XTNT

Xtant Medical Holdings, Inc.CIK 1453593 ☆ Sign in to watch Congress trades

Open-mkt buys · 90d

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0 trades · 0 insiders

Open-mkt sales · 90d

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0 trades · 0 insiders

Net · 90d

Insiders on file

AI insights for XTNT PRO

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AI insights for XTNT

Insider sentiment score with a plain-English explanation, conviction score on every buy, and how the stock performed 30 and 90 days after past insider buys.

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Daily buy vs sell · 90 days

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Insiders

Insider	Role	Trades	Bought	Sold	Last trade
JAIN ABHINAV	Director	3	$0	$0	2026-08-15
Beeson Jonn R.	Director	7	$0	$0	2026-08-15
Schallenberger Mark A.	Chief Operations Officer	13	$0	$0	2026-08-15
Neils Scott C	Interim Chief Financial Office	21	$0	$8.3K	2026-08-15
Browne Sean E	President and Chief Executive	21	$0	$86.1K	2026-08-15
Vizirgianakis Stavros G.	Director	11	$1.09M	$0	2026-08-15
Lipschultz Tyler	Director	3	$0	$0	2026-08-15
BAKEWELL JOHN K	Director	12	$0	$0	2026-08-15
Orbimed ROF II LLC	Director, 10% Owner	14	$0	$30.71M	2025-04-10
Brandt Kevin D	VP & Chief Commercial Officer	19	$50.0K	$11.2K	2024-08-15
McNamara Robert	Director	8	$0	$0	2024-08-15
MITCHELL-KELLER LORI D	Director	4	$0	$0	2024-08-15
Eggenberg Michael	Director, 10% Owner	32	$6.81M	$0	2022-08-15
Rizzo Matthew	Director, 10% Owner	32	$6.81M	$0	2022-08-15
Peters Jeffrey J	Director	5	$0	$0	2022-08-15
ORBIMED ADVISORS LLC	Director, 10% Owner	24	$6.81M	$0	2022-08-15
JENSEN GREG	Vice President, Finance & CFO	6	$0	$0	2021-08-15
Berlin Ronald G.	VP & Chief Operations Officer	1	$0	$0	2019-01-15
Mainelli Michael	Interim CEO	2	$0	$0	2018-10-15
Lenzen Kathie J.	Chief Financial Officer	1	$0	$0	2018-09-15
O'Connell Carl	President	2	$0	$0	2018-08-15
TIMKO ERIC BERNARD	Director	2	$0	$0	2017-07-25
Mazzocchi Rudy A	Director	2	$0	$0	2017-07-25
DEEDRICK JOHN ARTHUR	Director	4	$0	$0	2017-07-25
LOPACH MICHAEL A	Director	4	$0	$0	2017-07-25
Swanson Kent L	Director	16	$24.3K	$0	2017-07-25
BUCKMAN PAUL	Director	2	$0	$0	2017-07-25
Goldberger Daniel S	Chief Executive Officer	5	$20.1K	$0	2016-11-17
Kirschman David Louis	EVP & Chief Scientific Officer	5	$11.8K	$0	2016-07-02
WICKWIRE JON M.	Other	2	$0	$0	2016-07-01
Goodman David	Other	2	$0	$0	2016-07-01

