Open-mkt buys · 90d
—
0 trades · 0 insiders
Open-mkt sales · 90d
—
0 trades · 0 insiders
Net · 90d
$0
Insiders on file
27
Daily buy vs sell · 90 days
No data yet.
Insiders
| Insider | Role | Trades | Bought | Sold | Last trade |
|---|---|---|---|---|---|
| Abraham William Tober | Director | 9 | $0 | $0 | 2025-10-07 |
| Nokes Rachael | See Remarks | 23 | $0 | $0 | 2025-10-07 |
| Baylor-Henry Minnie | Director | 13 | $0 | $0 | 2025-10-07 |
| Agger Mette Kirstine | Director, 10% Owner | 13 | $9.17M | $0 | 2025-10-07 |
| Bonstein Sara | Director | 9 | $0 | $0 | 2025-10-07 |
| Khattar Jack A. | Director | 14 | $19.6K | $0 | 2025-10-07 |
| Hudson Frederick M. | Director | 12 | $0 | $0 | 2025-10-07 |
| Tucker John H | President and CEO | 29 | $65.8K | $0 | 2025-10-07 |
| VEITINGER KLAUS R DR | Director | 12 | $0 | $0 | 2025-10-07 |
| SCHAEFFER LEONARD D | Director | 23 | $0 | $0 | 2025-10-07 |
| OrbiMed Capital GP VI LLC | 10% Owner | 2 | $2.00M | $0 | 2024-08-13 |
| ORBIMED ADVISORS LLC | 10% Owner | 6 | $27.67M | $0 | 2022-11-25 |
| DIEKMAN JOHN D | 10% Owner | 6 | $0 | $2.49M | 2022-10-10 |
| 5AM Partners IV, LLC | 10% Owner | 6 | $0 | $1.10M | 2022-09-07 |
| 5AM Opportunities I (GP), LLC | 10% Owner | 3 | $0 | $1.35M | 2022-04-11 |
| RA Capital Healthcare Fund LP | 10% Owner | 4 | $3.28M | $1.06M | 2021-03-15 |
| Freeman Mason | Director | 3 | $0 | $0 | 2020-06-09 |
| Coleman Dorothy | Director | 5 | $0 | $0 | 2020-06-09 |
| Schwab Andrew J. | 10% Owner | 1 | $5.00M | $0 | 2020-05-26 |
| Kolchinsky Peter | 10% Owner | 1 | $2.23M | $0 | 2020-02-14 |
| PARMAR KUSH | Director | 1 | $0 | $0 | 2018-06-19 |
| Ceesay Abraham | Chief Operating Officer | 1 | $0 | $0 | 2018-01-17 |
| Ignelzi Troy A. | Chief Financial Officer | 1 | $0 | $0 | 2018-01-17 |
| Sun Pharmaceutical Industries, Inc. | 10% Owner | 3 | $5.00M | $0 | 2017-11-21 |
| 5AM Co-Investors IV, L.P. | 10% Owner | 10 | $9.17M | $0 | 2017-11-21 |
| Lundbeckfond Invest A/S | 10% Owner | 5 | $9.17M | $0 | 2017-11-21 |
| SILVERSTEIN JONATHAN | Director | 2 | $0 | $0 | 2017-11-21 |
Trade history
| Insider | Role | Code | Trade | Filed | Shares | Price | Value | Owned after | |
|---|---|---|---|---|---|---|---|---|---|
| Khattar Jack A. | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 30,000 | — | $0 | 0 | SEC↗ |
| Khattar Jack A. | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 6,124 | — | $0 | 0 | SEC↗ |
| Khattar Jack A. | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 16,300 | — | $0 | 0 | SEC↗ |
| Khattar Jack A. | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 19,750 | — | $0 | 0 | SEC↗ |
| Agger Mette Kirstine | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 30,000 | — | $0 | 0 | SEC↗ |
| Agger Mette Kirstine | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 19,750 | — | $0 | 0 | SEC↗ |
| Bonstein Sara | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 19,750 | — | $0 | 0 | SEC↗ |
| Bonstein Sara | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 30,000 | — | $0 | 0 | SEC↗ |
| Bonstein Sara | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 16,300 | — | $0 | 0 | SEC↗ |
| Tucker John H | President and CEO | D To issuer deriv | 2025-10-07 | 2025-10-07 | 300,000 | — | $0 | 0 | SEC↗ |
| Tucker John H | President and CEO | D To issuer deriv | 2025-10-07 | 2025-10-07 | 84,500 | — | $0 | 0 | SEC↗ |
