Open-mkt buys · 90d
—
0 trades · 0 insiders
Open-mkt sales · 90d
$147.14M
95 trades · 9 insiders
Net · 90d
$-147.14M
Insiders on file
19
Daily buy vs sell · 90 days
■ Open-market buys (P) ■ Open-market sales (S) · daily dollar value by transaction date
Insiders
| Insider | Role | Trades | Bought | Sold | Last trade |
|---|---|---|---|---|---|
| Dube Eric M | Chief Executive Officer | 114 | $0 | $84.82M | 2026-10-15 |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICER | 96 | $0 | $37.67M | 2026-09-17 |
| ROTE WILLIAM E. | Senior Vice President, R&D | 95 | $0 | $30.92M | 2026-09-16 |
| Cline Christopher R. | Chief Financial Officer | 62 | $0 | $8.16M | 2026-09-15 |
| Inrig Jula | EVP, Head of R&D & CMO | 60 | $0 | $8.29M | 2026-09-15 |
| Calvin Sandra | VP, Corp Controller and CAO | 84 | $0 | $6.63M | 2026-09-15 |
| REED ELIZABETH E | SVP, GC & Corporate Secretary | 103 | $0 | $11.10M | 2026-09-15 |
| Meckler Jeffrey A | Director | 34 | $0 | $3.61M | 2026-09-10 |
| LYONS GARY A | Director | 37 | $0 | $2.18M | 2026-08-18 |
| Baynes Roy D. | Director | 42 | $0 | $3.09M | 2026-06-12 |
| Coughlin Timothy | Director | 21 | $0 | $1.27M | 2026-06-12 |
| Poole Sandra | Director | 12 | $0 | $0 | 2026-05-19 |
| Bruhn Suzanne Louise | Director | 12 | $0 | $0 | 2026-05-19 |
| Orwin John A | Director | 12 | $0 | $0 | 2026-05-19 |
| Squarer Ron | Director | 12 | $0 | $0 | 2026-05-19 |
| Williams Brinkley Ruth | Director | 12 | $0 | $0 | 2026-05-19 |
| Clague Laura | Chief Financial Officer | 24 | $0 | $797.6K | 2022-05-11 |
| ASELAGE STEVE | Director | 31 | $0 | $4.97M | 2022-05-11 |
| Rosenberg Noah L. | Chief Medical Officer | 15 | $0 | $234.9K | 2021-08-17 |
Trade history
| Insider | Role | Code | Trade | Filed | Shares | Price | Value | Owned after | |
|---|---|---|---|---|---|---|---|---|---|
| Dube Eric M | CHIEF EXECUTIVE OFFICER, Dir | M Exercise deriv | 2026-10-15 | 2026-10-19 | 200,000 | — | $0 | 160,000 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER, Dir | M Exercise deriv | 2026-10-15 | 2026-10-19 | 43,735 | — | $0 | 168,925 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER, Dir | S Sale | 2026-10-15 | 2026-10-19 | 78,400 | $55.02 | $4.31M | 432,886 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER, Dir | S Sale | 2026-10-15 | 2026-10-19 | 37,270 | $54.20 | $2.02M | 511,286 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER, Dir | S Sale | 2026-10-15 | 2026-10-19 | 128,065 | $52.97 | $6.78M | 548,556 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER, Dir | M Exercise | 2026-10-15 | 2026-10-19 | 200,000 | $8.93 | $1.79M | 676,621 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER, Dir | M Exercise | 2026-10-15 | 2026-10-19 | 43,735 | $26.88 | $1.18M | 476,621 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER | M Exercise deriv | 2026-09-17 | 2026-09-17 | 108,493 | — | $0 | 0 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise deriv | 2026-09-17 | 2026-09-17 | 8,282 | — | $0 | 44,837 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER | S Sale | 2026-09-17 | 2026-09-17 | 101,691 | $64.59 | $6.57M | 439,688 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER | M Exercise | 2026-09-17 | 2026-09-17 | 108,493 | $23.34 | $2.53M | 541,379 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER | S Sale | 2026-09-17 | 2026-09-17 | 6,802 | $64.95 | $441.8K | 432,886 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | S Sale | 2026-09-17 | 2026-09-17 | 8,282 | $65.07 | $538.9K | 117,066 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise | 2026-09-17 | 2026-09-17 | 8,282 | $22.40 | $185.5K | 125,348 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise deriv | 2026-09-17 | 2026-09-17 | 8,282 | — | $0 | 44,837 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | S Sale | 2026-09-17 | 2026-09-17 | 8,282 | $65.07 | $538.9K | 117,066 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise | 2026-09-17 | 2026-09-17 | 8,282 | $22.40 | $185.5K | 125,348 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER, Dir | M Exercise deriv | 2026-09-17 | 2026-09-17 | 108,493 | — | $0 | 0 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER, Dir | S Sale | 2026-09-17 | 2026-09-17 | 6,802 | $64.95 | $441.8K | 432,886 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER, Dir | S Sale | 2026-09-17 | 2026-09-17 | 101,691 | $64.59 | $6.57M | 439,688 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER, Dir | M Exercise | 2026-09-17 | 2026-09-17 | 108,493 | $23.34 | $2.53M | 541,379 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER | M Exercise deriv | 2026-09-16 | 2026-09-17 | 195,841 | — | $0 | 108,493 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise deriv | 2026-09-16 | 2026-09-17 | 100,000 | — | $0 | 0 