Open-mkt buys · 90d
—
0 trades · 0 insiders
Open-mkt sales · 90d
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0 trades · 0 insiders
Net · 90d
$0
Insiders on file
32
Daily buy vs sell · 90 days
No data yet.
Insiders
| Insider | Role | Trades | Bought | Sold | Last trade |
|---|---|---|---|---|---|
| Ricardo Alonso | See Remarks | 15 | $0 | $554.5K | 2020-04-02 |
| King John C | Chief Commercial Officer | 10 | $0 | $0 | 2020-04-02 |
| Brennan Aoife | Director | 4 | $0 | $0 | 2020-04-02 |
| Heft Robert | Director | 7 | $0 | $0 | 2020-04-02 |
| Read Simon | Chief Scientific Officer | 37 | $0 | $2.49M | 2020-04-02 |
| Farzaneh-Far Ramin | Chief Medical Officer | 66 | $0 | $4.11M | 2020-04-02 |
| Treco Douglas A | President and CEO | 15 | $0 | $0 | 2020-04-02 |
| Cumbo Alexander | Director | 4 | $0 | $0 | 2020-04-02 |
| Shah Rajeev M. | Director, 10% Owner | 14 | $32.70M | $0 | 2020-04-02 |
| Lubner David Charles | Executive VP and CFO | 16 | $0 | $0 | 2020-04-02 |
| PEARSON TIMOTHY R | Director | 7 | $0 | $0 | 2020-04-02 |
| NEA 13 GP, Ltd | 10% Owner | 12 | $16.40M | $5.7K | 2020-04-02 |
| Mathers Edward T | Director | 6 | $0 | $0 | 2020-04-02 |
| RA Capital Healthcare Fund LP | Director, 10% Owner | 7 | $2.10M | $0 | 2020-04-02 |
| NEA Partners 13, Limited Partnership | 10% Owner | 1 | $10.00M | $0 | 2018-12-14 |
| RA CAPITAL MANAGEMENT, LLC | Director, 10% Owner | 1 | $15.60M | $0 | 2018-12-12 |
| Bisgaard Peter | Director | 2 | $0 | $0 | 2018-06-28 |
| Kolchinsky Peter | Director, 10% Owner | 4 | $15.00M | $0 | 2018-06-28 |
| Lettmann Jason | Director, 10% Owner | 21 | $5.12M | $4.4K | 2017-06-20 |
| NOVARTIS AG | 10% Owner | 28 | $1.10M | $6.05M | 2017-06-19 |
| Novartis Bioventures Ltd | 10% Owner | 3 | $0 | $689.4K | 2017-06-05 |
| Viswanathan Ravi | 10% Owner | 10 | $4.40M | $5.7K | 2016-10-31 |
| MORGENTHALER VENTURE PARTNERS IX LP | 10% Owner | 10 | $3.43M | $4.4K | 2016-10-31 |
| Novo A/S | 10% Owner | 5 | $3.20M | $0 | 2016-10-31 |
| Weller Harry R | 10% Owner | 10 | $4.40M | $5.7K | 2016-10-31 |
| BASKETT FOREST | 10% Owner | 10 | $4.40M | $5.7K | 2016-10-31 |
| KOLLURI KRISHNA KITTU | 10% Owner | 10 | $4.40M | $5.7K | 2016-10-31 |
| SANDELL SCOTT D | 10% Owner | 10 | $4.40M | $5.7K | 2016-10-31 |
| KERINS PATRICK J | 10% Owner | 10 | $4.40M | $5.7K | 2016-10-31 |
| MOTT DAVID M | 10% Owner | 10 | $4.40M | $5.7K | 2016-10-31 |
| BARRETT M JAMES | 10% Owner | 10 | $4.40M | $5.7K | 2016-10-31 |
| BARRIS PETER J | 10% Owner | 10 | $4.40M | $5.7K | 2016-10-31 |
Trade history
| Insider | Role | Code | Trade | Filed | Shares | Price | Value | Owned after | |
|---|---|---|---|---|---|---|---|---|---|
| Brennan Aoife | Director | D To issuer deriv | 2020-04-02 | 2020-04-03 | 25,000 | — | $0 | 0 | SEC↗ |
| Brennan Aoife | Director | D To issuer deriv | 2020-04-02 | 2020-04-03 | 15,000 | — | $0 | 0 | SEC↗ |
| Heft Robert | Director | D To issuer deriv | 2020-04-02 | 2020-04-03 | 22,857 | — | $0 | 0 | SEC↗ |
| Heft Robert | Director | D To issuer deriv | 2020-04-02 | 2020-04-03 | 15,000 | — | $0 | 0 | SEC↗ |
| Heft Robert | Director | D To issuer deriv | 2020-04-02 | 2020-04-03 | 15,000 | — | $0 | 0 | SEC↗ |
| Heft Robert | Director | D To issuer deriv | 2020-04-02 | 2020-04-03 | 15,000 | — | $0 | 0 | SEC↗ |
| Shah Rajeev M. | Director, 10% Owner | D To issuer deriv | 2020-04-02 | 2020-04-03 | 15,000 | — | $0 | 0 | SEC↗ |
| Shah Rajeev M. | Director, 10% Owner | D To issuer deriv | 2020-04-02 | 2020-04-03 | 15,000 | — | $0 | 0 | SEC↗ |
| Shah Rajeev M. | Director, 10% Owner | D To issuer deriv | 2020-04-02 | 2020-04-03 | 15,000 | — | $0 | 0 | SEC↗ |
| King John C | Chief Commercial Officer | D To issuer deriv | 2020-04-02 | 2020-04-03 | 30,658 | — | $0 | 0 | SEC↗ |
| King John C | Chief Commercial Officer | D To issuer deriv | 2020-04-02 | 2020-04-03 | 107,000 | — | $0 | 0 | SEC↗ |
| King John C | Chief Commercial Officer | D To issuer deriv | 2020-04-02 | 2020-04-03 | 190,000 | — | $0 | 0 | SEC↗ |
| PEARSON TIMOTHY R | Director | D To issuer deriv | 2020-04-02 | 2020-04-03 | 15,000 | — | $0 | 0 | SEC↗ |
| PEARSON TIMOTHY R | Director | D To issuer deriv | 2020-04-02 | 2020-04-03 | 15,000 | — | $0 | 0 | SEC↗ |
| PEARSON TIMOTHY R | Director | D To issuer deriv | 2020-04-02 | 2020-04-03 | 22,857 | — | $0 | 0 | SEC↗ |
| PEARSON TIMOTHY R | Director | D To issuer deriv | 2020-04-02 | 2020-04-03 | 15,000 | — | $0 | 0 | SEC↗ |
| Cumbo Alexander | Director | D To issuer deriv | 2020-04-02 | 2020-04-03 | 25,000 | — | $0 | 0 | SEC↗ |