| Tucker John H | President and CEO | D To issuer deriv | 2025-10-07 | 2025-10-07 | 496,674 | — | $0 | 0 | SEC↗ |
| Tucker John H | President and CEO | D To issuer deriv | 2025-10-07 | 2025-10-07 | 249,000 | — | $0 | 0 | SEC↗ |
| Nokes Rachael | CFO and Treasurer | D To issuer deriv | 2025-10-07 | 2025-10-07 | 6,426 | — | $0 | 0 | SEC↗ |
| Nokes Rachael | CFO and Treasurer | D To issuer deriv | 2025-10-07 | 2025-10-07 | 132,670 | — | $0 | 0 | SEC↗ |
| Nokes Rachael | CFO and Treasurer | D To issuer deriv | 2025-10-07 | 2025-10-07 | 54,700 | — | $0 | 0 | SEC↗ |
| Nokes Rachael | CFO and Treasurer | D To issuer deriv | 2025-10-07 | 2025-10-07 | 13,850 | — | $0 | 0 | SEC↗ |
| Hudson Frederick M. | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 6,124 | — | $0 | 0 | SEC↗ |
| Hudson Frederick M. | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 16,300 | — | $0 | 0 | SEC↗ |
| Hudson Frederick M. | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 30,000 | — | $0 | 0 | SEC↗ |
| Hudson Frederick M. | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 19,750 | — | $0 | 0 | SEC↗ |
| Baylor-Henry Minnie | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 16,300 | — | $0 | 0 | SEC↗ |
| Baylor-Henry Minnie | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 12,248 | — | $0 | 0 | SEC↗ |
| Baylor-Henry Minnie | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 6,124 | — | $0 | 0 | SEC↗ |
| Baylor-Henry Minnie | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 19,750 | — | $0 | 0 | SEC↗ |
| Baylor-Henry Minnie | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 30,000 | — | $0 | 0 | SEC↗ |
| Abraham William Tober | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 30,000 | — | $0 | 0 | SEC↗ |
| Abraham William Tober | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 16,300 | — | $0 | 0 | SEC↗ |
| Abraham William Tober | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 19,750 | — | $0 | 0 | SEC↗ |
| VEITINGER KLAUS R DR | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 6,124 | — | $0 | 0 | SEC↗ |
| VEITINGER KLAUS R DR | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 30,000 | — | $0 | 0 | SEC↗ |
| VEITINGER KLAUS R DR | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 19,750 | — | $0 | 0 | SEC↗ |
| VEITINGER KLAUS R DR | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 16,300 | — | $0 | 0 | SEC↗ |
| SCHAEFFER LEONARD D | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 30,000 | — | $0 | 0 | SEC↗ |
| SCHAEFFER LEONARD D | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 19,750 | — | $0 | 0 | SEC↗ |
| SCHAEFFER LEONARD D | Director | D To issuer deriv | 2025-10-07 | 2025-10-07 | 16,300 | — | $0 | 0 | SEC↗ |
| Khattar Jack A. | Director | U Tender | 2025-10-07 | 2025-10-07 | 5,000 | — | $0 | 0 | SEC↗ |
| Tucker John H | President and CEO | D To issuer | 2025-10-07 | 2025-10-07 | 318,502 | — | $0 | 0 | SEC↗ |
| Tucker John H | President and CEO | U Tender | 2025-10-07 | 2025-10-07 | 122,345 | — | $0 | 318,502 | SEC↗ |
| Nokes Rachael | CFO and Treasurer | U Tender | 2025-10-07 | 2025-10-07 | 30,386 | — | $0 | 125,675 | SEC↗ |
| Nokes Rachael | CFO and Treasurer | D To issuer | 2025-10-07 | 2025-10-07 | 125,675 | — | $0 | 0 | SEC↗ |
| SCHAEFFER LEONARD D | Director | U Tender | 2025-10-07 | 2025-10-07 | 68,796 | — | $0 | 0 | SEC↗ |