Trade history

Insider	Role	Code	Trade	Filed	Shares	Price	Value	Owned after
Browne Sean E	President and CEO	F Tax w/h	2026-08-15	2026-08-18	10,605	$0.31	$3.3K	3,114,669	SEC↗
Browne Sean E	President and CEO	A Award	2026-08-15	2026-08-18	550,000	—	$0	3,125,274	SEC↗
Neils Scott C	CFO and Assistant Secretary	A Award	2026-08-15	2026-08-18	400,000	—	$0	1,243,381	SEC↗
Neils Scott C	CFO and Assistant Secretary	F Tax w/h	2026-08-15	2026-08-18	28,155	$0.31	$8.7K	1,215,226	SEC↗
Schallenberger Mark A.	Chief Operating Officer	F Tax w/h	2026-08-15	2026-08-18	7,070	$0.31	$2.2K	1,106,087	SEC↗
Schallenberger Mark A.	Chief Operating Officer	A Award	2026-08-15	2026-08-18	450,000	—	$0	1,113,157	SEC↗
Vizirgianakis Stavros G.	Director	A Award	2026-08-15	2026-08-18	323,275	—	$0	7,838,845	SEC↗
JAIN ABHINAV	Director	A Award	2026-08-15	2026-08-18	215,517	—	$0	373,745	SEC↗
Beeson Jonn R.	Director	A Award	2026-08-15	2026-08-18	215,517	—	$0	733,136	SEC↗
BAKEWELL JOHN K	Director	A Award	2026-08-15	2026-08-18	215,517	—	$0	1,129,633	SEC↗
Lipschultz Tyler	Director	A Award	2026-08-15	2026-08-18	215,517	—	$0	373,745	SEC↗
Vizirgianakis Stavros G.	Director	A Award	2026-08-15	2026-08-18	323,275	—	$0	7,838,845	SEC↗
Schallenberger Mark A.	Chief Operating Officer	F Tax w/h	2026-08-15	2026-08-18	7,070	$0.31	$2.2K	1,106,087	SEC↗
Schallenberger Mark A.	Chief Operating Officer	A Award	2026-08-15	2026-08-18	450,000	—	$0	1,113,157	SEC↗
Neils Scott C	CFO and Assistant Secretary	F Tax w/h	2026-08-15	2026-08-18	28,155	$0.31	$8.7K	1,215,226	SEC↗
Neils Scott C	CFO and Assistant Secretary	A Award	2026-08-15	2026-08-18	400,000	—	$0	1,243,381	SEC↗
Lipschultz Tyler	Director	A Award	2026-08-15	2026-08-18	215,517	—	$0	373,745	SEC↗
JAIN ABHINAV	Director	A Award	2026-08-15	2026-08-18	215,517	—	$0	373,745	SEC↗
Browne Sean E	President and CEO, Director	F Tax w/h	2026-08-15	2026-08-18	10,605	$0.31	$3.3K	3,114,669	SEC↗
Browne Sean E	President and CEO, Director	A Award	2026-08-15	2026-08-18	550,000	—	$0	3,125,274	SEC↗
Beeson Jonn R.	Director	A Award	2026-08-15	2026-08-18	215,517	—	$0	733,136	SEC↗
BAKEWELL JOHN K	Director	A Award	2026-08-15	2026-08-18	215,517	—	$0	1,129,633	SEC↗
Schallenberger Mark A.	Chief Operating Officer	F Tax w/h	2026-02-15	2026-02-18	7,709	$0.58	$4.5K	663,157	SEC↗
Neils Scott C	CFO and Assistant Secretary	F Tax w/h	2026-01-15	2026-01-16	8,084	$0.65	$5.3K	843,381	SEC↗
Neils Scott C	CFO and Assistant Secretary	A Award deriv	2025-11-15	2025-11-18	526,582	—	$0	526,582	SEC↗
Schallenberger Mark A.	Chief Operating Officer	A Award deriv	2025-11-15	2025-11-18	584,506	—	$0	584,506	SEC↗
Browne Sean E	President and CEO	A Award deriv	2025-11-15	2025-11-18	789,874	—	$0	789,874	SEC↗
Neils Scott C	CFO and Assistant Secretary	A Award	2025-11-15	2025-11-18	263,291	—	$0	851,465	SEC↗
Schallenberger Mark A.	Chief Operating Officer	A Award	2025-11-15	2025-11-18	292,253	—	$0	670,866	SEC↗
Browne Sean E	President and CEO	A Award	2025-11-15	2025-11-18	394,937	—	$0	2,575,274	SEC↗
Lipschultz Tyler	Director	A Award	2025-11-15	2025-11-18	158,228	—	$0	158,228	SEC↗
JAIN ABHINAV	Director	A Award	2025-11-15	2025-11-18	158,228	—	$0	158,228	SEC↗
BAKEWELL JOHN K	Director	A Award	2025-11-15	2025-11-18	158,228	—	$0	158,228	SEC↗
Beeson Jonn R.	Director	A Award	2025-11-15	2025-11-18	158,228	—	$0	517,619	SEC↗
Vizirgianakis Stavros G.	Director	A Award	2025-11-15	2025-11-18	553,797	—	$0	7,515,570	SEC↗
BAKEWELL JOHN K	Director	A Award	2025-11-15	2025-11-18	158,228	—	$0	914,116	SEC↗
Neils Scott C	CFO	F Tax w/h	2025-08-15	2025-08-19	34,131	$0.63	$21.5K	588,174	SEC↗
Browne Sean E	President and CEO	F Tax w/h	2025-08-15	2025-08-19	10,605	$0.63	$6.7K	2,180,337	SEC↗
Orbimed ROF II LLC	10% Owner	S Sale	2025-04-10	2025-04-14	56,004,974	$0.42	$23.52M	0	SEC↗
Orbimed ROF II LLC	10% Owner	S Sale	2025-04-10	2025-04-14	17,109,618	$0.42	$7.19M	0	SEC↗
Neils Scott C	Chief Financial Officer	F Tax w/h	2025-01-15	2025-01-17	7,986	$0.53	$4.2K	622,305	SEC↗
