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UPB

Upstream Bio, Inc.CIK 2022626 ☆ Sign in to watchCongress trades
Open-mkt buys · 90d
—
0 trades · 0 insiders
Open-mkt sales · 90d
$55.2K
10 trades · 5 insiders
Net · 90d
$-55.2K
Insiders on file
14

AI insights for UPB PRO

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AI insights for UPB
Insider sentiment score with a plain-English explanation, conviction score on every buy, and how the stock performed 30 and 90 days after past insider buys.
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Daily buy vs sell · 90 days

$55.2K2026-09-16 buys — 2026-09-16 sales $55.2K09-16
■ Open-market buys (P)   ■ Open-market sales (S) · daily dollar value by transaction date

Insiders

InsiderRoleTradesBoughtSoldLast trade
Ambrose AllisonGeneral Counsel8$0$12.6K2026-09-16
Deykin AaronChief Medical Officer7$0$23.6K2026-09-16
Houghton AdamChief Business Officer7$0$18.4K2026-09-16
Sutherland Everett RandChief Executive Officer, Director7$0$55.2K2026-09-16
GRAY MICHAELCFO and COO7$0$22.5K2026-09-16
Ruddy Marcella K.Director3$0$02026-06-09
Fleming Harold EdwardDirector3$0$02026-06-09
Chimovits ErezDirector, 10% Owner11$14.03M$02026-06-09
Ratcliffe LiamDirector3$0$02026-06-09
Beckman DaniellaDirector3$0$02026-06-09
Renaud Ronald C JRDirector3$0$02026-06-09
Wellington Biomedical Innovation Master Investors (Cayman) II L.P.10% Owner2$0$02024-10-15
Access Industries Holdings LLC10% Owner5$19.98M$02024-10-15
ORBIMED ADVISORS LLCDirector, 10% Owner8$14.03M$02024-10-15

