RVMD

Revolution Medicines, Inc.CIK 1628171 ☆ Sign in to watch Congress trades

Open-mkt buys · 90d

—

0 trades · 0 insiders

Open-mkt sales · 90d

$155.17M

154 trades · 9 insiders

Net · 90d

$-155.17M

Insiders on file

AI insights for RVMD PRO

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AI insights for RVMD

Insider sentiment score with a plain-English explanation, conviction score on every buy, and how the stock performed 30 and 90 days after past insider buys.

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Daily buy vs sell · 90 days

■ Open-market buys (P) ■ Open-market sales (S) · daily dollar value by transaction date

Insiders

Insider	Role	Trades	Bought	Sold	Last trade
Mancini Anthony	See Remarks	49	$0	$14.82M	2026-10-26
Sandler Alan B.	Chief Development Officer	11	$0	$1.41M	2026-09-29
Cislini Jeff	SVP & General Counsel	75	$0	$30.15M	2026-09-25
ANDERSON ELIZABETH M	Director	35	$0	$4.34M	2026-09-22
Anders Jack	See Remarks	84	$0	$11.57M	2026-09-16
Kelsey Stephen Michael	See Remarks	166	$0	$60.17M	2026-09-16
Horn Margaret A	See Remarks	112	$0	$38.82M	2026-09-16
GOLDSMITH MARK A	See Remarks, Director	268	$0	$101.85M	2026-09-16
Kim Lorence H.	Director	41	$1.00M	$29.93M	2026-09-08
Patel Sushil	Director	32	$0	$1.49M	2026-06-29
Borellini Flavia	Director	14	$0	$0	2026-06-18
Clyburn Frank	Director	7	$0	$0	2026-06-18
Horning Sandra	Director	13	$0	$0	2026-06-18
Borisy Alexis	Director	18	$0	$0	2026-06-18
Wei Lin	Chief Medical Officer	8	$0	$600.7K	2026-03-17
Wang Xiaolin	See Remarks	22	$0	$284.1K	2026-03-17
Schroeder Thilo	Director	44	$123.30M	$0	2024-12-05
Weber Barbara	Director	46	$0	$1.90M	2024-10-08
SCHMIDT ERIC THOMAS	Director	8	$0	$0	2023-06-08
Exter Neil	Director	17	$0	$0	2022-06-16
TEPPER ROBERT I	10% Owner	9	$0	$24.91M	2022-06-08
Miller Vincent A.	Director	12	$0	$613.7K	2021-06-22
TRV GP II, LLC	10% Owner	2	$0	$41.76M	2021-05-26
Svennilson Peter	Director, 10% Owner	27	$0	$84.23M	2021-04-28
Third Rock Ventures III, L.P.	10% Owner	2	$0	$0	2021-02-24
LEVIN MARK J	10% Owner	1	$0	$0	2020-12-02
COLUMN GROUP III-A, LP	10% Owner	2	$0	$73.79M	2020-11-16
COLUMN GROUP III, LP	10% Owner	3	$0	$0	2020-06-17
COLUMN GROUP III GP, LP	10% Owner	4	$0	$0	2020-02-18
Third Rock Ventures IV, L.P.	10% Owner	4	$0	$0	2020-02-18
DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C)	10% Owner	6	$10.20M	$0	2020-02-18
Lasky Laurence	Director	1	$0	$0	2020-02-12

