Open-mkt buys · 90d
—
0 trades · 0 insiders
Open-mkt sales · 90d
—
0 trades · 0 insiders
Net · 90d
$0
Insiders on file
40
Daily buy vs sell · 90 days
No data yet.
Insiders
| Insider | Role | Trades | Bought | Sold | Last trade |
|---|---|---|---|---|---|
| Ferrell Karen E. | Director | 1 | $0 | $0 | 2020-02-20 |
| Plutzky Jorge MD | Director | 39 | $0 | $0 | 2020-02-20 |
| Norton David Y | Director | 38 | $0 | $0 | 2020-02-20 |
| KING THOMAS BRAXTON | Interim Chief Executive Office | 5 | $0 | $0 | 2020-02-20 |
| ROSENMAN HERM | Director | 45 | $159.0K | $0 | 2020-02-20 |
| KANGAS EDWARD A | Director | 1 | $0 | $0 | 2020-02-20 |
| Amos John P. | Chief Executive Officer | 14 | $1.14M | $1.2K | 2020-01-29 |
| Varghese Santosh T | VP, Medical & Reg Affairs | 26 | $0 | $71.7K | 2020-01-29 |
| Oki Mark K | SVP, CFO, CAO | 11 | $40.7K | $0 | 2020-01-29 |
| Slebir John L | VP, General Counsel | 30 | $0 | $357.6K | 2020-01-29 |
| Roberts Eric W | Director | 102 | $41.0K | $0 | 2019-02-28 |
| Suh Kenneth | President | 1 | $0 | $0 | 2019-01-23 |
| Oehrlein M. Scott | Chief Operations Officer | 4 | $0 | $0 | 2019-01-23 |
| Shaw Allan | Director | 103 | $0 | $0 | 2018-10-26 |
| Fischer Seth H.Z. | Other | 11 | $18.7K | $0 | 2018-01-01 |
| North Tide Capital Master, LP | 10% Owner | 44 | $4.76M | $1.79M | 2017-03-10 |
| Laughlin Conan | Director, 10% Owner | 14 | $603.5K | $589.6K | 2017-03-07 |
| NORTH TIDE CAPITAL, LLC | 10% Owner | 16 | $492.8K | $1.12M | 2017-03-02 |
| Sris Mayu | Other | 35 | $0 | $0 | 2017-01-16 |
| DENNER ALEXANDER J | Director | 5 | $4.87M | $0 | 2015-10-30 |
| Sanford Svai S | Interim CFO | 7 | $0 | $1.3K | 2015-08-03 |
| Day Wesley | VP, Clinical Research | 26 | $0 | $2.54M | 2015-07-01 |
| MARSH GUY P | VP, US Operations & GM | 43 | $0 | $4.11M | 2015-01-29 |
| Colin Samuel F | Director, 10% Owner | 2 | $0 | $0 | 2014-05-01 |
| MORRIS TIMOTHY E | VP, Finance and CFO | 40 | $0 | $7.89M | 2013-09-05 |
| ASTRUE MICHAEL J | Director | 2 | $119.6K | $0 | 2013-09-04 |
| JOHANNES JACOB PIETER KASTELEIN | Director | 1 | $0 | $0 | 2013-08-14 |
| CARROLL J MARTIN | Director | 2 | $0 | $0 | 2013-08-14 |
| LOGAN MARK B | Director | 28 | $0 | $1.83M | 2013-08-14 |
| WILSON ROBERT N | Director | 2 | $0 | $0 | 2013-08-14 |
| Zook Anthony P. | Chief Executive Officer | 1 | $0 | $0 | 2013-07-25 |
| BIRO JON C | 10% Owner | 1 | $25.7K | $0 | 2013-06-27 |
| MARIO ERNEST | Director | 6 | $758.9K | $0 | 2013-05-29 |
| Perry Lee | VP & Chief Accounting Officer | 56 | $0 | $5.86M | 2013-01-25 |
| SHORTLIFFE LINDA M DAIRIKI | Director | 45 | $0 | $2.50M | 2013-01-25 |
| TAM PETER Y | President | 61 | $0 | $9.81M | 2013-01-25 |
| MILLER MICHAEL PATRICK | Chief Commercial Officer | 13 | $0 | $2.09M | 2013-01-25 |
| CASAMENTO CHARLES J | Director | 23 | $0 | $910.2K | 2013-01-25 |
| WILSON LELAND F | Chief Executive Officer | 37 | $0 | $10.05M | 2013-01-25 |
| MILLER MICHAEL /NY/ | Chief Commercial Officer | 2 | $0 | $0 | 2012-01-27 |
Trade history
| Insider | Role | Code | Trade | Filed | Shares | Price | Value | Owned after | |
|---|---|---|---|---|---|---|---|---|---|
| Ferrell Karen E. | Director | A Award deriv | 2020-02-20 | 2020-02-24 | 15,000 | — | $0 | 15,000 | SEC↗ |
| KANGAS EDWARD A | Director | A Award deriv | 2020-02-20 | 2020-02-24 | 15,000 | — | $0 | 15,000 | SEC↗ |
| KING THOMAS BRAXTON | Director | A Award deriv | 2020-02-20 | 2020-02-24 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Norton David Y | Director | A Award deriv | 2020-02-20 | 2020-02-24 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Plutzky Jorge MD | Director | A Award deriv | 2020-02-20 | 2020-02-24 | 15,000 | — | $0 | 15,000 | SEC↗ |
| ROSENMAN HERM | Director | A Award deriv | 2020-02-20 | 2020-02-24 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Varghese Santosh T | Chief Medical Officer | A Award deriv | 2020-01-29 | 2020-01-31 | 32,000 | — | $0 | 32,000 | SEC↗ |
| Slebir John L | SVP, Business Development & | A Award deriv | 2020-01-29 | 2020-01-31 | 32,000 | — | $0 | 32,000 | SEC↗ |
| Oki Mark K | Chief Financial Officer & CA | A Award deriv | 2020-01-29 | 2020-01-31 | 32,000 | — | $0 | 32,000 | SEC↗ |
| Amos John P. | Chief Executive Officer | A Award deriv | 2020-01-29 | 2020-01-31 | 137,500 | — | $0 | 137,500 | SEC↗ |
| Varghese Santosh T | Chief Medical Officer | A Award | 2019-11-14 | 2019-11-18 | 700 | $2.38 | $1.7K | 9,242 | SEC↗ |
| Oki Mark K | SVP, CFO, CAO | A Award | 2019-11-14 | 2019-11-18 | 700 | $2.38 | $1.7K | 12,100 | SEC↗ |