Browne Sean E	President and CEO	F Tax w/h	2024-10-15	2024-10-16	105,442	$0.59	$62.2K	2,190,942	SEC↗
Browne Sean E	President and CEO	F Tax w/h	2024-08-15	2024-08-19	10,606	$0.60	$6.4K	2,296,384	SEC↗
Neils Scott C	Chief Financial Officer	F Tax w/h	2024-08-15	2024-08-19	34,132	$0.60	$20.5K	630,291	SEC↗
Brandt Kevin D	Chief Commercial Officer	F Tax w/h	2024-08-15	2024-08-19	56,333	$0.60	$33.8K	943,736	SEC↗
BAKEWELL JOHN K	Director	A Award	2024-08-15	2024-08-19	162,162	—	$0	755,888	SEC↗
Beeson Jonn R.	Director	A Award	2024-08-15	2024-08-19	162,162	—	$0	359,391	SEC↗
McNamara Robert	Director	A Award	2024-08-15	2024-08-19	162,162	—	$0	754,151	SEC↗
MITCHELL-KELLER LORI D	Director	A Award	2024-08-15	2024-08-19	162,162	—	$0	353,124	SEC↗
Vizirgianakis Stavros G.	Director	A Award	2024-08-15	2024-08-19	243,243	—	$0	6,456,368	SEC↗
Vizirgianakis Stavros G.	Director	A Award	2024-08-15	2024-08-19	505,405	—	$0	6,961,773	SEC↗
Schallenberger Mark A.	Chief Operations Officer	A Award	2024-04-03	2025-01-17	173,469	—	$0	378,613	SEC↗
Neils Scott C	Chief Financial Officer	A Award	2024-04-03	2024-04-05	177,551	—	$0	664,423	SEC↗
Schallenberger Mark A.	Chief Operations Officer	A Award	2024-04-03	2024-04-05	177,551	—	$0	382,695	SEC↗
Browne Sean E	President and CEO	A Award	2024-04-03	2024-04-05	731,632	—	$0	2,306,990	SEC↗
Brandt Kevin D	Chief Commercial Officer	A Award	2024-04-03	2024-04-05	184,209	—	$0	1,000,069	SEC↗
Neils Scott C	Chief Financial Officer	F Tax w/h	2024-01-16	2024-01-18	7,986	$1.09	$8.7K	486,872	SEC↗
Brandt Kevin D	Chief Commercial Officer	P Buy	2023-11-17	2023-11-17	41,670	$1.20	$50.0K	815,860	SEC↗
Browne Sean E	President and CEO	F Tax w/h	2023-10-15	2024-02-16	105,442	$1.08	$113.9K	1,575,358	SEC↗
Browne Sean E	President and CEO	F Tax w/h	2023-10-15	2023-10-17	111,721	$1.08	$120.7K	1,569,079	SEC↗
BAKEWELL JOHN K	Director	A Award deriv	2023-08-15	2023-08-17	28,230	—	$0	28,230	SEC↗
Beeson Jonn R.	Director	A Award deriv	2023-08-15	2023-08-17	28,230	—	$0	28,230	SEC↗
McNamara Robert	Director	A Award deriv	2023-08-15	2023-08-17	28,230	—	$0	28,230	SEC↗
MITCHELL-KELLER LORI D	Director	A Award deriv	2023-08-15	2023-08-17	28,230	—	$0	28,230	SEC↗
Vizirgianakis Stavros G.	Director	A Award deriv	2023-08-15	2023-08-17	42,345	—	$0	42,345	SEC↗
Brandt Kevin D	Chief Commercial Officer	A Award deriv	2023-08-15	2023-08-17	140,583	—	$0	140,583	SEC↗
Browne Sean E	President and CEO	A Award deriv	2023-08-15	2023-08-17	203,252	—	$0	203,252	SEC↗
Neils Scott C	Chief Financial Officer	A Award deriv	2023-08-15	2023-08-17	135,501	—	$0	135,501	SEC↗
Schallenberger Mark A.	Chief Operations Officer	A Award deriv	2023-08-15	2023-08-17	135,501	—	$0	135,501	SEC↗
BAKEWELL JOHN K	Director	A Award	2023-08-15	2023-08-17	145,180	—	$0	593,726	SEC↗
Beeson Jonn R.	Director	A Award	2023-08-15	2023-08-17	145,180	—	$0	197,229	SEC↗
McNamara Robert	Director	A Award	2023-08-15	2023-08-17	145,180	—	$0	591,989	SEC↗
MITCHELL-KELLER LORI D	Director	A Award	2023-08-15	2023-08-17	145,180	—	$0	190,962	SEC↗
Vizirgianakis Stavros G.	Director	A Award	2023-08-15	2023-08-17	217,770	—	$0	6,213,125	SEC↗
Brandt Kevin D	Chief Commercial Officer	F Tax w/h	2023-08-15	2023-08-17	49,880	$1.18	$58.9K	774,190	SEC↗
Brandt Kevin D	Chief Commercial Officer	A Award	2023-08-15	2023-08-17	120,499	—	$0	824,070	SEC↗
Browne Sean E	President and CEO	A Award	2023-08-15	2023-08-17	174,216	—	$0	1,680,800	SEC↗
Neils Scott C	Chief Financial Officer	F Tax w/h	2023-08-15	2023-08-17	25,246	$1.18	$29.8K	494,858	SEC↗
Neils Scott C	Chief Financial Officer	A Award	2023-08-15	2023-08-17	116,144	—	$0	520,104	SEC↗
Schallenberger Mark A.	Chief Operations Officer	A Award	2023-08-15	2023-08-17	116,144	—	$0	205,144	SEC↗
MITCHELL-KELLER LORI D	Director	A Award	2023-06-15	2023-06-15	45,782	—	$0	45,782	SEC↗
Beeson Jonn R.	Director	A Award	2023-05-15	2023-05-16	52,049	—	$0	52,049	SEC↗
