Open-mkt buys · 90d
—
0 trades · 0 insiders
Open-mkt sales · 90d
—
0 trades · 0 insiders
Net · 90d
$0
Insiders on file
42
Daily buy vs sell · 90 days
No data yet.
Insiders
| Insider | Role | Trades | Bought | Sold | Last trade |
|---|---|---|---|---|---|
| Huang Michael F. | Sr. VP of Clinical Development | 24 | $0 | $1.21M | 2026-05-18 |
| Joshi Manher | Chief Development Officer | 7 | $0 | $0 | 2026-05-18 |
| Fulk Jennifer | CHIEF FINANCIAL OFFICER | 4 | $0 | $0 | 2026-05-18 |
| Norrett Kevin | Chief Business Officer | 7 | $0 | $0 | 2026-05-18 |
| Hirano Patricia C | See Remarks | 92 | $0 | $13.39M | 2026-05-18 |
| Sinclair Andrew | Director | 25 | $15.78M | $0 | 2026-05-18 |
| Volck Birgitte | Director | 26 | $0 | $0 | 2026-05-18 |
| Manning Meredith | Chief Commercial Officer | 24 | $0 | $3.27M | 2026-05-18 |
| Bir Dawn Carter | Director | 3 | $0 | $0 | 2026-05-18 |
| Yen Kristen | Vice President, Clinical Opera | 81 | $0 | $9.70M | 2026-05-18 |
| Anish Bhatnagar | See Remarks | 96 | $0 | $67.89M | 2026-05-18 |
| Pauls Matthew | Director | 8 | $0 | $424.8K | 2026-05-18 |
| Hahn Mark W | Director | 2 | $0 | $0 | 2026-05-18 |
| Mackaness James H | Chief Financial Officer | 76 | $20.0K | $10.42M | 2026-01-21 |
| Harris William G | Director | 28 | $0 | $4.3K | 2025-06-05 |
| Vivo Opportunity Fund Holdings, L.P. | 10% Owner | 9 | $0 | $176.15M | 2025-03-28 |
| Vivo Opportunity, LLC | 10% Owner | 3 | $0 | $49.21M | 2024-08-29 |
| Urbanski Raymond W. | CHIEF DEVELOPMENT OFFICER | 1 | $0 | $0 | 2024-08-13 |
| MARIO ERNEST | Director, 10% Owner | 42 | $0 | $0 | 2024-06-06 |
| Carlyle Holdings I GP Sub L.L.C. | 10% Owner | 3 | $0 | $0 | 2023-09-28 |
| PERCEPTIVE ADVISORS LLC | 10% Owner | 22 | $21.37M | $0 | 2023-09-28 |
| PERCEPTIVE LIFE SCIENCES MASTER FUND LTD | 10% Owner | 3 | $188.2K | $0 | 2023-06-01 |
| Melincoff Gwen A | Director | 9 | $15.4K | $0 | 2023-05-26 |
| EDELMAN JOSEPH | 10% Owner | 3 | $449.8K | $0 | 2023-05-26 |
| Carlyle Holdings I L.P. | 10% Owner | 2 | $1.26M | $0 | 2023-05-08 |
| SCHULER JACK W | 10% Owner | 118 | $22.91M | $5.01M | 2022-12-09 |
| Abingworth LLP | 10% Owner | 9 | $8.26M | $0 | 2022-03-29 |
| COLLINSON STUART J | Director, 10% Owner | 8 | $0 | $0 | 2020-07-31 |
| ORACLE PARTNERS LP | 10% Owner | 4 | $122.1K | $677.9K | 2020-06-08 |
| Vivo Ventures V, LLC | 10% Owner | 5 | $0 | $83.1K | 2019-12-02 |
| Vivo Ventures V Affiliates Fund, L.P. | 10% Owner | 16 | $2.00M | $294.6K | 2019-11-25 |
| Vivo Ventures Fund V, L.P. | 10% Owner | 7 | $0 | $602.9K | 2019-11-20 |
| BIOASIA INVESTMENTS IV LLC | 10% Owner | 4 | $0 | $174.9K | 2019-05-20 |
| FEINBERG LARRY N | 10% Owner | 16 | $2.25M | $0 | 2019-03-14 |
| Wolter Jonathan | Chief Financial Officer | 2 | $0 | $0 | 2019-01-24 |
| TECHNOLOGY PARTNERS AFFILIATES VII LP | 10% Owner | 10 | $0 | $46.1K | 2018-09-13 |
| Glasheen James Walter | Director, 10% Owner | 4 | $0 | $0 | 2018-06-11 |
| SHAH MAHENDRA | Director | 4 | $0 | $0 | 2018-06-11 |
| DALAL RAJEN | Director | 4 | $0 | $0 | 2018-06-11 |
| Kirnon Stephen | Director | 3 | $0 | $0 | 2018-02-05 |
| ENGLEMAN EDGAR | Director, 10% Owner | 7 | $2.00M | $0 | 2018-02-05 |
| ENGELSEN STEINAR J | Director | 3 | $0 | $0 | 2018-02-05 |
Trade history
| Insider | Role | Code | Trade | Filed | Shares | Price | Value | Owned after | |
|---|---|---|---|---|---|---|---|---|---|
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | D To issuer deriv | 2026-05-18 | 2026-05-18 | 100,000 | — | $0 | 0 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | D To issuer deriv | 2026-05-18 | 2026-05-18 | 200,753 | — | $0 | 0 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | D To issuer deriv | 2026-05-18 | 2026-05-18 | 52,709 | — | $0 | 0 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | D To issuer deriv | 2026-05-18 | 2026-05-18 | 73,333 | — | $0 | 0 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | D To issuer deriv | 2026-05-18 | 2026-05-18 | 8,473 | — | $0 | 0 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | D To issuer deriv | 2026-05-18 | 2026-05-18 | 35,000 | — | $0 | 0 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | D To issuer deriv | 2026-05-18 | 2026-05-18 | 23,332 | — | $0 | 0 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | D To issuer deriv | 2026-05-18 | 2026-05-18 | 60 | — | $0 | 0 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | D To issuer deriv | 2026-05-18 | 2026-05-18 | 22,452 | — | $0 | 0 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | D To issuer deriv | 2026-05-18 | 2026-05-18 | 131,400 | — | $0 | 0 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | D To issuer deriv | 2026-05-18 | 2026-05-18 | 115,600 | — | $0 | 0 | SEC↗ |