| Varghese Santosh T | Chief Medical Officer | A Award | 2019-05-14 | 2019-05-15 | 700 | $2.84 | $2.0K | 8,542 | SEC↗ |
| Oki Mark K | SVP, CFO, CAO | A Award | 2019-05-14 | 2019-05-15 | 700 | $2.84 | $2.0K | 11,400 | SEC↗ |
| Amos John P. | Chief Executive Officer | P Buy | 2019-03-01 | 2019-04-10 | 11,000 | $4.85 | $53.3K | 181,850 | SEC↗ |
| Amos John P. | Chief Executive Officer | P Buy | 2019-03-01 | 2019-03-04 | 11,000 | $4.85 | $53.3K | 1,719,500 | SEC↗ |
| Roberts Eric W | Director | P Buy | 2019-02-28 | 2019-03-04 | 8,500 | $4.82 | $41.0K | 16,660 | SEC↗ |
| Amos John P. | Chief Executive Officer | A Award deriv | 2019-01-23 | 2019-01-25 | 137,500 | — | $0 | 137,500 | SEC↗ |
| Suh Kenneth | President | A Award deriv | 2019-01-23 | 2019-01-25 | 85,000 | — | $0 | 85,000 | SEC↗ |
| Slebir John L | SVP, Business Development & | A Award deriv | 2019-01-23 | 2019-01-25 | 32,000 | — | $0 | 32,000 | SEC↗ |
| Oehrlein M. Scott | Chief Operations Officer | A Award deriv | 2019-01-23 | 2019-01-25 | 31,000 | — | $0 | 31,000 | SEC↗ |
| Oki Mark K | Chief Financial Officer & CA | A Award deriv | 2019-01-23 | 2019-01-25 | 32,000 | — | $0 | 32,000 | SEC↗ |
| Varghese Santosh T | Chief Medical Officer | A Award deriv | 2019-01-23 | 2019-01-25 | 32,000 | — | $0 | 32,000 | SEC↗ |
| Oki Mark K | Chief Financial Officer & CA | A Award | 2018-11-14 | 2018-11-16 | 700 | $2.71 | $1.9K | 10,700 | SEC↗ |
| Varghese Santosh T | Chief Medical Officer | A Award | 2018-11-14 | 2018-11-16 | 700 | $2.71 | $1.9K | 7,842 | SEC↗ |
| Oki Mark K | Chief Financial Officer & CA | P Buy | 2018-11-06 | 2018-11-07 | 10,000 | $4.07 | $40.7K | 10,000 | SEC↗ |
| Norton David Y | Director | A Award deriv | 2018-10-26 | 2018-10-29 | 15,000 | — | $0 | 15,000 | SEC↗ |
| KING THOMAS BRAXTON | Director | A Award deriv | 2018-10-26 | 2018-10-29 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Plutzky Jorge MD | Director | A Award deriv | 2018-10-26 | 2018-10-29 | 15,000 | — | $0 | 15,000 | SEC↗ |
| ROSENMAN HERM | Director | A Award deriv | 2018-10-26 | 2018-10-29 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Shaw Allan | Director | A Award deriv | 2018-10-26 | 2018-10-29 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Roberts Eric W | Director | A Award deriv | 2018-10-26 | 2018-10-29 | 15,000 | — | $0 | 15,000 | SEC↗ |
| Roberts Eric W | Director | M Exercise | 2018-10-01 | 2018-10-03 | 139 | — | $0 | 8,203 | SEC↗ |
| Roberts Eric W | Director | F Tax w/h | 2018-10-01 | 2018-10-03 | 43 | $5.63 | $242 | 8,160 | SEC↗ |
| Shaw Allan | Director | F Tax w/h | 2018-10-01 | 2018-10-03 | 43 | $5.63 | $242 | 6,389 | SEC↗ |
| Shaw Allan | Director | M Exercise | 2018-10-01 | 2018-10-03 | 139 | — | $0 | 6,432 | SEC↗ |
| Shaw Allan | Director | M Exercise deriv | 2018-09-15 | 2018-09-18 | 139 | — | $0 | 139 | SEC↗ |
| Roberts Eric W | Director | M Exercise deriv | 2018-09-15 | 2018-09-18 | 139 | — | $0 | 139 | SEC↗ |
| Roberts Eric W | Director | M Exercise deriv | 2018-08-15 | 2018-08-16 | 1,389 | — | $0 | 2,778 | SEC↗ |
| Shaw Allan | Director | M Exercise deriv | 2018-08-15 | 2018-08-16 | 1,389 | — | $0 | 2,778 | SEC↗ |
| Roberts Eric W | Director | F Tax w/h | 2018-08-15 | 2018-08-16 | 438 | $0.63 | $276 | 80,632 | SEC↗ |
| Roberts Eric W | Director | M Exercise | 2018-08-15 | 2018-08-16 | 1,389 | — | $0 | 81,070 | SEC↗ |
| Shaw Allan | Director | M Exercise | 2018-08-15 | 2018-08-16 | 1,389 | — | $0 | 63,366 | SEC↗ |
| Shaw Allan | Director | F Tax w/h | 2018-08-15 | 2018-08-16 | 438 | $0.63 | $276 | 62,928 | SEC↗ |
| Shaw Allan | Director | M Exercise deriv | 2018-07-15 | 2018-07-17 | 1,389 | — | $0 | 4,167 | SEC↗ |
| Roberts Eric W | Director | M Exercise deriv | 2018-07-15 | 2018-07-17 | 1,389 | — | $0 | 4,167 | SEC↗ |
| Shaw Allan | Director | F Tax w/h | 2018-07-15 | 2018-07-17 | 439 | $0.77 | $338 | 61,977 | SEC↗ |
| Shaw Allan | Director | M Exercise | 2018-07-15 | 2018-07-17 | 1,389 | — | $0 | 62,416 | SEC↗ |
| Roberts Eric W | Director | M Exercise | 2018-07-15 | 2018-07-17 | 1,389 | — | $0 | 80,120 | SEC↗ |
| Roberts Eric W | Director | F Tax w/h | 2018-07-15 | 2018-07-17 | 439 | $0.77 | $338 | 79,681 | SEC↗ |
| ROSENMAN HERM | Director | M Exercise deriv | 2018-06-29 | 2018-07-03 | 25,000 | — | $0 | 50,000 | SEC↗ |
| ROSENMAN HERM | Director | M Exercise | 2018-06-29 | 2018-07-03 | 25,000 | $0.70 | $17.5K | 311,671 | SEC↗ |
| KING THOMAS BRAXTON | Director | A Award deriv | 2018-06-15 | 2018-06-19 | 200,000 | — | $0 | 200,000 | SEC↗ |