Schallenberger Mark A.	Chief Operations Officer	A Award deriv	2023-02-15	2023-02-17	105,000	—	$0	105,000	SEC↗
Schallenberger Mark A.	Chief Operations Officer	A Award	2023-02-15	2023-02-17	89,000	—	$0	89,000	SEC↗
Neils Scott C	Chief Financial Officer	S Sale	2023-01-18	2023-01-19	8,673	$0.61	$5.3K	403,960	SEC↗
Vizirgianakis Stavros G.	Director	A Award	2022-11-15	2022-11-17	144,639	—	$0	5,995,355	SEC↗
Browne Sean E	President and CEO	S Sale	2022-10-19	2022-10-20	51,100	$0.62	$31.7K	1,506,584	SEC↗
Browne Sean E	President and CEO	S Sale	2022-10-18	2022-10-20	80,000	$0.68	$54.4K	1,557,684	SEC↗
Vizirgianakis Stavros G.	Director	P Buy deriv	2022-10-07	2022-10-11	566,214	—	$0	566,214	SEC↗
Vizirgianakis Stavros G.	Director	P Buy	2022-10-07	2022-10-11	2,264,861	$0.48	$1.09M	5,850,716	SEC↗
Vizirgianakis Stavros G.	Director	A Award	2022-08-25	2022-08-26	70,776	—	$0	3,585,855	SEC↗
Neils Scott C	Chief Financial Officer	S Sale	2022-08-17	2022-08-17	1,270	$0.48	$610	412,633	SEC↗
Brandt Kevin D	Chief Commercial Officer	S Sale	2022-08-17	2022-08-17	4,300	$0.48	$2.1K	703,571	SEC↗
Neils Scott C	Chief Financial Officer	S Sale	2022-08-16	2022-08-17	5,100	$0.48	$2.4K	413,903	SEC↗
Brandt Kevin D	Chief Commercial Officer	S Sale	2022-08-16	2022-08-17	18,700	$0.49	$9.2K	707,871	SEC↗
Rizzo Matthew	Director, 10% Owner	A Award	2022-08-15	2022-08-17	215,415	—	$0	215,415	SEC↗
Eggenberg Michael	Director, 10% Owner	A Award	2022-08-15	2022-08-17	215,415	—	$0	215,415	SEC↗
ORBIMED ADVISORS LLC	Director, 10% Owner	J Other	2022-08-15	2022-08-17	215,415	—	$0	215,415	SEC↗
ORBIMED ADVISORS LLC	Director, 10% Owner	J Other	2022-08-15	2022-08-17	215,415	—	$0	215,415	SEC↗
BAKEWELL JOHN K	Director	A Award	2022-08-15	2022-08-17	215,415	—	$0	448,546	SEC↗
McNamara Robert	Director	A Award	2022-08-15	2022-08-17	215,415	—	$0	446,809	SEC↗
Peters Jeffrey J	Director	A Award	2022-08-15	2022-08-17	215,415	—	$0	448,546	SEC↗
Neils Scott C	Chief Financial Officer	A Award	2022-08-15	2022-08-17	251,895	—	$0	419,003	SEC↗
Brandt Kevin D	Chief Commercial Officer	A Award	2022-08-15	2022-08-17	410,079	—	$0	726,571	SEC↗
Neils Scott C	Interim Chief Financial Offi	A Award deriv	2022-01-15	2022-01-18	109,164	—	$0	109,164	SEC↗
Neils Scott C	Interim Chief Financial Offi	A Award	2022-01-15	2022-01-18	88,983	—	$0	167,108	SEC↗
Browne Sean E	President and CEO	F Tax w/h	2021-10-15	2021-10-18	160,219	$1.11	$177.8K	1,637,684	SEC↗
JENSEN GREG	Vice President, Finance & CF	A Award deriv	2021-08-15	2021-08-17	192,308	—	$0	192,308	SEC↗
Brandt Kevin D	Chief Commercial Officer	A Award deriv	2021-08-15	2021-08-17	199,519	—	$0	199,519	SEC↗
JENSEN GREG	Vice President, Finance & CF	A Award	2021-08-15	2021-08-17	156,250	—	$0	285,331	SEC↗
Rizzo Matthew	Director	A Award	2021-08-15	2021-08-17	85,337	—	$0	120,549	SEC↗
Eggenberg Michael	Director	A Award	2021-08-15	2021-08-17	85,337	—	$0	120,549	SEC↗
McNamara Robert	Director	A Award	2021-08-15	2021-08-17	85,337	—	$0	231,394	SEC↗
Peters Jeffrey J	Director	A Award	2021-08-15	2021-08-17	85,337	—	$0	233,131	SEC↗
BAKEWELL JOHN K	Director	A Award	2021-08-15	2021-08-17	85,337	—	$0	233,131	SEC↗
Brandt Kevin D	Chief Commercial Officer	F Tax w/h	2021-08-15	2021-08-17	7,169	$1.20	$8.6K	316,492	SEC↗
Brandt Kevin D	Chief Commercial Officer	A Award	2021-08-15	2021-08-17	162,109	—	$0	323,661	SEC↗
Orbimed ROF II LLC	Director, 10% Owner	J Other	2021-08-15	2021-08-17	85,337	—	$0	120,549	SEC↗
Orbimed ROF II LLC	Director, 10% Owner	J Other	2021-08-15	2021-08-17	85,337	—	$0	120,549	SEC↗
Brandt Kevin D	Chief Commercial Officer	F Tax w/h	2021-07-09	2021-07-13	8,800	$1.74	$15.3K	161,552	SEC↗
Rizzo Matthew	Director, 10% Owner	X Exercise deriv	2020-11-17	2020-11-19	765,992	—	$0	0	SEC↗
Rizzo Matthew	Director, 10% Owner	X Exercise deriv	2020-11-17	2020-11-19	434,008	—	$0	0	SEC↗
Rizzo Matthew	Director, 10% Owner	X Exercise deriv	2020-11-17	2020-11-19	765,992	—	$0	0	SEC↗