| Cumbo Alexander | Director | D To issuer deriv | 2020-04-02 | 2020-04-03 | 15,000 | — | $0 | 0 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | D To issuer deriv | 2020-04-02 | 2020-04-03 | 73,654 | — | $0 | 0 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | D To issuer deriv | 2020-04-02 | 2020-04-03 | 11,110 | — | $0 | 0 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | D To issuer deriv | 2020-04-02 | 2020-04-03 | 90,000 | — | $0 | 0 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | D To issuer deriv | 2020-04-02 | 2020-04-03 | 62,500 | — | $0 | 0 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | D To issuer deriv | 2020-04-02 | 2020-04-03 | 133,000 | — | $0 | 0 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | D To issuer deriv | 2020-04-02 | 2020-04-03 | 10,416 | — | $0 | 0 | SEC↗ |
| Read Simon | Chief Scientific Officer | D To issuer deriv | 2020-04-02 | 2020-04-03 | 107,000 | — | $0 | 0 | SEC↗ |
| Read Simon | Chief Scientific Officer | D To issuer deriv | 2020-04-02 | 2020-04-03 | 9,166 | — | $0 | 0 | SEC↗ |
| Read Simon | Chief Scientific Officer | D To issuer deriv | 2020-04-02 | 2020-04-03 | 55,000 | — | $0 | 0 | SEC↗ |
| Read Simon | Chief Scientific Officer | D To issuer deriv | 2020-04-02 | 2020-04-03 | 46,434 | — | $0 | 0 | SEC↗ |
| Read Simon | Chief Scientific Officer | D To issuer deriv | 2020-04-02 | 2020-04-03 | 26,422 | — | $0 | 0 | SEC↗ |
| Read Simon | Chief Scientific Officer | D To issuer deriv | 2020-04-02 | 2020-04-03 | 25,000 | — | $0 | 0 | SEC↗ |
| Read Simon | Chief Scientific Officer | D To issuer deriv | 2020-04-02 | 2020-04-03 | 67,500 | — | $0 | 0 | SEC↗ |
| Ricardo Alonso | See Remarks | D To issuer deriv | 2020-04-02 | 2020-04-03 | 31,428 | — | $0 | 0 | SEC↗ |
| Ricardo Alonso | See Remarks | D To issuer deriv | 2020-04-02 | 2020-04-03 | 60,000 | — | $0 | 0 | SEC↗ |
| Ricardo Alonso | See Remarks | D To issuer deriv | 2020-04-02 | 2020-04-03 | 26,250 | — | $0 | 0 | SEC↗ |
| Ricardo Alonso | See Remarks | D To issuer deriv | 2020-04-02 | 2020-04-03 | 107,000 | — | $0 | 0 | SEC↗ |
| Ricardo Alonso | See Remarks | D To issuer deriv | 2020-04-02 | 2020-04-03 | 4,375 | — | $0 | 0 | SEC↗ |
| Ricardo Alonso | See Remarks | D To issuer deriv | 2020-04-02 | 2020-04-03 | 30,000 | — | $0 | 0 | SEC↗ |
| Ricardo Alonso | See Remarks | D To issuer deriv | 2020-04-02 | 2020-04-03 | 14,285 | — | $0 | 0 | SEC↗ |
| Ricardo Alonso | See Remarks | D To issuer deriv | 2020-04-02 | 2020-04-03 | 2,857 | — | $0 | 0 | SEC↗ |
| Lubner David Charles | Executive VP and CFO | D To issuer deriv | 2020-04-02 | 2020-04-03 | 115,572 | — | $0 | 0 | SEC↗ |
| Lubner David Charles | Executive VP and CFO | D To issuer deriv | 2020-04-02 | 2020-04-03 | 92,283 | — | $0 | 0 | SEC↗ |
| Lubner David Charles | Executive VP and CFO | D To issuer deriv | 2020-04-02 | 2020-04-03 | 28,571 | — | $0 | 0 | SEC↗ |
| Lubner David Charles | Executive VP and CFO | D To issuer deriv | 2020-04-02 | 2020-04-03 | 112,500 | — | $0 | 0 | SEC↗ |
| Lubner David Charles | Executive VP and CFO | D To issuer deriv | 2020-04-02 | 2020-04-03 | 62,500 | — | $0 | 0 | SEC↗ |
| Lubner David Charles | Executive VP and CFO | D To issuer deriv | 2020-04-02 | 2020-04-03 | 10,416 | — | $0 | 0 | SEC↗ |
| Lubner David Charles | Executive VP and CFO | D To issuer deriv | 2020-04-02 | 2020-04-03 | 133,000 | — | $0 | 0 | SEC↗ |
| Treco Douglas A | President and CEO | D To issuer deriv | 2020-04-02 | 2020-04-03 | 125,000 | — | $0 | 0 | SEC↗ |
| Treco Douglas A | President and CEO | D To issuer deriv | 2020-04-02 | 2020-04-03 | 139,371 | — | $0 | 0 | SEC↗ |
| Treco Douglas A | President and CEO | D To issuer deriv | 2020-04-02 | 2020-04-03 | 241,460 | — | $0 | 0 | SEC↗ |
| Treco Douglas A | President and CEO | D To issuer deriv | 2020-04-02 | 2020-04-03 | 164,285 | — | $0 | 0 | SEC↗ |
| Treco Douglas A | President and CEO | D To issuer deriv | 2020-04-02 | 2020-04-03 | 20,833 | — | $0 | 0 | SEC↗ |
| Treco Douglas A | President and CEO | D To issuer deriv | 2020-04-02 | 2020-04-03 | 311,000 | — | $0 | 0 | SEC↗ |
| Treco Douglas A | President and CEO | D To issuer deriv | 2020-04-02 | 2020-04-03 | 225,000 | — | $0 | 0 | SEC↗ |
| Mathers Edward T | Director | D To issuer deriv | 2020-04-02 | 2020-04-03 | 15,000 | — | $0 | 0 | SEC↗ |
| Mathers Edward T | Director | D To issuer deriv | 2020-04-02 | 2020-04-03 | 15,000 | — | $0 | 0 | SEC↗ |
| Mathers Edward T | Director | D To issuer deriv | 2020-04-02 | 2020-04-03 | 15,000 | — | $0 | 0 | SEC↗ |
| RA Capital Healthcare Fund LP | Director, 10% Owner | D To issuer | 2020-04-02 | 2020-04-03 | 4,858,260 | $48.00 | $233.20M | 0 | SEC↗ |
| Shah Rajeev M. | Director, 10% Owner | D To issuer | 2020-04-02 | 2020-04-03 | 4,858,260 | $48.00 | $233.20M | 0 | SEC↗ |