| Roberts Eric W | Director | M Exercise deriv | 2018-06-15 | 2018-06-19 | 1,389 | — | $0 | 5,556 | SEC↗ |
| Shaw Allan | Director | A Award deriv | 2018-06-15 | 2018-06-19 | 100,000 | — | $0 | 100,000 | SEC↗ |
| Shaw Allan | Director | M Exercise deriv | 2018-06-15 | 2018-06-19 | 1,389 | — | $0 | 5,556 | SEC↗ |
| Roberts Eric W | Director | F Tax w/h | 2018-06-15 | 2018-06-19 | 438 | $0.84 | $368 | 78,731 | SEC↗ |
| Roberts Eric W | Director | M Exercise | 2018-06-15 | 2018-06-19 | 1,389 | — | $0 | 79,169 | SEC↗ |
| Shaw Allan | Director | F Tax w/h | 2018-06-15 | 2018-06-19 | 438 | $0.84 | $368 | 61,027 | SEC↗ |
| Shaw Allan | Director | M Exercise | 2018-06-15 | 2018-06-19 | 1,389 | — | $0 | 61,465 | SEC↗ |
| ROSENMAN HERM | Director | P Buy | 2018-06-01 | 2018-06-05 | 50,000 | $0.77 | $38.5K | 50,000 | SEC↗ |
| ROSENMAN HERM | Director | P Buy | 2018-05-29 | 2018-05-31 | 50,000 | $0.79 | $39.5K | 286,671 | SEC↗ |
| ROSENMAN HERM | Director | M Exercise deriv | 2018-05-21 | 2018-05-23 | 75,000 | — | $0 | 75,000 | SEC↗ |
| ROSENMAN HERM | Director | M Exercise | 2018-05-21 | 2018-05-23 | 75,000 | $0.70 | $52.5K | 136,671 | SEC↗ |
| ROSENMAN HERM | Director | P Buy | 2018-05-21 | 2018-05-23 | 100,000 | $0.81 | $81.0K | 236,671 | SEC↗ |
| Amos John P. | Chief Executive Officer | P Buy | 2018-05-18 | 2018-05-22 | 270,000 | $0.77 | $207.9K | 1,710,000 | SEC↗ |
| Amos John P. | Chief Executive Officer | S Sale | 2018-05-18 | 2018-05-22 | 1,500 | $0.77 | $1.2K | 1,708,500 | SEC↗ |
| Amos John P. | Chief Executive Officer | P Buy | 2018-05-17 | 2018-05-21 | 360,000 | $0.69 | $248.4K | 1,440,000 | SEC↗ |
| Amos John P. | Chief Executive Officer | P Buy | 2018-05-16 | 2018-05-17 | 270,000 | $0.58 | $156.6K | 1,080,000 | SEC↗ |
| Roberts Eric W | Director | M Exercise deriv | 2018-05-15 | 2018-05-17 | 1,389 | — | $0 | 6,945 | SEC↗ |
| Shaw Allan | Director | M Exercise deriv | 2018-05-15 | 2018-05-17 | 1,389 | — | $0 | 6,945 | SEC↗ |
| Amos John P. | Chief Executive Officer | P Buy | 2018-05-15 | 2018-05-17 | 270,000 | $0.54 | $145.8K | 810,000 | SEC↗ |
| Roberts Eric W | Director | M Exercise | 2018-05-15 | 2018-05-17 | 1,389 | — | $0 | 78,277 | SEC↗ |
| Roberts Eric W | Director | D To issuer | 2018-05-15 | 2018-05-17 | 497 | $0.52 | $258 | 77,780 | SEC↗ |
| Shaw Allan | Director | D To issuer | 2018-05-15 | 2018-05-17 | 438 | $0.52 | $228 | 60,076 | SEC↗ |
| Shaw Allan | Director | M Exercise | 2018-05-15 | 2018-05-17 | 1,389 | — | $0 | 60,514 | SEC↗ |
| Amos John P. | Chief Executive Officer | P Buy | 2018-05-14 | 2018-05-15 | 270,000 | $0.51 | $137.7K | 540,000 | SEC↗ |
| Amos John P. | Chief Executive Officer | P Buy | 2018-05-11 | 2018-05-15 | 270,000 | $0.52 | $140.4K | 270,000 | SEC↗ |
| Amos John P. | Chief Executive Officer | A Award deriv | 2018-04-30 | 2018-08-09 | 995,000 | $0.37 | $368.1K | 995,000 | SEC↗ |
| Oehrlein M. Scott | Chief Operations Officer | A Award deriv | 2018-04-30 | 2018-08-09 | 239,000 | $0.37 | $88.4K | 239,000 | SEC↗ |
| Amos John P. | Chief Executive Officer | A Award deriv | 2018-04-30 | 2018-05-02 | 2,700,000 | — | $0 | 2,700,000 | SEC↗ |
| Amos John P. | Chief Executive Officer | A Award deriv | 2018-04-30 | 2018-05-02 | 200,000 | — | $0 | 200,000 | SEC↗ |
| Slebir John L | SVP, Business Development & | A Award deriv | 2018-04-30 | 2018-05-02 | 200,000 | — | $0 | 200,000 | SEC↗ |
| Oki Mark K | Chief Financial Officer & CA | A Award deriv | 2018-04-30 | 2018-05-02 | 200,000 | — | $0 | 200,000 | SEC↗ |
| Oehrlein M. Scott | Chief Operations Officer | A Award deriv | 2018-04-30 | 2018-05-02 | 620,000 | — | $0 | 620,000 | SEC↗ |
| Oehrlein M. Scott | Chief Operations Officer | A Award deriv | 2018-04-30 | 2018-05-02 | 200,000 | — | $0 | 200,000 | SEC↗ |
| Roberts Eric W | Director | M Exercise deriv | 2018-04-15 | 2018-04-17 | 1,389 | — | $0 | 8,334 | SEC↗ |
| Shaw Allan | Director | M Exercise deriv | 2018-04-15 | 2018-04-17 | 1,389 | — | $0 | 8,334 | SEC↗ |
| Roberts Eric W | Director | D To issuer | 2018-04-15 | 2018-04-17 | 438 | $0.42 | $184 | 76,888 | SEC↗ |
| Roberts Eric W | Director | M Exercise | 2018-04-15 | 2018-04-17 | 1,389 | — | $0 | 77,326 | SEC↗ |
| Shaw Allan | Director | D To issuer | 2018-04-15 | 2018-04-17 | 438 | $0.42 | $184 | 59,125 | SEC↗ |
| Shaw Allan | Director | M Exercise | 2018-04-15 | 2018-04-17 | 1,389 | — | $0 | 59,563 | SEC↗ |
| Varghese Santosh T | Chief Medical Officer | S Sale | 2018-04-03 | 2018-04-04 | 390 | $0.34 | $133 | 71,415 | SEC↗ |
| Slebir John L | SVP, Business Development & | D To issuer | 2018-04-01 | 2018-04-03 | 559 | $0.36 | $201 | 134,010 | SEC↗ |
