chief Scientific Officer | A Award deriv | 2019-01-15 | 2019-01-17 | 215,000 | — | $0 | 215,000 | SEC↗ |
| Cayer Paul E | Ch. Financial & Business Off | A Award deriv | 2019-01-15 | 2019-01-17 | 225,000 | — | $0 | 225,000 | SEC↗ |
| Weber David Allen | President & CEO | A Award deriv | 2019-01-15 | 2019-01-17 | 800,000 | — | $0 | 800,000 | SEC↗ |
| Weber David Allen | President & CEO | A Award deriv | 2018-12-21 | 2018-12-26 | 250,000 | — | $0 | 250,000 | SEC↗ |
| CAPPS VICKIE L | Director | A Award deriv | 2018-06-19 | 2018-06-20 | 17,500 | — | $0 | 17,500 | SEC↗ |
| Preston Heather | Director | A Award deriv | 2018-06-19 | 2018-06-20 | 17,500 | — | $0 | 17,500 | SEC↗ |
| McGill Iain | Director | A Award deriv | 2018-06-19 | 2018-06-20 | 17,500 | — | $0 | 17,500 | SEC↗ |
| BREITMEYER JAMES B | Director | A Award deriv | 2018-06-19 | 2018-06-20 | 35,000 | — | $0 | 35,000 | SEC↗ |
| Schroeder Theodore R | Director | A Award deriv | 2018-06-19 | 2018-06-20 | 17,500 | — | $0 | 17,500 | SEC↗ |
| Lichter Jay | Director | A Award deriv | 2018-06-19 | 2018-06-20 | 17,500 | — | $0 | 17,500 | SEC↗ |
| Bishop Katherine Mary | Chief Scientific Officer | A Award deriv | 2018-02-01 | 2018-02-05 | 155,000 | — | $0 | 155,000 | SEC↗ |
| Cayer Paul E | Ch. Financial & Business Off | A Award deriv | 2018-02-01 | 2018-02-05 | 130,000 | — | $0 | 130,000 | SEC↗ |
| LOUMEAU ERIC J | GC & Chief Compliance Office | A Award deriv | 2018-02-01 | 2018-02-05 | 110,000 | — | $0 | 110,000 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | A Award deriv | 2018-02-01 | 2018-02-05 | 165,000 | — | $0 | 165,000 | SEC↗ |
| Weber David Allen | President & CEO | A Award deriv | 2018-02-01 | 2018-02-05 | 400,000 | — | $0 | 400,000 | SEC↗ |
| Bishop Katherine Mary | Chief Scientific Officer | A Award deriv | 2018-01-19 | 2018-01-23 | 100,000 | — | $0 | 100,000 | SEC↗ |
| Bishop Katherine Mary | Chief Scientific Officer | D To issuer deriv | 2018-01-19 | 2018-01-23 | 150,000 | — | $0 | 0 | SEC↗ |
| LOUMEAU ERIC J | GC & Chief Compliance Office | D To issuer deriv | 2018-01-19 | 2018-01-23 | 50,000 | — | $0 | 0 | SEC↗ |
| LOUMEAU ERIC J | GC & Chief Compliance Office | D To issuer deriv | 2018-01-19 | 2018-01-23 | 70,000 | — | $0 | 0 | SEC↗ |
| LOUMEAU ERIC J | GC & Chief Compliance Office | A Award deriv | 2018-01-19 | 2018-01-23 | 66,666 | — | $0 | 66,666 | SEC↗ |
| LOUMEAU ERIC J | GC & Chief Compliance Office | A Award deriv | 2018-01-19 | 2018-01-23 | 46,666 | — | $0 | 46,666 | SEC↗ |
| LOUMEAU ERIC J | GC & Chief Compliance Office | A Award deriv | 2018-01-19 | 2018-01-23 | 33,333 | — | $0 | 33,333 | SEC↗ |
| LOUMEAU ERIC J | GC & Chief Compliance Office | D To issuer deriv | 2018-01-19 | 2018-01-23 | 100,000 | — | $0 | 0 | SEC↗ |
| Cayer Paul E | Ch. Financial & Business Off | D To issuer deriv | 2018-01-19 | 2018-01-23 | 60,000 | — | $0 | 0 | SEC↗ |
| Cayer Paul E | Ch. Financial & Business Off | A Award deriv | 2018-01-19 | 2018-01-23 | 46,666 | — | $0 | 46,666 | SEC↗ |
| Cayer Paul E | Ch. Financial & Business Off | A Award deriv | 2018-01-19 | 2018-01-23 | 40,000 | — | $0 | 40,000 | SEC↗ |
| Cayer Paul E | Ch. Financial & Business Off | D To issuer deriv | 2018-01-19 | 2018-01-23 | 70,000 | — | $0 | 0 | SEC↗ |
| Cayer Paul E | Ch. Financial & Business Off | D To issuer deriv | 2018-01-19 | 2018-01-23 | 70,000 | — | $0 | 0 | SEC↗ |