| King John C | Chief Commercial Officer | D To issuer | 2020-04-02 | 2020-04-03 | 10,823 | $48.00 | $519.5K | 0 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | D To issuer | 2020-04-02 | 2020-04-03 | 14,492 | $48.00 | $695.6K | 0 | SEC↗ |
| Read Simon | Chief Scientific Officer | D To issuer | 2020-04-02 | 2020-04-03 | 12,595 | $48.00 | $604.6K | 0 | SEC↗ |
| Ricardo Alonso | See Remarks | D To issuer | 2020-04-02 | 2020-04-03 | 2,973 | $48.00 | $142.7K | 0 | SEC↗ |
| Lubner David Charles | Executive VP and CFO | D To issuer | 2020-04-02 | 2020-04-03 | 15,622 | $48.00 | $749.9K | 0 | SEC↗ |
| Treco Douglas A | President and CEO | D To issuer | 2020-04-02 | 2020-04-03 | 234,707 | $48.00 | $11.27M | 0 | SEC↗ |
| NEA 13 GP, Ltd | 10% Owner | D To issuer | 2020-04-02 | 2020-04-03 | 6,135,234 | — | $0 | 0 | SEC↗ |
| Ricardo Alonso | See Remarks | S Sale | 2020-03-17 | 2020-03-18 | 2,288 | $44.25 | $101.2K | 0 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise deriv | 2020-03-16 | 2020-03-18 | 9,206 | — | $0 | 73,654 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise deriv | 2020-03-16 | 2020-03-18 | 1,389 | — | $0 | 11,110 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | S Sale | 2020-03-16 | 2020-03-18 | 10,595 | $45.16 | $478.5K | 7,132 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise | 2020-03-16 | 2020-03-18 | 1,389 | $5.60 | $7.8K | 8,521 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise | 2020-03-16 | 2020-03-18 | 9,206 | $5.60 | $51.6K | 17,727 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise deriv | 2020-02-18 | 2020-02-20 | 1,389 | — | $0 | 12,499 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise deriv | 2020-02-18 | 2020-02-20 | 9,206 | — | $0 | 82,860 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | S Sale | 2020-02-18 | 2020-02-20 | 10,595 | $46.61 | $493.8K | 7,132 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise | 2020-02-18 | 2020-02-20 | 9,206 | $5.60 | $51.6K | 17,727 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise | 2020-02-18 | 2020-02-20 | 1,389 | $5.60 | $7.8K | 8,521 | SEC↗ |
| Ricardo Alonso | See Remarks | S Sale | 2020-01-17 | 2020-01-21 | 2,285 | $47.02 | $107.4K | 2,288 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise deriv | 2020-01-15 | 2020-01-16 | 9,206 | — | $0 | 92,066 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise deriv | 2020-01-15 | 2020-01-16 | 1,389 | — | $0 | 13,888 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise | 2020-01-15 | 2020-01-16 | 9,206 | $5.60 | $51.6K | 17,727 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise | 2020-01-15 | 2020-01-16 | 1,389 | $5.60 | $7.8K | 8,521 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | S Sale | 2020-01-15 | 2020-01-16 | 10,595 | $46.95 | $497.4K | 7,132 | SEC↗ |
| Read Simon | Chief Scientific Officer | M Exercise deriv | 2019-12-17 | 2019-12-18 | 10,000 | — | $0 | 46,142 | SEC↗ |
| Read Simon | Chief Scientific Officer | S Sale | 2019-12-17 | 2019-12-18 | 10,000 | $47.08 | $470.8K | 6,234 | SEC↗ |
| Read Simon | Chief Scientific Officer | M Exercise | 2019-12-17 | 2019-12-18 | 10,000 | $2.87 | $28.7K | 16,234 | SEC↗ |
| Ricardo Alonso | See Remarks | S Sale | 2019-12-17 | 2019-12-18 | 2,285 | $47.08 | $107.6K | 4,573 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise deriv | 2019-12-16 | 2019-12-18 | 1,389 | — | $0 | 15,277 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise deriv | 2019-12-16 | 2019-12-18 | 9,206 | — | $0 | 101,272 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise | 2019-12-16 | 2019-12-18 | 9,206 | $5.60 | $51.6K | 17,727 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise | 2019-12-16 | 2019-12-18 | 1,389 | $5.60 | $7.8K | 8,521 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | S Sale | 2019-12-16 | 2019-12-18 | 10,595 | $47.23 | $500.4K | 7,132 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise deriv | 2019-11-15 | 2019-11-18 | 9,206 | — | $0 | 110,478 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise deriv | 2019-11-15 | 2019-11-18 | 1,389 | — | $0 | 16,666 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | S Sale | 2019-11-15 | 2019-11-18 | 10,595 | $46.66 | $494.4K | 7,132 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise | 2019-11-15 | 2019-11-18 | 9,206 | $5.60 | $51.6K | 17,727 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise | 2019-11-15 | 2019-11-18 | 1,389 | $5.60 | $7.8K | 8,521 | SEC↗ |
| Read Simon | Chief Scientific Officer | M Exercise deriv | 2019-11-14 | 2019-11-18 | 10,000 | — | $0 | 56,142 | SEC↗ |