Trade history

Insider	Role	Code	Trade	Filed	Shares	Price	Value	Owned after
Mancini Anthony	See Remarks	M Exercise deriv	2026-10-26	2026-10-28	2,310	—	$0	91,315	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-10-26	2026-10-28	2,310	$186.99	$431.9K	39,765	SEC↗
Mancini Anthony	See Remarks	M Exercise	2026-10-26	2026-10-28	2,310	$33.62	$77.7K	42,075	SEC↗
Sandler Alan B.	Chief Development Officer	M Exercise deriv	2026-09-29	2026-10-01	6,000	—	$0	161,300	SEC↗
Sandler Alan B.	Chief Development Officer	S Sale	2026-09-29	2026-10-01	301	$204.72	$61.6K	52,559	SEC↗
Sandler Alan B.	Chief Development Officer	S Sale	2026-09-29	2026-10-01	1,199	$203.91	$244.5K	52,860	SEC↗
Sandler Alan B.	Chief Development Officer	S Sale	2026-09-29	2026-10-01	1,000	$202.81	$202.8K	54,059	SEC↗
Sandler Alan B.	Chief Development Officer	S Sale	2026-09-29	2026-10-01	1,609	$201.72	$324.6K	55,059	SEC↗
Sandler Alan B.	Chief Development Officer	S Sale	2026-09-29	2026-10-01	2,200	$200.82	$441.8K	56,668	SEC↗
Sandler Alan B.	Chief Development Officer	M Exercise	2026-09-29	2026-10-01	6,000	$58.84	$353.0K	58,868	SEC↗
Mancini Anthony	See Remarks	M Exercise deriv	2026-09-25	2026-09-28	3,121	—	$0	93,625	SEC↗
Mancini Anthony	See Remarks	M Exercise	2026-09-25	2026-09-28	3,121	$33.62	$104.9K	42,886	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-09-25	2026-09-28	3,121	$200.54	$625.9K	39,765	SEC↗
Cislini Jeff	SVP & General Counsel	S Sale	2026-09-25	2026-09-29	765	$207.32	$158.6K	51,776	SEC↗
Mancini Anthony	See Remarks	M Exercise deriv	2026-09-25	2026-09-28	3,121	—	$0	93,625	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-09-25	2026-09-28	3,121	$200.54	$625.9K	39,765	SEC↗
Mancini Anthony	See Remarks	M Exercise	2026-09-25	2026-09-28	3,121	$33.62	$104.9K	42,886	SEC↗
Cislini Jeff	SVP & General Counsel	S Sale	2026-09-25	2026-09-29	765	$207.32	$158.6K	51,776	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-09-24	2026-09-28	587	$200.00	$117.4K	39,765	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-09-24	2026-09-28	587	$200.00	$117.4K	39,765	SEC↗
ANDERSON ELIZABETH M	Director	M Exercise deriv	2026-09-22	2026-09-24	5,070	—	$0	1,095	SEC↗
ANDERSON ELIZABETH M	Director	S Sale	2026-09-22	2026-09-24	1,500	$194.59	$291.9K	4,433	SEC↗
ANDERSON ELIZABETH M	Director	M Exercise	2026-09-22	2026-09-24	5,070	$1.12	$5.7K	14,476	SEC↗
ANDERSON ELIZABETH M	Director	S Sale	2026-09-22	2026-09-24	910	$191.85	$174.6K	13,566	SEC↗
ANDERSON ELIZABETH M	Director	S Sale	2026-09-22	2026-09-24	4,985	$192.54	$959.8K	8,581	SEC↗
ANDERSON ELIZABETH M	Director	S Sale	2026-09-22	2026-09-24	2,648	$193.44	$512.2K	5,933	SEC↗
ANDERSON ELIZABETH M	Director	S Sale	2026-09-22	2026-09-24	100	$195.15	$19.5K	4,333	SEC↗
ANDERSON ELIZABETH M	Director	M Exercise deriv	2026-09-22	2026-09-24	5,070	—	$0	1,095	SEC↗
ANDERSON ELIZABETH M	Director	S Sale	2026-09-22	2026-09-24	100	$195.15	$19.5K	4,333	SEC↗
ANDERSON ELIZABETH M	Director	S Sale	2026-09-22	2026-09-24	1,500	$194.59	$291.9K	4,433	SEC↗
ANDERSON ELIZABETH M	Director	S Sale	2026-09-22	2026-09-24	2,648	$193.44	$512.2K	5,933	SEC↗
ANDERSON ELIZABETH M	Director	S Sale	2026-09-22	2026-09-24	4,985	$192.54	$959.8K	8,581	SEC↗
ANDERSON ELIZABETH M	Director	S Sale	2026-09-22	2026-09-24	910	$191.85	$174.6K	13,566	SEC↗
ANDERSON ELIZABETH M	Director	M Exercise	2026-09-22	2026-09-24	5,070	$1.12	$5.7K	14,476	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-09-18	2026-09-22	1,764	$196.94	$347.4K	40,352	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-09-18	2026-09-22	1,764	$196.94	$347.4K	40,352	SEC↗
Anders Jack	Chief Financial Officer	S Sale	2026-09-16	2026-09-18	61	$195.00	$11.9K	123,208	SEC↗
Anders Jack	Chief Financial Officer	S Sale	2026-09-16	2026-09-18	3,992	$199.30	$795.6K	119,216	SEC↗
Cislini Jeff	SVP & General Counsel	S Sale	2026-09-16	2026-09-18	3,314	$199.30	$660.5K	52,541	SEC↗
Cislini Jeff	SVP & General Counsel	S Sale	2026-09-16	2026-09-18	52	$195.01	$10.1K	55,855	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-09-16	2026-09-18	13,775	$199.30	$2.75M	253,342	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-09-16	2026-09-18	213	$195.01	$41.5K	267,117	SEC↗