| Cayer Paul E | Ch. Financial & Business Off | A Award deriv | 2018-01-19 | 2018-01-23 | 46,666 | — | $0 | 46,666 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | A Award deriv | 2018-01-19 | 2018-01-23 | 36,666 | — | $0 | 36,666 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | D To issuer deriv | 2018-01-19 | 2018-01-23 | 30,000 | — | $0 | 0 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | D To issuer deriv | 2018-01-19 | 2018-01-23 | 50,000 | — | $0 | 0 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | A Award deriv | 2018-01-19 | 2018-01-23 | 20,000 | — | $0 | 20,000 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | D To issuer deriv | 2018-01-19 | 2018-01-23 | 55,000 | — | $0 | 0 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | A Award deriv | 2018-01-19 | 2018-01-23 | 33,333 | — | $0 | 33,333 | SEC↗ |
| Weber David Allen | President & CEO | A Award deriv | 2018-01-19 | 2018-01-23 | 86,666 | — | $0 | 86,666 | SEC↗ |
| Weber David Allen | President & CEO | A Award deriv | 2018-01-19 | 2018-01-23 | 153,333 | — | $0 | 153,333 | SEC↗ |
| Weber David Allen | President & CEO | A Award deriv | 2018-01-19 | 2018-01-23 | 133,333 | — | $0 | 133,333 | SEC↗ |
| Weber David Allen | President & CEO | D To issuer deriv | 2018-01-19 | 2018-01-23 | 230,000 | — | $0 | 0 | SEC↗ |
| Weber David Allen | President & CEO | D To issuer deriv | 2018-01-19 | 2018-01-23 | 200,000 | — | $0 | 0 | SEC↗ |
| Weber David Allen | President & CEO | D To issuer deriv | 2018-01-19 | 2018-01-23 | 130,000 | — | $0 | 0 | SEC↗ |
| Lichter Jay | Director | M Exercise deriv | 2017-08-31 | 2017-09-05 | 14,106 | — | $0 | 0 | SEC↗ |
| Lichter Jay | Director | M Exercise deriv | 2017-08-31 | 2017-09-05 | 14,106 | — | $0 | 0 | SEC↗ |
| Lichter Jay | Director | M Exercise deriv | 2017-08-31 | 2017-09-05 | 14,106 | — | $0 | 0 | SEC↗ |
| Lichter Jay | Director | M Exercise deriv | 2017-08-31 | 2017-09-05 | 14,106 | — | $0 | 0 | SEC↗ |
| Lichter Jay | Director | M Exercise deriv | 2017-08-31 | 2017-09-05 | 14,106 | — | $0 | 0 | SEC↗ |
| Lichter Jay | Director | M Exercise deriv | 2017-08-31 | 2017-09-05 | 14,106 | — | $0 | 0 | SEC↗ |
| Lichter Jay | Director | M Exercise deriv | 2017-08-31 | 2017-09-05 | 14,106 | — | $0 | 0 | SEC↗ |
| Lichter Jay | Director | M Exercise deriv | 2017-08-31 | 2017-09-05 | 14,106 | — | $0 | 0 | SEC↗ |
| Lichter Jay | Director | M Exercise deriv | 2017-08-31 | 2017-09-05 | 14,106 | — | $0 | 0 | SEC↗ |
| Lichter Jay | Director | M Exercise deriv | 2017-08-31 | 2017-09-05 | 14,106 | — | $0 | 0 | SEC↗ |
| Lichter Jay | Director | M Exercise | 2017-08-31 | 2017-09-05 | 141,060 | $14.18 | $2.00M | 2,406,212 | SEC↗ |
| Lichter Jay | Director | F Tax w/h | 2017-08-31 | 2017-09-05 | 108,851 | $18.37 | $2.00M | 2,297,361 | SEC↗ |
| LOUMEAU ERIC J | GC & Chief Compliance Office | S Sale | 2017-06-26 | 2017-06-27 | 1,206 | $18.75 | $22.6K | 0 | SEC↗ |
| LOUMEAU ERIC J | GC & Chief Compliance Office | S Sale | 2017-06-23 | 2017-06-27 | 2,316 | $18.50 | $42.8K | 1,206 | SEC↗ |
| CAPPS VICKIE L | Director | A Award deriv | 2017-06-20 | 2017-07-14 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Lichter Jay | Director | A Award deriv | 2017-06-20 | 2017-07-14 | 15,000 | — | $0 | 15,000 | SEC↗ |
| McGill Iain | Director | A Award deriv | 2017-06-20 | 2017-07-14 | 15,000 | — | $0 | 15,000 | SEC↗ |