| Fulk Jennifer | CHIEF FINANCIAL OFFICER | D To issuer deriv | 2026-05-18 | 2026-05-18 | 67,660 | — | $0 | 0 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | D To issuer deriv | 2026-05-18 | 2026-05-18 | 16,000 | — | $0 | 0 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | D To issuer deriv | 2026-05-18 | 2026-05-18 | 49,262 | — | $0 | 0 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | D To issuer deriv | 2026-05-18 | 2026-05-18 | 11,667 | — | $0 | 0 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | D To issuer deriv | 2026-05-18 | 2026-05-18 | 1,333 | — | $0 | 0 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | D To issuer deriv | 2026-05-18 | 2026-05-18 | 18,842 | — | $0 | 0 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | D To issuer deriv | 2026-05-18 | 2026-05-18 | 2,333 | — | $0 | 0 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | D To issuer deriv | 2026-05-18 | 2026-05-18 | 13,800 | — | $0 | 0 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | D To issuer deriv | 2026-05-18 | 2026-05-18 | 11,900 | — | $0 | 0 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | D To issuer deriv | 2026-05-18 | 2026-05-18 | 2,445 | — | $0 | 0 | SEC↗ |
| Huang Michael F. | Sr. VP of Clinical Developme | D To issuer deriv | 2026-05-18 | 2026-05-18 | 13,800 | — | $0 | 0 | SEC↗ |
| Huang Michael F. | Sr. VP of Clinical Developme | D To issuer deriv | 2026-05-18 | 2026-05-18 | 110,000 | — | $0 | 0 | SEC↗ |
| Huang Michael F. | Sr. VP of Clinical Developme | D To issuer deriv | 2026-05-18 | 2026-05-18 | 11,900 | — | $0 | 0 | SEC↗ |
| Joshi Manher | Chief Development Officer | D To issuer deriv | 2026-05-18 | 2026-05-18 | 4,700 | — | $0 | 0 | SEC↗ |
| Joshi Manher | Chief Development Officer | D To issuer deriv | 2026-05-18 | 2026-05-18 | 72,321 | — | $0 | 0 | SEC↗ |
| Manning Meredith | Chief Commercial Officer | D To issuer deriv | 2026-05-18 | 2026-05-18 | 32,800 | — | $0 | 0 | SEC↗ |
| Manning Meredith | Chief Commercial Officer | D To issuer deriv | 2026-05-18 | 2026-05-18 | 29,200 | — | $0 | 0 | SEC↗ |
| Manning Meredith | Chief Commercial Officer | D To issuer deriv | 2026-05-18 | 2026-05-18 | 91,000 | — | $0 | 0 | SEC↗ |
| Norrett Kevin | Chief Business Officer | D To issuer deriv | 2026-05-18 | 2026-05-18 | 64,286 | — | $0 | 0 | SEC↗ |
| Norrett Kevin | Chief Business Officer | D To issuer deriv | 2026-05-18 | 2026-05-18 | 4,000 | — | $0 | 0 | SEC↗ |
| Pauls Matthew | Director | D To issuer deriv | 2026-05-18 | 2026-05-18 | 9,063 | — | $0 | 0 | SEC↗ |
| Sinclair Andrew | Director | D To issuer deriv | 2026-05-18 | 2026-05-18 | 2,666 | — | $0 | 0 | SEC↗ |
| Sinclair Andrew | Director | D To issuer deriv | 2026-05-18 | 2026-05-18 | 635 | — | $0 | 0 | SEC↗ |
| Sinclair Andrew | Director | D To issuer deriv | 2026-05-18 | 2026-05-18 | 823 | — | $0 | 0 | SEC↗ |
| Sinclair Andrew | Director | D To issuer deriv | 2026-05-18 | 2026-05-18 | 1,333 | — | $0 | 0 | SEC↗ |
| Sinclair Andrew | Director | D To issuer deriv | 2026-05-18 | 2026-05-18 | 2,666 | — | $0 | 0 | SEC↗ |
| Sinclair Andrew | Director | D To issuer deriv | 2026-05-18 | 2026-05-18 | 2,666 | — | $0 | 0 | SEC↗ |
| Sinclair Andrew | Director | D To issuer deriv | 2026-05-18 | 2026-05-18 | 2,124 | — | $0 | 0 | SEC↗ |
| Sinclair Andrew | Director | D To issuer deriv | 2026-05-18 | 2026-05-18 | 10,000 | — | $0 | 0 | SEC↗ |
| Volck Birgitte | Director | D To issuer deriv | 2026-05-18 | 2026-05-18 | 1,333 | — | $0 | 0 | SEC↗ |
| Volck Birgitte | Director | D To issuer deriv | 2026-05-18 | 2026-05-18 | 635 | — | $0 | 0 | SEC↗ |
| Volck Birgitte | Director | D To issuer deriv | 2026-05-18 | 2026-05-18 | 2,666 | — | $0 | 0 | SEC↗ |
| Volck Birgitte | Director | D To issuer deriv | 2026-05-18 | 2026-05-18 | 2,124 | — | $0 | 0 | SEC↗ |
| Volck Birgitte | Director | D To issuer deriv | 2026-05-18 | 2026-05-18 | 2,666 | — | $0 | 0 | SEC↗ |
| Volck Birgitte | Director | D To issuer deriv | 2026-05-18 | 2026-05-18 | 10,000 | — | $0 | 0 | SEC↗ |
| Volck Birgitte | Director | D To issuer deriv | 2026-05-18 | 2026-05-18 | 2,666 | — | $0 | 0 | SEC↗ |
| Yen Kristen | SEE REMARKS | D To issuer deriv | 2026-05-18 | 2026-05-18 | 4,000 | — | $0 | 0 | SEC↗ |
| Yen Kristen | SEE REMARKS | D To issuer deriv | 2026-05-18 | 2026-05-18 | 1,741 | — | $0 | 0 | SEC↗ |
| Yen Kristen | SEE REMARKS | D To issuer deriv | 2026-05-18 | 2026-05-18 | 4,999 | — | $0 | 0 | SEC↗ |
| Yen Kristen | SEE REMARKS | D To issuer deriv | 2026-05-18 | 2026-05-18 | 666 | — | $0 | 0 | SEC↗ |
| Yen Kristen | SEE REMARKS | D To issuer deriv | 2026-05-18 | 2026-05-18 | 18,800 | — | $0 | 0 | SEC↗ |
| Yen Kristen | SEE REMARKS | D To issuer deriv | 2026-05-18 | 2026-05-18 | 2,445 | — | $0 | 0 | SEC↗ |
| Yen Kristen | SEE REMARKS | D To issuer deriv | 2026-05-18 | 2026-05-18 | 11,667 | — | $0 | 0 | SEC↗ |
| Yen Kristen | SEE REMARKS | D To issuer deriv | 2026-05-18 | 2026-05-18 | 55,392 | — | $0 | 0 | SEC↗ |