Horn Margaret A	Chief Operating Officer	S Sale	2026-09-16	2026-09-18	76	$195.01	$14.8K	154,571	SEC↗
Horn Margaret A	Chief Operating Officer	S Sale	2026-09-16	2026-09-18	4,891	$199.30	$974.8K	149,680	SEC↗
Kelsey Stephen Michael	See Remarks	S Sale	2026-09-16	2026-09-18	5,484	$199.30	$1.09M	286,307	SEC↗
Kelsey Stephen Michael	See Remarks	S Sale	2026-09-16	2026-09-18	85	$195.01	$16.6K	291,791	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-09-16	2026-09-18	27	$195.05	$5.3K	43,863	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-09-16	2026-09-18	1,747	$199.30	$348.2K	42,116	SEC↗
Sandler Alan B.	Chief Development Officer	S Sale	2026-09-16	2026-09-18	5	$194.96	$975	53,204	SEC↗
Sandler Alan B.	Chief Development Officer	S Sale	2026-09-16	2026-09-18	336	$199.30	$67.0K	52,868	SEC↗
Sandler Alan B.	Chief Development Officer	S Sale	2026-09-16	2026-09-18	336	$199.30	$67.0K	52,868	SEC↗
Sandler Alan B.	Chief Development Officer	S Sale	2026-09-16	2026-09-18	5	$194.96	$975	53,204	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-09-16	2026-09-18	1,747	$199.30	$348.2K	42,116	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-09-16	2026-09-18	27	$195.05	$5.3K	43,863	SEC↗
Kelsey Stephen Michael	See Remarks	S Sale	2026-09-16	2026-09-18	5,484	$199.30	$1.09M	286,307	SEC↗
Kelsey Stephen Michael	See Remarks	S Sale	2026-09-16	2026-09-18	85	$195.01	$16.6K	291,791	SEC↗
Horn Margaret A	Chief Operating Officer	S Sale	2026-09-16	2026-09-18	4,891	$199.30	$974.8K	149,680	SEC↗
Horn Margaret A	Chief Operating Officer	S Sale	2026-09-16	2026-09-18	76	$195.01	$14.8K	154,571	SEC↗
GOLDSMITH MARK A	See Remarks, Director	S Sale	2026-09-16	2026-09-18	13,775	$199.30	$2.75M	253,342	SEC↗
GOLDSMITH MARK A	See Remarks, Director	S Sale	2026-09-16	2026-09-18	213	$195.01	$41.5K	267,117	SEC↗
Cislini Jeff	SVP & General Counsel	S Sale	2026-09-16	2026-09-18	3,314	$199.30	$660.5K	52,541	SEC↗
Cislini Jeff	SVP & General Counsel	S Sale	2026-09-16	2026-09-18	52	$195.01	$10.1K	55,855	SEC↗
Anders Jack	Chief Financial Officer	S Sale	2026-09-16	2026-09-18	3,992	$199.30	$795.6K	119,216	SEC↗
Anders Jack	Chief Financial Officer	S Sale	2026-09-16	2026-09-18	61	$195.00	$11.9K	123,208	SEC↗
Kelsey Stephen Michael	See Remarks	M Exercise deriv	2026-09-11	2026-09-15	52,500	$42.45	$2.23M	0	SEC↗
Kelsey Stephen Michael	See Remarks	M Exercise deriv	2026-09-11	2026-09-15	40,031	$40.74	$1.63M	88,069	SEC↗
Kelsey Stephen Michael	See Remarks	M Exercise	2026-09-11	2026-09-15	40,031	$40.74	$1.63M	384,407	SEC↗
Kelsey Stephen Michael	See Remarks	M Exercise	2026-09-11	2026-09-15	52,500	$42.45	$2.23M	344,376	SEC↗
Kelsey Stephen Michael	See Remarks	S Sale	2026-09-11	2026-09-15	800	$198.55	$158.8K	383,607	SEC↗
Kelsey Stephen Michael	See Remarks	S Sale	2026-09-11	2026-09-15	11,833	$200.11	$2.37M	371,774	SEC↗
Kelsey Stephen Michael	See Remarks	S Sale	2026-09-11	2026-09-15	13,368	$200.78	$2.68M	358,406	SEC↗
Kelsey Stephen Michael	See Remarks	S Sale	2026-09-11	2026-09-15	21,447	$201.75	$4.33M	336,959	SEC↗
Kelsey Stephen Michael	See Remarks	S Sale	2026-09-11	2026-09-15	18,869	$203.06	$3.83M	318,090	SEC↗
Kelsey Stephen Michael	See Remarks	S Sale	2026-09-11	2026-09-15	17,949	$203.87	$3.66M	300,141	SEC↗
Kelsey Stephen Michael	See Remarks	S Sale	2026-09-11	2026-09-15	4,995	$204.84	$1.02M	295,146	SEC↗
Kelsey Stephen Michael	See Remarks	S Sale	2026-09-11	2026-09-15	3,270	$205.81	$673.0K	291,876	SEC↗
Kelsey Stephen Michael	See Remarks	M Exercise deriv	2026-09-11	2026-09-15	40,031	$40.74	$1.63M	88,069	SEC↗
Kelsey Stephen Michael	See Remarks	M Exercise deriv	2026-09-11	2026-09-15	52,500	$42.45	$2.23M	0	SEC↗
Kelsey Stephen Michael	See Remarks	S Sale	2026-09-11	2026-09-15	3,270	$205.81	$673.0K	291,876	SEC↗
Kelsey Stephen Michael	See Remarks	S Sale	2026-09-11	2026-09-15	4,995	$204.84	$1.02M	295,146	SEC↗
Kelsey Stephen Michael	See Remarks	S Sale	2026-09-11	2026-09-15	17,949	$203.87	$3.66M	300,141	SEC↗
Kelsey Stephen Michael	See Remarks	S Sale	2026-09-11	2026-09-15	18,869	$203.06	$3.83M	318,090	SEC↗
Kelsey Stephen Michael	See Remarks	S Sale	2026-09-11	2026-09-15	21,447	$201.75	$4.33M	336,959	SEC↗
