SPRO

Spero Therapeutics, Inc.CIK 1701108 ☆ Sign in to watch Congress trades

Open-mkt buys · 90d

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0 trades · 0 insiders

Open-mkt sales · 90d

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0 trades · 0 insiders

Net · 90d

Insiders on file

AI insights for SPRO PRO

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AI insights for SPRO

Insider sentiment score with a plain-English explanation, conviction score on every buy, and how the stock performed 30 and 90 days after past insider buys.

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Daily buy vs sell · 90 days

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Insiders

Insider	Role	Trades	Bought	Sold	Last trade
Zack Debra	Chief Medical Officer	4	$0	$0	2026-08-03
Tregoning Kathleen	Director	10	$0	$0	2026-06-23
Smith Cynthia	Director	11	$0	$0	2026-06-23
Jackson Scott Thomas	Director	9	$0	$0	2026-06-23
VINK PATRICK V.J.J.	Director	14	$0	$0	2026-06-23
Deshpande Milind	Director	12	$0	$0	2026-06-23
Pottage John C Jr	Director	10	$0	$0	2026-06-23
THOMAS FRANK E	Director	13	$0	$0	2026-06-23
Rajavelu Esther	See Remarks	15	$0	$476.0K	2026-05-04
Keutzer Timothy	Chief Operating Officer	22	$0	$246.4K	2026-02-06
Mahadevia Ankit	See Remarks	69	$0	$1.04M	2025-08-28
Shukla Sath	Chief Financial Officer	20	$0	$305.7K	2025-02-05
HAMED KAMAL	Chief Medical Officer	6	$0	$88.6K	2024-02-02
JOSEPH TAMARA L	Chief Legal Officer	9	$0	$51.0K	2024-02-02
Aquilo Capital Management, LLC	10% Owner	15	$8.77M	$4.34M	2022-09-22
Aquilo Capital, L.P.	10% Owner	25	$13.64M	$11.07M	2022-04-26
Melnick David A.	Chief Medical Officer	7	$0	$0	2022-02-01
Larkin Cristina	Chief Operating Officer	14	$21.0K	$298.0K	2022-02-01
FORMELA JEAN FRANCOIS	Director	16	$6.00M	$0	2021-08-17
Sendek Joel	Chief Financial Officer	8	$70.0K	$35.0K	2019-01-02
Parr Thomas R JR	Chief Scientific Officer	2	$0	$0	2019-01-02
GLAXOSMITHKLINE PLC	10% Owner	10	$7.00M	$0	2018-07-17
Breum Casper	Director	8	$3.00M	$0	2018-06-05
SOUTHWELL DAVID P	Director	2	$0	$0	2018-06-05
Goyal Vikas	Director	9	$6.00M	$0	2017-11-06
Wirtheim Stanley P	Chief Financial Officer	3	$0	$0	2015-03-05
Fish Joseph R	EVP & Chief Technology Officer	3	$0	$0	2015-03-05
Greene Allen S	Chairman of the Board and CEO	7	$32.0K	$0	2015-03-05
Fingerhut Jack	President	4	$4.8K	$0	2015-03-05
STANLEY LEONARD J	Director	1	$0	$0	2013-02-05
Martin Lager H	Director	1	$0	$0	2013-02-05
GORMAN JOHN J	Director	2	$8.7K	$0	2013-02-05
Ben-Dov Zohar	10% Owner	1	$27.0K	$0	2012-12-28

