SYRE

Spyre Therapeutics, Inc.CIK 1636282 ☆ Sign in to watch Congress trades

Open-mkt buys · 90d

—

0 trades · 0 insiders

Open-mkt sales · 90d

$23.23M

51 trades · 4 insiders

Net · 90d

$-23.23M

Insiders on file

AI insights for SYRE PRO

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AI insights for SYRE

Insider sentiment score with a plain-English explanation, conviction score on every buy, and how the stock performed 30 and 90 days after past insider buys.

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Daily buy vs sell · 90 days

■ Open-market buys (P) ■ Open-market sales (S) · daily dollar value by transaction date

Insiders

Insider	Role	Trades	Bought	Sold	Last trade
Burrows Scott L	Chief Financial Officer	64	$0	$12.95M	2026-10-01
King-Jones Heidy	See Remarks	28	$0	$7.59M	2026-10-01
Turtle Cameron	Chief Executive Officer, Director	53	$0	$14.12M	2026-10-01
Albers Jeffrey W.	Director	18	$0	$5.07M	2026-08-07
Sloan Sheldon	Chief Medical Officer	22	$0	$7.35M	2026-07-01
Fairmount Funds Management LLC	Director	3	$0	$399.66M	2026-06-23
HENDERSON MICHAEL THOMAS	Director	10	$0	$7.95M	2026-06-22
Milligan Sandra	Director	3	$0	$0	2026-05-27
Fairmount Healthcare Fund II L.P.	Director, 10% Owner	6	$0	$0	2026-05-27
McKenna Mark C.	Director	3	$0	$0	2026-05-27
Stelzer Laurie	Director	3	$0	$0	2026-05-27
Harwin Peter Evan	Director, 10% Owner	5	$0	$0	2024-05-14