Kelsey Stephen Michael	See Remarks	S Sale	2026-09-11	2026-09-15	13,368	$200.78	$2.68M	358,406	SEC↗
Kelsey Stephen Michael	See Remarks	S Sale	2026-09-11	2026-09-15	11,833	$200.11	$2.37M	371,774	SEC↗
Kelsey Stephen Michael	See Remarks	S Sale	2026-09-11	2026-09-15	800	$198.55	$158.8K	383,607	SEC↗
Kelsey Stephen Michael	See Remarks	M Exercise	2026-09-11	2026-09-15	40,031	$40.74	$1.63M	384,407	SEC↗
Kelsey Stephen Michael	See Remarks	M Exercise	2026-09-11	2026-09-15	52,500	$42.45	$2.23M	344,376	SEC↗
Mancini Anthony	See Remarks	M Exercise deriv	2026-09-10	2026-09-14	9,363	—	$0	96,746	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-09-10	2026-09-14	5,530	$204.14	$1.13M	47,789	SEC↗
Mancini Anthony	See Remarks	M Exercise	2026-09-10	2026-09-14	9,363	$33.62	$314.8K	59,338	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-09-10	2026-09-14	6,019	$203.28	$1.22M	53,319	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-09-10	2026-09-14	300	$207.17	$62.2K	43,890	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-09-10	2026-09-14	1,179	$206.10	$243.0K	44,190	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-09-10	2026-09-14	2,420	$205.05	$496.2K	45,369	SEC↗
Mancini Anthony	See Remarks	M Exercise deriv	2026-09-10	2026-09-14	9,363	—	$0	96,746	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-09-10	2026-09-14	300	$207.17	$62.2K	43,890	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-09-10	2026-09-14	1,179	$206.10	$243.0K	44,190	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-09-10	2026-09-14	2,420	$205.05	$496.2K	45,369	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-09-10	2026-09-14	5,530	$204.14	$1.13M	47,789	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-09-10	2026-09-14	6,019	$203.28	$1.22M	53,319	SEC↗
Mancini Anthony	See Remarks	M Exercise	2026-09-10	2026-09-14	9,363	$33.62	$314.8K	59,338	SEC↗
Kim Lorence H.	Director	S Sale	2026-09-08	2026-09-10	2,853	$209.56	$597.9K	8,945	SEC↗
Kim Lorence H.	Director	S Sale	2026-09-08	2026-09-10	3,844	$211.36	$812.5K	371	SEC↗
Kim Lorence H.	Director	S Sale	2026-09-08	2026-09-10	4,730	$210.50	$995.7K	4,215	SEC↗
Kim Lorence H.	Director	S Sale	2026-09-08	2026-09-10	371	$212.27	$78.8K	0	SEC↗
Kim Lorence H.	Director	S Sale	2026-09-08	2026-09-10	3,587	$208.55	$748.1K	11,798	SEC↗
Kim Lorence H.	Director	S Sale	2026-09-08	2026-09-10	999	$207.33	$207.1K	15,385	SEC↗
Kim Lorence H.	Director	S Sale	2026-09-08	2026-09-10	706	$206.60	$145.9K	16,384	SEC↗
Kim Lorence H.	Director	S Sale	2026-09-08	2026-09-10	371	$212.27	$78.8K	0	SEC↗
Kim Lorence H.	Director	S Sale	2026-09-08	2026-09-10	3,844	$211.36	$812.5K	371	SEC↗
Kim Lorence H.	Director	S Sale	2026-09-08	2026-09-10	4,730	$210.50	$995.7K	4,215	SEC↗
Kim Lorence H.	Director	S Sale	2026-09-08	2026-09-10	2,853	$209.56	$597.9K	8,945	SEC↗
Kim Lorence H.	Director	S Sale	2026-09-08	2026-09-10	3,587	$208.55	$748.1K	11,798	SEC↗
Kim Lorence H.	Director	S Sale	2026-09-08	2026-09-10	999	$207.33	$207.1K	15,385	SEC↗
Kim Lorence H.	Director	S Sale	2026-09-08	2026-09-10	706	$206.60	$145.9K	16,384	SEC↗
Kim Lorence H.	Director	S Sale	2026-08-31	2026-09-02	2,128	$205.19	$436.6K	17,715	SEC↗
Kim Lorence H.	Director	S Sale	2026-08-31	2026-09-02	12,919	$202.48	$2.62M	53,274	SEC↗
Kim Lorence H.	Director	S Sale	2026-08-31	2026-09-02	7,271	$204.35	$1.49M	19,843	SEC↗
Kim Lorence H.	Director	S Sale	2026-08-31	2026-09-02	26,160	$203.55	$5.32M	27,114	SEC↗
Kim Lorence H.	Director	S Sale	2026-08-31	2026-09-02	6,597	$201.47	$1.33M	66,193	SEC↗
Kim Lorence H.	Director	S Sale	2026-08-31	2026-09-02	300	$200.56	$60.2K	72,790	SEC↗
Kim Lorence H.	Director	S Sale	2026-08-31	2026-09-02	625	$206.15	$128.8K	17,090	SEC↗
Kim Lorence H.	Director	S Sale	2026-08-31	2026-09-02	625	$206.15	$128.8K	17,090	SEC↗
Kim Lorence H.	Director	S Sale	2026-08-31	2026-09-02	2,128	$205.19	$436.6K	17,715	SEC↗
Kim Lorence H.	Director	S Sale	2026-08-31	2026-09-02	7,271	$204.35	$1.49M	19,843	SEC↗
Kim Lorence H.	Director	S Sale	2026-08-31	2026-09-02	26,160	$203.55	$5.32M	27,114	SEC↗
Kim Lorence H.	Director	S Sale	2026-08-31	2026-09-02	12,919	$202.48	$2.62M	53,274	SEC↗