Rizzo Matthew	Director, 10% Owner	X Exercise deriv	2020-11-17	2020-11-19	434,008	—	$0	0	SEC↗
Rizzo Matthew	Director, 10% Owner	X Exercise deriv	2020-11-17	2020-11-19	868,016	—	$0	0	SEC↗
Rizzo Matthew	Director, 10% Owner	X Exercise deriv	2020-11-17	2020-11-19	1,531,984	—	$0	0	SEC↗
Eggenberg Michael	Director, 10% Owner	X Exercise deriv	2020-11-17	2020-11-19	765,992	—	$0	0	SEC↗
Eggenberg Michael	Director, 10% Owner	X Exercise deriv	2020-11-17	2020-11-19	434,008	—	$0	0	SEC↗
Eggenberg Michael	Director, 10% Owner	X Exercise deriv	2020-11-17	2020-11-19	765,992	—	$0	0	SEC↗
Eggenberg Michael	Director, 10% Owner	X Exercise deriv	2020-11-17	2020-11-19	434,008	—	$0	0	SEC↗
Eggenberg Michael	Director, 10% Owner	X Exercise deriv	2020-11-17	2020-11-19	1,531,984	—	$0	0	SEC↗
Eggenberg Michael	Director, 10% Owner	X Exercise deriv	2020-11-17	2020-11-19	868,016	—	$0	0	SEC↗
ORBIMED ADVISORS LLC	Director, 10% Owner	X Exercise deriv	2020-11-17	2020-11-19	765,992	—	$0	0	SEC↗
ORBIMED ADVISORS LLC	Director, 10% Owner	X Exercise deriv	2020-11-17	2020-11-19	868,016	—	$0	0	SEC↗
ORBIMED ADVISORS LLC	Director, 10% Owner	X Exercise deriv	2020-11-17	2020-11-19	1,531,984	—	$0	0	SEC↗
ORBIMED ADVISORS LLC	Director, 10% Owner	X Exercise deriv	2020-11-17	2020-11-19	434,008	—	$0	0	SEC↗
ORBIMED ADVISORS LLC	Director, 10% Owner	X Exercise deriv	2020-11-17	2020-11-19	765,992	—	$0	0	SEC↗
ORBIMED ADVISORS LLC	Director, 10% Owner	X Exercise deriv	2020-11-17	2020-11-19	434,008	—	$0	0	SEC↗
Rizzo Matthew	Director, 10% Owner	X Exercise	2020-11-17	2020-11-19	1,531,984	$0.01	$15.3K	55,766,352	SEC↗
Rizzo Matthew	Director, 10% Owner	X Exercise	2020-11-17	2020-11-19	434,008	$0.01	$4.3K	16,168,704	SEC↗
Rizzo Matthew	Director, 10% Owner	X Exercise	2020-11-17	2020-11-19	434,008	$0.01	$4.3K	15,734,696	SEC↗
Rizzo Matthew	Director, 10% Owner	X Exercise	2020-11-17	2020-11-19	868,016	$0.01	$8.7K	17,036,720	SEC↗
Rizzo Matthew	Director, 10% Owner	X Exercise	2020-11-17	2020-11-19	765,992	$0.01	$7.7K	54,234,368	SEC↗
Rizzo Matthew	Director, 10% Owner	X Exercise	2020-11-17	2020-11-19	765,992	$0.01	$7.7K	53,468,376	SEC↗
Eggenberg Michael	Director, 10% Owner	X Exercise	2020-11-17	2020-11-19	434,008	$0.01	$4.3K	15,734,696	SEC↗
Eggenberg Michael	Director, 10% Owner	X Exercise	2020-11-17	2020-11-19	765,992	$0.01	$7.7K	53,468,376	SEC↗
Eggenberg Michael	Director, 10% Owner	X Exercise	2020-11-17	2020-11-19	765,992	$0.01	$7.7K	54,234,368	SEC↗
Eggenberg Michael	Director, 10% Owner	X Exercise	2020-11-17	2020-11-19	1,531,984	$0.01	$15.3K	55,766,352	SEC↗
Eggenberg Michael	Director, 10% Owner	X Exercise	2020-11-17	2020-11-19	434,008	$0.01	$4.3K	16,168,704	SEC↗
Eggenberg Michael	Director, 10% Owner	X Exercise	2020-11-17	2020-11-19	868,016	$0.01	$8.7K	17,036,720	SEC↗
ORBIMED ADVISORS LLC	Director, 10% Owner	X Exercise	2020-11-17	2020-11-19	1,531,984	$0.01	$15.3K	55,766,352	SEC↗
ORBIMED ADVISORS LLC	Director, 10% Owner	X Exercise	2020-11-17	2020-11-19	434,008	$0.01	$4.3K	16,168,704	SEC↗
ORBIMED ADVISORS LLC	Director, 10% Owner	X Exercise	2020-11-17	2020-11-19	434,008	$0.01	$4.3K	15,734,696	SEC↗
ORBIMED ADVISORS LLC	Director, 10% Owner	X Exercise	2020-11-17	2020-11-19	868,016	$0.01	$8.7K	17,036,720	SEC↗
ORBIMED ADVISORS LLC	Director, 10% Owner	X Exercise	2020-11-17	2020-11-19	765,992	$0.01	$7.7K	54,234,368	SEC↗
ORBIMED ADVISORS LLC	Director, 10% Owner	X Exercise	2020-11-17	2020-11-19	765,992	$0.01	$7.7K	53,468,376	SEC↗
Browne Sean E	President and Chief Executiv	A Award deriv	2020-11-15	2020-11-16	1,468,859	—	$0	1,468,859	SEC↗
Browne Sean E	President and Chief Executiv	A Award	2020-11-15	2020-11-16	1,468,859	—	$0	1,797,903	SEC↗
Orbimed ROF II LLC	Director, 10% Owner	A Award	2020-10-01	2020-10-05	11,969,619	$1.07	$12.81M	15,300,688	SEC↗
Orbimed ROF II LLC	Director, 10% Owner	A Award	2020-10-01	2020-10-05	46,784,775	$1.07	$50.06M	52,702,384	SEC↗
Rizzo Matthew	Director, 10% Owner	A Award	2020-10-01	2020-10-05	46,784,775	$1.07	$50.06M	52,702,384	SEC↗