| Roberts Eric W | Director | M Exercise deriv | 2018-03-15 | 2018-03-19 | 1,389 | — | $0 | 9,723 | SEC↗ |
| Shaw Allan | Director | M Exercise deriv | 2018-03-15 | 2018-03-19 | 1,389 | — | $0 | 9,723 | SEC↗ |
| Roberts Eric W | Director | D To issuer | 2018-03-15 | 2018-03-19 | 438 | $0.48 | $210 | 75,937 | SEC↗ |
| Roberts Eric W | Director | M Exercise | 2018-03-15 | 2018-03-19 | 1,389 | — | $0 | 76,375 | SEC↗ |
| Shaw Allan | Director | M Exercise | 2018-03-15 | 2018-03-19 | 1,389 | — | $0 | 58,612 | SEC↗ |
| Shaw Allan | Director | D To issuer | 2018-03-15 | 2018-03-19 | 438 | $0.48 | $210 | 58,174 | SEC↗ |
| Shaw Allan | Director | A Award deriv | 2018-03-09 | 2018-03-13 | 300,000 | — | $0 | 300,000 | SEC↗ |
| Roberts Eric W | Director | M Exercise deriv | 2018-02-15 | 2018-02-20 | 1,389 | — | $0 | 11,112 | SEC↗ |
| Shaw Allan | Director | M Exercise deriv | 2018-02-15 | 2018-02-20 | 1,389 | — | $0 | 11,112 | SEC↗ |
| Roberts Eric W | Director | D To issuer | 2018-02-15 | 2018-02-20 | 497 | $0.46 | $229 | 74,986 | SEC↗ |
| Roberts Eric W | Director | M Exercise | 2018-02-15 | 2018-02-20 | 1,389 | — | $0 | 75,483 | SEC↗ |
| Shaw Allan | Director | M Exercise | 2018-02-15 | 2018-02-20 | 1,389 | — | $0 | 57,661 | SEC↗ |
| Shaw Allan | Director | D To issuer | 2018-02-15 | 2018-02-20 | 438 | $0.46 | $201 | 57,223 | SEC↗ |
| Oki Mark K | Chief Financial Officer & CA | A Award deriv | 2018-02-02 | 2018-02-06 | 350,000 | — | $0 | 350,000 | SEC↗ |
| Slebir John L | SVP, Business Development & | A Award deriv | 2018-02-02 | 2018-02-06 | 425,000 | — | $0 | 425,000 | SEC↗ |
| Varghese Santosh T | Chief Medical Officer | A Award deriv | 2018-02-02 | 2018-02-06 | 262,500 | — | $0 | 262,500 | SEC↗ |
| Varghese Santosh T | Chief Medical Officer | S Sale | 2018-01-31 | 2018-02-01 | 491 | $0.43 | $211 | 71,805 | SEC↗ |
| Slebir John L | SVP, Business Development & | D To issuer | 2018-01-28 | 2018-01-30 | 614 | $0.46 | $282 | 134,569 | SEC↗ |
| KING THOMAS BRAXTON | Interim Chief Executive Offi | A Award deriv | 2018-01-26 | 2018-01-30 | 600,000 | — | $0 | 600,000 | SEC↗ |
| Roberts Eric W | Director | M Exercise deriv | 2018-01-15 | 2018-01-17 | 1,389 | — | $0 | 12,501 | SEC↗ |
| Shaw Allan | Director | M Exercise deriv | 2018-01-15 | 2018-01-17 | 1,389 | — | $0 | 12,501 | SEC↗ |
| Roberts Eric W | Director | D To issuer | 2018-01-15 | 2018-01-17 | 539 | $0.51 | $275 | 74,094 | SEC↗ |
| Roberts Eric W | Director | M Exercise | 2018-01-15 | 2018-01-17 | 1,389 | — | $0 | 74,633 | SEC↗ |
| Shaw Allan | Director | M Exercise | 2018-01-15 | 2018-01-17 | 1,389 | — | $0 | 56,752 | SEC↗ |
| Shaw Allan | Director | D To issuer | 2018-01-15 | 2018-01-17 | 480 | $0.51 | $245 | 56,272 | SEC↗ |
| Slebir John L | SVP, Business Development & | D To issuer | 2018-01-01 | 2018-01-03 | 710 | $0.50 | $355 | 135,183 | SEC↗ |
| Varghese Santosh T | Chief Medical Officer | S Sale | 2018-01-01 | 2018-01-03 | 444 | $0.51 | $226 | 72,296 | SEC↗ |
| Fischer Seth H. Z. | Other | D To issuer | 2018-01-01 | 2018-01-03 | 2,102 | $0.50 | $1.1K | 633,978 | SEC↗ |
| Roberts Eric W | Director | M Exercise deriv | 2017-12-15 | 2017-12-19 | 1,389 | — | $0 | 13,890 | SEC↗ |
| Shaw Allan | Director | M Exercise deriv | 2017-12-15 | 2017-12-19 | 1,389 | — | $0 | 13,890 | SEC↗ |
| Roberts Eric W | Director | D To issuer | 2017-12-15 | 2017-12-19 | 540 | $0.53 | $286 | 73,244 | SEC↗ |
| Roberts Eric W | Director | M Exercise | 2017-12-15 | 2017-12-19 | 1,389 | — | $0 | 73,784 | SEC↗ |
| Shaw Allan | Director | M Exercise | 2017-12-15 | 2017-12-19 | 1,389 | — | $0 | 55,844 | SEC↗ |
| Shaw Allan | Director | D To issuer | 2017-12-15 | 2017-12-19 | 481 | $0.53 | $255 | 55,363 | SEC↗ |
| Roberts Eric W | Director | M Exercise deriv | 2017-11-15 | 2017-11-17 | 1,389 | — | $0 | 15,279 | SEC↗ |
| Shaw Allan | Director | M Exercise deriv | 2017-11-15 | 2017-11-17 | 1,389 | — | $0 | 15,279 | SEC↗ |
| Roberts Eric W | Director | D To issuer | 2017-11-15 | 2017-11-17 | 540 | $0.66 | $356 | 72,395 | SEC↗ |
| Roberts Eric W | Director | M Exercise | 2017-11-15 | 2017-11-17 | 1,389 | — | $0 | 72,935 | SEC↗ |
| Shaw Allan | Director | M Exercise | 2017-11-15 | 2017-11-17 | 1,389 | — | $0 | 54,936 | SEC↗ |
| Shaw Allan | Director | D To issuer | 2017-11-15 | 2017-11-17 | 481 | $0.66 | $317 | 54,455 | SEC↗ |
| Norton David Y | Director | A Award deriv | 2017-10-27 | 2017-10-31 | 150,000 | — | $0 | 150,000 | SEC↗ |
| Norton David Y | Director | M Exercise deriv | 2017-10-27 | 2017-10-31 | 12,500 | — | $0 | 0 | SEC↗ |