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise deriv | 2026-09-16 | 2026-09-17 | 55,000 | — | $0 | 0 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise deriv | 2026-09-16 | 2026-09-17 | 17,717 | — | $0 | 500 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | M Exercise deriv | 2026-09-16 | 2026-09-17 | 350 | — | $0 | 0 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | M Exercise deriv | 2026-09-16 | 2026-09-17 | 55,000 | — | $0 | 0 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | M Exercise deriv | 2026-09-16 | 2026-09-17 | 57,500 | — | $0 | 0 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER | M Exercise | 2026-09-16 | 2026-09-17 | 195,841 | $23.34 | $4.57M | 628,727 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER | S Sale | 2026-09-16 | 2026-09-17 | 96,125 | $63.64 | $6.12M | 432,886 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER | S Sale | 2026-09-16 | 2026-09-17 | 99,716 | $63.26 | $6.31M | 529,011 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise | 2026-09-16 | 2026-09-17 | 100,000 | $11.25 | $1.13M | 217,066 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | S Sale | 2026-09-16 | 2026-09-17 | 79,113 | $63.65 | $5.04M | 117,066 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | S Sale | 2026-09-16 | 2026-09-17 | 93,604 | $63.25 | $5.92M | 196,179 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise | 2026-09-16 | 2026-09-17 | 17,717 | $26.88 | $476.2K | 289,783 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise | 2026-09-16 | 2026-09-17 | 55,000 | $15.46 | $850.3K | 272,066 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | S Sale | 2026-09-16 | 2026-09-17 | 47,746 | $63.61 | $3.04M | 98,197 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | S Sale | 2026-09-16 | 2026-09-17 | 65,104 | $63.12 | $4.11M | 145,943 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | M Exercise | 2026-09-16 | 2026-09-17 | 57,500 | $26.88 | $1.55M | 211,047 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | M Exercise | 2026-09-16 | 2026-09-17 | 55,000 | $15.46 | $850.3K | 153,547 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | M Exercise | 2026-09-16 | 2026-09-17 | 350 | $17.96 | $6.3K | 98,547 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | M Exercise deriv | 2026-09-16 | 2026-09-17 | 57,500 | — | $0 | 0 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | M Exercise deriv | 2026-09-16 | 2026-09-17 | 55,000 | — | $0 | 0 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | M Exercise deriv | 2026-09-16 | 2026-09-17 | 350 | — | $0 | 0 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | S Sale | 2026-09-16 | 2026-09-17 | 47,746 | $63.61 | $3.04M | 98,197 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | S Sale | 2026-09-16 | 2026-09-17 | 65,104 | $63.12 | $4.11M | 145,943 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | M Exercise | 2026-09-16 | 2026-09-17 | 57,500 | $26.88 | $1.55M | 211,047 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | M Exercise | 2026-09-16 | 2026-09-17 | 55,000 | $15.46 | $850.3K | 153,547 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | M Exercise | 2026-09-16 | 2026-09-17 | 350 | $17.96 | $6.3K | 98,547 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise deriv | 2026-09-16 | 2026-09-17 | 17,717 | — | $0 | 500 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise deriv | 2026-09-16 | 2026-09-17 | 55,000 | — | $0 | 0 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise deriv | 2026-09-16 | 2026-09-17 | 100,000 | — | $0 | 0 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | S Sale | 2026-09-16 | 2026-09-17 | 79,113 | $63.65 | $5.04M | 117,066 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | S Sale | 2026-09-16 | 2026-09-17 | 93,604 | $63.25 | $5.92M | 196,179 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise | 2026-09-16 | 2026-09-17 | 17,717 | $26.88 | $476.2K | 289,783 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise | 2026-09-16 | 2026-09-17 | 55,000 | $15.46 | $850.3K | 272,066 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise | 2026-09-16 | 2026-09-17 | 100,000 | $11.25 | $1.13M | 217,066 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER, Dir | M Exercise deriv | 2026-09-16 | 2026-09-17 | 195,841 | — | $0 | 108,493 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER, Dir | S Sale | 2026-09-16 | 2026-09-17 | 96,125 | $63.64 | $6.12M | 432,886 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER, Dir | S Sale | 2026-09-16 | 2026-09-17 | 99,716 | $63.26 | $6.31M | 529,011 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER, Dir | M Exercise | 2026-09-16 | 2026-09-17 | 195,841 | $23.34 | $4.57M | 628,727 | SEC↗ |
| Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICE | M Exercise deriv | 2026-09-15 | 2026-09-17 | 1,250 | — | $0 | 3,750 | SEC↗ |
| Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICE | M Exercise deriv | 2026-09-15 | 2026-09-17 | 2,500 | — | $0 | 0 | SEC↗ |
| Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICE | M Exercise deriv | 2026-09-15 | 2026-09-17 | 1,625 | — | $0 | 17,875 | SEC↗ |
| Cline Christopher R. | CHIEF FINANCIAL OFFICER | M Exercise deriv | 2026-09-15 | 2026-09-17 | 20,000 | — | $0 | 0 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER | M Exercise deriv | 2026-09-15 | 2026-09-17 | 95,666 | — | $0 | 304,334 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | M Exercise deriv | 2026-09-15 | 2026-09-17 | 37,500 | — | $0 | 0 | SEC↗ |
| Inrig Jula | EVP, Head of R&D & CMO | M Exercise deriv | 2026-09-15 | 2026-09-17 | 32,395 | — | $0 | 43,605 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise deriv | 2026-09-15 | 2026-09-17 | 36,526 | — | $0 | 28,474 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise deriv | 2026-09-15 | 2026-09-17 | 1,381 | — | $0 | 53,119 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise deriv | 2026-09-15 | 2026-09-17 | 39,283 | — | $0 | 18,217 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | M Exercise deriv | 2026-09-15 | 2026-09-17 | 39,650 | — | $0 | 350 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | M Exercise deriv | 2026-09-15 | 2026-09-17 | 39,000 | — | $0 | 0 | SEC↗ |
| Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICE | M Exercise | 2026-09-15 | 2026-09-17 | 1,625 | $20.46 | $33.2K | 47,728 | SEC↗ |
| Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICE | S Sale | 2026-09-15 | 2026-09-17 | 800 | $62.85 | $50.3K | 42,653 | SEC↗ |
| Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICE | S Sale | 2026-09-15 | 2026-09-17 | 4,275 | $62.14 | $265.6K | 43,453 | SEC↗ |
| Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICE | S Sale | 2026-09-15 | 2026-09-17 | 300 | $63.66 | $19.1K | 42,353 | SEC↗ |
| Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICE | M Exercise | 2026-09-15 | 2026-09-17 | 1,250 | $22.40 | $28.0K | 46,103 | SEC↗ |
| Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICE | M Exercise | 2026-09-15 | 2026-09-17 | 2,500 | $27.50 | $68.8K | 44,853 | SEC↗ |
| Cline Christopher R. | CHIEF FINANCIAL OFFICER | S Sale | 2026-09-15 | 2026-09-17 | 1,900 | $63.69 | $121.0K | 87,908 | SEC↗ |
| Cline Christopher R. | CHIEF FINANCIAL OFFICER | S Sale | 2026-09-15 | 2026-09-17 | 20,735 | $62.61 | $1.30M | 89,808 | SEC↗ |
| Cline Christopher R. | CHIEF FINANCIAL OFFICER | S Sale | 2026-09-15 | 2026-09-17 | 400 | $65.31 | $26.1K | 87,508 | SEC↗ |
| Cline Christopher R. | CHIEF FINANCIAL OFFICER | M Exercise | 2026-09-15 | 2026-09-17 | 20,000 | $17.44 | $348.8K | 138,016 | SEC↗ |
| Cline Christopher R. | CHIEF FINANCIAL OFFICER | S Sale | 2026-09-15 | 2026-09-17 | 27,473 | $62.00 | $1.70M | 110,543 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER | S Sale | 2026-09-15 | 2026-09-17 | 270 | $65.31 | $17.6K | 432,886 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER | S Sale | 2026-09-15 | 2026-09-17 | 3,102 | $63.64 | $197.4K | 433,156 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER | S Sale | 2026-09-15 | 2026-09-17 | 28,796 | $62.66 | $1.80M | 436,258 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER | S Sale | 2026-09-15 | 2026-09-17 | 63,498 | $61.99 | $3.94M | 465,054 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER | M Exercise | 2026-09-15 | 2026-09-17 | 95,666 | $23.34 | $2.23M | 528,552 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | M Exercise | 2026-09-15 | 2026-09-17 | 37,500 | $15.46 | $579.8K | 142,889 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | S Sale | 2026-09-15 | 2026-09-17 | 21,926 | $62.03 | $1.36M | 120,963 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | S Sale | 2026-09-15 | 2026-09-17 | 13,874 | $62.63 | $868.9K | 107,089 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | S Sale | 2026-09-15 | 2026-09-17 | 300 | $65.31 | $19.6K | 105,389 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | S Sale | 2026-09-15 | 2026-09-17 | 1,400 | $63.69 | $89.2K | 105,689 | SEC↗ |
| Inrig Jula | EVP, Head of R&D & CMO | S Sale | 2026-09-15 | 2026-09-17 | 17,284 | $62.62 | $1.08M | 102,491 | SEC↗ |
| Inrig Jula | EVP, Head of R&D & CMO | S Sale | 2026-09-15 | 2026-09-17 | 1,600 | $63.69 | $101.9K | 100,891 | SEC↗ |
| Inrig Jula | EVP, Head of R&D & CMO | S Sale | 2026-09-15 | 2026-09-17 | 400 | $65.31 | $26.1K | 100,491 | SEC↗ |
| Inrig Jula | EVP, Head of R&D & CMO | S Sale | 2026-09-15 | 2026-09-17 | 25,390 | $62.02 | $1.57M | 119,775 | SEC↗ |