Rizzo Matthew	Director, 10% Owner	A Award	2020-10-01	2020-10-05	11,969,619	$1.07	$12.81M	15,300,688	SEC↗
Eggenberg Michael	Director, 10% Owner	A Award	2020-10-01	2020-10-05	11,969,619	$1.07	$12.81M	15,300,688	SEC↗
Eggenberg Michael	Director, 10% Owner	A Award	2020-10-01	2020-10-05	46,784,775	$1.07	$50.06M	52,702,384	SEC↗
Brandt Kevin D	Chief Commercial Officer	A Award deriv	2020-08-15	2020-08-18	119,942	—	$0	119,942	SEC↗
JENSEN GREG	VP, Finance and CFO	A Award deriv	2020-08-15	2020-08-18	119,942	—	$0	119,942	SEC↗
Brandt Kevin D	Chief Commercial Officer	A Award	2020-08-15	2020-08-18	95,183	—	$0	170,352	SEC↗
JENSEN GREG	VP, Finance and CFO	A Award	2020-08-15	2020-08-18	95,183	—	$0	129,081	SEC↗
Eggenberg Michael	Director, 10% Owner	A Award deriv	2020-05-06	2020-05-20	868,016	—	$0	868,016	SEC↗
Eggenberg Michael	Director, 10% Owner	A Award deriv	2020-05-06	2020-05-20	1,531,984	—	$0	1,531,984	SEC↗
Rizzo Matthew	Director, 10% Owner	A Award deriv	2020-05-06	2020-05-20	868,016	—	$0	868,016	SEC↗
Rizzo Matthew	Director, 10% Owner	A Award deriv	2020-05-06	2020-05-20	1,531,984	—	$0	1,531,984	SEC↗
Orbimed ROF II LLC	Director, 10% Owner	A Award deriv	2020-05-06	2020-05-20	868,016	—	$0	868,016	SEC↗
Orbimed ROF II LLC	Director, 10% Owner	A Award deriv	2020-05-06	2020-05-20	1,531,984	—	$0	1,531,984	SEC↗
BAKEWELL JOHN K	Director	A Award	2020-02-05	2020-02-07	116,197	—	$0	147,794	SEC↗
McNamara Robert	Director	A Award	2020-02-05	2020-02-07	116,197	—	$0	146,057	SEC↗
Peters Jeffrey J	Director	A Award	2020-02-05	2020-02-07	116,197	—	$0	147,794	SEC↗
Rizzo Matthew	Director, 10% Owner	A Award	2020-02-05	2020-02-07	70,423	—	$0	91,256	SEC↗
Eggenberg Michael	Director, 10% Owner	A Award	2020-02-05	2020-02-07	70,423	—	$0	91,256	SEC↗
Orbimed ROF II LLC	Director, 10% Owner	J Other	2020-02-05	2020-02-07	70,423	—	$0	91,256	SEC↗
Orbimed ROF II LLC	Director, 10% Owner	J Other	2020-02-05	2020-02-07	70,423	—	$0	91,256	SEC↗
Eggenberg Michael	Director, 10% Owner	A Award	2019-10-30	2019-10-31	20,833	—	$0	20,833	SEC↗
Orbimed ROF II LLC	Director, 10% Owner	J Other	2019-10-30	2019-10-31	20,833	—	$0	20,833	SEC↗
Orbimed ROF II LLC	Director, 10% Owner	J Other	2019-10-30	2019-10-31	20,833	—	$0	20,833	SEC↗
Rizzo Matthew	Director, 10% Owner	A Award	2019-10-30	2019-10-31	20,833	—	$0	20,833	SEC↗
Browne Sean E	President and CEO	A Award deriv	2019-10-15	2019-10-15	329,044	—	$0	329,044	SEC↗
Browne Sean E	President and CEO	A Award	2019-10-15	2019-10-15	329,044	—	$0	329,044	SEC↗
Peters Jeffrey J	Director	A Award	2019-09-24	2019-09-25	5,555	—	$0	31,597	SEC↗
BAKEWELL JOHN K	Director	A Award	2019-09-24	2019-09-25	5,555	—	$0	31,597	SEC↗
McNamara Robert	Director	A Award	2019-09-24	2019-09-25	9,027	—	$0	29,860	SEC↗
JENSEN GREG	VP, Finance & CFO	A Award deriv	2019-08-15	2019-08-16	39,063	—	$0	39,063	SEC↗
Brandt Kevin D	Chief Commercial Officer	A Award deriv	2019-08-15	2019-08-16	40,527	—	$0	40,527	SEC↗
JENSEN GREG	VP, Finance & CFO	A Award	2019-08-15	2019-08-16	33,898	—	$0	33,898	SEC↗
Brandt Kevin D	Chief Commercial Officer	A Award	2019-08-15	2019-08-16	35,169	—	$0	75,169	SEC↗
Orbimed ROF II LLC	Director, 10% Owner	A Award deriv	2019-04-01	2019-04-03	434,008	—	$0	434,008	SEC↗
Orbimed ROF II LLC	Director, 10% Owner	A Award deriv	2019-04-01	2019-04-03	765,992	—	$0	765,992	SEC↗
Eggenberg Michael	Director, 10% Owner	A Award deriv	2019-04-01	2019-04-03	434,008	—	$0	434,008	SEC↗
Eggenberg Michael	Director, 10% Owner	A Award deriv	2019-04-01	2019-04-03	765,992	—	$0	765,992	SEC↗
Rizzo Matthew	Director, 10% Owner	A Award deriv	2019-04-01	2019-04-03	434,008	—	$0	434,008	SEC↗
Rizzo Matthew	Director, 10% Owner	A Award deriv	2019-04-01	2019-04-03	765,992	—	$0	765,992	SEC↗
Berlin Ronald G.	VP & Chief Operations Office	A Award deriv	2019-01-15	2019-01-16	100,000	—	$0	100,000	SEC↗
Mainelli Michael	Interim CEO	A Award deriv	2018-10-15	2018-10-15	240,000	—	$0	240,000	SEC↗