| Read Simon | Chief Scientific Officer | S Sale | 2019-11-14 | 2019-11-18 | 10,000 | $46.68 | $466.8K | 6,234 | SEC↗ |
| Read Simon | Chief Scientific Officer | M Exercise | 2019-11-14 | 2019-11-18 | 10,000 | $2.87 | $28.7K | 16,234 | SEC↗ |
| Ricardo Alonso | See Remarks | S Sale | 2019-10-17 | 2019-10-17 | 2,285 | $46.70 | $106.7K | 6,858 | SEC↗ |
| Read Simon | Chief Scientific Officer | M Exercise deriv | 2019-10-16 | 2019-10-17 | 10,000 | — | $0 | 66,142 | SEC↗ |
| Read Simon | Chief Scientific Officer | M Exercise | 2019-10-16 | 2019-10-17 | 10,000 | $2.87 | $28.7K | 16,234 | SEC↗ |
| Read Simon | Chief Scientific Officer | S Sale | 2019-10-16 | 2019-10-17 | 10,000 | $46.87 | $468.7K | 6,234 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise deriv | 2019-10-15 | 2019-10-17 | 1,389 | — | $0 | 18,055 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise deriv | 2019-10-15 | 2019-10-17 | 9,206 | — | $0 | 119,684 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise | 2019-10-15 | 2019-10-17 | 9,206 | $5.60 | $51.6K | 17,727 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise | 2019-10-15 | 2019-10-17 | 1,389 | $5.60 | $7.8K | 8,521 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | S Sale | 2019-10-15 | 2019-10-17 | 10,595 | $46.89 | $496.8K | 7,132 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise deriv | 2019-09-16 | 2019-09-16 | 9,206 | — | $0 | 128,890 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise deriv | 2019-09-16 | 2019-09-16 | 1,389 | — | $0 | 19,444 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise | 2019-09-16 | 2019-09-16 | 1,389 | $5.60 | $7.8K | 8,521 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise | 2019-09-16 | 2019-09-16 | 9,206 | $5.60 | $51.6K | 17,727 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | S Sale | 2019-09-16 | 2019-09-16 | 10,595 | $25.26 | $267.6K | 7,132 | SEC↗ |
| Read Simon | Chief Scientific Officer | M Exercise deriv | 2019-09-12 | 2019-09-16 | 10,000 | — | $0 | 76,142 | SEC↗ |
| Read Simon | Chief Scientific Officer | M Exercise | 2019-09-12 | 2019-09-16 | 10,000 | $2.87 | $28.7K | 16,234 | SEC↗ |
| Read Simon | Chief Scientific Officer | S Sale | 2019-09-12 | 2019-09-16 | 10,000 | $25.41 | $254.1K | 6,234 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise deriv | 2019-08-23 | 2019-08-27 | 1,389 | — | $0 | 20,833 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise deriv | 2019-08-23 | 2019-08-27 | 9,206 | — | $0 | 138,096 | SEC↗ |
| Read Simon | Chief Scientific Officer | M Exercise deriv | 2019-08-23 | 2019-08-27 | 10,000 | — | $0 | 86,142 | SEC↗ |
| Ricardo Alonso | See Remarks | S Sale | 2019-08-23 | 2019-08-27 | 2,285 | $27.89 | $63.7K | 9,143 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise | 2019-08-23 | 2019-08-27 | 1,389 | $5.60 | $7.8K | 8,521 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise | 2019-08-23 | 2019-08-27 | 9,206 | $5.60 | $51.6K | 17,727 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | S Sale | 2019-08-23 | 2019-08-27 | 10,595 | $27.77 | $294.2K | 7,132 | SEC↗ |
| Read Simon | Chief Scientific Officer | M Exercise | 2019-08-23 | 2019-08-27 | 10,000 | $2.87 | $28.7K | 16,234 | SEC↗ |
| Read Simon | Chief Scientific Officer | S Sale | 2019-08-23 | 2019-08-27 | 10,000 | $27.77 | $277.7K | 6,234 | SEC↗ |
| Read Simon | Chief Scientific Officer | M Exercise deriv | 2019-07-17 | 2019-07-18 | 10,000 | — | $0 | 96,142 | SEC↗ |
| Read Simon | Chief Scientific Officer | M Exercise | 2019-07-17 | 2019-07-18 | 10,000 | $2.87 | $28.7K | 16,234 | SEC↗ |
| Read Simon | Chief Scientific Officer | S Sale | 2019-07-17 | 2019-07-18 | 10,000 | $32.95 | $329.5K | 6,234 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise deriv | 2019-07-15 | 2019-07-16 | 1,389 | — | $0 | 22,222 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise deriv | 2019-07-15 | 2019-07-16 | 9,206 | — | $0 | 147,302 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise | 2019-07-15 | 2019-07-16 | 9,206 | $5.60 | $51.6K | 17,727 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | S Sale | 2019-07-15 | 2019-07-16 | 6,379 | $32.97 | $210.3K | 11,348 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | S Sale | 2019-07-15 | 2019-07-16 | 4,216 | $33.29 | $140.4K | 7,132 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise | 2019-07-15 | 2019-07-16 | 1,389 | $5.60 | $7.8K | 8,521 | SEC↗ |
| Ricardo Alonso | See Remarks | S Sale | 2019-06-21 | 2019-06-25 | 2,857 | $23.72 | $67.8K | 11,428 | SEC↗ |
| Read Simon | Chief Scientific Officer | M Exercise deriv | 2019-06-18 | 2019-06-19 | 10,000 | — | $0 | 106,142 | SEC↗ |