| Plutzky Jorge MD | Director | A Award deriv | 2017-10-27 | 2017-10-31 | 150,000 | — | $0 | 150,000 | SEC↗ |
| Plutzky Jorge MD | Director | M Exercise deriv | 2017-10-27 | 2017-10-31 | 12,500 | — | $0 | 0 | SEC↗ |
| Roberts Eric W | Director | M Exercise deriv | 2017-10-27 | 2017-10-31 | 12,500 | — | $0 | 0 | SEC↗ |
| Roberts Eric W | Director | A Award deriv | 2017-10-27 | 2017-10-31 | 150,000 | — | $0 | 150,000 | SEC↗ |
| ROSENMAN HERM | Director | A Award deriv | 2017-10-27 | 2017-10-31 | 150,000 | — | $0 | 150,000 | SEC↗ |
| ROSENMAN HERM | Director | M Exercise deriv | 2017-10-27 | 2017-10-31 | 12,500 | — | $0 | 0 | SEC↗ |
| Shaw Allan | Director | A Award deriv | 2017-10-27 | 2017-10-31 | 150,000 | — | $0 | 150,000 | SEC↗ |
| Shaw Allan | Director | M Exercise deriv | 2017-10-27 | 2017-10-31 | 12,500 | — | $0 | 0 | SEC↗ |
| Norton David Y | Director | D To issuer | 2017-10-27 | 2017-10-31 | 3,125 | $0.70 | $2.2K | 67,120 | SEC↗ |
| Norton David Y | Director | M Exercise | 2017-10-27 | 2017-10-31 | 12,500 | — | $0 | 70,245 | SEC↗ |
| Plutzky Jorge MD | Director | M Exercise | 2017-10-27 | 2017-10-31 | 12,500 | — | $0 | 84,921 | SEC↗ |
| Plutzky Jorge MD | Director | D To issuer | 2017-10-27 | 2017-10-31 | 3,762 | $0.70 | $2.6K | 81,159 | SEC↗ |
| Roberts Eric W | Director | D To issuer | 2017-10-27 | 2017-10-31 | 4,859 | $0.70 | $3.4K | 71,546 | SEC↗ |
| Roberts Eric W | Director | M Exercise | 2017-10-27 | 2017-10-31 | 12,500 | — | $0 | 76,405 | SEC↗ |
| ROSENMAN HERM | Director | M Exercise | 2017-10-27 | 2017-10-31 | 12,500 | — | $0 | 66,074 | SEC↗ |
| ROSENMAN HERM | Director | D To issuer | 2017-10-27 | 2017-10-31 | 4,403 | $0.70 | $3.1K | 61,671 | SEC↗ |
| Shaw Allan | Director | M Exercise | 2017-10-27 | 2017-10-31 | 12,500 | — | $0 | 57,874 | SEC↗ |
| Shaw Allan | Director | D To issuer | 2017-10-27 | 2017-10-31 | 4,327 | $0.70 | $3.0K | 53,547 | SEC↗ |
| Shaw Allan | Director | D To issuer | 2017-10-16 | 2017-10-17 | 480 | $0.86 | $413 | 45,374 | SEC↗ |
| Roberts Eric W | Director | D To issuer | 2017-10-16 | 2017-10-17 | 540 | $0.86 | $464 | 63,905 | SEC↗ |
| Shaw Allan | Director | M Exercise deriv | 2017-10-15 | 2017-10-17 | 1,389 | — | $0 | 16,668 | SEC↗ |
| Roberts Eric W | Director | M Exercise deriv | 2017-10-15 | 2017-10-17 | 1,389 | — | $0 | 16,668 | SEC↗ |
| Shaw Allan | Director | M Exercise | 2017-10-15 | 2017-10-17 | 1,389 | — | $0 | 45,854 | SEC↗ |
| Roberts Eric W | Director | M Exercise | 2017-10-15 | 2017-10-17 | 1,389 | — | $0 | 64,445 | SEC↗ |
| Varghese Santosh T | Chief Medical Officer | S Sale | 2017-10-03 | 2017-10-04 | 434 | $0.97 | $421 | 72,740 | SEC↗ |
| Roberts Eric W | Director | M Exercise deriv | 2017-09-15 | 2017-09-19 | 1,389 | — | $0 | 18,057 | SEC↗ |
| Shaw Allan | Director | M Exercise deriv | 2017-09-15 | 2017-09-19 | 1,389 | — | $0 | 18,057 | SEC↗ |
| Roberts Eric W | Director | M Exercise | 2017-09-15 | 2017-09-19 | 1,389 | — | $0 | 63,596 | SEC↗ |
| Roberts Eric W | Director | D To issuer | 2017-09-15 | 2017-09-19 | 540 | $1.00 | $540 | 63,056 | SEC↗ |
| Shaw Allan | Director | D To issuer | 2017-09-15 | 2017-09-19 | 481 | $1.00 | $481 | 44,465 | SEC↗ |
| Shaw Allan | Director | M Exercise | 2017-09-15 | 2017-09-19 | 1,389 | — | $0 | 44,946 | SEC↗ |
| Roberts Eric W | Director | M Exercise deriv | 2017-08-15 | 2017-08-17 | 1,388 | — | $0 | 19,446 | SEC↗ |
| Shaw Allan | Director | M Exercise deriv | 2017-08-15 | 2017-08-17 | 1,388 | — | $0 | 19,446 | SEC↗ |
| Roberts Eric W | Director | M Exercise | 2017-08-15 | 2017-08-17 | 1,388 | — | $0 | 62,746 | SEC↗ |
| Roberts Eric W | Director | D To issuer | 2017-08-15 | 2017-08-17 | 539 | $1.01 | $544 | 62,207 | SEC↗ |
| Shaw Allan | Director | D To issuer | 2017-08-15 | 2017-08-17 | 480 | $1.01 | $485 | 43,557 | SEC↗ |
| Shaw Allan | Director | M Exercise | 2017-08-15 | 2017-08-17 | 1,388 | — | $0 | 44,037 | SEC↗ |
| Norton David Y | Director | M Exercise deriv | 2017-08-08 | 2017-08-10 | 12,500 | — | $0 | 12,500 | SEC↗ |
| Plutzky Jorge MD | Director | M Exercise deriv | 2017-08-08 | 2017-08-10 | 12,500 | — | $0 | 12,500 | SEC↗ |
| Roberts Eric W | Director | M Exercise deriv | 2017-08-08 | 2017-08-10 | 12,500 | — | $0 | 12,500 | SEC↗ |
| ROSENMAN HERM | Director | M Exercise deriv | 2017-08-08 | 2017-08-10 | 12,500 | — | $0 | 12,500 | SEC↗ |
| Shaw Allan | Director | M Exercise deriv | 2017-08-08 | 2017-08-10 | 12,500 | — | $0 | 12,500 | SEC↗ |