Trade history

Insider	Role	Code	Trade	Filed	Shares	Price	Value	Owned after
Turtle Cameron	Chief Executive Officer, Dir	S Sale	2026-10-01	2026-10-02	100	$93.91	$9.4K	537,540	SEC↗
Turtle Cameron	Chief Executive Officer, Dir	S Sale	2026-10-01	2026-10-02	4,990	$93.37	$465.9K	537,640	SEC↗
Turtle Cameron	Chief Executive Officer, Dir	S Sale	2026-10-01	2026-10-02	3,989	$92.31	$368.2K	542,630	SEC↗
Turtle Cameron	Chief Executive Officer, Dir	S Sale	2026-10-01	2026-10-02	2,638	$91.49	$241.4K	546,619	SEC↗
Turtle Cameron	Chief Executive Officer, Dir	S Sale	2026-10-01	2026-10-02	2,683	$90.10	$241.7K	549,257	SEC↗
Turtle Cameron	Chief Executive Officer, Dir	S Sale	2026-10-01	2026-10-02	600	$89.14	$53.5K	551,940	SEC↗
King-Jones Heidy	See Remarks	M Exercise deriv	2026-10-01	2026-10-02	28,933	—	$0	482,478	SEC↗
King-Jones Heidy	See Remarks	S Sale	2026-10-01	2026-10-02	2,600	$93.46	$243.0K	2,845	SEC↗
King-Jones Heidy	See Remarks	S Sale	2026-10-01	2026-10-02	2,100	$92.70	$194.7K	5,445	SEC↗
King-Jones Heidy	See Remarks	S Sale	2026-10-01	2026-10-02	7,228	$91.35	$660.3K	7,545	SEC↗
King-Jones Heidy	See Remarks	S Sale	2026-10-01	2026-10-02	16,605	$90.35	$1.50M	14,773	SEC↗
King-Jones Heidy	See Remarks	S Sale	2026-10-01	2026-10-02	400	$89.24	$35.7K	31,378	SEC↗
King-Jones Heidy	See Remarks	M Exercise	2026-10-01	2026-10-02	28,933	$14.50	$419.5K	31,778	SEC↗
Burrows Scott L	Chief Financial Officer	M Exercise deriv	2026-10-01	2026-10-02	7,500	—	$0	312,357	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-10-01	2026-10-02	229	$93.57	$21.4K	79,762	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-10-01	2026-10-02	3,071	$92.95	$285.4K	79,991	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-10-01	2026-10-02	2,100	$91.92	$193.0K	83,062	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-10-01	2026-10-02	1,500	$90.27	$135.4K	85,162	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-10-01	2026-10-02	600	$89.07	$53.4K	86,662	SEC↗
Burrows Scott L	Chief Financial Officer	M Exercise	2026-10-01	2026-10-02	7,500	$14.50	$108.8K	87,262	SEC↗
Burrows Scott L	Chief Financial Officer	M Exercise deriv	2026-09-30	2026-10-02	17,500	—	$0	319,857	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-09-30	2026-10-02	17,500	$89.89	$1.57M	79,762	SEC↗
Burrows Scott L	Chief Financial Officer	M Exercise	2026-09-30	2026-10-02	17,500	$14.50	$253.8K	97,262	SEC↗
King-Jones Heidy	See Remarks	M Exercise deriv	2026-09-02	2026-09-03	400	—	$0	511,411	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-09-02	2026-09-03	18,232	$89.35	$1.63M	79,762	SEC↗
King-Jones Heidy	See Remarks	M Exercise	2026-09-02	2026-09-03	400	$14.50	$5.8K	3,245	SEC↗
King-Jones Heidy	See Remarks	S Sale	2026-09-02	2026-09-03	400	$90.00	$36.0K	2,845	SEC↗
King-Jones Heidy	See Remarks	M Exercise deriv	2026-09-02	2026-09-03	400	—	$0	511,411	SEC↗
King-Jones Heidy	See Remarks	S Sale	2026-09-02	2026-09-03	400	$90.00	$36.0K	2,845	SEC↗
King-Jones Heidy	See Remarks	M Exercise	2026-09-02	2026-09-03	400	$14.50	$5.8K	3,245	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-09-02	2026-09-03	18,232	$89.35	$1.63M	79,762	SEC↗
Burrows Scott L	Chief Financial Officer	M Exercise deriv	2026-09-01	2026-09-03	7,500	—	$0	337,357	SEC↗
King-Jones Heidy	See Remarks	M Exercise deriv	2026-09-01	2026-09-03	27,999	—	$0	511,811	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-09-01	2026-09-03	3,700	$88.06	$325.8K	552,940	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-09-01	2026-09-03	400	$89.07	$35.6K	552,540	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-09-01	2026-09-03	2,500	$86.36	$215.9K	565,040	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-09-01	2026-09-03	8,400	$87.15	$732.1K	556,640	SEC↗