Kim Lorence H.	Director	S Sale	2026-08-31	2026-09-02	6,597	$201.47	$1.33M	66,193	SEC↗
Kim Lorence H.	Director	S Sale	2026-08-31	2026-09-02	300	$200.56	$60.2K	72,790	SEC↗
GOLDSMITH MARK A	See Remarks	M Exercise deriv	2026-08-21	2026-08-25	80,000	—	$0	344,085	SEC↗
Cislini Jeff	General Counsel	M Exercise deriv	2026-08-21	2026-08-25	26,600	—	$0	3,500	SEC↗
Cislini Jeff	General Counsel	M Exercise deriv	2026-08-21	2026-08-25	29,680	—	$0	0	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-08-21	2026-08-25	136	$210.40	$28.6K	61,796	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-08-21	2026-08-25	1,351	$209.28	$282.7K	61,932	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-08-21	2026-08-25	951	$208.36	$198.2K	63,283	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-08-21	2026-08-25	190	$207.25	$39.4K	64,234	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-08-21	2026-08-25	3,621	$212.08	$767.9K	267,330	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-08-21	2026-08-25	6,583	$211.33	$1.39M	270,951	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-08-21	2026-08-25	3,813	$210.25	$801.7K	277,534	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-08-21	2026-08-25	35,938	$209.26	$7.52M	281,347	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-08-21	2026-08-25	24,917	$208.37	$5.19M	317,285	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-08-21	2026-08-25	5,128	$207.23	$1.06M	342,202	SEC↗
GOLDSMITH MARK A	See Remarks	M Exercise	2026-08-21	2026-08-25	80,000	$4.73	$378.4K	347,330	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-08-21	2026-08-25	126	$212.06	$26.7K	61,424	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-08-21	2026-08-25	127	$212.06	$26.9K	61,424	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-08-21	2026-08-25	177	$207.25	$36.7K	64,247	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-08-21	2026-08-25	937	$208.36	$195.2K	63,310	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-08-21	2026-08-25	1,405	$209.27	$294.0K	61,905	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-08-21	2026-08-25	126	$210.40	$26.5K	61,779	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-08-21	2026-08-25	229	$211.46	$48.4K	61,550	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-08-21	2026-08-25	245	$211.47	$51.8K	61,551	SEC↗
Cislini Jeff	General Counsel	M Exercise	2026-08-21	2026-08-25	26,600	$21.61	$574.8K	112,801	SEC↗
Cislini Jeff	General Counsel	S Sale	2026-08-21	2026-08-25	17,323	$208.37	$3.61M	92,078	SEC↗
Cislini Jeff	General Counsel	S Sale	2026-08-21	2026-08-25	25,817	$209.25	$5.40M	66,261	SEC↗
Cislini Jeff	General Counsel	S Sale	2026-08-21	2026-08-25	3,400	$207.24	$704.6K	109,401	SEC↗
Cislini Jeff	General Counsel	S Sale	2026-08-21	2026-08-25	4,500	$211.34	$951.0K	59,221	SEC↗
Cislini Jeff	General Counsel	S Sale	2026-08-21	2026-08-25	3,314	$212.06	$702.8K	55,907	SEC↗
Cislini Jeff	General Counsel	S Sale	2026-08-21	2026-08-25	2,540	$210.26	$534.1K	63,721	SEC↗
Cislini Jeff	General Counsel	M Exercise	2026-08-21	2026-08-25	29,680	$18.56	$550.9K	86,201	SEC↗
GOLDSMITH MARK A	See Remarks, Director	M Exercise deriv	2026-08-21	2026-08-25	80,000	—	$0	344,085	SEC↗
GOLDSMITH MARK A	See Remarks, Director	S Sale	2026-08-21	2026-08-25	126	$212.06	$26.7K	61,424	SEC↗
GOLDSMITH MARK A	See Remarks, Director	S Sale	2026-08-21	2026-08-25	229	$211.46	$48.4K	61,550	SEC↗
GOLDSMITH MARK A	See Remarks, Director	S Sale	2026-08-21	2026-08-25	126	$210.40	$26.5K	61,779	SEC↗
GOLDSMITH MARK A	See Remarks, Director	S Sale	2026-08-21	2026-08-25	1,405	$209.27	$294.0K	61,905	SEC↗
GOLDSMITH MARK A	See Remarks, Director	S Sale	2026-08-21	2026-08-25	937	$208.36	$195.2K	63,310	SEC↗
GOLDSMITH MARK A	See Remarks, Director	S Sale	2026-08-21	2026-08-25	177	$207.25	$36.7K	64,247	SEC↗
GOLDSMITH MARK A	See Remarks, Director	S Sale	2026-08-21	2026-08-25	127	$212.06	$26.9K	61,424	SEC↗
GOLDSMITH MARK A	See Remarks, Director	S Sale	2026-08-21	2026-08-25	245	$211.47	$51.8K	61,551	SEC↗
GOLDSMITH MARK A	See Remarks, Director	S Sale	2026-08-21	2026-08-25	136	$210.40	$28.6K	61,796	SEC↗