| Read Simon | Chief Scientific Officer | M Exercise | 2019-06-18 | 2019-06-19 | 10,000 | $2.87 | $28.7K | 16,234 | SEC↗ |
| Read Simon | Chief Scientific Officer | S Sale | 2019-06-18 | 2019-06-19 | 414 | $23.09 | $9.6K | 6,234 | SEC↗ |
| Read Simon | Chief Scientific Officer | S Sale | 2019-06-18 | 2019-06-19 | 9,586 | $22.21 | $212.9K | 6,648 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise deriv | 2019-06-17 | 2019-06-19 | 9,206 | — | $0 | 156,508 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise deriv | 2019-06-17 | 2019-06-19 | 1,389 | — | $0 | 23,611 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise | 2019-06-17 | 2019-06-19 | 9,206 | $5.60 | $51.6K | 17,727 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | S Sale | 2019-06-17 | 2019-06-19 | 3,411 | $21.41 | $73.0K | 14,316 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | S Sale | 2019-06-17 | 2019-06-19 | 7,184 | $22.04 | $158.3K | 7,132 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise | 2019-06-17 | 2019-06-19 | 1,389 | $5.60 | $7.8K | 8,521 | SEC↗ |
| Mathers Edward T | Director | A Award deriv | 2019-06-11 | 2019-06-13 | 15,000 | — | $0 | 15,000 | SEC↗ |
| RA Capital Healthcare Fund LP | 10% Owner | A Award deriv | 2019-06-11 | 2019-06-13 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Heft Robert | Director | A Award deriv | 2019-06-11 | 2019-06-13 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Brennan Aoife | Director | A Award deriv | 2019-06-11 | 2019-06-13 | 15,000 | — | $0 | 15,000 | SEC↗ |
| PEARSON TIMOTHY R | Director | A Award deriv | 2019-06-11 | 2019-06-13 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Cumbo Alexander | Director | A Award deriv | 2019-06-11 | 2019-06-13 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Shah Rajeev M. | Director, 10% Owner | A Award deriv | 2019-06-11 | 2019-06-13 | 15,000 | — | $0 | 15,000 | SEC↗ |
| King John C | Chief Commercial Officer | M Exercise deriv | 2019-04-16 | 2019-04-18 | 15,329 | — | $0 | 30,658 | SEC↗ |
| King John C | Chief Commercial Officer | F Tax w/h | 2019-04-16 | 2019-04-18 | 4,506 | $21.93 | $98.8K | 10,823 | SEC↗ |
| King John C | Chief Commercial Officer | M Exercise | 2019-04-16 | 2019-04-18 | 15,329 | — | $0 | 15,329 | SEC↗ |
| Treco Douglas A | President and CEO | A Award deriv | 2019-02-01 | 2019-02-05 | 311,000 | — | $0 | 311,000 | SEC↗ |
| Treco Douglas A | President and CEO | M Exercise deriv | 2019-02-01 | 2019-02-05 | 20,834 | — | $0 | 41,666 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | A Award deriv | 2019-02-01 | 2019-02-05 | 133,000 | — | $0 | 133,000 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise deriv | 2019-02-01 | 2019-02-05 | 10,417 | — | $0 | 20,833 | SEC↗ |
| Read Simon | Chief Scientific Officer | M Exercise deriv | 2019-02-01 | 2019-02-05 | 9,167 | — | $0 | 18,333 | SEC↗ |
| Read Simon | Chief Scientific Officer | A Award deriv | 2019-02-01 | 2019-02-05 | 107,000 | — | $0 | 107,000 | SEC↗ |
| Lubner David Charles | Executive V.P. & CFO | M Exercise deriv | 2019-02-01 | 2019-02-05 | 10,417 | — | $0 | 20,833 | SEC↗ |
| Lubner David Charles | Executive V.P. & CFO | A Award deriv | 2019-02-01 | 2019-02-05 | 133,000 | — | $0 | 133,000 | SEC↗ |
| King John C | Chief Commercial Officer | A Award deriv | 2019-02-01 | 2019-02-05 | 107,000 | — | $0 | 107,000 | SEC↗ |
| Treco Douglas A | President and CEO | F Tax w/h | 2019-02-01 | 2019-02-05 | 6,327 | $21.00 | $132.9K | 218,799 | SEC↗ |
| Treco Douglas A | President and CEO | M Exercise | 2019-02-01 | 2019-02-05 | 20,834 | — | $0 | 225,126 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | F Tax w/h | 2019-02-01 | 2019-02-05 | 3,285 | $21.00 | $69.0K | 7,132 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | M Exercise | 2019-02-01 | 2019-02-05 | 10,417 | — | $0 | 10,417 | SEC↗ |
| Read Simon | Chief Scientific Officer | F Tax w/h | 2019-02-01 | 2019-02-05 | 2,933 | $21.00 | $61.6K | 6,234 | SEC↗ |
| Read Simon | Chief Scientific Officer | M Exercise | 2019-02-01 | 2019-02-05 | 9,167 | — | $0 | 9,167 | SEC↗ |
| Lubner David Charles | Executive V.P. & CFO | F Tax w/h | 2019-02-01 | 2019-02-05 | 3,291 | $21.00 | $69.1K | 7,126 | SEC↗ |
| Lubner David Charles | Executive V.P. & CFO | M Exercise | 2019-02-01 | 2019-02-05 | 10,417 | — | $0 | 10,417 | SEC↗ |
| Shah Rajeev M. | Director, 10% Owner | P Buy | 2018-12-14 | 2018-12-14 | 1,006,452 | $15.50 | $15.60M | 4,858,260 | SEC↗ |
| NEA Partners 13, Limited Partn | 10% Owner | P Buy | 2018-12-14 | 2018-12-14 | 645,161 | $15.50 | $10.00M | 6,135,234 | SEC↗ |
| RA CAPITAL MANAGEMENT, LLC | Director, 10% Owner | P Buy | 2018-12-12 | 2018-12-14 | 1,006,452 | $15.50 | $15.60M | 4,858,260 | SEC↗ |