ORBIMED ADVISORS LLC	Director, 10% Owner	A Award deriv	2018-09-17	2018-09-19	765,992	—	$0	765,992	SEC↗
ORBIMED ADVISORS LLC	Director, 10% Owner	A Award deriv	2018-09-17	2018-09-19	434,008	—	$0	434,008	SEC↗
Eggenberg Michael	Director, 10% Owner	A Award deriv	2018-09-17	2018-09-19	765,992	—	$0	765,992	SEC↗
Eggenberg Michael	Director, 10% Owner	A Award deriv	2018-09-17	2018-09-19	434,008	—	$0	434,008	SEC↗
Rizzo Matthew	Director, 10% Owner	A Award deriv	2018-09-17	2018-09-19	434,008	—	$0	434,008	SEC↗
Rizzo Matthew	Director, 10% Owner	A Award deriv	2018-09-17	2018-09-19	765,992	—	$0	765,992	SEC↗
Lenzen Kathie J.	Chief Financial Officer	A Award deriv	2018-09-15	2018-09-18	130,000	—	$0	130,000	SEC↗
Brandt Kevin D	VP & Chief Commercial Office	A Award deriv	2018-08-15	2018-08-16	30,770	—	$0	30,770	SEC↗
O'Connell Carl	Chief Executive Officer	A Award deriv	2018-08-15	2018-08-16	200,000	—	$0	200,000	SEC↗
Brandt Kevin D	VP & Chief Commercial Office	A Award	2018-08-15	2018-08-16	40,000	—	$0	40,000	SEC↗
Peters Jeffrey J	Director	A Award	2018-08-15	2018-08-16	26,042	—	$0	26,042	SEC↗
McNamara Robert	Director	A Award	2018-05-02	2018-05-04	20,833	—	$0	20,833	SEC↗
BAKEWELL JOHN K	Director	A Award	2018-04-09	2018-04-10	26,042	—	$0	26,042	SEC↗
Mainelli Michael	Director	A Award	2018-04-08	2018-04-10	20,833	—	$0	20,833	SEC↗
ORBIMED ADVISORS LLC	Director, 10% Owner	D To issuer deriv	2018-02-14	2018-02-23	18,810,000	$46.56	$875.79M	0	SEC↗
ORBIMED ADVISORS LLC	Director, 10% Owner	D To issuer deriv	2018-02-14	2018-02-23	1,428,553	$34.80	$49.71M	0	SEC↗
ORBIMED ADVISORS LLC	Director, 10% Owner	D To issuer deriv	2018-02-14	2018-02-23	809,614	$34.80	$28.17M	0	SEC↗
ORBIMED ADVISORS LLC	Director, 10% Owner	D To issuer deriv	2018-02-14	2018-02-23	33,190,000	$46.56	$1.55B	0	SEC↗
Eggenberg Michael	Director, 10% Owner	D To issuer deriv	2018-02-14	2018-02-26	0	$46.56	$0	0	SEC↗
Eggenberg Michael	Director, 10% Owner	D To issuer deriv	2018-02-14	2018-02-26	0	$34.80	$0	0	SEC↗
Eggenberg Michael	Director, 10% Owner	D To issuer deriv	2018-02-14	2018-02-26	0	$34.80	$0	0	SEC↗
Eggenberg Michael	Director, 10% Owner	D To issuer deriv	2018-02-14	2018-02-26	0	$46.56	$0	0	SEC↗
Rizzo Matthew	Director, 10% Owner	D To issuer deriv	2018-02-14	2018-02-26	0	$46.56	$0	0	SEC↗
Rizzo Matthew	Director, 10% Owner	D To issuer deriv	2018-02-14	2018-02-26	0	$46.56	$0	0	SEC↗
Rizzo Matthew	Director, 10% Owner	D To issuer deriv	2018-02-14	2018-02-26	0	$34.80	$0	0	SEC↗
Rizzo Matthew	Director, 10% Owner	D To issuer deriv	2018-02-14	2018-02-26	0	$34.80	$0	0	SEC↗
ORBIMED ADVISORS LLC	Director, 10% Owner	P Buy	2018-02-14	2018-02-23	342,132	$7.20	$2.46M	3,316,128	SEC↗
ORBIMED ADVISORS LLC	Director, 10% Owner	P Buy	2018-02-14	2018-02-23	603,687	$7.20	$4.35M	5,890,884	SEC↗
ORBIMED ADVISORS LLC	Director, 10% Owner	A Award	2018-02-14	2018-02-23	2,905,396	$7.20	$20.92M	2,973,996	SEC↗
ORBIMED ADVISORS LLC	Director, 10% Owner	A Award	2018-02-14	2018-02-23	5,126,534	$7.20	$36.91M	5,287,197	SEC↗
Eggenberg Michael	Director, 10% Owner	A Award	2018-02-14	2018-02-26	2,905,396	$7.20	$20.92M	2,973,996	SEC↗
Eggenberg Michael	Director, 10% Owner	P Buy	2018-02-14	2018-02-26	603,687	$7.20	$4.35M	5,890,884	SEC↗
Eggenberg Michael	Director, 10% Owner	P Buy	2018-02-14	2018-02-26	342,132	$7.20	$2.46M	3,316,128	SEC↗
Eggenberg Michael	Director, 10% Owner	A Award	2018-02-14	2018-02-26	5,126,534	$7.20	$36.91M	5,287,197	SEC↗
Rizzo Matthew	Director, 10% Owner	P Buy	2018-02-14	2018-02-26	342,132	$7.20	$2.46M	3,316,128	SEC↗
Rizzo Matthew	Director, 10% Owner	P Buy	2018-02-14	2018-02-26	603,687	$7.20	$4.35M	5,890,884	SEC↗
Rizzo Matthew	Director, 10% Owner	A Award	2018-02-14	2018-02-26	2,905,396	$7.20	$20.92M	2,973,996	SEC↗
Rizzo Matthew	Director, 10% Owner	A Award	2018-02-14	2018-02-26	5,126,534	$7.20	$36.91M	5,287,197	SEC↗
TIMKO ERIC BERNARD	Director	A Award	2017-07-25	2017-07-27	51,948	—	$0	51,948	SEC↗