Trade history

Insider	Role	Code	Trade	Filed	Shares	Price	Value	Owned after
Zack Debra	Chief Medical Officer	A Award deriv	2026-08-03	2026-08-06	324,675	—	$0	324,675	SEC↗
Zack Debra	Chief Medical Officer	A Award	2026-08-03	2026-08-06	162,311	—	$0	162,311	SEC↗
Zack Debra	Chief Medical Officer	A Award deriv	2026-08-03	2026-08-06	324,675	—	$0	324,675	SEC↗
Zack Debra	Chief Medical Officer	A Award	2026-08-03	2026-08-06	162,311	—	$0	162,311	SEC↗
Pottage John C Jr	Director	A Award deriv	2026-06-23	2026-06-25	20,000	—	$0	20,000	SEC↗
Jackson Scott Thomas	Director	A Award deriv	2026-06-23	2026-06-25	20,000	—	$0	20,000	SEC↗
THOMAS FRANK E	Director	A Award deriv	2026-06-23	2026-06-25	20,000	—	$0	20,000	SEC↗
VINK PATRICK V.J.J.	Director	A Award deriv	2026-06-23	2026-06-25	20,000	—	$0	20,000	SEC↗
Smith Cynthia	Director	A Award deriv	2026-06-23	2026-06-25	20,000	—	$0	20,000	SEC↗
Tregoning Kathleen	Director	A Award deriv	2026-06-23	2026-06-25	20,000	—	$0	20,000	SEC↗
Deshpande Milind	Director	A Award deriv	2026-06-23	2026-06-25	20,000	—	$0	20,000	SEC↗
Pottage John C Jr	Director	A Award	2026-06-23	2026-06-25	10,000	—	$0	85,000	SEC↗
Jackson Scott Thomas	Director	A Award	2026-06-23	2026-06-25	10,000	—	$0	85,000	SEC↗
THOMAS FRANK E	Director	A Award	2026-06-23	2026-06-25	10,000	—	$0	85,000	SEC↗
VINK PATRICK V.J.J.	Director	A Award	2026-06-23	2026-06-25	10,000	—	$0	85,000	SEC↗
Smith Cynthia	Director	A Award	2026-06-23	2026-06-25	10,000	—	$0	85,000	SEC↗
Tregoning Kathleen	Director	A Award	2026-06-23	2026-06-25	10,000	—	$0	85,000	SEC↗
Deshpande Milind	Director	A Award	2026-06-23	2026-06-25	10,000	—	$0	101,454	SEC↗
Rajavelu Esther	See Remarks	S Sale	2026-05-04	2026-05-06	25,240	$2.51	$63.4K	986,851	SEC↗
Keutzer Timothy	Chief Operating Officer	S Sale	2026-02-06	2026-02-09	18,652	$2.36	$44.0K	742,506	SEC↗
Rajavelu Esther	See Remarks	S Sale	2026-02-06	2026-02-09	50,816	$2.36	$119.9K	1,012,091	SEC↗
Rajavelu Esther	See Remarks	S Sale	2026-02-06	2026-02-09	37,101	$2.36	$87.6K	1,062,907	SEC↗
Keutzer Timothy	Chief Operating Officer	S Sale	2026-02-04	2026-02-05	3,471	$2.24	$7.8K	761,158	SEC↗
Keutzer Timothy	Chief Operating Officer	S Sale	2026-02-03	2026-02-05	24,224	$2.14	$51.8K	764,629	SEC↗
Rajavelu Esther	See Remarks	A Award deriv	2026-02-02	2026-02-04	498,000	—	$0	498,000	SEC↗
Keutzer Timothy	Chief Operating Officer	A Award deriv	2026-02-02	2026-02-05	137,000	—	$0	137,000	SEC↗
Rajavelu Esther	See Remarks	A Award	2026-02-02	2026-02-04	249,000	—	$0	1,118,450	SEC↗
Rajavelu Esther	See Remarks	S Sale	2026-02-02	2026-02-04	18,442	$2.20	$40.6K	1,100,008	SEC↗
Keutzer Timothy	Chief Operating Officer	A Award	2026-02-02	2026-02-05	68,000	—	$0	807,744	SEC↗
Keutzer Timothy	Chief Operating Officer	S Sale	2026-02-02	2026-02-05	18,891	$2.20	$41.6K	788,853	SEC↗
Rajavelu Esther	See Remarks	S Sale	2025-11-07	2025-11-12	40,270	$2.37	$95.4K	869,450	SEC↗
Keutzer Timothy	Chief Operating Officer	S Sale	2025-08-28	2025-09-03	1,695	$1.97	$3.3K	739,744	SEC↗
Mahadevia Ankit	Director	S Sale	2025-08-28	2025-09-03	6,572	$1.97	$12.9K	703,294	SEC↗
Tregoning Kathleen	Director	A Award	2025-06-12	2025-06-16	20,000	—	$0	75,000	SEC↗
THOMAS FRANK E	Director	A Award	2025-06-12	2025-06-16	20,000	—	$0	75,000	SEC↗
Smith Cynthia	Director	A Award	2025-06-12	2025-06-16	20,000	—	$0	75,000	SEC↗
Pottage John C Jr	Director	A Award	2025-06-12	2025-06-16	20,000	—	$0	75,000	SEC↗
VINK PATRICK V.J.J.	Director	A Award	2025-06-12	2025-06-16	20,000	—	$0	75,000	SEC↗
Jackson Scott Thomas	Director	A Award	2025-06-12	2025-06-16	20,000	—	$0	75,000	SEC↗
Deshpande Milind	Director	A Award	2025-06-12	2025-06-16	20,000	—	$0	91,454	SEC↗
Mahadevia Ankit	Director	A Award	2025-06-12	2025-06-16	20,000	—	$0	709,866	SEC↗
Rajavelu Esther	See Remarks	A Award	2025-05-02	2025-05-06	185,000	—	$0	909,720	SEC↗
Mahadevia Ankit	Director	S Sale	2025-02-05	2025-02-05	55,260	$0.78	$43.1K	689,866	SEC↗
Mahadevia Ankit	Director	S Sale	2025-02-05	2025-02-05	13,959	$0.78	$10.9K	745,126	SEC↗