| Cumbo Alexander | Director | A Award deriv | 2018-11-14 | 2018-11-15 | 25,000 | — | $0 | 25,000 | SEC↗ |
| Brennan Aoife | Director | A Award deriv | 2018-09-21 | 2018-09-25 | 25,000 | — | $0 | 25,000 | SEC↗ |
| Kolchinsky Peter | Director, 10% Owner | A Award deriv | 2018-06-28 | 2018-11-01 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Shah Rajeev M. | Director, 10% Owner | A Award deriv | 2018-06-28 | 2018-07-02 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Bisgaard Peter | Director | A Award deriv | 2018-06-28 | 2018-07-02 | 15,000 | — | $0 | 15,000 | SEC↗ |
| PEARSON TIMOTHY R | Director | A Award deriv | 2018-06-28 | 2018-07-02 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Heft Robert | Director | A Award deriv | 2018-06-28 | 2018-07-02 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Mathers Edward T | Director | A Award deriv | 2018-06-28 | 2018-07-02 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Kolchinsky Peter | Director, 10% Owner | A Award deriv | 2018-06-28 | 2018-07-02 | 15,000 | — | $0 | 15,000 | SEC↗ |
| King John C | Chief Commercial Officer | A Award deriv | 2018-05-01 | 2018-05-02 | 45,987 | — | $0 | 45,987 | SEC↗ |
| King John C | Chief Commercial Officer | A Award deriv | 2018-05-01 | 2018-05-02 | 190,000 | — | $0 | 190,000 | SEC↗ |
| NEA 13 GP, Ltd | 10% Owner | P Buy | 2018-02-16 | 2018-02-21 | 2,000,000 | $6.00 | $12.00M | 5,490,073 | SEC↗ |
| Kolchinsky Peter | 10% Owner | P Buy | 2018-02-14 | 2018-02-16 | 2,500,000 | $6.00 | $15.00M | 3,851,808 | SEC↗ |
| Shah Rajeev M. | Director, 10% Owner | P Buy | 2018-02-14 | 2018-02-16 | 2,500,000 | $6.00 | $15.00M | 3,851,808 | SEC↗ |
| Treco Douglas A | President and CEO | A Award deriv | 2018-02-01 | 2018-02-05 | 125,000 | — | $0 | 125,000 | SEC↗ |
| Treco Douglas A | President and CEO | A Award deriv | 2018-02-01 | 2018-02-05 | 62,500 | — | $0 | 62,500 | SEC↗ |
| Lubner David Charles | Executive V.P. & CFO | A Award deriv | 2018-02-01 | 2018-02-05 | 62,500 | — | $0 | 62,500 | SEC↗ |
| Lubner David Charles | Executive V.P. & CFO | A Award deriv | 2018-02-01 | 2018-02-05 | 31,250 | — | $0 | 31,250 | SEC↗ |
| Read Simon | Chief Scientific Officer | A Award deriv | 2018-02-01 | 2018-02-05 | 27,500 | — | $0 | 27,500 | SEC↗ |
| Read Simon | Chief Scientific Officer | A Award deriv | 2018-02-01 | 2018-02-05 | 55,000 | — | $0 | 55,000 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | A Award deriv | 2018-02-01 | 2018-02-05 | 62,500 | — | $0 | 62,500 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | A Award deriv | 2018-02-01 | 2018-02-05 | 31,250 | — | $0 | 31,250 | SEC↗ |
| Bisgaard Peter | Director | A Award deriv | 2017-10-26 | 2017-10-30 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Kolchinsky Peter | Director | A Award deriv | 2017-06-20 | 2017-06-22 | 15,000 | — | $0 | 15,000 | SEC↗ |
| PEARSON TIMOTHY R | Director | A Award deriv | 2017-06-20 | 2017-06-22 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Shah Rajeev M. | Director | A Award deriv | 2017-06-20 | 2017-06-22 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Heft Robert | Director | A Award deriv | 2017-06-20 | 2017-06-22 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Mathers Edward T | Director | A Award deriv | 2017-06-20 | 2017-06-22 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Lettmann Jason | Director, 10% Owner | A Award deriv | 2017-06-20 | 2017-06-22 | 15,000 | — | $0 | 15,000 | SEC↗ |
| NOVARTIS AG | 10% Owner | S Sale | 2017-06-19 | 2017-06-20 | 3,220 | $22.02 | $70.9K | 2,251,457 | SEC↗ |
| NOVARTIS AG | 10% Owner | S Sale | 2017-06-16 | 2017-06-20 | 53,200 | $21.24 | $1.13M | 2,254,677 | SEC↗ |
| NOVARTIS AG | 10% Owner | S Sale | 2017-06-08 | 2017-06-12 | 700 | $22.00 | $15.4K | 2,307,877 | SEC↗ |
| NOVARTIS AG | 10% Owner | S Sale | 2017-06-07 | 2017-06-08 | 4,840 | $22.11 | $107.0K | 2,308,577 | SEC↗ |
| NOVARTIS AG | 10% Owner | S Sale | 2017-06-06 | 2017-06-08 | 7,274 | $22.98 | $167.2K | 2,313,417 | SEC↗ |
| Novartis Bioventures Ltd | 10% Owner | S Sale | 2017-06-05 | 2017-06-06 | 4,780 | $23.11 | $110.5K | 2,320,691 | SEC↗ |
| Novartis Bioventures Ltd | 10% Owner | S Sale | 2017-06-02 | 2017-06-06 | 14,867 | $23.47 | $348.9K | 2,325,471 | SEC↗ |
| NOVARTIS AG | 10% Owner | S Sale | 2017-06-01 | 2017-06-02 | 10,722 | $23.89 | $256.1K | 2,340,338 | SEC↗ |
| NOVARTIS AG | 10% Owner | S Sale | 2017-05-31 | 2017-06-02 | 35,539 | $23.94 | $850.8K | 2,351,060 | SEC↗ |
| NOVARTIS AG | 10% Owner | S Sale | 2017-05-26 | 2017-05-30 | 5,300 | $25.14 | $133.2K | 2,386,599 | SEC↗ |
| NOVARTIS AG | 10% Owner | S Sale | 2017-05-25 | 2017-05-30 | 53 | $25.00 | $1.3K | 2,391,899 | SEC↗ |