| SCHAEFFER LEONARD D | Director | U Tender | 2025-10-07 | 2025-10-07 | 43,104 | — | $0 | 0 | SEC↗ |
| SCHAEFFER LEONARD D | Director | A Award deriv | 2025-06-03 | 2025-06-05 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Abraham William Tober | Director | A Award deriv | 2025-06-03 | 2025-06-05 | 30,000 | — | $0 | 30,000 | SEC↗ |
| VEITINGER KLAUS R DR | Director | A Award deriv | 2025-06-03 | 2025-06-05 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Khattar Jack A. | Director | A Award deriv | 2025-06-03 | 2025-06-05 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Hudson Frederick M. | Director | A Award deriv | 2025-06-03 | 2025-06-05 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Bonstein Sara | Director | A Award deriv | 2025-06-03 | 2025-06-05 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Baylor-Henry Minnie | Director | A Award deriv | 2025-06-03 | 2025-06-05 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Agger Mette Kirstine | Director | A Award deriv | 2025-06-03 | 2025-06-05 | 30,000 | — | $0 | 30,000 | SEC↗ |
| Nokes Rachael | CFO and Treasurer | A Award deriv | 2025-02-11 | 2025-02-12 | 132,670 | — | $0 | 132,670 | SEC↗ |
| Tucker John H | President and CEO | A Award deriv | 2025-02-11 | 2025-02-12 | 300,000 | — | $0 | 300,000 | SEC↗ |
| Nokes Rachael | CFO and Treasurer | A Award | 2025-02-11 | 2025-02-12 | 88,445 | — | $0 | 156,061 | SEC↗ |
| Tucker John H | President and CEO | A Award | 2025-02-11 | 2025-02-12 | 200,000 | — | $0 | 440,847 | SEC↗ |
| Nokes Rachael | CFO and Treasurer | F Tax w/h | 2025-01-03 | 2025-01-07 | 5,235 | $3.56 | $18.6K | 67,616 | SEC↗ |
| Tucker John H | President and CEO | F Tax w/h | 2025-01-03 | 2025-01-07 | 13,360 | $3.56 | $47.6K | 240,847 | SEC↗ |
| SCHAEFFER LEONARD D | Director | M Exercise deriv | 2024-08-26 | 2024-08-28 | 5,223 | — | $0 | 0 | SEC↗ |
| SCHAEFFER LEONARD D | Director | M Exercise deriv | 2024-08-26 | 2024-08-28 | 6,124 | — | $0 | 0 | SEC↗ |
| SCHAEFFER LEONARD D | Director | M Exercise | 2024-08-26 | 2024-08-28 | 6,124 | $3.37 | $20.6K | 54,451 | SEC↗ |
| SCHAEFFER LEONARD D | Director | M Exercise | 2024-08-26 | 2024-08-28 | 5,223 | $1.66 | $8.7K | 48,327 | SEC↗ |
| OrbiMed Capital GP VI LLC | 10% Owner | P Buy | 2024-08-13 | 2024-08-15 | 478,342 | $4.00 | $1.91M | 5,806,670 | SEC↗ |
| OrbiMed Capital GP VI LLC | 10% Owner | P Buy | 2024-08-13 | 2024-08-15 | 21,658 | $4.00 | $86.6K | 252,858 | SEC↗ |
| Nokes Rachael | CFO and Treasurer | M Exercise deriv | 2024-08-06 | 2024-08-08 | 10,445 | — | $0 | 0 | SEC↗ |
| Nokes Rachael | CFO and Treasurer | M Exercise | 2024-08-06 | 2024-08-08 | 10,445 | — | $0 | 72,851 | SEC↗ |
| Nokes Rachael | CFO and Treasurer | M Exercise | 2024-08-06 | 2024-08-28 | 10,445 | $1.66 | $17.3K | 72,851 | SEC↗ |
| Bonstein Sara | Director | A Award deriv | 2024-06-11 | 2024-06-13 | 19,750 | — | $0 | 19,750 | SEC↗ |
| Baylor-Henry Minnie | Director | A Award deriv | 2024-06-11 | 2024-06-13 | 19,750 | — | $0 | 19,750 | SEC↗ |
| VEITINGER KLAUS R DR | Director | A Award deriv | 2024-06-11 | 2024-06-13 | 19,750 | — | $0 | 19,750 | SEC↗ |
| Abraham William Tober | Director | A Award deriv | 2024-06-11 | 2024-06-13 | 19,750 | — | $0 | 19,750 | SEC↗ |
| Khattar Jack A. | Director | A Award deriv | 2024-06-11 | 2024-06-13 | 19,750 | — | $0 | 19,750 | SEC↗ |