Shukla Sath	CEO & President	S Sale	2025-02-05	2025-02-05	6,139	$0.78	$4.8K	1,886,077	SEC↗
Shukla Sath	CEO & President	S Sale	2025-02-05	2025-02-05	42,786	$0.78	$33.4K	1,843,291	SEC↗
Shukla Sath	CEO & President	S Sale	2025-02-05	2025-02-05	106,408	$0.78	$83.0K	1,736,883	SEC↗
Rajavelu Esther	CFO & CBO	S Sale	2025-02-05	2025-02-05	20,689	$0.78	$16.1K	724,720	SEC↗
Keutzer Timothy	Chief Operating Officer	S Sale	2025-02-05	2025-02-05	3,974	$0.78	$3.1K	794,002	SEC↗
Keutzer Timothy	Chief Operating Officer	S Sale	2025-02-05	2025-02-05	27,643	$0.78	$21.6K	766,359	SEC↗
Keutzer Timothy	Chief Operating Officer	S Sale	2025-02-05	2025-02-05	24,920	$0.78	$19.4K	741,439	SEC↗
Shukla Sath	CEO & President	A Award	2025-02-03	2025-02-05	751,407	—	$0	1,892,216	SEC↗
Rajavelu Esther	CFO & CBO	A Award	2025-02-03	2025-02-05	266,139	—	$0	645,409	SEC↗
Rajavelu Esther	CFO & CBO	A Award	2025-02-03	2025-02-05	100,000	—	$0	745,409	SEC↗
Keutzer Timothy	Chief Operating Officer	A Award	2025-02-03	2025-02-05	266,139	—	$0	797,976	SEC↗
Rajavelu Esther	CFO & CBO	S Sale	2024-11-08	2024-11-12	17,245	$1.30	$22.4K	379,270	SEC↗
Rajavelu Esther	CFO & CBO	S Sale	2024-11-07	2024-11-12	23,351	$1.31	$30.6K	396,515	SEC↗
Shukla Sath	CEO & President	S Sale	2024-08-27	2024-08-29	2,757	$1.35	$3.7K	1,140,809	SEC↗
Keutzer Timothy	Chief Operating Officer	S Sale	2024-08-27	2024-08-29	2,213	$1.35	$3.0K	531,837	SEC↗
Mahadevia Ankit	Director	S Sale	2024-08-27	2024-08-29	5,912	$1.35	$8.0K	759,085	SEC↗
Shukla Sath	CEO and President	S Sale	2024-08-05	2024-08-06	17,641	$1.31	$23.1K	1,143,566	SEC↗
Shukla Sath	CEO and President	S Sale	2024-08-02	2024-08-06	14,800	$1.32	$19.5K	1,161,207	SEC↗
Pottage John C Jr	Director	A Award	2024-05-29	2024-05-30	20,000	—	$0	55,000	SEC↗
THOMAS FRANK E	Director	A Award	2024-05-29	2024-05-30	20,000	—	$0	55,000	SEC↗
Smith Cynthia	Director	A Award	2024-05-29	2024-05-30	20,000	—	$0	55,000	SEC↗
VINK PATRICK V.J.J.	Director	A Award	2024-05-29	2024-05-30	20,000	—	$0	55,000	SEC↗
Tregoning Kathleen	Director	A Award	2024-05-29	2024-05-30	20,000	—	$0	55,000	SEC↗
Mahadevia Ankit	Director	A Award	2024-05-29	2024-05-30	20,000	—	$0	764,997	SEC↗
Jackson Scott Thomas	Director	A Award	2024-05-29	2024-05-30	20,000	—	$0	55,000	SEC↗
Deshpande Milind	Director	A Award	2024-05-29	2024-05-30	20,000	—	$0	71,454	SEC↗
Shukla Sath	CEO and President	S Sale	2024-02-05	2024-02-05	45,093	$1.45	$65.4K	1,176,007	SEC↗
Shukla Sath	CEO and President	S Sale	2024-02-02	2024-02-05	30,901	$1.37	$42.3K	1,221,100	SEC↗
HAMED KAMAL	Chief Medical Officer	S Sale	2024-02-02	2024-02-05	28,075	$1.37	$38.5K	788,117	SEC↗
JOSEPH TAMARA L	Chief Legal Officer	S Sale	2024-02-02	2024-02-05	30,906	$1.37	$42.3K	531,615	SEC↗
Mahadevia Ankit	Director	S Sale	2024-02-02	2024-02-05	63,795	$1.37	$87.4K	744,997	SEC↗
Keutzer Timothy	Chief Operating Officer	S Sale	2024-02-02	2024-02-05	30,971	$1.36	$42.1K	534,050	SEC↗
Shukla Sath	CEO and President	A Award	2024-02-01	2024-02-05	679,501	—	$0	1,252,001	SEC↗
Rajavelu Esther	See Remarks	A Award	2024-02-01	2024-02-05	119,866	—	$0	419,866	SEC↗
HAMED KAMAL	Chief Medical Officer	A Award	2024-02-01	2024-02-05	239,731	—	$0	816,192	SEC↗
JOSEPH TAMARA L	Chief Legal Officer	A Award	2024-02-01	2024-02-05	239,731	—	$0	562,521	SEC↗
Keutzer Timothy	Chief Operating Officer	A Award	2024-02-01	2024-02-05	239,731	—	$0	565,021	SEC↗
Tregoning Kathleen	Director	A Award deriv	2024-01-02	2024-01-04	35,604	$1.12	$39.9K	35,604	SEC↗
Rajavelu Esther	See Remarks	A Award	2023-11-13	2023-11-15	300,000	—	$0	300,000	SEC↗
Mahadevia Ankit	Director	A Award	2023-10-05	2023-10-10	20,000	—	$0	808,792	SEC↗
Jackson Scott Thomas	Director	A Award	2023-10-05	2023-10-10	20,000	—	$0	35,000	SEC↗
VINK PATRICK V.J.J.	Director	A Award	2023-10-05	2023-10-10	20,000	—	$0	35,000	SEC↗
Tregoning Kathleen	Director	A Award	2023-10-05	2023-10-10	20,000	—	$0	35,000	SEC↗
Deshpande Milind	Director	A Award	2023-10-05	2023-10-10	20,000	—	$0	51,454	SEC↗
THOMAS FRANK E	Director	A Award	2023-10-05	2023-10-10	20,000	—	$0	35,000	SEC↗