Burrows Scott L	Chief Financial Officer	M Exercise	2026-09-01	2026-09-03	7,500	$14.50	$108.8K	105,494	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-09-01	2026-09-03	4,384	$87.11	$381.9K	100,210	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-09-01	2026-09-03	900	$86.25	$77.6K	104,594	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-09-01	2026-09-03	2,016	$88.03	$177.5K	98,194	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-09-01	2026-09-03	200	$89.04	$17.8K	97,994	SEC↗
King-Jones Heidy	See Remarks	S Sale	2026-09-01	2026-09-03	400	$89.38	$35.8K	2,845	SEC↗
King-Jones Heidy	See Remarks	S Sale	2026-09-01	2026-09-03	6,206	$88.17	$547.2K	3,245	SEC↗
King-Jones Heidy	See Remarks	S Sale	2026-09-01	2026-09-03	16,548	$87.20	$1.44M	9,451	SEC↗
King-Jones Heidy	See Remarks	S Sale	2026-09-01	2026-09-03	4,845	$86.40	$418.6K	25,999	SEC↗
King-Jones Heidy	See Remarks	M Exercise	2026-09-01	2026-09-03	27,999	$14.50	$406.0K	30,844	SEC↗
Turtle Cameron	Chief Executive Officer, Dir	S Sale	2026-09-01	2026-09-03	400	$89.07	$35.6K	552,540	SEC↗
Turtle Cameron	Chief Executive Officer, Dir	S Sale	2026-09-01	2026-09-03	3,700	$88.06	$325.8K	552,940	SEC↗
Turtle Cameron	Chief Executive Officer, Dir	S Sale	2026-09-01	2026-09-03	8,400	$87.15	$732.1K	556,640	SEC↗
Turtle Cameron	Chief Executive Officer, Dir	S Sale	2026-09-01	2026-09-03	2,500	$86.36	$215.9K	565,040	SEC↗
King-Jones Heidy	See Remarks	M Exercise deriv	2026-09-01	2026-09-03	27,999	—	$0	511,811	SEC↗
King-Jones Heidy	See Remarks	S Sale	2026-09-01	2026-09-03	400	$89.38	$35.8K	2,845	SEC↗
King-Jones Heidy	See Remarks	S Sale	2026-09-01	2026-09-03	6,206	$88.17	$547.2K	3,245	SEC↗
King-Jones Heidy	See Remarks	S Sale	2026-09-01	2026-09-03	16,548	$87.20	$1.44M	9,451	SEC↗
King-Jones Heidy	See Remarks	S Sale	2026-09-01	2026-09-03	4,845	$86.40	$418.6K	25,999	SEC↗
King-Jones Heidy	See Remarks	M Exercise	2026-09-01	2026-09-03	27,999	$14.50	$406.0K	30,844	SEC↗
Burrows Scott L	Chief Financial Officer	M Exercise deriv	2026-09-01	2026-09-03	7,500	—	$0	337,357	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-09-01	2026-09-03	200	$89.04	$17.8K	97,994	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-09-01	2026-09-03	2,016	$88.03	$177.5K	98,194	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-09-01	2026-09-03	4,384	$87.11	$381.9K	100,210	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-09-01	2026-09-03	900	$86.25	$77.6K	104,594	SEC↗
Burrows Scott L	Chief Financial Officer	M Exercise	2026-09-01	2026-09-03	7,500	$14.50	$108.8K	105,494	SEC↗
Albers Jeffrey W.	Director	M Exercise deriv	2026-08-07	2026-08-10	5,000	—	$0	45,000	SEC↗
Albers Jeffrey W.	Director	S Sale	2026-08-07	2026-08-10	10,000	$104.68	$1.05M	9,360	SEC↗
Albers Jeffrey W.	Director	S Sale	2026-08-07	2026-08-10	8,000	$104.38	$835.0K	19,360	SEC↗
Albers Jeffrey W.	Director	S Sale	2026-08-07	2026-08-10	5,000	$104.47	$522.4K	0	SEC↗
Albers Jeffrey W.	Director	M Exercise	2026-08-07	2026-08-10	5,000	$10.39	$52.0K	5,000	SEC↗
Albers Jeffrey W.	Director	M Exercise deriv	2026-08-07	2026-08-10	5,000	—	$0	45,000	SEC↗
Albers Jeffrey W.	Director	S Sale	2026-08-07	2026-08-10	10,000	$104.68	$1.05M	9,360	SEC↗
Albers Jeffrey W.	Director	S Sale	2026-08-07	2026-08-10	8,000	$104.38	$835.0K	19,360	SEC↗
Albers Jeffrey W.	Director	S Sale	2026-08-07	2026-08-10	5,000	$104.47	$522.4K	0	SEC↗
Albers Jeffrey W.	Director	M Exercise	2026-08-07	2026-08-10	5,000	$10.39	$52.0K	5,000	SEC↗