| MORROW GEORGE J | Director | A Award deriv | 2017-06-20 | 2017-07-14 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Preston Heather | Director | A Award deriv | 2017-06-20 | 2017-07-14 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Schroeder Theodore R | Director | A Award deriv | 2017-06-20 | 2017-07-14 | 15,000 | — | $0 | 15,000 | SEC↗ |
| LOUMEAU ERIC J | GC & Chief Compliance Office | A Award | 2017-06-01 | 2017-06-27 | 1,206 | $11.43 | $13.8K | 3,522 | SEC↗ |
| Weber David Allen | President & CEO | A Award deriv | 2017-03-06 | 2017-03-08 | 200,000 | — | $0 | 200,000 | SEC↗ |
| Cayer Paul E | Ch. Financial & Business Off | A Award deriv | 2017-03-06 | 2017-03-08 | 70,000 | — | $0 | 70,000 | SEC↗ |
| Hakanson Dean | Chief Medical Officer | A Award deriv | 2017-03-06 | 2017-03-08 | 65,000 | — | $0 | 65,000 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | A Award deriv | 2017-03-06 | 2017-03-08 | 50,000 | — | $0 | 50,000 | SEC↗ |
| LOUMEAU ERIC J | GC & Chief Compliance Office | A Award deriv | 2017-03-06 | 2017-03-08 | 50,000 | — | $0 | 50,000 | SEC↗ |
| Bishop Katherine Mary | Chief Scientific Officer | A Award deriv | 2017-01-04 | 2017-01-06 | 150,000 | — | $0 | 150,000 | SEC↗ |
| LOUMEAU ERIC J | GC & Chief Compliance Office | A Award | 2016-12-01 | 2017-06-27 | 647 | $13.05 | $8.4K | 2,316 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | M Exercise deriv | 2016-11-21 | 2016-11-22 | 1,456 | — | $0 | 12,803 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | M Exercise | 2016-11-21 | 2016-11-22 | 1,456 | $3.17 | $4.6K | 10,914 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | S Sale | 2016-11-21 | 2016-11-22 | 1,456 | $18.07 | $26.3K | 9,458 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | M Exercise deriv | 2016-11-18 | 2016-11-22 | 5,626 | — | $0 | 14,259 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | M Exercise deriv | 2016-11-18 | 2016-11-22 | 3,543 | — | $0 | 31,891 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | S Sale | 2016-11-18 | 2016-11-22 | 9,169 | $18.07 | $165.7K | 9,458 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | M Exercise | 2016-11-18 | 2016-11-22 | 5,626 | $3.17 | $17.8K | 18,627 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | M Exercise | 2016-11-18 | 2016-11-22 | 3,543 | $6.33 | $22.4K | 13,001 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | M Exercise deriv | 2016-09-06 | 2016-09-08 | 15,946 | — | $0 | 35,434 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | M Exercise deriv | 2016-09-06 | 2016-09-08 | 5,304 | — | $0 | 19,885 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | S Sale | 2016-09-06 | 2016-09-08 | 3,813 | $17.95 | $68.4K | 14,762 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | S Sale | 2016-09-06 | 2016-09-08 | 12,133 | $17.95 | $217.8K | 18,575 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | S Sale | 2016-09-06 | 2016-09-08 | 5,304 | $17.95 | $95.2K | 9,458 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | M Exercise | 2016-09-06 | 2016-09-08 | 3,813 | $6.33 | $24.1K | 25,404 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | M Exercise | 2016-09-06 | 2016-09-08 | 12,133 | $6.33 | $76.8K | 21,591 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | M Exercise | 2016-09-06 | 2016-09-08 | 5,304 | $3.17 | $16.8K | 30,708 | SEC↗ |
| McGill Iain | Director | A Award deriv | 2016-08-02 | 2016-08-04 | 25,000 | — | $0 | 25,000 | SEC↗ |
| Schroeder Theodore R | Director | A Award deriv | 2016-06-21 | 2016-06-21 | 15,000 | — | $0 | 15,000 | SEC↗ |