Smith Cynthia	Director	A Award	2023-10-05	2023-10-10	20,000	—	$0	35,000	SEC↗
Pottage John C Jr	Director	A Award	2023-10-05	2023-10-10	20,000	—	$0	35,000	SEC↗
HAMED KAMAL	Chief Medical Officer	S Sale	2023-09-13	2023-09-15	39,496	$1.27	$50.2K	576,461	SEC↗
Shukla Sath	CEO and President	S Sale	2023-08-29	2023-08-30	4,163	$1.30	$5.4K	572,500	SEC↗
Shukla Sath	CEO and President	S Sale	2023-08-28	2023-08-30	1,854	$1.26	$2.3K	576,663	SEC↗
Mahadevia Ankit	Director	S Sale	2023-08-28	2023-08-30	9,040	$1.26	$11.4K	788,792	SEC↗
JOSEPH TAMARA L	Chief Legal Officer	S Sale	2023-08-28	2023-08-30	1,854	$1.26	$2.3K	322,790	SEC↗
Keutzer Timothy	Chief Development Officer	S Sale	2023-08-28	2023-08-30	1,854	$1.26	$2.3K	325,290	SEC↗
Shukla Sath	CEO and President	A Award	2023-08-01	2023-08-03	266,000	—	$0	578,517	SEC↗
HAMED KAMAL	Chief Medical Officer	A Award	2023-06-12	2023-06-14	140,000	—	$0	615,957	SEC↗
Mahadevia Ankit	CEO and President	S Sale	2023-02-03	2023-02-06	12,286	$1.81	$22.2K	797,832	SEC↗
Shukla Sath	Chief Financial Officer	S Sale	2023-02-02	2023-02-03	9,504	$1.83	$17.4K	312,517	SEC↗
JOSEPH TAMARA L	Chief Legal Officer	S Sale	2023-02-02	2023-02-03	3,394	$1.86	$6.3K	324,644	SEC↗
Keutzer Timothy	Chief Operating Officer	S Sale	2023-02-02	2023-02-03	3,394	$1.86	$6.3K	327,144	SEC↗
Mahadevia Ankit	CEO and President	A Award	2023-02-01	2023-02-03	531,914	—	$0	810,118	SEC↗
HAMED KAMAL	Chief Medical Officer	A Award	2023-02-01	2023-02-03	265,957	—	$0	475,957	SEC↗
Shukla Sath	Chief Financial Officer	A Award	2023-02-01	2023-02-03	265,957	—	$0	322,021	SEC↗
JOSEPH TAMARA L	Chief Legal Officer	A Award	2023-02-01	2023-02-03	265,957	—	$0	328,038	SEC↗
Keutzer Timothy	Chief Operating Officer	A Award	2023-02-01	2023-02-03	265,957	—	$0	330,538	SEC↗
VINK PATRICK V.J.J.	Director	A Award deriv	2023-01-03	2023-01-05	15,471	$1.29	$20.0K	15,471	SEC↗
Tregoning Kathleen	Director	A Award deriv	2023-01-03	2023-01-05	30,943	$1.29	$39.9K	30,943	SEC↗
Aquilo Capital Management, LLC	10% Owner	S Sale	2022-09-22	2022-09-26	1,335,512	$2.25	$3.00M	3,985,719	SEC↗
Aquilo Capital Management, LLC	10% Owner	S Sale	2022-09-22	2022-09-26	566,284	$2.25	$1.27M	3,419,435	SEC↗
VINK PATRICK V.J.J.	Director	A Award	2022-09-15	2022-09-19	15,000	—	$0	15,000	SEC↗
Tregoning Kathleen	Director	A Award	2022-09-15	2022-09-19	15,000	—	$0	15,000	SEC↗
THOMAS FRANK E	Director	A Award	2022-09-15	2022-09-19	15,000	—	$0	15,000	SEC↗
Smith Cynthia	Director	A Award	2022-09-15	2022-09-19	15,000	—	$0	15,000	SEC↗
Pottage John C Jr	Director	A Award	2022-09-15	2022-09-19	15,000	—	$0	15,000	SEC↗
Deshpande Milind	Director	A Award	2022-09-15	2022-09-19	15,000	—	$0	31,454	SEC↗
Jackson Scott Thomas	Director	A Award	2022-09-15	2022-09-19	15,000	—	$0	15,000	SEC↗
HAMED KAMAL	Chief Medical Officer	A Award	2022-09-12	2022-09-14	210,000	—	$0	210,000	SEC↗
Shukla Sath	Chief Financial Officer	S Sale	2022-08-29	2022-08-30	6,017	$0.89	$5.4K	56,064	SEC↗
Aquilo Capital, L.P.	10% Owner	P Buy	2022-04-26	2022-04-28	39,727	$5.24	$208.2K	5,321,231	SEC↗
Aquilo Capital Management, LLC	10% Owner	P Buy	2022-03-30	2022-03-31	33,115	$8.79	$291.1K	5,264,619	SEC↗
Aquilo Capital Management, LLC	10% Owner	P Buy	2022-03-30	2022-03-31	16,885	$8.79	$148.4K	5,281,504	SEC↗
Aquilo Capital, L.P.	10% Owner	P Buy	2022-03-14	2022-03-16	8,006	$7.63	$61.1K	5,231,504	SEC↗
Aquilo Capital, L.P.	10% Owner	P Buy	2022-03-14	2022-03-16	15,702	$7.63	$119.8K	5,223,498	SEC↗
Aquilo Capital, L.P.	10% Owner	P Buy	2022-02-28	2022-03-02	29,729	$9.53	$283.3K	5,192,692	SEC↗
Aquilo Capital, L.P.	10% Owner	P Buy	2022-02-28	2022-03-02	15,104	$9.53	$143.9K	5,207,796	SEC↗
Aquilo Capital Management, LLC	10% Owner	P Buy	2022-02-18	2022-02-23	14,828	$9.24	$137.0K	5,162,963	SEC↗
JOSEPH TAMARA L	Chief Legal Officer	A Award deriv	2022-02-01	2022-02-03	53,190	—	$0	53,190	SEC↗
Keutzer Timothy	Chief Development Officer	A Award deriv	2022-02-01	2022-02-03	53,190	—	$0	53,190	SEC↗
Mahadevia Ankit	CEO and President	A Award deriv	2022-02-01	2022-02-03	187,730	—	$0	187,730	SEC↗