| Hudson Frederick M. | Director | A Award deriv | 2024-06-11 | 2024-06-13 | 19,750 | — | $0 | 19,750 | SEC↗ |
| Agger Mette Kirstine | Director | A Award deriv | 2024-06-11 | 2024-06-13 | 19,750 | — | $0 | 19,750 | SEC↗ |
| SCHAEFFER LEONARD D | Director | A Award deriv | 2024-06-11 | 2024-06-13 | 19,750 | — | $0 | 19,750 | SEC↗ |
| Tucker John H | President and CEO | A Award deriv | 2024-03-29 | 2024-04-02 | 56,025 | — | $0 | 56,025 | SEC↗ |
| Tucker John H | President and CEO | A Award deriv | 2024-01-18 | 2024-01-22 | 170,340 | — | $0 | 170,340 | SEC↗ |
| Nokes Rachael | CFO and Treasurer | A Award deriv | 2024-01-18 | 2024-01-22 | 62,755 | — | $0 | 62,755 | SEC↗ |
| Tucker John H | President and CEO | A Award | 2024-01-18 | 2024-01-22 | 113,560 | — | $0 | 254,207 | SEC↗ |
| Nokes Rachael | CFO and Treasurer | A Award | 2024-01-18 | 2024-01-22 | 41,840 | — | $0 | 62,406 | SEC↗ |
| Tucker John H | President and CEO | F Tax w/h | 2024-01-02 | 2024-01-03 | 4,942 | $6.39 | $31.6K | 140,647 | SEC↗ |
| Nokes Rachael | CFO and Treasurer | F Tax w/h | 2024-01-02 | 2024-01-03 | 1,027 | $6.39 | $6.6K | 20,566 | SEC↗ |
| SCHAEFFER LEONARD D | Director | A Award deriv | 2023-06-06 | 2023-06-08 | 17,300 | — | $0 | 17,300 | SEC↗ |
| Bonstein Sara | Director | A Award deriv | 2023-06-06 | 2023-06-08 | 17,300 | — | $0 | 17,300 | SEC↗ |
| Khattar Jack A. | Director | A Award deriv | 2023-06-06 | 2023-06-08 | 17,300 | — | $0 | 17,300 | SEC↗ |
| Hudson Frederick M. | Director | A Award deriv | 2023-06-06 | 2023-06-08 | 17,300 | — | $0 | 17,300 | SEC↗ |
| Abraham William Tober | Director | A Award deriv | 2023-06-06 | 2023-06-08 | 17,300 | — | $0 | 17,300 | SEC↗ |
| VEITINGER KLAUS R DR | Director | A Award deriv | 2023-06-06 | 2023-06-08 | 17,300 | — | $0 | 17,300 | SEC↗ |
| Agger Mette Kirstine | Director | A Award deriv | 2023-06-06 | 2023-06-08 | 17,300 | — | $0 | 17,300 | SEC↗ |
| Baylor-Henry Minnie | Director | A Award deriv | 2023-06-06 | 2023-06-08 | 17,300 | — | $0 | 17,300 | SEC↗ |
| Nokes Rachael | See Remarks | A Award deriv | 2023-01-19 | 2023-01-23 | 17,550 | — | $0 | 17,550 | SEC↗ |
| Tucker John H | President and CEO | A Award deriv | 2023-01-19 | 2023-01-23 | 100,000 | — | $0 | 100,000 | SEC↗ |
| Nokes Rachael | See Remarks | A Award | 2023-01-19 | 2023-01-23 | 11,700 | $6.14 | $71.8K | 21,593 | SEC↗ |
| Tucker John H | President and CEO | A Award | 2023-01-19 | 2023-01-23 | 66,665 | $6.14 | $409.3K | 145,589 | SEC↗ |
| Nokes Rachael | See Remarks | A Award deriv | 2022-12-15 | 2022-12-19 | 85,750 | — | $0 | 85,750 | SEC↗ |
| ORBIMED ADVISORS LLC | 10% Owner | P Buy | 2022-11-25 | 2022-11-29 | 762,380 | $5.25 | $4.00M | 5,328,328 | SEC↗ |
| DIEKMAN JOHN D | 10% Owner | S Sale | 2022-10-10 | 2022-10-11 | 19,017 | $4.09 | $77.8K | 92,983 | SEC↗ |
| DIEKMAN JOHN D | 10% Owner | S Sale | 2022-10-10 | 2022-10-11 | 87,036 | $4.09 | $356.0K | 410,268 | SEC↗ |
| DIEKMAN JOHN D | 10% Owner | S Sale | 2022-10-10 | 2022-10-11 | 456,413 | $4.09 | $1.87M | 2,231,601 | SEC↗ |
| Tucker John H | President and CEO | M Exercise deriv | 2022-10-07 | 2022-10-11 | 42,250 | — | $0 | 0 | SEC↗ |
| Tucker John H | President and CEO | A Award deriv | 2022-10-07 | 2022-10-11 | 42,250 | — | $0 | 42,250 | SEC↗ |