GOLDSMITH MARK A	See Remarks, Director	S Sale	2026-08-21	2026-08-25	1,351	$209.28	$282.7K	61,932	SEC↗
GOLDSMITH MARK A	See Remarks, Director	S Sale	2026-08-21	2026-08-25	951	$208.36	$198.2K	63,283	SEC↗
GOLDSMITH MARK A	See Remarks, Director	S Sale	2026-08-21	2026-08-25	190	$207.25	$39.4K	64,234	SEC↗
GOLDSMITH MARK A	See Remarks, Director	S Sale	2026-08-21	2026-08-25	3,621	$212.08	$767.9K	267,330	SEC↗
GOLDSMITH MARK A	See Remarks, Director	S Sale	2026-08-21	2026-08-25	6,583	$211.33	$1.39M	270,951	SEC↗
GOLDSMITH MARK A	See Remarks, Director	S Sale	2026-08-21	2026-08-25	3,813	$210.25	$801.7K	277,534	SEC↗
GOLDSMITH MARK A	See Remarks, Director	S Sale	2026-08-21	2026-08-25	35,938	$209.26	$7.52M	281,347	SEC↗
GOLDSMITH MARK A	See Remarks, Director	S Sale	2026-08-21	2026-08-25	24,917	$208.37	$5.19M	317,285	SEC↗
GOLDSMITH MARK A	See Remarks, Director	S Sale	2026-08-21	2026-08-25	5,128	$207.23	$1.06M	342,202	SEC↗
GOLDSMITH MARK A	See Remarks, Director	M Exercise	2026-08-21	2026-08-25	80,000	$4.73	$378.4K	347,330	SEC↗
Cislini Jeff	General Counsel	M Exercise deriv	2026-08-21	2026-08-25	26,600	—	$0	3,500	SEC↗
Cislini Jeff	General Counsel	M Exercise deriv	2026-08-21	2026-08-25	29,680	—	$0	0	SEC↗
Cislini Jeff	General Counsel	S Sale	2026-08-21	2026-08-25	3,314	$212.06	$702.8K	55,907	SEC↗
Cislini Jeff	General Counsel	S Sale	2026-08-21	2026-08-25	4,500	$211.34	$951.0K	59,221	SEC↗
Cislini Jeff	General Counsel	S Sale	2026-08-21	2026-08-25	2,540	$210.26	$534.1K	63,721	SEC↗
Cislini Jeff	General Counsel	S Sale	2026-08-21	2026-08-25	25,817	$209.25	$5.40M	66,261	SEC↗
Cislini Jeff	General Counsel	S Sale	2026-08-21	2026-08-25	17,323	$208.37	$3.61M	92,078	SEC↗
Cislini Jeff	General Counsel	S Sale	2026-08-21	2026-08-25	3,400	$207.24	$704.6K	109,401	SEC↗
Cislini Jeff	General Counsel	M Exercise	2026-08-21	2026-08-25	26,600	$21.61	$574.8K	112,801	SEC↗
Cislini Jeff	General Counsel	M Exercise	2026-08-21	2026-08-25	29,680	$18.56	$550.9K	86,201	SEC↗
Patel Sushil	Director	M Exercise deriv	2026-06-29	2026-07-01	2,955	—	$0	13,000	SEC↗
Patel Sushil	Director	S Sale	2026-06-29	2026-07-01	858	$186.92	$160.4K	24,078	SEC↗
Patel Sushil	Director	M Exercise	2026-06-29	2026-07-01	2,955	$37.54	$110.9K	27,236	SEC↗
Patel Sushil	Director	S Sale	2026-06-29	2026-07-01	541	$191.87	$103.8K	22,537	SEC↗
Patel Sushil	Director	S Sale	2026-06-29	2026-07-01	600	$190.55	$114.3K	23,078	SEC↗
Patel Sushil	Director	S Sale	2026-06-29	2026-07-01	100	$188.57	$18.9K	23,678	SEC↗
Patel Sushil	Director	S Sale	2026-06-29	2026-07-01	300	$187.83	$56.3K	23,778	SEC↗
Patel Sushil	Director	S Sale	2026-06-29	2026-07-01	881	$192.61	$169.7K	21,656	SEC↗
Patel Sushil	Director	S Sale	2026-06-29	2026-07-01	1,100	$185.90	$204.5K	24,936	SEC↗
Patel Sushil	Director	S Sale	2026-06-29	2026-07-01	900	$184.59	$166.1K	26,036	SEC↗
Patel Sushil	Director	S Sale	2026-06-29	2026-07-01	300	$183.17	$55.0K	26,936	SEC↗
Anders Jack	Chief Financial Officer	M Exercise deriv	2026-06-24	2026-06-26	20,000	—	$0	20,600	SEC↗
Anders Jack	Chief Financial Officer	M Exercise	2026-06-24	2026-06-26	20,000	$18.56	$371.2K	143,269	SEC↗
Anders Jack	Chief Financial Officer	S Sale	2026-06-24	2026-06-26	300	$170.32	$51.1K	123,269	SEC↗
Anders Jack	Chief Financial Officer	S Sale	2026-06-24	2026-06-26	9,496	$168.20	$1.60M	129,220	SEC↗
Anders Jack	Chief Financial Officer	S Sale	2026-06-24	2026-06-26	4,553	$167.35	$761.9K	138,716	SEC↗
Anders Jack	Chief Financial Officer	S Sale	2026-06-24	2026-06-26	5,651	$169.24	$956.4K	123,569	SEC↗
Borellini Flavia	Director	A Award deriv	2026-06-18	2026-06-23	3,127	—	$0	3,127	SEC↗
Patel Sushil	Director	A Award deriv	2026-06-18	2026-06-23	3,127	—	$0	3,127	SEC↗
Clyburn Frank	Director	A Award deriv	2026-06-18	2026-06-23	3,127	—	$0	3,127	SEC↗
Horning Sandra	Director	A Award deriv	2026-06-18	2026-06-23	3,127	—	$0	3,127	SEC↗
ANDERSON ELIZABETH M	Director	A Award deriv	2026-06-18	2026-06-23	3,127	—	$0	3,127	SEC↗
Borisy Alexis	Director	A Award deriv	2026-06-18	2026-06-23	3,127	—	$0	3,127	SEC↗
Kim Lorence H.	Director	A Award deriv	2026-06-18	2026-06-23	3,127	—	$0	3,127	SEC↗
Borellini Flavia	Director	A Award	2026-06-18	2026-06-23	1,191	—	$0	26,215	SEC↗