| Yen Kristen | SEE REMARKS | D To issuer deriv | 2026-05-18 | 2026-05-18 | 16,000 | — | $0 | 0 | SEC↗ |
| Yen Kristen | SEE REMARKS | D To issuer deriv | 2026-05-18 | 2026-05-18 | 13,800 | — | $0 | 0 | SEC↗ |
| Yen Kristen | SEE REMARKS | D To issuer deriv | 2026-05-18 | 2026-05-18 | 11,900 | — | $0 | 0 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | D To issuer | 2026-05-18 | 2026-05-18 | 583,656 | — | $0 | 0 | SEC↗ |
| Bir Dawn Carter | Director | D To issuer | 2026-05-18 | 2026-05-18 | 16,991 | — | $0 | 0 | SEC↗ |
| Fulk Jennifer | CHIEF FINANCIAL OFFICER | D To issuer | 2026-05-18 | 2026-05-18 | 39,200 | — | $0 | 0 | SEC↗ |
| Hahn Mark W | Director | D To issuer | 2026-05-18 | 2026-05-18 | 10,046 | — | $0 | 0 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | D To issuer | 2026-05-18 | 2026-05-18 | 22,702 | — | $0 | 0 | SEC↗ |
| Huang Michael F. | Sr. VP of Clinical Developme | D To issuer | 2026-05-18 | 2026-05-18 | 39,823 | — | $0 | 0 | SEC↗ |
| Joshi Manher | Chief Development Officer | D To issuer | 2026-05-18 | 2026-05-18 | 20,171 | — | $0 | 0 | SEC↗ |
| Manning Meredith | Chief Commercial Officer | D To issuer | 2026-05-18 | 2026-05-18 | 64,507 | — | $0 | 0 | SEC↗ |
| Norrett Kevin | Chief Business Officer | D To issuer | 2026-05-18 | 2026-05-18 | 17,786 | — | $0 | 0 | SEC↗ |
| Pauls Matthew | Director | D To issuer | 2026-05-18 | 2026-05-18 | 10,491 | — | $0 | 0 | SEC↗ |
| Sinclair Andrew | Director | D To issuer | 2026-05-18 | 2026-05-18 | 10,491 | — | $0 | 0 | SEC↗ |
| Volck Birgitte | Director | D To issuer | 2026-05-18 | 2026-05-18 | 17,536 | — | $0 | 0 | SEC↗ |
| Yen Kristen | SEE REMARKS | D To issuer | 2026-05-18 | 2026-05-18 | 37,639 | — | $0 | 0 | SEC↗ |
| Huang Michael F. | Sr. VP of Clinical Developme | S Sale | 2026-03-27 | 2026-03-31 | 1,838 | $31.04 | $57.1K | 40,311 | SEC↗ |
| Huang Michael F. | Sr. VP of Clinical Developme | S Sale | 2026-03-27 | 2026-03-31 | 488 | $31.72 | $15.5K | 39,823 | SEC↗ |
| Huang Michael F. | Sr. VP of Clinical Developme | S Sale | 2026-03-27 | 2026-03-31 | 4,256 | $30.04 | $127.9K | 42,149 | SEC↗ |
| Manning Meredith | Chief Commercial Officer | S Sale | 2026-03-27 | 2026-03-31 | 4,864 | $30.04 | $146.1K | 67,165 | SEC↗ |
| Manning Meredith | Chief Commercial Officer | S Sale | 2026-03-27 | 2026-03-31 | 2,100 | $31.04 | $65.2K | 65,065 | SEC↗ |
| Manning Meredith | Chief Commercial Officer | S Sale | 2026-03-27 | 2026-03-31 | 558 | $31.72 | $17.7K | 64,507 | SEC↗ |
| Fulk Jennifer | CHIEF FINANCIAL OFFICER | M Exercise deriv | 2026-03-02 | 2026-03-04 | 67,660 | — | $0 | 67,660 | SEC↗ |
| Fulk Jennifer | CHIEF FINANCIAL OFFICER | A Award | 2026-03-02 | 2026-03-04 | 39,200 | — | $0 | 39,200 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | A Award deriv | 2026-01-21 | 2026-01-23 | 131,400 | — | $0 | 131,400 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | A Award deriv | 2026-01-21 | 2026-01-23 | 11,900 | — | $0 | 11,900 | SEC↗ |
| Huang Michael F. | Sr. VP of Clinical Developme | A Award deriv | 2026-01-21 | 2026-01-23 | 11,900 | — | $0 | 11,900 | SEC↗ |
| Joshi Manher | Chief Development Officer | A Award deriv | 2026-01-21 | 2026-01-23 | 4,700 | — | $0 | 4,700 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | A Award deriv | 2026-01-21 | 2026-01-23 | 32,800 | — | $0 | 32,800 | SEC↗ |
| Manning Meredith | Chief Commercial Officer | A Award deriv | 2026-01-21 | 2026-01-23 | 32,800 | — | $0 | 32,800 | SEC↗ |
| Norrett Kevin | Chief Business Officer | A Award deriv | 2026-01-21 | 2026-01-23 | 4,000 | — | $0 | 4,000 | SEC↗ |
| Yen Kristen | SEE REMARKS | A Award deriv | 2026-01-21 | 2026-01-23 | 11,900 | — | $0 | 11,900 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | A Award | 2026-01-21 | 2026-01-23 | 114,200 | — | $0 | 583,656 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | A Award | 2026-01-21 | 2026-01-23 | 10,400 | — | $0 | 22,702 | SEC↗ |
| Huang Michael F. | Sr. VP of Clinical Developme | A Award | 2026-01-21 | 2026-01-23 | 10,400 | — | $0 | 46,405 | SEC↗ |
| Joshi Manher | Chief Development Officer | A Award | 2026-01-21 | 2026-01-23 | 4,100 | — | $0 | 20,171 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | A Award | 2026-01-21 | 2026-01-23 | 28,600 | — | $0 | 131,763 | SEC↗ |
| Manning Meredith | Chief Commercial Officer | A Award | 2026-01-21 | 2026-01-23 | 28,600 | — | $0 | 72,029 | SEC↗ |
| Norrett Kevin | Chief Business Officer | A Award | 2026-01-21 | 2026-01-23 | 3,500 | — | $0 | 17,786 | SEC↗ |
| Yen Kristen | SEE REMARKS | A Award | 2026-01-21 | 2026-01-23 | 10,400 | — | $0 | 37,639 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | G Gift | 2025-12-15 | 2025-12-17 | 100,000 | — | $0 | 469,456 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | F Tax w/h | 2025-12-15 | 2025-12-17 | 7,620 | $49.95 | $380.6K | 569,456 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | F Tax w/h | 2025-12-15 | 2025-12-17 | 904 | $49.95 | $45.2K | 12,302 | SEC↗ |