| Norton David Y | Director | D To issuer | 2017-08-08 | 2017-08-10 | 3,125 | $1.01 | $3.2K | 57,745 | SEC↗ |
| Norton David Y | Director | M Exercise | 2017-08-08 | 2017-08-10 | 12,500 | — | $0 | 60,870 | SEC↗ |
| Plutzky Jorge MD | Director | M Exercise | 2017-08-08 | 2017-08-10 | 12,500 | — | $0 | 76,183 | SEC↗ |
| Plutzky Jorge MD | Director | D To issuer | 2017-08-08 | 2017-08-10 | 3,762 | $1.01 | $3.8K | 72,421 | SEC↗ |
| Roberts Eric W | Director | D To issuer | 2017-08-08 | 2017-08-10 | 4,859 | $1.01 | $4.9K | 61,358 | SEC↗ |
| Roberts Eric W | Director | M Exercise | 2017-08-08 | 2017-08-10 | 12,500 | — | $0 | 66,217 | SEC↗ |
| ROSENMAN HERM | Director | M Exercise | 2017-08-08 | 2017-08-10 | 12,500 | — | $0 | 57,977 | SEC↗ |
| ROSENMAN HERM | Director | D To issuer | 2017-08-08 | 2017-08-10 | 4,403 | $1.01 | $4.4K | 53,574 | SEC↗ |
| Shaw Allan | Director | M Exercise | 2017-08-08 | 2017-08-10 | 12,500 | — | $0 | 46,976 | SEC↗ |
| Shaw Allan | Director | D To issuer | 2017-08-08 | 2017-08-10 | 4,327 | $1.01 | $4.4K | 42,649 | SEC↗ |
| KING THOMAS BRAXTON | Director | A Award deriv | 2017-07-27 | 2017-07-31 | 125,000 | — | $0 | 125,000 | SEC↗ |
| Shaw Allan | Director | M Exercise deriv | 2017-07-15 | 2017-07-18 | 1,389 | — | $0 | 20,834 | SEC↗ |
| Roberts Eric W | Director | M Exercise deriv | 2017-07-15 | 2017-07-18 | 1,389 | — | $0 | 20,834 | SEC↗ |
| Shaw Allan | Director | M Exercise | 2017-07-15 | 2017-07-18 | 1,389 | — | $0 | 34,957 | SEC↗ |
| Shaw Allan | Director | D To issuer | 2017-07-15 | 2017-07-18 | 481 | $1.27 | $611 | 34,476 | SEC↗ |
| Roberts Eric W | Director | M Exercise | 2017-07-15 | 2017-07-18 | 1,389 | — | $0 | 54,257 | SEC↗ |
| Roberts Eric W | Director | D To issuer | 2017-07-15 | 2017-07-18 | 540 | $1.27 | $686 | 53,717 | SEC↗ |
| Varghese Santosh T | Chief Medical Officer | S Sale | 2017-07-03 | 2017-07-05 | 423 | $1.23 | $520 | 73,174 | SEC↗ |
| Roberts Eric W | Director | M Exercise deriv | 2017-06-15 | 2017-06-19 | 1,389 | — | $0 | 22,223 | SEC↗ |
| Shaw Allan | Director | M Exercise deriv | 2017-06-15 | 2017-06-19 | 1,389 | — | $0 | 22,223 | SEC↗ |
| Norton David Y | Director | D To issuer | 2017-06-15 | 2017-06-19 | 3,125 | $1.17 | $3.7K | 48,370 | SEC↗ |
| Plutzky Jorge MD | Director | D To issuer | 2017-06-15 | 2017-06-19 | 3,762 | $1.17 | $4.4K | 63,683 | SEC↗ |
| Roberts Eric W | Director | M Exercise | 2017-06-15 | 2017-06-19 | 1,389 | — | $0 | 53,407 | SEC↗ |
| Roberts Eric W | Director | D To issuer | 2017-06-15 | 2017-06-19 | 539 | $1.17 | $631 | 52,868 | SEC↗ |
| Roberts Eric W | Director | D To issuer | 2017-06-15 | 2017-06-19 | 4,859 | $1.17 | $5.7K | 52,018 | SEC↗ |
| ROSENMAN HERM | Director | D To issuer | 2017-06-15 | 2017-06-19 | 4,403 | $1.17 | $5.2K | 45,477 | SEC↗ |
| Shaw Allan | Director | D To issuer | 2017-06-15 | 2017-06-19 | 4,327 | $1.17 | $5.1K | 32,659 | SEC↗ |
| Shaw Allan | Director | M Exercise | 2017-06-15 | 2017-06-19 | 1,389 | — | $0 | 34,048 | SEC↗ |
| Shaw Allan | Director | D To issuer | 2017-06-15 | 2017-06-19 | 480 | $1.17 | $562 | 33,568 | SEC↗ |
| Norton David Y | Director | M Exercise deriv | 2017-05-08 | 2017-06-19 | 12,500 | — | $0 | 25,000 | SEC↗ |
| Plutzky Jorge MD | Director | M Exercise deriv | 2017-05-08 | 2017-06-19 | 12,500 | — | $0 | 25,000 | SEC↗ |
| Roberts Eric W | Director | M Exercise deriv | 2017-05-08 | 2017-06-19 | 12,500 | — | $0 | 25,000 | SEC↗ |
| ROSENMAN HERM | Director | M Exercise deriv | 2017-05-08 | 2017-06-19 | 12,500 | — | $0 | 25,000 | SEC↗ |
| Shaw Allan | Director | M Exercise deriv | 2017-05-08 | 2017-06-19 | 12,500 | — | $0 | 25,000 | SEC↗ |
| Norton David Y | Director | M Exercise | 2017-05-08 | 2017-06-19 | 12,500 | — | $0 | 51,495 | SEC↗ |
| Plutzky Jorge MD | Director | M Exercise | 2017-05-08 | 2017-06-19 | 12,500 | — | $0 | 67,445 | SEC↗ |
| Roberts Eric W | Director | M Exercise | 2017-05-08 | 2017-06-19 | 12,500 | — | $0 | 56,877 | SEC↗ |
| ROSENMAN HERM | Director | M Exercise | 2017-05-08 | 2017-06-19 | 12,500 | — | $0 | 49,880 | SEC↗ |
| Shaw Allan | Director | M Exercise | 2017-05-08 | 2017-06-19 | 12,500 | — | $0 | 36,986 | SEC↗ |
| Roberts Eric W | Director | M Exercise deriv | 2017-04-15 | 2017-04-18 | 1,389 | — | $0 | 23,612 | SEC↗ |
| Shaw Allan | Director | M Exercise deriv | 2017-04-15 | 2017-04-18 | 1,389 | — | $0 | 23,612 | SEC↗ |
| Roberts Eric W | Director | D To issuer | 2017-04-15 | 2017-04-18 | 540 | $1.03 | $556 | 44,377 | SEC↗ |
| Roberts Eric W | Director | M Exercise | 2017-04-15 | 2017-04-18 | 1,389 | — | $0 | 44,917 | SEC↗ |