| CAPPS VICKIE L | Director | A Award deriv | 2016-06-21 | 2016-06-21 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Khuong Chau Quang | Director | A Award deriv | 2016-06-21 | 2016-06-21 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Lichter Jay | Director | A Award deriv | 2016-06-21 | 2016-06-21 | 15,000 | — | $0 | 15,000 | SEC↗ |
| MORROW GEORGE J | Director | A Award deriv | 2016-06-21 | 2016-06-21 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Preston Heather | Director | A Award deriv | 2016-06-21 | 2016-06-21 | 15,000 | — | $0 | 15,000 | SEC↗ |
| LOUMEAU ERIC J | GC & Chief Compliance Office | A Award | 2016-06-01 | 2017-06-27 | 1,021 | $13.13 | $13.4K | 1,669 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | A Award | 2016-06-01 | 2016-09-08 | 275 | $13.13 | $3.6K | 9,458 | SEC↗ |
| Cayer Paul E | Ch. Financial & Business Off | A Award deriv | 2016-03-01 | 2016-03-03 | 70,000 | — | $0 | 70,000 | SEC↗ |
| Hakanson Dean | Chief Medical Officer | A Award deriv | 2016-03-01 | 2016-03-03 | 100,000 | — | $0 | 100,000 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | A Award deriv | 2016-03-01 | 2016-03-03 | 35,000 | — | $0 | 35,000 | SEC↗ |
| LOUMEAU ERIC J | GC & Chief Compliance Office | A Award deriv | 2016-03-01 | 2016-03-03 | 70,000 | — | $0 | 70,000 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | A Award deriv | 2016-03-01 | 2016-03-03 | 55,000 | — | $0 | 55,000 | SEC↗ |
| Weber David Allen | President & CEO | A Award deriv | 2016-03-01 | 2016-03-03 | 230,000 | — | $0 | 230,000 | SEC↗ |
| Yost Anthony J | Chief Commercial Officer | A Award deriv | 2016-03-01 | 2016-03-03 | 75,000 | — | $0 | 75,000 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | M Exercise deriv | 2015-12-21 | 2015-12-22 | 4,674 | — | $0 | 25,189 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | M Exercise deriv | 2015-12-21 | 2015-12-22 | 16,576 | — | $0 | 51,380 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | M Exercise | 2015-12-21 | 2015-12-22 | 16,576 | $6.33 | $104.9K | 25,496 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | S Sale | 2015-12-21 | 2015-12-22 | 13,189 | $27.83 | $367.0K | 16,981 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | S Sale | 2015-12-21 | 2015-12-22 | 8,061 | $28.38 | $228.8K | 8,920 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | M Exercise | 2015-12-21 | 2015-12-22 | 4,674 | $3.17 | $14.8K | 30,170 | SEC↗ |
| Cayer Paul E | Ch. Financial & Business Off | M Exercise deriv | 2015-12-17 | 2015-12-18 | 3,000 | — | $0 | 77,492 | SEC↗ |
| Cayer Paul E | Ch. Financial & Business Off | M Exercise | 2015-12-17 | 2015-12-18 | 3,000 | $6.33 | $19.0K | 12,610 | SEC↗ |
| Cayer Paul E | Ch. Financial & Business Off | S Sale | 2015-12-17 | 2015-12-18 | 300 | $30.19 | $9.1K | 9,610 | SEC↗ |
| Cayer Paul E | Ch. Financial & Business Off | S Sale | 2015-12-17 | 2015-12-18 | 2,700 | $29.65 | $80.1K | 9,910 | SEC↗ |
| Weber David Allen | President & CEO | M Exercise deriv | 2015-12-15 | 2015-12-16 | 5,208 | — | $0 | 390,149 | SEC↗ |
| Weber David Allen | President & CEO | M Exercise | 2015-12-15 | 2015-12-16 | 5,208 | $1.76 | $9.2K | 22,811 | SEC↗ |