Larkin Cristina	Chief Operating Officer	A Award deriv	2022-02-01	2022-02-03	53,190	—	$0	53,190	SEC↗
Shukla Sath	Chief Financial Officer	A Award deriv	2022-02-01	2022-02-03	53,190	—	$0	53,190	SEC↗
Melnick David A.	Chief Medical Officer	A Award deriv	2022-02-01	2022-02-03	53,190	—	$0	53,190	SEC↗
JOSEPH TAMARA L	Chief Legal Officer	A Award	2022-02-01	2022-02-03	38,014	—	$0	62,081	SEC↗
Keutzer Timothy	Chief Development Officer	A Award	2022-02-01	2022-02-03	38,014	—	$0	64,581	SEC↗
Mahadevia Ankit	CEO and President	A Award	2022-02-01	2022-02-03	134,168	—	$0	278,204	SEC↗
Larkin Cristina	Chief Operating Officer	A Award	2022-02-01	2022-02-03	38,014	—	$0	63,581	SEC↗
Shukla Sath	Chief Financial Officer	A Award	2022-02-01	2022-02-03	38,014	—	$0	62,081	SEC↗
Melnick David A.	Chief Medical Officer	A Award	2022-02-01	2022-02-03	38,014	—	$0	62,081	SEC↗
Aquilo Capital Management, LLC	10% Owner	P Buy	2022-01-31	2022-02-01	125,000	$11.59	$1.45M	5,148,135	SEC↗
Aquilo Capital, L.P.	10% Owner	P Buy	2022-01-24	2022-01-26	1,599	$10.89	$17.4K	5,023,135	SEC↗
Aquilo Capital Management, LLC	10% Owner	P Buy	2022-01-18	2022-01-20	48,488	$12.41	$601.7K	5,021,536	SEC↗
Aquilo Capital Management, LLC	10% Owner	P Buy	2022-01-10	2022-01-12	8,867	$12.93	$114.7K	4,973,048	SEC↗
VINK PATRICK V.J.J.	Director	A Award deriv	2022-01-05	2022-01-07	2,214	$9.03	$20.0K	2,214	SEC↗
THOMAS FRANK E	Director	A Award deriv	2022-01-05	2022-01-07	2,214	$9.03	$20.0K	2,214	SEC↗
Tregoning Kathleen	Director	A Award deriv	2022-01-05	2022-01-07	4,428	$9.03	$40.0K	4,428	SEC↗
Aquilo Capital Management, LLC	10% Owner	P Buy	2021-12-31	2022-01-03	125,000	$15.75	$1.97M	4,964,181	SEC↗
Aquilo Capital Management, LLC	10% Owner	P Buy	2021-12-30	2022-01-03	50,000	$15.77	$788.5K	4,839,181	SEC↗
Aquilo Capital Management, LLC	10% Owner	P Buy	2021-12-29	2022-01-03	75,493	$14.64	$1.11M	4,789,181	SEC↗
Mahadevia Ankit	CEO and President	M Exercise deriv	2021-12-27	2021-12-29	8,000	—	$0	486,809	SEC↗
Mahadevia Ankit	CEO and President	M Exercise	2021-12-27	2021-12-29	8,000	$5.90	$47.2K	152,036	SEC↗
Mahadevia Ankit	CEO and President	S Sale	2021-12-27	2021-12-29	8,000	$14.58	$116.6K	144,036	SEC↗
Tregoning Kathleen	Director	A Award deriv	2021-11-11	2021-11-12	15,000	—	$0	15,000	SEC↗
Aquilo Capital, L.P.	10% Owner	P Buy	2021-10-29	2021-11-02	150,000	$17.53	$2.63M	4,713,688	SEC↗
Aquilo Capital, L.P.	10% Owner	P Buy	2021-09-30	2021-10-04	134,543	$18.65	$2.51M	4,563,688	SEC↗
Aquilo Capital, L.P.	10% Owner	P Buy	2021-09-14	2021-09-15	2,156	$18.49	$39.9K	4,429,145	SEC↗
Aquilo Capital, L.P.	10% Owner	P Buy	2021-09-13	2021-09-15	44,210	$18.56	$820.5K	4,426,989	SEC↗
Aquilo Capital Management, LLC	10% Owner	P Buy	2021-09-09	2021-09-10	24,749	$18.50	$457.9K	4,382,779	SEC↗
Aquilo Capital Management, LLC	10% Owner	P Buy	2021-08-31	2021-09-01	48,645	$18.93	$920.8K	4,358,030	SEC↗
Aquilo Capital Management, LLC	10% Owner	P Buy	2021-08-30	2021-09-01	44,042	$17.87	$787.0K	4,309,385	SEC↗
Aquilo Capital, L.P.	10% Owner	P Buy	2021-08-27	2021-08-27	13,957	$16.88	$235.6K	4,265,343	SEC↗
Aquilo Capital, L.P.	10% Owner	P Buy	2021-08-26	2021-08-27	22,982	$16.55	$380.4K	4,251,386	SEC↗
Shukla Sath	Chief Financial Officer	A Award	2021-08-26	2021-08-30	24,067	—	$0	24,067	SEC↗
Keutzer Timothy	Chief Development Officer	A Award	2021-08-26	2021-08-30	24,067	—	$0	26,567	SEC↗
JOSEPH TAMARA L	Chief Legal Officer	A Award	2021-08-26	2021-08-30	24,067	—	$0	24,067	SEC↗
Larkin Cristina	Chief Operating Officer	A Award	2021-08-26	2021-08-30	24,067	—	$0	25,567	SEC↗
Mahadevia Ankit	CEO and President	A Award	2021-08-26	2021-08-30	78,219	—	$0	144,036	SEC↗
Melnick David A.	Chief Medical Officer	A Award	2021-08-26	2021-08-30	24,067	—	$0	24,067	SEC↗
Aquilo Capital, L.P.	10% Owner	P Buy	2021-08-24	2021-08-24	40,170	$16.28	$654.0K	4,228,404	SEC↗
Aquilo Capital, L.P.	10% Owner	P Buy	2021-08-23	2021-08-24	137,835	$16.33	$2.25M	4,188,234	SEC↗
Aquilo Capital, L.P.	10% Owner	P Buy	2021-08-20	2021-08-24	221,190	$14.86	$3.29M	4,050,399	SEC↗