| Shaw Allan | Director | M Exercise | 2017-04-15 | 2017-04-18 | 1,389 | — | $0 | 24,967 | SEC↗ |
| Shaw Allan | Director | D To issuer | 2017-04-15 | 2017-04-18 | 481 | $1.03 | $495 | 24,486 | SEC↗ |
| Varghese Santosh T | Chief Medical Officer | S Sale | 2017-04-04 | 2017-04-06 | 440 | $1.08 | $475 | 73,597 | SEC↗ |
| Shaw Allan | Director | M Exercise deriv | 2017-03-15 | 2017-03-17 | 1,389 | — | $0 | 25,001 | SEC↗ |
| Roberts Eric W | Director | M Exercise deriv | 2017-03-15 | 2017-03-17 | 1,389 | — | $0 | 25,001 | SEC↗ |
| Shaw Allan | Director | D To issuer | 2017-03-15 | 2017-03-17 | 480 | $1.11 | $533 | 23,578 | SEC↗ |
| Shaw Allan | Director | M Exercise | 2017-03-15 | 2017-03-17 | 1,389 | — | $0 | 24,058 | SEC↗ |
| Roberts Eric W | Director | D To issuer | 2017-03-15 | 2017-03-17 | 539 | $1.11 | $598 | 43,528 | SEC↗ |
| Roberts Eric W | Director | M Exercise | 2017-03-15 | 2017-03-17 | 1,389 | — | $0 | 44,067 | SEC↗ |
| North Tide Capital Master, LP | 10% Owner | S Sale | 2017-03-10 | 2017-03-10 | 77,000 | $1.17 | $90.1K | 10,466,700 | SEC↗ |
| North Tide Capital Master, LP | 10% Owner | S Sale | 2017-03-09 | 2017-03-10 | 237,100 | $1.20 | $284.5K | 10,543,700 | SEC↗ |
| North Tide Capital Master, LP | 10% Owner | S Sale | 2017-03-09 | 2017-03-10 | 435,300 | $1.21 | $526.7K | 10,780,800 | SEC↗ |
| North Tide Capital Master, LP | 10% Owner | S Sale | 2017-03-09 | 2017-03-10 | 50,000 | $1.25 | $62.5K | 11,216,100 | SEC↗ |
| North Tide Capital Master, LP | 10% Owner | S Sale | 2017-03-08 | 2017-03-10 | 350,000 | $1.05 | $367.5K | 11,266,100 | SEC↗ |
| Laughlin Conan | Director, 10% Owner | S Sale | 2017-03-07 | 2017-03-07 | 105,100 | $1.07 | $112.5K | 11,656,100 | SEC↗ |
| Laughlin Conan | Director, 10% Owner | S Sale | 2017-03-07 | 2017-03-07 | 40,000 | $1.08 | $43.2K | 11,616,100 | SEC↗ |
| Laughlin Conan | Director, 10% Owner | S Sale | 2017-03-06 | 2017-03-07 | 10,000 | $1.10 | $11.0K | 11,766,000 | SEC↗ |
| Laughlin Conan | Director, 10% Owner | S Sale | 2017-03-06 | 2017-03-07 | 4,800 | $1.10 | $5.3K | 11,761,200 | SEC↗ |
| Laughlin Conan | Director, 10% Owner | S Sale | 2017-03-03 | 2017-03-07 | 31,200 | $1.11 | $34.6K | 11,776,000 | SEC↗ |
| Laughlin Conan | Director, 10% Owner | S Sale | 2017-03-03 | 2017-03-07 | 1,700 | $1.11 | $1.9K | 11,807,200 | SEC↗ |
| NORTH TIDE CAPITAL, LLC | 10% Owner | S Sale | 2017-03-02 | 2017-03-02 | 20,000 | $1.13 | $22.6K | 11,808,900 | SEC↗ |
| NORTH TIDE CAPITAL, LLC | 10% Owner | S Sale | 2017-03-01 | 2017-03-02 | 42,000 | $1.13 | $47.5K | 11,828,900 | SEC↗ |
| NORTH TIDE CAPITAL, LLC | 10% Owner | S Sale | 2017-03-01 | 2017-03-02 | 72,600 | $1.14 | $82.8K | 11,870,900 | SEC↗ |
| NORTH TIDE CAPITAL, LLC | 10% Owner | S Sale | 2017-02-28 | 2017-03-02 | 25,500 | $1.12 | $28.6K | 11,943,500 | SEC↗ |
| Laughlin Conan | Director, 10% Owner | S Sale | 2017-02-27 | 2017-02-27 | 43,000 | $1.13 | $48.6K | 11,969,000 | SEC↗ |
| Laughlin Conan | Director, 10% Owner | S Sale | 2017-02-27 | 2017-02-27 | 107,000 | $1.13 | $120.9K | 12,012,000 | SEC↗ |
| Laughlin Conan | Director, 10% Owner | S Sale | 2017-02-24 | 2017-02-27 | 33,000 | $1.14 | $37.6K | 12,119,000 | SEC↗ |
| Laughlin Conan | Director, 10% Owner | S Sale | 2017-02-23 | 2017-02-27 | 150,000 | $1.16 | $174.0K | 12,152,000 | SEC↗ |
| North Tide Capital Master, LP | 10% Owner | S Sale | 2017-02-22 | 2017-02-22 | 109,336 | $1.11 | $121.4K | 12,302,000 | SEC↗ |
| North Tide Capital Master, LP | 10% Owner | S Sale | 2017-02-21 | 2017-02-22 | 52,164 | $1.10 | $57.4K | 12,411,336 | SEC↗ |
| North Tide Capital Master, LP | 10% Owner | S Sale | 2017-02-17 | 2017-02-22 | 300 | $1.11 | $333 | 12,463,500 | SEC↗ |
| NORTH TIDE CAPITAL, LLC | 10% Owner | S Sale | 2017-02-16 | 2017-02-16 | 20,000 | $1.11 | $22.2K | 12,593,800 | SEC↗ |
| NORTH TIDE CAPITAL, LLC | 10% Owner | S Sale | 2017-02-16 | 2017-02-16 | 130,000 | $1.10 | $143.0K | 12,463,800 | SEC↗ |
| Roberts Eric W | Director | M Exercise deriv | 2017-02-15 | 2017-02-17 | 1,389 | — | $0 | 26,390 | SEC↗ |
| Shaw Allan | Director | M Exercise deriv | 2017-02-15 | 2017-02-17 | 1,389 | — | $0 | 26,390 | SEC↗ |
| NORTH TIDE CAPITAL, LLC | 10% Owner | S Sale | 2017-02-15 | 2017-02-16 | 40,090 | $1.11 | $44.5K | 12,613,800 | SEC↗ |
| Roberts Eric W | Director | D To issuer | 2017-02-15 | 2017-02-17 | 539 | $1.10 | $593 | 42,678 | SEC↗ |
| Roberts Eric W | Director | M Exercise | 2017-02-15 | 2017-02-17 | 1,389 | — | $0 | 43,217 | SEC↗ |
| Shaw Allan | Director | M Exercise | 2017-02-15 | 2017-02-17 | 1,389 | — | $0 | 23,149 | SEC↗ |