| Weber David Allen | President & CEO | S Sale | 2015-12-15 | 2015-12-16 | 5,208 | $27.25 | $141.9K | 17,603 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | M Exercise deriv | 2015-12-14 | 2015-12-16 | 3,412 | — | $0 | 32,994 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | M Exercise deriv | 2015-12-14 | 2015-12-16 | 1,588 | — | $0 | 79,047 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | S Sale | 2015-12-14 | 2015-12-16 | 100 | $27.70 | $2.8K | 1,256 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | M Exercise | 2015-12-14 | 2015-12-16 | 1,588 | $1.76 | $2.8K | 6,256 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | M Exercise | 2015-12-14 | 2015-12-16 | 3,412 | $6.33 | $21.6K | 4,668 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | S Sale | 2015-12-14 | 2015-12-16 | 2,322 | $25.14 | $58.4K | 3,934 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | S Sale | 2015-12-14 | 2015-12-16 | 1,289 | $27.26 | $35.1K | 1,356 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | S Sale | 2015-12-14 | 2015-12-16 | 1,289 | $26.15 | $33.7K | 2,645 | SEC↗ |
| LOUMEAU ERIC J | GC & Chief Compliance Office | A Award | 2015-12-01 | 2017-06-27 | 648 | $20.37 | $13.2K | 648 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | A Award | 2015-12-01 | 2016-09-08 | 263 | $13.60 | $3.6K | 9,183 | SEC↗ |
| Khuong Chau Quang | Director | S Sale | 2015-11-30 | 2015-11-30 | 590 | $29.22 | $17.2K | 1,850,094 | SEC↗ |
| Khuong Chau Quang | Director | S Sale | 2015-11-30 | 2015-11-30 | 2,716 | $28.64 | $77.8K | 1,850,684 | SEC↗ |
| ORBIMED ADVISORS LLC | Director | S Sale | 2015-11-30 | 2015-11-30 | 590 | $29.22 | $17.2K | 1,850,094 | SEC↗ |
| ORBIMED ADVISORS LLC | Director | S Sale | 2015-11-30 | 2015-11-30 | 2,716 | $28.64 | $77.8K | 1,850,684 | SEC↗ |
| Khuong Chau Quang | Director | S Sale | 2015-11-27 | 2015-11-30 | 29,000 | $28.97 | $840.1K | 1,853,400 | SEC↗ |
| ORBIMED ADVISORS LLC | Director | S Sale | 2015-11-27 | 2015-11-30 | 29,000 | $28.97 | $840.1K | 1,853,400 | SEC↗ |
| Khuong Chau Quang | Director | S Sale | 2015-11-25 | 2015-11-30 | 34,800 | $28.91 | $1.01M | 1,882,400 | SEC↗ |
| ORBIMED ADVISORS LLC | Director | S Sale | 2015-11-25 | 2015-11-30 | 34,800 | $28.91 | $1.01M | 1,882,400 | SEC↗ |
| OrbiMed Capital GP IV LLC | Director | S Sale | 2015-11-24 | 2015-11-24 | 36,100 | $28.75 | $1.04M | 1,917,200 | SEC↗ |
| Khuong Chau Quang | Director | S Sale | 2015-11-24 | 2015-11-24 | 36,100 | $28.75 | $1.04M | 1,917,200 | SEC↗ |
| OrbiMed Capital GP IV LLC | Director | S Sale | 2015-11-23 | 2015-11-24 | 80,800 | $28.45 | $2.30M | 1,953,300 | SEC↗ |
| Khuong Chau Quang | Director | S Sale | 2015-11-23 | 2015-11-24 | 80,800 | $28.45 | $2.30M | 1,953,300 | SEC↗ |
| OrbiMed Capital GP IV LLC | Director | S Sale | 2015-11-20 | 2015-11-24 | 83,900 | $28.59 | $2.40M | 2,034,100 | SEC↗ |
| Khuong Chau Quang | Director | S Sale | 2015-11-20 | 2015-11-24 | 83,900 | $28.59 | $2.40M | 2,034,100 | SEC↗ |
| Khuong Chau Quang | Director | S Sale | 2015-11-19 | 2015-11-19 | 127,300 | $28.60 | $3.64M | 2,118,000 | SEC↗ |
| OrbiMed Capital GP IV LLC | Director | S Sale | 2015-11-19 | 2015-11-19 | 127,300 | $28.60 | $3.64M | 2,118,000 | SEC↗ |
| Cayer Paul E | Ch. Financial & Business Off | M Exercise deriv | 2015-11-17 | 2015-11-17 | 3,000 | — | $0 | 80,492 | SEC↗ |
| Cayer Paul E | Ch. Financial & Business Off | S Sale | 2015-11-17 | 2015-11-17 | 3,000 | $28.69 | $86.1K | 9,610 | SEC↗ |
| Cayer Paul E | Ch. Financial & Business Off | M Exercise | 2015-11-17 | 2015-11-17 | 3,000 | $6.33 | $19.0K | 12,610 | SEC↗ |