FORMELA JEAN FRANCOIS	Director	A Award deriv	2021-08-17	2021-08-18	7,500	—	$0	7,500	SEC↗
Jackson Scott Thomas	Director	A Award deriv	2021-08-17	2021-08-18	7,500	—	$0	7,500	SEC↗
VINK PATRICK V.J.J.	Director	A Award deriv	2021-08-17	2021-08-18	7,500	—	$0	7,500	SEC↗
THOMAS FRANK E	Director	A Award deriv	2021-08-17	2021-08-18	7,500	—	$0	7,500	SEC↗
Deshpande Milind	Director	A Award deriv	2021-08-17	2021-08-18	7,500	—	$0	7,500	SEC↗
Smith Cynthia	Director	A Award deriv	2021-08-17	2021-08-18	7,500	—	$0	7,500	SEC↗
Pottage John C Jr	Director	A Award deriv	2021-08-17	2021-08-18	7,500	—	$0	7,500	SEC↗
Aquilo Capital Management, LLC	10% Owner	S Sale	2021-02-08	2021-02-10	3,000	$21.74	$65.2K	3,829,209	SEC↗
Aquilo Capital, L.P.	10% Owner	S Sale	2021-02-04	2021-02-04	34,144	$18.99	$648.4K	3,832,209	SEC↗
Aquilo Capital, L.P.	10% Owner	S Sale	2021-02-03	2021-02-04	29,354	$18.98	$557.1K	3,866,353	SEC↗
Aquilo Capital, L.P.	10% Owner	S Sale	2021-02-02	2021-02-04	22,841	$18.99	$433.8K	3,895,707	SEC↗
Melnick David A.	Chief Medical Officer	A Award deriv	2021-02-01	2021-02-03	57,432	—	$0	57,432	SEC↗
Mahadevia Ankit	See Remarks	A Award deriv	2021-02-01	2021-02-03	179,319	—	$0	179,319	SEC↗
Larkin Cristina	Chief Operating Officer	A Award deriv	2021-02-01	2021-02-03	57,432	—	$0	57,432	SEC↗
Keutzer Timothy	Chief Development Officer	A Award deriv	2021-02-01	2021-02-03	57,432	—	$0	57,432	SEC↗
Aquilo Capital, L.P.	10% Owner	S Sale	2021-02-01	2021-02-04	13,661	$19.24	$262.8K	3,918,548	SEC↗
Shukla Sath	Chief Financial Officer	A Award deriv	2021-01-04	2021-01-05	75,000	—	$0	75,000	SEC↗
Deshpande Milind	Director	A Award deriv	2021-01-04	2021-01-06	2,629	$13.31	$35.0K	2,629	SEC↗
THOMAS FRANK E	Director	A Award deriv	2021-01-04	2021-01-06	1,314	$13.31	$17.5K	1,314	SEC↗
Smith Cynthia	Director	A Award deriv	2021-01-04	2021-01-06	2,629	$13.31	$35.0K	2,629	SEC↗
VINK PATRICK V.J.J.	Director	A Award deriv	2021-01-04	2021-01-06	1,314	$13.31	$17.5K	1,314	SEC↗
Aquilo Capital, L.P.	10% Owner	S Sale	2020-12-17	2020-12-18	250,000	$18.81	$4.70M	3,932,209	SEC↗
Larkin Cristina	Chief Operating Officer	M Exercise deriv	2020-12-16	2020-12-18	12,000	—	$0	8,434	SEC↗
Larkin Cristina	Chief Operating Officer	S Sale	2020-12-16	2020-12-18	12,000	$19.00	$228.0K	1,500	SEC↗
Larkin Cristina	Chief Operating Officer	M Exercise	2020-12-16	2020-12-18	12,000	$5.90	$70.8K	13,500	SEC↗
Aquilo Capital, L.P.	10% Owner	S Sale	2020-12-16	2020-12-18	14,933	$18.62	$278.1K	4,182,209	SEC↗
JOSEPH TAMARA L	Chief Legal Officer	A Award deriv	2020-12-02	2020-12-02	75,000	—	$0	75,000	SEC↗
Aquilo Capital, L.P.	10% Owner	S Sale	2020-11-09	2020-11-10	125,900	$13.77	$1.73M	4,197,142	SEC↗
Aquilo Capital, L.P.	10% Owner	S Sale	2020-11-06	2020-11-06	5,000	$13.77	$68.8K	4,323,042	SEC↗
Aquilo Capital, L.P.	10% Owner	S Sale	2020-11-05	2020-11-06	96,600	$13.98	$1.35M	4,328,042	SEC↗
Mahadevia Ankit	CEO and President	M Exercise deriv	2020-11-04	2020-11-05	7,370	—	$0	494,809	SEC↗
Mahadevia Ankit	CEO and President	M Exercise	2020-11-04	2020-11-05	7,370	$5.90	$43.5K	73,187	SEC↗
Mahadevia Ankit	CEO and President	S Sale	2020-11-04	2020-11-05	7,370	$14.43	$106.3K	65,817	SEC↗
Aquilo Capital, L.P.	10% Owner	S Sale	2020-11-04	2020-11-06	72,500	$14.26	$1.03M	4,424,642	SEC↗
Mahadevia Ankit	CEO and President	M Exercise deriv	2020-11-03	2020-11-05	2,137	—	$0	502,179	SEC↗
Mahadevia Ankit	CEO and President	M Exercise	2020-11-03	2020-11-05	2,137	$5.90	$12.6K	67,954	SEC↗
Mahadevia Ankit	CEO and President	S Sale	2020-11-03	2020-11-05	2,137	$14.27	$30.5K	65,817	SEC↗
Pottage John C Jr	Director	A Award deriv	2020-10-27	2020-10-27	7,500	—	$0	7,500	SEC↗
VINK PATRICK V.J.J.	Director	A Award deriv	2020-10-27	2020-10-27	7,500	—	$0	7,500	SEC↗
Deshpande Milind	Director	A Award deriv	2020-10-27	2020-10-27	7,500	—	$0	7,500	SEC↗
Jackson Scott Thomas	Director	A Award deriv	2020-10-27	2020-10-27	7,500	—	$0	7,500	SEC↗
Smith Cynthia	Director	A Award deriv	2020-10-27	2020-10-27	7,500	—	$0	7,500	SEC↗