| Shaw Allan | Director | D To issuer | 2017-02-15 | 2017-02-17 | 480 | $1.10 | $528 | 22,669 | SEC↗ |
| NORTH TIDE CAPITAL, LLC | 10% Owner | S Sale | 2017-02-14 | 2017-02-16 | 115,000 | $1.10 | $126.5K | 12,653,890 | SEC↗ |
| North Tide Capital Master, LP | 10% Owner | S Sale | 2017-02-13 | 2017-02-13 | 67,000 | $1.10 | $73.7K | 12,768,890 | SEC↗ |
| North Tide Capital Master, LP | 10% Owner | S Sale | 2017-02-10 | 2017-02-13 | 46,008 | $1.11 | $51.1K | 12,835,890 | SEC↗ |
| North Tide Capital Master, LP | 10% Owner | S Sale | 2017-02-09 | 2017-02-13 | 63,402 | $1.11 | $70.4K | 12,881,898 | SEC↗ |
| Norton David Y | Director | M Exercise deriv | 2017-02-08 | 2017-02-10 | 12,500 | — | $0 | 37,500 | SEC↗ |
| Shaw Allan | Director | M Exercise deriv | 2017-02-08 | 2017-02-10 | 12,500 | — | $0 | 37,500 | SEC↗ |
| ROSENMAN HERM | Director | M Exercise deriv | 2017-02-08 | 2017-02-10 | 12,500 | — | $0 | 37,500 | SEC↗ |
| Roberts Eric W | Director | M Exercise deriv | 2017-02-08 | 2017-02-10 | 12,500 | — | $0 | 37,500 | SEC↗ |
| Plutzky Jorge MD | Director | M Exercise deriv | 2017-02-08 | 2017-02-10 | 12,500 | — | $0 | 37,500 | SEC↗ |
| NORTH TIDE CAPITAL, LLC | 10% Owner | S Sale | 2017-02-08 | 2017-02-08 | 21,251 | $1.09 | $23.2K | 12,945,300 | SEC↗ |
| NORTH TIDE CAPITAL, LLC | 10% Owner | S Sale | 2017-02-08 | 2017-02-08 | 508,049 | $1.06 | $538.5K | 12,966,551 | SEC↗ |
| Norton David Y | Director | D To issuer | 2017-02-08 | 2017-02-10 | 3,125 | $1.08 | $3.4K | 38,995 | SEC↗ |
| Norton David Y | Director | M Exercise | 2017-02-08 | 2017-02-10 | 12,500 | — | $0 | 42,120 | SEC↗ |
| Shaw Allan | Director | D To issuer | 2017-02-08 | 2017-02-10 | 4,327 | $1.08 | $4.7K | 21,760 | SEC↗ |
| Shaw Allan | Director | M Exercise | 2017-02-08 | 2017-02-10 | 12,500 | — | $0 | 26,087 | SEC↗ |
| ROSENMAN HERM | Director | D To issuer | 2017-02-08 | 2017-02-10 | 4,403 | $1.08 | $4.8K | 37,380 | SEC↗ |
| ROSENMAN HERM | Director | M Exercise | 2017-02-08 | 2017-02-10 | 12,500 | — | $0 | 41,783 | SEC↗ |
| Roberts Eric W | Director | M Exercise | 2017-02-08 | 2017-02-10 | 12,500 | — | $0 | 46,687 | SEC↗ |
| Roberts Eric W | Director | D To issuer | 2017-02-08 | 2017-02-10 | 4,859 | $1.08 | $5.2K | 41,828 | SEC↗ |
| Plutzky Jorge MD | Director | M Exercise | 2017-02-08 | 2017-02-10 | 12,500 | — | $0 | 58,707 | SEC↗ |
| Plutzky Jorge MD | Director | D To issuer | 2017-02-08 | 2017-02-10 | 3,762 | $1.08 | $4.1K | 54,945 | SEC↗ |
| NORTH TIDE CAPITAL, LLC | 10% Owner | S Sale | 2017-02-07 | 2017-02-08 | 6,200 | $1.11 | $6.9K | 13,474,600 | SEC↗ |
| NORTH TIDE CAPITAL, LLC | 10% Owner | S Sale | 2017-02-06 | 2017-02-08 | 28,027 | $1.10 | $30.8K | 13,480,800 | SEC↗ |
| North Tide Capital Master, LP | 10% Owner | S Sale | 2017-02-03 | 2017-02-03 | 53,433 | $1.12 | $59.8K | 13,508,827 | SEC↗ |
| North Tide Capital Master, LP | 10% Owner | S Sale | 2017-02-02 | 2017-02-03 | 3,200 | $1.13 | $3.6K | 13,562,260 | SEC↗ |
| North Tide Capital Master, LP | 10% Owner | S Sale | 2017-02-01 | 2017-02-03 | 21,000 | $1.13 | $23.7K | 13,565,460 | SEC↗ |
| North Tide Capital Master, LP | 10% Owner | S Sale | 2017-02-01 | 2017-02-03 | 1,000 | $1.14 | $1.1K | 13,586,460 | SEC↗ |
| Varghese Santosh T | Chief Medical Officer | S Sale | 2017-01-28 | 2017-01-31 | 429 | $1.11 | $476 | 74,037 | SEC↗ |
| Varghese Santosh T | Chief Medical Officer | A Award deriv | 2017-01-27 | 2017-01-31 | 385,000 | — | $0 | 385,000 | SEC↗ |
| Slebir John L | SVP, Business Development & | A Award deriv | 2017-01-27 | 2017-01-31 | 437,500 | — | $0 | 437,500 | SEC↗ |
| Oki Mark K | Chief Financial Officer & CA | A Award deriv | 2017-01-27 | 2017-01-31 | 385,000 | — | $0 | 385,000 | SEC↗ |
| Fischer Seth H. Z. | Chief Executive Officer | A Award deriv | 2017-01-27 | 2017-01-31 | 1,000,000 | — | $0 | 1,000,000 | SEC↗ |
| Fischer Seth H. Z. | Chief Executive Officer | A Award | 2017-01-27 | 2017-01-31 | 150,000 | — | $0 | 636,080 | SEC↗ |
| Sris Mayu | Other | D To issuer deriv | 2017-01-16 | 2017-01-18 | 27,779 | — | $0 | 0 | SEC↗ |
| Sris Mayu | Other | M Exercise deriv | 2017-01-16 | 2017-01-18 | 8,333 | — | $0 | 41,667 | SEC↗ |
| Sris Mayu | Other | D To issuer deriv | 2017-01-16 | 2017-01-18 | 41,667 | — | $0 | 0 | SEC↗ |
| Sris Mayu | Other | M Exercise | 2017-01-16 | 2017-01-18 | 8,333 | — | $0 | 25,001 | SEC↗ |
| Sris Mayu | Other | D To issuer | 2017-01-16 | 2017-01-18 | 2,083 | $1.20 | $2.5K | 22,918 | SEC↗ |
| Sris Mayu | Other | M Exercise deriv | 2017-01-15 | 2017-01-18 | 1,389 | — | $0 | 27,779 | SEC↗ |