| Huang Michael F. | Sr. VP of Clinical Developme | F Tax w/h | 2025-12-15 | 2025-12-17 | 812 | $49.95 | $40.6K | 36,005 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | F Tax w/h | 2025-12-15 | 2025-12-17 | 2,013 | $49.95 | $100.5K | 103,163 | SEC↗ |
| Manning Meredith | Chief Commercial Officer | F Tax w/h | 2025-12-15 | 2025-12-17 | 1,922 | $49.95 | $96.0K | 43,429 | SEC↗ |
| Yen Kristen | SEE REMARKS | F Tax w/h | 2025-12-15 | 2025-12-17 | 904 | $49.95 | $45.2K | 27,239 | SEC↗ |
| Norrett Kevin | Chief Business Officer | M Exercise deriv | 2025-11-17 | 2025-11-19 | 64,286 | — | $0 | 64,286 | SEC↗ |
| Norrett Kevin | Chief Business Officer | A Award | 2025-11-17 | 2025-11-19 | 14,286 | — | $0 | 14,286 | SEC↗ |
| Joshi Manher | Chief Development Officer | M Exercise deriv | 2025-11-10 | 2025-11-12 | 72,321 | — | $0 | 72,321 | SEC↗ |
| Joshi Manher | Chief Development Officer | A Award | 2025-11-10 | 2025-11-12 | 16,071 | — | $0 | 16,071 | SEC↗ |
| Hahn Mark W | Director | A Award | 2025-10-13 | 2025-10-14 | 10,046 | — | $0 | 10,046 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2025-07-01 | 2025-07-03 | 3,830 | $82.76 | $317.0K | 13,206 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | M Exercise deriv | 2025-06-24 | 2025-06-26 | 266 | — | $0 | 0 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | M Exercise | 2025-06-24 | 2025-06-26 | 266 | $44.25 | $11.8K | 17,302 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2025-06-24 | 2025-06-26 | 266 | $84.25 | $22.4K | 17,036 | SEC↗ |
| Bir Dawn Carter | Director | A Award | 2025-06-05 | 2025-06-09 | 3,991 | — | $0 | 16,991 | SEC↗ |
| Harris William G | Director | A Award | 2025-06-05 | 2025-06-09 | 3,991 | — | $0 | 19,392 | SEC↗ |
| Pauls Matthew | Director | A Award | 2025-06-05 | 2025-06-09 | 3,991 | — | $0 | 10,491 | SEC↗ |
| Sinclair Andrew | Director | A Award | 2025-06-05 | 2025-06-09 | 3,991 | — | $0 | 10,491 | SEC↗ |
| Volck Birgitte | Director | A Award | 2025-06-05 | 2025-06-09 | 3,991 | — | $0 | 17,536 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2025-04-01 | 2025-04-02 | 3,782 | $70.11 | $265.2K | 27,036 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | M Exercise deriv | 2025-03-28 | 2025-03-31 | 2,691 | — | $0 | 18,842 | SEC↗ |
| Pauls Matthew | Director | M Exercise deriv | 2025-03-28 | 2025-03-31 | 5,937 | — | $0 | 9,063 | SEC↗ |
| Vivo Opportunity Fund Holdings | 10% Owner | S Sale | 2025-03-28 | 2025-03-28 | 333,557 | $70.60 | $23.55M | 4,458,294 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2025-03-28 | 2025-03-31 | 2,691 | $73.60 | $198.1K | 30,818 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2025-03-28 | 2025-03-31 | 9,253 | $69.52 | $643.3K | 33,509 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2025-03-28 | 2025-03-31 | 12,324 | $68.92 | $849.4K | 42,762 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2025-03-28 | 2025-03-31 | 3,394 | $67.46 | $229.0K | 55,086 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | M Exercise | 2025-03-28 | 2025-03-31 | 2,691 | $33.60 | $90.4K | 58,480 | SEC↗ |
| Pauls Matthew | Director | S Sale | 2025-03-28 | 2025-03-31 | 5,937 | $71.55 | $424.8K | 6,500 | SEC↗ |
| Pauls Matthew | Director | M Exercise | 2025-03-28 | 2025-03-31 | 5,937 | $4.60 | $27.3K | 12,437 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | M Exercise deriv | 2025-03-27 | 2025-03-31 | 281,053 | — | $0 | 200,753 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | M Exercise deriv | 2025-03-27 | 2025-03-31 | 26,606 | — | $0 | 60 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | M Exercise deriv | 2025-03-27 | 2025-03-31 | 16,666 | — | $0 | 0 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | M Exercise deriv | 2025-03-27 | 2025-03-31 | 105,000 | — | $0 | 35,000 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | M Exercise deriv | 2025-03-27 | 2025-03-31 | 32,193 | — | $0 | 8,473 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | M Exercise deriv | 2025-03-27 | 2025-03-31 | 62,291 | — | $0 | 52,709 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | M Exercise deriv | 2025-03-27 | 2025-03-31 | 6,000 | — | $0 | 0 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | M Exercise deriv | 2025-03-27 | 2025-03-31 | 4,400 | — | $0 | 0 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | M Exercise deriv | 2025-03-27 | 2025-03-31 | 4,888 | — | $0 | 2,445 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | M Exercise deriv | 2025-03-27 | 2025-03-31 | 13,333 | — | $0 | 0 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | M Exercise deriv | 2025-03-27 | 2025-03-31 | 8,333 | — | $0 | 11,667 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | M Exercise deriv | 2025-03-27 | 2025-03-31 | 35,186 | — | $0 | 49,262 | SEC↗ |