THOMAS FRANK E	Director	A Award deriv	2020-10-27	2020-10-27	7,500	—	$0	7,500	SEC↗
FORMELA JEAN FRANCOIS	Director	A Award deriv	2020-10-27	2020-10-27	7,500	—	$0	7,500	SEC↗
Mahadevia Ankit	CEO and President	M Exercise deriv	2020-10-23	2020-10-27	20	—	$0	504,316	SEC↗
Mahadevia Ankit	CEO and President	M Exercise	2020-10-23	2020-10-27	20	$5.90	$118	65,837	SEC↗
Mahadevia Ankit	CEO and President	S Sale	2020-10-23	2020-10-27	20	$14.25	$285	65,817	SEC↗
Mahadevia Ankit	CEO and President	M Exercise deriv	2020-10-14	2020-10-15	105	—	$0	504,336	SEC↗
Mahadevia Ankit	CEO and President	M Exercise	2020-10-14	2020-10-15	105	$5.90	$620	65,922	SEC↗
Mahadevia Ankit	CEO and President	S Sale	2020-10-14	2020-10-15	105	$14.25	$1.5K	65,817	SEC↗
Mahadevia Ankit	CEO and President	M Exercise deriv	2020-10-13	2020-10-15	14,367	—	$0	504,441	SEC↗
Mahadevia Ankit	CEO and President	S Sale	2020-10-13	2020-10-15	14,367	$14.28	$205.2K	65,817	SEC↗
Mahadevia Ankit	CEO and President	M Exercise	2020-10-13	2020-10-15	14,367	$5.90	$84.8K	80,184	SEC↗
Mahadevia Ankit	CEO and President	M Exercise deriv	2020-09-08	2020-09-10	774	—	$0	518,808	SEC↗
Mahadevia Ankit	CEO and President	S Sale	2020-09-08	2020-09-10	774	$14.25	$11.0K	65,817	SEC↗
Mahadevia Ankit	CEO and President	M Exercise	2020-09-08	2020-09-10	774	$5.90	$4.6K	66,591	SEC↗
Mahadevia Ankit	CEO and President	M Exercise deriv	2020-07-09	2020-07-09	2,293	—	$0	519,582	SEC↗
Mahadevia Ankit	CEO and President	S Sale	2020-07-09	2020-07-09	2,293	$14.31	$32.8K	65,817	SEC↗
Mahadevia Ankit	CEO and President	M Exercise	2020-07-09	2020-07-09	2,293	$5.90	$13.5K	68,110	SEC↗
Mahadevia Ankit	CEO and President	M Exercise deriv	2020-07-07	2020-07-09	754	—	$0	521,875	SEC↗
Mahadevia Ankit	CEO and President	M Exercise	2020-07-07	2020-07-09	754	$5.90	$4.4K	66,571	SEC↗
Mahadevia Ankit	CEO and President	S Sale	2020-07-07	2020-07-09	754	$14.25	$10.7K	65,817	SEC↗
Mahadevia Ankit	CEO and President	M Exercise deriv	2020-06-25	2020-06-29	2,642	—	$0	522,629	SEC↗
Mahadevia Ankit	CEO and President	S Sale	2020-06-25	2020-06-29	2,642	$14.25	$37.6K	65,817	SEC↗
Mahadevia Ankit	CEO and President	M Exercise	2020-06-25	2020-06-29	2,642	$5.90	$15.6K	68,459	SEC↗
Mahadevia Ankit	CEO and President	M Exercise deriv	2020-06-24	2020-06-29	3,880	—	$0	525,271	SEC↗
Mahadevia Ankit	CEO and President	M Exercise	2020-06-24	2020-06-29	3,880	$5.90	$22.9K	69,697	SEC↗
Mahadevia Ankit	CEO and President	S Sale	2020-06-24	2020-06-29	3,880	$14.28	$55.4K	65,817	SEC↗
Jackson Scott Thomas	Director	A Award deriv	2020-06-23	2020-06-23	15,000	—	$0	15,000	SEC↗
Mahadevia Ankit	CEO and President	M Exercise deriv	2020-06-23	2020-06-29	8,045	—	$0	529,151	SEC↗
Mahadevia Ankit	CEO and President	S Sale	2020-06-23	2020-06-29	8,045	$14.33	$115.3K	65,817	SEC↗
Mahadevia Ankit	CEO and President	M Exercise	2020-06-23	2020-06-29	8,045	$5.90	$47.5K	73,862	SEC↗
Mahadevia Ankit	CEO and President	M Exercise deriv	2020-06-22	2020-06-29	2,613	—	$0	537,196	SEC↗
Mahadevia Ankit	CEO and President	S Sale	2020-06-22	2020-06-29	2,613	$14.30	$37.4K	65,817	SEC↗
Mahadevia Ankit	CEO and President	M Exercise	2020-06-22	2020-06-29	2,613	$5.90	$15.4K	68,430	SEC↗
Keutzer Timothy	Chief Development Officer	A Award deriv	2020-02-03	2020-02-03	55,000	—	$0	55,000	SEC↗
Larkin Cristina	Chief Operating Officer	A Award deriv	2020-02-03	2020-02-03	55,000	—	$0	55,000	SEC↗
Mahadevia Ankit	CEO and President	A Award deriv	2020-02-03	2020-02-03	180,000	—	$0	180,000	SEC↗
Melnick David A.	Chief Medical Officer	A Award deriv	2020-02-03	2020-02-03	55,000	—	$0	55,000	SEC↗
Deshpande Milind	Director	A Award deriv	2020-01-02	2020-01-06	5,408	$6.47	$35.0K	5,408	SEC↗
VINK PATRICK V.J.J.	Director	A Award deriv	2020-01-02	2020-01-06	5,408	$6.47	$35.0K	5,408	SEC↗
FORMELA JEAN FRANCOIS	Director	A Award deriv	2020-01-02	2020-01-06	5,408	$6.47	$35.0K	5,408	SEC↗
THOMAS FRANK E	Director	A Award deriv	2020-01-02	2020-01-06	2,704	$6.47	$17.5K	2,704	SEC↗
VINK PATRICK V.J.J.	Director	A Award deriv	2019-06-05	2019-06-05	6,073	—	$0	6,073	SEC↗