| Tucker John H | President and CEO | M Exercise | 2022-10-07 | 2022-10-11 | 42,250 | — | $0 | 89,212 | SEC↗ |
| Tucker John H | President and CEO | F Tax w/h | 2022-10-07 | 2022-10-11 | 10,288 | $4.98 | $51.2K | 78,924 | SEC↗ |
| DIEKMAN JOHN D | 10% Owner | S Sale | 2022-10-06 | 2022-10-11 | 30,457 | $5.02 | $152.9K | 2,688,014 | SEC↗ |
| DIEKMAN JOHN D | 10% Owner | S Sale | 2022-10-06 | 2022-10-11 | 1,269 | $5.02 | $6.4K | 112,000 | SEC↗ |
| DIEKMAN JOHN D | 10% Owner | S Sale | 2022-10-06 | 2022-10-11 | 5,808 | $5.02 | $29.2K | 497,304 | SEC↗ |
| 5AM Partners IV, LLC | 10% Owner | S Sale | 2022-09-07 | 2022-09-08 | 6,793 | $4.75 | $32.3K | 113,269 | SEC↗ |
| 5AM Partners IV, LLC | 10% Owner | S Sale | 2022-09-07 | 2022-09-08 | 163,034 | $4.75 | $774.4K | 2,718,471 | SEC↗ |
| 5AM Partners IV, LLC | 10% Owner | S Sale | 2022-09-07 | 2022-09-08 | 30,173 | $4.75 | $143.3K | 503,112 | SEC↗ |
| 5AM Partners IV, LLC | 10% Owner | S Sale | 2022-09-06 | 2022-09-08 | 4,016 | $5.52 | $22.2K | 533,285 | SEC↗ |
| 5AM Partners IV, LLC | 10% Owner | S Sale | 2022-09-06 | 2022-09-08 | 21,702 | $5.52 | $119.8K | 2,881,505 | SEC↗ |
| 5AM Partners IV, LLC | 10% Owner | S Sale | 2022-09-06 | 2022-09-08 | 904 | $5.52 | $5.0K | 120,062 | SEC↗ |
| SCHAEFFER LEONARD D | Director | A Award deriv | 2022-06-14 | 2022-06-15 | 16,300 | — | $0 | 16,300 | SEC↗ |
| Baylor-Henry Minnie | Director | A Award deriv | 2022-06-14 | 2022-06-15 | 16,300 | — | $0 | 16,300 | SEC↗ |
| Abraham William Tober | Director | A Award deriv | 2022-06-14 | 2022-06-15 | 16,300 | — | $0 | 16,300 | SEC↗ |
| Khattar Jack A. | Director | A Award deriv | 2022-06-14 | 2022-06-15 | 16,300 | — | $0 | 16,300 | SEC↗ |
| VEITINGER KLAUS R DR | Director | A Award deriv | 2022-06-14 | 2022-06-15 | 16,300 | — | $0 | 16,300 | SEC↗ |
| Hudson Frederick M. | Director | A Award deriv | 2022-06-14 | 2022-06-15 | 16,300 | — | $0 | 16,300 | SEC↗ |
| Bonstein Sara | Director | A Award deriv | 2022-06-14 | 2022-06-15 | 16,300 | — | $0 | 16,300 | SEC↗ |
| 5AM Opportunities I (GP), LLC | 10% Owner | S Sale | 2022-04-11 | 2022-04-13 | 40,733 | $5.00 | $203.7K | 537,301 | SEC↗ |
| 5AM Opportunities I (GP), LLC | 10% Owner | S Sale | 2022-04-11 | 2022-04-13 | 220,096 | $5.00 | $1.10M | 2,903,207 | SEC↗ |
| 5AM Opportunities I (GP), LLC | 10% Owner | S Sale | 2022-04-11 | 2022-04-13 | 9,171 | $5.00 | $45.9K | 120,966 | SEC↗ |
| Tucker John H | President and CEO | A Award deriv | 2022-01-31 | 2022-02-01 | 249,000 | — | $0 | 249,000 | SEC↗ |
| Nokes Rachael | See Remarks | A Award deriv | 2022-01-31 | 2022-02-01 | 54,700 | — | $0 | 54,700 | SEC↗ |
| Tucker John H | President and CEO | P Buy | 2021-12-03 | 2021-12-06 | 10,000 | $3.96 | $39.6K | 46,962 | SEC↗ |
| Khattar Jack A. | Director | P Buy | 2021-12-03 | 2021-12-06 | 5,000 | $3.91 | $19.6K | 5,000 | SEC↗ |
| Abraham William Tober | Director | A Award deriv | 2021-06-08 | 2021-06-10 | 16,300 | — | $0 | 16,300 | SEC↗ |
| Hudson Frederick M. | Director | A Award deriv | 2021-06-08 | 2021-06-10 | 16,300 | — | $0 | 16,300 | SEC↗ |
| Bonstein Sara | Director | A Award deriv | 2021-06-08 | 2021-06-10 | 16,300 | — | $0 | 16,300 | SEC↗ |
| VEITINGER KLAUS R DR | Director | A Award deriv | 2021-06-08 | 2021-06-10 | 16,300 | — | $0 | 16,300 | SEC↗ |
| SCHAEFFER LEONARD D | Director | A Award deriv | 2021-06-08 | 2021-06-10 | 16,300 | — | $0 | 16,300 | SEC↗ |