| Khuong Chau Quang | Director | S Sale | 2015-11-17 | 2015-11-19 | 200 | $29.09 | $5.8K | 2,245,300 | SEC↗ |
| Khuong Chau Quang | Director | S Sale | 2015-11-17 | 2015-11-19 | 10,898 | $28.80 | $313.9K | 2,245,500 | SEC↗ |
| OrbiMed Capital GP IV LLC | Director | S Sale | 2015-11-17 | 2015-11-19 | 10,898 | $28.80 | $313.9K | 2,245,500 | SEC↗ |
| OrbiMed Capital GP IV LLC | Director | S Sale | 2015-11-17 | 2015-11-19 | 200 | $29.09 | $5.8K | 2,245,300 | SEC↗ |
| Weber David Allen | President & CEO | M Exercise deriv | 2015-11-16 | 2015-11-17 | 5,208 | — | $0 | 395,357 | SEC↗ |
| Weber David Allen | President & CEO | M Exercise | 2015-11-16 | 2015-11-17 | 5,208 | $1.76 | $9.2K | 22,811 | SEC↗ |
| Weber David Allen | President & CEO | S Sale | 2015-11-16 | 2015-11-17 | 100 | $29.25 | $2.9K | 17,603 | SEC↗ |
| Weber David Allen | President & CEO | S Sale | 2015-11-16 | 2015-11-17 | 5,108 | $28.56 | $145.9K | 17,703 | SEC↗ |
| Weber David Allen | President & CEO | M Exercise deriv | 2015-11-13 | 2015-11-13 | 10,416 | — | $0 | 400,565 | SEC↗ |
| Weber David Allen | President & CEO | S Sale | 2015-11-13 | 2015-11-13 | 10,416 | $30.95 | $322.4K | 539 | SEC↗ |
| Weber David Allen | President & CEO | M Exercise | 2015-11-13 | 2015-11-13 | 10,416 | $1.76 | $18.3K | 10,955 | SEC↗ |
| Weber David Allen | President & CEO | M Exercise deriv | 2015-11-11 | 2015-11-12 | 5,208 | — | $0 | 410,981 | SEC↗ |
| Cayer Paul E | CFO/Ch. Business Offcr & Sec | M Exercise deriv | 2015-11-11 | 2015-11-12 | 1,547 | — | $0 | 83,492 | SEC↗ |
| Cayer Paul E | CFO/Ch. Business Offcr & Sec | M Exercise deriv | 2015-11-11 | 2015-11-12 | 1,453 | — | $0 | 137,088 | SEC↗ |
| Weber David Allen | President & CEO | M Exercise | 2015-11-11 | 2015-11-12 | 5,208 | $1.76 | $9.2K | 5,747 | SEC↗ |
| Weber David Allen | President & CEO | S Sale | 2015-11-11 | 2015-11-12 | 5,208 | $24.95 | $129.9K | 539 | SEC↗ |
| Cayer Paul E | CFO/Ch. Business Offcr & Sec | M Exercise | 2015-11-11 | 2015-11-12 | 1,453 | $1.76 | $2.6K | 11,063 | SEC↗ |
| Cayer Paul E | CFO/Ch. Business Offcr & Sec | S Sale | 2015-11-11 | 2015-11-12 | 3,000 | $24.95 | $74.8K | 9,610 | SEC↗ |
| Cayer Paul E | CFO/Ch. Business Offcr & Sec | M Exercise | 2015-11-11 | 2015-11-12 | 1,547 | $6.33 | $9.8K | 12,610 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | M Exercise deriv | 2015-09-21 | 2015-09-22 | 4,167 | $24.36 | $101.5K | 137,284 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | M Exercise deriv | 2015-09-21 | 2015-09-22 | 17,083 | $24.36 | $416.1K | 67,956 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | M Exercise | 2015-09-21 | 2015-09-22 | 17,083 | $6.33 | $108.1K | 30,170 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | M Exercise | 2015-09-21 | 2015-09-22 | 4,167 | $1.76 | $7.3K | 13,087 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | S Sale | 2015-09-21 | 2015-09-22 | 21,250 | $24.36 | $517.6K | 8,920 | SEC↗ |
| Cayer Paul E | CFO/Ch. Business Offcr & Sec | M Exercise deriv | 2015-09-17 | 2015-09-18 | 3,000 | $24.95 | $74.8K | 138,541 | SEC↗ |
| Cayer Paul E | CFO/Ch. Business Offcr & Sec | S Sale | 2015-09-17 | 2015-09-18 | 3,000 | $24.95 | $74.8K | 9,610 | SEC↗ |
| Cayer Paul E | CFO/Ch. Business Offcr & Sec | M Exercise | 2015-09-17 | 2015-09-18 | 3,000 | $1.76 | $5.3K | 12,610 | SEC↗ |
| Weber David Allen | President & CEO | M Exercise deriv | 2015-09-15 | 2015-09-16 | 5,216 | $24.95 | $130.1K | 416,189 | SEC↗ |