| Inrig Jula | EVP, Head of R&D & CMO | M Exercise | 2026-09-15 | 2026-09-17 | 32,395 | $8.93 | $289.3K | 145,165 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise | 2026-09-15 | 2026-09-17 | 39,283 | $26.88 | $1.06M | 181,349 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise | 2026-09-15 | 2026-09-17 | 1,381 | $22.40 | $30.9K | 182,730 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise | 2026-09-15 | 2026-09-17 | 36,526 | $8.93 | $326.2K | 219,256 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | S Sale | 2026-09-15 | 2026-09-17 | 71,938 | $62.05 | $4.46M | 147,318 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | S Sale | 2026-09-15 | 2026-09-17 | 27,421 | $62.59 | $1.72M | 119,897 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | S Sale | 2026-09-15 | 2026-09-17 | 1,400 | $63.65 | $89.1K | 118,497 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | S Sale | 2026-09-15 | 2026-09-17 | 1,431 | $65.31 | $93.5K | 117,066 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | M Exercise | 2026-09-15 | 2026-09-17 | 39,650 | $17.96 | $712.1K | 194,395 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | M Exercise | 2026-09-15 | 2026-09-17 | 39,000 | $25.25 | $984.8K | 154,745 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | S Sale | 2026-09-15 | 2026-09-17 | 270 | $65.31 | $17.6K | 98,197 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | S Sale | 2026-09-15 | 2026-09-17 | 3,000 | $63.65 | $190.9K | 98,467 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | S Sale | 2026-09-15 | 2026-09-17 | 29,021 | $62.66 | $1.82M | 101,467 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | S Sale | 2026-09-15 | 2026-09-17 | 63,907 | $61.99 | $3.96M | 130,488 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | M Exercise deriv | 2026-09-15 | 2026-09-17 | 39,650 | — | $0 | 350 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | M Exercise deriv | 2026-09-15 | 2026-09-17 | 39,000 | — | $0 | 0 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | S Sale | 2026-09-15 | 2026-09-17 | 270 | $65.31 | $17.6K | 98,197 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | S Sale | 2026-09-15 | 2026-09-17 | 3,000 | $63.65 | $191.0K | 98,467 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | S Sale | 2026-09-15 | 2026-09-17 | 29,021 | $62.66 | $1.82M | 101,467 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | S Sale | 2026-09-15 | 2026-09-17 | 63,907 | $61.99 | $3.96M | 130,488 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | M Exercise | 2026-09-15 | 2026-09-17 | 39,650 | $17.96 | $712.1K | 194,395 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | M Exercise | 2026-09-15 | 2026-09-17 | 39,000 | $25.25 | $984.8K | 154,745 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | M Exercise deriv | 2026-09-15 | 2026-09-17 | 37,500 | — | $0 | 0 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | S Sale | 2026-09-15 | 2026-09-17 | 300 | $65.31 | $19.6K | 105,389 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | S Sale | 2026-09-15 | 2026-09-17 | 1,400 | $63.69 | $89.2K | 105,689 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | S Sale | 2026-09-15 | 2026-09-17 | 13,874 | $62.63 | $869.0K | 107,089 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | S Sale | 2026-09-15 | 2026-09-17 | 21,926 | $62.03 | $1.36M | 120,963 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | M Exercise | 2026-09-15 | 2026-09-17 | 37,500 | $15.46 | $579.8K | 142,889 | SEC↗ |
| Inrig Jula | EVP, Head of R&D & CMO | M Exercise deriv | 2026-09-15 | 2026-09-17 | 32,395 | — | $0 | 43,605 | SEC↗ |
| Inrig Jula | EVP, Head of R&D & CMO | S Sale | 2026-09-15 | 2026-09-17 | 400 | $65.31 | $26.1K | 100,491 | SEC↗ |
| Inrig Jula | EVP, Head of R&D & CMO | S Sale | 2026-09-15 | 2026-09-17 | 1,600 | $63.69 | $101.9K | 100,891 | SEC↗ |
| Inrig Jula | EVP, Head of R&D & CMO | S Sale | 2026-09-15 | 2026-09-17 | 17,284 | $62.62 | $1.08M | 102,491 | SEC↗ |
| Inrig Jula | EVP, Head of R&D & CMO | S Sale | 2026-09-15 | 2026-09-17 | 25,390 | $62.02 | $1.57M | 119,775 | SEC↗ |
| Inrig Jula | EVP, Head of R&D & CMO | M Exercise | 2026-09-15 | 2026-09-17 | 32,395 | $8.93 | $289.3K | 145,165 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise deriv | 2026-09-15 | 2026-09-17 | 36,526 | — | $0 | 28,474 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise deriv | 2026-09-15 | 2026-09-17 | 1,381 | — | $0 | 53,119 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise deriv | 2026-09-15 | 2026-09-17 | 39,283 | — | $0 | 18,217 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | S Sale | 2026-09-15 | 2026-09-17 | 1,431 | $65.31 | $93.5K | 117,066 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | S Sale | 2026-09-15 | 2026-09-17 | 1,400 | $63.65 | $89.1K | 118,497 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | S Sale | 2026-09-15 | 2026-09-17 | 27,421 | $62.59 | $1.72M | 119,897 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | S Sale | 2026-09-15 | 2026-09-17 | 71,938 | $62.05 | $4.46M | 147,318 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise | 2026-09-15 | 2026-09-17 | 36,526 | $8.93 | $326.2K | 219,256 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise | 2026-09-15 | 2026-09-17 | 1,381 | $22.40 | $30.9K | 182,730 | SEC↗ |