Burrows Scott L	Chief Financial Officer	M Exercise deriv	2026-08-03	2026-08-05	7,500	—	$0	344,857	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-08-03	2026-08-05	16	$97.46	$1.6K	567,540	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-08-03	2026-08-05	1,392	$96.82	$134.8K	567,556	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-08-03	2026-08-05	5,635	$95.93	$540.6K	568,948	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-08-03	2026-08-05	7,157	$95.10	$680.6K	574,583	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-08-03	2026-08-05	800	$93.97	$75.2K	581,740	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-08-03	2026-08-05	100	$97.10	$9.7K	97,994	SEC↗
Burrows Scott L	Chief Financial Officer	M Exercise	2026-08-03	2026-08-05	7,500	$14.50	$108.8K	105,494	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-08-03	2026-08-05	5,100	$95.21	$485.6K	100,394	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-08-03	2026-08-05	2,300	$96.30	$221.5K	98,094	SEC↗
Turtle Cameron	Chief Executive Officer, Dir	S Sale	2026-08-03	2026-08-05	16	$97.46	$1.6K	567,540	SEC↗
Turtle Cameron	Chief Executive Officer, Dir	S Sale	2026-08-03	2026-08-05	1,392	$96.82	$134.8K	567,556	SEC↗
Turtle Cameron	Chief Executive Officer, Dir	S Sale	2026-08-03	2026-08-05	5,635	$95.93	$540.6K	568,948	SEC↗
Turtle Cameron	Chief Executive Officer, Dir	S Sale	2026-08-03	2026-08-05	7,157	$95.10	$680.6K	574,583	SEC↗
Turtle Cameron	Chief Executive Officer, Dir	S Sale	2026-08-03	2026-08-05	800	$93.97	$75.2K	581,740	SEC↗
Burrows Scott L	Chief Financial Officer	M Exercise deriv	2026-08-03	2026-08-05	7,500	—	$0	344,857	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-08-03	2026-08-05	100	$97.10	$9.7K	97,994	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-08-03	2026-08-05	2,300	$96.30	$221.5K	98,094	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-08-03	2026-08-05	5,100	$95.21	$485.6K	100,394	SEC↗
Burrows Scott L	Chief Financial Officer	M Exercise	2026-08-03	2026-08-05	7,500	$14.50	$108.8K	105,494	SEC↗
Sloan Sheldon	Chief Medical Officer	M Exercise deriv	2026-07-01	2026-07-02	8,334	—	$0	305,000	SEC↗
Burrows Scott L	Chief Financial Officer	M Exercise deriv	2026-07-01	2026-07-02	7,500	—	$0	352,357	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-07-01	2026-07-02	10,176	$87.44	$889.8K	587,364	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-07-01	2026-07-02	590	$88.91	$52.5K	582,540	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-07-01	2026-07-02	4,234	$88.12	$373.1K	583,130	SEC↗
Sloan Sheldon	Chief Medical Officer	M Exercise	2026-07-01	2026-07-02	8,334	$27.46	$228.9K	8,334	SEC↗
Sloan Sheldon	Chief Medical Officer	S Sale	2026-07-01	2026-07-02	6,500	$87.52	$568.9K	1,834	SEC↗
Sloan Sheldon	Chief Medical Officer	S Sale	2026-07-01	2026-07-02	1,834	$88.34	$162.0K	0	SEC↗
Burrows Scott L	Chief Financial Officer	M Exercise	2026-07-01	2026-07-02	7,500	$14.50	$108.8K	105,494	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-07-01	2026-07-02	1,725	$88.37	$152.4K	97,994	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-07-01	2026-07-02	5,775	$87.55	$505.6K	99,719	SEC↗
Burrows Scott L	Chief Financial Officer	M Exercise deriv	2026-06-25	2026-06-26	15,000	—	$0	359,857	SEC↗
Burrows Scott L	Chief Financial Officer	M Exercise	2026-06-25	2026-06-26	15,000	$14.50	$217.5K	112,994	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-06-25	2026-06-26	10,000	$87.14	$871.4K	97,994	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-06-25	2026-06-26	5,000	$87.12	$435.6K	107,994	SEC↗