| Huang Michael F. | Sr. VP of Clinical Developme | M Exercise deriv | 2025-03-27 | 2025-03-31 | 10,000 | — | $0 | 110,000 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | M Exercise deriv | 2025-03-27 | 2025-03-31 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | M Exercise deriv | 2025-03-27 | 2025-03-31 | 20,000 | — | $0 | 0 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | M Exercise deriv | 2025-03-27 | 2025-03-31 | 5,000 | — | $0 | 0 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | M Exercise deriv | 2025-03-27 | 2025-03-31 | 20,000 | — | $0 | 67,251 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | M Exercise deriv | 2025-03-27 | 2025-03-31 | 10,000 | — | $0 | 3,000 | SEC↗ |
| Manning Meredith | Chief Commercial Officer | M Exercise deriv | 2025-03-27 | 2025-03-31 | 37,000 | — | $0 | 91,000 | SEC↗ |
| Yen Kristen | SEE REMARKS | M Exercise deriv | 2025-03-27 | 2025-03-31 | 32,000 | — | $0 | 55,392 | SEC↗ |
| Yen Kristen | SEE REMARKS | M Exercise deriv | 2025-03-27 | 2025-03-31 | 3,750 | — | $0 | 11,667 | SEC↗ |
| Yen Kristen | SEE REMARKS | M Exercise deriv | 2025-03-27 | 2025-03-31 | 4,888 | — | $0 | 2,445 | SEC↗ |
| Vivo Opportunity Fund Holdings | 10% Owner | S Sale | 2025-03-27 | 2025-03-28 | 1,100,000 | $67.80 | $74.58M | 4,791,851 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | S Sale | 2025-03-27 | 2025-03-31 | 55,234 | $68.79 | $3.80M | 617,861 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | S Sale | 2025-03-27 | 2025-03-31 | 23,095 | $66.79 | $1.54M | 715,084 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | S Sale | 2025-03-27 | 2025-03-31 | 199,226 | $69.30 | $13.81M | 577,076 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | S Sale | 2025-03-27 | 2025-03-31 | 8,423 | $67.37 | $567.5K | 776,302 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | S Sale | 2025-03-27 | 2025-03-31 | 209,689 | $66.33 | $13.91M | 784,725 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | S Sale | 2025-03-27 | 2025-03-31 | 106,471 | $65.81 | $7.01M | 994,414 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | M Exercise | 2025-03-27 | 2025-03-31 | 281,053 | $5.25 | $1.48M | 1,100,885 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | M Exercise | 2025-03-27 | 2025-03-31 | 62,291 | $2.41 | $150.1K | 819,832 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | M Exercise | 2025-03-27 | 2025-03-31 | 32,193 | $5.10 | $164.2K | 757,541 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | M Exercise | 2025-03-27 | 2025-03-31 | 105,000 | $33.60 | $3.53M | 725,348 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | M Exercise | 2025-03-27 | 2025-03-31 | 16,666 | $25.05 | $417.5K | 620,348 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | M Exercise | 2025-03-27 | 2025-03-31 | 26,606 | $24.00 | $638.5K | 603,682 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | S Sale | 2025-03-27 | 2025-03-31 | 732 | $72.64 | $53.2K | 577,076 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | S Sale | 2025-03-27 | 2025-03-31 | 4,782 | $71.74 | $343.1K | 577,808 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | S Sale | 2025-03-27 | 2025-03-31 | 3,291 | $70.73 | $232.8K | 582,590 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | S Sale | 2025-03-27 | 2025-03-31 | 31,980 | $69.84 | $2.23M | 585,881 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | S Sale | 2025-03-27 | 2025-03-31 | 14,183 | $65.97 | $935.7K | 738,179 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | S Sale | 2025-03-27 | 2025-03-31 | 41,989 | $67.70 | $2.84M | 673,095 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2025-03-27 | 2025-03-31 | 1,418 | $65.97 | $93.5K | 110,884 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2025-03-27 | 2025-03-31 | 3,198 | $69.84 | $223.3K | 95,653 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2025-03-27 | 2025-03-31 | 2,310 | $66.79 | $154.3K | 108,574 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2025-03-27 | 2025-03-31 | 15,145 | $72.50 | $1.10M | 55,789 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2025-03-27 | 2025-03-31 | 24,989 | $70.18 | $1.75M | 70,934 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2025-03-27 | 2025-03-31 | 24,776 | $67.47 | $1.67M | 95,923 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2025-03-27 | 2025-03-31 | 46,214 | $66.39 | $3.07M | 120,699 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | M Exercise | 2025-03-27 | 2025-03-31 | 35,186 | $5.25 | $184.7K | 166,913 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | M Exercise | 2025-03-27 | 2025-03-31 | 8,333 | $2.41 | $20.1K | 131,727 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | M Exercise | 2025-03-27 | 2025-03-31 | 13,333 | $2.60 | $34.7K | 123,394 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | M Exercise | 2025-03-27 | 2025-03-31 | 4,888 | $5.10 | $24.9K | 110,061 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | M Exercise | 2025-03-27 | 2025-03-31 | 4,400 | $25.05 | $110.2K | 105,173 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | M Exercise | 2025-03-27 | 2025-03-31 | 6,000 | $24.00 | $144.0K | 100,773 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2025-03-27 | 2025-03-31 | 73 | $72.64 | $5.3K | 94,773 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2025-03-27 | 2025-03-31 | 478 | $71.74 | $34.3K | 94,846 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2025-03-27 | 2025-03-31 | 329 | $70.73 | $23.3K | 95,324 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2025-03-27 | 2025-03-31 | 4,199 | $67.70 | $284.3K | 104,375 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2025-03-27 | 2025-03-31 | 5,524 | $68.79 | $380.0K | 98,851 | SEC↗ |
| Huang Michael F. | Sr. VP of Clinical Developme | S Sale | 2025-03-27 | 2025-03-31 | 371 | $65.97 | $24.5K | 41,029 | SEC↗ |
| Huang Michael F. | Sr. VP of Clinical Developme | S Sale | 2025-03-27 | 2025-03-31 | 10,000 | $70.03 | $700.3K | 36,817 | SEC↗ |
| Huang Michael F. | Sr. VP of Clinical Developme | M Exercise | 2025-03-27 | 2025-03-31 | 10,000 | $21.93 | $219.3K | 46,817 | SEC↗ |
| Huang Michael F. | Sr. VP of Clinical Developme | S Sale | 2025-03-27 | 2025-03-31 | 19 | $72.64 | $1.4K | 36,817 | SEC↗ |
| Huang Michael F. | Sr. VP of Clinical Developme | S Sale | 2025-03-27 | 2025-03-31 | 125 | $71.74 | $9.0K | 36,836 | SEC↗ |
| Huang Michael F. | Sr. VP of Clinical Developme | S Sale | 2025-03-27 | 2025-03-31 | 86 | $70.73 | $6.1K | 36,961 | SEC↗ |
| Huang Michael F. | Sr. VP of Clinical Developme | S Sale | 2025-03-27 | 2025-03-31 | 836 | $69.84 | $58.4K | 37,047 | SEC↗ |
| Huang Michael F. | Sr. VP of Clinical Developme | S Sale | 2025-03-27 | 2025-03-31 | 1,444 | $68.79 | $99.3K | 37,883 | SEC↗ |
| Huang Michael F. | Sr. VP of Clinical Developme | S Sale | 2025-03-27 | 2025-03-31 | 1,098 | $67.70 | $74.3K | 39,327 | SEC↗ |
| Huang Michael F. | Sr. VP of Clinical Developme | S Sale | 2025-03-27 | 2025-03-31 | 604 | $66.79 | $40.3K | 40,425 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | M Exercise | 2025-03-27 | 2025-03-31 | 20,000 | $30.75 | $615.0K | 125,176 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | S Sale | 2025-03-27 | 2025-03-31 | 387 | $70.73 | $27.4K | 105,825 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | S Sale | 2025-03-27 | 2025-03-31 | 3,762 | $69.84 | $262.7K | 106,212 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | S Sale | 2025-03-27 | 2025-03-31 | 6,498 | $68.79 | $447.0K | 109,974 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | S Sale | 2025-03-27 | 2025-03-31 | 4,940 | $67.70 | $334.4K | 116,472 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | S Sale | 2025-03-27 | 2025-03-31 | 2,717 | $66.79 | $181.5K | 121,412 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | S Sale | 2025-03-27 | 2025-03-31 | 1,669 | $65.97 | $110.1K | 124,129 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | S Sale | 2025-03-27 | 2025-03-31 | 8,044 | $70.80 | $569.5K | 105,176 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | S Sale | 2025-03-27 | 2025-03-31 | 36,157 | $70.03 | $2.53M | 113,220 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | S Sale | 2025-03-27 | 2025-03-31 | 25,799 | $69.07 | $1.78M | 149,377 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | M Exercise | 2025-03-27 | 2025-03-31 | 20,000 | $5.25 | $105.0K | 175,176 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | M Exercise | 2025-03-27 | 2025-03-31 | 15,000 | $2.41 | $36.1K | 155,176 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | M Exercise | 2025-03-27 | 2025-03-31 | 5,000 | $2.60 | $13.0K | 140,176 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | M Exercise | 2025-03-27 | 2025-03-31 | 10,000 | $5.10 | $51.0K | 135,176 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | S Sale | 2025-03-27 | 2025-03-31 | 563 | $71.74 | $40.4K | 105,262 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | S Sale | 2025-03-27 | 2025-03-31 | 86 | $72.64 | $6.2K | 105,176 | SEC↗ |
| Manning Meredith | Chief Commercial Officer | S Sale | 2025-03-27 | 2025-03-31 | 37,000 | $67.04 | $2.48M | 45,351 | SEC↗ |
| Manning Meredith | Chief Commercial Officer | S Sale | 2025-03-27 | 2025-03-31 | 668 | $65.97 | $44.1K | 52,932 | SEC↗ |
| Manning Meredith | Chief Commercial Officer | S Sale | 2025-03-27 | 2025-03-31 | 1,087 | $66.79 | $72.6K | 51,845 | SEC↗ |
| Manning Meredith | Chief Commercial Officer | S Sale | 2025-03-27 | 2025-03-31 | 1,976 | $67.70 | $133.8K | 49,869 | SEC↗ |
| Manning Meredith | Chief Commercial Officer | S Sale | 2025-03-27 | 2025-03-31 | 2,599 | $68.79 | $178.8K | 47,270 | SEC↗ |