| Heerma Peter | EVP, CHIEF COMMERCIAL OFFICE | M Exercise | 2026-09-15 | 2026-09-17 | 39,283 | $26.88 | $1.06M | 181,349 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER, Dir | M Exercise deriv | 2026-09-15 | 2026-09-17 | 95,666 | — | $0 | 304,334 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER, Dir | S Sale | 2026-09-15 | 2026-09-17 | 270 | $65.31 | $17.6K | 432,886 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER, Dir | S Sale | 2026-09-15 | 2026-09-17 | 3,102 | $63.64 | $197.4K | 433,156 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER, Dir | S Sale | 2026-09-15 | 2026-09-17 | 28,796 | $62.66 | $1.80M | 436,258 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER, Dir | S Sale | 2026-09-15 | 2026-09-17 | 63,498 | $61.99 | $3.94M | 465,054 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER, Dir | M Exercise | 2026-09-15 | 2026-09-17 | 95,666 | $23.34 | $2.23M | 528,552 | SEC↗ |
| Cline Christopher R. | CHIEF FINANCIAL OFFICER | M Exercise deriv | 2026-09-15 | 2026-09-17 | 20,000 | — | $0 | 0 | SEC↗ |
| Cline Christopher R. | CHIEF FINANCIAL OFFICER | S Sale | 2026-09-15 | 2026-09-17 | 400 | $65.31 | $26.1K | 87,508 | SEC↗ |
| Cline Christopher R. | CHIEF FINANCIAL OFFICER | S Sale | 2026-09-15 | 2026-09-17 | 1,900 | $63.69 | $121.0K | 87,908 | SEC↗ |
| Cline Christopher R. | CHIEF FINANCIAL OFFICER | S Sale | 2026-09-15 | 2026-09-17 | 20,735 | $62.61 | $1.30M | 89,808 | SEC↗ |
| Cline Christopher R. | CHIEF FINANCIAL OFFICER | S Sale | 2026-09-15 | 2026-09-17 | 27,473 | $62.00 | $1.70M | 110,543 | SEC↗ |
| Cline Christopher R. | CHIEF FINANCIAL OFFICER | M Exercise | 2026-09-15 | 2026-09-17 | 20,000 | $17.44 | $348.8K | 138,016 | SEC↗ |
| Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICE | M Exercise deriv | 2026-09-15 | 2026-09-17 | 1,625 | — | $0 | 17,875 | SEC↗ |
| Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICE | M Exercise deriv | 2026-09-15 | 2026-09-17 | 1,250 | — | $0 | 3,750 | SEC↗ |
| Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICE | M Exercise deriv | 2026-09-15 | 2026-09-17 | 2,500 | — | $0 | 0 | SEC↗ |
| Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICE | S Sale | 2026-09-15 | 2026-09-17 | 300 | $63.66 | $19.1K | 42,353 | SEC↗ |
| Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICE | S Sale | 2026-09-15 | 2026-09-17 | 800 | $62.85 | $50.3K | 42,653 | SEC↗ |
| Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICE | S Sale | 2026-09-15 | 2026-09-17 | 4,275 | $62.13 | $265.6K | 43,453 | SEC↗ |
| Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICE | M Exercise | 2026-09-15 | 2026-09-17 | 1,625 | $20.46 | $33.2K | 47,728 | SEC↗ |
| Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICE | M Exercise | 2026-09-15 | 2026-09-17 | 1,250 | $22.40 | $28.0K | 46,103 | SEC↗ |
| Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICE | M Exercise | 2026-09-15 | 2026-09-17 | 2,500 | $27.50 | $68.8K | 44,853 | SEC↗ |
| Meckler Jeffrey A | Director | M Exercise deriv | 2026-09-10 | 2026-09-11 | 10,000 | — | $0 | 0 | SEC↗ |
| Meckler Jeffrey A | Director | M Exercise deriv | 2026-09-10 | 2026-09-11 | 10,000 | — | $0 | 0 | SEC↗ |
| Meckler Jeffrey A | Director | S Sale | 2026-09-10 | 2026-09-11 | 1,700 | $65.39 | $111.2K | 109,800 | SEC↗ |
| Meckler Jeffrey A | Director | M Exercise | 2026-09-10 | 2026-09-11 | 10,000 | $17.44 | $174.4K | 101,500 | SEC↗ |
| Meckler Jeffrey A | Director | M Exercise | 2026-09-10 | 2026-09-11 | 10,000 | $26.52 | $265.2K | 111,500 | SEC↗ |
| Meckler Jeffrey A | Director | S Sale | 2026-09-10 | 2026-09-11 | 1,200 | $66.15 | $79.4K | 108,600 | SEC↗ |
| Meckler Jeffrey A | Director | S Sale | 2026-09-10 | 2026-09-11 | 14,000 | $67.46 | $944.4K | 94,600 | SEC↗ |
| Meckler Jeffrey A | Director | S Sale | 2026-09-10 | 2026-09-11 | 3,100 | $68.09 | $211.1K | 91,500 | SEC↗ |
| Meckler Jeffrey A | Director | M Exercise deriv | 2026-09-10 | 2026-09-11 | 10,000 | — | $0 | 0 | SEC↗ |
| Meckler Jeffrey A | Director | M Exercise deriv | 2026-09-10 | 2026-09-11 | 10,000 | — | $0 | 0 | SEC↗ |
| Meckler Jeffrey A | Director | S Sale | 2026-09-10 | 2026-09-11 | 3,100 | $68.09 | $211.1K | 91,500 | SEC↗ |
| Meckler Jeffrey A | Director | S Sale | 2026-09-10 | 2026-09-11 | 14,000 | $67.46 | $944.5K | 94,600 | SEC↗ |
| Meckler Jeffrey A | Director | S Sale | 2026-09-10 | 2026-09-11 | 1,200 | $66.15 | $79.4K | 108,600 | SEC↗ |