| NOVARTIS AG | 10% Owner | S Sale | 2017-05-24 | 2017-05-25 | 17,451 | $25.01 | $436.4K | 2,391,952 | SEC↗ |
| Novartis Bioventures Ltd | 10% Owner | S Sale | 2017-05-18 | 2017-05-22 | 9,019 | $25.50 | $230.0K | 2,409,403 | SEC↗ |
| NOVARTIS AG | 10% Owner | S Sale | 2017-05-17 | 2017-05-18 | 22,534 | $25.51 | $574.8K | 2,418,422 | SEC↗ |
| NOVARTIS AG | 10% Owner | S Sale | 2017-05-16 | 2017-05-18 | 20,081 | $26.33 | $528.7K | 2,440,956 | SEC↗ |
| NOVARTIS AG | 10% Owner | S Sale | 2017-03-01 | 2017-05-02 | 7,778 | $20.91 | $162.6K | 2,461,037 | SEC↗ |
| NOVARTIS AG | 10% Owner | S Sale | 2017-02-28 | 2017-05-02 | 7,847 | $20.86 | $163.7K | 2,468,815 | SEC↗ |
| NOVARTIS AG | 10% Owner | S Sale | 2017-02-27 | 2017-05-02 | 57,844 | $20.96 | $1.21M | 2,476,662 | SEC↗ |
| NOVARTIS AG | 10% Owner | S Sale | 2017-02-24 | 2017-05-02 | 5,398 | $20.93 | $113.0K | 2,534,506 | SEC↗ |
| NOVARTIS AG | 10% Owner | S Sale | 2017-02-23 | 2017-05-02 | 4,999 | $21.04 | $105.2K | 2,539,904 | SEC↗ |
| NOVARTIS AG | 10% Owner | S Sale | 2017-02-22 | 2017-05-02 | 749 | $21.86 | $16.4K | 2,544,903 | SEC↗ |
| Farzaneh-Far Ramin | Chief Medical Officer | A Award deriv | 2017-02-01 | 2017-02-03 | 90,000 | — | $0 | 90,000 | SEC↗ |
| Lubner David Charles | Executive V.P. & CFO | A Award deriv | 2017-02-01 | 2017-02-03 | 112,500 | — | $0 | 112,500 | SEC↗ |
| Read Simon | Chief Scientific Officer | A Award deriv | 2017-02-01 | 2017-02-03 | 67,500 | — | $0 | 67,500 | SEC↗ |
| Treco Douglas A | President & CEO | A Award deriv | 2017-02-01 | 2017-02-03 | 225,000 | — | $0 | 225,000 | SEC↗ |
| NEA 13 GP, Ltd | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 12,447,605 | — | $0 | 0 | SEC↗ |
| NEA 13 GP, Ltd | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 4,689,657 | — | $0 | 0 | SEC↗ |
| NEA 13 GP, Ltd | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 4,362,472 | — | $0 | 0 | SEC↗ |
| NEA 13 GP, Ltd | 10% Owner | X Exercise deriv | 2016-10-31 | 2016-10-31 | 80,658 | — | $0 | 0 | SEC↗ |
| BARRETT M JAMES | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 4,689,657 | — | $0 | 0 | SEC↗ |
| BARRETT M JAMES | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 12,447,605 | — | $0 | 0 | SEC↗ |
| BARRETT M JAMES | 10% Owner | X Exercise deriv | 2016-10-31 | 2016-10-31 | 80,658 | — | $0 | 0 | SEC↗ |
| BARRETT M JAMES | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 4,362,472 | — | $0 | 0 | SEC↗ |
| BARRIS PETER J | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 4,689,657 | — | $0 | 0 | SEC↗ |
| BARRIS PETER J | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 12,447,605 | — | $0 | 0 | SEC↗ |
| BARRIS PETER J | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 4,362,472 | — | $0 | 0 | SEC↗ |
| BARRIS PETER J | 10% Owner | X Exercise deriv | 2016-10-31 | 2016-10-31 | 80,658 | — | $0 | 0 | SEC↗ |
| BASKETT FOREST | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 12,447,605 | — | $0 | 0 | SEC↗ |
| BASKETT FOREST | 10% Owner | X Exercise deriv | 2016-10-31 | 2016-10-31 | 80,658 | — | $0 | 0 | SEC↗ |
| BASKETT FOREST | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 4,689,657 | — | $0 | 0 | SEC↗ |
| BASKETT FOREST | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 4,362,472 | — | $0 | 0 | SEC↗ |
| KERINS PATRICK J | 10% Owner | X Exercise deriv | 2016-10-31 | 2016-10-31 | 80,658 | — | $0 | 0 | SEC↗ |
| KERINS PATRICK J | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 12,447,605 | — | $0 | 0 | SEC↗ |
| KERINS PATRICK J | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 4,689,657 | — | $0 | 0 | SEC↗ |
| KERINS PATRICK J | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 4,362,472 | — | $0 | 0 | SEC↗ |
| NOVARTIS AG | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 3,402,729 | — | $0 | 0 | SEC↗ |
| NOVARTIS AG | 10% Owner | X Exercise deriv | 2016-10-31 | 2016-10-31 | 62,914 | — | $0 | 0 | SEC↗ |
| NOVARTIS AG | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 9,728,589 | — | $0 | 0 | SEC↗ |
| NOVARTIS AG | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 3,657,932 | — | $0 | 0 | SEC↗ |
| KOLLURI KRISHNA KITTU | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 4,362,472 | — | $0 | 0 | SEC↗ |
| KOLLURI KRISHNA KITTU | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 4,689,657 | — | $0 | 0 | SEC↗ |
| KOLLURI KRISHNA KITTU | 10% Owner | X Exercise deriv | 2016-10-31 | 2016-10-31 | 80,658 | — | $0 | 0 | SEC↗ |
| KOLLURI KRISHNA KITTU | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 12,447,605 | — | $0 | 0 | SEC↗ |