| Manning Meredith | Chief Commercial Officer | S Sale | 2025-03-27 | 2025-03-31 | 1,505 | $69.84 | $105.1K | 45,765 | SEC↗ |
| Manning Meredith | Chief Commercial Officer | S Sale | 2025-03-27 | 2025-03-31 | 155 | $70.73 | $11.0K | 45,610 | SEC↗ |
| Manning Meredith | Chief Commercial Officer | S Sale | 2025-03-27 | 2025-03-31 | 225 | $71.74 | $16.1K | 45,385 | SEC↗ |
| Manning Meredith | Chief Commercial Officer | S Sale | 2025-03-27 | 2025-03-31 | 34 | $72.64 | $2.5K | 45,351 | SEC↗ |
| Manning Meredith | Chief Commercial Officer | M Exercise | 2025-03-27 | 2025-03-31 | 37,000 | $46.31 | $1.71M | 82,351 | SEC↗ |
| Yen Kristen | SEE REMARKS | S Sale | 2025-03-27 | 2025-03-31 | 5,239 | $67.70 | $354.7K | 73,116 | SEC↗ |
| Yen Kristen | SEE REMARKS | S Sale | 2025-03-27 | 2025-03-31 | 50,156 | $66.00 | $3.31M | 51,618 | SEC↗ |
| Yen Kristen | SEE REMARKS | S Sale | 2025-03-27 | 2025-03-31 | 411 | $70.73 | $29.1K | 61,824 | SEC↗ |
| Yen Kristen | SEE REMARKS | S Sale | 2025-03-27 | 2025-03-31 | 597 | $71.74 | $42.8K | 61,227 | SEC↗ |
| Yen Kristen | SEE REMARKS | S Sale | 2025-03-27 | 2025-03-31 | 3,990 | $69.84 | $278.7K | 62,235 | SEC↗ |
| Yen Kristen | SEE REMARKS | S Sale | 2025-03-27 | 2025-03-31 | 6,891 | $68.79 | $474.0K | 66,225 | SEC↗ |
| Yen Kristen | SEE REMARKS | S Sale | 2025-03-27 | 2025-03-31 | 23,475 | $66.95 | $1.57M | 28,143 | SEC↗ |
| Yen Kristen | SEE REMARKS | S Sale | 2025-03-27 | 2025-03-31 | 2,881 | $66.79 | $192.4K | 78,355 | SEC↗ |
| Yen Kristen | SEE REMARKS | S Sale | 2025-03-27 | 2025-03-31 | 1,769 | $65.97 | $116.7K | 81,236 | SEC↗ |
| Yen Kristen | SEE REMARKS | M Exercise | 2025-03-27 | 2025-03-31 | 4,888 | $5.10 | $24.9K | 66,024 | SEC↗ |
| Yen Kristen | SEE REMARKS | S Sale | 2025-03-27 | 2025-03-31 | 91 | $72.64 | $6.6K | 61,136 | SEC↗ |
| Yen Kristen | SEE REMARKS | M Exercise | 2025-03-27 | 2025-03-31 | 3,750 | $2.41 | $9.0K | 69,774 | SEC↗ |
| Yen Kristen | SEE REMARKS | M Exercise | 2025-03-27 | 2025-03-31 | 32,000 | $5.25 | $168.0K | 101,774 | SEC↗ |
| Vivo Opportunity Fund Holdings | 10% Owner | S Sale | 2025-03-26 | 2025-03-28 | 400,000 | $65.80 | $26.32M | 5,891,851 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | A Award deriv | 2025-01-21 | 2025-01-23 | 115,600 | — | $0 | 115,600 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | A Award deriv | 2025-01-21 | 2025-01-23 | 13,800 | — | $0 | 13,800 | SEC↗ |
| Huang Michael F. | Sr. VP of Clinical Developme | A Award deriv | 2025-01-21 | 2025-01-23 | 13,800 | — | $0 | 13,800 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | A Award deriv | 2025-01-21 | 2025-01-23 | 31,000 | — | $0 | 31,000 | SEC↗ |
| Manning Meredith | Chief Commercial Officer | A Award deriv | 2025-01-21 | 2025-01-23 | 29,200 | — | $0 | 29,200 | SEC↗ |
| Yen Kristen | SEE REMARKS | A Award deriv | 2025-01-21 | 2025-01-23 | 13,800 | — | $0 | 13,800 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | A Award | 2025-01-21 | 2025-01-23 | 53,900 | — | $0 | 752,362 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | A Award | 2025-01-21 | 2025-01-23 | 6,400 | — | $0 | 112,302 | SEC↗ |
| Huang Michael F. | Sr. VP of Clinical Developme | A Award | 2025-01-21 | 2025-01-23 | 6,400 | — | $0 | 41,400 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | A Award | 2025-01-21 | 2025-01-23 | 14,500 | — | $0 | 125,798 | SEC↗ |
| Manning Meredith | Chief Commercial Officer | A Award | 2025-01-21 | 2025-01-23 | 13,600 | — | $0 | 53,600 | SEC↗ |
| Yen Kristen | SEE REMARKS | A Award | 2025-01-21 | 2025-01-23 | 6,400 | — | $0 | 83,005 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | S Sale | 2025-01-03 | 2025-01-06 | 10,154 | $46.18 | $468.9K | 698,462 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2025-01-03 | 2025-01-06 | 1,459 | $46.18 | $67.4K | 105,902 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | S Sale | 2025-01-03 | 2025-01-06 | 3,791 | $46.18 | $175.1K | 111,298 | SEC↗ |
| Yen Kristen | SEE REMARKS | S Sale | 2025-01-03 | 2025-01-06 | 2,340 | $46.18 | $108.1K | 76,605 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | S Sale | 2025-01-02 | 2025-01-06 | 10,077 | $45.37 | $457.2K | 709,476 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | S Sale | 2025-01-02 | 2025-01-06 | 860 | $45.92 | $39.5K | 708,616 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2025-01-02 | 2025-01-06 | 1,447 | $45.37 | $65.7K | 107,485 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2025-01-02 | 2025-01-06 | 124 | $45.92 | $5.7K | 107,361 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | S Sale | 2025-01-02 | 2025-01-06 | 3,762 | $45.37 | $170.7K | 115,410 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | S Sale | 2025-01-02 | 2025-01-06 | 321 | $45.92 | $14.7K | 115,089 | SEC↗ |
| Yen Kristen | SEE REMARKS | S Sale | 2025-01-02 | 2025-01-06 | 198 | $45.92 | $9.1K | 78,945 | SEC↗ |