Patel Sushil	Director	A Award	2026-06-18	2026-06-23	1,191	—	$0	24,281	SEC↗
Clyburn Frank	Director	A Award	2026-06-18	2026-06-23	1,191	—	$0	10,929	SEC↗
Horning Sandra	Director	A Award	2026-06-18	2026-06-23	1,191	—	$0	97,765	SEC↗
ANDERSON ELIZABETH M	Director	A Award	2026-06-18	2026-06-23	1,191	—	$0	9,406	SEC↗
Borisy Alexis	Director	A Award	2026-06-18	2026-06-23	1,191	—	$0	2,340,075	SEC↗
Kim Lorence H.	Director	A Award	2026-06-18	2026-06-23	1,191	—	$0	74,281	SEC↗
Horn Margaret A	Chief Operating Officer	M Exercise deriv	2026-06-17	2026-06-17	3,302	—	$0	71,750	SEC↗
Horn Margaret A	Chief Operating Officer	M Exercise deriv	2026-06-17	2026-06-17	573	—	$0	75,075	SEC↗
Horn Margaret A	Chief Operating Officer	M Exercise deriv	2026-06-17	2026-06-17	25,725	—	$0	114,275	SEC↗
Horn Margaret A	Chief Operating Officer	M Exercise	2026-06-17	2026-06-17	573	$40.74	$23.3K	155,220	SEC↗
Horn Margaret A	Chief Operating Officer	M Exercise	2026-06-17	2026-06-17	3,302	$29.80	$98.4K	158,522	SEC↗
Horn Margaret A	Chief Operating Officer	S Sale	2026-06-17	2026-06-17	29,600	$160.12	$4.74M	154,647	SEC↗
Horn Margaret A	Chief Operating Officer	M Exercise	2026-06-17	2026-06-17	25,725	$26.50	$681.7K	184,247	SEC↗
Kelsey Stephen Michael	See Remarks	S Sale	2026-06-16	2026-06-18	4,175	$156.12	$651.8K	291,876	SEC↗
Anders Jack	Chief Financial Officer	S Sale	2026-06-16	2026-06-18	2,722	$156.12	$425.0K	123,269	SEC↗
Cislini Jeff	General Counsel	S Sale	2026-06-16	2026-06-18	2,157	$156.12	$336.8K	56,521	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-06-16	2026-06-18	10,020	$156.12	$1.56M	267,330	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-06-16	2026-06-18	4,615	$156.12	$720.5K	49,975	SEC↗
Horn Margaret A	Chief Operating Officer	M Exercise deriv	2026-06-15	2026-06-17	44,854	—	$0	75,052	SEC↗
Horn Margaret A	Chief Operating Officer	M Exercise deriv	2026-06-15	2026-06-17	15,546	—	$0	75,648	SEC↗
Horn Margaret A	Chief Operating Officer	M Exercise	2026-06-15	2026-06-17	15,546	$40.74	$633.3K	173,768	SEC↗
Horn Margaret A	Chief Operating Officer	M Exercise	2026-06-15	2026-06-17	44,854	$29.80	$1.34M	218,622	SEC↗
Horn Margaret A	Chief Operating Officer	S Sale	2026-06-15	2026-06-17	60,400	$160.17	$9.67M	158,222	SEC↗
Horn Margaret A	Chief Operating Officer	M Exercise deriv	2026-06-11	2026-06-15	1,094	—	$0	0	SEC↗
Horn Margaret A	Chief Operating Officer	M Exercise deriv	2026-06-11	2026-06-15	8,906	—	$0	91,194	SEC↗
Horn Margaret A	Chief Operating Officer	S Sale	2026-06-11	2026-06-15	500	$147.27	$73.6K	164,822	SEC↗
Horn Margaret A	Chief Operating Officer	S Sale	2026-06-11	2026-06-15	200	$150.17	$30.0K	158,222	SEC↗
Horn Margaret A	Chief Operating Officer	S Sale	2026-06-11	2026-06-15	4,600	$149.64	$688.3K	158,422	SEC↗
Horn Margaret A	Chief Operating Officer	S Sale	2026-06-11	2026-06-15	1,800	$148.72	$267.7K	163,022	SEC↗
Horn Margaret A	Chief Operating Officer	S Sale	2026-06-11	2026-06-15	885	$145.15	$128.5K	166,022	SEC↗
Horn Margaret A	Chief Operating Officer	S Sale	2026-06-11	2026-06-15	700	$146.04	$102.2K	165,322	SEC↗
Horn Margaret A	Chief Operating Officer	S Sale	2026-06-11	2026-06-15	1,315	$144.28	$189.7K	166,907	SEC↗
Horn Margaret A	Chief Operating Officer	M Exercise	2026-06-11	2026-06-15	1,094	$42.45	$46.4K	159,316	SEC↗
Horn Margaret A	Chief Operating Officer	M Exercise	2026-06-11	2026-06-15	8,906	$40.74	$362.8K	168,222	SEC↗
Mancini Anthony	See Remarks	M Exercise deriv	2026-05-26	2026-05-28	3,121	—	$0	106,109	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-05-26	2026-05-28	421	$154.82	$65.2K	54,400	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-05-26	2026-05-28	2,000	$154.06	$308.1K	54,821	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-05-26	2026-05-28	700	$153.30	$107.3K	56,821	SEC↗
Mancini Anthony	See Remarks	M Exercise	2026-05-26	2026-05-28	3,121	$33.62	$104.9K	57,521	SEC↗
Mancini Anthony	See Remarks	M Exercise deriv	2026-04-27	2026-04-29	3,120	—	$0	109,230	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-04-27	2026-04-29	1,049	$132.88	$139.4K	54,800	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-04-27	2026-04-29	400	$134.34	$53.7K	54,400	SEC↗