| Meckler Jeffrey A | Director | S Sale | 2026-09-10 | 2026-09-11 | 1,700 | $65.39 | $111.2K | 109,800 | SEC↗ |
| Meckler Jeffrey A | Director | M Exercise | 2026-09-10 | 2026-09-11 | 10,000 | $26.52 | $265.2K | 111,500 | SEC↗ |
| Meckler Jeffrey A | Director | M Exercise | 2026-09-10 | 2026-09-11 | 10,000 | $17.44 | $174.4K | 101,500 | SEC↗ |
| Cline Christopher R. | CHIEF FINANCIAL OFFICER | S Sale | 2026-09-02 | 2026-09-03 | 642 | $66.37 | $42.6K | 118,016 | SEC↗ |
| Cline Christopher R. | CHIEF FINANCIAL OFFICER | S Sale | 2026-09-02 | 2026-09-03 | 642 | $66.37 | $42.6K | 118,016 | SEC↗ |
| LYONS GARY A | Director | M Exercise deriv | 2026-08-18 | 2026-08-19 | 5,000 | — | $0 | 0 | SEC↗ |
| LYONS GARY A | Director | S Sale | 2026-08-18 | 2026-08-19 | 4,100 | $63.27 | $259.4K | 62,400 | SEC↗ |
| LYONS GARY A | Director | S Sale | 2026-08-18 | 2026-08-19 | 900 | $63.86 | $57.5K | 61,500 | SEC↗ |
| LYONS GARY A | Director | M Exercise | 2026-08-18 | 2026-08-19 | 5,000 | $17.44 | $87.2K | 66,500 | SEC↗ |
| LYONS GARY A | Director | M Exercise deriv | 2026-08-18 | 2026-08-19 | 5,000 | — | $0 | 0 | SEC↗ |
| LYONS GARY A | Director | S Sale | 2026-08-18 | 2026-08-19 | 900 | $63.86 | $57.5K | 61,500 | SEC↗ |
| LYONS GARY A | Director | S Sale | 2026-08-18 | 2026-08-19 | 4,100 | $63.27 | $259.4K | 62,400 | SEC↗ |
| LYONS GARY A | Director | M Exercise | 2026-08-18 | 2026-08-19 | 5,000 | $17.44 | $87.2K | 66,500 | SEC↗ |
| LYONS GARY A | Director | M Exercise deriv | 2026-08-17 | 2026-08-19 | 5,000 | — | $0 | 5,000 | SEC↗ |
| LYONS GARY A | Director | S Sale | 2026-08-17 | 2026-08-19 | 500 | $64.16 | $32.1K | 61,500 | SEC↗ |
| LYONS GARY A | Director | S Sale | 2026-08-17 | 2026-08-19 | 2,600 | $63.50 | $165.1K | 62,000 | SEC↗ |
| LYONS GARY A | Director | S Sale | 2026-08-17 | 2026-08-19 | 1,900 | $62.53 | $118.8K | 64,600 | SEC↗ |
| LYONS GARY A | Director | M Exercise | 2026-08-17 | 2026-08-19 | 5,000 | $17.44 | $87.2K | 66,500 | SEC↗ |
| LYONS GARY A | Director | M Exercise deriv | 2026-08-17 | 2026-08-19 | 5,000 | — | $0 | 5,000 | SEC↗ |
| LYONS GARY A | Director | S Sale | 2026-08-17 | 2026-08-19 | 500 | $64.16 | $32.1K | 61,500 | SEC↗ |
| LYONS GARY A | Director | S Sale | 2026-08-17 | 2026-08-19 | 2,600 | $63.50 | $165.1K | 62,000 | SEC↗ |
| LYONS GARY A | Director | S Sale | 2026-08-17 | 2026-08-19 | 1,900 | $62.53 | $118.8K | 64,600 | SEC↗ |
| LYONS GARY A | Director | M Exercise | 2026-08-17 | 2026-08-19 | 5,000 | $17.44 | $87.2K | 66,500 | SEC↗ |
| Inrig Jula | CHIEF MEDICAL OFFICER | G Gift | 2026-06-22 | 2026-06-22 | 468 | — | $0 | 112,770 | SEC↗ |
| Baynes Roy D. | Director | M Exercise deriv | 2026-06-12 | 2026-06-16 | 4,500 | — | $0 | 0 | SEC↗ |
| Coughlin Timothy | Director | M Exercise deriv | 2026-06-12 | 2026-06-16 | 10,000 | — | $0 | 0 | SEC↗ |
| Baynes Roy D. | Director | M Exercise | 2026-06-12 | 2026-06-16 | 4,500 | $21.38 | $96.2K | 46,000 | SEC↗ |
| Baynes Roy D. | Director | S Sale | 2026-06-12 | 2026-06-16 | 4,500 | $50.00 | $225.0K | 41,500 | SEC↗ |
| Coughlin Timothy | Director | S Sale | 2026-06-12 | 2026-06-16 | 10,000 | $50.07 | $500.7K | 56,250 | SEC↗ |
| Coughlin Timothy | Director | M Exercise | 2026-06-12 | 2026-06-16 | 10,000 | $26.52 | $265.2K | 66,250 | SEC↗ |
| Baynes Roy D. | Director | A Award deriv | 2026-05-19 | 2026-05-21 | 12,000 | — | $0 | 12,000 | SEC↗ |
| Bruhn Suzanne Louise | Director | A Award deriv | 2026-05-19 | 2026-05-21 | 12,000 | — | $0 | 12,000 | SEC↗ |
| Coughlin Timothy | Director | A Award deriv | 2026-05-19 | 2026-05-21 | 12,000 | — | $0 | 12,000 | SEC↗ |
| LYONS GARY A | Director | A Award deriv | 2026-05-19 | 2026-05-21 | 12,000 | — | $0 | 12,000 | SEC↗ |
| Meckler Jeffrey A | Director | A Award deriv | 2026-05-19 | 2026-05-21 | 12,000 | — | $0 | 12,000 | SEC↗ |
| Orwin John A | Director | A Award deriv | 2026-05-19 | 2026-05-21 | 12,000 | — | $0 | 12,000 | SEC↗ |
| Poole Sandra | Director | A Award deriv | 2026-05-19 | 2026-05-21 | 12,000 | — | $0 | 12,000 | SEC↗ |
| Squarer Ron | Director | A Award deriv | 2026-05-19 | 2026-05-21 | 12,000 | — | $0 | 12,000 | SEC↗ |
| Williams Brinkley Ruth | Director | A Award deriv | 2026-05-19 | 2026-05-21 | 12,000 | — | $0 | 12,000 | SEC↗ |
| Baynes Roy D. | Director | A Award | 2026-05-19 | 2026-05-21 | 4,000 | — | $0 | 41,500 | SEC↗ |
| Bruhn Suzanne Louise | Director | A Award | 2026-05-19 | 2026-05-21 | 4,000 | — | $0 | 32,750 | SEC↗ |
| Coughlin Timothy | Director | A Award | 2026-05-19 | 2026-05-21 | 4,000 | — | $0 | 56,250 | SEC↗ |
| LYONS GARY A | Director | A Award | 2026-05-19 | 2026-05-21 | 4,000 | — | $0 | 61,500 | SEC↗ |
| Meckler Jeffrey A | Director | A Award | 2026-05-19 | 2026-05-21 | 4,000 | — | $0 | 91,500 | SEC↗ |
| Orwin John A | Director | A Award | 2026-05-19 | 2026-05-21 | 4,000 | — | $0 | 39,375 | SEC↗ |