Fairmount Funds Management LLC	Director	C Conversion deriv	2026-06-23	2026-06-23	16,667	—	$0	0	SEC↗
Fairmount Funds Management LLC	Director	S Sale	2026-06-23	2026-06-23	4,684,781	$85.31	$399.66M	0	SEC↗
Fairmount Funds Management LLC	Director	C Conversion	2026-06-23	2026-06-23	666,680	—	$0	4,684,781	SEC↗
HENDERSON MICHAEL THOMAS	Director	S Sale	2026-06-22	2026-06-23	20,000	$100.00	$2.00M	68,606	SEC↗
Sloan Sheldon	Chief Medical Officer	M Exercise deriv	2026-06-03	2026-06-03	8,333	—	$0	313,334	SEC↗
Sloan Sheldon	Chief Medical Officer	S Sale	2026-06-03	2026-06-03	8,333	$75.00	$625.0K	0	SEC↗
Sloan Sheldon	Chief Medical Officer	M Exercise	2026-06-03	2026-06-03	8,333	$27.46	$228.8K	8,333	SEC↗
Burrows Scott L	Chief Financial Officer	M Exercise deriv	2026-06-01	2026-06-03	7,500	—	$0	374,857	SEC↗
Burrows Scott L	Chief Financial Officer	M Exercise	2026-06-01	2026-06-03	7,500	$14.50	$108.8K	105,494	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-06-01	2026-06-03	1,801	$69.75	$125.6K	103,693	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-06-01	2026-06-03	2,599	$70.77	$183.9K	101,094	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-06-01	2026-06-03	3,100	$72.06	$223.4K	97,994	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-06-01	2026-06-03	3,557	$69.40	$246.9K	608,983	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-06-01	2026-06-03	8,149	$70.50	$574.5K	600,834	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-06-01	2026-06-03	3,294	$71.38	$235.1K	597,540	SEC↗
Milligan Sandra	Director	A Award deriv	2026-05-27	2026-05-29	8,026	—	$0	8,026	SEC↗
McKenna Mark C.	Director	A Award deriv	2026-05-27	2026-05-29	8,026	—	$0	8,026	SEC↗
Stelzer Laurie	Director	A Award deriv	2026-05-27	2026-05-29	8,026	—	$0	8,026	SEC↗
HENDERSON MICHAEL THOMAS	Director	A Award deriv	2026-05-27	2026-05-29	8,026	—	$0	8,026	SEC↗
Albers Jeffrey W.	Director	A Award deriv	2026-05-27	2026-05-29	8,026	—	$0	8,026	SEC↗
Fairmount Healthcare Fund II L	Director	A Award deriv	2026-05-27	2026-05-29	8,026	—	$0	8,026	SEC↗
HENDERSON MICHAEL THOMAS	Director	S Sale	2026-05-08	2026-05-08	33,513	$73.72	$2.47M	132,689	SEC↗
HENDERSON MICHAEL THOMAS	Director	S Sale	2026-05-08	2026-05-08	19,269	$75.35	$1.45M	88,606	SEC↗
HENDERSON MICHAEL THOMAS	Director	S Sale	2026-05-08	2026-05-08	24,814	$74.76	$1.86M	107,875	SEC↗
HENDERSON MICHAEL THOMAS	Director	S Sale	2026-05-08	2026-05-08	2,404	$72.57	$174.5K	166,202	SEC↗
Sloan Sheldon	Chief Medical Officer	M Exercise deriv	2026-05-01	2026-05-01	78,333	—	$0	321,667	SEC↗
Burrows Scott L	Chief Financial Officer	M Exercise deriv	2026-05-01	2026-05-01	12,500	—	$0	382,357	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-05-01	2026-05-01	1,700	$74.23	$126.2K	612,840	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-05-01	2026-05-01	300	$74.96	$22.5K	612,540	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-05-01	2026-05-01	5,300	$69.54	$368.6K	622,240	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-05-01	2026-05-01	3,600	$70.77	$254.8K	618,640	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-05-01	2026-05-01	1,000	$71.76	$71.8K	617,640	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-05-01	2026-05-01	3,100	$73.14	$226.7K	614,540	SEC↗
Sloan Sheldon	Chief Medical Officer	S Sale	2026-05-01	2026-05-01	21,306	$69.53	$1.48M	57,027	SEC↗
Sloan Sheldon	Chief Medical Officer	S Sale	2026-05-01	2026-05-01	400	$75.37	$30.1K	0	SEC↗
Sloan Sheldon	Chief Medical Officer	S Sale	2026-05-01	2026-05-01	19,656	$70.61	$1.39M	37,371	SEC↗
Sloan Sheldon	Chief Medical Officer	S Sale	2026-05-01	2026-05-01	8,777	$71.56	$628.1K	28,594	SEC↗