Deshpande Milind	Director	A Award deriv	2019-06-05	2019-06-05	6,073	—	$0	6,073	SEC↗
FORMELA JEAN FRANCOIS	Director	A Award deriv	2019-06-05	2019-06-05	6,073	—	$0	6,073	SEC↗
THOMAS FRANK E	Director	A Award deriv	2019-06-05	2019-06-05	6,073	—	$0	6,073	SEC↗
Pottage John C Jr	Director	A Award deriv	2019-06-05	2019-06-05	6,073	—	$0	6,073	SEC↗
Smith Cynthia	Director	A Award deriv	2019-06-05	2019-06-05	6,073	—	$0	6,073	SEC↗
Smith Cynthia	Director	A Award deriv	2019-03-29	2019-03-29	12,146	—	$0	12,146	SEC↗
Mahadevia Ankit	CEO and President	A Award deriv	2019-01-02	2019-01-02	180,000	—	$0	180,000	SEC↗
Sendek Joel	Chief Financial Officer	A Award deriv	2019-01-02	2019-01-02	65,000	—	$0	65,000	SEC↗
Larkin Cristina	Chief Operating Officer	A Award deriv	2019-01-02	2019-01-02	65,000	—	$0	65,000	SEC↗
Melnick David A.	Chief Medical Officer	A Award deriv	2019-01-02	2019-01-02	65,000	—	$0	65,000	SEC↗
Parr Thomas R JR	Chief Scientific Officer	A Award deriv	2019-01-02	2019-01-02	35,000	—	$0	35,000	SEC↗
Pottage John C Jr	Director	A Award deriv	2018-09-21	2018-09-21	12,146	—	$0	12,146	SEC↗
GLAXOSMITHKLINE PLC	10% Owner	P Buy	2018-07-17	2018-07-17	80,000	$12.50	$1.00M	1,934,006	SEC↗
Mahadevia Ankit	See Remarks	M Exercise deriv	2018-07-06	2018-07-06	1,600	—	$0	118,888	SEC↗
Mahadevia Ankit	See Remarks	S Sale	2018-07-06	2018-07-06	100	$17.62	$1.8K	66,317	SEC↗
Mahadevia Ankit	See Remarks	M Exercise	2018-07-06	2018-07-06	1,600	$5.90	$9.4K	67,417	SEC↗
Mahadevia Ankit	See Remarks	S Sale	2018-07-06	2018-07-06	100	$17.55	$1.8K	66,817	SEC↗
Mahadevia Ankit	See Remarks	S Sale	2018-07-06	2018-07-06	500	$17.50	$8.8K	66,917	SEC↗
Mahadevia Ankit	See Remarks	S Sale	2018-07-06	2018-07-06	400	$17.58	$7.0K	66,417	SEC↗
Mahadevia Ankit	See Remarks	S Sale	2018-07-06	2018-07-06	200	$17.92	$3.6K	65,817	SEC↗
Mahadevia Ankit	See Remarks	S Sale	2018-07-06	2018-07-06	200	$17.90	$3.6K	66,017	SEC↗
Mahadevia Ankit	See Remarks	S Sale	2018-07-06	2018-07-06	100	$17.71	$1.8K	66,217	SEC↗
Mahadevia Ankit	See Remarks	M Exercise deriv	2018-07-05	2018-07-06	3,076	—	$0	120,488	SEC↗
Sendek Joel	Chief Financial Officer	M Exercise deriv	2018-07-05	2018-07-06	2,000	—	$0	165,833	SEC↗
Larkin Cristina	Chief Operating Officer	M Exercise deriv	2018-07-05	2018-07-06	4,000	—	$0	20,434	SEC↗
Mahadevia Ankit	See Remarks	S Sale	2018-07-05	2018-07-06	3,076	$17.62	$54.2K	65,817	SEC↗
Mahadevia Ankit	See Remarks	M Exercise	2018-07-05	2018-07-06	3,076	$5.90	$18.1K	68,893	SEC↗
Sendek Joel	Chief Financial Officer	S Sale	2018-07-05	2018-07-06	2,000	$17.50	$35.0K	15,181	SEC↗
Sendek Joel	Chief Financial Officer	M Exercise	2018-07-05	2018-07-06	2,000	$5.90	$11.8K	17,181	SEC↗
Larkin Cristina	Chief Operating Officer	S Sale	2018-07-05	2018-07-06	4,000	$17.50	$70.0K	1,500	SEC↗
Larkin Cristina	Chief Operating Officer	M Exercise	2018-07-05	2018-07-06	4,000	$5.90	$23.6K	5,500	SEC↗
VINK PATRICK V.J.J.	Director	A Award deriv	2018-06-05	2018-06-06	6,073	—	$0	6,073	SEC↗
Deshpande Milind	Director	A Award deriv	2018-06-05	2018-06-06	6,073	—	$0	6,073	SEC↗
Breum Casper	Director	A Award deriv	2018-06-05	2018-06-06	6,073	—	$0	6,073	SEC↗
SOUTHWELL DAVID P	Director	A Award deriv	2018-06-05	2018-06-06	6,073	—	$0	6,073	SEC↗
FORMELA JEAN FRANCOIS	Director	A Award deriv	2018-06-05	2018-06-06	6,073	—	$0	6,073	SEC↗
THOMAS FRANK E	Director	A Award deriv	2018-06-05	2018-06-06	6,073	—	$0	6,073	SEC↗
SOUTHWELL DAVID P	Director	A Award deriv	2018-03-30	2018-03-30	12,146	—	$0	12,146	SEC↗
Melnick David A.	Chief Medical Officer	A Award deriv	2018-01-04	2018-01-05	135,000	—	$0	135,000	SEC↗
Mahadevia Ankit	See Remarks	A Award deriv	2017-12-13	2017-12-15	125,079	—	$0	125,079	SEC↗
Parr Thomas R JR	Chief Scientific Officer	A Award deriv	2017-12-13	2017-12-15	36,134	—	$0	36,134	SEC↗
Sendek Joel	Chief Financial Officer	A Award deriv	2017-12-13	2017-12-15	27,795	—	$0	27,795	SEC↗
Larkin Cristina	Chief Operating Officer	A Award deriv	2017-12-13	2017-12-15	62,540	—	$0	62,540	SEC↗