| Baylor-Henry Minnie | Director | A Award deriv | 2021-06-08 | 2021-06-10 | 16,300 | — | $0 | 16,300 | SEC↗ |
| Khattar Jack A. | Director | A Award deriv | 2021-06-08 | 2021-06-10 | 16,300 | — | $0 | 16,300 | SEC↗ |
| RA Capital Healthcare Fund LP | 10% Owner | S Sale | 2021-03-15 | 2021-03-16 | 110,588 | $7.03 | $777.4K | 2,727,446 | SEC↗ |
| RA Capital Healthcare Fund LP | 10% Owner | S Sale | 2021-03-12 | 2021-03-16 | 39,469 | $7.22 | $285.0K | 2,838,034 | SEC↗ |
| Nokes Rachael | See Remarks | F Tax w/h | 2021-02-25 | 2023-01-23 | 1,976 | $7.27 | $14.4K | 9,893 | SEC↗ |
| Abraham William Tober | Director | A Award deriv | 2021-02-16 | 2021-02-17 | 32,600 | — | $0 | 32,600 | SEC↗ |
| Nokes Rachael | See Remarks | A Award deriv | 2021-01-25 | 2021-01-27 | 49,200 | — | $0 | 49,200 | SEC↗ |
| Tucker John H | President and CEO | A Award deriv | 2021-01-25 | 2021-01-27 | 112,050 | — | $0 | 112,050 | SEC↗ |
| Bonstein Sara | Director | A Award deriv | 2020-07-08 | 2020-07-13 | 12,248 | — | $0 | 12,248 | SEC↗ |
| Tucker John H | President and CEO | A Award deriv | 2020-06-30 | 2020-07-02 | 42,250 | — | $0 | 42,250 | SEC↗ |
| Tucker John H | President and CEO | M Exercise deriv | 2020-06-30 | 2020-07-02 | 42,250 | — | $0 | 0 | SEC↗ |
| Tucker John H | President and CEO | M Exercise | 2020-06-30 | 2020-07-02 | 42,250 | — | $0 | 47,250 | SEC↗ |
| Tucker John H | President and CEO | F Tax w/h | 2020-06-30 | 2020-07-02 | 10,288 | $7.36 | $75.7K | 36,962 | SEC↗ |
| SCHAEFFER LEONARD D | Director | A Award deriv | 2020-06-09 | 2020-06-11 | 6,124 | — | $0 | 6,124 | SEC↗ |
| Freeman Mason | Director | A Award deriv | 2020-06-09 | 2020-06-11 | 6,124 | — | $0 | 6,124 | SEC↗ |
| Khattar Jack A. | Director | A Award deriv | 2020-06-09 | 2020-06-11 | 6,124 | — | $0 | 6,124 | SEC↗ |
| Baylor-Henry Minnie | Director | A Award deriv | 2020-06-09 | 2020-06-11 | 6,124 | — | $0 | 6,124 | SEC↗ |
| VEITINGER KLAUS R DR | Director | A Award deriv | 2020-06-09 | 2020-06-11 | 6,124 | — | $0 | 6,124 | SEC↗ |
| Hudson Frederick M. | Director | A Award deriv | 2020-06-09 | 2020-06-11 | 6,124 | — | $0 | 6,124 | SEC↗ |
| Agger Mette Kirstine | Director | A Award deriv | 2020-06-09 | 2020-06-11 | 6,124 | — | $0 | 6,124 | SEC↗ |
| Coleman Dorothy | Director | A Award deriv | 2020-06-09 | 2020-06-11 | 6,124 | — | $0 | 6,124 | SEC↗ |
| Schwab Andrew J. | 10% Owner | P Buy | 2020-05-26 | 2020-05-28 | 578,034 | $8.65 | $5.00M | 578,034 | SEC↗ |
| ORBIMED ADVISORS LLC | 10% Owner | P Buy | 2020-05-21 | 2020-05-26 | 231,200 | $8.65 | $2.00M | 231,200 | SEC↗ |
| ORBIMED ADVISORS LLC | 10% Owner | P Buy | 2020-05-21 | 2020-05-26 | 1,156,083 | $8.65 | $10.00M | 4,565,948 | SEC↗ |
| Nokes Rachael | See Remarks | F Tax w/h | 2020-02-25 | 2023-01-23 | 1,981 | $10.09 | $20.0K | 11,869 | SEC↗ |
| Kolchinsky Peter | 10% Owner | P Buy | 2020-02-14 | 2020-02-19 | 271,993 | $8.20 | $2.23M | 3,247,005 | SEC↗ |
| RA Capital Healthcare Fund LP | 10% Owner | P Buy | 2020-02-14 | 2020-02-21 | 271,993 | $8.20 | $2.23M | 3,518,998 | SEC↗ |
| Nokes Rachael | See Remarks | A Award deriv | 2020-01-10 | 2020-01-14 | 44,500 | — | $0 | 44,500 | SEC↗ |
| Tucker John H | President and CEO | A Award deriv | 2020-01-10 | 2020-01-14 | 127,500 | — | $0 | 127,500 | SEC↗ |