| Poole Sandra | Director | A Award | 2026-05-19 | 2026-05-21 | 4,000 | — | $0 | 34,000 | SEC↗ |
| Squarer Ron | Director | A Award | 2026-05-19 | 2026-05-21 | 4,000 | — | $0 | 39,375 | SEC↗ |
| Williams Brinkley Ruth | Director | A Award | 2026-05-19 | 2026-05-21 | 4,000 | — | $0 | 29,750 | SEC↗ |
| Coughlin Timothy | Director | S Sale | 2026-05-15 | 2026-05-19 | 3,250 | $43.49 | $141.3K | 52,250 | SEC↗ |
| Cline Christopher R. | CHIEF FINANCIAL OFFICER | S Sale | 2026-05-06 | 2026-05-06 | 310 | $43.95 | $13.6K | 118,658 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER | S Sale | 2026-05-06 | 2026-05-06 | 22,500 | $43.95 | $988.9K | 432,886 | SEC↗ |
| Inrig Jula | CHIEF MEDICAL OFFICER | S Sale | 2026-05-06 | 2026-05-06 | 311 | $43.95 | $13.7K | 113,238 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | S Sale | 2026-05-06 | 2026-05-06 | 2,076 | $43.95 | $91.2K | 105,211 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | S Sale | 2026-05-06 | 2026-05-06 | 2,763 | $43.95 | $121.4K | 115,474 | SEC↗ |
| Baynes Roy D. | Director | M Exercise deriv | 2026-05-05 | 2026-05-06 | 4,500 | — | $0 | 0 | SEC↗ |
| Cline Christopher R. | CHIEF FINANCIAL OFFICER | S Sale | 2026-05-05 | 2026-05-06 | 2,181 | $46.65 | $101.7K | 118,968 | SEC↗ |
| Heerma Peter | CHIEF COMMERCIAL OFFICER | S Sale | 2026-05-05 | 2026-05-06 | 2,174 | $46.65 | $101.4K | 140,684 | SEC↗ |
| Inrig Jula | CHIEF MEDICAL OFFICER | S Sale | 2026-05-05 | 2026-05-06 | 2,174 | $46.65 | $101.4K | 113,549 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | S Sale | 2026-05-05 | 2026-05-06 | 2,174 | $46.65 | $101.4K | 107,287 | SEC↗ |
| Baynes Roy D. | Director | S Sale | 2026-05-05 | 2026-05-06 | 4,500 | $46.65 | $209.9K | 37,500 | SEC↗ |
| Baynes Roy D. | Director | M Exercise | 2026-05-05 | 2026-05-06 | 4,500 | $18.27 | $82.2K | 42,000 | SEC↗ |
| Cline Christopher R. | CHIEF FINANCIAL OFFICER | M Exercise deriv | 2026-05-04 | 2026-05-06 | 4,250 | — | $0 | 4,250 | SEC↗ |
| Cline Christopher R. | CHIEF FINANCIAL OFFICER | A Award deriv | 2026-05-04 | 2026-05-06 | 8,500 | — | $0 | 8,500 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER | A Award deriv | 2026-05-04 | 2026-05-06 | 45,000 | — | $0 | 45,000 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER | M Exercise deriv | 2026-05-04 | 2026-05-06 | 22,500 | — | $0 | 22,500 | SEC↗ |
| Heerma Peter | CHIEF COMMERCIAL OFFICER | M Exercise deriv | 2026-05-04 | 2026-05-06 | 4,250 | — | $0 | 4,250 | SEC↗ |
| Heerma Peter | CHIEF COMMERCIAL OFFICER | A Award deriv | 2026-05-04 | 2026-05-06 | 8,500 | — | $0 | 8,500 | SEC↗ |
| Inrig Jula | CHIEF MEDICAL OFFICER | A Award deriv | 2026-05-04 | 2026-05-06 | 8,500 | — | $0 | 8,500 | SEC↗ |
| Inrig Jula | CHIEF MEDICAL OFFICER | M Exercise deriv | 2026-05-04 | 2026-05-06 | 4,250 | — | $0 | 4,250 | SEC↗ |
| Inrig Jula | CHIEF MEDICAL OFFICER | M Exercise deriv | 2026-05-04 | 2026-05-06 | 20,000 | — | $0 | 34,500 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | A Award deriv | 2026-05-04 | 2026-05-06 | 8,500 | — | $0 | 8,500 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | M Exercise deriv | 2026-05-04 | 2026-05-06 | 4,250 | — | $0 | 4,250 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | M Exercise deriv | 2026-05-04 | 2026-05-06 | 20,000 | — | $0 | 0 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | M Exercise deriv | 2026-05-04 | 2026-05-06 | 4,250 | — | $0 | 4,250 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | A Award deriv | 2026-05-04 | 2026-05-06 | 8,500 | — | $0 | 8,500 | SEC↗ |
| Meckler Jeffrey A | Director | M Exercise deriv | 2026-05-04 | 2026-05-06 | 8,000 | — | $0 | 0 | SEC↗ |
| Cline Christopher R. | CHIEF FINANCIAL OFFICER | M Exercise | 2026-05-04 | 2026-05-06 | 4,250 | — | $0 | 121,149 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER | M Exercise | 2026-05-04 | 2026-05-06 | 22,500 | — | $0 | 455,386 | SEC↗ |
| Heerma Peter | CHIEF COMMERCIAL OFFICER | M Exercise | 2026-05-04 | 2026-05-06 | 4,250 | — | $0 | 142,858 | SEC↗ |
| Inrig Jula | CHIEF MEDICAL OFFICER | S Sale | 2026-05-04 | 2026-05-06 | 20,000 | $45.00 | $900.0K | 111,473 | SEC↗ |
| Inrig Jula | CHIEF MEDICAL OFFICER | M Exercise | 2026-05-04 | 2026-05-06 | 20,000 | $22.40 | $448.0K | 131,473 | SEC↗ |
| Inrig Jula | CHIEF MEDICAL OFFICER | M Exercise | 2026-05-04 | 2026-05-06 | 4,250 | — | $0 | 115,723 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | M Exercise | 2026-05-04 | 2026-05-06 | 20,000 | $17.96 | $359.2K | 125,211 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | S Sale | 2026-05-04 | 2026-05-06 | 20,000 | $45.00 | $900.0K | 105,211 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | M Exercise | 2026-05-04 | 2026-05-06 | 4,250 | — | $0 | 109,461 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | M Exercise | 2026-05-04 | 2026-05-06 | 4,250 | — | $0 | 118,237 | SEC↗ |