| Yen Kristen | SEE REMARKS | S Sale | 2025-01-02 | 2025-01-06 | 2,322 | $45.37 | $105.3K | 79,143 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | S Sale | 2024-10-01 | 2024-10-03 | 19,413 | $49.34 | $957.8K | 721,773 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | S Sale | 2024-10-01 | 2024-10-03 | 2,220 | $50.25 | $111.6K | 719,553 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2024-10-01 | 2024-10-03 | 2,789 | $49.34 | $137.6K | 109,251 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2024-10-01 | 2024-10-03 | 319 | $50.25 | $16.0K | 108,932 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | S Sale | 2024-10-01 | 2024-10-03 | 7,248 | $49.34 | $357.6K | 120,001 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | S Sale | 2024-10-01 | 2024-10-03 | 829 | $50.25 | $41.7K | 119,172 | SEC↗ |
| Yen Kristen | SEE REMARKS | S Sale | 2024-10-01 | 2024-10-03 | 319 | $50.25 | $16.0K | 81,465 | SEC↗ |
| Yen Kristen | SEE REMARKS | S Sale | 2024-10-01 | 2024-10-03 | 2,789 | $49.34 | $137.6K | 81,784 | SEC↗ |
| Vivo Opportunity, LLC | 10% Owner | S Sale | 2024-08-29 | 2024-08-29 | 100,000 | $47.22 | $4.72M | 6,291,851 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | S Sale | 2024-08-29 | 2024-08-30 | 47,551 | $47.16 | $2.24M | 752,026 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | S Sale | 2024-08-29 | 2024-08-30 | 10,840 | $47.83 | $518.5K | 741,186 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2024-08-29 | 2024-08-30 | 4,426 | $47.16 | $208.7K | 113,049 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2024-08-29 | 2024-08-30 | 1,009 | $47.83 | $48.3K | 112,040 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | S Sale | 2024-08-29 | 2024-08-30 | 1,275 | $47.83 | $61.0K | 127,249 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | S Sale | 2024-08-29 | 2024-08-30 | 5,595 | $47.16 | $263.9K | 128,524 | SEC↗ |
| Yen Kristen | SEE REMARKS | S Sale | 2024-08-29 | 2024-08-30 | 4,426 | $47.16 | $208.7K | 85,582 | SEC↗ |
| Yen Kristen | SEE REMARKS | S Sale | 2024-08-29 | 2024-08-30 | 1,009 | $47.83 | $48.3K | 84,573 | SEC↗ |
| Vivo Opportunity, LLC | 10% Owner | S Sale | 2024-08-28 | 2024-08-29 | 425,000 | $47.35 | $20.12M | 6,391,851 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | S Sale | 2024-08-28 | 2024-08-30 | 30,262 | $47.19 | $1.43M | 825,928 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | S Sale | 2024-08-28 | 2024-08-30 | 26,351 | $48.03 | $1.27M | 799,577 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2024-08-28 | 2024-08-30 | 2,453 | $48.03 | $117.8K | 117,475 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2024-08-28 | 2024-08-30 | 2,817 | $47.19 | $132.9K | 119,928 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | S Sale | 2024-08-28 | 2024-08-30 | 3,100 | $48.03 | $148.9K | 134,119 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | S Sale | 2024-08-28 | 2024-08-30 | 3,561 | $47.19 | $168.0K | 137,219 | SEC↗ |
| Yen Kristen | SEE REMARKS | S Sale | 2024-08-28 | 2024-08-30 | 2,453 | $48.03 | $117.8K | 90,008 | SEC↗ |
| Yen Kristen | SEE REMARKS | S Sale | 2024-08-28 | 2024-08-30 | 2,817 | $47.19 | $132.9K | 92,461 | SEC↗ |
| Vivo Opportunity, LLC | 10% Owner | S Sale | 2024-08-27 | 2024-08-29 | 500,000 | $48.73 | $24.36M | 6,816,851 | SEC↗ |
| Bir Dawn Carter | Director | A Award | 2024-08-15 | 2024-08-16 | 13,000 | — | $0 | 13,000 | SEC↗ |
| Urbanski Raymond W. | CHIEF DEVELOPMENT OFFICER | A Award deriv | 2024-08-13 | 2024-08-23 | 145,000 | — | $0 | 145,000 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | S Sale | 2024-08-06 | 2024-08-07 | 6,789 | $43.64 | $296.3K | 918,532 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | S Sale | 2024-08-06 | 2024-08-07 | 22,937 | $45.25 | $1.04M | 895,595 | SEC↗ |
| Anish Bhatnagar | CHIEF EXECUTIVE OFFICER | S Sale | 2024-08-06 | 2024-08-07 | 39,405 | $45.89 | $1.81M | 856,190 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2024-08-06 | 2024-08-07 | 587 | $43.64 | $25.6K | 128,135 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2024-08-06 | 2024-08-07 | 3,407 | $45.89 | $156.3K | 122,745 | SEC↗ |
| Hirano Patricia C | SEE REMARKS | S Sale | 2024-08-06 | 2024-08-07 | 1,983 | $45.25 | $89.7K | 126,152 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | S Sale | 2024-08-06 | 2024-08-07 | 2,699 | $45.25 | $122.1K | 145,416 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | S Sale | 2024-08-06 | 2024-08-07 | 4,636 | $45.89 | $212.7K | 140,780 | SEC↗ |
| Mackaness James H | CHIEF FINANCIAL OFFICER | S Sale | 2024-08-06 | 2024-08-07 | 799 | $43.64 | $34.9K | 148,115 | SEC↗ |
| Yen Kristen | SEE REMARKS | S Sale | 2024-08-06 | 2024-08-07 | 585 | $43.64 | $25.5K | 100,650 | SEC↗ |
| Yen Kristen | SEE REMARKS | S Sale | 2024-08-06 | 2024-08-07 | 1,976 | $45.25 | $89.4K | 98,674 | SEC↗ |