| MOTT DAVID M | 10% Owner | X Exercise deriv | 2016-10-31 | 2016-10-31 | 80,658 | — | $0 | 0 | SEC↗ |
| MOTT DAVID M | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 4,689,657 | — | $0 | 0 | SEC↗ |
| MOTT DAVID M | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 12,447,605 | — | $0 | 0 | SEC↗ |
| MOTT DAVID M | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 4,362,472 | — | $0 | 0 | SEC↗ |
| Lettmann Jason | Director | C Conversion deriv | 2016-10-31 | 2016-10-31 | 3,798,914 | — | $0 | 0 | SEC↗ |
| Lettmann Jason | Director | C Conversion deriv | 2016-10-31 | 2016-10-31 | 481,503 | — | $0 | 0 | SEC↗ |
| Lettmann Jason | Director | C Conversion deriv | 2016-10-31 | 2016-10-31 | 3,664,071 | — | $0 | 0 | SEC↗ |
| Lettmann Jason | Director | C Conversion deriv | 2016-10-31 | 2016-10-31 | 3,408,439 | — | $0 | 0 | SEC↗ |
| Lettmann Jason | Director | C Conversion deriv | 2016-10-31 | 2016-10-31 | 3,533,875 | — | $0 | 0 | SEC↗ |
| Lettmann Jason | Director | C Conversion deriv | 2016-10-31 | 2016-10-31 | 9,744,916 | — | $0 | 0 | SEC↗ |
| Lettmann Jason | Director | X Exercise deriv | 2016-10-31 | 2016-10-31 | 63,019 | — | $0 | 0 | SEC↗ |
| Lettmann Jason | Director | C Conversion deriv | 2016-10-31 | 2016-10-31 | 517,617 | — | $0 | 0 | SEC↗ |
| SANDELL SCOTT D | 10% Owner | X Exercise deriv | 2016-10-31 | 2016-10-31 | 80,658 | — | $0 | 0 | SEC↗ |
| SANDELL SCOTT D | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 12,447,605 | — | $0 | 0 | SEC↗ |
| SANDELL SCOTT D | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 4,362,472 | — | $0 | 0 | SEC↗ |
| SANDELL SCOTT D | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 4,689,657 | — | $0 | 0 | SEC↗ |
| Viswanathan Ravi | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 4,362,472 | — | $0 | 0 | SEC↗ |
| Viswanathan Ravi | 10% Owner | X Exercise deriv | 2016-10-31 | 2016-10-31 | 80,658 | — | $0 | 0 | SEC↗ |
| Viswanathan Ravi | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 12,447,605 | — | $0 | 0 | SEC↗ |
| Viswanathan Ravi | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 4,689,657 | — | $0 | 0 | SEC↗ |
| MORGENTHALER VENTURE PARTNERS | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 3,664,071 | — | $0 | 0 | SEC↗ |
| MORGENTHALER VENTURE PARTNERS | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 9,744,916 | — | $0 | 0 | SEC↗ |
| MORGENTHALER VENTURE PARTNERS | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 3,408,439 | — | $0 | 0 | SEC↗ |
| MORGENTHALER VENTURE PARTNERS | 10% Owner | X Exercise deriv | 2016-10-31 | 2016-10-31 | 63,019 | — | $0 | 0 | SEC↗ |
| Weller Harry R | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 12,447,605 | — | $0 | 0 | SEC↗ |
| Weller Harry R | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 4,362,472 | — | $0 | 0 | SEC↗ |
| Weller Harry R | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 4,689,657 | — | $0 | 0 | SEC↗ |
| Weller Harry R | 10% Owner | X Exercise deriv | 2016-10-31 | 2016-10-31 | 80,658 | — | $0 | 0 | SEC↗ |
| Lubner David Charles | EVP & CFO | A Award deriv | 2016-10-31 | 2016-10-31 | 29,285 | — | $0 | 29,285 | SEC↗ |
| RA Capital Healthcare Fund LP | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 4,316,531 | — | $0 | 0 | SEC↗ |
| RA Capital Healthcare Fund LP | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-10-31 | 4,015,378 | — | $0 | 0 | SEC↗ |
| Shah Rajeev M. | Director | C Conversion deriv | 2016-10-31 | 2016-10-31 | 4,316,531 | — | $0 | 0 | SEC↗ |
| Shah Rajeev M. | Director | C Conversion deriv | 2016-10-31 | 2016-10-31 | 4,015,378 | — | $0 | 0 | SEC↗ |
| Novo A/S | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-11-02 | 860,438 | — | $0 | 0 | SEC↗ |
| Novo A/S | 10% Owner | C Conversion deriv | 2016-10-31 | 2016-11-02 | 924,970 | — | $0 | 0 | SEC↗ |
| NEA 13 GP, Ltd | 10% Owner | P Buy | 2016-10-31 | 2016-10-31 | 338,462 | $13.00 | $4.40M | 3,490,073 | SEC↗ |
| NEA 13 GP, Ltd | 10% Owner | C Conversion | 2016-10-31 | 2016-10-31 | 623,210 | — | $0 | 3,151,611 | SEC↗ |
| NEA 13 GP, Ltd | 10% Owner | C Conversion | 2016-10-31 | 2016-10-31 | 669,951 | — | $0 | 2,528,401 | SEC↗ |
| NEA 13 GP, Ltd | 10% Owner | C Conversion | 2016-10-31 | 2016-10-31 | 1,778,227 | — | $0 | 1,858,450 | SEC↗ |
| NEA 13 GP, Ltd | 10% Owner | S Sale | 2016-10-31 | 2016-10-31 | 435 | $13.00 | $5.7K | 80,223 | SEC↗ |
| NEA 13 GP, Ltd | 10% Owner | X Exercise | 2016-10-31 | 2016-10-31 | 80,658 | $0.07 | $5.6K | 80,658 | SEC↗ |
| BARRETT M JAMES | 10% Owner | P Buy | 2016-10-31 | 2016-10-31 | 338,462 | $13.00 | $4.40M | 3,490,073 | SEC↗ |
| BARRETT M JAMES | 10% Owner | C Conversion | 2016-10-31 | 2016-10-31 | 623,210 | — | $0 | 3,151,611 | SEC↗ |