Trade history

InsiderRoleCodeTradeFiledSharesPriceValueOwned after
Ambrose AllisonGeneral Counsel S Sale2026-09-162026-09-17485$5.49 $2.7K15,563SEC↗
GRAY MICHAELCFO and COO S Sale2026-09-162026-09-17853$5.49 $4.7K27,942SEC↗
Houghton AdamChief Business Officer S Sale2026-09-162026-09-17700$5.49 $3.8K22,901SEC↗
Sutherland Everett RandChief Executive Officer S Sale2026-09-162026-09-172,095$5.49 $11.5K68,717SEC↗
Deykin AaronChief Medical Officer S Sale2026-09-162026-09-17895$5.49 $4.9K32,302SEC↗
Sutherland Everett RandChief Executive Officer, Dir S Sale2026-09-162026-09-172,095$5.49 $11.5K68,717SEC↗
Houghton AdamChief Business Officer S Sale2026-09-162026-09-17700$5.49 $3.8K22,901SEC↗
GRAY MICHAELCFO and COO S Sale2026-09-162026-09-17853$5.49 $4.7K27,942SEC↗
Deykin AaronChief Medical Officer S Sale2026-09-162026-09-17895$5.49 $4.9K32,302SEC↗
Ambrose AllisonGeneral Counsel S Sale2026-09-162026-09-17485$5.49 $2.7K15,563SEC↗
Ambrose AllisonGeneral Counsel S Sale2026-06-162026-06-17477$6.10 $2.9K16,048SEC↗
Deykin AaronChief Medical Officer S Sale2026-06-162026-06-17895$6.10 $5.5K33,197SEC↗
Houghton AdamChief Business Officer S Sale2026-06-162026-06-17700$6.10 $4.3K23,601SEC↗
Sutherland Everett RandChief Executive Officer S Sale2026-06-162026-06-172,095$6.10 $12.8K70,812SEC↗
GRAY MICHAELCFO and COO S Sale2026-06-162026-06-17853$6.10 $5.2K28,795SEC↗
Chimovits ErezDirector A Award deriv2026-06-092026-06-1117,096— $017,096SEC↗
Ratcliffe LiamDirector A Award deriv2026-06-092026-06-1117,096— $017,096SEC↗
Beckman DaniellaDirector A Award deriv2026-06-092026-06-1117,096— $017,096SEC↗
Fleming Harold EdwardDirector A Award deriv2026-06-092026-06-1117,096— $017,096SEC↗
Renaud Ronald C JRDirector A Award deriv2026-06-092026-06-1117,096— $017,096SEC↗
Ruddy Marcella K.Director A Award deriv2026-06-092026-06-1117,096— $017,096SEC↗
Houghton AdamChief Business Officer S Sale2026-03-162026-03-17699$9.29 $6.5K24,301SEC↗
Ambrose AllisonGeneral Counsel S Sale2026-03-162026-03-17475$9.29 $4.4K16,525SEC↗
Sutherland Everett RandChief Executive Officer S Sale2026-03-162026-03-172,093$9.29 $19.4K72,907SEC↗
Deykin AaronChief Medical Officer S Sale2026-03-162026-03-17894$9.29 $8.3K32,687SEC↗
GRAY MICHAELCFO and COO S Sale2026-03-162026-03-17852$9.29 $7.9K29,648SEC↗
Sutherland Everett RandChief Executive Officer A Award deriv2026-01-022026-01-06225,000— $0225,000SEC↗
Houghton AdamChief Business Officer A Award deriv2026-01-022026-01-0675,000— $075,000SEC↗
Ambrose AllisonGeneral Counsel A Award deriv2026-01-022026-01-0651,000— $051,000SEC↗
Deykin AaronChief Medical Officer A Award deriv2026-01-022026-01-0696,000— $096,000SEC↗
GRAY MICHAELCFO and COO A Award deriv2026-01-022026-01-0691,500— $091,500SEC↗
Sutherland Everett RandChief Executive Officer A Award2026-01-022026-01-0675,000— $075,000SEC↗
Houghton AdamChief Business Officer A Award2026-01-022026-01-0625,000— $025,000SEC↗
Ambrose AllisonGeneral Counsel A Award2026-01-022026-01-0617,000— $017,000SEC↗
Deykin AaronChief Medical Officer A Award2026-01-022026-01-0632,000— $033,581SEC↗
GRAY MICHAELCFO and COO A Award2026-01-022026-01-0630,500— $030,500SEC↗
Ratcliffe LiamDirector A Award deriv2025-06-102025-06-1217,096— $017,096SEC↗
Fleming Harold EdwardDirector A Award deriv2025-06-102025-06-1217,096— $017,096SEC↗
Chimovits ErezDirector A Award deriv2025-06-102025-06-1217,096— $017,096SEC↗
Renaud Ronald C JRDirector A Award deriv2025-06-102025-06-1217,096— $017,096SEC↗
Beckman DaniellaDirector A Award deriv2025-06-102025-06-1217,096— $017,096SEC↗
Ruddy Marcella K.Director A Award deriv2025-06-102025-06-1217,096— $017,096SEC↗
Ambrose AllisonGeneral Counsel A Award deriv2025-02-062025-02-0725,000— $025,000SEC↗
Deykin AaronChief Medical Officer A Award deriv2025-02-062025-02-07165,000— $0165,000SEC↗
Houghton AdamChief Business Officer A Award deriv2025-02-062025-02-07140,000— $0140,000SEC↗
GRAY MICHAELCFO and COO A Award deriv2025-02-062025-02-07195,000— $0195,000SEC↗
Sutherland Everett RandChief Executive Officer A Award deriv2025-02-062025-02-07500,000— $0500,000SEC↗
Ambrose AllisonGeneral Counsel A Award deriv2024-12-162024-12-17100,000— $0100,000SEC↗
Wellington Biomedical Innovati10% Owner C Conversion deriv2024-10-152024-10-15852,940— $00SEC↗
Access Industries Holdings LLC10% Owner C Conversion deriv2024-10-152024-10-171,172,410— $00SEC↗
Access Industries Holdings LLC10% Owner C Conversion deriv2024-10-152024-10-173,147,000— $00SEC↗
ORBIMED ADVISORS LLCDirector, 10% Owner C Conversion deriv2024-10-152024-10-17524,500— $00SEC↗
ORBIMED ADVISORS LLCDirector, 10% Owner C Conversion deriv2024-10-152024-10-172,098,000— $00SEC↗
ORBIMED ADVISORS LLCDirector, 10% Owner C Conversion deriv2024-10-152024-10-17197,456— $00SEC↗
ORBIMED ADVISORS LLCDirector, 10% Owner C Conversion deriv2024-10-152024-10-17789,833— $00SEC↗
Chimovits ErezDirector, 10% Owner C Conversion deriv2024-10-152024-10-17789,833— $00SEC↗
Chimovits ErezDirector, 10% Owner C Conversion deriv2024-10-152024-10-17524,500— $00SEC↗
Chimovits ErezDirector, 10% Owner C Conversion deriv2024-10-152024-10-172,098,000— $00SEC↗
Chimovits ErezDirector, 10% Owner C Conversion deriv2024-10-152024-10-17197,456— $00SEC↗
Wellington Biomedical Innovati10% Owner C Conversion2024-10-152024-10-15894,733— $0894,733SEC↗
Access Industries Holdings LLC10% Owner C Conversion2024-10-152024-10-171,172,410— $05,494,410SEC↗
Access Industries Holdings LLC10% Owner C Conversion2024-10-152024-10-173,147,000— $04,322,000SEC↗
Access Industries Holdings LLC10% Owner P Buy2024-10-152024-10-171,175,000$17.00 $19.98M1,175,000SEC↗
ORBIMED ADVISORS LLCDirector, 10% Owner P Buy2024-10-152024-10-17660,000$17.00 $11.22M4,554,873SEC↗
ORBIMED ADVISORS LLCDirector, 10% Owner C Conversion2024-10-152024-10-17721,956— $0973,716SEC↗
ORBIMED ADVISORS LLCDirector, 10% Owner P Buy2024-10-152024-10-17165,000$17.00 $2.81M1,138,716SEC↗
ORBIMED ADVISORS LLCDirector, 10% Owner C Conversion2024-10-152024-10-172,887,833— $03,894,873SEC↗
Chimovits ErezDirector, 10% Owner P Buy2024-10-152024-10-17660,000$17.00 $11.22M4,554,873SEC↗
Chimovits ErezDirector, 10% Owner C Conversion2024-10-152024-10-172,887,833— $03,894,873SEC↗
Chimovits ErezDirector, 10% Owner P Buy2024-10-152024-10-17165,000$17.00 $2.81M1,138,716SEC↗
Chimovits ErezDirector, 10% Owner C Conversion2024-10-152024-10-17721,956— $0973,716SEC↗
Ratcliffe LiamDirector A Award deriv2024-10-102024-10-1517,096— $017,096SEC↗
Fleming Harold EdwardDirector A Award deriv2024-10-102024-10-1517,096— $017,096SEC↗
Ruddy Marcella K.Director A Award deriv2024-10-102024-10-1517,096— $017,096SEC↗
Chimovits ErezDirector A Award deriv2024-10-102024-10-1517,096— $017,096SEC↗
Beckman DaniellaDirector A Award deriv2024-10-102024-10-1534,681— $034,681SEC↗
Renaud Ronald C JRDirector A Award deriv2024-10-102024-10-1517,096— $017,096SEC↗