| Tucker John H | President and CEO | P Buy | 2019-12-13 | 2019-12-17 | 5,000 | $5.24 | $26.2K | 5,000 | SEC↗ |
| Hudson Frederick M. | Director | A Award deriv | 2019-06-18 | 2019-06-20 | 6,124 | — | $0 | 6,124 | SEC↗ |
| Coleman Dorothy | Director | A Award deriv | 2019-06-18 | 2019-06-20 | 6,124 | — | $0 | 6,124 | SEC↗ |
| VEITINGER KLAUS R DR | Director | A Award deriv | 2019-06-18 | 2019-06-20 | 6,124 | — | $0 | 6,124 | SEC↗ |
| Khattar Jack A. | Director | A Award deriv | 2019-06-18 | 2019-06-20 | 6,124 | — | $0 | 6,124 | SEC↗ |
| Freeman Mason | Director | A Award deriv | 2019-06-18 | 2019-06-20 | 6,124 | — | $0 | 6,124 | SEC↗ |
| Agger Mette Kirstine | Director | A Award deriv | 2019-06-18 | 2019-06-20 | 6,124 | — | $0 | 6,124 | SEC↗ |
| Baylor-Henry Minnie | Director | A Award deriv | 2019-06-18 | 2019-06-20 | 6,124 | — | $0 | 6,124 | SEC↗ |
| SCHAEFFER LEONARD D | Director | A Award deriv | 2019-06-18 | 2019-06-20 | 6,124 | — | $0 | 6,124 | SEC↗ |
| RA Capital Healthcare Fund LP | 10% Owner | P Buy | 2019-04-11 | 2019-04-15 | 389,862 | $2.70 | $1.05M | 3,247,005 | SEC↗ |
| Freeman Mason | Director | A Award deriv | 2018-07-20 | 2018-07-24 | 12,248 | — | $0 | 12,248 | SEC↗ |
| Baylor-Henry Minnie | Director | A Award deriv | 2018-07-20 | 2018-07-24 | 12,248 | — | $0 | 12,248 | SEC↗ |
| Hudson Frederick M. | Director | A Award deriv | 2018-06-19 | 2018-06-21 | 12,248 | — | $0 | 12,248 | SEC↗ |
| Coleman Dorothy | Director | A Award deriv | 2018-06-19 | 2018-06-21 | 6,124 | — | $0 | 6,124 | SEC↗ |
| Khattar Jack A. | Director | A Award deriv | 2018-06-19 | 2018-06-21 | 6,124 | — | $0 | 6,124 | SEC↗ |
| SCHAEFFER LEONARD D | Director | A Award deriv | 2018-06-19 | 2018-06-21 | 6,124 | — | $0 | 6,124 | SEC↗ |
| PARMAR KUSH | Director | A Award deriv | 2018-06-19 | 2018-06-21 | 6,124 | — | $0 | 6,124 | SEC↗ |
| VEITINGER KLAUS R DR | Director | A Award deriv | 2018-06-19 | 2018-06-21 | 6,124 | — | $0 | 6,124 | SEC↗ |
| Agger Mette Kirstine | Director | A Award deriv | 2018-06-19 | 2018-06-21 | 6,124 | — | $0 | 6,124 | SEC↗ |
| Ceesay Abraham | Chief Operating Officer | A Award deriv | 2018-01-17 | 2018-01-19 | 80,971 | — | $0 | 80,971 | SEC↗ |
| Tucker John H | President and CEO | A Award deriv | 2018-01-17 | 2018-01-19 | 100,000 | — | $0 | 100,000 | SEC↗ |
| Ignelzi Troy A. | Chief Financial Officer | A Award deriv | 2018-01-17 | 2018-01-19 | 42,616 | — | $0 | 42,616 | SEC↗ |
| SCHAEFFER LEONARD D | Director | M Exercise deriv | 2017-12-19 | 2017-12-20 | 22,631 | — | $0 | 5,223 | SEC↗ |
| SCHAEFFER LEONARD D | Director | M Exercise | 2017-12-19 | 2017-12-20 | 22,631 | $1.66 | $37.6K | 57,449 | SEC↗ |
| Agger Mette Kirstine | Director, 10% Owner | P Buy | 2017-11-21 | 2018-02-13 | 654,762 | $14.00 | $9.17M | 3,183,986 | SEC↗ |
| ORBIMED ADVISORS LLC | 10% Owner | C Conversion deriv | 2017-11-21 | 2017-11-21 | 18,500,000 | — | $0 | 0 | SEC↗ |
| 5AM Co-Investors IV, L.P. | 10% Owner | C Conversion deriv | 2017-11-21 | 2017-11-21 | 7,263,649 | — | $0 | 0 | SEC↗ |
| 5AM Co-Investors IV, L.P. | 10% Owner | C Conversion deriv | 2017-11-21 | 2017-11-21 | 10,649,003 | — | $0 | 0 | SEC↗ |
| 5AM Co-Investors IV, L.P. | 10% Owner | C Conversion deriv | 2017-11-21 | 2017-11-21 | 443,708 | — | $0 | 0 | SEC↗ |
| 5AM Co-Investors IV, L.P. | 10% Owner | C Conversion deriv | 2017-11-21 | 2017-11-21 | 302,652 | — | $0 | 0 | SEC↗ |