| Weber David Allen | President & CEO | M Exercise | 2015-09-15 | 2015-09-16 | 5,216 | $1.76 | $9.2K | 5,755 | SEC↗ |
| Weber David Allen | President & CEO | S Sale | 2015-09-15 | 2015-09-16 | 5,216 | $24.95 | $130.1K | 539 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | M Exercise deriv | 2015-09-14 | 2015-09-15 | 1,587 | $1.76 | $2.8K | 80,635 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | M Exercise deriv | 2015-09-14 | 2015-09-15 | 3,413 | $6.33 | $21.6K | 36,406 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | M Exercise | 2015-09-14 | 2015-09-15 | 3,413 | $6.33 | $21.6K | 6,256 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | M Exercise | 2015-09-14 | 2015-09-15 | 1,587 | $1.76 | $2.8K | 2,843 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | S Sale | 2015-09-14 | 2015-09-15 | 5,000 | $23.98 | $119.9K | 1,256 | SEC↗ |
| Schroeder Theodore R | Director | A Award deriv | 2015-08-28 | 2015-09-01 | 25,000 | — | $0 | 25,000 | SEC↗ |
| Preston Heather | Director | A Award deriv | 2015-06-19 | 2015-06-22 | 15,000 | — | $0 | 15,000 | SEC↗ |
| CAPPS VICKIE L | Director | A Award deriv | 2015-06-19 | 2015-06-22 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Khuong Chau Quang | Director | A Award deriv | 2015-06-19 | 2015-06-22 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Lichter Jay | Director | A Award deriv | 2015-06-19 | 2015-06-22 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | M Exercise deriv | 2015-06-15 | 2015-06-17 | 14,788 | $6.33 | $93.6K | 39,819 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | M Exercise deriv | 2015-06-15 | 2015-06-17 | 10,212 | $1.76 | $18.0K | 82,222 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | M Exercise | 2015-06-15 | 2015-06-17 | 14,788 | $6.33 | $93.6K | 26,256 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | S Sale | 2015-06-15 | 2015-06-17 | 25,000 | $23.73 | $593.3K | 1,256 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | M Exercise | 2015-06-15 | 2015-06-17 | 10,212 | $1.76 | $18.0K | 11,468 | SEC↗ |
| Cayer Paul E | CFO/Ch. Business Offcr & Sec | A Award | 2015-06-01 | 2015-06-02 | 2,500 | $13.60 | $34.0K | 2,500 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | A Award | 2015-06-01 | 2015-06-02 | 389 | $13.60 | $5.3K | 389 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | A Award | 2015-06-01 | 2015-06-02 | 1,256 | $13.60 | $17.1K | 1,256 | SEC↗ |
| Weber David Allen | President & CEO | A Award | 2015-06-01 | 2015-06-02 | 539 | $13.60 | $7.3K | 539 | SEC↗ |
| DOVEY BRIAN H | Director | J Other | 2015-05-28 | 2015-05-29 | 32,745 | — | $0 | 32,745 | SEC↗ |
| DOVEY BRIAN H | Director | J Other | 2015-05-28 | 2015-05-29 | 250,000 | — | $0 | 1,329,323 | SEC↗ |
| CAPPS VICKIE L | Director | P Buy | 2015-05-22 | 2015-05-27 | 3,400 | $24.36 | $82.8K | 3,400 | SEC↗ |
| CAPPS VICKIE L | Director | P Buy | 2015-05-22 | 2015-05-27 | 1,600 | $24.35 | $39.0K | 1,600 | SEC↗ |
| LOUMEAU ERIC J | GC & Chief Compliance Office | A Award deriv | 2015-05-15 | 2015-05-18 | 100,000 | $31.59 | $3.16M | 100,000 | SEC↗ |
| MORROW GEORGE J | Director | A Award deriv | 2015-04-28 | 2015-04-30 | 25,000 | $27.58 | $689.5K | 25,000 | SEC↗ |
| Hakanson Dean | Chief Medical Officer | A Award deriv | 2015-04-01 | 2015-04-03 | 115,000 | $34.60 | $3.98M | 115,000 | SEC↗ |
| Cayer Paul E | CFO/Ch. Business Offcr & Sec | A Award deriv | 2014-12-11 | 2014-12-12 | 60,000 | — | $0 | 60,000 | SEC↗ |