| Meckler Jeffrey A | Director | S Sale | 2026-05-04 | 2026-05-06 | 8,000 | $45.00 | $360.0K | 87,500 | SEC↗ |
| Meckler Jeffrey A | Director | M Exercise | 2026-05-04 | 2026-05-06 | 8,000 | $16.33 | $130.6K | 95,500 | SEC↗ |
| Baynes Roy D. | Director | M Exercise deriv | 2026-05-01 | 2026-05-04 | 9,750 | — | $0 | 9,750 | SEC↗ |
| Baynes Roy D. | Director | M Exercise | 2026-05-01 | 2026-05-04 | 9,750 | $6.82 | $66.5K | 47,250 | SEC↗ |
| Baynes Roy D. | Director | S Sale | 2026-05-01 | 2026-05-04 | 9,750 | $44.22 | $431.1K | 37,500 | SEC↗ |
| ROTE WILLIAM E. | Chief Research Officer | S Sale | 2026-04-22 | 2026-04-23 | 9,100 | $39.09 | $355.7K | 113,987 | SEC↗ |
| Inrig Jula | CHIEF MEDICAL OFFICER | S Sale | 2026-04-15 | 2026-04-15 | 1,018 | $42.61 | $43.4K | 111,473 | SEC↗ |
| Cline Christopher R. | CHIEF FINANCIAL OFFICER | S Sale | 2026-04-15 | 2026-04-15 | 1,014 | $42.61 | $43.2K | 116,899 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | S Sale | 2026-04-15 | 2026-04-15 | 5,226 | $41.62 | $217.5K | 106,770 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | S Sale | 2026-04-15 | 2026-04-15 | 1,559 | $42.53 | $66.3K | 105,211 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER | S Sale | 2026-04-15 | 2026-04-15 | 7,165 | $41.75 | $299.1K | 432,906 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER | S Sale | 2026-04-15 | 2026-04-15 | 20 | $42.66 | $853 | 432,886 | SEC↗ |
| Dube Eric M | CHIEF EXECUTIVE OFFICER | S Sale | 2026-04-15 | 2026-04-15 | 56,815 | $41.01 | $2.33M | 440,071 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | M Exercise deriv | 2026-04-14 | 2026-04-15 | 20,000 | — | $0 | 20,000 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | M Exercise deriv | 2026-04-14 | 2026-04-15 | 10,000 | — | $0 | 0 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | M Exercise deriv | 2026-04-14 | 2026-04-15 | 7,500 | — | $0 | 37,500 | SEC↗ |
| Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICE | M Exercise deriv | 2026-04-14 | 2026-04-16 | 6,500 | — | $0 | 19,500 | SEC↗ |
| Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICE | M Exercise deriv | 2026-04-14 | 2026-04-16 | 6,250 | — | $0 | 12,500 | SEC↗ |
| Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICE | M Exercise deriv | 2026-04-14 | 2026-04-16 | 2,500 | — | $0 | 5,000 | SEC↗ |
| Baynes Roy D. | Director | M Exercise deriv | 2026-04-14 | 2026-04-16 | 8,000 | — | $0 | 0 | SEC↗ |
| Baynes Roy D. | Director | M Exercise deriv | 2026-04-14 | 2026-04-16 | 9,000 | — | $0 | 0 | SEC↗ |
| Baynes Roy D. | Director | M Exercise deriv | 2026-04-14 | 2026-04-16 | 4,500 | — | $0 | 4,500 | SEC↗ |
| Baynes Roy D. | Director | M Exercise deriv | 2026-04-14 | 2026-04-16 | 4,500 | — | $0 | 4,500 | SEC↗ |
| Baynes Roy D. | Director | M Exercise deriv | 2026-04-14 | 2026-04-16 | 6,750 | — | $0 | 6,750 | SEC↗ |
| LYONS GARY A | Director | M Exercise deriv | 2026-04-14 | 2026-04-16 | 8,000 | — | $0 | 0 | SEC↗ |
| Inrig Jula | CHIEF MEDICAL OFFICER | S Sale | 2026-04-14 | 2026-04-15 | 7,215 | $41.93 | $302.5K | 112,491 | SEC↗ |
| Cline Christopher R. | CHIEF FINANCIAL OFFICER | S Sale | 2026-04-14 | 2026-04-15 | 9 | $41.07 | $370 | 125,152 | SEC↗ |
| Cline Christopher R. | CHIEF FINANCIAL OFFICER | S Sale | 2026-04-14 | 2026-04-15 | 7,239 | $41.93 | $303.5K | 117,913 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | M Exercise | 2026-04-14 | 2026-04-15 | 20,000 | $17.96 | $359.2K | 149,211 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | M Exercise | 2026-04-14 | 2026-04-15 | 10,000 | $19.08 | $190.8K | 129,211 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | M Exercise | 2026-04-14 | 2026-04-15 | 7,500 | $15.46 | $116.0K | 156,711 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | S Sale | 2026-04-14 | 2026-04-15 | 7,215 | $41.93 | $302.5K | 111,996 | SEC↗ |
| REED ELIZABETH E | Chief Legal Officer and GC | S Sale | 2026-04-14 | 2026-04-15 | 37,500 | $41.07 | $1.54M | 119,211 | SEC↗ |
| Heerma Peter | CHIEF COMMERCIAL OFFICER | S Sale | 2026-04-14 | 2026-04-15 | 7,215 | $41.93 | $302.5K | 138,608 | SEC↗ |
| Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICE | S Sale | 2026-04-14 | 2026-04-16 | 21,977 | $41.07 | $902.6K | 42,353 | SEC↗ |
| Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICE | M Exercise | 2026-04-14 | 2026-04-16 | 6,500 | $20.46 | $133.0K | 64,330 | SEC↗ |
| Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICE | M Exercise | 2026-04-14 | 2026-04-16 | 2,500 | $22.40 | $56.0K | 51,580 | SEC↗ |
| Calvin Sandra | SVP, CHIEF ACCOUNTING OFFICE | M Exercise | 2026-04-14 | 2026-04-16 | 6,250 | $8.93 | $55.8K | 57,830 | SEC↗ |