Sloan Sheldon	Chief Medical Officer	S Sale	2026-05-01	2026-05-01	12,777	$72.94	$932.0K	15,817	SEC↗
Sloan Sheldon	Chief Medical Officer	S Sale	2026-05-01	2026-05-01	10,358	$73.74	$763.8K	5,459	SEC↗
Sloan Sheldon	Chief Medical Officer	S Sale	2026-05-01	2026-05-01	5,059	$74.60	$377.4K	400	SEC↗
Sloan Sheldon	Chief Medical Officer	M Exercise	2026-05-01	2026-05-01	78,333	$27.46	$2.15M	78,333	SEC↗
Burrows Scott L	Chief Financial Officer	M Exercise	2026-05-01	2026-05-01	12,500	$14.50	$181.3K	110,494	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-05-01	2026-05-01	12,500	$71.37	$892.1K	97,994	SEC↗
Burrows Scott L	Chief Financial Officer	M Exercise deriv	2026-04-01	2026-04-03	7,500	—	$0	394,857	SEC↗
Sloan Sheldon	Chief Medical Officer	M Exercise deriv	2026-04-01	2026-04-03	7,958	—	$0	87,542	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-04-01	2026-04-03	1,300	$49.98	$65.0K	97,994	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-04-01	2026-04-03	6,200	$49.21	$305.1K	99,294	SEC↗
Burrows Scott L	Chief Financial Officer	M Exercise	2026-04-01	2026-04-03	7,500	$14.50	$108.8K	105,494	SEC↗
Sloan Sheldon	Chief Medical Officer	M Exercise	2026-04-01	2026-04-03	7,958	$21.66	$172.4K	7,958	SEC↗
Sloan Sheldon	Chief Medical Officer	S Sale	2026-04-01	2026-04-03	7,958	$50.00	$397.9K	0	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-04-01	2026-04-03	12,344	$49.20	$607.3K	630,196	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-04-01	2026-04-03	2,656	$49.92	$132.6K	627,540	SEC↗
Burrows Scott L	Chief Financial Officer	M Exercise deriv	2026-03-03	2026-03-03	2,500	—	$0	402,357	SEC↗
Burrows Scott L	Chief Financial Officer	M Exercise	2026-03-03	2026-03-03	2,500	$14.50	$36.3K	100,494	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-03-03	2026-03-03	2,300	$40.56	$93.3K	98,194	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2026-03-03	2026-03-03	200	$41.66	$8.3K	97,994	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-03-02	2026-03-03	5,900	$41.73	$246.2K	651,640	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-03-02	2026-03-03	9,100	$42.49	$386.7K	642,540	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-02-02	2026-02-04	14,043	$32.87	$461.6K	657,540	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-02-02	2026-02-04	957	$31.82	$30.5K	671,583	SEC↗
HENDERSON MICHAEL THOMAS	Director	J Other	2026-01-21	2026-01-23	63,227	—	$0	168,606	SEC↗
King-Jones Heidy	See Remarks	A Award deriv	2026-01-09	2026-01-13	140,000	—	$0	140,000	SEC↗
Sloan Sheldon	Chief Medical Officer	A Award deriv	2026-01-09	2026-01-13	140,000	—	$0	140,000	SEC↗
Turtle Cameron	Chief Executive Officer	A Award deriv	2026-01-09	2026-01-13	528,000	—	$0	528,000	SEC↗
Burrows Scott L	Chief Financial Officer	A Award deriv	2026-01-09	2026-01-13	140,000	—	$0	140,000	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-01-02	2026-01-06	2,191	$31.79	$69.7K	672,007	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-01-02	2026-01-06	100	$32.39	$3.2K	671,907	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2026-01-02	2026-01-06	12,709	$30.47	$387.2K	674,198	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2025-12-01	2025-12-03	10,995	$28.73	$315.9K	690,912	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2025-12-01	2025-12-03	4,005	$29.83	$119.5K	686,907	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2025-11-03	2025-11-05	16,845	$23.66	$398.6K	701,907	SEC↗
Turtle Cameron	Chief Executive Officer	S Sale	2025-11-03	2025-11-05	28,155	$23.13	$651.2K	718,752	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2025-09-02	2025-09-03	18,428	$16.26	$299.6K	97,994	SEC↗