BUCKMAN PAUL	Director	A Award	2017-07-25	2017-07-27	51,948	—	$0	72,049	SEC↗
LOPACH MICHAEL A	Director	A Award	2017-07-25	2017-07-27	51,948	—	$0	95,335	SEC↗
Swanson Kent L	Director	A Award	2017-07-25	2017-07-27	51,948	—	$0	318,641	SEC↗
Mazzocchi Rudy A	Director	A Award	2017-07-25	2017-07-27	51,948	—	$0	51,948	SEC↗
DEEDRICK JOHN ARTHUR	Director	A Award	2017-07-25	2017-07-27	51,948	—	$0	100,434	SEC↗
Swanson Kent L	Director	X Exercise deriv	2016-11-17	2016-11-23	150,000	—	$0	150,000	SEC↗
Goldberger Daniel S	Chief Executive Officer	X Exercise deriv	2016-11-17	2016-11-25	120,000	—	$0	120,000	SEC↗
Swanson Kent L	Director	X Exercise	2016-11-17	2016-11-23	150,000	$0.75	$112.5K	266,693	SEC↗
Goldberger Daniel S	Chief Executive Officer	X Exercise	2016-11-17	2016-11-25	120,000	$0.75	$90.0K	135,510	SEC↗
Swanson Kent L	Director	X Exercise deriv	2016-11-14	2016-11-23	150,000	—	$0	0	SEC↗
Goldberger Daniel S	Chief Executive Officer	X Exercise deriv	2016-11-14	2016-11-25	120,000	—	$0	0	SEC↗
O'Connell Carl	President	A Award deriv	2016-10-06	2016-10-11	300,000	—	$0	300,000	SEC↗
TIMKO ERIC BERNARD	Director	A Award deriv	2016-07-05	2016-07-06	29,700	—	$0	29,700	SEC↗
Mazzocchi Rudy A	Director	A Award deriv	2016-07-05	2016-07-06	29,700	—	$0	29,700	SEC↗
LOPACH MICHAEL A	Director	A Award	2016-07-05	2016-07-06	20,101	—	$0	43,387	SEC↗
Swanson Kent L	Director	A Award	2016-07-05	2016-07-06	20,101	—	$0	116,693	SEC↗
BUCKMAN PAUL	Director	A Award	2016-07-05	2016-07-06	20,101	—	$0	20,101	SEC↗
DEEDRICK JOHN ARTHUR	Director	A Award	2016-07-05	2016-07-06	20,101	—	$0	48,486	SEC↗
Kirschman David Louis	Director, 10% Owner	D To issuer deriv	2016-07-02	2016-07-06	40,000	—	$0	0	SEC↗
LOPACH MICHAEL A	Director	M Exercise deriv	2016-07-01	2016-07-06	11,764	—	$0	0	SEC↗
Swanson Kent L	Director	M Exercise deriv	2016-07-01	2016-07-06	11,764	—	$0	0	SEC↗
WICKWIRE JON M.	Other	M Exercise deriv	2016-07-01	2016-07-06	11,764	—	$0	0	SEC↗
DEEDRICK JOHN ARTHUR	Director	M Exercise deriv	2016-07-01	2016-07-06	11,764	—	$0	0	SEC↗
Goodman David	Other	M Exercise deriv	2016-07-01	2016-07-06	11,764	—	$0	0	SEC↗
LOPACH MICHAEL A	Director	M Exercise	2016-07-01	2016-07-06	11,764	—	$0	23,286	SEC↗
Swanson Kent L	Director	M Exercise	2016-07-01	2016-07-06	11,764	—	$0	96,592	SEC↗
WICKWIRE JON M.	Other	M Exercise	2016-07-01	2016-07-06	11,764	—	$0	43,011	SEC↗
DEEDRICK JOHN ARTHUR	Director	M Exercise	2016-07-01	2016-07-06	11,764	—	$0	28,385	SEC↗
Goodman David	Other	M Exercise	2016-07-01	2016-07-06	11,764	—	$0	11,764	SEC↗
Goldberger Daniel S	Chief Executive Officer	P Buy	2016-05-09	2016-05-10	5,000	$2.34	$11.7K	86,522	SEC↗
Swanson Kent L	Director	L Small acq	2015-12-18	2015-12-21	1,000	$2.80	$2.8K	84,828	SEC↗
Swanson Kent L	Director	L Small acq	2015-12-14	2015-12-21	552	$3.19	$1.8K	83,828	SEC↗
Swanson Kent L	Director	L Small acq	2015-12-04	2015-12-21	148	$2.81	$416	83,276	SEC↗
Swanson Kent L	Director	P Buy	2015-12-03	2015-12-03	1,000	$2.83	$2.8K	83,128	SEC↗
Swanson Kent L	Director	P Buy	2015-12-03	2015-12-03	300	$2.81	$843	81,128	SEC↗
Swanson Kent L	Director	P Buy	2015-12-03	2015-12-03	1,000	$2.82	$2.8K	82,128	SEC↗
Swanson Kent L	Director	P Buy	2015-12-01	2015-12-03	1,000	$2.85	$2.9K	80,828	SEC↗
Swanson Kent L	Director	P Buy	2015-11-20	2015-11-20	4,976	$3.00	$14.9K	79,828	SEC↗
Kirschman David Louis	EVP & Chief Scientific Offic	P Buy	2015-11-20	2015-11-23	1,000	$2.94	$2.9K	1,700,063	SEC↗
Kirschman David Louis	EVP & Chief Scientific Offic	P Buy	2015-11-20	2015-11-23	1,000	$3.04	$3.0K	1,701,063	SEC↗
Kirschman David Louis	EVP & Chief Scientific Offic	P Buy	2015-11-19	2015-11-19	1,000	$2.94	$2.9K	1,699,063	SEC↗
Swanson Kent L	Director	P Buy	2015-11-19	2015-11-20	24	$2.90	$70	74,852	SEC↗
Kirschman David Louis	EVP & Chief Scientific Offic	P Buy	2015-11-18	2015-11-19	1,000	$2.86	$2.9K	1,698,063	SEC↗
Goldberger Daniel S	Chief Executive Officer	P Buy	2015-11-16	2015-11-16	3,000	$2.80	$8.4K	15,510	SEC↗