| SILVERSTEIN JONATHAN | Director | C Conversion deriv | 2017-11-21 | 2017-11-21 | 18,500,000 | — | $0 | 0 | SEC↗ |
| Agger Mette Kirstine | Director | C Conversion deriv | 2017-11-21 | 2017-11-21 | 7,067,945 | — | $0 | 0 | SEC↗ |
| Agger Mette Kirstine | Director | C Conversion deriv | 2017-11-21 | 2017-11-21 | 11,092,383 | — | $0 | 0 | SEC↗ |
| Lundbeckfond Invest A/S | 10% Owner | C Conversion deriv | 2017-11-21 | 2017-11-21 | 11,092,383 | — | $0 | 0 | SEC↗ |
| Lundbeckfond Invest A/S | 10% Owner | C Conversion deriv | 2017-11-21 | 2017-11-21 | 7,067,945 | — | $0 | 0 | SEC↗ |
| Coleman Dorothy | Director | C Conversion deriv | 2017-11-21 | 2017-11-21 | 103,024 | — | $0 | 0 | SEC↗ |
| SCHAEFFER LEONARD D | Director | C Conversion deriv | 2017-11-21 | 2017-11-21 | 250,000 | — | $0 | 0 | SEC↗ |
| SCHAEFFER LEONARD D | Director | C Conversion deriv | 2017-11-21 | 2017-11-21 | 309,501 | — | $0 | 0 | SEC↗ |
| Sun Pharmaceutical Industries, | 10% Owner | C Conversion deriv | 2017-11-21 | 2017-11-24 | 13,000,000 | — | $0 | 0 | SEC↗ |
| ORBIMED ADVISORS LLC | 10% Owner | C Conversion | 2017-11-21 | 2017-11-21 | 2,576,532 | — | $0 | 2,576,532 | SEC↗ |
| ORBIMED ADVISORS LLC | 10% Owner | P Buy | 2017-11-21 | 2017-11-21 | 833,333 | $14.00 | $11.67M | 3,409,865 | SEC↗ |
| 5AM Co-Investors IV, L.P. | 10% Owner | C Conversion | 2017-11-21 | 2017-11-21 | 61,795 | — | $0 | 61,795 | SEC↗ |
| 5AM Co-Investors IV, L.P. | 10% Owner | C Conversion | 2017-11-21 | 2017-11-21 | 1,483,107 | — | $0 | 1,483,107 | SEC↗ |
| 5AM Co-Investors IV, L.P. | 10% Owner | P Buy | 2017-11-21 | 2017-11-21 | 26,190 | $14.00 | $366.7K | 130,135 | SEC↗ |
| 5AM Co-Investors IV, L.P. | 10% Owner | C Conversion | 2017-11-21 | 2017-11-21 | 42,150 | — | $0 | 103,945 | SEC↗ |
| 5AM Co-Investors IV, L.P. | 10% Owner | P Buy | 2017-11-21 | 2017-11-21 | 628,572 | $14.00 | $8.80M | 3,123,302 | SEC↗ |
| 5AM Co-Investors IV, L.P. | 10% Owner | C Conversion | 2017-11-21 | 2017-11-21 | 1,011,623 | — | $0 | 2,494,730 | SEC↗ |
| SILVERSTEIN JONATHAN | Director | C Conversion | 2017-11-21 | 2017-11-21 | 2,576,532 | — | $0 | 2,576,532 | SEC↗ |
| Agger Mette Kirstine | Director | C Conversion | 2017-11-21 | 2017-11-21 | 1,544,858 | — | $0 | 1,544,858 | SEC↗ |
| Agger Mette Kirstine | Director | C Conversion | 2017-11-21 | 2017-11-21 | 984,366 | — | $0 | 2,529,224 | SEC↗ |
| Lundbeckfond Invest A/S | 10% Owner | C Conversion | 2017-11-21 | 2017-11-21 | 984,366 | — | $0 | 2,529,224 | SEC↗ |
| Lundbeckfond Invest A/S | 10% Owner | C Conversion | 2017-11-21 | 2017-11-21 | 1,544,858 | — | $0 | 1,544,858 | SEC↗ |
| Lundbeckfond Invest A/S | 10% Owner | P Buy | 2017-11-21 | 2017-11-21 | 654,762 | $14.00 | $9.17M | 3,183,986 | SEC↗ |
| Coleman Dorothy | Director | C Conversion | 2017-11-21 | 2017-11-21 | 14,348 | — | $0 | 14,348 | SEC↗ |
| SCHAEFFER LEONARD D | Director | C Conversion | 2017-11-21 | 2017-11-21 | 34,818 | — | $0 | 34,818 | SEC↗ |
| SCHAEFFER LEONARD D | Director | C Conversion | 2017-11-21 | 2017-11-21 | 43,104 | — | $0 | 43,104 | SEC↗ |
| Sun Pharmaceutical Industries, | 10% Owner | C Conversion | 2017-11-21 | 2017-11-24 | 1,810,536 | — | $0 | 1,810,536 | SEC↗ |
| Sun Pharmaceutical Industries, | 10% Owner | P Buy | 2017-11-21 | 2017-11-24 | 357,143 | $14.00 | $5.00M | 357,143 | SEC↗ |