| LeBel Carl | Chief Scientific Officer | A Award deriv | 2014-12-11 | 2014-12-12 | 40,000 | — | $0 | 40,000 | SEC↗ |
| Savel Robert Michael II | Chief Technical Officer | A Award deriv | 2014-12-11 | 2014-12-12 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Weber David Allen | President & CEO | A Award deriv | 2014-12-11 | 2014-12-12 | 130,000 | — | $0 | 130,000 | SEC↗ |
| Yost Anthony J | Chief Commercial Officer | A Award deriv | 2014-10-20 | 2014-10-21 | 180,000 | $22.74 | $4.09M | 180,000 | SEC↗ |
| Novo A/S | 10% Owner | P Buy | 2014-08-19 | 2014-08-21 | 15,690 | $15.50 | $243.2K | 2,175,025 | SEC↗ |
| SCHOEMAKER KATHLEEN K | 10% Owner | F Tax w/h deriv | 2014-08-18 | 2014-08-18 | 186,828 | — | $0 | 0 | SEC↗ |
| SCHOEMAKER KATHLEEN K | 10% Owner | M Exercise deriv | 2014-08-18 | 2014-08-18 | 67,755 | — | $0 | 0 | SEC↗ |
| SCHOEMAKER KATHLEEN K | 10% Owner | C Conversion deriv | 2014-08-18 | 2014-08-18 | 925,479 | — | $0 | 0 | SEC↗ |
| SCHOEMAKER KATHLEEN K | 10% Owner | C Conversion deriv | 2014-08-18 | 2014-08-18 | 436,485 | — | $0 | 0 | SEC↗ |
| BLAIR JAMES C | 10% Owner | C Conversion deriv | 2014-08-18 | 2014-08-18 | 3,238 | — | $0 | 0 | SEC↗ |
| BLAIR JAMES C | 10% Owner | C Conversion deriv | 2014-08-18 | 2014-08-18 | 6,866 | — | $0 | 0 | SEC↗ |
| BLAIR JAMES C | 10% Owner | M Exercise deriv | 2014-08-18 | 2014-08-18 | 502 | — | $0 | 0 | SEC↗ |
| BLAIR JAMES C | 10% Owner | F Tax w/h deriv | 2014-08-18 | 2014-08-18 | 1,386 | — | $0 | 0 | SEC↗ |
| BONDERMAN DAVID | 10% Owner | C Conversion deriv | 2014-08-18 | 2014-08-19 | 1,199,695 | — | $0 | 0 | SEC↗ |
| BONDERMAN DAVID | 10% Owner | C Conversion deriv | 2014-08-18 | 2014-08-19 | 439,724 | — | $0 | 0 | SEC↗ |
| BONDERMAN DAVID | 10% Owner | C Conversion deriv | 2014-08-18 | 2014-08-19 | 68,259 | — | $0 | 1,199,695 | SEC↗ |
| BONDERMAN DAVID | 10% Owner | C Conversion deriv | 2014-08-18 | 2014-08-19 | 348,041 | — | $0 | 0 | SEC↗ |
| BONDERMAN DAVID | 10% Owner | C Conversion deriv | 2014-08-18 | 2014-08-19 | 68,259 | — | $0 | 0 | SEC↗ |
| Novo A/S | 10% Owner | C Conversion deriv | 2014-08-18 | 2014-08-19 | 348,041 | — | $0 | 0 | SEC↗ |
| Novo A/S | 10% Owner | X Exercise deriv | 2014-08-18 | 2014-08-19 | 36,405 | — | $0 | 0 | SEC↗ |
| Novo A/S | 10% Owner | X Exercise deriv | 2014-08-18 | 2014-08-19 | 31,854 | — | $0 | 0 | SEC↗ |
| Novo A/S | 10% Owner | C Conversion deriv | 2014-08-18 | 2014-08-19 | 439,724 | — | $0 | 0 | SEC↗ |
| Novo A/S | 10% Owner | C Conversion deriv | 2014-08-18 | 2014-08-19 | 1,131,436 | — | $0 | 0 | SEC↗ |
| Lichter Jay | Director, 10% Owner | C Conversion deriv | 2014-08-18 | 2014-08-19 | 91,011 | — | $0 | 91,011 | SEC↗ |
| Lichter Jay | Director, 10% Owner | C Conversion deriv | 2014-08-18 | 2014-08-19 | 91,011 | — | $0 | 0 | SEC↗ |
| Lichter Jay | Director, 10% Owner | C Conversion deriv | 2014-08-18 | 2014-08-19 | 14,106 | — | $0 | 14,106 | SEC↗ |
| Lichter Jay | Director, 10% Owner | C Conversion deriv | 2014-08-18 | 2014-08-19 | 6,432 | — | $0 | 0 | SEC↗ |
| Lichter Jay | Director, 10% Owner | C Conversion deriv | 2014-08-18 | 2014-08-19 | 14,106 | — | $0 | 14,106 | SEC↗ |
| Lichter Jay | Director, 10% Owner | C Conversion deriv | 2014-08-18 | 2014-08-19 | 6,432 | — | $0 | 0 | SEC↗ |
| Lichter Jay | Director, 10% Owner | C Conversion deriv | 2014-08-18 | 2014-08-19 | 14,106 | — | $0 | 14,106 | SEC↗ |