Albers Jeffrey W.	Director	A Award deriv	2025-05-29	2025-06-02	25,000	—	$0	25,000	SEC↗
HENDERSON MICHAEL THOMAS	Director	A Award deriv	2025-05-29	2025-06-02	25,000	—	$0	25,000	SEC↗
McKenna Mark C.	Director	A Award deriv	2025-05-29	2025-06-02	25,000	—	$0	25,000	SEC↗
Milligan Sandra	Director	A Award deriv	2025-05-29	2025-06-02	25,000	—	$0	25,000	SEC↗
Stelzer Laurie	Director	A Award deriv	2025-05-29	2025-06-02	25,000	—	$0	25,000	SEC↗
Fairmount Healthcare Fund II L	Director	A Award deriv	2025-05-29	2025-06-02	25,000	—	$0	25,000	SEC↗
Fairmount Healthcare Fund II L	Director	A Award deriv	2025-05-29	2025-06-02	25,000	—	$0	25,000	SEC↗
King-Jones Heidy	See Remarks	A Award deriv	2025-01-15	2025-01-17	95,500	—	$0	95,500	SEC↗
Turtle Cameron	Chief Executive Officer	A Award deriv	2025-01-15	2025-01-17	370,000	—	$0	370,000	SEC↗
Sloan Sheldon	Chief Medical Officer	A Award deriv	2025-01-15	2025-01-17	95,500	—	$0	95,500	SEC↗
Burrows Scott L	Chief Financial Officer	A Award deriv	2025-01-15	2025-01-17	95,500	—	$0	95,500	SEC↗
HENDERSON MICHAEL THOMAS	Director	J Other	2025-01-10	2025-01-14	105,379	—	$0	105,379	SEC↗
Albers Jeffrey W.	Director	S Sale	2024-11-06	2024-11-08	6,700	$36.76	$246.3K	27,360	SEC↗
Albers Jeffrey W.	Director	S Sale	2024-10-25	2024-10-28	300	$36.43	$10.9K	34,060	SEC↗
Sloan Sheldon	Chief Medical Officer	A Award deriv	2024-10-01	2024-10-01	400,000	—	$0	400,000	SEC↗
Burrows Scott L	Chief Financial Officer	S Sale	2024-09-03	2024-09-05	18,531	$28.17	$522.0K	116,422	SEC↗
Harwin Peter Evan	Director	A Award deriv	2024-05-14	2024-05-16	11,323	—	$0	11,323	SEC↗
Harwin Peter Evan	Director	A Award deriv	2024-05-14	2024-05-16	11,323	—	$0	11,323	SEC↗
HENDERSON MICHAEL THOMAS	Director	A Award deriv	2024-05-14	2024-05-16	11,323	—	$0	11,323	SEC↗
Milligan Sandra	Director	A Award deriv	2024-05-14	2024-05-16	21,980	—	$0	21,980	SEC↗
Albers Jeffrey W.	Director	A Award deriv	2024-05-14	2024-05-16	11,323	—	$0	11,323	SEC↗
Stelzer Laurie	Director	A Award deriv	2024-05-14	2024-05-16	11,323	—	$0	11,323	SEC↗
Harwin Peter Evan	Director	M Exercise deriv	2024-04-25	2024-04-25	90,992	—	$0	346,045	SEC↗
Harwin Peter Evan	Director	M Exercise	2024-04-25	2024-04-25	3,639,680	—	$0	4,018,101	SEC↗
Turtle Cameron	Chief Executive Officer	A Award	2024-02-15	2024-02-20	400	$9.82	$3.9K	746,907	SEC↗
King-Jones Heidy	See Remarks	A Award deriv	2024-02-01	2024-02-02	63,000	—	$0	63,000	SEC↗
Burrows Scott L	Chief Financial Officer	A Award deriv	2024-02-01	2024-02-02	70,000	—	$0	70,000	SEC↗
Turtle Cameron	Chief Executive Officer	A Award deriv	2024-02-01	2024-02-02	277,750	—	$0	277,750	SEC↗
McKenna Mark C.	Director	A Award deriv	2024-02-01	2024-02-05	40,000	—	$0	40,000	SEC↗
Fairmount Healthcare Fund II L	Director, 10% Owner	J Other	2023-12-29	2023-12-29	3,435,480	—	$0	0	SEC↗
Fairmount Healthcare Fund II L	Director, 10% Owner	J Other	2023-12-29	2023-12-29	406,038	—	$0	406,038	SEC↗
Fairmount Healthcare Fund II L	Director, 10% Owner	J Other	2023-12-29	2023-12-29	406,038	—	$0	406,038	SEC↗
Burrows Scott L	Chief Financial Officer	A Award	2023-12-22	2023-12-22	134,953	—	$0	134,953	SEC↗
Harwin Peter Evan	Director, 10% Owner	A Award deriv	2023-12-07	2023-12-11	16,667	$600.00	$10.00M	16,667	SEC↗
Albers Jeffrey W.	Director	C Conversion deriv	2023-11-24	2023-12-08	859	—	$0	0	SEC↗
Albers Jeffrey W.	Director	C Conversion	2023-11-24	2023-12-08	34,360	—	$0	34,360	SEC↗
Albers Jeffrey W.	Director	A Award deriv	2023-11-22	2023-12-08	50,000	—	$0	50,000	SEC↗