Mancini Anthony	See Remarks	M Exercise	2026-04-27	2026-04-29	3,120	$33.62	$104.9K	57,520	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-04-27	2026-04-29	1,671	$131.66	$220.0K	55,849	SEC↗
GOLDSMITH MARK A	See Remarks	M Exercise deriv	2026-04-15	2026-04-17	96,756	—	$0	424,085	SEC↗
GOLDSMITH MARK A	See Remarks	M Exercise deriv	2026-04-15	2026-04-17	23,244	—	$0	24,464	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-04-15	2026-04-17	120,000	$150.09	$18.01M	276,698	SEC↗
GOLDSMITH MARK A	See Remarks	M Exercise	2026-04-15	2026-04-17	96,756	$4.73	$457.7K	396,698	SEC↗
GOLDSMITH MARK A	See Remarks	M Exercise	2026-04-15	2026-04-17	23,244	$4.09	$95.1K	299,942	SEC↗
Mancini Anthony	See Remarks	M Exercise deriv	2026-03-25	2026-03-26	37,450	—	$0	112,350	SEC↗
Mancini Anthony	See Remarks	M Exercise	2026-03-25	2026-03-26	37,450	$33.62	$1.26M	91,850	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-03-25	2026-03-26	1,800	$93.22	$167.8K	90,050	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-03-25	2026-03-26	3,128	$94.16	$294.5K	86,922	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-03-25	2026-03-26	21,086	$95.49	$2.01M	65,836	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-03-25	2026-03-26	11,036	$96.43	$1.06M	54,800	SEC↗
Mancini Anthony	See Remarks	S Sale	2026-03-25	2026-03-26	400	$97.21	$38.9K	54,400	SEC↗
Cislini Jeff	General Counsel	S Sale	2026-03-19	2026-03-19	1,163	$97.44	$113.3K	58,518	SEC↗
Wang Xiaolin	See Remarks	S Sale	2026-03-17	2026-03-19	2,010	$99.48	$200.0K	116,063	SEC↗
Cislini Jeff	General Counsel	S Sale	2026-03-17	2026-03-19	1,795	$99.48	$178.6K	59,681	SEC↗
Anders Jack	Chief Financial Officer	S Sale	2026-03-17	2026-03-19	2,753	$99.48	$273.9K	125,512	SEC↗
Horn Margaret A	Chief Operating Officer	S Sale	2026-03-17	2026-03-19	4,583	$99.48	$455.9K	157,570	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-03-17	2026-03-19	12,871	$99.48	$1.28M	276,698	SEC↗
Kelsey Stephen Michael	See Remarks	S Sale	2026-03-17	2026-03-19	4,302	$99.48	$428.0K	295,398	SEC↗
Wei Lin	Chief Medical Officer	S Sale	2026-03-17	2026-03-19	2,073	$99.48	$206.2K	101,366	SEC↗
ANDERSON ELIZABETH M	Director	G Gift	2026-03-04	2026-03-06	15,000	—	$0	8,215	SEC↗
ANDERSON ELIZABETH M	Director	G Gift	2026-03-04	2026-03-06	15,000	—	$0	15,000	SEC↗
GOLDSMITH MARK A	See Remarks	M Exercise deriv	2026-03-02	2026-03-03	30,000	—	$0	47,708	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-03-02	2026-03-03	851	$102.20	$87.0K	289,569	SEC↗
GOLDSMITH MARK A	See Remarks	M Exercise	2026-03-02	2026-03-03	30,000	$4.09	$122.7K	319,569	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-03-02	2026-03-03	700	$98.17	$68.7K	318,869	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-03-02	2026-03-03	3,500	$99.76	$349.2K	315,369	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-03-02	2026-03-03	200	$102.08	$20.4K	64,424	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-03-02	2026-03-03	2,100	$101.63	$213.4K	64,624	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-03-02	2026-03-03	600	$100.19	$60.1K	66,724	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-03-02	2026-03-03	100	$98.29	$9.8K	67,324	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-03-02	2026-03-03	800	$102.00	$81.6K	64,424	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-03-02	2026-03-03	1,700	$101.47	$172.5K	65,224	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-03-02	2026-03-03	400	$100.12	$40.0K	66,924	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-03-02	2026-03-03	100	$98.31	$9.8K	67,324	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-03-02	2026-03-03	21,329	$101.60	$2.17M	290,420	SEC↗
GOLDSMITH MARK A	See Remarks	S Sale	2026-03-02	2026-03-03	3,620	$100.73	$364.6K	311,749	SEC↗
Anders Jack	Chief Financial Officer	A Award deriv	2026-03-01	2026-03-03	45,400	—	$0	45,400	SEC↗
Cislini Jeff	General Counsel	A Award deriv	2026-03-01	2026-03-03	32,500	—	$0	32,500	SEC↗
Horn Margaret A	Chief Operating Officer	A Award deriv	2026-03-01	2026-03-03	47,600	—	$0	47,600	SEC↗
GOLDSMITH MARK A	See Remarks	A Award deriv	2026-03-01	2026-03-03	128,600	—	$0	128,600	SEC↗